ITCH

Summary

Gene Symbol: ITCH
Description: itchy E3 ubiquitin protein ligase
Alias: AIF4, AIP4, NAPP1, dJ468O1.1, E3 ubiquitin-protein ligase Itchy homolog, NFE2-associated polypeptide 1, atrophin-1 interacting protein 4, dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)), itchy E3 ubiquitin protein ligase homolog
Species: human

Top Publications

  1. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
  2. pmc Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]
    King Ching Ho
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 108:4870-5. 2011
  3. pmc Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:22166-76. 2008
  4. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
  5. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
  6. doi Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity
    Zaidoun Salah
    The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cancer Res 71:2010-20. 2011
  7. ncbi Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
  8. ncbi The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases
    Richard Kitching
    Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Biochim Biophys Acta 1639:104-12. 2003
  9. doi A regulatory circuit controlling Itch-mediated p73 degradation by Runx
    Dan Levy
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel
    J Biol Chem 283:27462-8. 2008
  10. doi Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling
    Bilal A Azakir
    Departement de sciences biologiques, Universite de Montreal, Montreal, QC H3C3J7, Canada
    Cell Signal 21:1326-36. 2009

Detail Information

Publications170 found, 100 shown here

  1. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
    The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process...
  2. pmc Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]
    King Ching Ho
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 108:4870-5. 2011
    ..In this study, we have identified Itch, a HECT class E3 ubiquitin ligase, as a unique binding partner of LATS1...
  3. pmc Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    Sudha K Shenoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:22166-76. 2008
    ..ubiquitination and lysosomal degradation, whereas siRNA targeting the closely related E3 ligases Nedd4-2 or AIP4 did not...
  4. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    ..Here we demonstrate that the regulatory molecule TAX1BP1 recruited the E3 ligase Itch to A20 via two 'PPXY' motifs...
  5. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
    ....
  6. doi Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity
    Zaidoun Salah
    The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cancer Res 71:2010-20. 2011
    ..In this study, we report that the E3 ubiquitin ligase ITCH regulates stability of LATS1, a serine/threonine kinase in the Hippo pathway, through protein-protein interaction ..
  7. ncbi Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
    ..mechanism involves regulation of the E3 Ub ligase, for example, the JNK-dependent phosphorylation and activation of Itch E3 ligase, which controls the turnover of Jun proteins and T cell differentiation...
  8. ncbi The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases
    Richard Kitching
    Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Biochim Biophys Acta 1639:104-12. 2003
    ..Our GST-pulldown and immunoprecipitation results indicate that RNF11 interacts with the E3 ligase AIP4 when coexpressed with RNF11 in mammalian cells.
  9. doi A regulatory circuit controlling Itch-mediated p73 degradation by Runx
    Dan Levy
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100 Israel
    J Biol Chem 283:27462-8. 2008
    ..The level of p73 is regulated by the E3 ligase Itch. Itch levels are sharply reduced in response to DNA damage with concomitant p73 accumulation and activation...
  10. doi Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling
    Bilal A Azakir
    Departement de sciences biologiques, Universite de Montreal, Montreal, QC H3C3J7, Canada
    Cell Signal 21:1326-36. 2009
    ..we demonstrate that treatment of cells with EGF leads to JNK-dependent phosphorylation of the ubiquitin ligase Itch, stimulating Itch ligase activity...
  11. doi Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment
    E Santonico
    Department of Molecular Biology, Tor Vergata University of Rome, Rome, Italy
    Oncogene 29:5604-18. 2010
    ..moieties and that loss of acylation severely impairs the in vivo ubiquitination mediated by the HECT E3-ligases Itch and Nedd4...
  12. doi The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid
    Bilal A Azakir
    Departement de sciences biologiques, Universite de Montreal, Montreal, Quebec, Canada
    FEBS J 277:1319-30. 2010
    ..Here, we provide evidence that tBid is a substrate of the ubiquitin ligase Itch, which can specifically interact with and ubiquitinate tBid, but not intact Bid...
  13. pmc The ubiquitin-protein ligase Itch regulates p73 stability
    Mario Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 24:836-48. 2005
    ..However, unlike p53, p73 binds to, but is not degraded by, MDM2. Here we describe the binding of p73 to Itch, a Hect ubiquitin-protein ligase...
  14. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
    ..Arrestin 1 interacts with, and acts as an adaptor for AIP4, an E3 ubiquitin ligase responsible for TRPV4 ubiquitination...
  15. pmc The E3 ubiquitin ligase Itch controls the protein stability of p63
    Mario Rossi
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 103:12753-8. 2006
    ..that the Hect (homologous to the E6-associated protein C terminus)-containing Nedd4-like ubiquitin protein ligase Itch binds, ubiquitylates, and promotes the degradation of p63...
  16. pmc The role of ITCH protein in human T-cell leukemia virus type 1 release
    Batsukh Dorjbal
    HIV Drug Resistance Program, NCI Frederick, Frederick, Maryland 21702, USA
    J Biol Chem 286:31092-104. 2011
    ..We tested nine members of the Nedd4 family ULs and found that ITCH is the main contributor to HTLV-1 budding...
  17. ncbi The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X
    Rania Mouchantaf
    Départment de Sciences Biologiques, Universite de Montreal, Station Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 281:38738-47. 2006
    b>Itch is a ubiquitin ligase that has been implicated in the regulation of a number of cellular processes...
  18. pmc Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
    Ewen Gallagher
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:1717-22. 2006
    The E3 ubiquitin (Ub) ligase Itch is a critical regulator of T helper 2 (Th2) cytokine production through its ability to induce Ub-dependent JunB degradation...
  19. pmc Cbl-b and itch: key regulators of peripheral T-cell tolerance
    K Venuprasad
    Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:3009-12. 2010
    E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases...
  20. pmc The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
    K Venuprasad
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 9:245-53. 2008
    ..However, the molecular mechanisms leading to Foxp3 induction remain unclear. Here we show that Itch-/- T cells were resistant to TGF-beta treatment and had less Foxp3 expression...
  21. ncbi Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    Melanie A McGill
    Department of Medical Biophysics, University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:23196-203. 2003
    ..In agreement we demonstrate that Numb interacts with the cytosolic HECT domain-containing E3 ligase Itch and that Numb and Itch act cooperatively to promote ubiquitination of membrane-tethered Notch1...
  22. doi Identification of novel spartin-interactors shows spartin is a multifunctional protein
    Malgorzata Milewska
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Ireland
    J Neurochem 111:1022-30. 2009
    ..published information about spartin interaction with ubiquitin and the E3 ubiquitin-protein ligases, AIP4/Itch and AIP5/WWP1...
  23. pmc Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
    Christopher Hooper
    Department of Molecular Pharmacology and Therapeutics, Loyola Chicago University, Maywood, IL, USA
    BMC Biol 8:72. 2010
    ..belong to the neural precursor cell-expressed developmentally downregulated gene (Nedd4) family, including atrophin-1-interacting protein 4 (AIP4/ITCH). However, the biological importance of the spartin-AIP4 interaction remains unknown.
  24. pmc Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5
    Thomas L Edwards
    University of Liverpool, UK
    Biochem J 423:31-9. 2009
    ..demonstrate that it interacts via a PPXY motif with the ubiquitin E3 ligases AIP4 [atrophin-interacting protein 4; ITCH (itchy E3 ubiquitin protein ligase homologue] [corrected] and AIP5 (WWP1)...
  25. ncbi AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism
    Francois Lallemand
    INSERM U482, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    J Biol Chem 280:27645-53. 2005
    ..Using the two-hybrid screen, we identified atrophin 1-interacting protein 4 (AIP4) as an E3 ubiquitin ligase that specifically targets Smad7 for ubiquitin-dependent degradation without affecting ..
  26. ncbi SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling
    Hong Liang Rui
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:42981-6. 2002
    ..Taken together, we demonstrate that sumoylation plays a role for Axin to function in the JNK pathway...
  27. pmc Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes
    Deyu Fang
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0650, USA
    Proc Natl Acad Sci U S A 101:14782-7. 2004
    ..Mutation of a recognition sequence for the E3 ligase Itch/AIP4 prevented Jun ubiquitination and stabilized it in cells...
  28. doi Itch self-polyubiquitylation occurs through lysine-63 linkages
    Flavia Scialpi
    IDI IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochem Pharmacol 76:1515-21. 2008
    b>Itch, an E3 protein ubiquitin ligase (E3), which belongs to the homologous to E6-AP carboxy terminus (HECT)-type subfamily, catalyzes its own ubiquitylation...
  29. ncbi The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
    W L Perry
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Nat Genet 18:143-6. 1998
    ..affects two loci: agouti and another, as yet unidentified locus designated itchy (the provisional gene symbol is Itch), that is responsible for the immunological phenotype of a18H mice...
  30. ncbi The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system
    Annie Angers
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 279:11471-9. 2004
    ..We have identified the E3 ubiquitin ligase itch/AIP4 as an endophilin A1-binding partner...
  31. pmc A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover
    Scott W Eastman
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 184:881-94. 2009
    ..These experiments suggest functions for ubiquitin ligases and SPG20 in the regulation of LD turnover and potential pathological mechanisms in Troyer syndrome...
  32. pmc A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    Amith Panner
    Brain Tumor Research Center, Department of Neurological Surgery and University of California San Francisco Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
    Cancer Res 69:7911-6. 2009
    ..Total levels of the candidate FLIP(S) E3 ubiquitin ligase atrophin-interacting protein 4 (AIP4) were comparable in PTEN wild-type (WT) and PTEN mutant GBM cells, although in PTEN-deficient cells, AIP4 was ..
  33. pmc Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
    Patricia Chastagner
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO Rep 7:1147-53. 2006
    Deltex (DTX) and AIP4 are the human orthologues of the Drosophila deltex and Suppressor of deltex, which have been genetically described as being antagonistically involved in the Notch signalling pathway...
  34. pmc Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
    Thomas Mund
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    EMBO Rep 10:501-7. 2009
    ..membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them...
  35. pmc The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels
    Tomasz Wegierski
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
    EMBO J 25:5659-69. 2006
    ..of TRPV4 is dramatically increased by the HECT (homologous to E6-AP carboxyl terminus)-family ubiquitin ligase AIP4 without inducing degradation of this channel...
  36. ncbi N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking
    Linda M Shearwin-Whyatt
    Hanson Institute, IMVS, Frome Road, Adelaide, SA 5000, Australia
    J Cell Sci 117:3679-89. 2004
    ..We propose that N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery...
  37. ncbi Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
    Lucia Di Marcotullio
    Department of Experimental Medicine and Pathology, University La Sapienza, Roma, 324 Viale Regina Elena, 00161 Roma, Italy
    Nat Cell Biol 8:1415-23. 2006
    ..We demonstrate that the Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell ..
  38. ncbi Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways
    Libing Feng
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 279:29681-90. 2004
    Atrophin-1-interacting protein 4 (AIP4) is the human homolog of the mouse Itch protein (hItch), an E3 ligase for Notch and JunB...
  39. ncbi Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
    J D Wood
    Division of Neurobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 2196, USA
    Mol Cell Neurosci 11:149-60. 1998
    ..AIP2/WWP2, AIP4, and AIP5/WWP1 are highly homologous, each having four WW domains and a HECT domain characteristic of ubiquitin ..
  40. ncbi Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase
    L Qiu
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 275:35734-7. 2000
    Genetic studies identified Itch, which is a homologous to the E6-associated protein carboxyl terminus (Hect) domain-containing E3 ubiquitin-protein ligase that is disrupted in non-agouti lethal mice or Itchy mice...
  41. pmc Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
    G Winberg
    Karolinska Institutet, Microbiology and Tumor Biology Center MTC, SE 171 77 Stockholm, Sweden
    Mol Cell Biol 20:8526-35. 2000
    ..the PPPPY motifs of LMP2A bind multiple WW domains of E3 protein-ubiquitin ligases of the Nedd4 family, including AIP4 and KIAA0439, and demonstrate that AIP4 and KIAA0439 form physiological complexes with LMP2A in EBV-positive B ..
  42. ncbi N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein
    Kieran F Harvey
    Hanson Center for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia
    J Biol Chem 277:9307-17. 2002
    ..Based on previous observations in yeast, we propose that N4WBP5 may act as an adaptor for Nedd4-like proteins and their putative targets to control ubiquitin-dependent protein sorting and trafficking...
  43. ncbi The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    D Levy
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Cell Death Differ 14:743-51. 2007
    ..The ubiquitin E3 ligase Itch, like Yap1, interacts with p73...
  44. pmc The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
    Andrew Oberst
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 104:11280-5. 2007
    ..Here, we describe a previously unrecognized functional interaction between N4BP1 and Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity...
  45. ncbi The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
    Adriano Marchese
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Cell 5:709-22. 2003
    ..Here we report that the Nedd4-like E3 ubiquitin ligase AIP4 mediates ubiquitination of CXCR4 at the plasma membrane, and of the ubiquitin binding protein Hrs on endosomes...
  46. ncbi Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4
    Deepali Bhandari
    Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    J Biol Chem 282:36971-9. 2007
    ..CXCR4 is rapidly targeted for lysosomal degradation by the E3 ubiquitin ligase atrophin-interacting protein 4 (AIP4)...
  47. ncbi The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitin
    Sylvie Dussart
    INSERM Unit 372, Universite de la Mediterranee, 163 Avenue de Luminy, BP178, 13276 Marseille Cedex 09, France
    Biochem Biophys Res Commun 315:66-72. 2004
    ..Here, we show that Vif binds to hNedd4 and AIP4, two HECT E3 ubiquitin ligases. WW domains present in those HECT enzymes contribute to the binding of Vif...
  48. pmc The effect of cyclic AMP elevating agents on bradykinin- and carbachol-induced signal transduction in canine cultured tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 112:781-8. 1994
    ..b>AIF4-induced IPs accumulation was not affected by CTX, forskolin, or dibutyryl cyclic AMP treatment, supporting the ..
  49. ncbi [Clinical manifestation and patho-typing of biliary cast syndrome in patients after orthotopic liver transplantation]
    Xiao Dan Zhu
    Institute of Liver Transplantation, General Hospital of Chinese Armed Police Forces, Beijing 100039, China
    Zhonghua Wai Ke Za Zhi 46:728-32. 2008
    ..To summarize the Patho-typing and the clinical manifestation of biliary cast syndrome (BCS) in patients after orthotopic liver transplantation...
  50. ncbi Disorders of keratinization: diagnosis and management
    Tor Shwayder
    Pediatric Dermatology, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Am J Clin Dermatol 5:17-29. 2004
    ..Treatment is with aggressive moisturization. Hydrocortisone creams may be needed to control itch. Recessive X-linked ichthyosis is due to a deficiency of cholesterol sulfatase...
  51. ncbi The efficacy of Prrrikweg gel in the treatment of insect bites: a double-blind, placebo-controlled clinical trial
    N Hill
    London School of Hygiene and Tropical Medicine, London, UK
    Pharm World Sci 18:35-41. 1996
    ..5, 1, 26.5, and 48 h post-bite to compare the itch-relieving efficacy of the two treatments...
  52. ncbi Itch and atopic dermatitis: clinical and experimental studies
    C F Wahlgren
    Department of Dermatology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Acta Derm Venereol Suppl (Stockh) 165:1-53. 1991
    The aims of the study were to develop and evaluate methods for quantitative measurement of itch, to investigate the perception of itch in patients with atopic dermatitis (AD), and to measure itch in such patients during treatment with H1-..
  53. pmc Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease
    Rebecca Saich
    The Department of Gastroenterology, The John Radcliffe Hospital, Headley Way, Headington, Oxford, Oxfordshire, United Kingdom
    World J Gastroenterol 14:331-7. 2008
    ..Symptoms include itch and lethargy and in advanced cases cholangitis and end-stage liver disease, however increasing numbers of ..
  54. ncbi Endometrial responsiveness to oxytocin during diestrus and early pregnancy in pigs is not controlled solely by changes in oxytocin receptor population density
    T E Ludwig
    Department of Animal Sciences, Washington State University, Pullman 99164 6353, USA
    Biol Reprod 58:769-77. 1998
    ..05), and during pregnancy only on Day 12 (p < 0.05). Activation of G protein by aluminum fluoride (AIF4-) treatment maximally stimulated (p < 0...
  55. pmc Late domain-independent rescue of a release-deficient Moloney murine leukemia virus by the ubiquitin ligase itch
    Joshua A Jadwin
    Laboratory of Molecular Microbiology, NIAID, NIH, 4 Center Dr, Bethesda, MD 20892, USA
    J Virol 84:704-15. 2010
    ..However, low-level expression of the ubiquitin ligase Itch potently rescued the release and infectivity of MoMLV lacking PPPY function...
  56. doi Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes
    M Kobayashi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Br J Dermatol 160:297-304. 2009
    ..Histamine, which is well known for itch and allergy, is closely associated with innate immunity, but its influence on epidermal innate immunity is still ..
  57. ncbi Relationship between specific binding of 125I-omega-conotoxin GVIA and GTP binding protein: effects of the GTP analogues, mastoparan and A1F4-
    S Ichida
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kinki University, Higashi Osaka, Japan
    Biochim Biophys Acta 1325:215-25. 1997
    ..endogenous GTP binding protein (G protein) was activated by GTP analogues, mastoparan (MP) and aluminum fluoride (AIF4-; AICl3 + NaF)...
  58. ncbi Progressive macular hypomelanosis: an overview
    Germaine N Relyveld
    The Netherlands Institute for Pigment Disorders, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Clin Dermatol 8:13-9. 2007
    ..There is no itch, pain, or preceding inflammation...
  59. doi Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
    L Di Marcotullio
    Department of Molecular Medicine, Sapienza University, Rome, Italy
    Oncogene 30:65-76. 2011
    ..of an ubiquitin-mediated mechanism of Gli1 degradation, promoted by the coordinated action of the E3 ligase Itch and the adaptor protein Numb...
  60. ncbi Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice
    Y Kobayashi
    Kyowa Hakko Kogyo Co, Ltd Tsukuba Research Laboratories, Ibaraki, Japan
    Phytomedicine 10:657-64. 2003
    ..Since it is reported that an injection of compound 48/80, but not histamine, induced scratching behaviour due to itch but not to pain in ddY mice (Kuraishi et al...
  61. pmc The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups
    Denise Globe
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Health Qual Life Outcomes 7:62. 2009
    ....
  62. ncbi Treatment of pruritus with topically applied opiate receptor antagonist
    Paul L Bigliardi
    Department of Dermatology, CHUV Hôpital Beaumont, Lausanne, Switzerland
    J Am Acad Dermatol 56:979-88. 2007
    Pruritus is the most common and distressing skin symptom, and treatment of itch is a problem for thousands of people. The currently available therapies are not very effective...
  63. ncbi Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine
    S L Jinks
    Section of Neurobiology, Physiology and Behavior, University of California, Davis, California 95616, USA
    J Neurophysiol 84:616-27. 2000
    ..ic) delivery of histamine and other irritant chemicals, and thus might be involved in signaling sensations of itch or chemogenic pain...
  64. ncbi Ivermectin is better than benzyl benzoate for childhood scabies in developing countries
    P A Brooks
    Outpatients Department, Vila Central Hospital, Port Vila, Vanuatu
    J Paediatr Child Health 38:401-4. 2002
    ..To compare single dose oral ivermectin with topical benzyl benzoate for the treatment of paediatric scabies...
  65. ncbi Effectiveness of the nursing programme 'Coping with itch': a randomized controlled study in adults with chronic pruritic skin disease
    H van Os-Medendorp
    Department of Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Br J Dermatol 156:1235-44. 2007
    The nursing programme 'Coping with Itch' aims at reducing itch and at helping patients with chronic pruritic skin diseases cope with itch. The programme consists of educational and cognitive behavioural interventions...
  66. ncbi [Clinical effects of olopatadine hydrochloride on pruritus in skin diseases]
    Mariko Niide
    Department of Dermatology, Tokyo Medical University
    Arerugi 55:1327-36. 2006
    ..The clinical effects of second generation antihistamines on pruritus caused by various skin diseases were examined by keeping a daily record of their effects...
  67. doi Evaluation of sensory irritation caused by topical medications using a novel technique
    Annemarie Uliasz
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Dermatol 49:269-71. 2010
    ..The aim of this study was to evaluate and compare the sensory irritation caused by hydrocortisone butyrate lipocream 0.1% using a non-invasive and inexpensive technique...
  68. ncbi A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
    Yan Gang Sun
    Department of Anesthesiology, Washington University School of Medicine Pain Center, St Louis, Missouri 63110, USA
    Nature 448:700-3. 2007
    ..Chronic itch represents a significant clinical problem resulting from renal diseases and liver diseases, as well as several ..
  69. ncbi Lack of efficacy of topical capsaicin in serotonin-induced itch
    E Weisshaar
    Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Germany
    Skin Pharmacol Appl Skin Physiol 13:1-8. 2000
    ..In a previous study, we showed a significantly inhibitory effect of topical CAP treatment on histamine-induced itch and cutaneous vascular reactions in healthy subjects compared to atopic eczema patients...
  70. ncbi Efficacy of naltrexone on acetylcholine-induced alloknesis in atopic eczema
    G Heyer
    Department of Dermatology, Friedrich Alexander University of Erlangen Nuremberg, Hartmannstrasse, Erlangen, Germany
    Exp Dermatol 11:448-55. 2002
    ..our present experiments similar to former experiments evaluating both peripheral cutaneous sensations and central itch procession in order to gain more information about the possible distribution of opioid receptors and their ..
  71. pmc Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice
    H J Kim
    Laboratory of Skin Research AmorePacific Corporation R and D Center, Gyeonggi Do, Korea
    Br J Pharmacol 154:1073-8. 2008
    ....
  72. ncbi Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled study
    Lawrence A Schachner
    Division of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida, USA
    Pediatrics 116:e334-42. 2005
    ..This study was designed to compare the safety and efficacy of tacrolimus ointment 0.03% with vehicle ointment for the treatment of mild to moderate atopic dermatitis (AD) in pediatric patients...
  73. ncbi Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata
    Kazumoto Katagiri
    Department of Anatomy, Biology and Medicine Dermatology, Faculty of Medicine, Oita University, Oita, Japan
    J Dermatol 33:75-9. 2006
    ..However, it is unclear whether antihistamines inhibit the itch of eczematous diseases in the absence of topical corticosteroids...
  74. ncbi Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice
    M Seike
    Department of Dermatology, Kochi Medical School, Okohcho, Nankoku Kochi, 783 8505, Japan
    Exp Dermatol 14:169-75. 2005
    A neuronal system dedicated to itch consists of primary afferent and spinothalamic projection neurons. Histamine is thought to be one of the main mediators for the transmission of itch sensation...
  75. doi Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice
    Yu Zhu
    Department of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China
    Int Immunopharmacol 9:1332-6. 2009
    Protease-activated receptor-2 (PAR2) has been shown to play a key role in the pathophysiology of itch. However, the precise mechanism of PAR2-mediated itch remains largely unknown...
  76. ncbi Prurigo: diagnosis and management
    Joanna Wallengren
    Department of Dermatology, University Hospital, Lund, Sweden
    Am J Clin Dermatol 5:85-95. 2004
    Prurigo is a condition of nodular cutaneous lesions that itch (pruire) intensely. Although the acute form can be caused by insect stings, most of the subacute and chronic forms appear to be idiopathic...
  77. ncbi From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch
    Petra Arck
    Center for Internal Medicine and Dermatology, Charite, University Medicine Berlin, and Department of Dermatology, University Hospital Schleswig Holstein, Lubeck, Germany
    Neuroimmunomodulation 13:347-56. 2006
    ..b>Itch (pruritus) is perhaps the most common symptom associated with a majority of these inflammatory skin diseases, and ..
  78. ncbi [Swimmer's itch in Landmannalaugar, Iceland]
    Karl Skirnisson
    Institute for Experimental Pathology, University of Iceland, Keldur v Vesturlandsveg, 112 Reykjavik, Iceland
    Laeknabladid 91:729-36. 2005
    Swimmer's itch (SI) or human cercarial dermatitis is caused by free-swimming larvae of bird parasites of the family Schistosomatidae (Trematoda) which have penetrated thorough the skin...
  79. ncbi [Anaphylaxis due to peach with negative ImmunoCAP result to peach allergens, including rPru p 1, rPru p 3, AND rPru p 4: a report of two cases]
    Nobuko Maeda
    Department of Dermatology, Yokohama City University
    Arerugi 58:140-7. 2009
    ..Case 1 is a 35-year-old man, who felt an itch in his oral cavity immediately after ingesting a whole fresh peach...
  80. ncbi Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 114:292-7. 2010
    Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G...
  81. doi Chronic pruritus: targets, mechanisms and future therapies
    Esther Pogatzki-Zahn
    Department of Anesthesiology and Intensive Care, Competence Center for the Diagnostic and Therapy of Chronic Pruritus, University of Munster, Munster, Germany
    Drug News Perspect 21:541-51. 2008
    Pruritus (itch) is an unpleasant sensation inducing the desire to scratch. Chronic pruritus (>6 weeks' duration) is a major and distressing symptom of many diseases of dermatological, systemic, neurological or psychogenic origin...
  82. pmc Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 329:314-23. 2009
    Pruritus (itch) is a common cause of discomfort by dermatological disorders. Several peripherally and centrally mediated pathologies that induce pruritus do not generally respond to typical allergenic and anti-inflammatory treatments...
  83. doi Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease
    S Cialfi
    Department of Experimental Medicine, University La Sapienza, 00161, Rome, Italy
    Br J Dermatol 162:518-26. 2010
    ..While a strong relationship exists between mutations in the gene that encodes the Ca(2+)/Mn(2+)-adenosine triphosphatase ATP2C1 and HHD, we still have little understanding of how these mutations affect manifestations of the disease...
  84. pmc Effects of butorphanol on morphine-induced itch and analgesia in primates
    Heeseung Lee
    Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea
    Anesthesiology 107:478-85. 2007
    ..demonstrated that both MOR antagonists and KOR agonists are effective in alleviating intrathecal morphine-induced itch in primates...
  85. ncbi Prevalence and predictors of psychosocial morbidity in patients with chronic pruritic skin diseases
    H van Os-Medendorp
    Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Eur Acad Dermatol Venereol 20:810-7. 2006
    b>Itch is a major symptom of many skin diseases and causes patients considerable distress, adversely affecting quality of life. Feelings of helplessness and lack of control can influence the perceived itch and psychosocial complaints.
  86. ncbi Pruritogenic mediators in psoriasis vulgaris: comparative evaluation of itch-associated cutaneous factors
    M Nakamura
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Dermatol 149:718-30. 2003
    ..Although some patients with psoriasis vulgaris also complain of severe pruritus, the data available regarding pruritus in psoriasis are sparse...
  87. doi Naltrexone for the management of post-burn pruritus: A preliminary report
    L LaSalle
    Hôpital de réadaptation Villa Medica, Montreal, Quebec, Canada
    Burns 34:797-802. 2008
    ..Thus, burn patients who were dissatisfied with itch relief obtained after a course of traditional therapy were offered naltrexone...
  88. ncbi Effect of oral granisetron in uremic pruritus
    Pouran Layegh
    Department of Dermatology, Qaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
    Indian J Dermatol Venereol Leprol 73:231-4. 2007
    Renal itch is a relatively common and distressing problem for patients with chronic renal failure. Granisetron, is a potent and selective inhibitor of 5-HT3 receptors...
  89. ncbi Itch characteristics in Chinese patients with atopic dermatitis using a new questionnaire for the assessment of pruritus
    Gil Yosipovitch
    National Skin Center, National Medical Research Council, Ministry of Health, 1 Mandalay Road, Singapore 308205
    Int J Dermatol 41:212-6. 2002
    ..Although pruritus is the predominant and commonest feature of atopic dermatitis, its clinical characteristics have not been explored...
  90. doi Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 1094, Japan
    J Invest Dermatol 129:2854-60. 2009
    ..In the present study, we investigated the itch-eliciting activity of SPC and related substances and the mechanisms of SPC action in mice...
  91. doi Efficacy of sublingual specific immunotherapy in intermittent and persistent allergic rhinitis in children: an observational case-control study on 171 patients. The EFESO-children multicenter trial
    Franca Acquistapace
    Pediatric Department, Fatebenefratelli e Oftalmico Hospital, Milan, Italy
    Pediatr Allergy Immunol 20:660-4. 2009
    ..Main outcomes of the study were the rhinoconjunctivitis symptom score (SS) (sneezing, rhinorrea, nasal itch, congestion, ocular itch and watery eyes) with a ranging scale from 0 (=no symptoms) to 3 (=severe symptoms) and ..
  92. pmc The role of central mu opioid receptors in opioid-induced itch in primates
    M C H Ko
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Pharmacol Exp Ther 310:169-76. 2004
    Pruritus (itch sensation) is a significant clinical problem. The aim of this study was to elucidate the roles of opioid receptor types and the site of action in opioid-induced itch in monkeys...
  93. pmc Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P
    Ewan St John Smith
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin Buch, Germany
    Mol Pain 6:29. 2010
    ..in which sensory neurons expressing the capsaicin activated ion channel TRPV1 are required for histamine-induced itch and subsequent scratching behavior...
  94. ncbi Cutaneous field stimulation with moderate intensity current induces nerve proliferation in rat skin but has no effect on dorsal root ganglia
    Joanna Wallengren
    Department of Dermatology, Section for Neuroendocrine Cell Biology, University Hospital, Lund, Sweden
    Acta Derm Venereol 85:324-8. 2005
    Cutaneous field stimulation is used to treat localized itch. The aim of the present study was to determine whether such treatment induces neurochemical changes in the dorsal root ganglia in 30 rats using a pan-neuronal marker protein gene-..
  95. doi Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin
    P Gazerani
    Center for Sensory Motor Interaction, Department of Health Sciences and Technology, Aalborg University, DK 9220 Aalborg, Denmark
    Br J Dermatol 161:737-45. 2009
    ..BoNT/A is believed to be effective against itch as it inhibits the release of acetylcholine as well as some other substances that may be involved in itch.
  96. pmc Validity and reliability of patient reported outcomes used in psoriasis: results from two randomized clinical trials
    Richard Shikiar
    Center for Health Outcomes Research, MEDTAP International, Inc, Seattle, WA USA
    Health Qual Life Outcomes 1:53. 2003
    ..Patient reported measures of psoriasis-related functionality and health-related quality of life and of psoriasis-related symptom assessments were included as part of the trials...
  97. doi New treatment strategy and assessment questionnaire for external auditory canal pruritus: topical pimecrolimus therapy and Modified Itch Severity Scale
    B Acar
    Department of Otorhinolaryngology, Kecioren Training and Research Hospital, Ankara, Turkey
    J Laryngol Otol 124:147-51. 2010
    We aimed to compare the efficacy of topical pimecrolimus versus hydrocortisone in treating external auditory canal pruritus, using the Modified Itch Severity Scale as an assessment tool.
  98. ncbi A new standardized method of evaluating cutaneous irritation from topical medications
    Annemarie Uliasz
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cutis 82:75-7. 2008
    ..A negative control (petrolatum ointment), a positive control (an over-the-counter [OTC] anti-itch preparation containing benzyl alcohol), and a test product (fluticasone propionate lotion 0...
  99. ncbi Treatment of pruritus associated with systemic disorders in the elderly: a review of the role of new therapies
    Ann Lonsdale-Eccles
    Department of Dermatology, The James Cook University Hospital, Middlesbrough, UK
    Drugs Aging 20:197-208. 2003
    ..In systemic disorders, correction of the underlying disorder alleviates itch. However, when this cannot be achieved, a symptomatic approach is required...
  100. ncbi Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice
    J Kamei
    Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Tokyo 142 8501, Shinagawa, Japan
    Eur J Pharmacol 418:141-5. 2001
    ..that scratching induced by norbinaltorphimine, a selective kappa-opioid receptor antagonist, is due to an itch sensation, using compound 48/80 as control pruritogenic agent. When norbinaltorphimine was injected s.c...
  101. pmc Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study
    Leon H Kircik
    Clinical Associate Professor of Dermatology, Mount Sinai Medical Center and Indiana University School of Medicine Director, Physician Skin Care, PLLC, and DermResearch, PLLC, Louisville, Kentucky
    J Clin Aesthet Dermatol 4:48-50. 2011
    b>Itch is the most common symptom among patients presenting to the dermatology clinic. Scratching can cause mechanical trauma to the skin, further damaging the epidermal barrier and its function...

Research Grants76

  1. MOLECULAR MECHANISMS OF THE ITCH SENSATION IN THE SPINAL CORD
    ZHOUFENG CHEN; Fiscal Year: 2010
    ..by applicant): The long-term objective of this proposal is to study the molecular mechanisms that underlie itch sensation at the spinal level...
  2. Itch, proteases and protease-activated receptors
    Ethan A Lerner; Fiscal Year: 2010
    ..It can be difficult to treat, as few specific inhibitors of itch are available and the mechanism that triggers the sensation of itch is not clear...
  3. MOLECULAR MECHANISMS OF THE ITCH SENSATION IN THE SPINAL CORD
    ZHOUFENG CHEN; Fiscal Year: 2009
    Chronic itch or pruritus represents a significant clinical problem for which no effective drugs are available. Molecular and cellular mechanisms of chronic pruritus are not well understood and understudied...
  4. Skin-Brain Mechanisms of Pruritus in Health and Disease
    Gil Yosipovitch; Fiscal Year: 2010
    ..Recent research has shown a central processing of experimentally-induced itch in healthy subjects but this has not been assessed in disease states as of yet...
  5. Sertoli cell injury and mechanisms of testicular germ cell apoptosis
    John H Richburg; Fiscal Year: 2010
    ..Our preliminary data suggest that the E3 ligase, Itch, ubiquitinates c-FLIP in germ cells secondary to MEHP- induced Sertoli cell injury...
  6. A PTEN-regulated ubiquitin switch controlling TRAIL sensitivity in GBM
    RUSSELL PIEPER; Fiscal Year: 2009
    ..of FLIPs have not been described, although we have identified two involved proteins; an E3 ubiquitin ligase called AIP4 that directly interacts with, ubiquitinates, and destabilizes FLIPs, and a ubiquitin-removing enzyme called USP8 ..
  7. A PTEN-regulated ubiquitin switch controlling TRAIL sensitivity in GBM
    Russell O Pieper; Fiscal Year: 2010
    ..of FLIPs have not been described, although we have identified two involved proteins;an E3 ubiquitin ligase called AIP4 that directly interacts with, ubiquitinates, and destabilizes FLIPs, and a ubiquitin-removing enzyme called USP8 ..
  8. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2011
    ..in vivo and in vitro model systems, we recently obtained preliminary data suggesting that the E3 ubiquitin ligase Itch plays an important role in the TGF-2-induced expression of Foxp3 and Treg- mediated proliferative inhibition...
  9. Mechanisms of protein ubiquitination in regulating airway inflammation
    Yun Cai Liu; Fiscal Year: 2010
    ..in vivo and in vitro model systems, we recently obtained preliminary data suggesting that the E3 ubiquitin ligase Itch plays an important role in the TGF-2-induced expression of Foxp3 and Treg- mediated proliferative inhibition...
  10. Manipulation of T cell tolerance with small organic mol*
    Anjana Rao; Fiscal Year: 2005
    ..that induce or inhibit T cell anergy by targeting the transcription factor NFAT and the E3 ubiquitin ligase Itch, respectively...
  11. Neural Mechanisms of Itch
    Earl E Carstens; Fiscal Year: 2010
    b>Itch is an unpleasant sensation associated with the desire to scratch...
  12. Transmitter release from peripheral sensory neurons
    AMY MACDERMOTT; Fiscal Year: 2009
    The peripheral sensory nerves specialized for detection of noxious stimuli, temperature and itch have their peripheral terminals in the skin, muscle, bone and viscera, their cell bodies in the dorsal root ganglion (DRG), and their central ..
  13. Transmitter release from peripheral sensory neurons
    AMY MACDERMOTT; Fiscal Year: 2007
    The peripheral sensory nerves specialized for detection of noxious stimuli, temperature and itch have their peripheral terminals in the skin, muscle, bone and viscera, their cell bodies in the dorsal root ganglion (DRG), and their ..
  14. Transmitter release from peripheral sensory neurons
    Amy B Macdermott; Fiscal Year: 2010
    The peripheral sensory nerves specialized for detection of noxious stimuli, temperature and itch have their peripheral terminals in the skin, muscle, bone and viscera, their cell bodies in the dorsal root ganglion (DRG), and their central ..
  15. EM STUDIES ON MUSCLE
    Kenneth Taylor; Fiscal Year: 2007
    ..activated contraction are emphasized and complemented by states stabilized with nucleotide analogues such as ADP-AIF4 and ADP-Vanadate +/- Ca2+...
  16. Behavioral Pharmacology of Itch
    Mei Chuan Ko; Fiscal Year: 2010
    Pruritus (itch sensation) is a symptom derived from many nervous system disorders that afflicts a large population of humans and is treated by a variety of pharmacological agents with variable success...
  17. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward Harhaj; Fiscal Year: 2009
    ..Furthermore, we have found that TAX1BP1 recruits the HECT E3 ligase Itch to A20 via two PPXY motifs...
  18. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2010
    ..Furthermore, we have found that TAX1BP1 recruits the HECT E3 ligase Itch to A20 via two PPXY motifs...
  19. MYOFIBRILLAR STRUCTURE OF STRIATED MUSCLE
    Michael Reedy; Fiscal Year: 2006
    ..pre-powerstroke) active bridges, to be favored at high [Ca2+]by cooling, high [Pi], and Pi analogs (BDM, vanadate, AIF4", BeFx), will be compared with high-force bridges using X-ray, 3D-EM and fitting of atomic models...
  20. NEUROPHYSIOLOGY OF PAIN ADAPTATION AND HYPERALGESIA
    ROBERT LA MOTTE; Fiscal Year: 1991
    ..the role of nociceptive neurons in the peripheral and central nervous system in mediating cutaneous pain, itch and hyperalgesia...
  21. Inflammatory influence on mechanoreceptor response
    ROBERT TUCKETT; Fiscal Year: 2007
    ..According to this view, the cutaneous sensory modalities of touch, pain, temperature (warmth, cooling) and itch are encoded by specific classes of peripheral neurons and are transmitted by particular central nervous system ..
  22. lung tumor exosome-mediated inflammation promotes tumor progression and growth
    Huang Ge Zhang; Fiscal Year: 2009
    ..We have now identified two exosomal proteins that interact with TRAF2, Itch and Jabi, which have the potential to enhance the ubiquitination of CYLD in lung tumor cells...
  23. lung tumor exosome-mediated inflammation promotes tumor progression and growth
    Huang Ge Zhang; Fiscal Year: 2010
    ..We have now identified two exosomal proteins that interact with TRAF2, Itch and Jabi, which have the potential to enhance the ubiquitination of CYLD in lung tumor cells...