IRGM

Summary

Gene Symbol: IRGM
Description: immunity related GTPase M
Alias: IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase family M protein, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47-like protein, immunity-related GTPase family, M1, interferon-inducible protein 1
Species: human
Products:     IRGM

Top Publications

  1. Palomino Morales R, Oliver J, Gomez Garcia M, Lopez Nevot M, Rodrigo L, Nieto A, et al. Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach. Genes Immun. 2009;10:356-64 pubmed publisher
    The aim of this study was to determine the role of the ATG16L1 (rs2241880) and IRGM (rs13361189 and rs4958847) genes polymorphism in Crohn's disease (CD) and ulcerative colitis (UC)...
  2. Bekpen C, Marques Bonet T, Alkan C, Antonacci F, Leogrande M, Ventura M, et al. Death and resurrection of the human IRGM gene. PLoS Genet. 2009;5:e1000403 pubmed publisher
    ..One member of this gene family in humans, IRGM, has been recently implicated as a risk factor for Crohn's disease...
  3. Yamazaki K, Takahashi A, Takazoe M, Kubo M, Onouchi Y, Fujino A, et al. Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. Gut. 2009;58:228-32 pubmed publisher
    ..Seventeen genetic variants at eight newly identified loci, including IRGM, NKX2-3 and PTPN2, were genotyped using the TaqMan assay or the invader assay...
  4. Intemann C, Thye T, Niemann S, Browne E, Amanua Chinbuah M, Enimil A, et al. Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. PLoS Pathog. 2009;5:e1000577 pubmed publisher
    The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and of reducing the growth of intracellular pathogens in vitro...
  5. Moon C, Shin D, Kim S, Son N, Park A, Park B, et al. Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population. Inflamm Bowel Dis. 2013;19:106-14 pubmed publisher
    Recent European ancestry genome-wide association studies have identified genetic variants of IRGM as significant susceptibility loci for Crohn's disease (CD)...
  6. King K, Lew J, Ha N, Lin J, Ma X, Graviss E, et al. Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS ONE. 2011;6:e16317 pubmed publisher
    An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD)...
  7. Prescott N, Dominy K, Kubo M, Lewis C, Fisher S, Redon R, et al. Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Hum Mol Genet. 2010;19:1828-39 pubmed publisher
    ..1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD)...
  8. Dema B, Fernandez Arquero M, Maluenda C, Polanco I, Figueredo M, De la Concha E, et al. Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease. Hum Immunol. 2009;70:946-9 pubmed publisher
    ..Based on this idea, NKX2-3, ATG16L1, and IRGM which are well-established inflammatory bowel disease risk factors, could be new celiac disease (CD) candidate ..
  9. MacMicking J, Taylor G, McKinney J. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science. 2003;302:654-9 pubmed
    ..Thus, LRG-47 may serve as a critical vacuolar trafficking component used to dispose of intracellular pathogens like Mtb. ..

More Information

Publications62

  1. Massey D, Parkes M. Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy. 2007;3:649-51 pubmed
    ..Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway...
  2. Roberts R, Hollis Moffatt J, Gearry R, Kennedy M, Barclay M, Merriman T. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes Immun. 2008;9:561-5 pubmed publisher
    Genome-wide association studies have identified PHOX2B, FAM92B, IRGM and NCF4 as candidate susceptibility factors for ileal Crohn's disease (CD)...
  3. Amre D, Mack D, Morgan K, Krupoves A, Costea I, Lambrette P, et al. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm Bowel Dis. 2009;15:501-7 pubmed publisher
    Recent genome-wide studies have implicated the autophagy genes ATG16L1 and IRGM in the pathogenesis of Crohn's disease (CD). We investigated whether these genes were associated with CD in Canadian children...
  4. Durães C, Machado J, Portela F, Rodrigues S, Lago P, Cravo M, et al. Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II). Inflamm Bowel Dis. 2013;19:230-9 pubmed publisher
    ..CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD ..
  5. Glas J, Seiderer J, Bues S, Stallhofer J, Fries C, Olszak T, et al. IRGM variants and susceptibility to inflammatory bowel disease in the German population. PLoS ONE. 2013;8:e54338 pubmed publisher
    Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD ..
  6. Bekpen C, Hunn J, Rohde C, Parvanova I, Guethlein L, Dunn D, et al. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 2005;6:R92 pubmed
    ..The origin of the vertebrate p47 system is obscure. ..
  7. Meggyesi N, Kiss L, Koszarska M, Bortlik M, Duricova D, Lakatos L, et al. NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients. World J Gastroenterol. 2010;16:5233-40 pubmed
    To investigate variants of immunity-related GTPase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD)...
  8. Sorace J, Johnson R, Howard D, Drysdale B. Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family. J Leukoc Biol. 1995;58:477-84 pubmed
    ..This suggests that these genes may be members of a new family of IFN-inducible proteins. ..
  9. Wolfkamp S, te Velde A, Weersma R, Ponsioen C, Stokkers P. Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?. Eur J Gastroenterol Hepatol. 2010;22:933-7 pubmed publisher
    Autophagy-related 16-like 1 gene (ATG16L1) and immunity-related guanosine triphosphatase gene (IRGM) are associated with Crohn's disease susceptibility and autophagy. Elimination of invading pathogens is a function of autophagy...
  10. Singh S, Davis A, Taylor G, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006;313:1438-41 pubmed
    ..We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism ..
  11. Parkes M, Barrett J, Prescott N, Tremelling M, Anderson C, Fisher S, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet. 2007;39:830-2 pubmed
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2...
  12. Fisher S, Tremelling M, Anderson C, Gwilliam R, Bumpstead S, Prescott N, et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet. 2008;40:710-2 pubmed publisher
    ..to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease...
  13. Latiano A, Palmieri O, Cucchiara S, Castro M, D Inca R, Guariso G, et al. Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease. Am J Gastroenterol. 2009;104:110-6 pubmed publisher
    Recently, genome-wide association analyses have identified single nucleotide polymorphisms in the IRGM gene (rs1000113 and rs4958847) as strong candidate susceptibility factors for Crohn's disease (CD)...
  14. McCarroll S, Huett A, Kuballa P, Chilewski S, Landry A, Goyette P, et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet. 2008;40:1107-12 pubmed publisher
    ..Crohn's disease (CD) is associated with SNPs around IRGM, but coding-sequence variation has been excluded as a source of this association...
  15. Weersma R, Stokkers P, Cleynen I, Wolfkamp S, Henckaerts L, Schreiber S, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-8 pubmed publisher
    ..We confirmed the associations with IL23R (rs11209026, P=2.69E-12), ATG16L1 (rs2241880, P=4.82E-07), IRGM (rs4958847, P=2.26E-05), NKX2-3 (rs10883365, P=5.91E-06), 1q24 (rs12035082, P=1.51E-05), 5p13 (rs17234657, P=2...
  16. Singh S, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, et al. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol. 2010;12:1154-65 pubmed publisher
    b>IRGM, a human immunity-related GTPase, confers autophagic defence against intracellular pathogens by an unknown mechanism. Here, we report an unexpected mode of IRGM action...
  17. Delgado M, Singh S, de Haro S, Master S, Ponpuak M, Dinkins C, et al. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev. 2009;227:189-202 pubmed publisher
  18. Sehgal R, Berg A, Polinski J, Hegarty J, Lin Z, McKenna K, et al. Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease. Dis Colon Rectum. 2012;55:115-21 pubmed publisher
    ..7 (range, 1-5) with an average duration of disease of 14.7 years. Single-nucleotide polymorphism rs4958847 in the IRGM gene (immunity-related GTPase family, M) was the most significant single-nucleotide polymorphism in all 3 models ..
  19. Song Z, Guo C, Zhu L, Shen P, Wang H, Guo C, et al. Elevated expression of immunity-related GTPase family M in gastric cancer. Tumour Biol. 2015;36:5591-6 pubmed publisher
    ..Immunity-related GTPase family M (IRGM) is a human protein highlighted for its contribution to autophagy upon inflammation and infections...
  20. Baskaran K, Pugazhendhi S, Ramakrishna B. Association of IRGM gene mutations with inflammatory bowel disease in the Indian population. PLoS ONE. 2014;9:e106863 pubmed publisher
    Mutations in the IRGM gene have been associated with Crohn's disease in several populations but have not been explored in Indian patients with this disease...
  21. Burada F, Plantinga T, Ioana M, Rosentul D, Angelescu C, Joosten L, et al. IRGM gene polymorphisms and risk of gastric cancer. J Dig Dis. 2012;13:360-5 pubmed publisher
    The study aimed to assess the possible association of polymorphisms in the autophagy gene IRGM (rs13361189 and rs4958847) with the risk of gastric cancer...
  22. Ge J, Li L, Jin Q, Liu Y, Zhao L, Song H. Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions. Tumour Biol. 2014;35:8343-8 pubmed publisher
    Immunity-related GTPase family M protein (IRGM) is a human protein recently highlighted for its contribution to autophagy upon infections. Evidences have shown that IRGM may also play critical roles in the pathogenesis of cancer...
  23. Kimura T, Watanabe E, Sakamoto T, Takasu O, Ikeda T, Ikeda K, et al. Autophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsis. PLoS ONE. 2014;9:e91522 pubmed publisher
    ..Autophagy has been also reported to be involved in various conditions including inflammatory diseases. IRGM (human immunity-related GTPase) has an important function in eliminating Mycobacterium tuberculosis from host cells ..
  24. Song J, Kim S, Chung K, Moon C, Kim S, Kim E, et al. Association between genetic variants in the IRGM gene and tuberculosis in a Korean population. Infection. 2014;42:655-60 pubmed publisher
    To investigate immunity-related guanosine triphosphatase family M (IRGM) genetic variants associated with susceptibility to tuberculosis (TB) in a Korean population...
  25. Hansen M, Johnsen I, Stiberg K, Sherstova T, Wakita T, Richard G, et al. Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Proc Natl Acad Sci U S A. 2017;114:E3462-E3471 pubmed publisher
    ..Here we show that the human immunity-related GTPase M (IRGM), known to contribute to autophagy, plays a previously unrecognized role in this process...
  26. Xie H, Li C, Zhang M, Zhong N, Chen L. Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis. Medicine (Baltimore). 2017;96:e8189 pubmed publisher
    The human immunity-related GTPase M (IRGM) is involved in regulating autophagy against invading pathogens...
  27. Wildenberg M, Vos A, Wolfkamp S, Duijvestein M, Verhaar A, te Velde A, et al. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology. 2012;142:1493-503.e6 pubmed publisher
    Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease. It is not clear how autophagy is linked to loss of immune tolerance in the intestine...
  28. Liu Z, Zhang H, Yuan J, Ye X, Taylor G, Yang D. The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. Cell Microbiol. 2012;14:133-46 pubmed publisher
    ..Taken together, these data suggest that Irgm3 relieves the ER stress response via a PI3K/Akt dependent mechanism, which contributes to host defence against CVB3 infection. ..
  29. Brest P, Lapaquette P, Mograbi B, Darfeuille Michaud A, Hofman P. Risk predisposition for Crohn disease: a "ménage à trois" combining IRGM allele, miRNA and xenophagy. Autophagy. 2011;7:786-7 pubmed
    ..CD), an inflammatory bowel disease, is influenced by common variants at many loci like the exonic synonymous IRGM SNP (rs10065172, NM_001145805.1, c.313C>T)...
  30. Gregoire I, Richetta C, Meyniel Schicklin L, Borel S, Pradezynski F, Diaz O, et al. IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog. 2011;7:e1002422 pubmed publisher
    ..Interestingly, immunity-associated GTPase family M (IRGM), the most targeted protein, was found to interact with the autophagy-associated proteins ATG5, ATG10, MAP1CL3C and ..
  31. Pranculiene G, Steponaitiene R, Skieceviciene J, Kucinskiene R, Kiudelis G, Adamonis K, et al. Associations between NOD2, IRGM and ORMDL3 polymorphisms and pediatric-onset inflammatory bowel disease in the Lithuanian population. Medicina (Kaunas). 2016;52:325-330 pubmed publisher
    ..The aim of this study was to assess the association between NOD2, IL23R, ATG16L1, IRGM, IL10, NKX2-3 and ORMDL3 variants and early-onset IBD...
  32. Fang S, Xu Y, Zhang Y, Tian J, Li J, Li Z, et al. Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development. Atherosclerosis. 2016;251:282-290 pubmed publisher
    ..In this study, we investigated whether the immunity related GTPase (Irgm1) regulates macrophage polarization during atherosclerosis development...
  33. Bekpen C, Xavier R, Eichler E. Human IRGM gene "to be or not to be". Semin Immunopathol. 2010;32:437-44 pubmed publisher
    ..clusters on two chromosomes in the C57BL/6 mouse genome but has been reduced to only two copies in humans: IRGC and IRGM. IRGC is not involved in immunity, but the human IRGM gene plays a role in autophagy-targeted destruction of ..
  34. Yang D, Chen J, Shi C, Jing Z, Song N. Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines. Inflammation. 2014;37:593-8 pubmed publisher
    ..leprae). The objective of the study was to investigate the association between polymorphisms in IRGM, an autophagy gene, and susceptibility to leprosy, and identify possible functions of the polymorphism in the ..
  35. Yang D, Chen J, Zhang L, Cha Z, Han S, Shi W, et al. Mycobacterium leprae upregulates IRGM expression in monocytes and monocyte-derived macrophages. Inflammation. 2014;37:1028-34 pubmed publisher
    ..Immunity-related GTPase family M protein (IRGM) plays critical roles in controlling inflammation...
  36. Xia Q, Wang M, Yang X, Li X, Zhang X, Xu S, et al. Autophagy-related IRGM genes confer susceptibility to ankylosing spondylitis in a Chinese female population: a case-control study. Genes Immun. 2017;18:42-47 pubmed publisher
    ..The gist of current study is to assess the role of IBD-associated autophagy gene IRGM on AS susceptibility in a Chinese Han population...
  37. Chang C, Yang M, Lei H. Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption. PLoS ONE. 2011;6:e28323 pubmed publisher
    ..Furthermore, IFN-? induces immunity related GTPase family M member 1(IRGM1) translocation to lysosomes and prolongs its activity in Con A-treated hepatoma cells...
  38. Cleynen I, Mahachie John J, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, et al. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PLoS ONE. 2010;5:e12952 pubmed publisher
    ..The used technique can be applied to other common complex diseases as well, and will help to complete patient characterization, in order to evolve towards personalized medicine. ..
  39. Rufini S, Ciccacci C, Di Fusco D, Ruffa A, Pallone F, Novelli G, et al. Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease. Dig Liver Dis. 2015;47:744-50 pubmed publisher
    ..Recent studies identified susceptibility genes involved in autophagy. We analyzed known autophagic loci (IRGM, ULK1 and AMBRA1) previously described as associated with inflammatory bowel diseases or with other autoimmune and/..
  40. Che N, Li S, Gao T, Zhang Z, Han Y, Zhang X, et al. Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis. Clin Chim Acta. 2010;411:1645-9 pubmed publisher
    Human immunity-related GTPase M (IRGM) is found to play an important role in defense against intracellular pathogen Mycobacterium tuberculosis in vitro by regulating autophagy...
  41. Shi Y, He X, Zhu G, Tu H, Liu Z, Li W, et al. Coxsackievirus A16 elicits incomplete autophagy involving the mTOR and ERK pathways. PLoS ONE. 2015;10:e0122109 pubmed publisher
    ..Interestingly, we found that Immunity-related GTPase family M (IRGM) was crucial for the activation of CA16 infection-induced autophagy; in turn, reducing IRGM expression suppressed ..
  42. Latiano A, Palmieri O, Corritore G, Valvano M, Bossa F, Cucchiara S, et al. Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1108-17 pubmed publisher
    ..patients, by analyzing also potential gene-gene interactions with variants in NOD2/CARD15, IL23R, ATG16L1, and IRGM genes, and investigating genotype-phenotype correlation...
  43. Yuan L, Ke Z, Ma J, Guo Y, Li Y. IRGM gene polymorphisms and haplotypes associate with susceptibility of pulmonary tuberculosis in Chinese Hubei Han population. Tuberculosis (Edinb). 2016;96:58-64 pubmed publisher
    Human immunity-related GTPase M (IRGM) is found to play an important role in defense against intracellular pathogen Mycobacterium tuberculosis (M. tuberculosis) in vitro by regulating autophagy...
  44. Na S, Park S, Seo J. Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease. J Pediatr Gastroenterol Nutr. 2015;61:285-91 pubmed publisher
    ..polymorphisms of the autophagy-associated genes autophagy-related 16-like 1 (ATG16L1), immunity-related GTPase M (IRGM), Unc-51-like kinase 1 (ULK1), and NOD2 with respect to early-onset Crohn disease (CD) among Korean children...
  45. Chauhan S, Mandell M, Deretic V. IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol Cell. 2015;58:507-21 pubmed publisher
    b>IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects autophagy through an unknown mechanism. Here, we show how IRGM controls autophagy...
  46. Li Y, Feng S, Yao Y, Yang L, Xing Y, Wang Y, et al. Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies. Genet Mol Res. 2014;13:10741-53 pubmed publisher
    ..to evaluate the relationships between single-nucleotide polymorphisms (SNPs) in the immunity-related GTPase M (IRGM) gene and the risk of Crohn's disease (CD)...
  47. Lu X, Tao Y, Wu C, Zhao P, Li K, Zheng J, et al. Association between variants of the autophagy related gene--IRGM and susceptibility to Crohn's disease and ulcerative colitis: a meta-analysis. PLoS ONE. 2013;8:e80602 pubmed publisher
    Polymorphisms in immunity-related GTPase family M (IRGM) gene may be associated with inflammatory bowel disease (IBD) by affecting autophagy...
  48. Strisciuglio C, Auricchio R, Martinelli M, Staiano A, Giugliano F, Andreozzi M, et al. Autophagy genes variants and paediatric Crohn's disease phenotype: a single-centre experience. Dig Liver Dis. 2014;46:512-7 pubmed publisher
    ..Genotyping for ATG16L1, NOD2/CARD15, and IRGM1 was performed in 80 consecutive patients with Crohn's disease (median age: 11 years; range: 0.7-17.9 years)...
  49. Lu Y, Li Q, Peng J, Zhu Y, Wang F, Wang C, et al. Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population. Tuberculosis (Edinb). 2016;97:47-51 pubmed publisher
    The autophagy-related immunity-related GTPase family M protein, IRGM, plays an important role in the defense against tuberculosis (TB) infection...
  50. Bahari G, Hashemi M, Taheri M, Naderi M, Eskandari Nasab E, Atabaki M. Association of IRGM polymorphisms and susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran. ScientificWorldJournal. 2012;2012:950801 pubmed publisher
    Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. IRGM1 is an important protein in the innate immune response against intracellular pathogens by regulating autophagy...
  51. Rosentul D, Plantinga T, Farcaş M, Oosting M, Hamza O, Scott W, et al. Role of autophagy genetic variants for the risk of Candida infections. Med Mycol. 2014;52:333-41 pubmed publisher
    ..Our aim was to assess the effect of genetic variations in the ATG16L1 and IRGM autophagy genes on the susceptibility of patients with candidemia and oropharyngeal candidiasis...
  52. Craddock N, Hurles M, Cardin N, Pearson R, Plagnol V, Robson S, et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010;464:713-20 pubmed publisher
    ..Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 ..
  53. Wagner J, Sim W, Ellis J, Ong E, Catto Smith A, Cameron D, et al. Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort. PLoS ONE. 2010;5:e15376 pubmed publisher
    ..1. An additive gene-gene interaction involving TLR4, PSMG1, TNFRSF6B and IRGM was identified with CD...