Gene Symbol: ISL1
Description: ISL LIM homeobox 1
Alias: ISLET1, Isl-1, insulin gene enhancer protein ISL-1, ISL1 transcription factor, LIM/homeodomain, islet-1
Species: human
Products:     ISL1

Top Publications

  1. Peng S, Wang W, Meng J, Li T, Zhang H, Li Y, et al. ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells. Biochim Biophys Acta. 2005;1731:154-9 pubmed
    b>ISL1 is a LIM homeodomain protein that plays an important role in insulin gene transcriptional activation and islet cell formation...
  2. Holm P, Rydlander B, Luthman H, Kockum I. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Diabetes. 2004;53:1584-91 pubmed
    We have previously reported suggestive linkage to chromosome 5p13-q13 in type 1 diabetic families. ISL1, a transcription factor involved in pancreas development, maps to this region...
  3. Stevens K, Hakonarson H, Kim C, Doevendans P, Koeleman B, Mital S, et al. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PLoS ONE. 2010;5:e10855 pubmed publisher
    ..b>ISLET1 (ISL1) is a transcription factor that marks cardiac progenitor cells and generates diverse multipotent ..
  4. Takeuchi J, Mileikovskaia M, Koshiba Takeuchi K, Heidt A, Mori A, Arruda E, et al. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005;132:2463-74 pubmed
    ..The Mef2c AHF enhancer relies on Isl1- and Gata-binding sites...
  5. Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai C, et al. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A. 2007;104:9313-8 pubmed
    Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart ..
  6. Graham R, Shrestha B, Caron B, Smyrk T, Grogg K, Lloyd R, et al. Islet-1 is a sensitive but not entirely specific marker for pancreatic neuroendocrine neoplasms and their metastases. Am J Surg Pathol. 2013;37:399-405 pubmed publisher
    Islet-1 (Isl1) is a transcription factor involved in the embryogenesis of islets of Langerhans. Immunohistochemically, Isl1 is a sensitive lineage-specific marker for pancreatic neuroendocrine neoplasms (NENs) and their metastases...
  7. Luo Z, Sun H, Yang Z, Ma Y, Gu Y, He Y, et al. Genetic variations of ISL1 associated with human congenital heart disease in Chinese Han people. Genet Mol Res. 2014;13:1329-38 pubmed publisher
    Congenital heart disease (CHD) is the most common birth abnormality, but the etiology of CHD is unknown. ISL1 may play a fundamental role in cardiac morphogenesis, and mutations of this gene could cause CHD...
  8. Pfaff S, Mendelsohn M, Stewart C, Edlund T, Jessell T. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996;84:309-20 pubmed
    Motor neuron differentiation is accompanied by the expression of a LIM homeodomain transcription factor, Islet1 (ISL1)...
  9. Ahlgren U, Pfaff S, Jessell T, Edlund T, Edlund H. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature. 1997;385:257-60 pubmed
    ..The LIM homeodomain protein ISL1 is expressed in all classes of islet cells in the adult and its expression in the embryo is initiated soon after ..

More Information

Publications129 found, 100 shown here

  1. Bu L, Jiang X, Martin Puig S, Caron L, Zhu S, Shao Y, et al. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009;460:113-7 pubmed publisher
    ..Here we identify a diverse set of human fetal ISL1(+) cardiovascular progenitors that give rise to the cardiomyocyte, smooth muscle and endothelial cell lineages...
  2. Zhang H, Wang W, Guo T, Yang J, Chen P, Ma K, et al. The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2. J Mol Biol. 2009;392:566-77 pubmed publisher
    The LIM-homeodomain transcription factor ISL1 (islet factor 1) is essential for pancreatic islet cell and dorsal mesenchyme development. Mutations in ISL1 are associated with maturity-onset diabetes of the young and type 2 diabetes...
  3. Genead R, Danielsson C, Wärdell E, Kjaeldgaard A, Westgren M, Sundström E, et al. Early first trimester human embryonic cardiac Islet-1 progenitor cells and cardiomyocytes: Immunohistochemical and electrophysiological characterization. Stem Cell Res. 2010;4:69-76 pubmed publisher
    ..this study were to systematically characterize the distribution, proliferation, and differentiation of Islet-1(+)(Isl1(+)) progenitor cells in the early first trimester human embryonic heart during which period most of the ..
  4. Stefan M, Simmons R, Bertera S, Trucco M, Esni F, Drain P, et al. Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab. 2011;300:E909-22 pubmed publisher
    ..In TgPWS pancreas, mRNA levels for genes encoding all pancreatic hormones, other secretory factors, and the ISL1 transcription factor are upregulated by either a compensatory response to plasma hormone deficiencies or a primary ..
  5. Sumitha R, Manjunatha V, Sabitha R, Alladi P, Nalini A, Rao L, et al. Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells. Mol Neurobiol. 2019;56:1014-1034 pubmed publisher
    ..In this study, human embryonic stem cells-BJNHem20-were differentiated into motor neurons expressing HB9, Islet1, and choline acetyl transferase using retinoic acid and purmorphamine...
  6. Yun Y, Zhang Y, Li G, Chen S, Sang N. Embryonic exposure to oxy-polycyclic aromatic hydrocarbon interfere with pancreatic β-cell development in zebrafish via altering DNA methylation and gene expression. Sci Total Environ. 2019;660:1602-1609 pubmed publisher
    ..with glucose metabolism, and altered the expression of pancreatic organogenesis-related genes pdx-1, foxa2, isl1 and ptf1a...
  7. Sato S, Yajima H, Furuta Y, Ikeda K, Kawakami K. Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS ONE. 2015;10:e0136666 pubmed publisher
    ..Cre-mediated recombination was detected specifically in ISL1/2-positive sensory neurons of Six1-positive cranial sensory ganglia and DRG...
  8. Ji X, Zhang Y, Ku T, Yun Y, Li G, Sang N. MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO2, NO2 and PM2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway. Toxicol Res (Camb). 2016;5:1548-1560 pubmed publisher
    ..This study provides evidence for the role of miRNAs in PH through targeting HIF-1α/Fhl-1 pathway after air pollutants co-exposure and implies new insights into the molecular markers for COPD caused by air pollution. ..
  9. Gallo R, Natale M, Vendrame F, Boggi U, Filipponi F, Marchetti P, et al. In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells. Acta Diabetol. 2012;49 Suppl 1:S123-31 pubmed publisher
    ..the induction of apoptosis, the glucose-stimulated insulin secretion, and the expression of β-cell function genes (Isl1, Pax6, Glut-2, glucokinase) and apoptosis-related genes (Bax and Bcl2)...
  10. Connell J, Ruano R, Jacot J. Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway. Biomed Mater. 2015;10:034103 pubmed publisher
  11. Mohseni R, Ashrafi M, Ai J, Nikougoftar M, Mohammadi M, Ghahvechi Akbari M, et al. Overexpression of SMN2 Gene in Motoneuron-Like Cells Differentiated from Adipose-Derived Mesenchymal Stem Cells by Ponasterone A. J Mol Neurosci. 2019;67:247-257 pubmed publisher
    ..05), as confirmed by the Western blot analysis. The PNA treatment increased the levels of ChAT, Isl1, Hb9, and Nkx2 expression in MN-like cells...
  12. Chaurasia S, Deswal R. Identification and In Silico Analysis of Major Redox Modulated Proteins from Brassica juncea Seedlings Using 2D Redox SDS PAGE (2-Dimensional Diagonal Redox Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis). Protein J. 2017;36:64-76 pubmed publisher
    ..This simple procedure can be used to detect major stress mediated redox changes in other plants. ..
  13. Wang H, Zhao S, Barton M, Rosengart T, Cooney A. Reciprocity of Action of Increasing Oct4 and Repressing p53 in Transdifferentiation of Mouse Embryonic Fibroblasts into Cardiac Myocytes. Cell Reprogram. 2018;20:27-37 pubmed publisher
    ..We found that overexpression of Oct4 significantly enhanced Mesp1, Tbx5, and Isl1 expression in p53+/+ and p53+/- MEFs...
  14. Cheng Y, Yeih D, Liang S, Chien C, Yu Y, Ko B, et al. Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells. Int J Cardiol. 2015;201:441-8 pubmed publisher
  15. Gergics P, Christian H, Choo M, Ajmal A, Camper S. Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation. Endocrinology. 2016;157:3631-46 pubmed publisher
    ..have elevated expression of transcription factors that are important in thyrotrope function, such as Gata2 and Islet 1, and those that stimulate proliferation, including Nupr1, E2f1, and Etv5...
  16. Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom J, Kume T. Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes. Stem Cells. 2016;34:1487-500 pubmed publisher
    ..and overexpression ESC models reveals a close relationship between Foxc1 levels and early cardiomyogenic factors Isl1, Mef2c, and Nkx2.5 and also the production of functional cardiomyocytes...
  17. Gurung P, Barnett A, Wilson J, Hudson J, Ward D, Messing E, et al. Prognostic DNA Methylation Biomarkers in High-risk Non-muscle-invasive Bladder Cancer: A Systematic Review to Identify Loci for Prospective Validation. Eur Urol Focus. 2019;: pubmed publisher
    ..8 for OS), Runt domain transcription factor 3 (RUNX3; HR: 5.1 for TP), Homeobox 9 (HOXA9; HR: 1.9 for TR), Islet-1 (ISL1; HRs: 1.7 for TR, 3.3 for TP), and PAX6 (HR: 2.2 for TR)...
  18. Li H, Zuo S, Pasha Z, Yu B, He Z, Wang Y, et al. GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4. Cytotherapy. 2011;13:1057-65 pubmed publisher
    ..Overexpression of GATA-4 significantly increases MSC differentiation into a myocardial phenotype, which might be associated with the up-regulation of IGFBP-4. ..
  19. Zaal A, Nota B, Moore K, Dieker M, Van Ham S, ten Brinke A. TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3K?, SGK1, and FOXO transcription factors. J Leukoc Biol. 2017;102:1035-1054 pubmed publisher
    ..Our findings shed new light on the depth and complexity of C5aR and TLR4 crosstalk and provide new foci of research for future studies. ..
  20. Stoyek M, Croll R, Smith F. Intrinsic and extrinsic innervation of the heart in zebrafish (Danio rerio). J Comp Neurol. 2015;523:1683-700 pubmed publisher
    ..for hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and the transcription factor Islet-1 (Isl1)...
  21. Lee M, Kundu J, Chae J, Shim J. Targeting ROCK/LIMK/cofilin signaling pathway in cancer. Arch Pharm Res. 2019;: pubmed publisher
    ..In this review, we will discuss comprehensive ROCK/LIMK/cofilin signaling pathway in cancers and its inhibitors for developing cancer therapy. ..
  22. Srivastava V, Verma P. Genome Wide Identification of LIM Genes in Cicer arietinum and Response of Ca-2LIMs in Development, Hormone and Pathogenic Stress. PLoS ONE. 2015;10:e0138719 pubmed publisher
    The eukaryotic lineage-specific LIM protein (LIN11, ISL1, and MEC3) family play pivotal role in modulation of actin dynamics and transcriptional regulation...
  23. Smirnov A, Lena A, Cappello A, Panatta E, Anemona L, Bischetti S, et al. ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development. Oncogene. 2019;38:1625-1638 pubmed publisher
    ..Together, these studies reinforce that p63 is a crucial gene for maintaining epithelial tissue integrity and support the deregulation of the cell-cell adhesion programme,which plays a critical role in carcinoma development. ..
  24. Cunha G, Kurita T, Cao M, Shen J, Robboy S, Baskin L. Molecular mechanisms of development of the human fetal female reproductive tract. Differentiation. 2017;97:54-72 pubmed publisher
    ..Mesenchymal differentiation was examined through immunostaining for HOXA11 (expressed in uterine mesenchyme) and ISL1 (expressed in vaginal mesenchyme)...
  25. Meseguer S, Panadero J, Navarro González C, Villarroya M, Boutoual R, Comi G, et al. The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3022-3037 pubmed publisher
    ..We show that miR-218-5p and miR-4775 are direct regulators of fetal cardiac genes such as NODAL, RHOA, ISL1 and RXRB, which are up-regulated in MELAS cybrids and in patient muscle samples with heteroplasmy above 60%...
  26. Gupta M, De Jesus D, Kahraman S, Valdez I, Shamsi F, Yi L, et al. Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Mol Metab. 2018;18:153-163 pubmed publisher
    ..a decrease in adipocyte (Fas, Acc, Pparγ, Fabp4, C/ebpα, and Fsp27) and pancreatic beta cell markers (Ngn3, Isl1, and Sox9)...
  27. Emerson S, Nguyen H, Torian U, Mather K, Firth A. An essential RNA element resides in a central region of hepatitis E virus ORF2. J Gen Virol. 2013;94:1468-76 pubmed publisher
    ..The RNA element is predicted to fold into two highly conserved stem-loop structures, ISL1 and ISL2...
  28. Abbasi N, Hashemi S, Salehi M, Jahani H, Mowla S, Soleimani M, et al. Influence of oriented nanofibrous PCL scaffolds on quantitative gene expression during neural differentiation of mouse embryonic stem cells. J Biomed Mater Res A. 2016;104:155-64 pubmed publisher
    ..Analysis also showed higher expression of dorso-ventral neural markers (Isl1/2 and Lim1/2) than motor neuron progenitor markers (Pax6, Nkx6...
  29. Lizio M, Ishizu Y, Itoh M, Lassmann T, Hasegawa A, Kubosaki A, et al. Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line. Front Genet. 2015;6:331 pubmed publisher
    ..The data confirm NEUROD1 as a key positive regulator in the transcriptional regulatory network (TRN), and ISL1, and PROX1 as antagonists...
  30. Hatzistergos K, Jiang Z, Valasaki K, Takeuchi L, Balkan W, Atluri P, et al. Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells. Stem Cells Dev. 2018;: pubmed publisher
  31. Shen E, Jiang Y, Javidfar B, Kassim B, Loh Y, Ma Q, et al. Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety. Neuropsychopharmacology. 2016;41:3103-3113 pubmed publisher
    ..Consistent with the role of Kmt2a in promoting gene expression, the transcriptional regulators Bahcc1, Isl1, and Sp9 were downregulated and affected by H3K4 promoter hypomethylation...
  32. Richards P, Pais R, Habib A, Brighton C, Yeo G, Reimann F, et al. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides. 2016;77:21-7 pubmed publisher
    ..sensing machinery (Slc5a1, Slc15a1, Abcc8, Gpr120) and enteroendocrine-specific transcription factors (Etv1, Isl1, Mlxipl, Nkx2.2 and Rfx6)...
  33. Hou J, Long H, Zhou C, Zheng S, Wu H, Guo T, et al. Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro. Stem Cell Res Ther. 2017;8:4 pubmed publisher
    ..It might function via enhancing the expressions of cardiac-specific transcription factors and EMT-associated genes. Mesp1 could be a pivotal intermediary in the procedure. ..
  34. Bejarano Escobar R, Álvarez Hernán G, Morona R, González A, Martín Partido G, Francisco Morcillo J. Expression and function of the LIM-homeodomain transcription factor Islet-1 in the developing and mature vertebrate retina. Exp Eye Res. 2015;138:22-31 pubmed publisher
    The LIM-homeodomain transcription factor Islet-1 (Isl1) has been widely used as a marker of different subtypes of neurons in the developing and mature retina of vertebrates...
  35. Song L, Wang K, Li Y, Yang Y. Nanotopography promoted neuronal differentiation of human induced pluripotent stem cells. Colloids Surf B Biointerfaces. 2016;148:49-58 pubmed publisher
    ..This study contributes to the delineation of cell-nanotopography interactions and provides the insights into the design of nanotopography configuration for pluripotent stem cell neural lineage commitment. ..
  36. Bagher Z, Ebrahimi Barough S, Azami M, Mirzadeh H, Soleimani M, Ai J, et al. Induction of human umbilical Wharton's jelly-derived mesenchymal stem cells toward motor neuron-like cells. In Vitro Cell Dev Biol Anim. 2015;51:987-94 pubmed publisher
    ..neurons were then characterized for expression of motor neuron markers including nestin, PAX6, NF-H, Islet 1, HB9, and choline acetyl transferase (ChAT) by quantitative reverse transcription PCR and immunocytochemistry...
  37. Shen N, Qu Y, Yu Y, So K, Goffinet A, Vardi N, et al. Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells. Invest Ophthalmol Vis Sci. 2016;57:2788-96 pubmed publisher
    ..Frizzled3 was conditionally removed from the retina of Isl1-Cre;Fzd3f/- mice using the Cre-loxP system...
  38. Weaver C, Miller S, da Fontoura C, Wehby G, Amendt B, Holton N, et al. Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion. Am J Orthod Dentofacial Orthop. 2017;151:539-558 pubmed publisher
    ..Suggestive associations (P < 0.05) were identified with PITX2, SNAI3, 11q22.2-q22.3, 4p16.1, ISL1, and FGF8...
  39. Velasquez Mao A, Tsao C, Monroe M, Legras X, Bissig Choisat B, Bissig K, et al. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS ONE. 2017;12:e0177824 pubmed publisher
    ..These results demonstrate that cells from human amniotic fluid can be differentiated through a pluripotent state into functional cardiomyocytes. ..
  40. Shirian S, Ebrahimi Barough S, Saberi H, Norouzi Javidan A, Mousavi S, Derakhshan M, et al. Comparison of Capability of Human Bone Marrow Mesenchymal Stem Cells and Endometrial Stem Cells to Differentiate into Motor Neurons on Electrospun Poly(ε-caprolactone) Scaffold. Mol Neurobiol. 2016;53:5278-87 pubmed publisher
    ..Both cells may be potential candidates for cellular therapy in motor neuron disorders. However, differentiation of hEnSCs into motor neuron-like cells was better than hBM-MSCs. ..
  41. Galloway J, Bethea M, Liu Y, Underwood R, Mobley J, Hunter C. SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes. Mol Endocrinol. 2015;29:1774-86 pubmed publisher
    Islet-1 (Isl1) is a Lin11, Isl1, Mec3 (LIM)-homeodomain transcription factor important for pancreatic islet cell development, maturation, and function, which largely requires interaction with the LIM domain-binding protein 1 (Ldb1) ..
  42. Shimojo D, Onodera K, Doi Torii Y, Ishihara Y, Hattori C, Miwa Y, et al. Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells. Mol Brain. 2015;8:79 pubmed publisher
    ..Our motor neuron differentiation system and lentivirus-based reporter system for motor neurons facilitate the analysis of disease-specific hiPSCs for motor neuron diseases. ..
  43. Rhee H, Closser M, Guo Y, Bashkirova E, Tan G, Gifford D, et al. Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers. Neuron. 2016;92:1252-1265 pubmed publisher
    ..spinal motor neuron identity is established by cooperative binding of programming transcription factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers...
  44. Beati H, Peek I, Hordowska P, Honemann Capito M, Glashauser J, Renschler F, et al. The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. J Cell Biol. 2018;217:1079-1095 pubmed publisher
    ..Overexpression of Smash causes apical constriction of epithelial cells. We propose that Smash is a key regulator of morphogenesis coordinating PCP and actomyosin contractility at the ZA. ..
  45. Erlenbach Wünsch K, Haller F, Taubert H, Wurl P, Hartmann A, Agaimy A. Expression of the LIM homeobox domain transcription factor ISL1 (Islet-1) is frequent in rhabdomyosarcoma but very limited in other soft tissue sarcoma types. Pathology. 2014;46:289-95 pubmed publisher
    The transcription factor ISL1 (islet-1) has emerged as a useful marker for metastatic pancreatic well differentiated neuroendocrine neoplasms, but recent studies showed wider expression in poorly differentiated neuroendocrine carcinomas ..
  46. Bahrami N, Bayat M, Mohamadnia A, Khakbiz M, Yazdankhah M, Ai J, et al. Purmorphamine as a Shh Signaling Activator Small Molecule Promotes Motor Neuron Differentiation of Mesenchymal Stem Cells Cultured on Nanofibrous PCL Scaffold. Mol Neurobiol. 2017;54:5668-5675 pubmed publisher for 15 days, the cells were characterized for expression of motor neuron markers including PAX6, NF-H, Islet1, HB9, and choline acetyl transferase (ChAT) by quantitative reverse transcription (PCR) and immunocytochemistry...
  47. Velayos T, Martinez R, Alonso M, Garcia Etxebarria K, Aguayo A, Camarero C, et al. An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis. Diabetes. 2017;66:1022-1029 pubmed publisher
    ..These findings represent the first functional indication of a direct link between an NDM-linked activating mutation in STAT3 and pancreatic ?-cell dysfunction. ..
  48. Colombo S, de Sena Tomás C, George V, Werdich A, Kapur S, Macrae C, et al. Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression. Development. 2018;145: pubmed publisher
    ..tract, delimit the number of pSHF progenitors at the venous pole and pattern the sinoatrial node acting through Isl1 repression...
  49. Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, et al. Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Stem Cells Dev. 2015;24:2193-205 pubmed publisher
    ..Among these are several that are important in cardiac development and contractility such as Plagl1, Isl1, and Tnnt2...
  50. Thiebes K, Nam H, Cambronne X, Shen R, Glasgow S, Cho H, et al. miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nat Commun. 2015;6:7718 pubmed publisher
    ..Here we show that in the developing spinal cord, the expression of miR-218 is directly upregulated by the Isl1-Lhx3 complex, which drives motor neuron fate...
  51. Gage B, Asadi A, Baker R, Webber T, Wang R, Itoh M, et al. The Role of ARX in Human Pancreatic Endocrine Specification. PLoS ONE. 2015;10:e0144100 pubmed publisher
    ..Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2...
  52. Rebman J, Kirchoff K, Walsh G. Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons. PLoS ONE. 2016;11:e0164433 pubmed publisher
    ..We generated stable transgenic zebrafish expressing dominant-negative Cadherin-2 (Cdh2ΔEC) driven by the islet1 promoter...
  53. Chen S, Chen J, Meng X, Shen J, Huang J, Huang P, et al. ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells. Oncotarget. 2016;7:80391-80403 pubmed publisher
    ..The observed myocardial regeneration accompanying reversal of adriamycin cardiomyopathy was associated with upregulation of PirB expression on the cell membrane of cardiac muscle cells or progenitor cells stimulated by ANGPTL8. ..
  54. Dvorakova M, Jahan I, Macova I, Chumak T, Bohuslavova R, Syka J, et al. Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance. Sci Rep. 2016;6:38253 pubmed publisher
    The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type ..
  55. Michalak S, Whitman M, Park J, Tischfield M, Nguyen E, Engle E. Ocular Motor Nerve Development in the Presence and Absence of Extraocular Muscle. Invest Ophthalmol Vis Sci. 2017;58:2388-2396 pubmed publisher
    ..E11.5 and E18.5 brainstems were serially sectioned and stained for Islet1 to determine the fate of ocular motor neurons. At E11...
  56. Falgairolle M, Puhl J, Pujala A, Liu W, O Donovan M. Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse. elife. 2017;6: pubmed publisher
    ..ChR2) in Choline acetyltransferase neurons (ChAT+) or Arch in LIM-homeodomain transcription factor Isl1+ neurons...
  57. Bhati M, Llamosas E, Jacques D, Jeffries C, Dastmalchi S, Ripin N, et al. Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans. Sci Rep. 2017;7:4579 pubmed publisher
    ..In chick and mammals the interaction between two LIM-HD proteins, LHX3 and Islet1 (ISL1), is essential for the development of motor neurons...
  58. Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, et al. Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy. Stem Cell Reports. 2018;10:848-859 pubmed publisher
    The LIM-homeodomain transcription factor ISL1 marks multipotent cardiac progenitors that give rise to cardiac muscle, endothelium, and smooth muscle cells...
  59. Nguyen K, Hall A, Jones J. Expression of myosin VIIA in the developing chick inner ear neurons. Gene Expr Patterns. 2015;19:36-44 pubmed publisher
    ..The present study characterized the expression of myosin VIIA, along with the neuronal markers, Islet1, NeuroD1 and TuJ1, in the developing avian ear, during Hamburger-Hamilton (HH) stages 16-40...
  60. Gopalakrishnan S, Comai G, Sambasivan R, Francou A, Kelly R, Tajbakhsh S. A Cranial Mesoderm Origin for Esophagus Striated Muscles. Dev Cell. 2015;34:694-704 pubmed publisher
    ..Tbx1 and Isl1 act as key regulators of ESMs, which we now identify as a third derivative of cardiopharyngeal mesoderm that ..
  61. Stil A, Drapeau P. Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish. Dev Neurobiol. 2016;76:642-60 pubmed publisher
    ..transgenic lines in which expression of green fluorescent protein (GFP) is driven by promoters to hb9 and isl1 in motoneurons, alx/chx10 and evx1 interneurons, ngn1 in sensory neurons and olig2 in oligodendrocytes, as well as ..
  62. Li F, Li Z, Jiang Z, Tian Y, Wang Z, Yi W, et al. Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res. 2016;8:4791-4801 pubmed
    ..the viability of DFAT cells, but stimulated the cells to express early cardiac transcription factors including Islet1, Nkx2...
  63. Huang L, Chen M, Zhang W, Sun X, Liu B, Ge J. Retinoid acid and taurine promote NeuroD1-induced differentiation of induced pluripotent stem cells into retinal ganglion cells. Mol Cell Biochem. 2018;438:67-76 pubmed publisher
    ..However, RA and taurine did not promote differentiation in the absence of NeuroD1 overexpression. Together, our study provides new evidence in transcription factor-regulated stem cell differentiation in vitro. ..
  64. Caputo L, Witzel H, Kolovos P, Cheedipudi S, Looso M, Mylona A, et al. The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell. 2015;17:287-99 pubmed publisher
    ..We demonstrate that Ldb1 binds to the key regulator of cardiac progenitors, Isl1, and protects it from degradation...
  65. Xu J, Lee Y, Ran X, Liao S, Yang J, Au K, et al. Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration. Stem Cells. 2016;34:2693-2706 pubmed publisher
    ..They resembled eCS, but contained a higher percentage of cells expressing Mesp1, Isl1, and Nkx2.5...
  66. Li F, Fu G, Liu Y, Miao X, Li Y, Yang X, et al. ISLET1-Dependent ?-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw. Mol Cell Biol. 2017;37: pubmed publisher
    ..Using ShhCre to target the mandibular epithelium, we ablated transcription factor Islet1, resulting in a distally truncated mandible via unbalanced cell apoptosis and decreased cell proliferation in ..
  67. Goto K, Imamura K, Komatsu K, Mitani K, Aiba K, Nakatsuji N, et al. Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors. Mol Ther Methods Clin Dev. 2017;4:115-125 pubmed publisher
    ..This simple approach significantly reduces the efforts required to generate MNs, and it provides a useful tool for disease modeling. ..
  68. Yi Q, Xu H, Yang K, Wang Y, Tan B, Tian J, et al. Islet-1 induces the differentiation of mesenchymal stem cells into cardiomyocyte-like cells through the regulation of Gcn5 and DNMT-1. Mol Med Rep. 2017;15:2511-2520 pubmed publisher
  69. Valizadeh Arshad Z, Shahbazi E, Hashemizadeh S, Moradmand A, Jangkhah M, Kiani S. In Vitro Differentiation of Neural-Like Cells from Human Embryonic Stem Cells by A Combination of Dorsomorphin, XAV939, and A8301. Cell J. 2018;19:545-551 pubmed publisher
    ..The replated (hESC)-derived NE differentiated cells were positive for TUJ1, MAP2, HB9 and ISL1. We evaluated the gene expression levels with real-time reverse transcriptase-PCR at different stages of the ..
  70. Burkhard S, van Eif V, Garric L, Christoffels V, Bakkers J. On the Evolution of the Cardiac Pacemaker. J Cardiovasc Dev Dis. 2017;4: pubmed publisher
    ..Special focus is given to pacemaker development in zebrafish, an extensively used model for vertebrate development. Finally, we conclude with a summary of highly conserved key factors in pacemaker cell development and function. ..
  71. Lang J, Tian W, Sun X. Association between ISL1 variants and susceptibility to ventricular septal defect in a Chinese cohort. Mol Diagn Ther. 2013;17:101-6 pubmed publisher
    It has previously been reported that ISLET1 (ISL1) plays a fundamental role in cardiac morphogenesis...
  72. Koh Y, Park I, Sun C, Lee S, Yun H, Park C, et al. Detection of a Distinctive Genomic Signature in Rhabdoid Glioblastoma, A Rare Disease Entity Identified by Whole Exome Sequencing and Whole Transcriptome Sequencing. Transl Oncol. 2015;8:279-87 pubmed publisher
    ..We identified the BRAF V600E mutation and possible functional changes in the mutated genes, ISL1 and NDRG2. Copy number alteration analysis revealed gains of chromosomes 3, 7, and 9...
  73. Waclaw R, Ehrman L, Merchan Sala P, Kohli V, Nardini D, Campbell K. Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon. Mol Cell Neurosci. 2017;80:44-51 pubmed publisher
    Recent studies have shown that the LIM-homeodomain transcription factor Isl1 is required for the survival and differentiation of direct pathway striatonigral neurons during embryonic development...
  74. Dong J, Asa S, Drucker D. Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1. Mol Endocrinol. 1991;5:1633-41 pubmed
    ..The results of these studies implicate a potential role for isl-1 outside the endocrine pancreas in the nervous system and kidney. ..
  75. Gay F, Anglade I, Gong Z, Salbert G. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol Endocrinol. 2000;14:1627-48 pubmed
    ..Among LIM/HD proteins, Islet-1 (ISL1) is the earliest known marker of motoneuron differentiation and has been extensively studied in this context...
  76. Dorn T, Goedel A, Lam J, Haas J, Tian Q, Herrmann F, et al. Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity. Stem Cells. 2015;33:1113-29 pubmed publisher
    During cardiogenesis, most myocytes arise from cardiac progenitors expressing the transcription factors Isl1 and Nkx2-5...
  77. Abernathy D, Kim W, McCoy M, Lake A, Ouwenga R, Lee S, et al. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell Stem Cell. 2017;21:332-348.e9 pubmed publisher
    ..Consistently, we show that ISL1 and LHX3 selectively drive conversion to a highly homogeneous population of human spinal cord motor neurons...
  78. Riggs A, Tanizawa Y, Aoki M, Wasson J, Ferrer J, Rabin D, et al. Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM. Diabetes. 1995;44:689-94 pubmed
    ..Exons 2 and 3 each encode a LIM domain, while the homeodomain is completely contained within exon 4.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  79. Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, et al. Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Diabetes. 2006;55:2379-86 pubmed
    ..We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6...
  80. Ferrara A, Rossi G, Zampella E, Di Candia S, Pagliara V, Nettore I, et al. Screening for mutations in the ISL1 gene in patients with thyroid dysgenesis. J Endocrinol Invest. 2011;34:e149-52 pubmed publisher
    ..Among these, it can be included Isl1, a transcription factor containing a LIM homeodomain that is expressed in both thyroid and heart during ..
  81. Zhang Q, Yang Z, Wang W, Guo T, Jia Z, Ma K, et al. A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic ?-cells. Biochem Biophys Res Commun. 2014;449:295-300 pubmed publisher
    ..Taken together, our results demonstrate a positive feedback regulation of ISL-1 in DLBCL but not in pancreatic ?-cells, which might result in the functional diversities of ISL-1 in different physiological and pathological processes. ..
  82. Hori Y, Gu X, Xie X, Kim S. Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med. 2005;2:e103 pubmed
  83. Xue L, Wang X, Xu J, Xu X, Liu X, Hu Z, et al. ISL1 common variant rs1017 is not associated with susceptibility to congenital heart disease in a Chinese population. Genet Test Mol Biomarkers. 2012;16:679-83 pubmed publisher
    b>ISL1, as a member of the LIM homeodomain transcription factor family, is expressed in a distinct population of undifferentiated cardiac progenitors and plays a pivotal role in cardiogenesis...
  84. Friedrich F, Dilanian G, Khattar P, Juhr D, Gueneau L, Charron P, et al. A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity. Eur J Heart Fail. 2013;15:267-76 pubmed publisher
    The transcription factor Islet-1 (ISL1) is a marker of cardiovascular progenitors and is essential for mammalian cardiogenesis. An ISL1 haplotype has recently been associated with congenital heart disease...
  85. Liu J, Li W, Wang Y, Fan W, Li P, Lin W, et al. Islet-1 overexpression in human mesenchymal stem cells promotes vascularization through monocyte chemoattractant protein-3. Stem Cells. 2014;32:1843-54 pubmed publisher
    The LIM-homeobox transcription factor islet-1 (ISL1) has been proposed to mark a cardiovascular progenitor cell lineage that gives rise to cardiomyocytes, endothelial cells, and smooth muscle cells...
  86. Zhou Y, Park S, Su J, Bailey K, Ottosson Laakso E, Shcherbina L, et al. TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet. 2014;23:6419-31 pubmed publisher
    ..b>ISL1 is a primary target of TCF7L2 and regulates proinsulin production and processing via MAFA, PDX1, NKX6...
  87. Godamudunage M, Foster A, Warren D, Lyons B. Grb7 protein RA domain oligomerization. J Mol Recognit. 2017;30: pubmed publisher
    ..We report the Grb7RA domain can exist in transient multimeric forms and, based upon modeling results, postulate the potential role of Grb7RA domain oligomerization in Grb7 function. ..
  88. Blixt M, Konjusha D, Ring H, Hallböök F. The zinc finger gene Nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina. Dev Dyn. 2017;: pubmed publisher
    ..transcription factor Nolz1 regulates spinal cord neuron development by interacting with the transcription factors Isl1, Lim1 and Lim3, which are also important for photoreceptors, horizontal and bipolar cells during retinal ..
  89. Wang M, Drucker D. The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage. Endocrinology. 1994;134:1416-22 pubmed
    ..These experiments suggest that the biological importance of isl-1 may not be restricted to neuroendocrine cell lineages and raise the possibility that isl-1 function may be regulated by sequestration in distinct cellular compartments. ..
  90. Koo J, Zhou X, Moschiano E, de Peralta Venturina M, Mertens R, Dhall D. The immunohistochemical expression of islet 1 and PAX8 by rectal neuroendocrine tumors should be taken into account in the differential diagnosis of metastatic neuroendocrine tumors of unknown primary origin. Endocr Pathol. 2013;24:184-90 pubmed publisher
    ..Recently, rectal NETs have been noted to exhibit immunohistochemical (IHC) positivity for Islet 1 and PAX8, which are generally considered markers for NETs of pancreatic origin...
  91. Jung Y, Zhou R, Kato T, Usui J, Muratani M, Oishi H, et al. Isl1β Overexpression With Key β Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion. Endocrinology. 2018;159:869-882 pubmed publisher that an additional β cell developmental regulator, insulin gene enhancer binding protein splicing variant (Isl1β), improved insulin production and glucose-responsive secretion in PDA mice...
  92. Laurin N, Lee J, Ickowicz A, Pathare T, Malone M, Tannock R, et al. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:600-5 pubmed
    ..the genes for the glial cell-derived neurotropic factor (GDNF), the fibroblast growth factor 10 (FGF10), islet-1 (ISL1), the hyperpolarized potassium channel (HCN1) and the integrin alpha 1 (ITGA1)...