Gene Symbol: IRF7
Description: interferon regulatory factor 7
Alias: IMD39, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, interferon regulatory factor 7, IRF-7, interferon regulatory factor 7G isoform, interferon regulatory factor-7H
Species: human
Products:     IRF7

Top Publications

  1. Kubota T, Matsuoka M, Chang T, Tailor P, Sasaki T, Tashiro M, et al. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem. 2008;283:25660-70 pubmed publisher
    ..acid-inducible gene I) signaling pathways, leading to phosphorylation of IRF3 (interferon regulatory factor 3) and IRF7 and stimulation of type I interferon (IFN) transcription, a process important for innate immunity...
  2. Kawai T, Sato S, Ishii K, Coban C, Hemmi H, Yamamoto M, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004;5:1061-8 pubmed
    ..Here we show that MyD88 formed a complex with the transcription factor IRF7 but not with IRF3...
  3. Wathelet M, Lin C, Parekh B, Ronco L, Howley P, Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell. 1998;1:507-18 pubmed
    ..These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo...
  4. Lu R, Au W, Yeow W, Hageman N, Pitha P. Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation. J Biol Chem. 2000;275:31805-12 pubmed
    ..Whether silencing of IRF-7 by methylation is instrumental for the process of tumorigenesis remains to be determined. ..
  5. Sirois M, Robitaille L, Allary R, Shah M, Woelk C, Estaquier J, et al. TRAF6 and IRF7 control HIV replication in macrophages. PLoS ONE. 2011;6:e28125 pubmed publisher
    ..Knocking down the expression of TRAF6 in macrophages increased HIV-1 replication and augmented the expression of IRF7 but not IRF3. Suppressing VISA had no impact on viral replication...
  6. Xu L, Wang Y, Han K, Li L, Zhai Z, Shu H. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell. 2005;19:727-40 pubmed
    ..These findings suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral IFN signaling. ..
  7. Barnes B, Richards J, Mancl M, Hanash S, Beretta L, Pitha P. Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection. J Biol Chem. 2004;279:45194-207 pubmed
  8. Wu L, Fossum E, Joo C, Inn K, Shin Y, Johannsen E, et al. Epstein-Barr virus LF2: an antagonist to type I interferon. J Virol. 2009;83:1140-6 pubmed publisher
    ..demonstrates that EBV LF2 tegument protein specifically interacts with the central inhibitory association domain of IRF7, and this interaction leads to inhibition of the dimerization of IRF7, which suppresses IFN-alpha production and ..
  9. Au W, Yeow W, Pitha P. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. Virology. 2001;280:273-82 pubmed
    ..Altogether these results suggest that the IRF-3/IRF-7 complexes are biologically active and are involved in virus-activated transcription of endogenous IFNA genes. ..

More Information


  1. Zhang L, Pagano J. Structure and function of IRF-7. J Interferon Cytokine Res. 2002;22:95-101 pubmed
    ..Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems. ..
  2. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med. 2005;201:915-23 pubmed
    ..Here we show an essential role of IL-1 receptor-associated kinase (IRAK)-1 in TLR7- and TLR9-mediated IRF7 signaling pathway. IRAK-1 directly bound and phosphorylated IRF7 in vitro...
  3. Huang Y, Walstrom A, Zhang L, Zhao Y, Cui M, Ye L, et al. Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages. PLoS ONE. 2009;4:e5397 pubmed publisher
    ..We conclude that IRF-1, IRF-7, type I IFNs, and STAT1 form a signaling feedback loop that is critical in regulating TRAIL expression in HIV-1-infected macrophages. ..
  4. Li Q, Tang L, Roberts P, Kraniak J, Fridman A, Kulaeva O, et al. Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts. Mol Cancer Res. 2008;6:770-84 pubmed publisher
    ..Bisulfite sequencing of the promoter regions of two IFN regulatory transcription factors (IRF5 and IRF7) revealed that IRF7, but not IRF5, was epigenetically silenced by methylation of CpG islands in immortal LFS cells...
  5. Ning S, Hahn A, Huye L, Pagano J. Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. J Virol. 2003;77:9359-68 pubmed
    We have shown previously that interferon regulatory factor 7 (IRF7), a multifunctional protein intimately involved in latent Epstein-Barr virus (EBV) infection, is induced as well as activated by EBV latent membrane protein 1 (LMP1), the ..
  6. Dai J, Megjugorac N, Amrute S, Fitzgerald Bocarsly P. Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells. J Immunol. 2004;173:1535-48 pubmed
  7. Jaspers I, Horvath K, Zhang W, Brighton L, Carson J, Noah T. Reduced expression of IRF7 in nasal epithelial cells from smokers after infection with influenza. Am J Respir Cell Mol Biol. 2010;43:368-75 pubmed publisher
    ..Similarly, the expression of IRF7, a key transcription factor controlling the expression of IFN-alpha, was significantly decreased in influenza-..
  8. Song Y, Izumi K, Shinners N, Gewurz B, Kieff E. IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. Proc Natl Acad Sci U S A. 2008;105:18448-53 pubmed publisher
    ..protein 1 (LMP1), a constitutively aggregated and activated pseudoreceptor, activates IFN regulatory factor 7 (IRF7) through RIP1...
  9. Au W, Moore P, LaFleur D, Tombal B, Pitha P. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. J Biol Chem. 1998;273:29210-7 pubmed
  10. Ning S, Campos A, Darnay B, Bentz G, Pagano J. TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1. Mol Cell Biol. 2008;28:6536-46 pubmed publisher
    We have recently shown that interferon regulatory factor 7 (IRF7) is activated by Epstein-Barr virus latent membrane protein 1 (LMP1), a member of the tumor necrosis factor receptor (TNFR) superfamily, through receptor-interacting protein-..
  11. Higgs R, Ní Gabhann J, Ben Larbi N, Breen E, Fitzgerald K, Jefferies C. The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol. 2008;181:1780-6 pubmed
    ..Collectively, this demonstrates a novel role for Ro52 in turning off and thus limiting IRF3-dependent type I IFN production by targeting the transcription factor for polyubiquitination and subsequent proteasomal degradation. ..
  12. Romieu Mourez R, Solis M, Nardin A, Goubau D, Baron Bodo V, Lin R, et al. Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages. Cancer Res. 2006;66:10576-85 pubmed
    ..In conclusion, transduction of active forms of IRF-3 or IRF-7 differentially modulate the apoptotic and antitumor properties of primary macrophages, with active IRF-7 leading to the acquisition of novel antitumor effector functions. ..
  13. Fitzgerald K, McWhirter S, Faia K, Rowe D, Latz E, Golenbock D, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003;4:491-6 pubmed
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. ..
  14. Ning S, Pagano J, Barber G. IRF7: activation, regulation, modification and function. Genes Immun. 2011;12:399-414 pubmed publisher
    b>Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein-Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which ..
  15. Marie I, Smith E, Prakash A, Levy D. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol. 2000;20:8803-14 pubmed
    b>Interferon regulatory factor 7 (IRF7) is an interferon (IFN)-inducible transcription factor required for activation of a subset of IFN-alpha genes that are expressed with delayed kinetics following viral infection...
  16. Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian A, Levy D, et al. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem. 2002;277:49417-21 pubmed
    b>Interferon regulatory factor 7 (IRF7) is an interferon-inducible transcription factor required for induction of delayed early interferon alpha genes and the onset of a potent antiviral state...
  17. Liang Q, Deng H, Li X, Wu X, Tang Q, Chang T, et al. Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. J Immunol. 2011;187:4754-63 pubmed publisher
    IFN regulatory factor 7 (IRF7) is a potent transcription factor of type I IFNs and IFN-stimulated genes and is known as the master regulator of type I IFN-dependent immune responses...
  18. Zhang L, Pagano J. IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol Cell Biol. 1997;17:5748-57 pubmed
    ..The identification of a functional viral ISRE and association of IRF-7 with type III latency may be relevant to the mechanism of regulation of Qp. ..
  19. Yu Y, Wang S, Hayward G. The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity. 2005;22:59-70 pubmed
    ..Here, we report that interferon regulatory factor 7 (IRF7), a key mediator of type I IFN induction, is targeted for degradation by binding to the RTA ..
  20. Genin P, Lin R, Hiscott J, Civas A. Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Mol Cell Biol. 2009;29:3435-50 pubmed publisher
    ..of other IFN-A genes disrupt IRF-3-mediated transcription, whereas a G/A substitution in the D modules enhances IRF7-mediated expression...
  21. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol. 2005;6:981-8 pubmed
    ..Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors...
  22. Oldak M, Tolzmann L, Wnorowski A, Podgórska M, Silling S, Lin R, et al. Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7. J Virol. 2011;85:178-88 pubmed publisher
    ..Our study suggests that local application of IRF-3-activating compounds might constitute an attractive novel therapeutic strategy against HPV8-associated diseases, particularly in epidermodysplasia verruciformis patients. ..
  23. Griffiths S, Koegl M, Boutell C, Zenner H, Crump C, Pica F, et al. A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication. PLoS Pathog. 2013;9:e1003514 pubmed publisher
    ..interferon family (IFN-λ) at the mRNA and protein level by directly interacting with the transcription factor IRF7. The synergistic effect of Med23 and IRF7 on IFN-λ induction suggests this is the major transcription factor for ..
  24. Laghari Z, Chen S, Li L, Huang B, Gan Z, Zhou Y, et al. Functional, signalling and transcriptional differences of three distinct type I IFNs in a perciform fish, the mandarin fish Siniperca chuatsi. Dev Comp Immunol. 2018;84:94-108 pubmed publisher
    ..Moreover, the IFNs are able to induce their own expression, and also the IRF3 and IRF7 expression, leading to the amplification of IFN cascade...
  25. Yang Y, Huang Y, Yu Y, Zhou S, Wang S, Yang M, et al. Negative regulation of the innate antiviral immune response by TRIM62 from orange spotted grouper. Fish Shellfish Immunol. 2016;57:68-78 pubmed publisher
    ..the transcription level of interferon signaling molecules, including interferon regulatory factor 3 (IRF3), IRF7, interferon-stimulated gene 15 (ISG15), melanoma differentiation-associated protein 5 (MDA5), myxovirus resistance ..
  26. Liu S, Jiang C, Duan C, Hu L, Zhang S. Expression of virus-responsive genes and their response to challenge with poly(I:C) at different stages of the annual fish Nothobranchius guentheri: Implications for an asymmetric decrease in immunity. Fish Shellfish Immunol. 2015;46:493-500 pubmed publisher
    ..including lgp2 and mda5 encoding sensor molecules, ifn-i and viperin encoding the effector molecules and irf1, irf7, stat1 and atf3 encoding the regulation elements, are either reduced remarkably or elevated markedly or show little ..
  27. Fang L, Choudhary S, Tian B, Boldogh I, Yang C, Ivanciuc T, et al. Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection. J Virol. 2015;89:2628-42 pubmed publisher
    ..kinase 1 (MSK-1) Ser 376 phosphorylation and reduced RelA Ser 276 phosphorylation, whose formation is required for IRF7 expression...
  28. Bentz G, Liu R, Hahn A, Shackelford J, Pagano J. Epstein-Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-beta. Virology. 2010;402:121-8 pubmed publisher
    ..We previously reported that Epstein-Barr virus BZLF1, an immediate-early (IE) protein, inhibits the function of IRF7, but the role of BRLF1, the other IE transactivator, in IRF regulation has not been examined...
  29. Lu L, Zhu F, Zhang M, Li Y, Drennan A, Kimpara S, et al. Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2018;115:E498-E505 pubmed publisher
    ..In addition, STAT3 negatively regulates the lethal type I IFN signaling pathway by inhibiting expression of IRF7, IRF9, STAT1, and STAT2 Inhibition of STAT3 activity by ruxolitinib synergizes with the ..
  30. Guinn Z, Brown D, Petro T. Activation of IRF3 contributes to IFN-? and ISG54 expression during the immune responses to B16F10 tumor growth. Int Immunopharmacol. 2017;50:121-129 pubmed publisher
    ..factor assays on splenic protein extracts after tumor inoculation revealed peak activation of IRF3 and IRF7 at day 6 in B6 tumor-bearing mice but not in IRF3KO tumor-bearing mice...
  31. Schoenemeyer A, Barnes B, Mancl M, Latz E, Goutagny N, Pitha P, et al. The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem. 2005;280:17005-12 pubmed
    ..IRF3 and IRF7 are activated in response to a variety of viruses or after engagement of Toll-like receptor (TLR) 3 and TLR4 by ..
  32. Yang Y, Huang Y, Yu Y, Yang M, Zhou S, Qin Q, et al. RING domain is essential for the antiviral activity of TRIM25 from orange spotted grouper. Fish Shellfish Immunol. 2016;55:304-14 pubmed publisher
    ..molecules, including interferon regulatory factor (IRF) 3, interferon-induced 35-kDa protein (IFP35), MXI, IRF7 and myeloid differentiation factor 88 (MyD88), suggesting that the positive regulation of interferon immune ..
  33. Gu L, Fullam A, McCormack N, Höhn Y, Schröder M. DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS. Biochem J. 2017;474:571-587 pubmed publisher
    ..kinase 1 and I?B-kinase-? (IKK?), the two key kinases mediating activation of IFN regulatory factor (IRF) 3 and IRF7. We previously demonstrated that DDX3 facilitates IKK? activation downstream from RIG-I and then links the ..
  34. Zarski D, Nguyen T, Le Cam A, Montfort J, Dutto G, Vidal M, et al. Transcriptomic Profiling of Egg Quality in Sea Bass (Dicentrarchus labrax) Sheds Light on Genes Involved in Ubiquitination and Translation. Mar Biotechnol (NY). 2017;19:102-115 pubmed publisher
    ..importance of some of the genes already reported to be potential molecular quality indicators (mainly rnf213 and irf7), but we also found new genes (mainly usp5, mem-prot, plec, cenpf), which had not yet been reported to be quality-..
  35. Nikbakht Dastjerdi M, Momeni M, Bidaki R, Khaleghinia M, Karimi Googheri M, Kazemi Arababadi M, et al. The effect of depression and anxiety on expression levels of toll like receptor signaling molecules in chronic HBV infected patients. Med J Islam Repub Iran. 2015;29:180 pubmed
    ..Our previous study revealed that mRNA levels of IRAKIRAK4, TRAF3 and IRF7 were significantly decreased in chronic HBV infected (CHB) patients when compared to healthy controls...
  36. Liao Y, Jiang J, Liang B, Wei F, Huang J, Pan P, et al. Opiate use inhibits TLR9 signaling pathway in vivo: possible role in pathogenesis of HIV-1 infection. Sci Rep. 2017;7:13071 pubmed publisher
    ..Opiate use alone led to lower expression of TLR9, IRF7, and IFN-? at the protein level in PBMCs...
  37. Chen P, Guan Y, Zha G, Jiao X, Zhu H, Zhang C, et al. Swine IRF3/IRF7 attenuates inflammatory responses through TLR4 signaling pathway. Oncotarget. 2017;8:61958-61968 pubmed publisher
    To explore the role of IRF3/IRF7 during inflammatory responses, we investigated the effects of swine IRF3/IRF7 on TLR4 signaling pathway and inflammatory factors expression in porcine kidney epithelial PK15 cell lines...
  38. Eslamloo K, Xue X, Booman M, Smith N, Rise M. Transcriptome profiling of the antiviral immune response in Atlantic cod macrophages. Dev Comp Immunol. 2016;63:187-205 pubmed publisher
    ..g. stat1 and nfkbia) and transcription activators (e.g. irf7 and irf10) in the MyD88-independent and dependent signalling pathways. Several immune effectors (e.g...
  39. Bin L, Li X, Richers B, Streib J, Hu J, Taylor P, et al. Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. J Allergy Clin Immunol. 2018;141:2085-2093.e1 pubmed publisher
    ..methods, we demonstrated that ANKRD1 formed protein complexes with interferon regulatory factor (IRF) 3 and IRF7, which are important transcription factors regulating signaling transduction of pattern recognition receptors...
  40. Buss C, Opitz B, Hocke A, Lippmann J, van Laak V, Hippenstiel S, et al. Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells. J Immunol. 2010;184:3072-8 pubmed publisher
    ..Moreover, C. pneumoniae infection led to IRF3 and IRF7 nuclear translocation in HUVECs and RNA interference experiments showed that IRF3 and IRF7 as well as the ..
  41. Smith E, Marie I, Prakash A, Garcia Sastre A, Levy D. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem. 2001;276:8951-7 pubmed virus-infected cells requires phosphorylation-induced activation of the transcription factors IRF3 and IRF7. However, the kinase(s) that targets these proteins has not been identified...
  42. Ibrahim M, Khedr A, Bader El Din N, Khairy A, El Awady M. Increased incidence of cytomegalovirus coinfection in HCV-infected patients with late liver fibrosis is associated with dysregulation of JAK-STAT pathway. Sci Rep. 2017;7:10364 pubmed publisher
    ..238-3.181, p = 0.005). qRT-PCR showed downregulation of STAT2 (p = 0.006) and IRF7 (p = 0.02) in CMV positive group compared to CMV negative one...
  43. Chen X, Hu Y, Shan L, Yu X, Hao K, Wang G. Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells. Fish Shellfish Immunol. 2017;63:245-254 pubmed publisher
    ..Interestingly, though honokiol motivated the expression of IFN-? promoter stimulator 1 (IPS-1), IRF3 and IRF7, it failed to up-regulate the expression of IFN-I, indicating that honokiol enhanced the host innate antiviral ..
  44. Lazear H, Govero J, Smith A, Platt D, Fernandez E, Miner J, et al. A Mouse Model of Zika Virus Pathogenesis. Cell Host Microbe. 2016;19:720-30 pubmed publisher
    ..Four- to six-week-old Irf3(-/-)Irf5(-/-)Irf7(-/-) triple knockout mice, which produce little interferon ?/?, and mice lacking the interferon receptor (Ifnar1(-/-..
  45. Xu F, Kang Y, Zhuang N, Lu Z, Zhang H, Xu D, et al. Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program. Sci Rep. 2016;6:18778 pubmed publisher
    ..The failure to remove the Bcl6 regulator, however, impedes the antiviral signaling and exaggerates viral pneumonia in mice. We thus reveal a novel key molecular checkpoint to orchestrate antiviral innate immunity. ..
  46. Faridi M, Khan S, Zhao W, Lee H, Altintas M, Zhang K, et al. CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus. J Clin Invest. 2017;127:1271-1283 pubmed publisher
    ..TLR-stimulated macrophages from CD11B SNP carriers showed increased basal expression of IFN regulatory factor 7 (IRF7) and IFN-β, as well as increased nuclear exclusion of FOXO3, which was suppressed by LA1-dependent activation of ..
  47. Narulla M, Alsairi A, Charmier L, Noonan S, Conroy D, Hall W, et al. Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ. J Virol. 2017;91: pubmed publisher
    ..Here we report that HBZ significantly enhances interferon regulatory factor 7 (IRF7)-induced IFN-α- and IFN-stimulated response element (ISRE) promoter activities and IFN-α ..
  48. Joo C, Shin Y, Gack M, Wu L, Levy D, Jung J. Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3. J Virol. 2007;81:8282-92 pubmed
    ..Here, we report a novel immune evasion mechanism of KSHV vIRF3 to block cellular IRF7-mediated innate immunity in response to viral infection...
  49. Xu D, Zhang Y, Zhao L, Cao M, Lingel A, Zhang L. Interferon regulatory factor 7 is involved in the growth of Epstein-Barr virus-transformed human B lymphocytes. Virus Res. 2015;195:112-8 pubmed publisher
    The cellular interferon (IFN) regulatory factor-7 (IRF7) is closely associated with the Epstein-Barr virus (EBV)-mediated transformation of B lymphocytes in vitro and in vivo...
  50. Tong C, Tian F, Tang Y, Feng C, Guan L, Zhang C, et al. Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau. Fish Shellfish Immunol. 2016;50:34-42 pubmed publisher
    ..Within this gene family, IRF3, IRF5, IRF7 and IRF8 contained positive selection sites...
  51. Guiducci C, Ghirelli C, Marloie Provost M, Matray T, Coffman R, Liu Y, et al. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med. 2008;205:315-22 pubmed publisher
    ..Thus, PI3K selectively controls type I IFN production by regulating IRF-7 nuclear translocation in human pDCs and could serve as a novel target to inhibit pathogenic type I IFN in autoimmune diseases. ..
  52. Huang Y, Yang M, Yu Y, Yang Y, Zhou L, Huang X, et al. Grouper TRIM13 exerts negative regulation of antiviral immune response against nodavirus. Fish Shellfish Immunol. 2016;55:106-15 pubmed publisher
    ..not only negatively regulated the interferon promoter activity induced by interferon regulator factor (IRF) 3, IRF7, and melanoma differentiation-associated protein 5 (MDA5), but also decreased the expression of several interferon ..
  53. Wang Z, Zheng Y, Hou C, Yang L, Li X, Lin J, et al. DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF-7 binding activity in fulminant type 1 diabetes. J Autoimmun. 2013;41:50-9 pubmed publisher
  54. Yu F, Wang L, Wang H, Sheng J, Lu L. Repression of SUMOylation pathway by grass carp reovirus contributes to the upregulation of PKR in an IFN-independent manner. Oncotarget. 2017;8:71500-71511 pubmed publisher
    ..that IRF2 and PKR were significantly up-regulated in CIK cells treated with inhibitor in contrast to IRF1, IRF7 and IFNI...
  55. Licastro F, Raschi E, Carbone I, Porcellini E. Variants in Antiviral Genes are Risk Factors for Cognitive Decline and Dementia. J Alzheimers Dis. 2015;46:655-63 pubmed publisher
    ..EBV and HHV-6 plasma IgG levels were also investigated and EBV IgG levels were increased in AD with the IRF7 GG genotype...
  56. Pfaller C, Conzelmann K. Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. J Virol. 2008;82:12365-73 pubmed publisher
    ..kinase 1 (IRAK1), IRAK4, and IkappaB kinase alpha (IKKalpha), which activates IFN regulatory factor 7 (IRF7) and is independent of the canonical kinases TBK1 and IKKepsilon...
  57. Lin L, Ling P, Liu M. The potential role of interferon-regulatory factor 7 among Taiwanese patients with systemic lupus erythematosus. J Rheumatol. 2011;38:1914-9 pubmed publisher
    ..Our aims were to investigate the expression of IRF7 and its correlation with disease activity and to explore the association in Taiwanese patients between 2 genetic ..
  58. Kondo T, Watanabe M, Hatakeyama S. TRIM59 interacts with ECSIT and negatively regulates NF-?B and IRF-3/7-mediated signal pathways. Biochem Biophys Res Commun. 2012;422:501-7 pubmed publisher
    ..Furthermore, TRIM59 inhibited phosphorylation and dimerization of IRF3 and IRF7, suggesting that TRIM59 negatively regulates upstream kinases for IRFs...
  59. Bin L, Edwards M, Heiser R, Streib J, Richers B, Hall C, et al. Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol. 2014;134:848-55 pubmed publisher
    ..that the upstream regulators of type I and type III interferons, interferon regulatory factor (IRF) 3 and IRF7, were significantly inhibited in patients with ADEH+ based on the downregulation of their target genes...
  60. Liu J, Huang X, Yu Y, Zhang J, Ni S, Hu Y, et al. Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection. Fish Shellfish Immunol. 2017;71:95-104 pubmed publisher
    ..the interferon promoter activity, and the activation of interferon immune response was regulated by both IRF3 and IRF7. Together, our results firstly showed that fish DDX3X exerted crucial roles in antiviral immunity against RNA virus ..
  61. Zheng L, Yu C, Zhang Z, Yang C, Cai X. Expression of interferon regulatory factor 1, 3, and 7 in primary Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:661-8 pubmed publisher
    ..Peripheral blood cells and parotid gland biopsy specimens from patients with pSS were studied. The IRF1, IRF3, and IRF7 gene mRNA levels in peripheral blood cells were calculated by using real-time PCR...
  62. Sun Y, Yang Q, Zhao X, Liu X, Xu T. Identification and functional characterization of interferon regulatory factor 7 involved in activation JAK/STAT pathway in miiuy croaker. Fish Shellfish Immunol. 2018;73:50-56 pubmed publisher
    ..b>IRF7 is important to regulate the response of type I interferon (IFN) to viral infection...
  63. Schmid S, Sachs D, tenOever B. Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virus. J Biol Chem. 2014;289:299-311 pubmed publisher
    ..We find that activation of IRF7 results in the induction of MAP3K8 and restructuring of the antiviral transcriptome...
  64. Qian W, Wei X, Li Y, Guo K, Zou Z, Zhou H, et al. Duck interferon regulatory factor 1 acts as a positive regulator in duck innate antiviral response. Dev Comp Immunol. 2018;78:1-13 pubmed publisher
    ..interacts with duck myeloid differentiation factor 88 (duMyD88) to activate duck IFN-?, different from IRF3 and IRF7, which involve in IFN expression through the retinoic acid-inducible gene I (RIG-I)-like receptor pathway in ..
  65. Laghari Z, Li L, Chen S, Huo H, Huang B, Zhou Y, et al. Composition and transcription of all interferon regulatory factors (IRFs), IRF1‒11 in a perciform fish, the mandarin fish, Siniperca chuatsi. Dev Comp Immunol. 2018;81:127-140 pubmed publisher
    ..species of fish, the mandarin fish, Siniperca chuatsi, in addition to the previous report of IRF1, IRF2, IRF3 and IRF7 from the fish...
  66. Egarnes B, Blanchet M, Gosselin J. Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice. PLoS ONE. 2017;12:e0186639 pubmed publisher
    ..While treatment of mice with Csn-B induces phosphorylation of transcriptional factors IRF3 and IRF7, the latter appears to be less indispensable since effects of Csn-B treatment on the synthesis of IFNs were ..
  67. Ohguchi A, Yamauchi H, Doi K, Nakayama H. Activation of type I interferon signaling in the parotid and exorbital lachrymal glands during the acute phase of encephalomyocarditis (EMC) virus infection in mice. Exp Mol Pathol. 2016;100:434-40 pubmed publisher
    ..The up-regulation of IFN-stimulated genes (ISGs), such as Irf7, Pkr and Oas, was quickly induced at 2DPI in the parotid gland, and this probably contributed to suppress viral ..
  68. Siednienko J, Maratha A, Yang S, Mitkiewicz M, Miggin S, Moynagh P. Nuclear factor ?B subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated ?-interferon production via induction of transcriptional repressor protein YY1. J Biol Chem. 2011;286:44750-63 pubmed publisher
    ..and nuclear translocation of YinYang1 where it interacts with the IFN-? promoter and inhibits the binding of IRF7 to the latter...
  69. Nasr N, Alshehri A, Wright T, Shahid M, Heiner B, Harman A, et al. Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages. J Virol. 2017;91: pubmed publisher
    ..We further define the induction pathway, showing sequential HIV RNA stimulation via Tat, RIGI, MAVS, IRF1, and IRF7, also identified by siRNA knockdown. IRF1 also plays a key role in the first phase...
  70. Bosco A, Ehteshami S, Panyala S, Martinez F. Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo. J Allergy Clin Immunol. 2012;129:88-94 pubmed publisher
    ..of the wiring diagram of the modules revealed the presence of hyperconnected hub nodes, most notably interferon regulatory factor 7, which was identified as a major hub linking interferon-mediated antiviral responses...
  71. Sarker S, Wang Y, Warren Smith B, Helbig K. Dynamic Changes in Host Gene Expression following In Vitro Viral Mimic Stimulation in Crocodile Cells. Front Immunol. 2017;8:1634 pubmed publisher
    ..of many genes known to be involved in the mammalian response to viral infection, including viperin, Mx1, IRF7, IRF1, and RIG-I with approximately 10% of the genes being uncharacterized transcripts...
  72. Hu Y, Huang Y, Liu J, Zhang J, Qin Q, Huang X. TBK1 from orange-spotted grouper exerts antiviral activity against fish viruses and regulates interferon response. Fish Shellfish Immunol. 2018;73:92-99 pubmed publisher
    ..In addition, the overexpression of EcTBK1 increased the IRF3- and IRF7-regulated interferon promoter ISRE and IFN activity, and the regulatory effect on interferon immune response were ..
  73. Zhang J, Hu M, Shu H, Li S. Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol. 2014;11:245-52 pubmed publisher
    ..Here, we identified death-associated protein kinase 1 (DAPK1) as an IRF7-interacting protein by tandem affinity purification (TAP)...
  74. Rieder M, Brzózka K, Pfaller C, Cox J, Stitz L, Conzelmann K. Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity. J Virol. 2011;85:842-52 pubmed publisher
    ..aa) 176 to 181, 182 to 186, or 176 to 186 were severely compromised in counteracting phosphorylation of IRF3 and IRF7 by TBK1 or IKKi while retaining the full capacity of preventing nuclear import of activated STATs and of supporting ..
  75. Lu R, Moore P, Pitha P. Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility. J Biol Chem. 2002;277:16592-8 pubmed
    b>Interferon regulatory factor 7 (IRF-7) plays an important role in innate immunity, where, together with IRF-3, it controls the expression of interferon A/B genes as well as chemokine RANTES (regulated on activation normal T cell expressed ..
  76. Agod Z, Fekete T, Budai M, Varga A, Szabo A, Moon H, et al. Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells. Redox Biol. 2017;13:633-645 pubmed publisher
    ..mediators slightly, whereas reduced type I IFN production markedly via blocking phosphorylation of interferon regulatory factor 7 (IRF7), the key transcription factor of the TLR9 signaling pathway...
  77. Zhan F, Liu H, Lai R, Jakovlić I, Wang W. Expression and functional characterization of interferon regulatory factors (irf2, irf7 and irf9) in the blunt snout bream (Megalobrama amblycephala). Dev Comp Immunol. 2017;67:239-248 pubmed publisher
    ..In this study, three irf family members (irf2, irf7, irf9) were identified and characterized in Megalobrama amblycephala at the mRNA and amino acid levels. M...
  78. Qing J, Liu C, Choy L, Wu R, Pagano J, Derynck R. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol. 2004;24:1411-25 pubmed
    ..Our studies underscore a role of TGF-beta/Smad3 signaling in IRF-7-mediated induction of IFN-beta expression. ..
  79. Liang Q, Fu B, Wu F, Li X, Yuan Y, ZHU F. ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKK? and TBK1 as an alternative substrate. J Virol. 2012;86:10162-72 pubmed publisher
    ..Natl. Acad. Sci. U. S. A., 99:5573-5578, 2002) that ORF45 suppresses activation of interferon regulatory factor 7 (IRF7), a crucial regulator of type I interferon gene expression, by blocking its virus-induced ..
  80. Hu Y, Wang J, Yang B, Zheng N, Qin M, Ji Y, et al. Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. J Immunol. 2011;187:6456-62 pubmed publisher
    b>IRF7 is known as the master regulator in virus-triggered induction of type I IFNs (IFN-I). In this study, we identify GBP4 virus-induced protein interacting with IRF7 as a negative regulator for IFN-I response...
  81. Gates Tanzer L, Shisler J. Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression. J Biol Chem. 2018;293:1745-1755 pubmed publisher
    ..Here we examined the signal transduction events that occur during TLR9-induced IRF7 activation...
  82. Chen J, Zhou J, Bae W, Sanders C, Nolan J, Cai H. A yEGFP-based reporter system for high-throughput yeast two-hybrid assay by flow cytometry. Cytometry A. 2008;73:312-20 pubmed publisher
  83. Zhong B, Zhang L, Lei C, Li Y, Mao A, Yang Y, et al. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 2009;30:397-407 pubmed publisher
    ..These findings suggest that RNF5 negatively regulates virus-triggered signaling by targeting MITA for ubiquitination and degradation at the mitochondria. ..