IRX3

Summary

Gene Symbol: IRX3
Description: iroquois homeobox 3
Alias: IRX-1, IRXB1, homeodomain protein IRXB1, iroquois homeobox protein 3, iroquois-class homeodomain protein IRX-1, iroquois-class homeodomain protein IRX-3
Species: human

Top Publications

  1. ncbi Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3
    Sonia Guidato
    MRC Centre for Developmental Neurobiology, 4th floor New Hunt s House, King s College, Guy s Campus, London SE1 1UL, UK
    Development 130:2981-96. 2003
  2. pmc Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus
    Ellen Robertshaw
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London SE1 1UL, United Kingdom
    Proc Natl Acad Sci U S A 110:E3919-26. 2013
  3. ncbi Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+ human cord blood cells
    Christina M Ferrell
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Stem Cells 23:644-55. 2005
  4. ncbi A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction
    Pascale Perry
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Cycle 3:1645-50. 2004
  5. ncbi Hedgehog signaling from the ZLI regulates diencephalic regional identity
    Clemens Kiecker
    MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt s House, Guy s Hospital Campus, King s College, London SE1 1UL, UK
    Nat Neurosci 7:1242-9. 2004
  6. ncbi The irregular xylem 2 mutant is an allele of korrigan that affects the secondary cell wall of Arabidopsis thaliana
    Pio M J Szyjanowicz
    School of Biological Sciences, University of Manchester, 3 614 Stopford Building, Manchester M13 9PT, UK
    Plant J 37:730-40. 2004
  7. ncbi Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain
    Michelle M Braun
    Program in Neurobiology and Behavior, Department of Biological Structure, Box 357420, University of Washington, Seattle, WA 98195, USA
    Development 130:5579-87. 2003
  8. ncbi A new cellulose synthase gene (PtrCesA2) from aspen xylem is orthologous to Arabidopsis AtCesA7 (irx3) gene associated with secondary cell wall synthesis
    Anita Samuga
    Plant Biotechnology Research Center, School of Forestry and Wood Products, Michigan Technological University, 1400 Townsend Drive, Houghton 49931, USA
    Gene 296:37-44. 2002
  9. ncbi Early subdivisions in the neural plate define distinct competence for inductive signals
    Daisuke Kobayashi
    Department of Neurobiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 129:83-93. 2002
  10. pmc Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology
    Nathalie Gaborit
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 139:4007-19. 2012

Scientific Experts

  • Paul Gifford
  • Diana Garcia-Cruz
  • V M Christoffels
  • Joan S Jorgensen
  • Zeng Quan Yang
  • Marco A Miranda
  • Masanori Takahashi
  • Eva Jimenez-Guri
  • Neil G Taylor
  • LEONARD ANDERSON
  • Nathalie Gaborit
  • SERGEI TEVOSIAN
  • Leonard M Anderson
  • BENOIT BRUNEAU
  • BENOIT GAETAN BRUNEAU
  • Sergei G Tevosian
  • Nancy K Roderer
  • Bongki Kim
  • Chi chung Hui
  • Shan Shan Zhang
  • Rui Sakuma
  • Ulrich Ruther
  • Elisa Rodríguez-Seguel
  • Pilar Alarcon
  • Clemens Kiecker
  • Ellen Robertshaw
  • Shundai Li
  • Nishal S Patel
  • Yong Bum Park
  • A Da Costa
  • Kyoung Han Kim
  • Benoit G Bruneau
  • John N Wylie
  • Ge Li
  • Youngha Kim
  • Jun An Chen
  • Sarah C Petersen
  • Hossein Salehi
  • Nienke Visser
  • Simon R Turner
  • Florence Naillat
  • Linda Holmquist Mengelbier
  • Anja Ragvin
  • Yun Kuan Liang
  • Sylvie Janssens
  • Theresa K Kelly
  • Jose Elias Garcia-Ortiz
  • Eun Kyung Lee
  • Wenjie He
  • Jose Luis Gomez-Skarmeta
  • Andrew Lumsden
  • Xue Jun Li
  • Suzanne Efron
  • Sheila M Bell
  • Ken Matsumoto
  • Qiong Gan
  • M Asejczyk-Widlicka
  • Luca Reggiani
  • Camilo Hernández-Blanco
  • Isabelle Anselme
  • Caiyun Yang
  • A C Houweling
  • J Mummenhoff
  • Shannon R Morey
  • Aurore Caqueret
  • Barbara Rosati
  • J M Ordway
  • David M Brown
  • Christina M Ferrell
  • Pio M J Szyjanowicz
  • Pascale Perry
  • Sonia Guidato
  • Michelle M Braun
  • Daisuke Kobayashi
  • Anita Samuga
  • Marie Ann Ha
  • Lei Lei
  • Christopher M Lee
  • Ying Gu
  • Claudia I Semprich
  • Kate G Storey
  • Pascal Dolle
  • Bon Wook Koo
  • Daniel J Cosgrove
  • Sunkyu Park
  • Seong H Kim
  • Pamela A Halley
  • Wendy A Bickmore
  • Muriel Rhinn
  • R Klopfleisch

Detail Information

Publications69

  1. ncbi Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3
    Sonia Guidato
    MRC Centre for Developmental Neurobiology, 4th floor New Hunt s House, King s College, Guy s Campus, London SE1 1UL, UK
    Development 130:2981-96. 2003
    ..motoneurones in ventral rhombomeres 1-4, and was accompanied by the repression of the dorsoventral patterning gene Irx3. Taken together, these observations suggest that the somites, retinoic acid and Hox genes play a role in patterning ..
  2. pmc Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus
    Ellen Robertshaw
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London SE1 1UL, United Kingdom
    Proc Natl Acad Sci U S A 110:E3919-26. 2013
    ..is established by the overlapping expression of two transcription factors: Iroquois-related homeobox gene 3 (Irx3) posterior to the ZLI, and paired box gene 6 (Pax6) anterior to the forebrain-midbrain boundary...
  3. ncbi Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+ human cord blood cells
    Christina M Ferrell
    Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Stem Cells 23:644-55. 2005
    ..Other validated genes included v-ets-related gene (ERG), Iroquois 3 (IRX3), aldehyde dehydrogenase 1 (ALDH1), and very long-chain acyl-CoA synthetase homolog 1 (VLCS-H1)...
  4. ncbi A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction
    Pascale Perry
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Cycle 3:1645-50. 2004
    ..In particular, we demonstrate that DNA replication at a subset of neural-associated genes including Pax3, Pax6, Irx3, Nkx2.9 and Mash1 is advanced upon neural induction, consistent with increased locus accessibility...
  5. ncbi Hedgehog signaling from the ZLI regulates diencephalic regional identity
    Clemens Kiecker
    MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt s House, Guy s Hospital Campus, King s College, London SE1 1UL, UK
    Nat Neurosci 7:1242-9. 2004
    ..of thalamic and prethalamic primordia in responding to Shh signaling is regulated by the transcription factor Irx3. We show that, through the release of Shh, the ZLI functions as a local signaling center that regulates the ..
  6. ncbi The irregular xylem 2 mutant is an allele of korrigan that affects the secondary cell wall of Arabidopsis thaliana
    Pio M J Szyjanowicz
    School of Biological Sciences, University of Manchester, 3 614 Stopford Building, Manchester M13 9PT, UK
    Plant J 37:730-40. 2004
    ..Co-precipitation experiments, using either an epitope-tagged form of KOR or IRX3 (AtCesA7), suggest that KOR is not an integral part of the cellulose synthase complex...
  7. ncbi Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain
    Michelle M Braun
    Program in Neurobiology and Behavior, Department of Biological Structure, Box 357420, University of Washington, Seattle, WA 98195, USA
    Development 130:5579-87. 2003
    ..manifestations of anteroposterior pattering in the developing brain is the restricted expression of Six3 and Irx3 in the anterior and posterior forebrain, respectively...
  8. ncbi A new cellulose synthase gene (PtrCesA2) from aspen xylem is orthologous to Arabidopsis AtCesA7 (irx3) gene associated with secondary cell wall synthesis
    Anita Samuga
    Plant Biotechnology Research Center, School of Forestry and Wood Products, Michigan Technological University, 1400 Townsend Drive, Houghton 49931, USA
    Gene 296:37-44. 2002
    ..Previously, a mutation in AtCesA7 gene (irx3) was correlated with a significant decrease in the amount of cellulose synthesized (about 70%) and genetic ..
  9. ncbi Early subdivisions in the neural plate define distinct competence for inductive signals
    Daisuke Kobayashi
    Department of Neurobiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 129:83-93. 2002
    ..Next we found that homeodomain transcription factors Six3 and Irx3 can alter the regional responses to both Fgf8 and Shh in the forebrain...
  10. pmc Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology
    Nathalie Gaborit
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 139:4007-19. 2012
    ..for certain postnatal cardiac functions, including cardiac repolarization (Irx5) and rapid ventricular conduction (Irx3). Irx genes are expressed in dynamic and partially overlapping patterns in the developing heart...
  11. doi Repeatability of internal aberrometry with a new simultaneous capture aberrometer/corneal topographer
    Paul Gifford
    School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia
    Optom Vis Sci 89:929-38. 2012
    ..CT) measured simultaneously by the Innovative Visual Systems Discovery, against time displaced but same instrument measurement (Nidek OPD-Scan 3), and time displaced different instrument measurement (Medmont E300 and Imagine Eyes irx3).
  12. pmc FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription
    Nishal S Patel
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS Genet 9:e1003614. 2013
    ..structured illumination microscopy, we show that chromatin around key differentiation gene loci Pax6 and Irx3 undergoes both decompaction and displacement towards the nuclear centre coincident with transcriptional onset...
  13. pmc Monitoring meso-scale ordering of cellulose in intact plant cell walls using sum frequency generation spectroscopy
    Yong Bum Park
    Departments of Biology, Pennsylvania State University, University Park, Pennsylvania 16802
    Plant Physiol 163:907-13. 2013
    ..SFG analysis of two cellulose synthase mutants (irx1/cesa8 and irx3/cesa7) indicates a reduction in cellulose content without evidence of altered cellulose structure...
  14. pmc Functional analysis of complexes with mixed primary and secondary cellulose synthases
    Shundai Li
    Department of Biochemistry and Molecular Biology The Center for LignoCellulose Structure and Formation Pennsylvania State University University Park, PA USA
    Plant Signal Behav 8:e23179. 2013
    ..at three of them cause the collapse of mature xylem cells in inflorescence stems of Arabidopsis (irx1(cesa8), irx3(cesa7) and irx5(cesa4)). These CESA genes are considered secondary cell wall CESAs...
  15. doi Identification of six potential markers for the detection of circulating canine mammary tumour cells in the peripheral blood identified by microarray analysis
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    J Comp Pathol 146:143-51. 2012
    ..Six mRNA markers, AGR2, ATP8B1, CRYAB, F3 IRX3 and SLC1A1 were expressed in cell lines, but not PBL...
  16. doi Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development
    Florence Naillat
    Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, Oulu Centre for Cell Matrix Research, Institute of Biomedicine, Biocenter Oulu, University of Oulu, PO Box 5000, FIN 90220 Oulu, Finland
    Hum Mol Genet 19:1539-50. 2010
    ..ovary, in fact, rescues the female property to a certain degree, as seen by inhibition of Cyp26b1 and induction of Irx3 gene expression...
  17. doi Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts
    Nathalie Gaborit
    INSERM, UMR915, l institut du thorax, Nantes, France
    J Mol Cell Cardiol 49:639-46. 2010
    ..Iroquois transcription factors (IRX3, IRX5) were more strongly expressed in female than male epicardium, but the transmural gradient remained...
  18. pmc Deletions of 16q in Wilms tumors localize to blastemal-anaplastic cells and are associated with reduced expression of the IRXB renal tubulogenesis gene cluster
    Linda Holmquist Mengelbier
    Department of Clinical Genetics, University and Regional Laboratories, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Am J Pathol 177:2609-21. 2010
    ..The smallest region of deletion overlap mapped to a 1.8-Mb segment containing the IRXB gene cluster including IRX3, IRX5, and IRX6, of which IRX3 is a recently identified regulator of tubular maturation during nephrogenesis...
  19. pmc Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
    Anja Ragvin
    Department of Clinical Medicine, University of Bergen, N 5020 Bergen, Norway
    Proc Natl Acad Sci U S A 107:775-80. 2010
    ..noncoding elements and overlap with the genomic regulatory blocks of the transcription factor genes HHEX, SOX4, and IRX3. We report that human highly conserved noncoding elements in LD with the risk SNPs drive expression in endoderm or ..
  20. pmc Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
    Shan Shan Zhang
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:13576-81. 2011
    ..Here we show that Iroquois homeobox gene 3 (Irx3) is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-..
  21. pmc Foxl2 functions in sex determination and histogenesis throughout mouse ovary development
    Jose Elias Garcia-Ortiz
    Laboratory of Genetics, NIA NIH IRP, Baltimore, MD, USA
    BMC Dev Biol 9:36. 2009
    ..g., Rspo1. Here we report expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit...
  22. doi Repeatability of corneal and ocular aberration measurements and changes in aberrations over one week
    Marco A Miranda
    Faculty of Life Sciences, The University of Manchester, United Kingdom
    Clin Exp Optom 92:253-66. 2009
    Both Shack-Hartmann aberrometry (IRX3, Imagine Eyes, Orsay, France) and Scheimpflug photography (Oculus Pentacam, Oculus Inc Wetzlar, Germany) are known to provide repeatable measurements...
  23. doi The Xenopus Irx genes are essential for neural patterning and define the border between prethalamus and thalamus through mutual antagonism with the anterior repressors Fezf and Arx
    Elisa Rodríguez-Seguel
    Centro Andaluz de Biologia del Desarrollo CABD, Consejo Superior de Investigaciones Cientificas Universidad Pablo de Olavide, Carretera de Utrera Km1, 41013 Sevilla, Spain
    Dev Biol 329:258-68. 2009
    ..contain six Irx genes organized in two clusters, IrxA (which harbors Irx1, Irx2 and Irx4) and IrxB (which harbors Irx3, Irx5 and Irx6)...
  24. pmc Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells
    Theresa K Kelly
    The Semel Institute for Neuroscience and Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e4213. 2009
    ..expressed between cortical and spinal cord derived neurospheres, including many Hox genes, Nuclear receptors, Irx3, Pace4, Lhx2, Emx2 and Ntrk2. NSCs in the cortex express LeX...
  25. doi Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage
    Eun Kyung Lee
    Department of Biochemistry and Molecular Biology, College of Pharmacy, and Samsung Biomedical Research Institute, Sungkyunkwan University, Suwon, Korea
    J Biol Chem 284:2891-901. 2009
    ..Reversine treatment leads to up-regulation of priming genes of neuroectodermal lineages, such as Ngn2, Nts, Irx3, Pax7, Hes1, and Hes6, through active histone modifications in the promoter regions of these genes...
  26. pmc Interaction between transcription factors Iroquois proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene transcription
    Wenjie He
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA 15219, USA
    Cardiovasc Res 81:64-71. 2009
    ..2 gene across the left ventricular wall of rodent hearts. Here, we analyse molecular mechanisms underlying the Irx5-induced regulation of the rat Kv4.2 promoter...
  27. pmc Transforming properties of 8p11-12 amplified genes in human breast cancer
    Zeng Quan Yang
    Breast Cancer Program and Systems and Computational Biology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 70:8487-97. 2010
    ..Further, we identified several WHSC1L1 target genes, one of which is iroquois homeobox 3 gene (IRX3), a member of the Iroquois homeobox transcription factor family.
  28. doi Primordial germ cell proliferation is impaired in Fused Toes mutant embryos
    Bongki Kim
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Dev Biol 349:417-26. 2011
    ..5. The six genes within the Ft locus include the IrxB cluster (Irx3, -5, -6), Fts, Ftm, and Fto, of which only Ftm, Fto, and Fts are expressed in primordial germ cells of the early ..
  29. ncbi Expression of Irx6 during mouse morphogenesis
    J Mummenhoff
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mech Dev 103:193-5. 2001
    ..Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res...
  30. doi Neuronal induction and regional identity by co-culture of adherent human embryonic stem cells with chicken notochords and somites
    Hossein Salehi
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, Esfahan, Iran
    Int J Dev Biol 55:321-6. 2011
    ..Moreover, in somite and notochord co-culture groups, hESCs-derived neuronal cells expressed HOXB4, OTX2, IRX3 and PAX6, indicative of dorsal hindbrain and ventral anterior identities, respectively...
  31. ncbi Stage-specific mice ovarian somatic cell is involved in primordial folliculogenesis
    Ge Li
    State Key Laboratory for Agro Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China
    Front Biosci (Elite Ed) 3:1025-33. 2011
    ..Here, we found after the PF pool is established, Irx3 and FoxL2 which were extensively expressed in the OSCs of the perinatal mouse decreased...
  32. pmc A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans
    Sarah C Petersen
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurosci 31:15362-75. 2011
    ..Moreover, the well established roles of these conserved transcription factors in mammalian neural development suggest that a similar cascade may also control synaptic plasticity in more complex nervous systems...
  33. pmc Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop
    Jun An Chen
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 69:721-35. 2011
    ..neurons (pMN) and V2 interneurons (p2) are specified by a pair of cross-repressive transcription factors, Olig2 and Irx3. Lineage tracing revealed that many p2 progenitors transiently express the pMN marker Olig2 during spinal cord ..
  34. doi The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice
    Bongki Kim
    Department of Animal Sciences, University of Illinois, Urbana, IL, USA
    Biol Reprod 84:1024-32. 2011
    ..Previously, we discovered that Irx3 expression was localized specifically to female gonads during embryonic development; therefore, we sought to ..
  35. doi An ancient mechanism of hindbrain patterning has been conserved in vertebrate evolution
    Eva Jimenez-Guri
    Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
    Evol Dev 13:38-46. 2011
    ..However, while Irx3 is expressed anteriorly in amniotes, a novel Irx gene, iro7, acts in teleosts...
  36. doi Cell wall composition contributes to the control of transpiration efficiency in Arabidopsis thaliana
    Yun Kuan Liang
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Plant J 64:679-86. 2010
    ..We report the identification of a new allele of the Arabidopsis CesA7 cellulose synthase locus designated AtCesA7(irx3-5) involved in the control of TE. Leaves of the AtCesA7(irx3-5) mutant are warmer than the wild type (WT)...
  37. doi Evaluation of the comparability and repeatability of four wavefront aberrometers
    Nienke Visser
    University Eye Clinic, Maastricht University Medical Centre, Maastricht, The Netherlands
    Invest Ophthalmol Vis Sci 52:1302-11. 2011
    ..To compare total ocular aberrations and corneal aberrations identified with four different aberrometers and to determine the repeatability and interobserver variability...
  38. doi Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus
    Sylvie Janssens
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    Int J Dev Biol 54:1435-42. 2010
    ..Here we show that HoxD1 and Irx3 are transcriptionally induced by the Wnt pathway during neurulation...
  39. pmc Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system
    Masanori Takahashi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    BMC Dev Biol 8:87. 2008
    ..In this study, we identified rat cad7 and cad20 and analyzed their expression patterns in embryonic and adult rat brains...
  40. doi A dual requirement for Iroquois genes during Xenopus kidney development
    Pilar Alarcon
    Centro Andaluz de Biologia del Desarrollo, CSIC UPO, Sevilla, Spain
    Development 135:3197-207. 2008
    The Iroquois (Irx) genes encode evolutionary conserved homeoproteins. We report that Xenopus genes Irx1 and Irx3 are expressed and required during different stages of Xenopus pronephros development...
  41. ncbi Irx3 is differentially up-regulated in female gonads during sex determination
    Joan S Jorgensen
    Department of Veterinary Biosciences, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Gene Expr Patterns 5:756-62. 2005
    b>Irx3 is a member of the Iroquois homeobox gene family that encodes a protein known for its essential role in spinal cord development. Transcript screening of male and female gonads during the critical period of sex determination (E12-13...
  42. pmc Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification
    E J Bellefroid
    Wellcome CRC Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    EMBO J 17:191-203. 1998
    We have identified in Xenopus and in the mouse two highly related genes, Xiro3 and Irx3 respectively, that encode a Drosophila Iroquois-related homeobox transcription factor...
  43. pmc Interactions among three distinct CesA proteins essential for cellulose synthesis
    Neil G Taylor
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 100:1450-5. 2003
    ..have an identical phenotype to previously described mutations in two other members of this gene family (IRX1 and IRX3)...
  44. ncbi Structure of cellulose-deficient secondary cell walls from the irx3 mutant of Arabidopsis thaliana
    Marie Ann Ha
    Chemistry Department, Glasgow University, Glasgow G12 8QQ, Scotland, UK
    Phytochemistry 61:7-14. 2002
    In the Arabidopsis mutant irx3, truncation of the AtCesA7 gene encoding a xylem-specific cellulose synthase results in reduced cellulose synthesis in the affected xylem cells and collapse of mature xylem vessels...
  45. ncbi Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains
    Masanori Takahashi
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Development 129:1327-38. 2002
    ..We also observed that domains of all other HD protein genes (Nkx2.2, Nkx6.1, Irx3, Dbx2 and Dbx1) were shifted and their boundaries became blurred...
  46. ncbi Gene and cluster-specific expression of the Iroquois family members during mouse development
    A C Houweling
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Mech Dev 107:169-74. 2001
    ..of the murine family were found to be organized in two cognate clusters of three genes each, Irx1, -2, -4 and Irx3, -5, -6, respectively (Peters et al., 2000)...
  47. ncbi Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system
    X Wang
    Department of Biological Sciences, National University of Singapore, 119260, Singapore, Singapore
    Mech Dev 105:191-5. 2001
    ..Interestingly, all three iroquois zebrafish genes are expressed in the notochord while only Irx3 is active in the mouse notochord. Their expression in later stages of embryogenesis was also compared.
  48. pmc Multiple cellulose synthase catalytic subunits are required for cellulose synthesis in Arabidopsis
    N G Taylor
    School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    Plant Cell 12:2529-2540. 2000
    ..IRX1 shows homology to a previously described cellulose synthase (IRX3)...
  49. ncbi The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
    M Mahlapuu
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    Development 128:155-66. 2001
    ..Expression of Foxf1 and the homeobox gene Irx3 defines the splanchnic and somatic mesodermal layers, respectively...
  50. ncbi Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart
    V M Christoffels
    Experimental and Molecular Cardiology Group, University of Amsterdam, The Netherlands
    Dev Biol 224:263-74. 2000
    ..b>Irx3 was found to be expressed specifically in the trabeculated myocardium of the ventricles...
  51. ncbi A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
    J Briscoe
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 101:435-45. 2000
    ..The combinatorial expression of three of these proteins--Nkx6.1, Nkx2.2, and Irx3--specifies the identity of three classes of neurons generated in the ventral third of the neural tube.
  52. ncbi Expression of two novel mouse Iroquois homeobox genes during neurogenesis
    D R Cohen
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Mech Dev 91:317-21. 2000
    ..Three mouse Irx genes, Irx1, Irx2 and Irx3, have been previously identified and are expressed with distinct spatio-temporal patterns during neurogenesis...
  53. ncbi Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast
    M T Lewis
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA
    Cell Tissue Res 296:549-54. 1999
    ..Data suggest IRX-2 functions in epithelial cell differentiation and demonstrate regulated expression during ductal and lobular proliferation as well as lactation...
  54. pmc Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics
    David M Brown
    Faculty of Life Science, University of Manchester, Manchester M13 9PT United Kingdom
    Plant Cell 17:2281-95. 2005
    ..similar expression pattern to the secondary cell wall-specific cellulose synthase genes IRREGULAR XYLEM1 (IRX1) and IRX3. Cross-referencing this analysis with publicly available microarray data resulted in the selection of 16 genes for ..
  55. ncbi Regional variation in mRNA transcript abundance within the ventricular wall
    Barbara Rosati
    Department of Physiology and Biophysics, Institute of Molecular Cardiology, BST Room 124, Level 6, Stony Brook University, Stony Brook, NY 11794 8661, USA
    J Mol Cell Cardiol 40:295-302. 2006
    ..The transcription factor genes Irx3, Irx5 and Etv1 were found to be expressed in transmural gradients across the ventricular wall of rat heart and also ..
  56. doi R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    Sheila M Bell
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1049-58. 2008
    ..reduced branching, a reduction in TOPGAL reporter activity, and reduced expression of the downstream Wnt target Irx3. Interbreeding the Rspo2(Tg) and Lrp6(-) alleles resulted in more severe defects consisting of marked lung ..
  57. pmc Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
    Xue Jun Li
    Department of Anatomy and the Stem Cell Research Program, Madison, Wisconsin 53705, USA
    Stem Cells 26:886-93. 2008
    ..2+, Irx3+, and Pax7-), with the exception of motor neurons (HB9+) and their progenitors (Olig2+)...
  58. ncbi Repeatability and reliability of ocular aberration measurements in contact lens wear
    Suzanne Efron
    Eurolens Research, The University of Manchester, Moffat Building, P O Box 88, Manchester M60 1QD, United Kingdom
    Cont Lens Anterior Eye 31:81-8. 2008
    ..To assess repeatability and within- and between-observer reliability when measuring ocular aberrations with and without soft contact lens wear...
  59. pmc The prepattern transcription factor Irx3 directs nephron segment identity
    Luca Reggiani
    Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, CH 8093, Zurich, Switzerland
    Genes Dev 21:2358-70. 2007
    ..To date, the genetic basis of regionalization of the nephron has remained largely unknown. Here we show that Irx3, a member of the Iroquois (Irx) gene family, acts as a master regulator of intermediate tubule fate...
  60. ncbi Identification of cellulose synthase AtCesA7 (IRX3) in vivo phosphorylation sites--a potential role in regulating protein degradation
    Neil G Taylor
    Centre for Novel Agricultural Products, Department of Biology, University of York, York, YO10 5DD, UK
    Plant Mol Biol 64:161-71. 2007
    ..This is a possible mechanism by which plants regulate the relative levels of the three proteins whose specific interaction are required to form an active cellulose synthase complex...
  61. pmc Impairment of cellulose synthases required for Arabidopsis secondary cell wall formation enhances disease resistance
    Camilo Hernández-Blanco
    Centro de Biotecnología y Genómica de Plantas, Departamento de Biotecnologia, Universidad Politecnica de Madrid, Escuela Técnica Superior Ingenieros Agrónomos, E 28040 Madrid, Spain
    Plant Cell 19:890-903. 2007
    ..In Arabidopsis thaliana, three types of CESA subunits (CESA4/IRREGULAR XYLEM5 [IRX5], CESA7/IRX3, and CESA8/IRX1) are required for secondary cell wall formation...
  62. pmc Arabidopsis MYB26/MALE STERILE35 regulates secondary thickening in the endothecium and is essential for anther dehiscence
    Caiyun Yang
    Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicstershire LE12 5RD, United Kingdom
    Plant Cell 19:534-48. 2007
    ..MYB26 regulates a number of genes linked to secondary thickening, including IRREGULAR XYLEM1 (IRX1), IRX3, IRX8, and IRX12...
  63. pmc Fluctuations in intraocular pressure and the potential effect on aberrations of the eye
    M Asejczyk-Widlicka
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    Br J Ophthalmol 91:1054-8. 2007
    ..To investigate the fluctuations in intraocular pressure during the day and to see if these are associated with changes in corneal shape and in the patterns of ocular aberrations...
  64. ncbi Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes
    Isabelle Anselme
    Biologie du Développement, CNRS UMR7622, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Dev Biol 304:208-20. 2007
    ..6-Mb deletion on chromosome 8. This deletion eliminates six genes, three members of the Iroquois gene family, Irx3, Irx5 and Irx6, which form the IrxB cluster, and three other genes of unknown function, Fts, Ftm and Fto...
  65. ncbi DNA methylation pathway alterations in an autochthonous murine model of prostate cancer
    Shannon R Morey
    Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Res 66:11659-67. 2006
    ..In contrast, hypermethylation of the 5' CpG island region of the homeobox gene Irx3 in TRAMP is associated with reduced gene expression...
  66. ncbi Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells
    Qiong Gan
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Stem Cells 25:2-9. 2007
    ..embryonic stem cells (ESCs), wherein a number of untranscribed lineage-control genes, such as Sox1, Nkx2-2, Msx1, Irx3, and Pax3, are epigenetically modified with a unique combination of activating and repressive histone modifications ..
  67. ncbi Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
    J M Ordway
    Orion Genomics, St Louis, MO 63108, USA
    Carcinogenesis 27:2409-23. 2006
    ..Finally, we report six new targets of epigenetic inactivation (IRX3, WNT10A, WNT6, RARalpha, BMP7 and ZGPAT)...
  68. ncbi Laminar organization of the early developing anterior hypothalamus
    Aurore Caqueret
    Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Dev Biol 298:95-106. 2006
    ..We examined the expression pattern of 10 of the identified genes--Cart, Cbln1, Alcam, Unc-13c, Rgs4, Lnx4, Irx3, Sax1, Ldb2 and Neurod6--by in situ hybridization in E12.5 embryos...
  69. pmc The irregular xylem3 locus of Arabidopsis encodes a cellulose synthase required for secondary cell wall synthesis
    N G Taylor
    University of Manchester, School of Biological Science, Manchester M13 9PT, United Kingdom
    Plant Cell 11:769-80. 1999
    The irregular xylem3 (irx3) mutant of Arabidopsis has a severe deficiency in secondary cell wall cellulose deposition that leads to collapsed xylem cells...

Research Grants11

  1. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..We propose three Specific Aims: 1. To define the role of Irx3 in establishing the identity of the developing distal conduction system of the mouse heart. 2...
  2. Transcriptional Control of Mammalian Sexual Development
    Sergei G Tevosian; Fiscal Year: 2010
    ..g., Sp5, Sprr2d, Irx3 and Gng13) have been recently identified as sexually dimorphic by us and others...
  3. Transcriptional Control of Mammalian Sexual Development
    SERGEI TEVOSIAN; Fiscal Year: 2009
    ..g., Sp5, Sprr2d, Irx3 and Gng13) have been recently identified as sexually dimorphic by us and others...
  4. The Role of Iroquois Homeobox Genes in Vasculogenesis
    LEONARD ANDERSON; Fiscal Year: 2007
    ..Indeed, our preliminary data indicates that Irx3 is expressed in VSMCs and is modulated in a temporal manner during VSMC differentiation from multipotent progenitor ..
  5. Sexually Dimorphic Regulation Of SF-1 In Gonadogenesis
    JOAN JORGENSEN; Fiscal Year: 2006
    ....
  6. STEROIDS REPRESS LH THROUGH PROTEIN/PROTEIN INTERACTIONS
    JOAN JORGENSEN; Fiscal Year: 2003
    ..In Aim 3, we propose to design transgenic mice in order to define the site and mechanism of steroidogenic regulation on the LHbeta subunit gene. ..