IRAS

Summary

Gene Symbol: IRAS
Description: nischarin
Alias: IR1, IRAS, hIRAS, I-1 receptor candidate protein, I1R candidate protein, imidazoline receptor 1, imidazoline receptor antisera selected
Species: human

Top Publications

  1. ncbi Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera
    T R Ivanov
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Auton Nerv Syst 72:98-110. 1998
  2. ncbi Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228 3900, USA
    Circulation 107:2422-7. 2003
  3. ncbi Nitrite and nitrate formation on model NO(x) storage materials: on the influence of particle size and composition
    A Desikusumastuti
    , , Egerlandstr 3, D 91058, Erlangen, Germany
    Phys Chem Chem Phys 11:2514-24. 2009
  4. doi Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype
    I F Nagtzaam
    Department of Dermatology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Br J Dermatol 163:205-7. 2010
  5. ncbi Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
  6. ncbi Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease
    Smail Hadj-Rabia
    Département de génétique, Hopital Necker Enfants Malades, Paris, France
    Gastroenterology 127:1386-90. 2004
  7. doi Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors
    Fei Li
    Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China
    Eur J Pharmacol 612:1-8. 2009
  8. ncbi Evaluation for an observation effect in a prospective cohort study of oral health outcomes
    G H Gilbert
    Claude D Pepper Center for Research on Oral Health in Aging, College of Dentistry, University of Florida, Gainesville 32610 0416, USA
    Community Dent Oral Epidemiol 26:233-40. 1998
  9. pmc Association of plasma vitamin D levels with adiposity in Hispanic and African Americans
    Kendra A Young
    Colorado School of Public Health, University of Colorado Denver, 13001 East 17th Place, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3306-13. 2009
  10. ncbi Dietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Br J Nutr 92:973-84. 2004

Research Grants

  1. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
  2. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
  3. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
  4. IRAS FAMILY STUDY: GENETICS OF INSULIN RESISTANCE
    Michael Bryer Ash; Fiscal Year: 2003
  5. IRAS FAMILY STUDY: GENETICS OF INSULIN RESISTANCE
    Mohammed Saad; Fiscal Year: 2002
  6. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
  7. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
  8. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
  9. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Steven Haffner; Fiscal Year: 2007
  10. Genetics of Adiposity and Glucose Homeostastis
    Michael Bryer Ash; Fiscal Year: 2007

Detail Information

Publications128 found, 100 shown here

  1. ncbi Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera
    T R Ivanov
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Auton Nerv Syst 72:98-110. 1998
    ..In situ hybridization histochemistry revealed an enrichment of the message in neuronal cell bodies of the rat hippocampus and cerebellar cortex. This clone has some of the properties expected of an imidazoline receptor...
  2. ncbi Promoter (4G/5G) plasminogen activator inhibitor-1 genotype and plasminogen activator inhibitor-1 levels in blacks, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78228 3900, USA
    Circulation 107:2422-7. 2003
    ..The 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene has been related to cardiovascular disease...
  3. ncbi Nitrite and nitrate formation on model NO(x) storage materials: on the influence of particle size and composition
    A Desikusumastuti
    , , Egerlandstr 3, D 91058, Erlangen, Germany
    Phys Chem Chem Phys 11:2514-24. 2009
    ..has been investigated by molecular beam (MB) methods and time-resolved IR reflection absorption spectroscopy (TR-IRAS) in combination with structural characterization by scanning tunneling microscopy (STM)...
  4. doi Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype
    I F Nagtzaam
    Department of Dermatology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Br J Dermatol 163:205-7. 2010
    ..Although the two conditions cannot always be easily distinguished, we would suggest that paucity of bile ducts could be a manifestation of NISCh...
  5. ncbi Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
    ..To determine the meaning of S(i) = 0 derived from the frequently sampled intravenous glucose tolerance test...
  6. ncbi Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease
    Smail Hadj-Rabia
    Département de génétique, Hopital Necker Enfants Malades, Paris, France
    Gastroenterology 127:1386-90. 2004
    ..We considered claudin-1 to be a strong candidate gene based on its mapping to the minimum interval and on the expression pattern of the mouse ortholog...
  7. doi Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors
    Fei Li
    Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China
    Eur J Pharmacol 612:1-8. 2009
    ..Chinese hamster ovary cells co-expressing mu opioid receptor and imidazoline receptor antisera-selected protein (IRAS), the strong candidate for imidazoline I(1) receptor, were used as the cell line...
  8. ncbi Evaluation for an observation effect in a prospective cohort study of oral health outcomes
    G H Gilbert
    Claude D Pepper Center for Research on Oral Health in Aging, College of Dentistry, University of Florida, Gainesville 32610 0416, USA
    Community Dent Oral Epidemiol 26:233-40. 1998
    ..their typical approach to dental care as stated at baseline: consistent regular attenders (CRAs); inconsistent regular attenders (IRAs); consistent problem-oriented attenders (CPOAs); and inconsistent problem-oriented attenders (IPOAs).
  9. pmc Association of plasma vitamin D levels with adiposity in Hispanic and African Americans
    Kendra A Young
    Colorado School of Public Health, University of Colorado Denver, 13001 East 17th Place, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3306-13. 2009
    ....
  10. ncbi Dietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Br J Nutr 92:973-84. 2004
    ..insulin sensitivity (SI) and adiposity in the multi-ethnic, multi-centre Insulin Resistance Atherosclerosis Study (IRAS, 1992-94)...
  11. ncbi Active Surfaces for CO Oxidation on Palladium in the Hyperactive State
    Mingshu Chen
    State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers Esters, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China
    Langmuir 26:18113-8. 2010
    ..at the hyperactive state for palladium were characterized using infrared reflection absorption spectroscopy (IRAS, 450-4000 cm(-1)) under the realistic catalytic reaction condition...
  12. ncbi Imidazoline receptors, novel agents and therapeutic potential
    G A Head
    P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Cardiovasc Hematol Agents Med Chem 4:17-32. 2006
    ..Interestingly, an I(1)- receptor candidate has been cloned (IRAS, imidazoline receptor antisera selected) which is a homologue of the mouse cell adhesion integrin binding protein Nischarin...
  13. doi Not the next IRA: how health savings accounts shape public opinion
    Jason Barabas
    Florida State University, USA
    J Health Polit Policy Law 34:181-217. 2009
    ..Statistical analyses show that owners of Individual Retirement Accounts (IRAs) and Health Savings Accounts (HSAs) experience policy feedback effects, but in opposite directions...
  14. pmc Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose
    D Il'yasova
    Department of Community and Family Medicine, Prevention Research Division, Duke University Medical Center, Box 2949, Durham, NC, 27710, USA
    Diabetologia 53:866-74. 2010
    ..To examine this assumption, we used cohort data from the Insulin Resistance Atherosclerosis Study (IRAS).
  15. doi Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family study
    A J G Hanley
    Department of Nutritional Sciences, University of Toronto, ON, Canada
    Diabetologia 52:2079-86. 2009
    ..Our objective was to study the association of directly measured visceral and subcutaneous adipose tissue (VAT, SAT), insulin sensitivity (S (I)) and the acute insulin response (AIR) with incident type 2 diabetes...
  16. ncbi Treatment of instent restenosis following stent-supported renal artery angioplasty
    Thomas Zeller
    Department of Angiology, Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Catheter Cardiovasc Interv 70:454-9. 2007
    We prospectively studied the long-term outcome of endovascular treatment of instent renal artery stenosis (IRAS).
  17. ncbi Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ..subjects has been carried out in African-American (n = 21) and Hispanic (n = 45) extended families as part of the IRAS Family Study...
  18. ncbi Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study
    Mohammed F Saad
    Division of Clinical Epidemiology, Department of Medicine, UCLA Medical School, 924 Westwood Blvd, Suite 335 Mail Box 15, Los Angeles, Calif 90024, USA
    Hypertension 43:1324-31. 2004
    ..505 Hispanics (H), and 413 African Americans (AA) who participated in the Insulin Resistance Atherosclerosis Study (IRAS)...
  19. ncbi Defibrase, a purified fibrinolytic protease from snake venom in acute myocardial infarction
    D X Huang
    Department of Cardiology, P L A General Hospital, Beijing, P R China
    Acta Cardiol 47:445-58. 1992
    ..v. defibrase thrombolysis, 6 were shown to have patent IRAs. Of the 16 pts who underwent coronary arteriography two weeks after the i.v...
  20. ncbi Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome)
    Simone C Zimmerli
    Division of Immunology and Allergy, Department of Internal Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland
    Exp Dermatol 17:20-3. 2008
    ..Our findings do not exclude a role of this TJ molecule once Langerhans cells have left the epidermis for draining lymph nodes...
  21. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  22. ncbi The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ..of PP in three studies, the Diabetes Heart Study (DHS), the Insulin Resistance Atherosclerosis Family Study (IRAS FS), and the NHLBI Family Heart Study (FHS), to estimate the residual heritability after inclusion of a common set ..
  23. pmc Sleep duration and five-year abdominal fat accumulation in a minority cohort: the IRAS family study
    Kristen G Hairston
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Sleep 33:289-95. 2010
    ..To study 5-year change in computed tomography (CT)-derived visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) associated with sleep duration in 2 minority groups...
  24. ncbi Cosegregation of albuminuria and blood pressure: the Insulin Resistance Atherosclerosis (IRAS) family study
    Xiuqing Guo
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Hypertens 18:823-7. 2005
    ..Our aim in this study was to examine the familial aggregation of albuminuria and its phenotypic, genetic, and environmental correlations with BP in nondiabetic individuals of Hispanic (HA) and African American (AA) ethnicity...
  25. pmc Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study
    Jill M Norris
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 17:1932-41. 2009
    ..Several candidate loci, including RGS6 and NGEF, are associated with CT-derived adipose fat measures in Hispanic Americans in a three-stage genetic association study...
  26. pmc INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study
    Matthew E Talbert
    Program in Molecular Medicine and Translational Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 17:1554-62. 2009
    ..Trending association after multiple comparisons adjustment remains suggestive of a role for genetic variation of INSIG2 in obesity, but these results require validation...
  27. ncbi Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obes Res 13:1491-8. 2005
    ..These results support the hypothesis that POMC contributes genetically to the development of obesity...
  28. pmc Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:4979-83. 2008
    ..2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addressed the physiological impact of variants in Hispanic-Americans and African-Americans carefully phenotyped for components of glucose homeostasis...
  29. ncbi Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 53:3013-9. 2004
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein...
  30. ncbi Insulin secretion, obesity, and potential behavioral influences: results from the Insulin Resistance Atherosclerosis Study (IRAS)
    E J Mayer-Davis
    School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC 29208, USA
    Diabetes Metab Res Rev 17:137-45. 2001
    ..This work was conducted to evaluate associations of insulin secretion with overall and central obesity, dietary fats, physical activity, and alcohol...
  31. ncbi Microalbuminuria and carotid artery intima-media thickness in nondiabetic and NIDDM subjects. The Insulin Resistance Atherosclerosis Study (IRAS)
    L Mykkanen
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284 7873, USA
    Stroke 28:1710-6. 1997
    ..We investigated the relationship between microalbuminuria and carotid artery IMT in 991 nondiabetic and 450 NIDDM subjects aged 40 to 69 years...
  32. ncbi Utility of a surrogate measure of insulin resistance in American Indians: the Strong Heart Study
    Helaine E Resnick
    MedStar Research Institute, Washington, DC, USA
    Ethn Dis 12:523-9. 2002
    ..assessment (HOMA) model; (2) compare insulin sensitivity in a sample of diabetic and non-diabetic Al in the Strong Heart Study (SHS) with that of White, Black, and Hispanic Americans in the Insulin Resistance Atherosclerosis Study (IRAS).
  33. ncbi Protein adsorption on mixtures of hydroxyl- and methyl-terminated alkanethiols self-assembled monolayers
    Ma Cristina L Martins
    Instituto de Engenharia Biomedica, Laboratorio de Biomateriais, and Departmento de Engenharia Metalúrgica e Materias, Universidade do Porto, Porto, Portugal
    J Biomed Mater Res A 67:158-71. 2003
    ..spectroscopy, water contact angles, and Fourier transform infrared reflection absorption spectroscopy (IRAS)...
  34. ncbi Major racial differences in coronary constrictor response between japanese and caucasians with recent myocardial infarction
    C Pristipino
    Universita Cattolica del S Cuore, Rome, Italy
    Circulation 101:1102-8. 2000
    ..Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial...
  35. ncbi [Functional genome analysis investigating resistance to respiratory tract disease in a porcine Actinobacillus pleuropneumoniae infection model]
    T Rehm
    Zentrum für Infektionsmedizin, Institut für Mikrobiologie der Stiftung Tierärztliche Hochschule Hannover
    Dtsch Tierarztl Wochenschr 115:260-4. 2008
    Here we present the work of the multidisciplinary consortium IRAS (Development of Genetic Markers for Immune Defence and Resistance in the Porcine Respiratory Tract) which includes different commercial and research institutions and was ..
  36. ncbi High-resolution experimental phases for tryptophanyl-tRNA synthetase (TrpRS) complexed with tryptophanyl-5'AMP
    P Retailleau
    Department of Biochemistry and Biophysics, CB 7260, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Acta Crystallogr D Biol Crystallogr 57:1595-608. 2001
    ..densities for, respectively, peak-wavelength SAD data from four different crystals, MAD data and their M(S)IRAS combinations with native data...
  37. ncbi Relationship of admission haematological indices with infarct-related artery patency in patients with acute ST-segment elevation myocardial infarction treated with primary angioplasty
    Orhan Maden
    Cardiology Department, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
    Coron Artery Dis 18:639-44. 2007
    ..We aimed to evaluate the value of admission MPV and WBC-C for the prediction of IRA patency, in patients with acute STEMI treated with primary percutaneous coronary intervention...
  38. ncbi Specific reactivity of step sites towards CO adsorption and oxidation on platinum single crystals vicinal to Pt(111)
    Qing Song Chen
    Institute of Electrochemistry, University of Alicante, E 03080 Alicante, Spain
    Phys Chem Chem Phys 12:11407-16. 2010
    ..This was confirmed by in situ infrared reflection-absorption spectroscopy (IRAS) studies, showing that the (110) step sites are dominated by atop CO while bridged bonded CO are prevalent on (100) ..
  39. doi Intercalibration of infrared channels of polar-orbiting IRAS/FY-3A with AIRS/Aqua data
    Geng Ming Jiang
    Key Laboratory of Wave Scattering and Remote Sensing Information Ministry of Education, Fudan University, Shanghai 200433, PR China
    Opt Express 18:3358-63. 2010
    ..47 microm), 9 (11.11 microm) and 19 (3.98 microm) of the InfraRed Atmospheric Sounder (IRAS) aboard the Chinese second generation polar-orbiting meteorological satellite FengYun 3A (FY-3A) with high spectral ..
  40. ncbi The circumstellar environment of IRAS 05338-0624
    J P McMullin
    Astronomy Dept, University of Maryland, College Park 20742, USA
    Astrophys J 437:305-16. 1994
    ..and 60" resolution are used to characterize the structure and chemistry of the gas around the young, embedded star, IRAS 05338-0624...
  41. ncbi CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists
    Frank Boeckler
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052 Erlangen, Germany
    J Med Chem 48:2493-508. 2005
    ..726 and 0.590, respectively, when a newly invented program application (IRAS) controlling the alignment selection proved to be useful...
  42. ncbi Structure and desorption energetics of ultrathin D2O ice overlayers on serine- and serinephosphate-terminated self-assembled monolayers
    Mattias Ostblom
    Division of Molecular Physics, Department of Physics, Chemistry, and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    J Phys Chem B 110:1695-700. 2006
    ..SAMs at approximately 85 K in ultrahigh vacuum and characterized with infrared reflection absorption spectroscopy (IRAS). Reflection absorption (RA) spectra obtained at sub-monolayer D2O coverage reveal that surface modes, e.g...
  43. doi The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS)
    C C Lee
    Department of Nutritional Sciences, Fitzgerald Building, University of Toronto, 150 College St, Toronto, ON, Canada M5S 3E2
    Diabetologia 56:112-20. 2013
    ..We examined the association between plasminogen activator inhibitor (PAI)-1, C-reactive protein (CRP), TNF-α, leptin and fibrinogen and the progression of metabolic clearance rate of insulin (MCRI) over time...
  44. ncbi Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 55:911-8. 2006
    ..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region...
  45. doi Effects of O2 pressure on the oxidation of VO(x)/Pt(111)
    Zhenyan Tang
    State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China
    Phys Chem Chem Phys 15:12124-31. 2013
    ..spectroscopy (LEIS), Auger electron spectroscopy (AES), and in situ infrared reflection absorption spectroscopy (IRAS)...
  46. ncbi Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor
    Ning Wu
    Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China
    Eur J Pharmacol 548:21-8. 2006
    The present study investigated the effects of agmatine action on imidazoline I1 receptor antisera-selected protein (IRAS), a candidate for imidazoline I1 receptor, on prolonged morphine-induced adaptations of calcium signal and long-..
  47. doi Site-specific and covalent attachment of his-tagged proteins by chelation assisted photoimmobilization: a strategy for microarraying of protein ligands
    Emma M Ericsson
    Division of Molecular Physics, Division of Organic Chemistry, and Division of Applied Physics Department of Physics, Chemistry and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Langmuir 29:11687-94. 2013
    ..SAMs) were prepared on gold and thoroughly characterized by infrared reflection absorption spectroscopy (IRAS), ellipsometry, and contact angle goniometry...
  48. ncbi Photoinduced surface dynamics of CO adsorbed on a platinum electrode
    Hidenori Noguchi
    J Phys Chem B 110:15055-8. 2006
    ..with potential by approximately 33 cm(-1)/V, as previously found in an infrared reflection absorption spectroscopy (IRAS) study...
  49. doi A simulation framework for estimating wall stress distribution of abdominal aortic aneurysm
    Jing Qin
    Department of Mechanical Engineering, National University of Singapore
    Conf Proc IEEE Eng Med Biol Soc 2011:900-3. 2011
    ..of non-stented/stented AAA based on fluid-structure interaction, which is utilized in a surgical simulation system (IRAS). The 3D geometric model of AAA is reconstructed from computed tomography angiographic (CTA) images...
  50. ncbi Structural characterization of microcontact printed arrays of hexa(ethylene glycol)-terminated alkanethiols on gold
    Ye Zhou
    S SENCE and Division of Sensor Science and Molecular Physics, Linkoping University, S 581 83 Linkoping, Sweden
    Langmuir 20:6206-15. 2004
    ..Microwetting, contact angle goniometry, imaging null ellipsometry, and infrared reflection-absorption spectroscopy (IRAS) are used to characterize the printed EG6 layers, and the quality of these layers in terms of layer thickness and ..
  51. ncbi Interaction of CO and deuterium with bimetallic, monolayer Pt-island/film covered Ru(0001) surfaces
    H Hartmann
    Institute of Surface Chemistry and Catalysis, Ulm University, D 89069 Ulm, Germany
    Phys Chem Chem Phys 14:10919-34. 2012
    ..Additionally, the adsorption of CO was investigated by infrared reflection absorption spectroscopy (IRAS)...
  52. doi Infrared spectroelectrochemical study of dissociation and oxidation of methanol at a palladium electrode in alkaline solution
    Yao Yue Yang
    Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China
    Langmuir 29:1709-16. 2013
    ..The former (ATR-SEIRAS) has a higher sensitivity of detecting surface species, and the latter (IRAS) can easily detect dissolved species trapped in a thin-layer-structured electrolyte...
  53. ncbi Effect of postmortem delay on imidazoline receptor-binding proteins in human and mouse brain
    John K Ma
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:341-6. 2003
    ..immunoreactive bands of similar size have been suggested to be breakdown products of the 170-kD protein known as IRAS (putative full-length I(1) receptor)...
  54. pmc Fish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS)
    C Lee
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Nutr Metab Cardiovasc Dis 23:829-35. 2013
    ..Therefore, we examined the association of fish consumption with measures of insulin sensitivity and beta-cell function in a multi-ethnic population...
  55. ncbi Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study
    B S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 30:1433-41. 2006
    ..In the IRAS Family Study a genomewide scan was performed on 1425 individuals of Hispanic descent (90 extended pedigree families)..
  56. ncbi On the structure and desorption dynamics of DNA bases adsorbed on gold: a temperature-programmed study
    Mattias Ostblom
    Division of Molecular Physics, Department of Physics, Chemistry and Biology, Linkoping University, S 581 83 Linkoping, Sweden
    J Phys Chem B 109:15150-60. 2005
    ..thin films are studied using temperature-programmed desorption-infrared reflection absorption spectroscopy (TPD-IRAS) and temperature-programmed desorption-mass spectroscopy (TPD-MS)...
  57. ncbi Accuracy of IRAS GT interferometer and potential acuity meter prediction of visual acuity after phacoemulsification: prospective comparative study
    Cécile Le Sage
    Service d Ophtalmologie, CMC Gui de Chauliac, Montpellier, France
    J Cataract Refract Surg 28:131-8. 2002
    ..To assess and compare the accuracy of 2 methods of predicting visual acuity after phacoemulsification...
  58. pmc KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses
    Semra Demokan
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 127:2351-9. 2010
    ..Promoter hypermethylation of KIF1A and EDNRB is a frequent event in primary HNSCC, and these genes are preferentially methylated in salivary rinses from HNSCC patients. KIF1A and EDNRB are potential biomarkers for HNSCC detection...
  59. pmc Cross-sectional and longitudinal changes of glucose effectiveness in relation to glucose tolerance: the insulin resistance atherosclerosis study
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, TX, USA
    Diabetes Care 34:1959-64. 2011
    ....
  60. doi Reaction kinetics and polarization modulation infrared reflection absorption spectroscopy investigations of CO oxidation over planar Pt-group model catalysts
    Feng Gao
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, Texas 77842 3012, USA
    Langmuir 26:16540-51. 2010
    ..review recent work in our laboratory, using polarization modulation infrared reflection absorption spectroscopy (PM-IRAS) and reaction kinetics measurements from ultrahigh vacuum to near-atmospheric pressures...
  61. pmc Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    J Steroid Biochem Mol Biol 122:186-92. 2010
    ..01). In conclusion, we identified several SNPs that were associated with vitamin D metabolite concentrations in Hispanics. These candidate polymorphisms merit further investigation in independent populations and other ethnicities...
  62. pmc Five-year change in visceral adipose tissue quantity in a minority cohort: the Insulin Resistance Atherosclerosis Study (IRAS) family study
    Kristen G Hairston
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 32:1553-5. 2009
    ..05 for both). Similar trends have been observed in men. CONCLUSIONS Accumulation of abdominal fat is greatest in young adulthood. These data may be useful in identifying subgroups at risk of type 2 diabetes...
  63. pmc Impact of National Clinical Guideline recommendations for revascularization of persistently occluded infarct-related arteries on clinical practice in the United States
    Marc W Deyell
    Division of Cardiology, University of British Columbia, Vancouver, Canada
    Arch Intern Med 171:1636-43. 2011
    ..The purpose of this study was to determine the impact of OAT results and consequent change in guideline recommendations for PCI for treatment of persistently occluded IRAs.
  64. ncbi NISCH syndrome with hypothyroxinemia
    Ira Shah
    Pediatric Hepatobiliary Clinic B J Wadia Hospital for Children
    Ann Hepatol 9:299-301. 2010
    ..Only 5 patients have been described till now. We report a patient presenting with clinical characteristics of NISCH syndrome and hypothyroxinemia...
  65. pmc Disposition index, glucose effectiveness, and conversion to type 2 diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes Care 33:2098-103. 2010
    ..Disposition index (DI) and glucose effectiveness (S(G)) are risk factors for diabetes. However, the effect of DI and S(G) on future diabetes has not been examined in large epidemiological studies using direct measures...
  66. pmc Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    Iris M Heid
    Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany
    Nat Genet 42:949-60. 2010
    ..9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions...
  67. ncbi Reactions of NO2 with BaO/Pt(111) model catalysts: the effects of BaO film thickness and NO2 pressure on the formation of Ba(NOx)2 species
    Kumudu Mudiyanselage
    Institute for Interfacial Catalysis, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Phys Chem Chem Phys 13:11016-26. 2011
    ..desorption (TPD), X-ray photoelectron spectroscopy (XPS), and infrared reflection absorption spectroscopy (IRAS) under ultra-high vacuum (UHV) as well as elevated pressure conditions...
  68. pmc Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study
    N D Palmer
    Department of Biochemistry, Centers for Human Genomics and Diabetes Research, Wake Forest University School of Medicine, 1 Medical Center Blvd, Winston Salem, NC 27157, USA
    Diabetologia 53:281-9. 2010
    ....
  69. pmc Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
    Maria R Wing
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 125:615-26. 2009
    ..038 and 0.058). These results confirm that FTO variants are associated with adiposity measures, predisposing individuals to obesity by increasing overall fat mass in Hispanic Americans and to a lesser degree in African Americans...
  70. ncbi Dewetting growth of crystalline water ice on a hydrogen saturated Rh(111) surface at 135 K
    Atsushi Beniya
    The Institute for Solid State Physics, The University of Tokyo, Kashiwa, Chiba, Japan
    J Chem Phys 135:054702. 2011
    ..Rh(111) surface using temperature programmed desorption and infrared reflection absorption spectroscopy (IRAS) in ultrahigh vacuum. With increasing the hydrogen coverage, the desorption temperature of water decreases...
  71. pmc Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 17:1240-6. 2009
    ..Hispanic American and 347 African-American adults participating in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study...
  72. doi Saccharide-functionalized alkanethiols for fouling-resistant self-assembled monolayers: synthesis, monolayer properties, and antifouling behavior
    Timmy Fyrner
    Division of Chemistry, IFM, Linkoping University, SE 581 83 Linkoping, Sweden
    Langmuir 27:15034-47. 2011
    ..SAMs were characterized using ellipsometry, wetting measurements, and infrared reflection-absorption spectroscopy (IRAS)...
  73. doi Toward ionic-liquid-based model catalysis: growth, orientation, conformation, and interaction mechanism of the [Tf2N]- anion in [BMIM][Tf2N] thin films on a well-ordered alumina surface
    Marek Sobota
    Lehrstuhl fur Physikalische Chemie II, Friedrich Alexander Universitat Erlangen Nurnberg, Egerlandstr 3, 91058 Erlangen, Germany
    Langmuir 26:7199-207. 2010
    ..We apply infrared reflection absorption spectroscopy (IRAS) in combination with density functional theory (DFT)...
  74. ncbi Resonance Raman and surface- and tip-enhanced Raman spectroscopy methods to study solid catalysts and heterogeneous catalytic reactions
    Hacksung Kim
    Department of Chemistry, Center for Catalysis and Surface Science, and Institute for Catalysis and Energy Processes, Northwestern University, Evanston, Illinois 60208, USA
    Chem Soc Rev 39:4820-44. 2010
    ..of so-called Raman (fluorescence) background, detection limits for RR compared to other techniques (EXAFS, PM-IRAS, SFG), and three well-known methods to assign UV-vis absorption bands and a band-specific unified method that is ..
  75. ncbi Soft- and Reactive-Landing of Cr(aniline)(2) Sandwich Complexes onto Self-Assembled Monolayers: Separation between Functional and Binding Sites
    Shuhei Nagaoka
    Department of Chemistry, Faculty of Science and Technology, Keio University, 3 14 1 Hiyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    J Am Chem Soc 133:18719-27. 2011
    ..Cr(aniline)(2) complexes on the SAM surfaces were characterized using infrared reflection absorption spectroscopy (IRAS) and temperature-programmed desorption (TPD), together with theoretical calculations based on density functional ..
  76. ncbi NMR identifies atherogenic lipoprotein abnormalities in early diabetic nephropathy that are unrecognized by conventional analysis
    H Z Al-Shahrouri
    Division of Clinical Nephrology Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Clin Nephrol 73:180-9. 2010
    ..The aim of this study was to investigate the relationship between lipoproteins and early manifestations of CKD in the 517 Type 2 diabetes mellitus (T2DM) patients who participated in the Insulin Resistance Atherosclerosis Study (IRAS).
  77. doi Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)
    R C Loopstra-Masters
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building, 150 College St, Toronto, ON, Canada
    Diabetologia 54:3047-54. 2011
    ..The objective of this paper was to compare fasting intact and split proinsulin-to-insulin ratios (PI/I, SPI/I) with intact and split proinsulin-to-C-peptide ratios (PI/C-pep, SPI/C-pep) in the prediction of type 2 diabetes...
  78. doi Variant in the 3' region of the IkappaBalpha gene associated with insulin resistance in Hispanic Americans: The IRAS Family Study
    Melissa R Miller
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA
    Obesity (Silver Spring) 18:555-62. 2010
    ..NFKBIA and S(I) in 981 individuals in 90 Hispanic-American families from the Insulin Resistance Atherosclerosis (IRAS) Family Study...
  79. ncbi Adsorption and reaction of NO on the clean and nitrogen modified Rh(111) surfaces
    Atsushi Beniya
    The Institute for Solid State Physics, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba 277 8581, Japan
    J Chem Phys 131:084704. 2009
    ..modified Rh(111) surfaces were investigated between 20 and 150 K using infrared reflection adsorption spectroscopy (IRAS) and temperature programmed desorption...
  80. pmc Generation and characterization of novel human IRAS monoclonal antibodies
    Bo Wang
    Department of Pharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
    J Biomed Biotechnol 2009:973754. 2009
    ..the functional and structure properties of I1R, we developed the newly monoclonal antibody against the N-terminal hIRAS region including the PX domain (10-120aa) through immunization of BALB/c mice with the NusA-IRAS fusion protein ..
  81. ncbi Two-dimensional superstructures and softened C-H stretching vibrations of cyclohexane on Rh(111): effects of preadsorbed hydrogen
    Takanori Koitaya
    The Institute for Solid State Physics, The University of Tokyo, 5 1 5, Kashiwanoha, Kashiwa, Chiba 277 8581, Japan
    J Chem Phys 135:234704. 2011
    ..electron diffraction, temperature-programmed desorption, and infrared reflection absorption spectroscopy (IRAS)...
  82. doi Dehydrogenation of dodecahydro-N-ethylcarbazole on Pd/Al2O3 model catalysts
    Marek Sobota
    Physical Chemistry 2, Department of Chemistry and Pharmacy, University Erlangen Nuremberg, Egerlandstr 3, 91058 Erlangen, Germany
    Chemistry 17:11542-52. 2011
    ..Adsorption and thermally induced surface reactions were followed by infrared reflection absorption spectroscopy (IRAS) and high-resolution X-ray photoelectron spectroscopy (HR-XPS) in combination with density functional theory (DFT) ..
  83. pmc Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Physiol Behav 105:138-44. 2011
    ..and behavioral plasticity following lentivirus-mediated downregulation of hypothalamic insulin receptors (hypo-IRAS). Hypo-IRAS rats exhibit increases in body weight, adiposity, plasma leptin and triglyceride levels...
  84. ncbi Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS)
    L E Wagenknecht
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
    Stroke 28:999-1005. 1997
    ..Diabetes is a major risk factor for morbidity and mortality from cardiovascular disease. However, the role of the primary metabolic abnormality of diabetes (chronic hyperglycemia) in this disease process has not been fully elucidated...
  85. ncbi Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I(1)-receptor action
    I F Musgrave
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia
    Ann N Y Acad Sci 1009:413-8. 2003
    b>IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif...
  86. ncbi IRAS is an anti-apoptotic protein
    Monique Dontenwill
    Pharmacologie et Physicochimie des Interactions Cellulaires et Moléculaires, UMR CNRS 7034, Faculte de Pharmacie, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Ann N Y Acad Sci 1009:400-12. 2003
    ..The amino acid sequence of human IRAS (hIRAS) is unrelated to known proteins, except for rat IRAS and a mouse homologue named nischarin, which binds the alpha5 ..
  87. ncbi Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study
    Latha Palaniappan
    Stanford University Medical Center, Stanford, California 94305 5705, USA
    Diabetes Care 27:788-93. 2004
    ..To prospectively investigate predictors of the incident metabolic syndrome in nondiabetic adults...
  88. ncbi Complex organic matter in space: about the chemical composition of carriers of the Unidentified Infrared Bands (UIBs) and protoplanetary emission spectra recorded from certain astrophysical objects
    Franco Cataldo
    Società Lupi Chemical Research Institute, Via Casilina 1626 A, 00133 Rome, Italy
    Orig Life Evol Biosph 34:13-24. 2004
    ..proposal is based on the comparison between the emission spectra recorded from the protoplanetary nebulae (PPNe) IRAS 22272+ 5435 and the infrared absorption spectra of certain 'heavy' petroleum fractions...
  89. ncbi Site-specific progression of carotid artery intimal-medial thickness
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 171:137-43. 2003
    ..To characterize the intercorrelation of changes in intimal-medial thickness (IMT) among carotid artery sites and examine the influence of diabetes and sex on these correlations...
  90. ncbi Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
    ..previously measured insulin action in a large cohort of subjects (Insulin Resistance and Atherosclerosis Study [IRAS] Family Study) using the minimal model approach...
  91. ncbi Tyrosine derivatives assembled on gold
    Kajsa Uvdal
    Laboratory of Applied Physics, Linkoping University, S 581 83 Linkoping, Sweden
    J Colloid Interface Sci 260:361-6. 2003
    ..are studied by means of X-ray photoelectron spectroscopy (XPS) and infrared reflection-absorption spectroscopy (IRAS)...
  92. ncbi Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods
    Leora Henkin
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 13:211-7. 2003
    ..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and ..
  93. ncbi The intracrine hypothesis and intracellular peptide hormone action
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 99 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Bioessays 25:401-9. 2003
    ..The intracellular/intracrine renin-angiotensin system (iRAS) is reviewed to illustrate the intracrine analogue of a well-established physiological system...
  94. ncbi Insulin sensitivity and the risk of incident hypertension: insights from the Insulin Resistance Atherosclerosis Study
    David C Goff
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes Care 26:805-9. 2003
    ..Previous studies have documented cross-sectional associations between insulin sensitivity (S(I)) and blood pressure or prevalent hypertension. Prospective data have been sparse...
  95. ncbi Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: The Insulin Resistance and Atherosclerosis Study (IRAS)
    Elizabeth J Mayer-Davis
    Department of Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina, Columbia 29208, USA
    Diabetes Care 25:2172-7. 2002
    ..To evaluate the association of vitamin E with incidence of type 2 diabetes and to do so separately among individuals who did and those who did not report regular use of vitamin supplementation...
  96. ncbi Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
    ..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
  97. ncbi Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA
    H Sheng
    Department of Surgery, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 275:6628-35. 2000
    ..RIE-1 cells were transfected with an inducible Ha-Ras(Val12) cDNA and are referred as RIE-iRas cells...
  98. ncbi Suppression and enhancement of distortion-product otoacoustic emissions by interference tones above f(2). I. Basic findings in rabbits
    G K Martin
    Department of Otolaryngology M805, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101 6960, USA
    Hear Res 136:105-23. 1999
    The present study measured interference-response areas (IRAs) for distortion-product otoacoustic emissions (DPOAEs) at 2f(1)-f(2), 3f(1)-2f(2), and 2f(2)-f(1)...
  99. ncbi Imidazoline receptor antisera-selected cDNA clone and mRNA distribution
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 881:1-7. 1999
    A novel cDNA, designated Imidazoline Receptor Antisera-Selected cDNA-1 (iras-1), encodes a 167-kD protein. Two of its predicted peptides (42-43 kD) are immunologically consistent with a previously reported 1(1)-imidazoline binding protein...
  100. ncbi Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, TX 78284 7873, USA
    Arterioscler Thromb Vasc Biol 19:562-8. 1999
    ..These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic...
  101. ncbi Ability of alternative indices of insulin sensitivity to predict cardiovascular risk: comparison with the "minimal model". Insulin Resistance Atherosclerosis Study (IRAS) Investigators
    G Howard
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC, USA
    Ann Epidemiol 8:358-69. 1998
    ..This report evaluates previously described alternative indices of insulin sensitivity with the goal of identifying a reliable, but logistically simpler, alternative...

Research Grants90

  1. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  2. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  3. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  4. IRAS FAMILY STUDY: GENETICS OF INSULIN RESISTANCE
    Michael Bryer Ash; Fiscal Year: 2003
    ..and Hispanic men and women who are currently participating in the Insulin Resistance Atherosclerosis Study (IRAS). Approximately 1280 family members will be recruited...
  5. IRAS FAMILY STUDY: GENETICS OF INSULIN RESISTANCE
    Mohammed Saad; Fiscal Year: 2002
    ..and Hispanic men and women who are currently participating in the Insulin Resistance Atherosclerosis Study (IRAS). Approximately 1280 family members will be recruited...
  6. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  7. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..The Insulin Resistance and Atherosclerosis Study (IRAS) is a cohort study supported by the National Heart Lung and Blood Institute...
  8. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ..prospective studies that have evaluated late percutaneous transluminal coronary angioplasty (PTCA) of occluded IRAs after AMI have produced conflicting results...
  9. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Steven Haffner; Fiscal Year: 2007
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  10. Genetics of Adiposity and Glucose Homeostastis
    Michael Bryer Ash; Fiscal Year: 2007
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  11. Molecular genetics of glucose homeostasis and fat
    Donald Bowden; Fiscal Year: 2005
    ..The IRAS Family Study is a multicenter project designed to study the genetic epidemiology of insulin resistance and ..
  12. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Jill Norris; Fiscal Year: 2009
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  13. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Jill Norris; Fiscal Year: 2003
    ..of African-American and Hispanic background who are participating in the Insulin Resistance Atherosclerosis Study (IRAS), including 54 Hispanic families in our center...
  14. Genetic & Epidemiologic Predictors of Glucose Homeostasis Measures in Hispanics
    Richard M Watanabe; Fiscal Year: 2010
    ..In the IRAS Family Study (funded for two five-year cycles by NHLBI), we have recruited a large Hispanic cohort and obtained ..
  15. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Richard Bergman; Fiscal Year: 2003
    ..The organization of this study will be similar to that of IRAS, with three clinical centers, a coordinating center, a central laboratory and a genetic laboratory...
  16. SLEEP-DISORDERED BREATHING & THE METABOLIC SYNDROME
    Mohammed Saad; Fiscal Year: 2003
    ..cohort of African American families participating in the Insulin Resistance Atherosclerosis Family Study (IRAS Family Study), an ongoing study funded by NHLBI...
  17. Genetic Determinants of Visceral Adiposity
    Yongmei Liu; Fiscal Year: 2010
    ..Study of Atherosclerosis (MESA, 787 EAs, 411 AAs A), and the Insulin Resistance Atherosclerosis Family Study (IRAS, 600 AAs), will be used to further validate those SNPs (probably 10-15) replicated in FHS or JHS...
  18. Urinary F2-isoprostanes as a new biomarker for the risk of type 2 diabetes
    DORA ILYASOVA; Fiscal Year: 2010
    ..We propose to expand our pilot study to the entire eligible IRAS cohort (n=900)...
  19. Urinary F2-isoprostanes as a new biomarker for the risk of type 2 diabetes
    DORA ILYASOVA; Fiscal Year: 2009
    ..We propose to expand our pilot study to the entire eligible IRAS cohort (n=900)...
  20. Spatial epidemiology of diabetes in the SEARCH for Diabetes in Youth Study
    ANGELA LIESE; Fiscal Year: 2009
    ..This effort may provide novel leads for subsequent etiologic studies of pediatric diabetes and will assist health care planners in identifying geographic areas in particular need of health services resources. ..
  21. Spatial epidemiology of diabetes in the SEARCH for Diabetes in Youth Study
    ANGELA LIESE; Fiscal Year: 2007
    ..This effort may provide novel leads for subsequent etiologic studies of pediatric diabetes and will assist health care planners in identifying geographic areas in particular need of health services resources. ..
  22. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...
  23. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2003
    ..of African-American and Hispanic background using participants of the Insulin Resistance Atherosclerosis Study (IRAS) as index cases...
  24. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
    The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis...