IRF6

Summary

Gene Symbol: IRF6
Description: interferon regulatory factor 6
Alias: LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1, interferon regulatory factor 6
Species: human
Products:     IRF6

Top Publications

  1. Huang Y, Wu J, Ma J, Beaty T, Sull J, Zhu L, et al. Association between IRF6 SNPs and oral clefts in West China. J Dent Res. 2009;88:715-8 pubmed publisher
    Analyses of previous data have confirmed the contribution of the IRF6 gene to susceptibility to non- syndromic oral clefts (NSOC) in some populations...
  2. Schutte B, Bjork B, Coppage K, Malik M, Gregory S, Scott D, et al. A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. Genome Res. 2000;10:81-94 pubmed
    Van der Woude syndrome (VWS) is a common form of syndromic cleft lip and palate and accounts for approximately 2% of all cleft lip and palate cases...
  3. Little H, Rorick N, Su L, Baldock C, Malhotra S, Jowitt T, et al. Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6. Hum Mol Genet. 2009;18:535-45 pubmed publisher
    ..CLP, lip pits, skin-folds, syndactyly and oral adhesions which arise as the result of mutations in interferon regulatory factor 6 (IRF6)...
  4. Malik S, Kakar N, Hasnain S, Ahmad J, Wilcox E, Naz S. Epidemiology of Van der Woude syndrome from mutational analyses in affected patients from Pakistan. Clin Genet. 2010;78:247-56 pubmed publisher
    Mutations in IRF6 cause Van der Woude syndrome (VWS), one of the most common syndromes associated with cleft lip (CL) with or without cleft palate (CP)...
  5. Beaty T, Murray J, Marazita M, Munger R, Ruczinski I, Hetmanski J, et al. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet. 2010;42:525-9 pubmed publisher
    ..432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance...
  6. Bocian M, Walker A. Lip pits and deletion 1q32----41. Am J Med Genet. 1987;26:437-43 pubmed
    ..To our knowledge, interstitial deletion of the segment 1q32----41 has not been reported. This observation raises the possibility that the van der Woude syndrome may be due to a submicroscopic deletion of chromosome 1q. ..
  7. Carter T, Molloy A, Pangilinan F, Troendle J, Kirke P, Conley M, et al. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. Birth Defects Res A Clin Mol Teratol. 2010;88:84-93 pubmed publisher
    ..whether reported associations between nonsyndromic oral clefts and 12 genes (CLPTM1, CRISPLD2, FGFR2, GABRB3, GLI2, IRF6, PTCH1, RARA, RYK, SATB2, SUMO1, TGFA) could be confirmed...
  8. de Lima R, Hoper S, Ghassibe M, Cooper M, Rorick N, Kondo S, et al. Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome. Genet Med. 2009;11:241-7 pubmed publisher
    b>Interferon regulatory factor 6 encodes a member of the IRF family of transcription factors. Mutations in interferon regulatory factor 6 cause Van der Woude and popliteal pterygium syndrome, two related orofacial clefting disorders...
  9. Bailey C, Abbott D, Margaryan N, Khalkhali Ellis Z, Hendrix M. Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. Mol Cell Biol. 2008;28:2235-43 pubmed publisher
    b>Interferon regulatory factor 6 (IRF6) is a novel and unique member of the IRF family of transcription factors...

More Information

Publications72

  1. Letra A, Fakhouri W, Fonseca R, Menezes R, Kempa I, Prasad J, et al. Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate. PLoS ONE. 2012;7:e45441 pubmed publisher
    Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact...
  2. Ghassibe M, Revencu N, Bayet B, Gillerot Y, Vanwijck R, Verellen Dumoulin C, et al. Six families with van der Woude and/or popliteal pterygium syndrome: all with a mutation in the IRF6 gene. J Med Genet. 2004;41:e15 pubmed
  3. Item C, Turhani D, Thurnher D, Yerit K, Sinko K, Wittwer G, et al. Van Der Woude syndrome: variable penetrance of a novel mutation (p.Arg 84Gly) of the IRF6 gene in a Turkish family. Int J Mol Med. 2005;15:247-51 pubmed
    ..Mutations of the interferon regulatory factor 6 gene (IRF6) have been recently described in patients with VWS...
  4. Ghassibe M, Bayet B, Revencu N, Verellen Dumoulin C, Gillerot Y, Vanwijck R, et al. Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population. Eur J Hum Genet. 2005;13:1239-42 pubmed
    ..The interferon regulatory factor-6 (IRF6) gene has been shown to harbor mutations in patients with van der Woude syndrome, a dominant form of clefts ..
  5. Richardson R, Dixon J, Malhotra S, Hardman M, Knowles L, Boot Handford R, et al. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet. 2006;38:1329-34 pubmed
    ..Here, we show that mice carrying a homozygous missense mutation in interferon regulatory factor 6 (Irf6), the homolog of the gene mutated in the human congenital disorders Van der Woude syndrome and ..
  6. Rojas Martinez A, Reutter H, Chacon Camacho O, Leon Cachon R, Munoz Jimenez S, Nowak S, et al. Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Mesoamerican population: Evidence for IRF6 and variants at 8q24 and 10q25. Birth Defects Res A Clin Mol Teratol. 2010;88:535-7 pubmed publisher
    ..NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The IRF6 gene and three further susceptibility loci at 8q24, 10q25, and 17q22, which were identified by a recent genome-wide ..
  7. Brosch S, Baur M, Blin N, Reinert S, Pfister M. A novel IRF6 nonsense mutation (Y67X) in a German family with Van der Woude syndrome. Int J Mol Med. 2007;20:85-9 pubmed
    ..VWS arises as the result of mutations in the gene encoding interferon regulatory factor 6 (IRF6)...
  8. Salahshourifar I, Wan Sulaiman W, Halim A, Zilfalil B. Mutation screening of IRF6 among families with non-syndromic oral clefts and identification of two novel variants: review of the literature. Eur J Med Genet. 2012;55:389-93 pubmed publisher
    ..Thus, about 15% of VWS cases are indistinguishable from cases with non-syndromic oral clefts. IRF6 mutations are the major cause of VWS; however, variants in this gene show strong association with non-syndromic ..
  9. Vieira A, Seymen F, Patir A, Menezes R. Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population. Arch Oral Biol. 2008;53:780-4 pubmed publisher
    Recently, the IRF6 contribution that was reported for Van der Woude syndrome and non-syndromic oral clefts was extended to isolated tooth agenesis...
  10. Mostowska A, Hozyasz K, Wojcicki P, Biedziak B, Paradowska P, Jagodzinski P. Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population. Birth Defects Res A Clin Mol Teratol. 2010;88:538-45 pubmed publisher
    ..We performed an analysis of 18 polymorphisms of FOXE1, IRF6, MSX1, PAX9, TBX10, FGF10, FGFR1, TGFalpha, TGFbeta3, SUMO1, and the chromosomal region 8q24 in a group of 175 ..
  11. Mangold E, Ludwig K, Birnbaum S, Baluardo C, Ferrian M, Herms S, et al. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. Nat Genet. 2010;42:24-6 pubmed publisher
    ..07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56). ..
  12. Scioletti A, Brancati F, Gatta V, Antonucci I, Peissel B, Pizzuti A, et al. Two novel mutations affecting splicing in the IRF6 gene associated with van der Woude syndrome. J Craniofac Surg. 2010;21:1654-6 pubmed publisher
    ..Different studies have demonstrated an association between VWS and mutations of the IRF6 (interferon regulatory factor) gene...
  13. Vieira A, Cooper M, Marazita M, Orioli I, Castilla E. Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South America. Am J Med Genet A. 2007;143A:2075-8 pubmed
  14. Park J, McIntosh I, Hetmanski J, Jabs E, Vander Kolk C, Wu Chou Y, et al. Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations. Genet Med. 2007;9:219-27 pubmed
    The interferon regulatory factor 6 (IRF6), the gene that causes van der Woude syndrome has been shown to be associated with nonsyndromic cleft lip with or without palate in several populations...
  15. Rahimov F, Marazita M, Visel A, Cooper M, Hitchler M, Rubini M, et al. Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet. 2008;40:1341-7 pubmed publisher
    ..nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs in IRF6 (interferon regulatory factor 6)...
  16. Birnbaum S, Ludwig K, Reutter H, Herms S, Steffens M, Rubini M, et al. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet. 2009;41:473-7 pubmed publisher
    ..05 (95% CI = 3.88-9.43) for the homozygous genotype. The calculated population attributable risk for this marker is 0.41, suggesting that this study has identified a major susceptibility locus for NSCL/P. ..
  17. Yeetong P, Mahatumarat C, Siriwan P, Rojvachiranonda N, Suphapeetiporn K, Shotelersuk V. Three novel mutations of the IRF6 gene with one associated with an unusual feature in Van der Woude syndrome. Am J Med Genet A. 2009;149A:2489-92 pubmed publisher
    ..It remains the most common syndromic form of oral clefts. Mutations in the interferon regulatory factor 6 (IRF6) gene have been identified in patients with VWS...
  18. Rutledge K, Barger C, Grant J, Robin N. IRF6 mutations in mixed isolated familial clefting. Am J Med Genet A. 2010;152A:3107-9 pubmed publisher
    Mutations in the interferon regulatory factor 6 (IRF6) gene are known to cause van der Woude syndrome (VWS), a common syndromic form of oro-facial clefting characterized by the familial occurrence of mixed clefting (cleft lip with or ..
  19. Lees M, Winter R, Malcolm S, Saal H, Chitty L. Popliteal pterygium syndrome: a clinical study of three families and report of linkage to the Van der Woude syndrome locus on 1q32. J Med Genet. 1999;36:888-92 pubmed
    Popliteal pterygium syndrome (PPS) is a rare autosomal dominant disorder, thought to occur with an incidence of approximately 1 in 300 000 live births...
  20. Jia Z, Li Y, Li L, Wu J, Zhu L, Yang C, et al. Association among IRF6 polymorphism, environmental factors, and nonsyndromic orofacial clefts in western china. DNA Cell Biol. 2009;28:249-57 pubmed publisher
    The interferon regulatory factor 6 (IRF6) gene and environmental factors have been shown to be associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in several populations...
  21. Jugessur A, Rahimov F, Lie R, Wilcox A, Gjessing H, Nilsen R, et al. Genetic variants in IRF6 and the risk of facial clefts: single-marker and haplotype-based analyses in a population-based case-control study of facial clefts in Norway. Genet Epidemiol. 2008;32:413-24 pubmed publisher
    Mutations in the gene encoding interferon regulatory factor 6 (IRF6) underlie a common form of syndromic clefting known as Van der Woude syndrome...
  22. Larrabee Y, Birkeland A, Kent D, Flores C, Su G, Lee J, et al. Association of common variants, not rare mutations, in IRF6 with nonsyndromic clefts in a Honduran population. Laryngoscope. 2011;121:1756-9 pubmed publisher
    ..Linkage studies have shown interferon regulatory factor 6 (IRF6) to be associated with CL/P in multiple populations, including one in Honduras...
  23. Kondo S, Schutte B, Richardson R, Bjork B, Knight A, Watanabe Y, et al. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet. 2002;32:285-9 pubmed
    b>Interferon regulatory factor 6 (IRF6) belongs to a family of nine transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein-binding domain...
  24. Vieira A, Modesto A, Meira R, Barbosa A, Lidral A, Murray J. Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis. Am J Med Genet A. 2007;143A:538-45 pubmed
    ..We investigated two genes responsible for craniofacial syndromes, FGFR1 and IRF6, in a collection of families with isolated tooth agenesis...
  25. Srichomthong C, Siriwan P, Shotelersuk V. Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai population. J Med Genet. 2005;42:e46 pubmed
    Previous data have shown an association between DNA sequence variants in the IRF6 gene and an increased risk of non-syndromic cleft lip with or without cleft palate (CL/P) in some populations...
  26. Jagomagi T, Nikopensius T, Krjutskov K, Tammekivi V, Viltrop T, Saag M, et al. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. Eur J Oral Sci. 2010;118:213-20 pubmed publisher
    ..Epistatic interactions were observed for SNPs within PVRL2, between BCL3 and EDN1, and between IRF6 and MSX1 genes...
  27. Li M, Zhu W, Wang Y, Guo J, Li S, Li Y. [Association between polymorphism of IRF6 rs2235371 locus and nonsyndromic cleft lip with or without cleft palate]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29:149-54 pubmed publisher
    To assess the association between polymorphism of interferon regulatory factor 6 (IRF6) gene rs2235371 locus and nonsyndromic cleft lip with or without cleft palate in Chinese population.
  28. Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, et al. A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest. 2010;120:1570-7 pubmed publisher
    ..Mutations in the p63 and interferon regulatory factor 6 (IRF6) genes have been found in human patients with these syndromes, consistent with phenotypes...
  29. Zucchero T, Cooper M, Maher B, Daack Hirsch S, Nepomuceno B, Ribeiro L, et al. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med. 2004;351:769-80 pubmed
    ..We identified the gene that encodes interferon regulatory factor 6 (IRF6) as a candidate gene on the basis of its involvement in an autosomal dominant form of cleft lip ..
  30. Pan Y, Ma J, Zhang W, Du Y, Niu Y, Wang M, et al. IRF6 polymorphisms are associated with nonsyndromic orofacial clefts in a Chinese Han population. Am J Med Genet A. 2010;152A:2505-11 pubmed publisher
    b>IRF6 plays an important role in orofacial development...
  31. Brito L, Bassi C, Masotti C, Malcher C, Rocha K, Schlesinger D, et al. IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population. Am J Med Genet A. 2012;158A:2170-5 pubmed publisher
    ..Among the putative susceptibility loci, the IRF6 gene and a region at 8q24.21 have been corroborated in different populations...
  32. Song T, Wu D, Wang Y, Li H, Yin N, Zhao Z. SNPs and interaction analyses of IRF6, MSX1 and PAX9 genes in patients with non?syndromic cleft lip with or without palate. Mol Med Rep. 2013;8:1228-34 pubmed publisher
    ..The genes interferon regulatory factor 6 (IRF6), muscle segment homeobox 1 (MSX1) and paired box gene 9 (PAX9) are important for the ..
  33. Tan E, Lim E, Yap S, Lee S, Cheng J, Por Y, et al. Identification of IRF6 gene variants in three families with Van der Woude syndrome. Int J Mol Med. 2008;21:747-51 pubmed
    ..Several mutations in the interferon regulatory factor 6 (IRF6) gene have been found in VWS families, suggesting that this gene is the primary locus...
  34. Birnbaum S, Ludwig K, Reutter H, Herms S, de Assis N, Diaz Lacava A, et al. IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate. Eur J Oral Sci. 2009;117:766-9 pubmed publisher
    Variants in the interferon regulatory factor 6 (IRF6) gene have repeatedly been associated with non-syndromic cleft lip with or without cleft palate (NSCL/P)...
  35. Wu T, Liang K, Hetmanski J, Ruczinski I, Fallin M, Ingersoll R, et al. Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate. Hum Genet. 2010;128:401-10 pubmed publisher
    ..non-syndromic cleft lip with/without cleft palate (CL/P), a complex and heterogeneous birth defect, interferon regulatory factor 6 gene (IRF6) is one of the best documented genetic risk factors...
  36. Matsuzawa N, Kondo S, Shimozato K, Nagao T, Nakano M, Tsuda M, et al. Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome. Am J Med Genet A. 2010;152A:2262-7 pubmed publisher
    Mutations in the interferon regulatory factor 6 gene (IRF6) cause either popliteal pterygium syndrome (PPS) or Van der Woude syndrome (VWS), allelic autosomal dominant orofacial clefting conditions...
  37. Ludwig K, Mangold E, Herms S, Nowak S, Reutter H, Paul A, et al. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet. 2012;44:968-71 pubmed publisher
    ..51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16). ..
  38. Mangold E, Ludwig K, Nothen M. Breakthroughs in the genetics of orofacial clefting. Trends Mol Med. 2011;17:725-33 pubmed publisher
    ..and candidate gene studies have attempted to elucidate the underlying genetic architecture, only the interferon regulatory factor 6 (IRF6) gene has been identified as causative...
  39. Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, et al. Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A. 2011;108:13710-5 pubmed publisher
    The transcription factor interferon regulatory factor 6 (IRF6) regulates craniofacial development and epidermal proliferation...
  40. Shi J, Song T, Jiao X, Qin C, Zhou J. Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population. Biochem Biophys Res Commun. 2011;410:732-6 pubmed publisher
    ..of studies have shown an association between NSCLP and single-nucleotide polymorphisms (SNPs) in the interferon regulatory factor 6 (IRF6) gene in several populations...
  41. Kayano S, Kure S, Suzuki Y, Kanno K, Aoki Y, Kondo S, et al. Novel IRF6 mutations in Japanese patients with Van der Woude syndrome: two missense mutations (R45Q and P396S) and a 17-kb deletion. J Hum Genet. 2003;48:622-8 pubmed
    Three Japanese families with Van der Woude syndrome (VWS) were screened for mutations in the interferon regulatory factor 6 gene (IRF6) by sequencing its entire coding region...
  42. Paranaíba L, Bufalino A, Martelli Junior H, de Barros L, Graner E, Coletta R. Lack of association between IRF6 polymorphisms (rs2235371 and rs642961) and non-syndromic cleft lip and/or palate in a Brazilian population. Oral Dis. 2010;16:193-7 pubmed publisher
    b>Interferon regulatory factor 6 (IRF6) gene has emerged as a potential susceptibility gene for non-syndromic cleft lip and/or palate (NSCL/P) in different populations...
  43. Ali A, Singh S, Raman R. MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. Genet Test Mol Biomarkers. 2009;13:355-60 pubmed publisher
    To determine the association of three SNPs, IRF6 G820A, MTHFR C677T, and MTHFR A1298C, with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in an Indian population...
  44. Lee J, Wang P, Yang I, Huang H, Chang C, Wu C, et al. High-fat diet induces toll-like receptor 4-dependent macrophage/microglial cell activation and retinal impairment. Invest Ophthalmol Vis Sci. 2015;56:3041-50 pubmed publisher
    ..Wild-type C57BL/6 and TLR4 knockout (TLR4KO; B6.B10ScN-Tlr4(lps-del)/JthJ) mice were fed a HFD or control chow diet (CD) for 6 months...
  45. Jo Y, Park H, Choi S, Kim S, Bao C, Kim H, et al. Metabolomic Analysis Reveals Cyanidins in Black Raspberry as Candidates for Suppression of Lipopolysaccharide-Induced Inflammation in Murine Macrophages. J Agric Food Chem. 2015;63:5449-58 pubmed publisher
    ..Both BF3-1 and mixture of these cyanidins at the same ratio reduced lipopolysaccharide (LPS)-induced protein level of iNOS expression and suppressed mRNA and protein expressions of tumor necrosis factor (TNF)..
  46. Liu Q, Li Y, Zhao X, Yang X, Liu Q, Kong Q. Construction of Escherichia coli Mutant with Decreased Endotoxic Activity by Modifying Lipid A Structure. Mar Drugs. 2015;13:3388-406 pubmed publisher
    ..production of recombinant proteins, but these purified proteins are always contaminated with lipopolysaccharide (LPS)...
  47. Bala S, Csak T, Momen Heravi F, Lippai D, Kodys K, Catalano D, et al. Biodistribution and function of extracellular miRNA-155 in mice. Sci Rep. 2015;5:10721 pubmed publisher
    ..In vitro, exosome-mediated restoration of miR-155 in Kupffer cells from miR-155 deficient mice augmented their LPS-induced MCP1 mRNA increase...
  48. Li R, Shen Q, Wu N, He M, Liu N, Huang J, et al. MiR-145 improves macrophage-mediated inflammation through targeting Arf6. Endocrine. 2018;60:73-82 pubmed publisher
    ..12-myristate 13-acetate (PMA) for 48 h to differentiate to macrophages and then were treated with LPS (100 ng/ml) for 8 h to simulate chronic metabolic inflammation in vitro...
  49. Liu G, Li M, Saeed M, Xu Y, Ren Q, Sun C. αMSH inhibits adipose inflammation via reducing FoxOs transcription and blocking Akt/JNK pathway in mice. Oncotarget. 2017;8:47642-47654 pubmed publisher
    ..In this study, we used LPS-induced inflammation model, attempted to interpret the function of αMSH in inflammation and the interactions ..
  50. Xu P, Hong F, Wang J, Cong Y, Dai S, Wang S, et al. Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders. EBioMedicine. 2017;16:251-261 pubmed publisher
    ..tracer technique and polarized light microscopy showed that DLA-M crystals immobilized BODIPY® FL C16 and FITC-LPS, respectively, in the digestive tract in situ...
  51. Soldano A, Alpizar Y, Boonen B, Franco L, Lopez Requena A, Liu G, et al. Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila. elife. 2016;5: pubmed publisher
    ..2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al...
  52. Schwamborn R, Brown E, Haase J. Elevation of cortical serotonin transporter activity upon peripheral immune challenge is regulated independently of p38 mitogen-activated protein kinase activation and transporter phosphorylation. J Neurochem. 2016;137:423-35 pubmed publisher
    ..as one of the molecular targets in inflammation-induced depression, we applied the widely used lipopolysaccharides (LPS) model to study the effects of peripheral inflammation on SERT activity in the brain...
  53. Araki R, Nishida S, Hiraki Y, Li F, Matsumoto K, Yabe T. Kamikihito Ameliorates Lipopolysaccharide-Induced Sickness Behavior via Attenuating Neural Activation, but Not Inflammation, in the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Mice. Biol Pharm Bull. 2016;39:289-94 pubmed publisher
    ..In this study, we examined the effects of KKT on bacterial endotoxin lipopolysaccharide (LPS)-induced sickness behavior in mice...
  54. Nissen T, Birk N, Blok B, Arts R, Andersen A, Kjærgaard J, et al. Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation. A randomized clinical trial. Eur J Clin Microbiol Infect Dis. 2018;37:29-41 pubmed publisher
    ..stimulation) and IFN-?, IL-10, IL-17, IL-22 (96 h stimulation) in response to in vitro stimulation with RPMI, LPS, PHA, Escherichia coli, Streptococcus pneumoniae, Candida albicans and BCG were compared among BCG vaccinated ..
  55. Lang C, Frost R, Jefferson L, Kimball S, Vary T. Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I. Am J Physiol Endocrinol Metab. 2000;278:E1133-43 pubmed
    ..contributing to the inhibition of protein synthesis in skeletal muscle after administration of endotoxin (LPS)...
  56. Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, et al. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Biochem Biophys Res Commun. 2017;493:437-443 pubmed publisher
    The gut-associated lymphoid tissues (GALTs), including Peyer's patches (PPs), cryptopatches (CPs) and isolated lymphoid follicles (ILFs), establish a host-microbe symbiosis by the promotion of immune reactions against gut microbes...
  57. Lyu M, Yan C, Liu H, Wang T, Shi X, Liu J, et al. Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection. Sci Rep. 2017;7:15427 pubmed publisher
    ..Experimentally, DHI exerted comprehensive anti-inflammatory effects on LPS, ox-LDL or cholesterol crystal-induced NF-?B, c-jun and p38 activation, as well as IL-1?, TNF-?, and IL-10 ..
  58. Murdoch A, Patir A, Seymen F, Vieira A. Studies of palatine rugae and interferon regulatory factor 6 variations in a group of families with sporadic hypodontia. J Oral Sci. 2009;51:521-6 pubmed
    Irf6 (interferon regulatory factor 6) is expressed in tooth buds and palatine rugae during development in the mouse...
  59. Cheng Y, Feng Y, Xia Z, Li X, Rong J. ?-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1? and iNOS. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:1595-1605 pubmed publisher
    ..selectively suppressed the up-regulation of inducible nitric oxide synthase (iNOS) over cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages. ?-Alkynyl arachidonic acid also reduced the expression of macrophage M1 biomarkers (e.g...
  60. Ahmad T, Rudd D, Benkendorff K, Mahdi L, Pratt K, Dooley L, et al. Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury. PLoS ONE. 2017;12:e0186904 pubmed publisher
    ..bioactive compound 6-bromoisatin from the Muricidae mollusc Dicathais orbita, for reducing lipopolysaccharide (LPS) induced acute lung inflammation in a mouse model...
  61. Green A, Esser M, Perrot T. Developmental expression of anxiety and depressive behaviours after prenatal predator exposure and early life homecage enhancement. Behav Brain Res. 2018;346:122-136 pubmed publisher
    ..We investigated the impact of a novel repeated prenatal psychological stress (prenatal predator exposure - PPS) during the last week of gestation in rats on offspring behaviours related to social interaction (play behaviour), ..
  62. Lu G, Yu Z, Lu M, Liu D, Wang F, Wu Y, et al. The self-activation and LPS binding activity of executioner caspase-1 in oyster Crassostrea gigas. Dev Comp Immunol. 2017;77:330-339 pubmed publisher
    ..The strong binding activities towards lipopolysaccharide (LPS) of both rCgCaspase-1 and rCgCaspase-1-C were revealed by ELISA techniques and western blotting...
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    ..animals were injected intraperitoneally with one of three doses (10, 50, 100 microg/kg) of lipopolysaccharide (LPS) or vehicle, and blood samples were taken at 15, 30, 60, 90, and 120 min after the injection...