Research Topics

Genomes and Genes

ITGA2

Summary

Gene Symbol: ITGA2
Description: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Summary: This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. [provided by RefSeq]
Alias: BR, CD49B, GPIa, VLA-2, VLAA2, integrin alpha 2, platelet antigen Br, platelet glycoprotein GPIa, platelet glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit
Species: human
Products:     ITGA2 antibody    ITGA2 cDNA    ITGA2 protein    ITGA2 siRNA    ITGA2 other

Webpages

  1. search in swiss-prot for: laminin
    embryology.med.unsw.edu.au/DNA/swisspr/laminin.htm
  2. collagen receptor integrins - research groups
    research.utu.fi/receptor/projects/heino/heino.html
  3. professor michael berndt
    www.med.monash.edu.au/biochem/staff/berndt.html
  4. specialty laboratories ::: we help doctors help patients
    www.specialtylabs.com/tests/details.asp?id=S50896
  5. collagen receptors
    www.scripps.edu/mem/eht/kunicki/index.html
  6. ecat foundation - programme and cost 2009
    www.ecat.nl/content/view/45/73/index.html
  7. ecat foundation - programme and cost 2009
    www.ecat.nl/content/view/45/74/index.html
  8. collagen receptors
    www.scripps.edu/mem/eht/kunicki/aspresis.html

Research Grants

  1. The molecular pathogenesis of hookworm anemia
    Michael Cappello; Fiscal Year: 2005
  2. Gene Regulation And Function Of Basement Membranes
    Yoshihiko Yamada; Fiscal Year: 2006
  3. A novel platelet inhibitor from bloodfeeding hookworms
    Michael Cappello; Fiscal Year: 2003
  4. Transgenic Mouse Model for Echovirus Pathogenesis
    Vincent R Racaniello; Fiscal Year: 2004
  5. Regulation of beta1 integrin glycosylation by ras
    Susan L Bellis; Fiscal Year: 2008
  6. Signal Transduction in Atherosclerosis
    Garret A Fitzgerald; Fiscal Year: 2008
  7. Molecular Genetics of Integrin Collagen Receptors
    Thomas J Kunicki; Fiscal Year: 2007
  8. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas J Kunicki; Fiscal Year: 2004
  9. Regulation of beta1 integrin glycosylation by ras
    Susan L Bellis; Fiscal Year: 2007
  10. Biomarkers for Prostate and Bladder Cancer
    Alvin Y Liu; Fiscal Year: 2008

Publications

  1. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66
  2. Polymorphism of the glycoprotein Ia and IIIa in the group of women in childbirth does not correlate with an increased risk of developing thrombosis
    Lech Podciechowski
    Department of Fetal Maternal Medicine and Gynecology, Polish Mother s Health Research Insitute, Lodz, Poland
    Neuro Endocrinol Lett 26:789-94
  3. Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Jacksonville, Florida, USA
    Am J Cardiol 96:1095-9
  4. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion
    Martin Weger
    Department of Ophthalmology, Medical University Graz, Graz, Austria
    Ophthalmology 112:1910-5
  5. Microarray-based genotyping for blood groups: comparison of gene array and 5'-nuclease assay techniques with human platelet antigen as a model
    Peter Bugert
    Institute of Transfusion Medicine and Immunology, University of Heidelberg, Faculty of Clinical Medicine, Mannheim, Germany
    Transfusion 45:654-9
  6. HPA polymorphism in sub-Saharan African populations: Beninese, Cameroonians, Congolese, and Pygmies
    L Halle
    Institut National de la Transfusion Sanguine, Paris, France
    Tissue Antigens 65:295-8
  7. Multiple beta 1 integrins mediate enhancement of human airway smooth muscle cytokine secretion by fibronectin and type I collagen
    Qi Peng
    Department of Asthma, Allergy and Respiratory Science, The Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Hospital Campus, London, United Kingdom
    J Immunol 174:2258-64
  8. The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, TX 77030, USA
    Blood 105:1986-91
  9. Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation
    E M Kotzampasaki
    Department of Immunology and National Tissue Typing Center, General Hospital of Athens, Athens, Greece
    Transplant Proc 36:1735-8
  10. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin
    Gregory Bix
    Department of Pathology, Anatomy and Cell Biology, Rm 249 JAH, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    J Cell Biol 166:97-109

Scientific Experts

Detail Information

Webpages9

  1. search in swiss-prot for: laminin
    embryology.med.unsw.edu.au/DNA/swisspr/laminin.htm
  2. collagen receptor integrins - research groups
    research.utu.fi/receptor/projects/heino/heino.html
  3. professor michael berndt
    www.med.monash.edu.au/biochem/staff/berndt.html
  4. specialty laboratories ::: we help doctors help patients
    www.specialtylabs.com/tests/details.asp?id=S50896
  5. collagen receptors
    www.scripps.edu/mem/eht/kunicki/index.html
  6. ecat foundation - programme and cost 2009
    www.ecat.nl/content/view/45/73/index.html
  7. ecat foundation - programme and cost 2009
    www.ecat.nl/content/view/45/74/index.html
  8. collagen receptors
    www.scripps.edu/mem/eht/kunicki/aspresis.html

Research Grants26

  1. The molecular pathogenesis of hookworm anemia
    Michael Cappello; Fiscal Year: 2005
    ..platelet inhibitor blocks the function of two important platelet integrins, glycoprotein Jib/lila (GPIIb/IIIa) and GPIa/Iia, which mediate platelet binding to fibrinogen and collagen, respectively...
  2. Gene Regulation And Function Of Basement Membranes
    Yoshihiko Yamada; Fiscal Year: 2006
    ..Although the mechanisms of these phenotypes are not clear, our results suggest that perlecan plays important roles in cellular processes in various tissues in adults...
  3. A novel platelet inhibitor from bloodfeeding hookworms
    Michael Cappello; Fiscal Year: 2003
    ..protein is the first naturally occurring compound shown to block the binding of platelet integrins GPIIb/IIIa and GPIa/IIa, the cell surface receptors for fibrinogen and collagen, respectively...
  4. Transgenic Mouse Model for Echovirus Pathogenesis
    Vincent R Racaniello; Fiscal Year: 2004
    ..Establishment of a small animal model may yield information about echovirus pathogenesis that could stimulate development of echovirus vaccines or antiviral drugs...
  5. Regulation of beta1 integrin glycosylation by ras
    Susan L Bellis; Fiscal Year: 2008
    ..Our work suggests that ST6Gal I, and accordingly, integrin alpha 2-6 sialylation, are upregulated in tumor cell lines that have oncogenic ras, as well as in human colon tumors...
  6. Signal Transduction in Atherosclerosis
    Garret A Fitzgerald; Fiscal Year: 2008
    ..Factors which underlie the cell to cell heterogeneity of this interaction are likely to contribute to the focal nature of atherogenesis. Public Health Relevance: This Public Health Relevance is not available...
  7. Molecular Genetics of Integrin Collagen Receptors
    Thomas J Kunicki; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): The integrin alpha-1 gene (ITGA1) and alpha-2 gene (ITGA2) each encode a subunit that directs specificity for collagens...
  8. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas J Kunicki; Fiscal Year: 2004
    DESCRIPTION: (Investigator's abstract) Platelet GPVI and integrin alpha 2/beta 1 cooperate closely to mediate effective platelet adhesion to collagens and subsequent platelet procoagulant activity...
  9. Regulation of beta1 integrin glycosylation by ras
    Susan L Bellis; Fiscal Year: 2007
    ..Our work suggests that ST6Gal I, and accordingly, integrin alpha 2-6 sialylation, are upregulated in tumor cell lines that have oncogenic ras, as well as in human colon tumors...
  10. Biomarkers for Prostate and Bladder Cancer
    Alvin Y Liu; Fiscal Year: 2008
    ..The goal is to develop an assay for cancer associated protein markers that can be detected in voided urine for the diagnosis of prostate and bladder cancer. Public Health Relevance: This Public Health Relevance is not available...
  11. Dissection of cellular interactions with integrated functional genomics in comple
    Martin J Hessner; Fiscal Year: 2008
    ..This abstract is not available. Public Health Relevance: This Public Health Relevance is not available...
  12. Molecular Basis of Platelet Adhesion
    Miguel A Cruz; Fiscal Year: 2008
    ..It will provide molecular guidance for the generation of reagents to treat arterial thrombosis. Public Health Relevance: This Public Health Relevance is not available...
  13. MMP-7 and SNARE Cleavage in Neuroinflammation
    KATHERINE E CONANT; Fiscal Year: 2008
    ..Excess levels of select proteases may be considered as novel targets for neuro-protective drugs. Public Health Relevance: This Public Health Relevance is not available...
  14. CD Expression in Prostate Cancer
    Alvin Y Liu; Fiscal Year: 2004
    ..CD10 and CD13 are both peptidases and are likely involved in the processing of bioactive signaling peptides. Their absence might lead to the aberrant cellular differentiation and development of cancer...
  15. Urologic Epithelial Stem Cells
    Alvin Y Liu; Fiscal Year: 2004
    ..cell types can be identified; (2) to use flow cytometry to characterize and sort by CD expression (in particular, CD49b; CD49f, and CD71) progenitor cells, which are postulated to comprise a similar proportion in these and other ..
  16. Thrombin signaling and HIV dementia
    KATHERINE E CONANT; Fiscal Year: 2006
    ....
  17. MMPs in neural networking
    KATHERINE E CONANT; Fiscal Year: 2006
    ..We will also test the hypothesis that such effects are dependent on neuronal integrins. The results of our studies should improve our understanding of those CNS inflammatory diseases that are characterized by elevated levels of MMPs...
  18. Molecular Basis of Platelet Adhesion
    Miguel A Cruz; Fiscal Year: 2007
    ..It may also contribute to the development of an effective assay to detect the activity of the metalloprotease in plasma. It will provide molecular guidance for the generation of reagents to treat arterial thrombosis...
  19. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander P Reiner; Fiscal Year: 2006
    ....
  20. HIGH DENSITY MICROARRAYS WITH QUANTITATIVE QC/QA
    Martin J Hessner; Fiscal Year: 2006
    ..Our success will provide an accurate, flexible, lower cost alternative to commercial arrays for laboratories wishing to conduct gene expression studies...
  21. Exogenous Stressors and Birth Defects Risks
    Suzan L Carmichael; Fiscal Year: 2005
    ..This research will enhance scientific understanding of the causes of several common, costly, often deadly birth defects, which will undoubtedly have important implications for their risk assessment and prevention...
  22. MMPS IN HIV DEMENTIA: EFFECTS ON BBB STRUCTURE/FUNCTION
    KATHERINE E CONANT; Fiscal Year: 2003
    ..Also, the proposed studies will use both primary brain-derived HIV isolates, which differ from laboratory adapted strains, and normal human cells, which also differ significantly from those of rodent or tumor origin...
  23. HIV 1 PROTEINS AND DRUGS OF ABUSE AND METALLOPROTEASES
    KATHERINE E CONANT; Fiscal Year: 2003
    ..We will also examine the mechanisms by which these substances may affect MMP production, and identify clinically tolerable compounds which may inhibit such production...
  24. MMPs and Synaptic Injury with HIV/METH
    KATHERINE E CONANT; Fiscal Year: 2007
    ....
  25. Biomarkers for Prostate and Bladder Cancer
    Alvin Y Liu; Fiscal Year: 2007
    ..Urine samples will be obtained from cancer patients and age-matched volunteers. The goal is to develop an assay for cancer associated protein markers that can be detected in voided urine for the diagnosis of prostate and bladder cancer...
  26. MMPs and Synaptic Injury with HIV/METH
    KATHERINE E CONANT; Fiscal Year: 2008
    ..Public Health Relevance: This Public Health Relevance is not available...

Publications62

  1. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66
    ..The aim of this research was to evaluate the effect of genetic polymorphisms C807T and G1648A of platelet glycoprotein Ia (GPIa), on the risk for myocardial infarction (MI) and on the release of soluble CD40 ligand (sCD40L) ..
  2. Polymorphism of the glycoprotein Ia and IIIa in the group of women in childbirth does not correlate with an increased risk of developing thrombosis
    Lech Podciechowski
    Department of Fetal Maternal Medicine and Gynecology, Polish Mother s Health Research Insitute, Lodz, Poland
    Neuro Endocrinol Lett 26:789-94
    ..Probably presence of pro-thrombotic mutations of platelets glycoprotein in this group of patients does not represent the increased risk of thrombosis...
  3. Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene
    Dominick J Angiolillo
    Division of Cardiology, University of Florida, Jacksonville, Florida, USA
    Am J Cardiol 96:1095-9
    ..These findings may contribute to the increased ischemic risk observed in these patients...
  4. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion
    Martin Weger
    Department of Ophthalmology, Medical University Graz, Graz, Austria
    Ophthalmology 112:1910-5
    ..V Leiden), prothrombin 20210G>A, fibrinogen beta -455G> A, factor XII (FXII) 46C>T, and ITGA2 807C>T (platelet glycoprotein Ia [GPIa] 807C>T) and ITGB3 L59P (platelet GPIIIa PlA1/PlA2) polymorphisms...
  5. Microarray-based genotyping for blood groups: comparison of gene array and 5'-nuclease assay techniques with human platelet antigen as a model
    Peter Bugert
    Institute of Transfusion Medicine and Immunology, University of Heidelberg, Faculty of Clinical Medicine, Mannheim, Germany
    Transfusion 45:654-9
    ..CONCLUSION: The data presented here validate the use of microarray for large-scale SNP typing for clinically relevant blood group alloantigens...
  6. HPA polymorphism in sub-Saharan African populations: Beninese, Cameroonians, Congolese, and Pygmies
    L Halle
    Institut National de la Transfusion Sanguine, Paris, France
    Tissue Antigens 65:295-8
    ....
  7. Multiple beta 1 integrins mediate enhancement of human airway smooth muscle cytokine secretion by fibronectin and type I collagen
    Qi Peng
    Department of Asthma, Allergy and Respiratory Science, The Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Hospital Campus, London, United Kingdom
    J Immunol 174:2258-64
    ..Enhancement of cytokine release from ASM by these ECM components may contribute to airway wall inflammation and remodeling in asthma...
  8. The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain
    Miguel A Cruz
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1319, Houston, TX 77030, USA
    Blood 105:1986-91
    ..These results strongly suggest that the interaction of platelet GP Ib with VWF mediates the activation of alpha2beta1, increasing its affinity for collagen...
  9. Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation
    E M Kotzampasaki
    Department of Immunology and National Tissue Typing Center, General Hospital of Athens, Athens, Greece
    Transplant Proc 36:1735-8
    ..The HA-1H allele encodes histidine, whereas the HA-1R allele encodes arginine. The HPA-5b (Br(a)) allele encodes lysine, whereas the HPA-5a (Br(b)) encodes glutamic acid...
  10. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin
    Gregory Bix
    Department of Pathology, Anatomy and Cell Biology, Rm 249 JAH, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    J Cell Biol 166:97-109
    ....
  11. 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment
    Dominick J Angiolillo
    Cardiovascular Institute, San Carlos University Hospital, Madrid, Spain
    Blood Coagul Fibrinolysis 15:427-33
    ..The 807 C/T polymorphism of the GP Ia gene (ITGA2) has been associated with platelet GP Ia/IIa receptor expression, having T-allele carriers, increased receptor ..
  12. VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins
    Young Kwon Hong
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    FASEB J 18:1111-3
    ....
  13. The role of beta1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistance
    G E Morozevich
    Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia
    Biochemistry (Mosc) 71:489-95
    ..These data show that activation of beta1-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells...
  14. Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion
    Ophira Salomon
    Amalia Biron Research Institute of Thrombosis and Hemostasis Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood Coagul Fibrinolysis 17:485-8
    ..No relationship was found between the four platelet glycoprotein polymorphisms i.e. GPIa C807T, VNTR and Kozak of glycoprotein Ibalpha, the HPA-1 of glycoprotein IIIa and the occurrence of branch retinal ..
  15. Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study
    Neill J Turner
    UK Centre for Tissue Engineering, Manchester, United Kingdom
    Circulation 114:820-9
    ....
  16. [Association of the integrin gene polymorphisms with ischemic stroke and plasma lipid levels]
    Ye Sheng Wei
    The Affiliated Hospital of YouJiang Medical College for Nationalities, Baise, Guangxi, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:211-5
    OBJECTIVE: To study the association of integrin alpha-2 (ITGA2) gene C807T, integrin beta-3 (ITGB3) gene T176C polymorphisms with ischemic stroke and the effect of the polymorphisms on plasma lipid and lipoprotein levels...
  17. Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen
    W Roberts
    Centre for Atherothrombosis Research, Medical Biosciences, University of Bradford, Bradford, UK
    J Thromb Haemost 6:2175-85
    ..Thus, NO regulates platelet spreading and stable adhesion to collagen...
  18. Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease
    Liesel M FitzGerald
    Genetics Unit, Menzies Research Institute, University of Tasmania, Hobart, Australia
    Eur J Hum Genet 17:368-77
    ..the region in six selected individuals identified 15 SNPs segregating with the IBD haplotype, located within the ITGA2 gene...
  19. Inaugural article: integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin
    Neung Seon Seo
    Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:8811-8
    ....
  20. A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes
    Mikko Karjalainen
    Department of Biological and Environmental Science Nanoscience Center, University of Jyväskylä, FI 40351 Jyväskylä, Finland
    Mol Biol Cell 19:2857-69
    ..Our results together suggest that alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes...
  21. Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
    Yasushi Shintani
    Department of Oral Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Cell Biol 180:1277-89
    ..Both receptor complexes rely on the p130 Crk-associated substrate scaffold. Interestingly, Rap1, but not Rho family guanosine triphosphatases, is required for the response to collagen I...
  22. The role of extracellular matrix, integrins, and cytoskeleton in mechanotransduction of centrifugal loading
    Juan Li
    Department of Orthodontics, West China College of Stomatology, Sichuan University, 14, 3rd Section, Renmin South Road, Chengdu 610041, PR China
    Mol Cell Biochem 309:41-8
    ..The result suggested that cytoskeleton was a possible mechanical sensor to centrifugal stimuli, and the cytoskeleton regulation to centrifugal loading was in an ECM-dependent and integrin-mediated manner...
  23. Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2
    Yann Cheli
    The Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1769:546-58
    The integrin collagen receptor locus on human chromosome 5q11.2 includes the integrin genes ITGA1 and ITGA2, and the cell cycle regulation gene PELO, embedded within ITGA1 intron 1...
  24. Activated epidermal growth factor receptor induces integrin alpha2 internalization via caveolae/raft-dependent endocytic pathway
    Yan Ning
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Biol Chem 282:6380-7
    ....
  25. Assessment of the genetic component of hypertension
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Am J Hypertens 19:1158-65
    ..for age, sex, body mass index, and the prevalence of smoking revealed that four polymorphisms (1648G-->A in ITGA2, -30G-->A in GCK, A-->G in SAH, and 1117C-->A in PTGIS) were significantly (P < ...
  26. Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population
    Berthold Hoppe
    Institute of Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsklinikum Berlin, Berlin, Germany
    Thromb Haemost 96:465-70
    ....
  27. Structural and functional analysis of integrin alpha2I domain interaction with echovirus 1
    Li Xing
    Department of Biosciences, Karolinska Institute, 14157 Stockholm, Sweden
    J Biol Chem 279:11632-8
    ....
  28. Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt
    Katherine Conant
    Departments of Neurology and Neuropathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 279:8056-62
    ..Together, these results suggest that MMP-1 can stimulate dephosphorylation of Akt and neuronal death through a non-proteolytic mechanism that involves changes in integrin signaling...
  29. The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction
    H Kroll
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Germany
    Thromb Haemost 83:392-6
    ..that induce either various expression levels (C807T) or alterations of the tertiary structure (A1648G) of GPIa. Previously, we could demonstrate an association of the GPIa C807T dimorphism with nonfatal myocardial infarction...
  30. A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states
    C M Longhurst
    Department of Medicine, University of Tennessee, Memphis, TN, USA
    Eur J Biochem 263:104-11
    ..These findings imply that the platelet CD9 complex is independent of platelet activation although it is dependent upon the conformation state of alphaIIbbeta3...
  31. Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains
    V Wixler
    Institute for Biochemistry II, Medical Faculty of the University of Cologne, Germany
    FEBS Lett 445:351-5
    ..The conserved membrane proximal region of the alpha3A chain was identified as the binding site for all four proteins. They, therefore, may be involved in the regulation of general functions of integrins...
  32. Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization
    A Scherberich
    Laboratoire de Pharmacologie et Physiologie Cellulaires, Faculté de Pharmacie, Illkirch France
    Arterioscler Thromb Vasc Biol 18:1691-7
    ..CD9 was mainly associated with alpha2 and alpha3-integrins (CD49b and c) and also with alpha5-integrin to a weaker extent...
  33. Mesothelium expression of integrins in vivo and in vitro
    C A Witz
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio 78284 7836, USA
    J Soc Gynecol Investig 5:87-93
    ..CONCLUSION: Integrins are expressed by the mesothelium of the peritoneum. The mesothelium expression of integrins in vivo differs from that of the mesothelium integrin expression in monolayer culture and explant culture...
  34. Integrins in thyroid tissue: upregulation of alpha2beta1 in anaplastic thyroid carcinoma
    T Dahlman
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Eur J Endocrinol 138:104-12
    ..In the latter, a loss of E-cadherin expression was also seen. These changes in cell adhesion molecule expression strongly suggest an association with the acquisition of proliferative and invasive properties...
  35. Crystal structure of the I domain from integrin alpha2beta1
    J Emsley
    Department of Biochemistry, University of Leicester, Leicester LE1 7RH, United Kingdom
    J Biol Chem 272:28512-7
    ..Comparison with the homologous von Willebrand factor A3 domain, which also binds collagen, suggests that the two domains bind collagen in different ways...
  36. Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherin
    L Camper
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, S 221 00 Lund, Sweden
    J Cell Biol 138:1159-67
    ..Although alpha2beta1 is a receptor for both collagen type II and chondroadherin, only adhesion of cells to collagen type II was found to mediate spreading...
  37. Expression of three cell adhesion molecules in bladder carcinomas: correlation with pathological features
    A Mialhe
    Groupe de Recherches sur les Tumeurs de Vessie, Institut Albert Bonniot, Université Joseph Fourier, Grenoble, France
    Anal Cell Pathol 13:125-36
    ..Thus our results indicate that, although many invasive bladder tumours presented a disorder in expression of the two integrins alpha 2 and beta 4, E-cadherin appeared to be a better market of invasiveness in bladder carcinomas...
  38. The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2)
    S Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    J Clin Invest 92:2427-32
    The human GPIa/IIa complex, also known as integrin alpha 2 beta 1, serves as a major receptor for collagen in platelets and other cell types...
  39. Immunolocalization of alpha 2, alpha 5, and alpha 6 integrin subunits in salivary tissue and adenomas of the parotid gland
    A Franchi
    Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze, Italy
    J Oral Pathol Med 23:457-60
    ..We conclude that the pattern of a integrin subunit expression in salivary adenomas may be related to the "epithelial" or "mesenchymal" phenotype of the neoplastic cells...
  40. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
    H K Nieuwenhuis
    Nature 318:470-2
    ..We now report a defect of the platelet plasma membrane glycoprotein composition in a patient whose platelets are totally unresponsive to collagen...
  41. The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain
    Y Takada
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Cell Biol 109:397-407
    VLA-2 (also called gpIa/IIa on platelets) is a collagen receptor with a unique alpha subunit and a beta subunit common to other adhesion receptors in the VLA/integrin family...
  42. Structural basis of collagen recognition by integrin alpha2beta1
    J Emsley
    Department of Biochemistry, University of Leicester, United Kingdom
    Cell 101:47-56
    ..The structural features observed here may represent a general mechanism for integrin-ligand recognition...
  43. Integrin expression in oral hairy leukoplakia and normal tongue epithelium
    N Chainani Wu
    Department of Stomatology, University of California, San Francisco, San Francisco, CA 94143, USA
    Oral Dis 6:234-40
    ..CONCLUSION: Integrins alpha 2, alpha 3, alpha 6, alpha v, beta 1 are expressed in HL and the expression pattern is not different from that of normal oral mucosa. alpha 5 is not expressed in HL or in normal oral epithelium...
  44. CXC chemokine receptor 3 expression on CD34(+) hematopoietic progenitors from human cord blood induced by granulocyte-macrophage colony-stimulating factor: chemotaxis and adhesion induced by its ligands, interferon gamma-inducible protein 10 and monokine
    T Jinquan
    Laboratory of Medical Allergology, Allergy Unit, National University Hospital, Copenhagen, Denmark
    Blood 96:1230-8
    ..gamma IP-10-induced and Mig-induced up-regulation of integrins (CD49a and CD49b) was found to play a crucial role in adhesion of GM-CSF-stimulated CD34(+) progenitors...
  45. Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood
    Pia R M Siljander
    Department of Biochemistry, University of Cambridge, Main Bldg, Downing Site, Tennis Court Rd, CB2 1QW Cambridge, United Kingdom
    Blood 103:1333-41
    ....
  46. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke
    V J Cole
    Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia
    J Thromb Haemost 1:963-70
    ..Our results do not support a role for the integrin alpha2 C807T and GPVI Q317L polymorphisms in the development of first-ever ischemic stroke. However, larger studies are required to confirm this...
  47. Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Thromb Haemost 89:142-8
    ..019). These results suggest the hypothesis that genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy.
  48. Platelet collagen receptor GPIa (C807T/HPA-5) haplotype is not associated with an increased risk of fatal coronary events in middle-aged men
    Jussi Mikkelsson
    Medical School building B, University of Tampere and Tampere University Hospital, P O Box 607, FIN 33014 Tampere, Finland
    Atherosclerosis 165:111-8
    Platelet GPIa/IIa receptors play key roles in the adhesion of platelets to collagen during the formation of coronary thrombosis...
  49. Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions
    Takako Nishiya
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Blood 100:136-42
    ..Further, the anti-GPIa antibody (Gi9) inhibited liposome adhesion more than GUR83-35 at all shear rates tested...
  50. Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3
    Atsushi Kato
    Division of Hematology, Department of Internal Medicine and Division of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:28934-41
    ..As Aup1 possesses domains related to signal transduction, these results suggest involvement of Aup1 in the integrin signaling...
  51. Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review
    E R Morrison
    Department of Medicine and Therapeutics, University of Aberdeen, Scotland
    Thromb Haemost 87:779-85
    ..which appear to be associated with FVL and, to a lesser extent, MTHFR C677T. There is little value in antenatal screening for prothrombotic polymorphisms to predict the development of pre-eclampsia or gestational hypertension...
  52. Characterization of cultured human prostatic epithelial cells by cluster designation antigen expression
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Cell Tissue Res 305:389-97
    ..Presence of CD44, CD49b, CD49f, and CD104 and absence of CD57 suggests that cultured cells were derived from basal cells of prostatic ..
  53. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen
    J A Dumin
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:29368-74
    ....
  54. Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction
    T P Stricker
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:29375-81
    ..The alpha(2) integrin/MMP-1 interaction described here extends an emerging paradigm in matrix biology involving anchoring of proteinases to the cell surface to regulate their biological activities...
  55. Allele-dependent transcriptional regulation of the human integrin alpha2 gene
    B Jacquelin
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis of the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 97:1721-6
    ....
  56. Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8
    A Sonnenberg
    Department of Immunohaematology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    J Cell Biol 110:2145-55
    ..Adhesion to E3 may also be brought about by other receptor molecules, possibly proteoglycans, not belonging to the integrin family...