Gene Symbol: ITIH4
Description: inter-alpha-trypsin inhibitor heavy chain family member 4
Alias: GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120, inter-alpha-trypsin inhibitor heavy chain H4, ITI heavy chain H4, inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein), inter-alpha-inhibitor heavy chain 4, inter-alpha-trypsin inhibitor family heavy chain-related protein, inter-alpha-trypsin inhibitor, heavy chain-like, 1, plasma kallikrein-sensitive glycoprotein 120
Species: human
Products:     ITIH4

Top Publications

  1. Tobe T, Saguchi K, Hashimoto K, Miura N, Tomita M, Li F, et al. Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21-->p14. Cytogenet Cell Genet. 1995;71:296-8 pubmed
    ..We report the mapping of this gene (ITIHL1) by fluorescence in situ hybridization using a 2.5-kb cDNA fragment as a probe...
  2. Choi Miura N, Sano Y, Oda E, Nakano Y, Tobe T, Yanagishita T, et al. Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. J Biochem. 1995;117:400-7 pubmed
    ..Western-blot analysis of human plasma revealed that only a 120 kDa protein, GP120, reacted with anti-GP57 antibody...
  3. Saguchi K, Tobe T, Hashimoto K, Nagasaki Y, Oda E, Nakano Y, et al. Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1). J Biochem. 1996;119:898-905 pubmed
    ..clones that encode the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1) were isolated and characterized...
  4. Saguchi K, Tobe T, Hashimoto K, Sano Y, Nakano Y, Miura N, et al. Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein. J Biochem. 1995;117:14-8 pubmed
    The cDNA encoding inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) was cloned from human liver cDNA libraries...
  5. Clarke C, Yip C, Badgwell D, Fung E, Coombes K, Zhang Z, et al. Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer. Gynecol Oncol. 2011;122:548-53 pubmed publisher
    ..2M), Connective Tissue Activating Protein III (CTAPIII), and Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)]...
  6. Ivancic M, Anson L, Pickhardt P, Megna B, Pooler B, Clipson L, et al. Conserved serum protein biomarkers associated with growing early colorectal adenomas. Proc Natl Acad Sci U S A. 2019;116:8471-8480 pubmed publisher
    ..The markers F5, ITIH4, LRG1, and VTN were each elevated both in this patient study and in the studies of the Pirc rat model...
  7. Gourgari E, Ma J, Playford M, Mehta N, Goldman R, Remaley A, et al. Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case-control study. Cardiovasc Diabetol. 2019;18:43 pubmed publisher
    ..In a subgroup of poorly controlled T1DM patients, inter alpha trypsin inhibitor 4 (ITIH4) was dramatically elevated (P < 0...
  8. Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang J, et al. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014;23:5492-504 pubmed publisher
    ..29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes...
  9. McElrath T, Cantonwine D, Jeyabalan A, Doss R, Page G, Roberts J, et al. Circulating microparticle proteins obtained in the late first trimester predict spontaneous preterm birth at less than 35 weeks' gestation: a panel validation with specific characterization by parity. Am J Obstet Gynecol. 2019;: pubmed publisher
    ..74 (95% CI, 0.63-0.81). A separate panel of markers (IC1, LCAT, TRFE, and ITIH4), which stratified risk among mothers with a parity of 0, showed an AUC of 0.77 (95% CI, 0.61-0.90)...

More Information


  1. Vasmatzis G, Kosari F, Murphy S, Terra S, Kovtun I, Harris F, et al. Large Chromosomal Rearrangements Yield Biomarkers to Distinguish Low-Risk From Intermediate- and High-Risk Prostate Cancer. Mayo Clin Proc. 2019;94:27-36 pubmed publisher
    ..rearrangements (CRs) can distinguish low risk of progression (LRP) from intermediate and high risk of progression (IHRP) to prostate cancer (PCa) and if these CRs have the potential to identify men with LRP on needle biopsy that harbor ..
  2. Soler L, Dabrowski R, Garcia N, Alava M, Lampreave F, Piñeiro M, et al. Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species. J Dairy Sci. 2019;102:539-546 pubmed publisher
    The aim of the study was to investigate the concentrations of acute-phase inter-α-trypsin inhibitor heavy chain 4 (ITIH4) in serum and milk of cows with subclinical mastitis caused by Streptococcus spp...
  3. Lee E, Yang S, Kim K, Cha H, Lee S, Kim J, et al. Inter-alpha Inhibitor H4 as a Potential Biomarker Predicting the Treatment Outcomes in Patients with Hepatocellular Carcinoma. Cancer Res Treat. 2018;50:646-657 pubmed publisher
    ..Levels of inter-alpha inhibitor H4 (ITIH4), fibrinogen gamma chain, keratin 9/1 complex, carbonic anhydrase I, and carbonmonoxyhemoglobin S were changed by ..
  4. Cai L, Huang T, Su J, Zhang X, Chen W, Zhang F, et al. Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia. Mol Ther Nucleic Acids. 2018;12:433-442 pubmed publisher
    ..procedures, we have found that (1) the cerebellum may play a crucial role in the pathogenesis of SCZ and (2) ITIH4 may be utilized as a clinical biomarker for the diagnosis of SCZ...
  5. Kawaguchi H, Matsumoto I, Osada A, Kurata I, Ebe H, Tanaka Y, et al. Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis. Arthritis Res Ther. 2018;20:66 pubmed publisher
    ..the relationship between the expression of the identified protein (inter-alpha-trypsin inhibitor heavy chain 4 [ITIH4]) and clinical features was evaluated, and the levels of citrullinated ITIH4 were compared before and after ..
  6. Ivancic M, Irving A, Jonakin K, Dove W, Sussman M. The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. Cancer Prev Res (Phila). 2014;7:1160-9 pubmed publisher
    ..Tumor multiplicity correlated with protein expression changes, and most tumors grew during the study. EGFR, LRG1, ITIH4, and F5 displayed the most robust tumor-associated protein expression changes over time...
  7. Liu H, Alyass A, Abadi A, Peralta Romero J, Suarez F, Gómez Zamudio J, et al. Fine-mapping of 98 obesity loci in Mexican children. Int J Obes (Lond). 2019;43:23-32 pubmed publisher
    ..or recessive (N = 1) models, and a significant interaction was found between rs274609 (TNNI3K) and rs1010553 (ITIH4) on childhood obesity risk...
  8. Tess B, Aith F. Intersectorial health-related policies: the use of a legal and theoretical framework to propose a typology to a case study in a Brazilian municipality. Cien Saude Colet. 2014;19:4449-56 pubmed
    This article analyzes intersectorial health-related policies (IHRP) based on a case study performed in 2008-2009 that mapped the social policies of the city of Piracicaba, State of Sao Paulo, Brazil...
  9. Subbannayya Y, Mir S, Renuse S, Manda S, Pinto S, Puttamallesh V, et al. Identification of differentially expressed serum proteins in gastric adenocarcinoma. J Proteomics. 2015;127:80-8 pubmed publisher
    ..Proteins that showed increased expression in gastric cancer included inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), Mannose-binding protein C (MBL2), sex hormone-binding globulin (SHBG), insulin-like growth factor-binding ..
  10. Miyake Y, Tanaka K, Arakawa M. ITIH3 and ITIH4 polymorphisms and depressive symptoms during pregnancy in Japan: the Kyushu Okinawa Maternal and Child Health Study. J Neural Transm (Vienna). 2018;125:1503-1509 pubmed publisher
    ITIH3 and ITIH4 are involved in the stabilization of the extracellular matrix...
  11. Huang J, Luo G, Zhang Z, Wang X, Ju Z, Qi C, et al. iTRAQ-proteomics and bioinformatics analyses of mammary tissue from cows with clinical mastitis due to natural infection with Staphylococci aureus. BMC Genomics. 2014;15:839 pubmed publisher
    ..Up-regulation of collagen, type I, alpha 1 (COL1A1) and inter-alpha (Globulin) inhibitor H4 (ITIH4) in the mastitis-infected tissue was confirmed by Western blotting and Immunohistochemistry...
  12. Wang Q, Su X, Jiang X, Dong X, Fan Y, Zhang J, et al. iTRAQ technology-based identification of human peripheral serum proteins associated with depression. Neuroscience. 2016;330:291-325 pubmed publisher
    ..Proteomic studies revealed that levels of c-reaction protein (CRP), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), serum amyloid A1 (SAA1) and angiopoietin-like 3 (ANGPTL3) were substantially increased in depressed patients ..
  13. Voisin S, Almén M, Zheleznyakova G, Lundberg L, Zarei S, Castillo S, et al. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers. Genome Med. 2015;7:103 pubmed publisher
  14. Kormosh N, Davidova T, Kopyltsov V, Serebryakova M, Kabieva A, Voyushin K, et al. Conformational changes in inter-?-trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma. Mol Med Rep. 2015;12:4483-4493 pubmed publisher showed conformational changes of two serum albumin proteins and inter???trypsin inhibitor heavy chain 4 (ITIH4) in mice with B16 melanoma compared to tumor?free mice, as determined by differences in the products of ..
  15. Liu C, Lin J. Integral Histogram with Random Projection for Pedestrian Detection. PLoS ONE. 2015;10:e0142820 pubmed publisher
    ..Finally, the two ideas are combined into a new descriptor termed IHRP, which outperforms the HOG feature with less dimensions and higher speed.
  16. Lu Y, Chen X, Yin Z, Zhu S, Wu D, Chen X. Screening for potential serum biomarkers in rat mesangial proliferative nephritis. Proteomics. 2016;16:1015-22 pubmed publisher
    ..Moreover, we applied LC-MS to detect differential protein expression and found A2M, C3, ITIH4, ITIH3, VDBP, AFM, and SERPINF2 to be upregulated, and ES1, HPX, SERPINC1, SERPINA1F, SERPINA4, SERPINA3K, SPI, TF,..
  17. Cubedo J, Padró T, Formiga F, Ferrer A, Padrós G, Peña E, et al. Inflammation and hemostasis in older octogenarians: implication in 5-year survival. Transl Res. 2017;185:34-46.e9 pubmed publisher
    ..UHOs showed a coordinated change in several inflammation-related proteins (AMBP, RBP4, and ITIH4; P < 0...
  18. Davalieva K, Kiprijanovska S, Maleva Kostovska I, Stavridis S, Stankov O, Komina S, et al. Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer. Proteomes. 2017;6: pubmed publisher
    ..Twenty proteins (CD14, AHSG, ENO1, ANXA1, CLU, COL6A1, C3, FGA, FGG, HPX, PTGDS, S100A9, LMAN2, ITIH4, ACTA2, GRN, HBB, PEBP1, CTSB, SPP1) are oncogenes, tumor suppressors, and multifunctional proteins with highly ..
  19. Ju Z, Jiang Q, Liu G, Wang X, Luo G, Zhang Y, et al. Solexa sequencing and custom microRNA chip reveal repertoire of microRNAs in mammary gland of bovine suffering from natural infectious mastitis. Anim Genet. 2018;49:3-18 pubmed publisher
    ..Several interaction networks and regulators involved in mastitis susceptibility, such as ALCAM, COL1A1, APOP4, ITIH4, CRP and fibrinogen alpha (FGA), were highlighted...
  20. López Úbeda R, García Vázquez F, Romar R, Gadea J, Muñoz M, Hunter R, et al. Oviductal Transcriptome Is Modified after Insemination during Spontaneous Ovulation in the Sow. PLoS ONE. 2015;10:e0130128 pubmed publisher
    ..and animals, where they were over-expressed in the presence of spermatozoa or pre-implantation embryos (C3, IGHG1, ITIH4, TNF and SERPINE1) whereas others were not previously reported (SAA2, ALOX12, CD1D and SPP1)...
  21. Soler L, Garcia N, Unzueta A, Pineiro M, Alava M, Lampreave F. Purification and determination of C-reactive protein and inter-?-trypsin inhibitor heavy chain 4 in dogs after major surgery through generation of specific antibodies. Vet Immunol Immunopathol. 2016;179:26-31 pubmed publisher
    Inter-?-trypsin inhibitor heavy chain 4 (ITIH4) and C-reactive protein (CRP) have been isolated from acute phase dog sera by affinity chromatography with insolubilized polyclonal antibodies anti pig Major Acute phase Protein (Pig-MAP) ..
  22. Jean L, Smih F, Olivier E, Soury E, Simon Chazottes D, Guenet J, et al. Comparative assignments of the genes of the inter-alpha-inhibitor family in human and mouse: ITIH4 is close to ITIH1 and ITIH3, on HSA 3 and MMU 14. Genomics. 1997;41:139-40 pubmed
  23. Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu P, Yamashita T, et al. cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein. FEBS Lett. 1995;357:207-11 pubmed
    ..Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-alpha-trypsin inhibitor (ITI) superfamily. ..
  24. Wang Q, Li D, Zhang W, Tang B, Li Q, Li L. Evaluation of proteomics-identified CCL18 and CXCL1 as circulating tumor markers for differential diagnosis between ovarian carcinomas and benign pelvic masses. Int J Biol Markers. 2011;26:262-73 pubmed publisher
    ..Six differentially expressed proteins (APP, CA 125, CCL18, CXCL1, IL-8, and ITIH4) were separated by high-performance liquid chromatography and identified by matrix-assisted laser desorption/..
  25. Finseth P, Sønderby I, Djurovic S, Agartz I, Malt U, Melle I, et al. Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia. J Affect Disord. 2014;163:110-4 pubmed publisher
    ..This may be useful in understanding molecular mechanisms of suicidal behaviour in severe mental disorders, although replication is warranted. ..
  26. Ohi K, Shimada T, Nitta Y, Kihara H, Okubo H, Uehara T, et al. Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex. Psychiatr Genet. 2016;26:142-3 pubmed publisher
  27. Pineiro M, Alava M, González Ramón N, Osada J, Lasierra P, Larrad L, et al. ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun. 1999;263:224-9 pubmed
    The serum concentration of the inter-alpha trypsin inhibitor heavy chain 4 protein (ITIH4) increases (from 1...
  28. Chandler K, Brnáková Z, Sanda M, Wang S, Stalnaker S, Bridger R, et al. Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4. J Proteome Res. 2014;13:3314-29 pubmed publisher
    Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is a 120 kDa acute-phase glycoprotein produced primarily in the liver, secreted into the blood, and identified in serum...
  29. Jayapalan J, Ng K, Shuib A, Razack A, Hashim O. Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and saposin B but increased expression of an inter-alpha-trypsin inhibitor heavy chain 4 fragment. Electrophoresis. 2013;34:1663-9 pubmed publisher
  30. Smeland O, Wang Y, Frei O, Li W, Hibar D, Franke B, et al. Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms. Schizophr Bull. 2017;: pubmed publisher
    ..05, we identified 2 loci shared between SCZ and ICV implicating genes FOXO3 (rs10457180) and ITIH4 (rs4687658), 2 loci shared between SCZ and hippocampal volume implicating SLC4A10 (rs4664442) and SPATS2L (..
  31. Kroczynska B, King Simmons L, Alloza L, Alava M, Elguindi E, Blond S. BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. Biochem Biophys Res Commun. 2005;338:1467-77 pubmed
    ..279 (2004) 11432-11443]. Here, we identified a new variant of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) that also interacts with the SANT2 domain of HTJ1...
  32. Tan Z, Hu Z, Cai E, Alev C, Yang T, Li Z, et al. Serological targeted analysis of an ITIH4 peptide isoform: a preterm birth biomarker and its associated SNP implications. J Genet Genomics. 2015;42:507-10 pubmed publisher
  33. Almalik A, Benabdelkamel H, Masood A, Alanazi I, Alradwan I, Majrashi M, et al. Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona. Sci Rep. 2017;7:10542 pubmed publisher
    ..Interestingly, HA-CS NPs differentially adsorbed two unique anti-inflammatory proteins (ITIH4 and AGP), which were absent from the PC of both controls...
  34. Tozaki T, Choi Miura N, Taniyama M, Kurosawa M, Tomita M. SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method. BMC Med Genet. 2002;3:6 pubmed
    ..Single-nucleotide polymorphisms (SNPs) of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene were analyzed using a fluorescence-adapted SSCP method...
  35. Tanaka H, Shimazawa M, Takata M, Kaneko H, Tsuruma K, Ikeda T, et al. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis. J Neurol. 2013;260:1782-97 pubmed publisher
    ..selected clear protein spots and identified two candidate proteins-inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and glutathione peroxidase 3 (Gpx3)...
  36. Kim M, Gu B, Song S, Choi B, Cha D, Baek K. ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients. Mol Biosyst. 2011;7:1430-40 pubmed publisher
    ..These findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools. ..
  37. Li X, Li B, Li B, Guo T, Sun Z, Li X, et al. ITIH4: Effective Serum Marker, Early Warning and Diagnosis, Hepatocellular Carcinoma. Pathol Oncol Res. 2018;24:663-670 pubmed publisher
    ..Through MS/MS identification, it is confirmed that the polypeptide is inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4). The serum ITIH4 concentrations in two groups were measured with ELISA and compared with Alpha-fetoprotein (AFP)...
  38. Lee K, Feng P, Ho S, Chuang K, Chen T, Su C, et al. Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015;10:831-41 pubmed publisher
    ..with the same in healthy controls and included proteoglycan 4 (PRG4), inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), and apolipoprotein F (APOF). PRG4 and ITIH4 were associated with a past 3-year PM10 exposure level...
  39. Canter M, Graham C, Heit M, Blackwell L, Wilkey D, Klein J, et al. Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects. Am J Obstet Gynecol. 2008;198:553.e1-6 pubmed publisher
    ..The purpose of this study was to identify differences in urine proteins between patients with interstitial cystitis (IC) and asymptomatic control (AC) subjects with the use of proteomic techniques...
  40. . Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011;43:969-76 pubmed publisher
    ..0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)).
  41. Li Z, Xiang Y, Chen J, Li Q, Shen J, Liu Y, et al. Loci with genome-wide associations with schizophrenia in the Han Chinese population. Br J Psychiatry. 2015;207:490-4 pubmed publisher
    ..We detected the first genome-wide significant association of schizophrenia with CALN1, which is a predicted target of MIR137, and thus provide new evidence for the associations between MIR137 targets and schizophrenia. ..
  42. Gao S, Yang W, Yu H, Liu R, Dong Z, Zhang H, et al. Significant changes in ITIH4, AHSG, ORM1, and CD46 content in milk fat globule membrane proteins of ketotic dairy cows. J Dairy Res. 2017;84:407-413 pubmed publisher
    ..C3 (C3), prothrombin (F2), alpha-1-acid glycoprotein (ORM1), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), alpha-2-HS-glycoprotein (AHSG), complement C9 (C9), complement regulatory protein variant 4 (CD46)) in ..
  43. Soury E, Olivier E, Daveau M, Hiron M, Claeyssens S, Risler J, et al. The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human. Biochem Biophys Res Commun. 1998;243:522-30 pubmed
    ..Therefore, in contrast to what is seen for the ITIH1 to -3 genes, the rat and human ITIH4 gene transcriptions and products thereof present marked differences, which suggests species-specific functions for ..
  44. Fernandes M, Husi H. Integrative Systems Biology Investigation of Fabry Disease. Diseases. 2016;4: pubmed publisher
    ..Differential expression of acute-phase response proteins in the groups of naïve (up-regulation of ORM1, ORM2, ITIH4, SERPINA3 and FGA) and ERT (down-regulation of FGA, ORM1 and ORM2) patients could be potential hallmarks for ..
  45. Noh C, Kim S, Kim D, Lee H, Cho H, Yoon S, et al. Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma. Clin Biochem. 2014;47:1257-61 pubmed publisher
    Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is associated with various diseases...
  46. Fujita Y, Ezura Y, Emi M, Sato K, Takada D, Iino Y, et al. Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. J Hum Genet. 2004;49:24-8 pubmed
    ..between a C/T single nucleotide polymorphism at IVS17+8 in the inter-alpha-trypsin inhibitor heavy chain 4 gene (ITIH4) and plasma total cholesterol levels in 351 adult individuals from an east-central area of Japan...
  47. Kashyap R, Nayak A, Deshpande P, Kabra D, Purohit H, Taori G, et al. Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke. Clin Chim Acta. 2009;402:160-3 pubmed
    ..In addition, we investigated how the identified protein compared with protein S-100betabeta, neuron-specific enolase (NSE), and cytokine interleukins IL-2 and IL-10...
  48. Amare A, Schubert K, Klingler Hoffmann M, Cohen Woods S, Baune B. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. Transl Psychiatry. 2017;7:e1007 pubmed publisher
  49. Diarra Mehrpour M, Sarafan N, Bourguignon J, Bonnet F, Bost F, Martin J. Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. J Biol Chem. 1998;273:26809-19 pubmed
    ..We determined that the human ITIH1, ITIH3, and ITIH4 genes are closely linked within a 45-kilobase pair...
  50. Fu J, Li G, Li L, Yin J, Cheng H, Han L, et al. The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study. Oncotarget. 2017;8:93593-93607 pubmed publisher
    ..004) and MAP2K5-rs4776970 (P = 0.004), with odds ratios ranging from 1.211 to 1.421; while ITIH4-rs2535633 and BDNF-rs2030323 yielded nominal association with the same trait (P < 0.05)...