ITGB5

Summary

Gene Symbol: ITGB5
Description: integrin subunit beta 5
Alias: integrin beta 5, integrin, beta 5
Species: human

Top Publications

  1. pmc A NPxY-independent beta5 integrin activation signal regulates phagocytosis of apoptotic cells
    Sukhwinder Singh
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103 6399, USA
    Biochem Biophys Res Commun 364:540-8. 2007
  2. doi Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of alphavbeta5 integrin activation
    Immacolata Vocca
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, National Research Council, via Castellino, 111, Naples, Italy
    Int J Cancer 124:316-25. 2009
  3. ncbi Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 163:1929-35. 1999
  4. ncbi Myosin-X provides a motor-based link between integrins and the cytoskeleton
    Hongquan Zhang
    Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology F46, Karolinska University Hospital Huddinge, SE 141 86 Huddinge, Sweden
    Nat Cell Biol 6:523-31. 2004
  5. pmc A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin
    B E Vogel
    La Jolla Cancer Research Foundation, California 92037
    J Cell Biol 121:461-8. 1993
  6. ncbi Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
    M V Carriero
    National Cancer Institute, Naples, Italy
    Cancer Res 59:5307-14. 1999
  7. pmc Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors alphaV and beta5
    Jennifer C Y Wong
    Diabetes Transplant Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
    Cell Adh Migr 4:39-45. 2010
  8. ncbi Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 126:1761-9. 2006
  9. pmc p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration
    Zhilun Li
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
    J Biol Chem 285:23699-710. 2010
  10. pmc P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration
    Hongquan Zhang
    Karolinska Institutet, Department of Microbiology, Pathology, and Immunology, SE 141 86 Huddinge, Sweden
    J Cell Biol 158:1287-97. 2002

Research Grants

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. pmc A NPxY-independent beta5 integrin activation signal regulates phagocytosis of apoptotic cells
    Sukhwinder Singh
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103 6399, USA
    Biochem Biophys Res Commun 364:540-8. 2007
    ....
  2. doi Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of alphavbeta5 integrin activation
    Immacolata Vocca
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, National Research Council, via Castellino, 111, Naples, Italy
    Int J Cancer 124:316-25. 2009
    ..These results shed light on the regulation of cell migration by uPA phosphorylation and provide a realistic opportunity for a novel antiinvasive/metastatic therapeutic intervention...
  3. ncbi Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 163:1929-35. 1999
    ....
  4. ncbi Myosin-X provides a motor-based link between integrins and the cytoskeleton
    Hongquan Zhang
    Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology F46, Karolinska University Hospital Huddinge, SE 141 86 Huddinge, Sweden
    Nat Cell Biol 6:523-31. 2004
    ..Taken together, these results indicate that Myo10-mediated relocalization of integrins might serve to form adhesive structures and thereby promote filopodial extension...
  5. pmc A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin
    B E Vogel
    La Jolla Cancer Research Foundation, California 92037
    J Cell Biol 121:461-8. 1993
    ..These data define an auxiliary integrin binding specificity for basic amino acid sequences. These basic domain binding sites may function synergistically with the binding sites that recognize RGD or equivalent sequences...
  6. ncbi Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
    M V Carriero
    National Cancer Institute, Naples, Italy
    Cancer Res 59:5307-14. 1999
    ..These data show that uPAR association with alpha(v)beta5 leads to a functional interaction of these receptors and suggest that uPAR directs cytoskeletal rearrangements and cell migration by altering alpha(v)beta5 signaling specificity...
  7. pmc Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors alphaV and beta5
    Jennifer C Y Wong
    Diabetes Transplant Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
    Cell Adh Migr 4:39-45. 2010
    ..This suggested a potential role of vitronectin binding integrins in the development of definitive endoderm...
  8. ncbi Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 126:1761-9. 2006
    ..Anti-alphavbeta5 antibody reversed the myofibroblastic features of LSc fibroblasts. These results indicate that upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in LSc fibroblasts...
  9. pmc p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration
    Zhilun Li
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
    J Biol Chem 285:23699-710. 2010
    ..Our results may give important leads to the functional regulation of integrin alphavbeta5, with implications for vascular permeability, angiogenesis, and cancer dissemination...
  10. pmc P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration
    Hongquan Zhang
    Karolinska Institutet, Department of Microbiology, Pathology, and Immunology, SE 141 86 Huddinge, Sweden
    J Cell Biol 158:1287-97. 2002
    ..Yeast two-hybrid screening identified PAK4 binding to the cytoplasmic domain of the integrin beta 5 subunit, an association that was also found in mammalian cells between endogenous PAK4 and integrin alpha v ..
  11. doi Overexpression of integrin beta 5 enhances the paracrine properties of circulating angiogenic cells via Src kinase-mediated activation of STAT3
    Maren Leifheit-Nestler
    Department of Cardiology and Pulmonology, Georg August University, Goettingen, Germany
    Arterioscler Thromb Vasc Biol 30:1398-406. 2010
    ..To determine the intracellular mechanisms mediating the angiogenic effects of integrin alpha v beta 5 overexpression in circulating angiogenic cells (CACs)...
  12. ncbi The alphavbeta5 integrin functions as an endocytic receptor for vitronectin
    L M Memmo
    Cell and Molecular Biology Program, Albany Medical College, Albany, New York 12208, USA
    J Cell Sci 111:425-33. 1998
    ..This study provides the first evidence that the alphavbeta5 vitronectin receptor directly mediates the internalization of vitronectin...
  13. pmc Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
    Brian P Eliceiri
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:149-60. 2002
    ..Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin alpha(v)beta5 into a FAK-containing signaling complex during growth factor-mediated biological responses...
  14. ncbi Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit
    J Liliental
    Department of Medicine, Microbiology and Immunology, University of California at Los Angeles School of Medicine 90095, USA
    J Biol Chem 273:2379-83. 1998
    ..These findings suggest that Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions...
  15. ncbi Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin
    S C Even-Ram
    Departments of Oncology and Pharmacology at the Hadassah Hebrew University Hospital, Jerusalem 91120, Israel, The Department of Hematology, Medical Center, Tel Aviv 64239, Israel
    J Biol Chem 276:10952-62. 2001
    ..We propose that the activation of PAR1 may lead to a novel cooperation with the alpha(v)beta(5) integrin that supports tumor cell invasion...
  16. ncbi A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5
    D D Hu
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037, USA
    J Biol Chem 270:26232-8. 1995
    ..Collectively, these findings prove that integrins alpha v beta 1, alpha v beta 3, and alpha v beta 5 have similar affinity for OPN. Therefore, all three integrins must be considered when evaluating the biological affects of OPN...
  17. ncbi Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β
    Anna Bianchi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 9:1647-59. 2010
    ..Finally, depletion of β5-integrin significantly reduced invasiveness of breast carcinoma cells. Thus, the β5-integrin adhesions contribute to the TGFβ-induced EMT and the tumorigenic potential of carcinoma cells...
  18. pmc Cloning, primary structure and properties of a novel human integrin beta subunit
    H Ramaswamy
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:1561-8. 1990
    ..By immunoprecipitation, beta 5 was most prevalent on carcinoma cell lines, was also present on hepatoma and fibroblast cell lines, and was absent from lymphoblastoid cells and platelets...
  19. pmc Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes
    J C Adams
    Keratinocyte Laboratory, Imperial Cancer Research Fund, London, England
    J Cell Biol 115:829-41. 1991
    ..ndk thus have a number of characteristics that distinguish them from normal basal keratinocytes...
  20. pmc The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression
    Hisaki Hayashi
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232 6300, USA
    J Biol Chem 283:23791-800. 2008
    ..molecules associated with cell-extracellular matrix interactions, integrin beta3 (Itgb3), integrin beta5 (Itgb5), and fibronectin, as downstream targets of Foxc2...
  21. ncbi [Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin]
    Chao Qin Yu
    Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhong Xi Yi Jie He Xue Bao 7:41-7. 2009
    ..To observe the inhibitory effects of puerarin on angiopoiesis of endometriotic tissue, and to explore the regulatory effects of puerarin on tumor-related gene expression of endometriosis...
  22. ncbi Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes
    Tatyana I Gudz
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 22:7398-407. 2002
    ..These data establish a novel function for PLP as a part of the integrin signaling complex in oligodendrocytes and suggest that neurotransmitter-mediated integrin receptor signaling may be involved in myelinogenesis...
  23. pmc c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5
    Xiuhai Ren
    Division of Hematology Oncology, Department of Pediatrics, Keck School of Medicine, University of Southern California and The Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e42291. 2012
    ..These studies implicate ASM as a mediator of apoptosis induced by inhibition of integrins αvβ3/αvβ5, and for the first time place c-Abl as an upstream regulator of ASM expression and activity...
  24. pmc Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina
    Linda Ruggiero
    Department of Biological Sciences, Center for Cancer, Genetic Diseases, and Gene Regulation, Fordham University, Bronx, NY 10458, USA
    Proc Natl Acad Sci U S A 109:8145-8. 2012
    ..Moreover, our results demonstrate that the diurnal rhythm of PS demarcation of POS tips is not intrinsic to rod photoreceptors but requires activities of the RPE as well...
  25. pmc Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival
    Anne E Conway
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92037, USA Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92037, USA Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Rep 15:666-79. 2016
    ..For cell adhesion, we find IMP1 maintains levels of integrin mRNA specifically regulating RNA stability of ITGB5 in hPSCs. Additionally, we show that IMP1 can be linked to hPSC survival via direct target BCL2...
  26. pmc Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor
    DeannaLee M Beauvais
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Exp Med 206:691-705. 2009
    ..Thus, Sdc1 is a critical regulator of these two important integrins during angiogenesis and tumorigenesis, and is inhibited by the novel SSTN peptide...
  27. ncbi Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing
    Cristiane G Lin
    Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 280:8229-37. 2005
    ..These findings, together with its angiogenic activity, support a role for CCN3 in cutaneous wound healing in skin fibroblasts and establish its matricellular mode of action through integrin receptors...
  28. doi Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis
    Jinpiao Lin
    Shanghai Institute of Immunology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Immunol 188:5776-84. 2012
    ..Our study also suggests that targeting of Cyr61 may represent a novel strategy in RA treatment...
  29. doi αvβ3, αvβ5 and αvβ6 integrins in brain metastases of lung cancer
    Anna Sophie Berghoff
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    Clin Exp Metastasis 31:841-51. 2014
    ..Expression of αv integrin subunits seem to be of pathobiological and clinical relevance in patients with NSCLC BM. Further investigations of their involvement in the brain metastatic cascade and their role as biomarkers are warranted...
  30. pmc Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion
    Elizabeth K Duperret
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, BRB 1010, 421 Curie Blvd, Philadelphia, PA 19104, USA
    J Cell Sci 128:3997-4013. 2015
    ..These phenotypes depend only on the binding partners of integrin-αv--integrin β5 and integrin β6 (also known as ITGB5 and ITGB6, respectively)...
  31. ncbi Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain
    S L Nishimura
    Department of Medicine, University of California at San Francisco 94143
    J Biol Chem 269:28708-15. 1994
    ..We conclude that the beta 8 cytoplasmic domain, which is structurally unrelated to the conserved cytoplasmic domains of other beta subunits, is functionally distinct...
  32. doi FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1
    Jinxia Hu
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing 100191, China State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, China Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264000, Shandong, China
    FEBS Lett 588:4348-56. 2014
    ..Taken together, these findings demonstrate that the putative tumor suppressive protein FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin β5 tail and to ROCK1. ..
  33. ncbi HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes
    R M Lafrenie
    Laboratories of Developmental Biology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA
    J Immunol 157:974-7. 1996
    ....
  34. pmc Transforming growth factor-beta (TGF- β) signaling in paravertebral muscles in juvenile and adolescent idiopathic scoliosis
    Roman Nowak
    Department of Orthopedics, School of Medicine with the Division of Dentistry, Medical University of Silesia, Wojewódzki Szpital Specjalistyczny nr 5 Plac Medyków 1, 41 200 Sosnowiec, Poland
    Biomed Res Int 2014:594287. 2014
    ..overrepresentation of the genes localized in the extracellular region of curve concavity: LTBP3, LTBP4, ITGB4, and ITGB5. This finding suggests the extracellular region of paravertebral muscles as an interesting target for future ..
  35. pmc Combinatorial fibronectin and laminin signaling promote highly efficient cardiac differentiation of human embryonic stem cells
    Silin Sa
    Graduate Group in Biological Engineering and Small scale Technologies, University of California, Merced, California
    Biores Open Access 3:150-61. 2014
    ..Moreover, the LN receptor integrin β4 (ITGB4) and FN receptor integrin β5 (ITGB5) genes, jointly with increased phosphorylated focal adhension kinase and phosphorylated extracellular signal-..
  36. doi FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration
    Yuqing Liu
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing 100191, China State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, China
    FEBS Lett 588:2859-66. 2014
    ..Functionally, Myo7a-induced cell adhesion and migration were mediated by integrin αvβ5. These findings indicated that Myo7a interacts with integrin β5 and selectively promotes integrin αvβ5-mediated cell migration. ..
  37. doi Enhancement of RANKL-induced MITF-E expression and osteoclastogenesis by TGF-β
    Kumiko Asai
    Laboratory of Molecular Biology, Azabu University School of Veterinary Medicine, Sagamihara, Japan
    Cell Biochem Funct 32:401-9. 2014
    ..the expression of dendritic cell-specific transmembrane protein (DC-STAMP), Itgav, Itga2, Itga5, Itgb1, Itgb3 and Itgb5, genes related to cell adhesion and fusion, were up-regulated by co-treatment with TGF-β...
  38. pmc Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β
    Anna Bianchi-Smiraglia
    Department of Cancer Genetics Roswell Park Cancer Institute Buffalo, NY USA
    Cell Cycle 12:3377-89. 2013
    ..These findings provide a platform for defining the molecular mechanism regulating the organization and activities of VSFs in response to TGF-β. ..
  39. pmc Role of genetic susceptibility to latent adenoviral infection and decreased lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Respir Med 103:1672-80. 2009
    ..The receptor for adenovirus (CXADR) and integrin beta(5) (ITGB5) are host factors which might affect adenovirus infection...
  40. pmc ATG proteins mediate efferocytosis and suppress inflammation in mammary involution
    Irina Teplova
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Autophagy 9:459-75. 2013
    ..apoptotic bodies, but were defective phagocytes in association with reduced expression of the MERTK and ITGB5 receptors, thus pointing to defective apoptotic body engulfment...
  41. ncbi [Correlation of cell apoptosis induction with expression of human beta5 integrin on hematopoietic cells]
    L Yin
    Department of Pathophysiology, Shanghai Medical University, Shanghai 200032, China
    Zhonghua Xue Ye Xue Za Zhi 22:13-6. 2001
    ..To investigate the function of alpha(v)beta5 integrin in hematopoietic cells...
  42. doi Expression of mesenchymal-related genes by the bovine trophectoderm following conceptus attachment to the endometrial epithelium
    Sachiko Yamakoshi
    Laboratory of Animal Breeding, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Reproduction 143:377-87. 2012
    ..alpha 8 (ITGA8), integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3), and integrin, beta 5 (ITGB5) mRNAs on day 22...
  43. pmc A genome-wide association study identifies two novel promising candidate genes affecting Escherichia coli F4ab/F4ac susceptibility in swine
    Wei Xuan Fu
    Key Laboratory of Animal Genetics Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China
    PLoS ONE 7:e32127. 2012
    ..From these significant findings, two novel candidate genes, HEG1 and ITGB5, were firstly identified as the most promising genes underlying F4ab/F4ac susceptibility in swine according to ..
  44. pmc Degradation of internalized αvβ5 integrin is controlled by uPAR bound uPA: effect on β1 integrin activity and α-SMA stress fiber assembly
    Lingyan Wang
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e33915. 2012
    ..Our data support a novel mechanism by which downregulation of uPA/uPAR results in increased integrin αvβ5 cell-surface protein levels that regulate the activity of β1 integrins, promoting characteristics of the persistent Mf...
  45. pmc Androgen receptor-target genes in african american prostate cancer disparities
    Bi Dar Wang
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Prostate Cancer 2013:763569. 2013
    ..Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities...
  46. pmc CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway
    Shan Chi Liu
    Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
    PLoS ONE 7:e51097. 2012
    ..CTGF is abundantly expressed in osteoarthritis (OA). However, the relationship between CTGF and IL-6 in OA synovial fibroblasts (OASFs) is mostly unknown...
  47. pmc Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways
    A Bianchi-Smiraglia
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Oncogene 32:3049-58. 2013
    ....
  48. doi Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells
    Mee Song
    Cellular and Molecular Toxicology Laboratory, Center for Integrated Risk Research, Korea Institute of Science and Technology KIST, P O BOX 131, Cheongryang, Seoul, Republic of Korea
    Arch Toxicol 87:1103-13. 2013
    ..The expression levels of 10 of these genes (ID2, ID3, CCL2, TBX3, TGOLN2, C1orf71, ZNF676, GULP1, KLF9, and ITGB5) were altered by deiodinase-disrupting chemicals (2,3,7,8-tetrachlorodibenzo-p-dioxin, polychlorinated biphenyls, ..
  49. pmc The matrix protein CCN1/CYR61 is required for α(V)β5-mediated cancer cell migration
    Jana Jandova
    Department of Medicine, Dermatology Division, University of Arizona, Tucson, AZ 85724, USA
    Cell Biochem Funct 30:687-95. 2012
    ..These results represent an advance to the understanding of the role of CYR61 and α(V)β5 integrin as proteins that cooperate to mediate cancer cell migration...
  50. doi Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis
    Feng Li
    Department of Otolaryngology Head and Neck Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, PR China
    Pathol Res Pract 209:105-9. 2013
    ..Among the members of integrin αv subfamily, integrin αvβ5 might play an important role in invasion and metastases of the LSCC, and it may become a valuable marker for the evolution of the LSCC...
  51. doi Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin αvβ5-induced secretion of VEGF-A
    Anna Desch
    Division of Experimental Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Pathol 181:693-705. 2012
    ..In conclusion, these results indicate an important role of VEGF-A in acute endothelium activation and provide clear evidence that MMP-2 plays a pivotal role in the autocrine regulation of VEGF-A expression in melanoma cells...
  52. pmc Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells
    Stefan Rieken
    University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, Germany
    Radiat Oncol 6:132. 2011
    ..This study was set up to describe mechanisms underlying increased glioma cell migration through photon irradiation and to analyse the modifiability of photon-altered glioma cell motility by integrin inhibition...
  53. doi Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells
    Wen Yi Hung
    Department and Institute of Pharmacology, School of Medicine, National Yang Ming University, and Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochim Biophys Acta 1820:1102-10. 2012
    ..Mitochondrial dysfunction has been shown to promote cancer cell migration. However, molecular mechanism by which mitochondrial dysfunction enhances gastric cancer (GC) cell migration remains unclear...
  54. pmc Integrin and defensin modulate the mechanical properties of adenovirus
    Joost Snijder
    Natuur en Sterrenkunde and LaserLab, VU University, Amsterdam, The Netherlands
    J Virol 87:2756-66. 2013
    ..Host factors that influence adenovirus infectivity thus modulate the elastic properties of the capsid. Our findings reveal a direct link between virus-host interactions and capsid mechanics...
  55. doi Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective alpha(v)beta (5) integrin ligand
    A Trabocchi
    Dipartimento di Chimica Organica Ugo Schiff, Polo Scientifico di Sesto Fiorentino, Universita degli Studi di Firenze, Sesto Fiorentino, Florence, Italy
    Amino Acids 38:329-37. 2010
    ....
  56. doi Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin
    Teisha J Rowland
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California 93106, USA
    Stem Cells Dev 19:1231-40. 2010
    ..These studies suggest that vitronectin, or derivatives thereof, might substitute for Matrigel in a more defined system for iPSC culture...
  57. doi Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface
    Dana A Massuto
    Departments of Veterinary Integrative Biosciences Veterinary Large Animal Clinical Sciences Animal Science, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 139:465-78. 2010
    ..10, 12, 16, 20, and 24 pregnant gilts were immunostained for TGFB, LAP, and ITG subunits (ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8)...
  58. doi Gene expression profile towards the prediction of patient survival of gastric cancer
    Zhen Yu Xu
    Biomed Pharmacother 64:133-9. 2010
    ..However, the prognostic gene lists have overlapped poorly until now. This study conducted an analysis to characterize gene expression profile and developed a survival prediction model...
  59. doi Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation
    D Lane
    Departement De Microbiologie et Infectiologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Canada
    Oncogene 29:3519-31. 2010
    ..These results suggest that ovarian cancer ascites induces FAK and Akt activation in an alphavbeta5 integrin-dependent pathway, which confers protection from TRAIL-induced cell death and caspase activation...
  60. ncbi Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin
    J W Smith
    Department of Immunology IMM13, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Biol Chem 265:11008-13. 1990
    ..Secondly, polyclonal antibodies raised against alpha v beta 5 immunoprecipitate both beta 5 and beta x, and finally, the amino-terminal amino acid sequences of beta x and beta 5 are identical...
  61. pmc Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells
    Cynthia Lyle
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Virol J 7:148. 2010
    ..However, a number of studies reporting data which conflicts with this simple model have been published. These observations have led us to question the proposed two-step model for adenovirus infection...
  62. doi Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin
    Toshiaki Yoshioka
    Department of Molecular Pathology and Tumor Pathology, Akita University Graduate School of Medicine, Akita, Japan
    Cancer Sci 101:2011-8. 2010
    ..Our study suggests that hepatocyte-derived HRG might participate in a highly liver-metastatic phenotype of LS-LM6 through enhancement of integrin αvβ5-mediated cell migration and erbB3/erbB2 signaling...
  63. doi β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication
    Ester Ballana
    IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
    J Immunol 186:464-70. 2011
    ..Importantly, such inhibition did not induce changes in cell adhesion to the substrate. In conclusion, our results reveal a significant role of the integrin dimer α(v)β(5) in HIV-1 infection of macrophages...
  64. doi CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway
    Huey En Tzeng
    Division of Hematology Oncology, Taichung Veterans General Hospital, Taichung, Taiwan
    J Cell Physiol 226:3181-9. 2011
    ..Taken together, our results indicate that CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the αvβ3/αvβ5 integrin receptor, FAK, PI3K, Akt, p65, and NF-κB signal transduction pathway...
  65. pmc Prion protein expression regulates embryonic stem cell pluripotency and differentiation
    Alberto Miranda
    Departamento de Reproducción Animal y Conservación de Recursos Zoogenéticos, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Madrid, Spain
    PLoS ONE 6:e18422. 2011
    ..In addition, antibody-mediated inhibition of ITGB5 (integrin αvβ5) in the KO line rescued the low expression of Nanog on Day 5, suggesting the regulation of Nanog ..
  66. pmc Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover
    Zhilun Li
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
    Mol Biol Cell 21:3317-29. 2010
    ..We thus demonstrate a novel mechanism deployed by cells to tune cell adhesion levels through the autoinhibitory regulation of integrin adhesion...
  67. pmc Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit
    S Suzuki
    Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles
    Proc Natl Acad Sci U S A 87:5354-8. 1990
    ..The beta subunit described herein seems to be identical to the beta x subunit and to function as the beta subunit of a vitronectin receptor...
  68. pmc Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
    Guohong Li
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, United States
    Atherosclerosis 208:358-65. 2010
    ..These results reveal a mechanism whereby PN mediates vascular SMC migration through an interaction with alphaV-integrins (mainly alphanubeta3) and subsequent activation of FAK pathway...
  69. ncbi Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769
    Ei Kawahara
    Department of Laboratory Sciences, School of Health Sciences, Kanazawa University Faculty of Medicine, 5 11 80 Kodatsuno, Kanazawa 920 0942, Japan
    Cell Biol Int 29:521-8. 2005
    ..CHO cells transfected with single-FNK and repeated-FNK showed similar adhesiveness to, and proliferative activity on, vitronectin substrates...
  70. pmc Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling
    David A Calderwood
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:2272-7. 2003
    ..These data establish that short integrin beta tails interact with a large number of PTB domain-containing proteins through a structurally conserved mechanism...
  71. ncbi Characterization of the expression of key adenoviral receptors CAR and integrin beta3/beta5 subunits on the membrane of human NT2 neurons
    Deqi Huang
    Experimental Stroke Group, NRC Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Mol Neurosci 24:323-8. 2004
    ..These observations suggest that modulating the expression of integrin subunits beta3/5 or the functional heterodimer alphavbeta3/5 in human NT2/Ns may enhance adenoviral infectivity of NT2/Ns...
  72. ncbi Smooth muscle contraction and relaxation
    R Clinton Webb
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Adv Physiol Educ 27:201-6. 2003
    ..Removal of Ca(2+) from the cytosol and stimulation of myosin phosphatase initiate the process of smooth muscle relaxation...
  73. ncbi Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V
    Marina Cardo-Vila
    M D Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell 11:1151-62. 2003
    ..Our results suggest a functional link between the alpha v beta 5 integrin, annexin V, and programmed cell death. We propose the term "endothanatos" to designate this phenomenon...
  74. ncbi Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling
    Haifeng Zhang
    National University Medical Institutes, Clinical Research Centre, Blk MD11, 10 Medical Drive, Singapore 117597, Singapore
    FEBS Lett 532:171-6. 2002
    ..NF-kappaB activation by TLR2/1, TLR2/6 and the TLR4 monomer, but not TLR4/4, was completely inhibited by dominant negative MyD88, suggesting that TLR4 homodimers and monomers could activate NF-kappaB through different mechanisms...
  75. pmc The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3
    Steven B Ludbrook
    Department of Systems Research, GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage SG1 2NY, U K
    Biochem J 369:311-8. 2003
    ..Furthermore, they are important as they link alpha(v)beta(3) and TGFbeta, which may have implications in cancer and a number of inflammatory and fibrotic diseases where expression of both proteins has been documented...
  76. ncbi Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrin
    Jung Eun Kim
    Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
    J Biol Chem 277:46159-65. 2002
    ..This suggests that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins...
  77. ncbi Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization
    J P Evans
    Department of Biochemistry and Molecular Biology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 615 N Wolfe St, Room 3606A, Baltimore, MD 21205, USA
    Bioessays 23:628-39. 2001
    ..Key issues in cell adhesion that pertain to gametes and fertilization will also be highlighted...
  78. ncbi cDNA sequence of the human integrin beta 5 subunit
    J W McLean
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080
    J Biol Chem 265:17126-31. 1990
    ....
  79. ncbi CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain
    T M Grzeszkiewicz
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    J Biol Chem 276:21943-50. 2001
    ..Together, these findings establish CYR61 as a novel ligand for integrin alpha(v)beta(5) and show that CYR61 interacts with distinct integrins to mediate disparate activities in a cell type-specific manner...
  80. ncbi MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin
    M Zhou
    Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
    Biochem Biophys Res Commun 280:574-80. 2001
    ..These data indicated that the disintegrin domain of MDC-9 can function as an adhesion molecule by interacting with an alpha(v)beta(5) integrin...
  81. ncbi alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells
    M L Albert
    Laboratory of Neuro Oncology, Rockefeller University, 1230 York Avenue, Box 226 New York 10021, USA
    Nat Cell Biol 2:899-905. 2000
    ....
  82. pmc Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells
    V Cirulli
    The Islet Research Laboratory at The Whittier Institute for Diabetes, La Jolla, California, USA
    J Cell Biol 150:1445-60. 2000
    ..Thus, these data provide the first evidence for the contribution of integrins alpha(v)beta(3) and alpha(v)beta(5) and their ligands to morphogenetic events in the human endocrine pancreas...
  83. ncbi Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney
    H Rabb
    Department of Internal Medicine, James A Haley Veterans Hospital, Tampa, FL 33612, USA
    Am J Nephrol 16:402-8. 1996
    ..Variations in alpha v beta 3-and alpha v beta 5-integrin expression may play a role in normal and neoplastic processes of the kidney...
  84. ncbi Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:17-28. 2006
    ..Overexpression of FHL2 increases the accumulation of osteoblast differentiation markers and matrix mineralization, whereas FHL2 deficiency results in inhibition of osteoblast differentiation and decreased bone formation...
  85. ncbi Expression of integrins in cerebral arteriovenous and cavernous malformations
    Askin Seker
    Department of Neurosurgery, Institute of Neurological Sciences, Marmara University, Istanbul, Turkey
    Neurosurgery 58:159-68; discussion 159-68. 2006
    ..To assess and compare levels and patterns of expression for integrins alphavbeta1, alphavbeta3, and alphavbeta5 in arteriovenous malformations (AVMs) and cavernous malformations (CCMs) of the brain...
  86. pmc The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function
    Mojca Skoberne
    New York University School of Medicine, 550 First Ave, MSB 507, New York, NY 10016, USA
    Blood 108:947-55. 2006
    ..This immunomodulatory role, however, is countered by a significant inflammatory stimulus such as bacterial infection. Overall, our data suggest that under steady-state conditions, signaling via CRs predominates to render DCs tolerogenic...
  87. doi Phenotypic and gene expression diversity of malignant cells in human blast crisis chronic myeloid leukemia
    Masha Simanovsky
    Division of Hematology and Bone Marrow Transplantation, Laboratory of Molecular Immunobiology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Differentiation 76:908-22. 2008
    ..up-regulation of the oncogenes BCR-ABL, c-JUN, and c-FOS along with the adhesion-related genes KiSS-1, THBS3, and ITGB5. The adherent blasts stably retain their unique properties even after elimination of the adherence selection ..
  88. pmc PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins
    Daniel Vial
    Center for Cell Biology and Cancer Research MC 165, Albany Medical College, Albany, NY 12208, USA
    J Cell Sci 121:1661-70. 2008
    ..Our data identify PAI1 as a novel regulator of fibronectin matrix assembly, and indicate that this regulation occurs through a previously undescribed crosstalk between the alphavbeta5 and alpha5beta1 integrins...
  89. doi CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation
    Natalie J Hannan
    Prince Henry s Institute of Medical Research, Clayton, 3168 Victoria, Australia
    Biol Reprod 79:58-65. 2008
    ..protein 1 (ECM1), osteopontin (SPP1), integrin alpha 6 (ITGA6), matrix metalloproteinase 12 (MMP12), and integrin beta 5 (ITGB5) following chemokine treatment. Several of these genes have previously been implicated in implantation...
  90. doi Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma
    Akira Kurokawa
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 112:1272-81. 2008
    ..The objective of the current study was to identify biomarkers that reflect the clinical course of squamous cell carcinoma of the tongue (TSCC)...
  91. ncbi Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression
    Sharada D Vangipuram
    Children s Research Center of Michigan, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine and Children s Hospital of Michigan, Detroit, MI 48201, USA
    Alcohol Clin Exp Res 32:339-47. 2008
    ..To date, the cellular targets and mechanisms responsible for FASD are not fully characterized. Our aim was to determine if ETOH can affect fetal human brain-derived neural progenitor cells (NPC)...
  92. ncbi Cell surface overexpression of alphavbeta5 integrin impedes alphavbeta3-mediated migration of the human ovarian adenocarcinoma cell line IGROV1
    Sylvie Maubant
    GRECAN, Université de Caen Basse Normandie and Centre de Lutte Contre le Cancer François Baclesse, Avenue du General Harris, 14076 Caen Cedex 05, France
    Cell Biol Int 31:109-18. 2007
    ..Finally, the response to cisplatin was not significantly modified in beta5 transfectants when compared to IGROV1 parental cells...
  93. ncbi betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
    Byung Heon Lee
    Department of Biochemistry and Cell and Matrix Biology Research Institute, School of Medicine, Kyungpook National University, Daegu 700 422, Korea
    Exp Mol Med 38:153-61. 2006
    ..Taken together, these results suggest that betaig-h3 and alphavbeta5 integrin play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis...
  94. ncbi Transcriptosome and serum cytokine profiling of an atypical case of myelodysplastic syndrome with progression to acute myelogenous leukemia
    Daruka Mahadevan
    University of Arizona Cancer Center, Tucson, Arizona 85724, USA
    Am J Hematol 81:779-86. 2006
    ..oncogenes (HOXA9, N-MYC, KOC1), proliferative genes (PAWR, DLG5, AKR1C3), invasion/metastatic genes (FN1, N-CAM-1, ITGB5), pro-angiogenesis genes (c-Kit), and down regulation of tumor suppressor genes (SUI1, BARD1) and anti-apoptotic ..
  95. doi Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker
    Annika Brendle
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 29:1394-9. 2008
    ..polymorphisms (SNPs) in predicted miRNA target sites of six integrin genes (ITGA3, ITGA6, ITGAv, ITGB3, ITGB4 and ITGB5) on breast cancer (BC) risk and clinical outcome...
  96. ncbi Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene
    Maria Carla Bosco
    Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
    J Immunol 177:1941-55. 2006
    ..MSR1, MARCO, TLR7), immunoregulatory, costimulatory, and adhesion molecules (CD32, CD64, CD69, CD89, CMRF-35H, ITGB5, LAIR1, LIR9), chemokines/cytokines and receptors (CCL23, CCL15, CCL8, CCR1, CCR2, RDC1, IL-23A, IL-6ST)...
  97. ncbi Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells
    F de Nigris
    Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Naples, Italy
    Oncogene 26:382-94. 2007
    ..YY1 regulated negatively the Myc activity through a direct interaction with the Myc/Max and deacetylase complexes. This represents a novel silencing mechanism with broad implications in the transcription machinery of tumours...
  98. doi Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy
    Robert C Burghardt
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Reproduction 137:567-82. 2009
    ..on days 40, 80, or 120 of pregnancy, and uteri immunostained for integrins (ITGAV, ITGA4, ITGA5, ITGB1, ITGB3, and ITGB5), ECM proteins (SPP1, LGALS15, fibronectin (FN), and vitronectin (VTN)), cytoskeletal molecules (ACTN and TLN1), ..
  99. ncbi Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin
    Yasuyuki Yokosaki
    Molecular Division, Department of Public Health, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minamiku, Hiroshima, 734 8551, Japan
    Matrix Biol 24:418-27. 2005
    ..These results suggest that the hierarchy of integrin interactions with osteopontin can undergo complex regulation at least in part through the action of extracellular proteases...
  100. pmc The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis
    Sallouha Aidoudi
    INSERM, U920, Talence, France
    PLoS ONE 3:e2657. 2008
    ..Soluble CXCL4, in turn, inhibits integrin-dependent endothelial cell adhesion and migration. As a whole, our study identifies integrins as novel receptors for CXCL4 that may contribute to its antiangiogenic effect...

Research Grants3

  1. TAP20, NOVEL INTEGRIN MODULATING PROTEIN
    Shaoqing Tang; Fiscal Year: 2001
    ..We anticipate that these studies should provide data that will be useful in designing new strategic for pharmacologic intervention in ischemic vascular disease and cancer. ..
  2. CELL ADHESION MOLECULES OF MAMMALIAN FERTILIZATION
    Janice Evans; Fiscal Year: 2008
    ..This research also will also address fundamental questions in cell adhesion biology by examining this interesting, biologically relevant cell-cell interaction event. ..
  3. Cytokines and angiotensin II-induced hypertension
    R Webb; Fiscal Year: 2008
    ..Biostatistical support and scientific management will be coordinated through the Administrative Unit. From these integrated projects, a better understanding of the factors contributing to hypertension will emerge. ..