Gene Symbol: ITGA8
Description: integrin subunit alpha 8
Alias: integrin alpha-8, integrin, alpha 8
Species: human
Products:     ITGA8

Top Publications

  1. Denda S, Reichardt L, Muller U. Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis. Mol Biol Cell. 1998;9:1425-35 pubmed
    ..Together with a recent report that anti-OPN antibodies disrupt kidney morphogenesis, our results suggest that interactions between OPN and integrin alpha8 beta1 may help regulate kidney development and other morphogenetic processes. ..
  2. Bieritz B, Spessotto P, Colombatti A, Jahn A, Prols F, Hartner A. Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation. Kidney Int. 2003;64:119-27 pubmed
    ..Thus, the data support the hypothesis that alpha8 integrin could play an important role for maintaining tissue integrity in the glomerulus during glomerular injury. ..
  3. Lu M, Munger J, Steadele M, Busald C, Tellier M, Schnapp L. Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. J Cell Sci. 2002;115:4641-8 pubmed
    ..These data strongly suggest that LAP-TGFbeta1 is a ligand of alpha8beta1 and interaction of alpha8beta1 with LAP-TGFbeta1 may influence cell behavior. ..
  4. Schnapp L, Hatch N, Ramos D, Klimanskaya I, Sheppard D, Pytela R. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995;270:23196-202 pubmed
  5. Schnapp L, Breuss J, Ramos D, Sheppard D, Pytela R. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. J Cell Sci. 1995;108 ( Pt 2):537-44 pubmed
    ..These results suggest that in adult mammalian tissues, alpha 8 is predominantly expressed in smooth muscle and smooth muscle-like contractile cells. ..
  6. Varnum Finney B, Venstrom K, Muller U, Kypta R, Backus C, Chiquet M, et al. The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C. Neuron. 1995;14:1213-22 pubmed
    ..Antibodies specific for each subunit of the integrin alpha 8 beta 1 are used to demonstrate that alpha 8 beta 1 mediates neurite outgrowth of embryonic sensory and motor ..
  7. Farias E, Lu M, Li X, Schnapp L. Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway. Biochem Biophys Res Commun. 2005;329:305-11 pubmed
    ..Therefore, alpha8-mediated survival appears to be mediated by the PI3 kinase pathway. Survival of alpha8-expressing myofibroblasts may contribute to persistent fibrosis following injury. ..
  8. Li H, Lu H. Transcriptome analyses identify key genes and potential mechanisms in a rat model of osteoarthritis. J Orthop Surg Res. 2018;13:319 pubmed publisher
    ..Two comparison cohorts shared 79 intersection genes, and of these, Ccl2, Col4a1, Col1a1, Aldh1a3, and Itga8 were defined as the hub genes...
  9. Lill C, Roehr J, McQueen M, Kavvoura F, Bagade S, Schjeide B, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 2012;8:e1002548 pubmed publisher
    ..In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P  =  1.3 × 10(-8))...

More Information


  1. Song J, Wu S, Xia X, Wang Y, Fan Y, Yang Z. Cell adhesion-related gene somatic mutations are enriched in aggressive papillary thyroid microcarcinomas. J Transl Med. 2018;16:269 pubmed publisher
    ..004). Nonsynonymous mutations of 13 genes (MUC5B, TNN, SSPO, PPFIA1, PCDHGA2, ITGA8, ITGA4, DCHS1, CRNN, ROCK1, RELN, LAMC2, and AEBP1) were involved in cell adhesion, and these were only present in ..
  2. Ihermann Hella A, Hirashima T, Kupari J, Kurtzeborn K, Li H, Kwon H, et al. Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation. Stem Cell Reports. 2018;11:912-928 pubmed publisher
    ..MAPK/ERK activity regulates niche organization and communication with extracellular matrix through PAX2 and ITGA8, and is needed for CITED1 expression denoting undifferentiated status...
  3. Li B, Qiao L, An L, Wang W, Liu J, Ren Y, et al. Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition. BMC Genomics. 2018;19:338 pubmed publisher
    ..In STH, genes such as LAMB3, RELN, TNXB, and ITGA8, were identified to be up regulated and LAMB4 was observed to be down regulated...
  4. Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse. Reprod Sci. 2016;23:931-43 pubmed publisher
    ..multiple matrix metalloproteinases (MMP3, MMP7, MMP10, MMP12, MMP13, and MMP14), integrins (ITGA1, ITGA4, ITGA6, ITGA8, ITGB1, ITGB2, and ITGB3), and cell adhesion molecules as compared to control-HVCs...
  5. Abouhajer F, El Ashram S, Karama M, Huang S, Liu J. An ex vivo ruminal ovine model to study the immediate immune response in the context of bacterial lipopolysaccharide. Funct Integr Genomics. 2018;18:277-285 pubmed publisher
    ..necrosis factor (TNF), interlukin (IL)-1 beta(b), IL-6, IL-8, IL-17B, IL-19, MMP-1, MMP-3, and integrin alpha 2 (ITGA8, 9)...
  6. Wu H, Chen C, Chen Y, Fung H, Chang K, Wu Y. DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2018;64:158.e1-158.e6 pubmed publisher
    ..rs1555399), glycoprotein nonmetastatic melanoma protein B (GPNMB rs199347), and integrin subunit alpha 8 (ITGA8 rs7077361)...
  7. Marek I, Canu M, Cordasic N, Rauh M, Volkert G, Fahlbusch F, et al. Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8. Biol Sex Differ. 2017;8:19 pubmed publisher well as marked renal injury in Apoe-/- mice deficient in the mesenchymal integrin chain Itga8 (Itga8-/-)...
  8. Talbot J, Nichols J, Yan Y, Leonard I, Bremiller R, Amacher S, et al. Pharyngeal morphogenesis requires fras1-itga8-dependent epithelial-mesenchymal interaction. Dev Biol. 2016;416:136-148 pubmed publisher
    Both Fras1 and Itga8 connect mesenchymal cells to epithelia by way of an extracellular 'Fraser protein complex' that functions in signaling and adhesion; these proteins are vital to the development of several vertebrate organs...
  9. Gao Y, Wang D, Wang H, Guan J, Lan L, Wu Z, et al. [Cinical and genetic characteristics of familial Meniere's disease: three families report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;50:915-24 pubmed
    ..2057G>A in EGFLAM and c. 1961C>T in ITGA8. Meniere's disease has some genetic and familial aggregation in Chinese population, but its complex genetic ..
  10. Marek I, Lichtneger T, Cordasic N, Hilgers K, Volkert G, Fahlbusch F, et al. Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11:e0150471 pubmed publisher
    The α8 integrin (Itga8) chain contributes to the regulation of cell proliferation and apoptosis in renal glomerular cells...
  11. Mizuno K, Nakane A, Nishio H, Moritoki Y, Kamisawa H, Kurokawa S, et al. Involvement of the bone morphogenic protein/SMAD signaling pathway in the etiology of congenital anomalies of the kidney and urinary tract accompanied by cryptorchidism. BMC Urol. 2017;17:112 pubmed publisher
    ..Of these, eight genes (i.e., SMAD4, ITGA8, GRIP1, FREM1, FREM2, TNXB, BMP8B, and SALL1) carried a single amino acid substitution that was common to all ..
  12. Ljubimov A, Saghizadeh M, Pytela R, Sheppard D, Kenney M. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. J Histochem Cytochem. 2001;49:1341-50 pubmed
    ..The interaction of tenascin-C with these integrins may contribute to the fibrotic process that occurs in PBK/ABK corneas. ..
  13. Humbert C, Silbermann F, Morar B, Parisot M, Zarhrate M, Masson C, et al. Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. Am J Hum Genet. 2014;94:288-94 pubmed publisher
    ..several fetuses with bilateral renal agenesis, we identified recessive mutations in the integrin ?8-encoding gene ITGA8 in two families. Itga8 homozygous knockout in mice is known to result in absence of kidney development...
  14. Ni R, Shen X, Wu H, Zhu W, Ni J, Huang Z, et al. [Expression and significance of integrins subunits in laryngeal squamous cell carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;24:686-9 pubmed
  15. Goodman L, Zallocchi M. Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells. J Cell Sci. 2017;130:3698-3712 pubmed publisher
    ..Here, we describe the existence of an integrin α8 (Itga8) and protocadherin-15a (Pcdh15a) ciliary complex in neuromast hair cells in a zebrafish model...
  16. Kohl S, Hwang D, Dworschak G, Hilger A, Saisawat P, Vivante A, et al. Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract. J Am Soc Nephrol. 2014;25:1917-22 pubmed publisher
    ..In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme...
  17. Supriyanto I, Watanabe Y, Mouri K, Shiroiwa K, Ratta Apha W, Yoshida M, et al. A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:347-52 pubmed publisher
    ..Genotypic and allelic distributions of rs2298033 in the ITGA8 gene between the schizophrenia and control groups were significantly different in the first batch (p=0.005 and 0...
  18. Kitchen C, Cowan S, Long X, Miano J. Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle. Gene. 2013;513:82-9 pubmed publisher
    ..Here, we analyzed the expression and promoter of a highly restricted integrin gene, Itga8. RNase protection and quantitative RT-PCR showed Itga8 to be expressed most abundantly in vascular smooth muscle ..
  19. Simón Sánchez J, Schulte C, Bras J, Sharma M, Gibbs J, Berg D, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009;41:1308-12 pubmed publisher
    ..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease. ..
  20. Sato Y, Uemura T, Morimitsu K, Sato Nishiuchi R, Manabe R, Takagi J, et al. Molecular basis of the recognition of nephronectin by integrin alpha8beta1. J Biol Chem. 2009;284:14524-36 pubmed publisher
  21. Lu X, Wan F, Zhang H, Shi G, Ye D. ITGA2B and ITGA8 are predictive of prognosis in clear cell renal cell carcinoma patients. Tumour Biol. 2016;37:253-62 pubmed publisher
    ..232, 95 % CI 1.097 to 1.383) and ITGA8 (HR = 0.804, 95 % CI 0.696 to 0.930) were shown predictive of ccRCC prognosis...
  22. Valerius M, Patterson L, Feng Y, Potter S. Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. Proc Natl Acad Sci U S A. 2002;99:8090-5 pubmed
    ..This work suggests that the Integrin alpha8 gene may be a major effector of Hoxa 11/Hoxd 11 function in the developing kidney. ..
  23. Benoit Y, Larrivée J, Groulx J, Stankova J, Vachon P, Beaulieu J. Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells. Biochem Biophys Res Commun. 2010;399:434-9 pubmed publisher
    ..Consequently, alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal HIECs, whereas its loss contributes to the illicit acquisition of anoikis resistance. ..
  24. Ashton K, Reichelt M, Mustafa S, Teng B, Ledent C, Delbridge L, et al. Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium. Purinergic Signal. 2017;13:27-49 pubmed publisher
    ..101) and Cxcl1 (+89) and the most repressed are Car3 (-38); Adipoq (-17); Atgrl1/Aplnr (-14); H19 (-11) and Itga8 (-8)...
  25. Zeltner R, Hilgers K, Schmieder R, Porst M, Schulze B, Hartner A. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin Pract. 2008;108:c169-75 pubmed publisher
    ..We investigated whether the -414 T/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD...
  26. Benoit Y, Lussier C, Ducharme P, Sivret S, Schnapp L, Basora N, et al. Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism. Biol Cell. 2009;101:695-708 pubmed publisher
    ..These results suggest an important role for this integrin in intestinal crypt cell homoeostasis. ..
  27. Littlewood Evans A, Muller U. Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000;24:424-8 pubmed
    ..In mice homozygous for a targeted mutation of Itga8 (encoding the alphabeta8 subunit), this co-localization is perturbed and hair cells in the utricle, a vestibular ..
  28. Scherberich A, Tucker R, Degen M, Brown Luedi M, Andres A, Chiquet Ehrismann R. Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. Oncogene. 2005;24:1525-32 pubmed
    ..Our results show that tenascin-W may be a useful diagnostic marker for breast malignancies, and that the induction of tenascin-W in the tumor stroma may contribute to the invasive behavior of tumor cells. ..
  29. Ekwa Ekoka C, Diaz G, Carlson C, Hasegawa T, Samudrala R, Lim K, et al. Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). Matrix Biol. 2004;23:487-96 pubmed
    ..Identification of the sequence variation will allow genetic association studies of alpha8 in kidney and lung disease. ..
  30. Brandenberger R, Schmidt A, Linton J, Wang D, Backus C, Denda S, et al. Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. J Cell Biol. 2001;154:447-58 pubmed
    ..The approaches used here should be generally useful for characterizing the interactions of novel extracellular matrix proteins identified through genomic sequencing projects. ..
  31. Hartner A, Schocklmann H, Prols F, Muller U, Sterzel R. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. Kidney Int. 1999;56:1468-80 pubmed
    ..However, in view of its abundance in the mesangium, alpha8beta1 integrin could be an important MC receptor of matrix ligands and may play a role in the embryology, physiology, and pathophysiology of the glomerular capillary tuft. ..