ITGA6

Summary

Gene Symbol: ITGA6
Description: integrin subunit alpha 6
Alias: CD49f, ITGA6B, VLA-6, integrin alpha-6, CD49 antigen-like family member F, integrin alpha6B, integrin, alpha 6
Species: human
Products:     ITGA6

Top Publications

  1. Tani T, Mercurio A. PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. J Biol Chem. 2001;276:36535-42 pubmed
    ..The binding site in alpha(6)B defines a new subclass of type I PDZ interaction site, characterized by a non-aliphatic residue at position 0. ..
  2. Davis T, Rabinovitz I, Futscher B, Schnolzer M, Burger F, Liu Y, et al. Identification of a novel structural variant of the alpha 6 integrin. J Biol Chem. 2001;276:26099-106 pubmed
    ..A novel form of the alpha(6) integrin exists on cell surfaces that contains a dramatically altered extracellular domain. ..
  3. Yu K, Yang S, Jung J, Kim H, Ko K, Han D, et al. CD49f enhances multipotency and maintains stemness through the direct regulation of OCT4 and SOX2. Stem Cells. 2012;30:876-87 pubmed publisher
    b>CD49f (integrin subunit ?6) regulates signaling pathways in a variety of cellular activities. However, the role of CD49f in regulating the differentiation and pluripotency of stem cells has not been fully investigated...
  4. Yang X, Richardson A, Torres Arzayus M, Zhou P, Sharma C, Kazarov A, et al. CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res. 2008;68:3204-13 pubmed publisher
  5. Hemler M, Crouse C, Sonnenberg A. Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. J Biol Chem. 1989;264:6529-35 pubmed
    ..The beta 4 subunit may be of major importance because (i) it is highly abundant on the surface of colon carcinoma cell lines, and (ii) it is highly immunogenic relative to other surface proteins. ..
  6. Wang Y, Shenouda S, Baranwal S, Rathinam R, Jain P, Bao L, et al. Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis. Mol Cancer. 2011;10:84 pubmed publisher
    ..The modulation of integrins reduces cdc25 A, another possible mechanism for downregulation of CDK2. Taken together we demonstrate a link between integrins and the chk1-cdc25-cyclin E/CDK2-Rb pathway. ..
  7. Pawar S, Demetriou M, Nagle R, Bowden G, Cress A. Integrin alpha6 cleavage: a novel modification to modulate cell migration. Exp Cell Res. 2007;313:1080-9 pubmed
    ..These data taken together suggest that the uPA-mediated cell surface cleavage of the alpha6 integrin extracellular domain is involved in tumor cell invasion and migration on laminin. ..
  8. Fukamachi H, Seol H, Shimada S, Funasaka C, Baba K, Kim J, et al. CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors. PLoS ONE. 2013;8:e72438 pubmed publisher
    ..We thus searched for another marker for gastric TICs, and found that CD49f(high) cells from newly-dissected gastric cancers formed tumors with histological features of parental ones while ..
  9. Geerts D, Fontao L, Nievers M, Schaapveld R, Purkis P, Wheeler G, et al. Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol. 1999;147:417-34 pubmed

More Information

Publications81

  1. Haraguchi N, Ishii H, Mimori K, Ohta K, Uemura M, Nishimura J, et al. CD49f-positive cell population efficiently enriches colon cancer-initiating cells. Int J Oncol. 2013;43:425-30 pubmed publisher
    ..The rates of change in CD44, CD133, CD166, CD24, CD49f and CXCR4 expression during sodium butyrate (NaBT)-induced cell differentiation were assessed in HT29 and Caco2 ..
  2. Dutta U, Shaw L. A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression. Cancer Res. 2008;68:8779-87 pubmed publisher
    ..Collectively, our results identify Y1494 as a major regulatory site for signaling from the alpha6beta4 integrin to promote tumor development and progression. ..
  3. Hogervorst F, Admiraal L, Niessen C, Kuikman I, Janssen H, Daams H, et al. Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit. J Cell Biol. 1993;121:179-91 pubmed
    ..There are also two variants of the integrin alpha 3 subunit with different cytoplasmic domains, but in the cell lines examined only alpha 3A could be demonstrated by RT-PCR.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  4. Amici S, Dunn W, Murphy A, Adams N, Gale N, Valenzuela D, et al. Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. J Neurosci. 2006;26:1179-89 pubmed
    ..Together, these data indicate that PMP22 is a binding partner in the integrin/laminin complex and is involved in mediating the interaction of SCs with the extracellular environment. ..
  5. Kawano S, Mizutani K, Miyata M, Ikeda W, Takai Y. Interaction of integrin alpha(6)beta(4) with ErbB3 and implication in heregulin-induced ErbB3/ErbB2-mediated DNA synthesis. Genes Cells. 2010;15:995-1001 pubmed publisher
    ..Here we show that integrin alpha(6)beta(4) interacts with ErbB3 but not with ErbB1, ErbB2 or ErbB4, and enhances the heregulin-induced, ErbB3/ErbB2 heterodimer-mediated DNA synthesis, but not cell motility, in A549 cells. ..
  6. Berditchevski F, Chang S, Bodorova J, Hemler M. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem. 1997;272:29174-80 pubmed
    ..Importantly, EMMPRIN-alpha3beta1 complexes appear not to contain TM4SF proteins, suggesting that they are distinct from TM4SF protein-alpha3beta1 complexes. ..
  7. Cariati M, Naderi A, Brown J, Smalley M, Pinder S, Caldas C, et al. Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line. Int J Cancer. 2008;122:298-304 pubmed
    ..Alpha-6 integrin proves to be required for the growth and survival of these cells, as the knockdown of ITGA6 causes mammosphere-derived cells to lose their ability to grow as mammospheres and abrogates their tumourigenicity ..
  8. Yamamoto H, Masters J, Dasgupta P, Chandra A, Popert R, Freeman A, et al. CD49f is an efficient marker of monolayer- and spheroid colony-forming cells of the benign and malignant human prostate. PLoS ONE. 2012;7:e46979 pubmed publisher
    ..Cell membrane protein markers, CD49f, CD133 and CD44, have been shown to identify putative prostate stem cells, but a lack of consensus exists with ..
  9. Davis T, Buerger F, Cress A. Differential regulation of a novel variant of the alpha(6) integrin, alpha(6p). Cell Growth Differ. 2002;13:107-13 pubmed
    ..These data suggest that the production of the alpha(6p) variant is distinct from alpha(6) integrin and may involve a post-translational processing event at the cell surface. ..
  10. Mannion B, Berditchevski F, Kraeft S, Chen L, Hemler M. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol. 1996;157:2039-47 pubmed
    ..Thus, CD81 and other transmembrane-4 superfamily members may participate in functionally relevant interactions with alpha 4 beta 1 and other integrins. ..
  11. Hopkinson S, Jones J. The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome. Mol Biol Cell. 2000;11:277-86 pubmed
    ..These data provide new insight into those interactions of the molecules of the hemidesmosome that are necessary for its function in integrating epithelial and connective tissue types. ..
  12. Vieira A, Ricardo S, Ablett M, Dionísio M, Mendes N, Albergaria A, et al. P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer. Stem Cells. 2012;30:854-64 pubmed publisher
    ..tumors, we showed that P-cadherin was directly associated with the expression of the breast stem markers CD44, CD49f, and aldehyde dehydrogenase 1 in the basal subtype...
  13. Sawai H, Funahashi H, Yamamoto M, Okada Y, Hayakawa T, Tanaka M, et al. Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer. Oncology. 2003;65:167-73 pubmed
    ..Our results indicated that alpha(6)beta(1)-integrin and IL-1RI expression may play important roles in metastasis formation. ..
  14. Aho S, Uitto J. Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes. Biochem Biophys Res Commun. 1998;243:694-9 pubmed
  15. Hogervorst F, Kuikman I, van Kessel A, Sonnenberg A. Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. Eur J Biochem. 1991;199:425-33 pubmed
    ..The genes for alpha 6 and beta 4, the alternative beta subunit with which alpha 6 combines on certain epithelial cells, were mapped to chromosome 2 and 17q11-qter, respectively. ..
  16. Berditchevski F, Bazzoni G, Hemler M. Specific association of CD63 with the VLA-3 and VLA-6 integrins. J Biol Chem. 1995;270:17784-90 pubmed
    ..Knowledge of these specific CD63-alpha 3 beta 1 and CD63-alpha 6 beta 1 biochemical associations should lead to critical insights into the specialized functions of alpha 3 beta 1, alpha 6 beta 1, and CD63. ..
  17. Dydensborg A, Teller I, Basora N, Groulx J, Auclair J, Francoeur C, et al. Differential expression of the integrins alpha6Abeta4 and alpha6Bbeta4 along the crypt-villus axis in the human small intestine. Histochem Cell Biol. 2009;131:531-6 pubmed publisher
    ..This suggests that differential expression of the alpha6 subunits is involved in the intestinal epithelial cell renewal process. Further studies will be needed to substantiate this hypothesis. ..
  18. Pulkkinen L, Kimonis V, Xu Y, Spanou E, McLean W, Uitto J. Homozygous alpha6 integrin mutation in junctional epidermolysis bullosa with congenital duodenal atresia. Hum Mol Genet. 1997;6:669-74 pubmed
    ..In this study we demonstrate, for the first time, a homozygous mutation in the alpha6 integrin gene (ITGA6) in a family with three affected individuals...
  19. Schaapveld R, Borradori L, Geerts D, van Leusden M, Kuikman I, Nievers M, et al. Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. J Cell Biol. 1998;142:271-84 pubmed
    ..Unfolding of the cytoplasmic domain may be part of a mechanism by which the interaction of beta4 with other hemidesmosomal components, e.g., BP180, is regulated. ..
  20. Hogervorst F, Kuikman I, Noteboom E, Sonnenberg A. The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor. J Biol Chem. 1993;268:18427-30 pubmed
  21. Fu B, Wu Z, Qin J. Effects of integrin ?6?1 on migration of hepatocellular carcinoma cells. Mol Biol Rep. 2011;38:3271-6 pubmed publisher
    ..But the ?6 subunit has minimal effect on pseudopod formation in response to type IV collagen. Therefore, the integrin ?6?1-mediated cell migration is, at least in part, through the regulation on the cell adhesion step. ..
  22. Tamura R, Rozzo C, Starr L, Chambers J, Reichardt L, Cooper H, et al. Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. J Cell Biol. 1990;111:1593-604 pubmed
    The integrin alpha 6 beta 4 is a heterodimer predominantly expressed by epithelia. While no definite receptor function has yet been assigned to it, this integrin may mediate adhesive and/or migratory functions of epithelial cells...
  23. Dydensborg A, Teller I, Groulx J, Basora N, Paré F, Herring E, et al. Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity. BMC Cancer. 2009;9:223 pubmed publisher
    ..Taken together, these findings point out the importance of integrin variant expression in colon cancer cell biology. ..
  24. Yang X, Dutta U, Shaw L. SHP2 mediates the localized activation of Fyn downstream of the ?6?4 integrin to promote carcinoma invasion. Mol Cell Biol. 2010;30:5306-17 pubmed publisher
    ..Of significance for tumor progression, phosphorylation of Y580-SHP2 and SFK activation are increased in orthotopic human breast tumors that express ?6?4 and activation of this pathway is dependent upon Y1494. ..
  25. Lee R, Seo M, Pulin A, Gregory C, Ylostalo J, Prockop D. The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood. 2009;113:816-26 pubmed publisher
    ..that were selectively expressed in the early progenitors: podocalyxin-like protein (PODXL), alpha6-integrin (CD49f), alpha4-integrin (CD49d), c-Met, CXCR4, and CX3CR1...
  26. Lipscomb E, Mercurio A. Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev. 2005;24:413-23 pubmed
  27. Mariotti A, Kedeshian P, Dans M, Curatola A, Gagnoux Palacios L, Giancotti F. EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol. 2001;155:447-58 pubmed
    ..These results suggest that disruption of hemidesmosomes mediated by Fyn is a prerequisite for normal keratinocyte migration and squamous carcinoma invasion...
  28. Ruzzi L, Gagnoux Palacios L, Pinola M, Belli S, Meneguzzi G, D Alessio M, et al. A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia. J Clin Invest. 1997;99:2826-31 pubmed
  29. Mainiero F, Pepe A, Wary K, Spinardi L, Mohammadi M, Schlessinger J, et al. Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 1995;14:4470-81 pubmed
    We have examined the mechanism of signal transduction by the hemidesmosomal integrin alpha 6 beta 4, a laminin receptor involved in morphogenesis and tumor progression...
  30. Chung J, Bachelder R, Lipscomb E, Shaw L, Mercurio A. Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J Cell Biol. 2002;158:165-74 pubmed
    ..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression. ..
  31. Wilhelmsen K, Litjens S, Sonnenberg A. Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol. 2006;26:2877-86 pubmed
  32. Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, et al. Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains. FEBS Lett. 1999;445:351-5 pubmed
    ..The conserved membrane proximal region of the alpha3A chain was identified as the binding site for all four proteins. They, therefore, may be involved in the regulation of general functions of integrins. ..
  33. Lathia J, Gallagher J, Heddleston J, Wang J, Eyler C, Macswords J, et al. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell. 2010;6:421-32 pubmed publisher
    ..Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy...
  34. Marchio S, Soster M, Cardaci S, Muratore A, Bartolini A, Barone V, et al. A complex of ?6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. EMBO Mol Med. 2012;4:1156-75 pubmed publisher
    ..Consistently, we show that high amounts of coexpressed ?(6) integrin and E-cadherin in primary tumours represent a poor prognostic factor for patients with advanced CRC. ..
  35. Oikawa Y, Hansson J, Sasaki T, Rousselle P, Domogatskaya A, Rodin S, et al. Melanoma cells produce multiple laminin isoforms and strongly migrate on ?5 laminin(s) via several integrin receptors. Exp Cell Res. 2011;317:1119-33 pubmed publisher
  36. Kikkawa Y, Sanzen N, Fujiwara H, Sonnenberg A, Sekiguchi K. Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins. J Cell Sci. 2000;113 ( Pt 5):869-76 pubmed
    ..transfected with alpha 6 and beta 4 subunits were also capable of adhering to laminin-10/11, indicating that integrin alpha 6 beta 4 is another receptor for laminin-10/11...
  37. Wine R, Dial J, Tomer K, Borchers C. Identification of components of protein complexes using a fluorescent photo-cross-linker and mass spectrometry. Anal Chem. 2002;74:1939-45 pubmed
    ..The identification of integrin alpha6 precursor was confirmed by Western blot analysis and verifies the applicability of this novel approach for identifying proteins involved in protein complexes. ..
  38. Bonig H, Priestley G, Wohlfahrt M, Kiem H, Papayannopoulou T. Blockade of alpha6-integrin reveals diversity in homing patterns among human, baboon, and murine cells. Stem Cells Dev. 2009;18:839-44 pubmed publisher
    ..By contrast, despite high alpha6 integrin expression, no effect of alpha6 blockade on murine BM-HSPCs homing/engraftment was observed. ..
  39. Park H, Park J, Lee H, Kim S, Yun J, Kim M, et al. Integrins functioning in uterine endometrial stromal and epithelial cells in estrus. Reproduction. 2017;153:351-360 pubmed publisher
    ..Itga2, Itga5, Itga6, Itga9, Itgav, Itgb1, Itgb3 and Itgb5 in ES cells, and Itga2, Itga5, Itga6, Itga7, Itga9, Itgav, Itgb1, Itgb3, ..
  40. Gulubova M. Collagen type IV, laminin, alpha-smooth muscle actin (alphaSMA), alpha1 and alpha6 integrins expression in the liver with metastases from malignant gastrointestinal tumours. Clin Exp Metastasis. 2004;21:485-94 pubmed
  41. Ziober B, Vu M, Waleh N, Crawford J, Lin C, Kramer R. Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. J Biol Chem. 1993;268:26773-83 pubmed
  42. Song H, Zhang Y, Ding Y, Ji Q, Yang M, Fan S, et al. [Ex vivo Culture System of Single Human Hematopoietic Stem Cell Used to Screan the Small Molecular Compounds]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:845-51 pubmed publisher
    ..The results of multiparameter sorting of single cell (CD34+ CD38- CD45RA- CD90+ CD49f+) and ex vivo culture were consistent with the results of bulk cell culture...
  43. Henry G, Malewska A, Mauck R, Gahan J, Hutchinson R, Torrealba J, et al. Molecular pathogenesis of human prostate basal cell hyperplasia. Prostate. 2017;77:1344-1355 pubmed publisher
    ..These data provide insight into the plasticity of the human prostate epithelium and suggest a classification of basal cell hyperplasia as a metaplasia. ..
  44. Chen J, Nagle A, Wang Y, Boone D, Lee A. Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. J Biol Chem. 2018;293:3700-3709 pubmed publisher
    ..JUN and BCL2L1; holo-InsR down-regulated but HybR up-regulated HK2; and HybR specifically up-regulated FHL2, ITGA6, and PCK2...
  45. Sterk L, Geuijen C, Van Den Berg J, Claessen N, Weening J, Sonnenberg A. Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo. J Cell Sci. 2002;115:1161-73 pubmed
    ..These results suggest that the interactions between CD151 and laminin-binding integrins are subject to cell-type-specific regulation. ..
  46. Kim S, Cheng Y, Hsu F, Jin T, Kader A, Zheng S, et al. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. Prostate. 2010;70:1729-38 pubmed publisher
    ..These SNPs explain a considerable proportion of genetic variance, however, the majority of genetic variance has yet to be explained. ..
  47. Zhang L, Koivisto L, Heino J, Uitto V. Bacterial heat shock protein 60 may increase epithelial cell migration through activation of MAP kinases and inhibition of alpha6beta4 integrin expression. Biochem Biophys Res Commun. 2004;319:1088-95 pubmed
    ..These results suggest that exogenous hsp60 released from bacteria or inflammatory cells may promote epithelial cell migration through activation of EGFR and MAP kinases, and inhibition of alpha6beta4 integrin expression. ..
  48. Acosta K, Lorenzini Campos M, Etcheverry S, Zapata P. ?6?4 Integrin Genetic Variations (A380T and R1281W) and Breast Cancer Risk in an Argentinian Population. Int J Mol Sci. 2016;17: pubmed
    ..The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature. ..
  49. Li B, Zhuang M, Wu C, Niu B, Zhang Z, Li X, et al. Bovine male germline stem-like cells cultured in serum- and feeder-free medium. Cytotechnology. 2016;68:2145-57 pubmed publisher
    ..morphology, and expressed specific surface markers of both pluripotent ES cells and mGSCs, including SSEA-1, CD49f, C-MYC, PLZF, GFRα1, LIN28, NANOG, Oct4 and SOX2 in commercial human ESCs medium PeproGrow-hESC + BIO (6-..
  50. Brendle A, Lei H, Brandt A, Johansson R, Enquist K, Henriksson R, et al. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis. 2008;29:1394-9 pubmed publisher
    ..the effect of single-nucleotide polymorphisms (SNPs) in predicted miRNA target sites of six integrin genes (ITGA3, ITGA6, ITGAv, ITGB3, ITGB4 and ITGB5) on breast cancer (BC) risk and clinical outcome...
  51. Shlush E, Maghen L, Swanson S, Kenigsberg S, Moskovtsev S, Barretto T, et al. In vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells. Stem Cell Res Ther. 2017;8:37 pubmed publisher
    ..known to regulate spermatogenesis (LIF, GDNF, BMP4, bFGF) and 10-20% of HUCPVCs co-expressed SSEA4, CD9, CD90, and CD49f. We hypothesize that the paracrine properties and cellular heterogeneity of HUCPVCs may explain their dual ..
  52. Bonardi F, Fusetti F, Deelen P, van Gosliga D, Vellenga E, Schuringa J. A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers. Mol Cell Proteomics. 2013;12:626-37 pubmed publisher
    ..such as CD47, CD44, CD135, CD96, and ITGA5, but also novel ones like CD82, CD97, CD99, PTH2R, ESAM, MET, and ITGA6. Further validation by flow cytometry and functional studies indicated that long-term self-renewing leukemic stem ..
  53. Jeong Y, Rhee H, Martin S, Klass D, Lin Y, Nguyen L, et al. Identification and genetic manipulation of human and mouse oesophageal stem cells. Gut. 2016;65:1077-86 pubmed publisher
    ..Sphere-forming cells were 10-15-fold enriched among human CD49f(hi)CD24(low) cells and murine CD49f(+)CD24(low)CD71(low) cells compared with the most differentiated cells...
  54. DiGiuseppe J, Fuller S, Borowitz M. Overexpression of CD49f in precursor B-cell acute lymphoblastic leukemia: potential usefulness in minimal residual disease detection. Cytometry B Clin Cytom. 2009;76:150-5 pubmed publisher
    ..The gene encoding CD49f (integrin alpha-6) is one of several whose overexpression in pB-ALL at diagnosis has been associated with the ..
  55. Harryman W, Gard J, Pond K, Simpson S, Heppner L, Hernandez Cortes D, et al. Targeting the Cohesive Cluster Phenotype in Chordoma via ?1 Integrin Increases Ionizing Radiation Efficacy. Neoplasia. 2017;19:919-927 pubmed publisher
    ..U-CH1 cells expressed brachyury, YAP, and laminin adhesion receptors (CD49c, CD49f, CD44), and approximately 15% to 20% of U-CH1 cells featured an ?6 integrin-dependent (CD49f) cohesive cluster ..
  56. Eeles R, Kote Jarai Z, Al Olama A, Giles G, Guy M, Severi G, et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009;41:1116-21 pubmed publisher
    ..In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)). ..
  57. Soung Y, Korneeva N, Kim T, Chung J. The role of c-Src in integrin (?6?4) dependent translational control. BMC Cell Biol. 2013;14:49 pubmed publisher
    ..Overall, our studies suggest that integrin ?4 and c-Src activation is important early signaling events to lead mTOR activation and cap-dependent translation of VEGF. ..
  58. Ieguchi K, Fujita M, Ma Z, Davari P, Taniguchi Y, Sekiguchi K, et al. Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling. J Biol Chem. 2010;285:31388-98 pubmed publisher
    ..These results suggest that direct NRG1-integrin interaction mediates integrin-ErbB cross-talk and that ?6?4 plays a major role in NRG-ErbB signaling in these cancer cells. ..
  59. Dall G, Vieusseux J, Korach K, Arao Y, Hewitt S, Hamilton K, et al. SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment. Stem Cell Reports. 2017;8:417-431 pubmed publisher
    ..we sought to determine if SCA-1 could define an ER?+ subset of EpCAM+/CD24+/CD49fhi MaSCs...
  60. Linhares M, Affonso R, Viana L, Silva S, Denadai M, de Toledo S, et al. Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer: Models for Global and Disease-Free Survival. PLoS ONE. 2015;10:e0144333 pubmed publisher
    ..001), ITGA3 (p = 0.002), ITGA6 (p = 0.001), SPARC (p = 0.036), MMP9 (p = 0.034), and MMP16 (p = 0.038) were observed...
  61. Lee H, Ji S, Park S, Choung H, Choi Y, Lee H, et al. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. J Biol Chem. 2015;290:14740-53 pubmed publisher
    ..We also propose that ODAM could be used as a biomarker of periodontitis and peri-implantitis. ..
  62. Klahan S, Wu M, Hsi E, Huang C, Hou M, Chang W. Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration. Biomed Res Int. 2014;2014:536591 pubmed publisher
    ..In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton...
  63. Landowski T, Gard J, Pond E, Pond G, Nagle R, Geffre C, et al. Targeting integrin α6 stimulates curative-type bone metastasis lesions in a xenograft model. Mol Cancer Ther. 2014;13:1558-66 pubmed publisher
    ..Recent studies have demonstrated a role for the α6 integrin (ITGA6/CD49f) in maintaining stem cell compartments within normal bone marrow and in residency of tumors metastatic to bone...
  64. Villa Diaz L, Kim J, Laperle A, Palecek S, Krebsbach P. Inhibition of Focal Adhesion Kinase Signaling by Integrin ?6?1 Supports Human Pluripotent Stem Cell Self-Renewal. Stem Cells. 2016;34:1753-64 pubmed publisher
    ..In conclusion, hPSCs promote the expression of integrin ?6?1, and nuclear localization and inactivation of FAK to supports stem cell self-renewal. Stem Cells 2016;34:1753-1764. ..
  65. Sudhakaran P, Viji R, Kiran M, Sameer Kumar V. Endothelial cell-laminin interaction: modulation of LDH expression involves alpha6beta4 integrin-FAK-p38MAPK pathway. Glycoconj J. 2009;26:697-704 pubmed publisher
    ..These results provide evidence for modulation of endothelial cell function relevant to angiogenesis by Ln through alpha(6)beta(4) integrin. ..
  66. Stampolidis P, Ullrich A, Iacobelli S. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, promotes oncogenic cellular events impeded by antibody intervention. Oncogene. 2015;34:39-52 pubmed publisher
    ..These novel findings reveal the mechanism of action of LGALS3BP during cellular adherence and warrant its further validation as a potential pharmacological target for anticancer therapies. ..
  67. Kligys K, Wu Y, Hopkinson S, Kaur S, Platanias L, Jones J. ?6?4 integrin, a master regulator of expression of integrins in human keratinocytes. J Biol Chem. 2012;287:17975-84 pubmed publisher
    ..Our data indicate that the ?6?4 integrin is a master regulator of transcription and translation of other integrin subunits and underscore its pivotal role in wound healing and cancer. ..
  68. Delwel G, Hogervorst F, Sonnenberg A. Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate. J Biol Chem. 1996;271:7293-6 pubmed
    ..However, inside/out signaling is affected. It appears that cleavage of alpha6 is required to generate the proper conformation in alpha6 that enables affinity modulation of the alpha6A-beta1 receptor by phorbol 12-myristate 13-acetate. ..
  69. Mahimkar R, Visaya O, Pollock A, Lovett D. The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins. Biochem J. 2005;385:461-8 pubmed
    ..It is concluded that ADAM9 is a polyvalent ligand, through its disintegrin domain, for multiple renal integrins of the beta1 class...
  70. Sonnenberg A, Linders C, Modderman P, Damsky C, Aumailley M, Timpl R. Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. J Cell Biol. 1990;110:2145-55 pubmed
    ..Cell adhesion to E8 was blocked completed by integrin alpha 6 or beta 1 antibodies. The alpha 6-specific antibody did not inhibit cell adhesion to E3 or P1...
  71. Aksoy P, Abban C, Kiyashka E, Qiang W, Meneses P. HPV16 infection of HaCaTs is dependent on ?4 integrin, and ?6 integrin processing. Virology. 2014;449:45-52 pubmed publisher
    ..We propose that the ?6?4 complex is necessary for the formation of an endocytic complex that results in the signaling transduction events necessary for initial endocytosis. ..
  72. Kajiji S, Tamura R, Quaranta V. A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. EMBO J. 1989;8:673-80 pubmed
    ..Therefore, the epithelial integrin may represent the prototype of a fourth integrin family, because it contains a structurally distinct beta chain. The designation alpha E beta 4 is proposed for this novel human integrin. ..