IREB2

Summary

Gene Symbol: IREB2
Description: iron-responsive element binding protein 2
Alias: ACO3, IRP2, IRP2AD, IRE-BP 2, iron regulatory protein 2, iron-responsive element-binding protein 2
Species: human

Top Publications

  1. doi Phylogeny, virulence factors and antimicrobial susceptibility of Escherichia coli isolated in clinical bovine mastitis
    Leena Suojala
    Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, FI 04920 Saarentaus, Finland
    Vet Microbiol 147:383-8. 2011
  2. ncbi Sulfide increases labile iron pool in RD4 cells
    Jonas Hälldin
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    Biometals 21:127-31. 2008
  3. pmc Yersiniabactin production by Pseudomonas syringae and Escherichia coli, and description of a second yersiniabactin locus evolutionary group
    Alain Bultreys
    Département Biotechnologie, Centre Wallon de Recherches Agronomiques, Chaussée de Charleroi 234, B 5030 Gembloux, Belgium
    Appl Environ Microbiol 72:3814-25. 2006
  4. ncbi Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
    T LaVaute
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Genet 27:209-14. 2001
  5. ncbi The molecular features and catalytic activity of CuA-containing aco3-type cytochrome c oxidase from a facultative alkalophilic Bacillus
    I Yumoto
    Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa
    J Biochem 114:88-95. 1993
  6. ncbi Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC
    K J Wu
    Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA an
    Science 283:676-9. 1999
  7. pmc Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
    Dawn L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:493-502. 2009
  8. pmc Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2
    Megumi Ashizuka
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 22:6375-83. 2002
  9. pmc Control of iron homeostasis by an iron-regulated ubiquitin ligase
    Ajay A Vashisht
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 326:718-21. 2009
  10. pmc An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis
    Ameen A Salahudeen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 326:722-6. 2009

Research Grants

Scientific Experts

Detail Information

Publications142 found, 100 shown here

  1. doi Phylogeny, virulence factors and antimicrobial susceptibility of Escherichia coli isolated in clinical bovine mastitis
    Leena Suojala
    Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, FI 04920 Saarentaus, Finland
    Vet Microbiol 147:383-8. 2011
    ..Altogether 56 isolates (38.9%) had at least one virulence gene detected. Most common virulence genes detected were irp2, iucD, papC iss; genes svg, stx1, stx2, cnf1 and hlyA were not found...
  2. ncbi Sulfide increases labile iron pool in RD4 cells
    Jonas Hälldin
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    Biometals 21:127-31. 2008
    ..We have also detected the amounts of L-ferritin protein as well as the iron regulatory protein 2 (IRP2). The sulfide treatment resulted in a 100% increase in the amount of LIP after 1 and 2 h...
  3. pmc Yersiniabactin production by Pseudomonas syringae and Escherichia coli, and description of a second yersiniabactin locus evolutionary group
    Alain Bultreys
    Département Biotechnologie, Centre Wallon de Recherches Agronomiques, Chaussée de Charleroi 234, B 5030 Gembloux, Belgium
    Appl Environ Microbiol 72:3814-25. 2006
    ..HPLC-proven yersiniabactin-producing E. coli lacked modifications found in irp1 and irp2 in the human pathogen CFT073, and it is not clear whether CFT073 produces yersiniabactin...
  4. ncbi Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
    T LaVaute
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Genet 27:209-14. 2001
    ..Here we generate mice with a targeted disruption of the gene encoding Irp2 (Ireb2). These mutant mice misregulate iron metabolism in the intestinal mucosa and the central nervous system...
  5. ncbi The molecular features and catalytic activity of CuA-containing aco3-type cytochrome c oxidase from a facultative alkalophilic Bacillus
    I Yumoto
    Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa
    J Biochem 114:88-95. 1993
    Cytochrome aco3 of Bacillus YN-2000 was purified by an improved procedure and its molecular features and catalytic activity were extensively studied...
  6. ncbi Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC
    K J Wu
    Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA an
    Science 283:676-9. 1999
    ..which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool...
  7. pmc Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
    Dawn L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:493-502. 2009
    ..60 x 10(-5) as a conservative threshold for significance. Three SNPs in the iron regulatory protein 2 (IREB2) gene met this stringent threshold for significance, and four other IREB2 SNPs demonstrated ..
  8. pmc Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2
    Megumi Ashizuka
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 22:6375-83. 2002
    ..screenings to identify partners of this protein; the results showed that YB-1 itself, iron-regulatory protein 2 (IRP2), and five ribosomal proteins each served as partners to YB-1...
  9. pmc Control of iron homeostasis by an iron-regulated ubiquitin ligase
    Ajay A Vashisht
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 326:718-21. 2009
    ..The degradation of iron regulatory protein 2 (IRP2) in iron-replete cells is a key event in this pathway, but the E3 ubiquitin ligase responsible for ..
  10. pmc An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis
    Ameen A Salahudeen
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 326:722-6. 2009
    ..responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2. However, the manner in which iron levels are sensed to affect IRP2 activity is poorly understood...
  11. ncbi Excess capacity of the iron regulatory protein system
    Wei Wang
    Department of Cancer Biology, Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 282:24650-9. 2007
    Iron regulatory proteins (IRP1 and IRP2) are master regulators of cellular iron metabolism...
  12. pmc Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein
    Camille Dycke
    CEA, DSV, iRTSV, Laboratoire de Chimie et Biologie des Metaux, 17 rue des Martyrs, Grenoble F 38054, France
    Biochem J 408:429-39. 2007
    Mammalian IRPs (iron regulatory proteins), IRP1 and IRP2, are cytosolic RNA-binding proteins that post-transcriptionally control the mRNA of proteins involved in storage, transport, and utilization of iron...
  13. pmc HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells
    Kimberly B Zumbrennen
    Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Biochim Biophys Acta 1783:246-52. 2008
    b>Iron regulatory protein 2 (IRP2) binds to iron-responsive elements (IREs) to regulate the translation and stability of mRNAs encoding several proteins involved in mammalian iron homeostasis...
  14. ncbi Oxygen and iron regulation of iron regulatory protein 2
    Eric S Hanson
    Eccles Program in Human Molecular Biology and Genetics and the Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 278:40337-42. 2003
    b>Iron regulatory protein 2 (IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs encoding proteins of iron uptake and storage...
  15. ncbi Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency
    Stefania Recalcati
    Institute of General Pathology, Milano, Italy
    Haematologica 91:303-10. 2006
    The functions of the iron regulatory proteins (IRP1 and IRP2), which control cellular iron homeostasis are similar but not identical...
  16. ncbi A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Blood Cells Mol Dis 27:783-802. 2001
    ..These were further examined for association with differences in iron accumulation as measured by plasma transferrin saturation and ferritin levels, but no such association could be documented...
  17. ncbi Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome
    J R Connor
    Department of Neural and Behavior Sciences, G M Leader Family Laboratory for AD Research, Penn Penn State College of Medicine, Hershey, PA 17033, USA
    Neurology 62:1563-7. 2004
    ..Its etiology is unknown, but MRI analyses and immunohistochemical studies on autopsy tissue suggest the substantia nigra (SN) of patients with RLS has subnormal amounts of iron...
  18. pmc Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice
    Manik C Ghosh
    National Institute of Child Health and Human Development and Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:12028-33. 2008
    ..homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron ..
  19. pmc Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2
    Sharon S Cooperman
    National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Blood 106:1084-91. 2005
    ..Mice with targeted deletion of IRP2 overexpress ferritin and express abnormally low TfR levels in multiple tissues...
  20. pmc Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
    Esther G Meyron-Holtz
    Cell Biology and Metabolism Branch, NIHCD, Bethesda, MD, USA
    EMBO J 23:386-95. 2004
    The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level...
  21. ncbi Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins
    Brad J Niles
    Department of Nutrition, University of California, Davis, California 95616 8669, USA
    J Biol Chem 283:5168-77. 2008
    ..Examination of zinc-deficient cells revealed increased binding of iron regulatory protein 2 (IRP2) and decreased binding of IRP1 to a consensus iron-responsive element...
  22. pmc Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
    Kuanyu Li
    National Institute of Child Health and Human Development, Molecular Medicine Program, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2265-73. 2008
    ..of FA patients have evidence of cytosolic iron depletion, as indicated by increased levels of iron regulatory protein 2 (IRP2) and/or increased IRE-binding activity of IRP1...
  23. doi Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation
    Kiyo aki Ishii
    Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Nat Med 15:259-66. 2009
    ..osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2. TfR1-mediated iron uptake promoted osteoclast differentiation and bone-resorbing activity, associated ..
  24. doi Characterization of the 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase multigene family of Malus domestica Borkh
    Jan E Binnie
    Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    Phytochemistry 70:348-60. 2009
    ..Royal Gala). The genes, designated MD-ACO2 (with an ORF of 990bp) and MD-ACO3 (966bp) have been compared with a previously cloned gene of apple, MD-ACO1 (with an ORF of 942bp)...
  25. pmc Heme induces ubiquitination and degradation of the transcription factor Bach1
    Yukari Zenke-Kawasaki
    Department of Biochemistry, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai, Japan
    Mol Cell Biol 27:6962-71. 2007
    ..HOIL-1, an ubiquitin-protein ligase which recognizes heme-bound, oxidized iron regulatory protein 2, was found to bind with Bach1 when both were overexpressed in NIH 3T3 cells...
  26. ncbi Genotypic and phenotypic heterogeneity of African Americans with primary iron overload
    James C Barton
    Southern Iron Disorders Center, G 105, 20220 Brookwood Medical Center Drive, Birmingham, AL 35209, USA
    Blood Cells Mol Dis 31:310-9. 2003
    ..Abnormal alleles of beta-2 microglobulin, Nramp2, TFR2, hepcidin, or IRP2 alleles were not detected in either of the 2 patients so tested...
  27. pmc Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert
    Carmen Maffettone
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e10163. 2010
    Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression. IRPs may also perform additional functions...
  28. ncbi MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice
    Colette Grabill
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bldg 18T, Room 101 9000 Rockville Pike, Bethesda, MD 20892, USA
    Brain Res 971:95-106. 2003
    Genetic ablation of iron regulatory protein 2 (IRP-2), a protein responsible for post-transcriptional regulation of expression of several iron metabolism proteins, predisposes IRP-2 -/- mice to develop adult onset neurodegenerative ..
  29. ncbi Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
    Bruno Galy
    European Molecular Biology Laboratory, Heidelberg, Germany
    Blood 106:2580-9. 2005
    b>Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-onset neurodegeneration by an unknown mechanism...
  30. doi Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease
    Zhen hua Shi
    Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei Province, China
    Antioxid Redox Signal 13:783-96. 2010
    ..Adult iron-regulatory protein 2 knockout (Ireb2(-/-)) mice develop iron accumulation in white matter tracts and nuclei in different brain area and display severe ..
  31. ncbi Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells
    Alessandra Alberghini
    Institute of General Pathology, University of Milan, Via Mangiagalli 31, 20133 Milan
    J Biol Chem 280:30120-8. 2005
    ..Despite the similarities between HIF-1 and iron regulatory protein 2 (IRP2), we found no evidence of specific regulation of IRP2 by VHL...
  32. ncbi Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice
    Michael F Salvatore
    Department of Anatomy and Neurobiology, The Morris K Udall Parkinson s Disease Research Center of Excellence, 306 Whitney Hendrickson Bldg, 800 Rose Street, Lexington, KY 40536, USA
    Brain Res Mol Brain Res 139:341-7. 2005
    ..Instead, these observations support that the IRP-2 -/- genotype may enable neurobiological events associated with aging...
  33. pmc Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias
    Shino Magaki
    Center for Neurosurgery Research, Loma Linda University, Loma Linda, CA 92350, USA
    Neurosci Lett 418:72-6. 2007
    ..Additionally, the expression of iron regulatory protein 2 (IRP2) was examined in relation to the pathological hallmarks of AD and DLB, amyloid plaques, ..
  34. pmc Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin
    Raymond F Regan
    Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Thompson Building Room 239, Philadelphia, PA 19107, USA
    Neurobiol Dis 31:242-9. 2008
    The effect of iron regulatory protein-2 (IRP2) on ferritin expression and neuronal vulnerability to hemoglobin was assessed in primary cortical cell cultures prepared from wild-type and IRP2 knockout mice...
  35. ncbi Isolation, characterization, and functional studies of rat liver iron regulatory protein 1
    R S Eisenstein
    Department of Nutritional Sciences, University of Wisconsin, Madison 53706, USA
    Arch Biochem Biophys 343:81-91. 1997
    ..translationally regulated by the binding of either of two cytosolic proteins, iron regulatory protein 1 (IRP1) or IRP2, to the iron responsive element (IRE) located in their 5' untranslated region (UTR)...
  36. ncbi Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1
    Marto T Núñez
    Department of Biology, Faculty of Sciences, University of Chile, Casilla 653, Santiago, Chile
    Biometals 16:83-90. 2003
    ..When cells were incubated with up to 20 microM of iron, a typical decrease in IRP1 and IRP2 activity was observed. Interestingly, when iron was further increased to 40 or 80 microM...
  37. ncbi The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins
    Andrew M Thomson
    Laboratory for Cancer Medicine, School of Medicine and Pharmacology, UWA Centre for Medical Research, Western Australian Institute for Medical Research and University of Western Australia, Royal Perth Hospital
    J Biol Chem 280:30032-45. 2005
    ..iron at the level of message translation via a modulated interaction between the iron regulatory proteins (IRP1 and IRP2) and a 5'-untranslated region. Iron-responsive element (IRE)...
  38. doi Responsiveness of Trichomonas vaginalis to iron concentrations: evidence for a post-transcriptional iron regulation by an IRE/IRP-like system
    J C Torres-Romero
    Departamento de Infectómica y Patogénesis Molecular, Centro de Investigacion y de Estudios Avanzados del IPN, Col San Pedro Zacatenco, Mexico City, Mexico
    Infect Genet Evol 9:1065-74. 2009
    ..post-transcriptional level by a well known mechanism mediated by the binding of iron regulatory proteins (IRP1 and IRP2) to hairpin-loop structures, dubbed iron-responsive elements (IREs), localized in the untranslated regions (UTRs) ..
  39. pmc Analysis of nucleotide variations in genes of iron management in patients of Parkinson's disease and other movement disorders
    Emanuela Castiglioni
    Genomic Unit for the Diagnosis of Human Pathologies, Center for Genomics, Bioinformatics and Biostatistics, San Raffaele Scientific Institute, 20132 Milan, Italy
    Parkinsons Dis 2011:827693. 2010
    ..movement disorders, we scanned by DHPLC the exons and intronic boundary regions of ceruloplasmin, iron regulatory protein 2, hemopexin, hepcidin and hemojuvelin genes in cohorts of subjects affected by Parkinson's disease and ..
  40. ncbi Molecular regulation of iron homeostasis and resistance to infection in alcoholics
    Barry J Potter
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Front Biosci 7:d1396-409. 2002
    ..state of knowledge on cellular iron homeostasis, with particular reference to the iron regulatory proteins (IRP1, IRP2 and HFE) and the iron membrane transport proteins, two of which have been shown to be members of the natural ..
  41. doi Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent
    Hong Jiang
    Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines Physiology, Medical College of Qingdao University, Qingdao 266071, China
    Cell Res 20:345-56. 2010
    ..5 cells. In 6-OHDA-treated MES23.5 cells, increased iron regulatory protein (IRP) 1 and IRP2 expression was observed, while silencing of IRPs dramatically diminished 6-OHDA-induced DMT1+IRE up-regulation...
  42. ncbi Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity
    Juliana C Kwok
    The Heart Research Institute, The Iron Metabolism and Chelation Group, Sydney, New South Wales, Australia
    Mol Pharmacol 62:888-900. 2002
    ..of cardiomyocytes was similar to that observed using neoplastic cells, and particularly notable was the decrease in IRP2-RNA-binding activity...
  43. doi Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells
    Shuzhen Zhang
    Department of Physiology, Medical College of Qingdao University, China
    Neurobiol Aging 30:1466-76. 2009
    ..However, there were no changes for iron regulatory protein 1 (IRP1), despite decreased expression of IRP2. Iron itself had no effect on IRP1 and IRP2 expression...
  44. ncbi Structure and expression of three genes encoding ACC oxidase homologs from melon (Cucumis melo L.)
    E Lasserre
    Laboratoire Ethylène et Mécanismes Moléculaires de la Maturation des Fruits UA INRA, Ecole Nationale Superieure Agronomique de Toulouse, France
    Mol Gen Genet 251:81-90. 1996
    ..The other two genes (CM-ACO2, CM-ACO3) have only two introns, at positions identical to their counterparts in CM-ACO1...
  45. pmc The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation
    C Pelludat
    Max von Pettenkofer Institut für Medizinische Mikrobiologie und Hygiene, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Bacteriol 180:538-46. 1998
    ..These genes constitute the yersiniabactin biosynthetic gene cluster together with the previously defined irp2. The irp1 gene consists of 9,486 bp capable of encoding a 3,161-amino-acid high-molecular-weight protein 1 (HMWP1) ..
  46. pmc The functional duality of iron regulatory protein 1
    Karl Volz
    Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612 7344, USA
    Curr Opin Struct Biol 18:106-11. 2008
    Iron homeostasis in animal cells is controlled post-transcriptionally by the iron regulatory proteins IRP1 and IRP2. IRP1 can assume two different functions in the cell, depending on conditions...
  47. ncbi The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins
    Julie Bayle
    INSERM UMR599, Laboratoire d Hématopoïèse Moléculaire et Fonctionnelle, Marseille, France
    FEBS Lett 580:2609-14. 2006
    ..Here, we show that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), another E3 ubiquitin ligase, interacts with SOCS6...
  48. ncbi IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice
    Gianfranca Corna
    Institute of General Pathology, University of Milan, Via Mangiagalli 31, Milan 20133, Italy
    J Mol Med (Berl) 84:551-60. 2006
    ..DOX exposure elicits a differential modulation of the two IRPs with reduced IRP2 activity and unchanged IRP1 activity...
  49. ncbi Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2
    Koji Yamanaka
    Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 5:336-40. 2003
    ..b>Iron regulatory protein 2 (IRP2), a modulator of iron metabolism, is regulated by iron-induced ubiquitination and degradation...
  50. ncbi A siderophore biosynthesis gene cluster from the fish pathogen Photobacterium damselae subsp. piscicida is structurally and functionally related to the Yersinia high-pathogenicity island
    Carlos R Osorio
    Department of Microbiology and Parasitology, Institute of Aquaculture and Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela 15782, Galicia, Spain
    Microbiology 152:3327-41. 2006
    ..DNA region of 35 kb was identified in strain DI21, and 11 genes were defined: dahP, araC1, araC2, frpA, irp8, irp2, irp1, irp3, irp4, irp9 and irp5...
  51. pmc Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity
    Jian Wang
    Lady Davis Institute for Medical Research, Sir Mortimer B, Davis Jewish General Hospital, Montreal, Quebec, Canada
    BMC Mol Biol 9:15. 2008
    b>Iron regulatory protein 2 (IRP2), a post-transcriptional regulator of cellular iron metabolism, undergoes iron-dependent degradation via the ubiquitin-proteasome pathway...
  52. pmc Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans
    Helen M Hansen
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 19:3652-61. 2010
    ..A haplotype and its tagging single nucleotide polymorphisms (SNPs) encompassing six genes from IREB2 to CHRNB4 were most strongly associated with lung cancer risk (OR = 1.3; P < 10(-20))...
  53. pmc Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
    Hong Ye
    Molecular Medicine Program, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 120:1749-61. 2010
    ..element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and increased IRP2 levels, indicative of relative cytosolic iron depletion, were observed together with mitochondrial iron overload...
  54. pmc High-molecular-weight protein 2 of Yersinia enterocolitica is homologous to AngR of Vibrio anguillarum and belongs to a family of proteins involved in nonribosomal peptide synthesis
    I Guilvout
    Unité de bactériologie moléculaire et médicale, Institut Pasteur, Paris, France
    J Bacteriol 175:5488-504. 1993
    The iron-regulated irp2 gene is specific for the highly pathogenic Yersinia species and encodes high-molecular-weight protein 2 (HMWP2)...
  55. pmc HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis
    Yuxi Shan
    School of Veterinary Medicine, Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
    Hum Mol Genet 21:1457-69. 2012
    ..cytosolic and mitochondrial iron pools and increased the expression of transferrin receptor 1 and iron regulatory protein 2 consistent with decreased iron bioavailability...
  56. ncbi Familial keratoconus with cataract: linkage to the long arm of chromosome 15 and exclusion of candidate genes
    Anne E Hughes
    Department of Medical Genetics, Queen s University, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland, U K
    Invest Ophthalmol Vis Sci 44:5063-6. 2003
    ..Uniquely, in this family both disorders were present and fully penetrant in those affected...
  57. pmc Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism
    Peijun Zhang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20817, USA
    J Struct Biol 150:144-53. 2005
    Previous studies have shown that IRP1(+/-) IRP2(-/-) knockout mice develop progressive neurodegenerative symptoms similar to those observed in human movement disorders such as Parkinson's disease...
  58. pmc Aging-related changes in the iron status of skeletal muscle
    Keith C DeRuisseau
    Department of Exercise Science, Syracuse University, 820 Comstock Ave, Room 201 WB, Syracuse, NY 13244, USA Electronic address
    Exp Gerontol 48:1294-302. 2013
    ..TfR1), storage (ferritin), export (ferroportin; FPN), and regulation (iron regulatory protein-1 (IRP1) and -2 (IRP2)) of male F344xBN F1 rats (n=10/group) of various ages (8, 18, 28, 32, and 36 months) to further understand iron ..
  59. pmc Nitrogen monoxide-mediated control of ferritin synthesis: implications for macrophage iron homeostasis
    Sangwon Kim
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Physiology, McGill University, 3755 Cote Sainte Catherine Road, Montreal, QC, Canada H3T 1E2
    Proc Natl Acad Sci U S A 99:12214-9. 2002
    Intracellular iron homeostasis is regulated posttranscriptionally by iron regulatory proteins 1 and 2 (IRP1 and IRP2)...
  60. ncbi Functional interaction between nitric oxide-induced iron homeostasis and heme oxygenase-1 in immortalized and malignant oral keratinocytes
    Sun Kyung Lee
    Department of Oral and Maxillofacial Pathology, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 570 749, Republic of Korea
    Cancer Lett 249:283-93. 2007
    ..The roles of the caspase pathway, of regulatory proteins of iron metabolism (iron regulatory protein (IRP)1, IRP2, transferrin receptor (TfR), and ferritin), and of HO-1 in protection against NO-induced cytotoxicity were assessed...
  61. ncbi Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide
    Marc Mikhael
    Department of Physiology, McGill University, Montreal, Canada
    FEBS J 273:3828-36. 2006
    The discovery of iron-responsive elements (IREs), along with the identification of iron regulatory proteins (IRP1, IRP2), has provided a molecular basis for our current understanding of the remarkable post-transcriptional regulation of ..
  62. pmc Nitric oxide inhibits the degradation of IRP2
    Jian Wang
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Rd, Montreal, Quebec H3T 1E2, Canada
    Mol Cell Biol 25:1347-53. 2005
    Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia...
  63. pmc Association of Pro-Inflammatory Cytokines and Iron Regulatory Protein 2 (IRP2) with Leishmania Burden in Canine Visceral Leishmaniasis
    Paulo Ricardo Porfírio do Nascimento
    Department of Biochemistry, BioScience Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
    PLoS ONE 8:e73873. 2013
    ..The expression of IFN-γ, TNF-α, IL-10 and Iron Regulatory Protein 2 (IRP2) were determined in the spleen by quantitative PCR. Sera cytokines were evaluated by ELISA...
  64. pmc Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide
    Agnieszka Styś
    Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Wolka Kosowska, Poland
    J Biol Chem 286:22846-54. 2011
    ..IRP1 is a bifunctional protein that mostly exists in a non-IRE-binding, [4Fe-4S] cluster aconitase form, whereas IRP2, which does not assemble an Fe-S cluster, spontaneously binds IREs...
  65. ncbi Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain
    Asha Jyothi M Siddappa
    Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    J Neurosci Res 68:761-75. 2002
    ..IRP and transport protein expression increased in parallel over time. IRP1, IRP2, and DMT-1 were partially expressed in the choroid plexus epithelial cells at PND 5 and 10, and fully expressed at ..
  66. pmc Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1
    Marc A Kerenyi
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria
    Blood 112:3878-88. 2008
    ..This reduction could be attributed to reduced transcription of TfR-1 mRNA and iron regulatory protein 2 (IRP-2), the major translational regulator of TfR-1 mRNA stability in erythroid cells...
  67. ncbi Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1
    Kazuhiro Iwai
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, and Japan Science and Technology Agency, Osaka 545 8585, Japan
    Methods Enzymol 398:256-71. 2005
    ..Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (IRP2), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger ..
  68. doi A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration
    Xu Ping Li
    Parkinson Disease Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurosignals 20:223-36. 2012
    ..We documented that IRP2 disruption resulted in an increase in transferrin receptor 1 (TfR1), a decrease in ferritin heavy chain (H-Frt), ..
  69. ncbi Virulence-associated traits in avian Escherichia coli: comparison between isolates from colibacillosis-affected and clinically healthy layer flocks
    D Vandekerchove
    Department of Bacteriology and Immunology, Veterinary and Agrochemical Research Centre, Groeselenberg 99, Brussel 1180, Belgium
    Vet Microbiol 108:75-87. 2005
    ..were significantly more often detected in the outbreak isolates than in the control isolates: tsh, iss, iucA, iutA, irp2, fyuA, iroC, cvaC, colicin and colicin V production...
  70. pmc Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility
    Mateusz Siedlinski
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Genet 132:431-41. 2013
    ..Simultaneous analysis of modestly (r (2) = 0.21) linked markers in CHRNA3 and IREB2 revealed that an even larger (~42%) proportion of the total effect of the CHRNA3 locus on COPD was mediated by ..
  71. pmc Adhesion of human and animal Escherichia coli strains in association with their virulence-associated genes and phylogenetic origins
    Ulrike Frömmel
    Brandenburgische Technische Universität Cottbus Senftenberg, Senftenberg, Germany
    Appl Environ Microbiol 79:5814-29. 2013
    ..a higher rate of adhesion to one or more cell lines: afa-dra, daaD, tsh, vat, ibeA, fyuA, mat, sfa-foc, malX, pic, irp2, and papC. In summary, we established new screening methods which enabled us to characterize large numbers of E...
  72. doi Surgical trauma induces iron accumulation and oxidative stress in a rodent model of postoperative cognitive dysfunction
    Li na An
    Anesthesia and Operation Center, Chinese PLA General Hospital, Haidian District, Beijing, China
    Biol Trace Elem Res 151:277-83. 2013
    ..involved in the maintenance of brain iron homeostasis, including ferritin, transferrin receptor 1, and iron regulatory protein 2, were significantly different at postoperative days 1 and 3 in the hippocampus of splenectomized animals ..
  73. doi IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation
    Nicole Wilkinson
    Lady Davis Institute for Medical Research, Jewish General Hospital, and Department of Medicine, McGill University, Montreal, QC, Canada
    Blood 122:1658-68. 2013
    ..mechanism for translational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respectively)...
  74. ncbi Isolation and characterization of a potato cDNA corresponding to a 1-aminocyclopropane-1-carboxylate (ACC) oxidase gene differentially activated by stress
    Maria Eugenia Zanetti
    Instituto de Investigaciones Biológicas Departamento de Biología, Universidad Nacional de Mar del Plata, Funes 3250, CC 1245, 7600 Mar del Plata, Argentina
    J Exp Bot 53:2455-7. 2002
    ..A cDNA clone encoding an ACC oxidase, ST-ACO3, was isolated from potato (Solanum tuberosum L...
  75. doi Genetic modification of iron metabolism in mice affects the gut microbiota
    Keren Buhnik-Rosenblau
    Department of Biotechnolgy and Food Engineering, Technion Israel Institute of Technology, 32000, Technion, Haifa, Israel
    Biometals 25:883-92. 2012
    ..The iron regulatory protein 2 (Irp2) and one of the genes mutated in hereditary hemochromatosis Hfe , are both proteins involved in ..
  76. pmc Pathotyping avian pathogenic Escherichia coli strains in Korea
    Yong Wun Jeong
    Laboratory of Avian Diseases, College of Veterinary Medicine and BK21 for Veterinary Science, Seoul National University, Seoul 151 742, Korea
    J Vet Sci 13:145-52. 2012
    ..The virulence genes we tested included ones encoding type 1 fimbriae (fimC), iron uptake-related (iroN, irp2, iucD, and fyuA), toxins (lt, st, stx1, stx2, and vat), and other factors (tsh, hlyF, ompT, and iss)...
  77. doi HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues
    Hillel Zukor
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Neurochem 109:776-91. 2009
    ..and sulfur within many cytopathological profiles without impacting ferroportin, transferrin receptor, ferritin, and IRP2 protein levels or IRP1 activity...
  78. pmc Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis
    Yanbo Shi
    National Institute of Child Health and Human Development, Molecular Medicine Program, Bethesda, MD 20892, USA
    Hum Mol Genet 18:3014-25. 2009
    ..iron-responsive element-binding activity of iron regulatory protein 1, increased protein levels of iron regulatory protein 2, and resulted in abnormal punctate ferric iron accumulations in cells...
  79. doi The frequency of molecular detection of virulence genes encoding cytolysin A, high-pathogenicity island and cytolethal distending toxin of Escherichia coli in cases of sudden infant death syndrome does not differ from that in other infant deaths and healt
    Amanda R Highet
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Med Microbiol 58:285-9. 2009
    ..and 101 dead control and healthy infants for three new candidate pathogenicity-related genes: clyA (cytolysin A), irp2 [high-pathogenicity island (HPI)-specific gene] and cdt (cytolethal distending toxin)...
  80. doi In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation
    Lydie Viatte
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    J Mol Med (Berl) 87:913-21. 2009
    ..To explore the role of IRP1 and IRP2 in inflammation, IRP-deficient mice, i.e...
  81. pmc A novel streptococcal integrative conjugative element involved in iron acquisition
    Zoe Heather
    Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK
    Mol Microbiol 70:1274-92. 2008
    ..Deletion of eqbA resulted in a small-colony phenotype. Further deletion of the irp2 homologue eqbE, or the genes eqbH, eqbI and eqbJ encoding a putative ABC transporter, or addition of the iron ..
  82. ncbi Demonstration and characterization of the iron regulatory protein in human brain
    J Hu
    Department of Neuroscience and Anatomy, Penn State University College of Medicine, M S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Neurochem 67:838-44. 1996
    ..Two IRPs (IRP1 and IRP2) have been reported...
  83. doi Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk
    Felicia S Falvella
    Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 15:1837-42. 2009
    ....
  84. pmc Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2
    Kimberly B Zumbrennen
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell Biol 29:2219-29. 2009
    b>Iron regulatory protein 2 (IRP2) is an RNA-binding protein that regulates the posttranscriptional expression of proteins required for iron homeostasis such as ferritin and transferrin receptor 1...
  85. doi Iron regulatory protein 2 is involved in brain copper homeostasis
    Claudius Mueller
    Neurosurgery Center for Research, Training and Education, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    J Alzheimers Dis 18:201-10. 2009
    ..we have therefore compared brain regional copper levels and AbetaPP expression in mice with a targeted deletion of IRP2-/-...
  86. pmc Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease
    Deepinder Kaur
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Brain Res 1297:17-22. 2009
    ..A similar age-related neurodegeneration has been reported in iron regulatory protein 2-deficient (IRP2 -/-) mice coinciding with increased ferritin levels within degenerating neurons...
  87. ncbi An iron-clad role for proteasomal degradation
    Nancy C Andrews
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA
    Cell Metab 14:281-2. 2011
    ..In this issue of Cell Metabolism, Moroishi and colleagues (2011) show that FBXL5, an iron sensor in an ubiquitin ligase complex, keeps cellular iron in balance by promoting the degradation of IRP2 in vivo.
  88. doi The embryo lethality of Escherichia coli isolates and its relationship to the presence of virulence-associated genes
    J Y Oh
    Animal, Plant and Fisheries Quarantine and Inspection Agency, Anyang, Kyunggi, Korea
    Poult Sci 91:370-5. 2012
    ..from visceral organs of chickens with colibacillosis for the presence of 9 virulence genes (fimC, tsh, fyuA, irp2, iucD, cvi/cva, iss, astA, and vat) by PCR...
  89. ncbi Nitrosative and oxidative modulation of iron regulatory proteins
    C Bouton
    Institut de Chimie des Substances Naturelles, Gif sur Yvette Cedex, France
    Cell Mol Life Sci 55:1043-53. 1999
    ..Iron regulatory proteins (IRP1 and IRP2), two post-transcriptional regulators of gene expression, are particularly sensitive to NO synthesis and to ..
  90. pmc From grazing resistance to pathogenesis: the coincidental evolution of virulence factors
    Sandrine Adiba
    Laboratoire d Ecologie, CNRS UMR7625, Universite Pierre et Marie Curie, Paris Universitas, Paris, France
    PLoS ONE 5:e11882. 2010
    ..coli collection faced to the grazing of D. discoideum. E. coli strains carrying virulence genes such as iroN, irp2, fyuA involved in iron uptake, belonging to the B2 phylogenetic group and being virulent in a mouse model of ..
  91. pmc Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1
    Hyun Hee Cho
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 285:31217-32. 2010
    ..Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation of the ferritin subunits...
  92. pmc Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage
    Mai Chen
    Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Philadelphia, PA 19107, USA
    Brain Res 1337:95-103. 2010
    ..In order to assess the therapeutic potential of this approach after striatal ICH, the effect of IRP1 or IRP2 gene knockout on ferritin expression and injury was quantified...
  93. pmc The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study
    Sally L Chappell
    The University of Nottingham, School of Molecular Medical Sciences, University Hospital, Queens Medical Centre, Nottingham, UK
    BMC Med Genet 12:24. 2011
    ..association studies in combination with expression profiling have identified a number of new candidates including IREB2. A meta-analysis has implicated transforming growth factor beta-1 (TGFbeta1) as a contributor to disease ..
  94. ncbi Mammalian iron metabolism
    Luis G Valerio
    U S Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, Division of Biotechnology and GRAS Notice Review, College Park, MD, 20470, USA
    Toxicol Mech Methods 17:497-517. 2007
    ..In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of ..
  95. pmc Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery
    Daniel R Crooks
    Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA
    Blood 115:860-9. 2010
    ..We investigated ferrochelatase expression in iron-deficient erythropoietic tissues of mice lacking iron regulatory protein 2, in iron-deficient murine erythroleukemia cells, and in human patients with ISCU myopathy...
  96. doi A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome
    Wei Cao
    Cell Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland
    Blood Cells Mol Dis 44:22-7. 2010
    ..post-transcriptional negative feedback exerted by the interaction between iron regulatory proteins 1, 2 (IRP1 and IRP2) and IRE, which leads to uncontrolled expression of L-ferritin...
  97. ncbi Virulence-associated fyuA/irp2 gene cluster of Yersinia enterocolitica biotype 1B carries a novel insertion sequence IS1328
    A Rakin
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Germany
    FEMS Microbiol Lett 129:287-92. 1995
    The fyuA/irp2 gene cluster, which is part of the Yersinia pestis pigmentation (pgm) locus encoding genes involved in iron uptake and virulence, is present in all pesticin-sensitive bacteria. In Y...
  98. ncbi [Regulating action of iron regulatory protein-2 in iron metabolism of lung cancer]
    Zhe Cheng
    Department of Respiratory Medicine, Zhengzhou University, Zhengzhou, China
    Zhonghua Yi Xue Za Zhi 91:1992-5. 2011
    To discuss the regulating mechanism of iron regulatory protein-2 (IRP2) in the iron metabolism of lung cancer.
  99. ncbi Hereditary causes of disturbed iron homeostasis in the central nervous system
    Prem Ponka
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Physiology and Medicine, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1012:267-81. 2004
    ..Mice with a targeted disruption of a gene for iron regulatory protein 2 (IRP2), a translational repressor of ferritin, misregulate iron metabolism in the intestinal mucosa and ..
  100. ncbi Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
    Robert R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    J Inorg Biochem 91:9-18. 2002
    ..Current views on cellular iron homeostasis involving the iron regulatory proteins IRP1 and IRP2 and their interactions with the iron regulatory elements, affecting either mRNA translation (ferritin and erythroid ..
  101. pmc Regional dissection and determination of loosely bound and non-heme iron in the developing mouse brain
    Shino Magaki
    Neurosurgery Center for Research, Training and Education, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Brain Res 1158:144-50. 2007
    ..We examined 6, 12, and 24 week old wildtype C57BL/6 mice and mice with a targeted deletion of iron regulatory protein 2 (IRP2-/-) that have been reported to develop neurodegenerative symptoms in adulthood...

Research Grants77

  1. HYPOXIC REGULATION OF IRON REGULATORY PROTEIN 2 (IRP2)
    Eric Hanson; Fiscal Year: 2003
    ..The RNA binding iron regulatory protein 2 (IRP2), an important post-transcriptional regulator, was recently found to be regulates by hypoxia by a ..
  2. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2010
    ..b>Iron regulatory protein 2 (IRP2) is a key regulator of cellular iron metabolism...
  3. Study of an iron-responsive E3 ligase regulating mammalian iron homeostasis
    Richard K Bruick; Fiscal Year: 2010
    ..is high, IRP1 assembles an iron-sulfur cluster, causing the protein to lose its affinity for IREs, while IRP2 is preferentially ubiquitinated and degraded by the proteasome...
  4. Iron Metabolism Alterations in Alzheimer's Disease
    Wolff Kirsch; Fiscal Year: 2006
    ..A genetically engineered mouse with an iron regulatory protein 2 "knockout" that accumulates abnormal quantities of brain iron and displays a neurodegenerative disorder ..
  5. NOVEL BIOCHEMICAL ROLES FOR IRON REGULATORY PROTEIN 2
    ELIZABETH LEIBOLD; Fiscal Year: 2006
    ..Mammals have therefore evolved complex regulatory mechanisms devoted to iron homeostasis, where iron regulatory protein 2 (IRP2) serves a critical function...
  6. REGULATION OF IRON METABOLISM GENES IN EUKARYOTES
    WILLIAM WALDEN; Fiscal Year: 2005
    ..There are two IRP family members, called IRP1 and IRP2. IRP1 is a bifunctional protein having the aforementioned activity as a RNA binding, gene regulator, or as the ..
  7. Alteration of host iron homeostasis by Neisseria
    ROBERT BONNAH; Fiscal Year: 2005
    ..The other key host iron homeostasis proteins, ferritin, iron regulatory protein-1 (IRP1) and IRP2 levels and biological activity will also be monitored during the course of GC infection...
  8. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH LEIBOLD; Fiscal Year: 2003
    ..Iron regulatory proteins 1 and 2 (IRP1 and 2) are key proteins involved in cellular iron homeostasis. IRP1 and IRP2 are cytosolic RNA binding proteins that regulate the translation or the stability of mRNAs encoding proteins ..
  9. Structure and Function of Iron Regulatory Proteins
    Karl Volz; Fiscal Year: 2007
    ..and storage in animal cells is regulated post-transcriptionally by two iron regulatory proteins, IRP1 and IRP2. The IRPs reversibly bind to highly conserved stem-loop structures known as iron responsive elements (IREs) in the ..
  10. Structure and Function of Iron Regulatory Proteins
    KARL W VOLZ; Fiscal Year: 2010
    ..and storage in animal cells is regulated post-transcriptionally by two iron regulatory proteins, IRP1 and IRP2. The IRPs reversibly bind to highly conserved stem-loop structures known as iron responsive elements (IREs) in the ..
  11. FERRITIN, ISO-IRES AND IRON IN VITRO AND IN CELLS
    Elizabeth Theil; Fiscal Year: 2002
    ..of IRE subdomains of ferritin synthesis, mRNA stability, Tm (+/- metals) and nuclease cleavage related to IRP1/IRP2 binding in vitro and in vivo 2...
  12. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH LEIBOLD; Fiscal Year: 1999
    ..Cellular iron homeostasis is regulated by the iron- regulatory proteins 1 and 2 (IRP1 and IRP2)...
  13. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2010
    ..Our goal is to determine the mechanisms by which the iron-regulatory proteins 1 and 2 (IRP1 and IRP2) control iron homeostasis...
  14. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH LEIBOLD; Fiscal Year: 2007
    ..Our goal is to determine the mechanisms by which the iron-regulatory proteins 1 and 2 (IRP1 and IRP2) control iron homeostasis...
  15. Fe, O2, mRNA and Ferritin in Vitro & in Cells
    Elizabeth Theil; Fiscal Year: 2007
    ..We showed that IRP2/IRE selectivity required specific IRE stem structure that was H+ sensitive and bound Mg++ in ferritin mRNA, and was ..
  16. Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5
    JAMES AKIRA WOHLSCHLEGEL; Fiscal Year: 2010
    ..In specific aim 1, we will examine the molecular basis of the iron-regulated interaction of FBXL5 with IRP2, a key regulator of iron homeostasis...
  17. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2007
    ..Mammalian iron metabolism is modulated by two regulatory RNA binding proteins, iron regulatory protein 1 (IRP1) and IRP2. IRPs bind to iron responsive elements (IRE) in up to seven different mRNA encoding proteins critical for the ..
  18. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2009
    ..Mammalian iron metabolism is modulated by two regulatory RNA binding proteins, iron regulatory protein 1 (IRP1) and IRP2. IRPs bind to iron responsive elements (IRE) in up to seven different mRNA encoding proteins critical for the ..
  19. Biological Function of Iron Responsive Elements
    RICHARD EISENSTEIN; Fiscal Year: 2009
    ..a single IRE in their 5' untranslated region allowing iron-dependent control of mRNA translation by IRP1 and IRP2. Dysregulation of IRP or the mRNA targets of IRP action, such as the heme formation enzyme erythroid 5'..
  20. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond Regan; Fiscal Year: 2009
    ..Cell ferritin levels are primarily regulated by iron regulatory proteins (IRP1 and IRP2), which bind to an iron responsive element (IRE) in the 5'-untranslated region of its mRNA and repress ..
  21. IRON METABOLISM AND PHOSPHORYLATION OF IRPS BY PKC
    RICHARD EISENSTEIN; Fiscal Year: 2002
    ..is modulated through the action of two regulatory RNA binding proteins, iron regulatory protein 1 (IRP1) and IRP2. IRPs bind to iron responsive elements (IRE) in ferritin (iron storage) and transferrin receptor (TfR) (iron uptake)..
  22. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond Regan; Fiscal Year: 2007
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  23. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  24. Optimizing Heme Oxygenase Activity after CNS Hemorrhage
    Raymond Regan; Fiscal Year: 2009
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  25. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond Regan; Fiscal Year: 2009
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  26. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond Regan; Fiscal Year: 2006
    ..Surrounding neuronal loss, DNA cleavage, and caspase-3 activation will then be quantified at defined time points 12-96 hours after injection. ..
  27. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond Regan; Fiscal Year: 2003
    ..Surrounding neuronal loss, DNA cleavage, and caspase-3 activation will then be quantified at defined time points 12-96 hours after injection. ..
  28. Optimizing Heme Oxygenase Activity after CNS Hemorrhage
    Raymond Regan; Fiscal Year: 2007
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  29. Structure and Function of Iron Regulatory Proteins
    Karl Volz; Fiscal Year: 2009
    ..and storage in animal cells is regulated post-transcriptionally by two iron regulatory proteins, IRP1 and IRP2. The IRPs reversibly bind to highly conserved stem-loop structures known as iron responsive elements (IREs) in the ..
  30. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..
  31. Genetic Analysis of Iron Homeostasis in C. elegans
    ELIZABETH LEIBOLD; Fiscal Year: 2007
    ..elegans using a green fluorescence protein (GFP)-based screen. ..