IQGAP1

Summary

Gene Symbol: IQGAP1
Description: IQ motif containing GTPase activating protein 1
Alias: HUMORFA01, SAR1, p195, ras GTPase-activating-like protein IQGAP1, RasGAP-like with IQ motifs
Species: human
Products:     IQGAP1

Top Publications

  1. White C, Khurana H, Gnatenko D, Li Z, Odze R, Sacks D, et al. IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC Gastroenterol. 2010;10:125 pubmed publisher
    b>IQGAP1 and IQGAP2 are homologous members of the IQGAP family of scaffold proteins. Accumulating evidence implicates IQGAPs in tumorigenesis...
  2. Ren J, Li Z, Sacks D. IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci U S A. 2007;104:10465-9 pubmed
    b>IQGAP1 modulates several cellular functions, including cell-cell adhesion, transcription, cytoskeletal architecture, and selected signaling pathways...
  3. Liu Z, Liu D, Bojdani E, El Naggar A, Vasko V, Xing M. IQGAP1 plays an important role in the invasiveness of thyroid cancer. Clin Cancer Res. 2010;16:6009-18 pubmed publisher
    This study was designed to explore the role of IQGAP1 in the invasiveness of thyroid cancer and its potential as a novel prognostic marker and therapeutic target in this cancer...
  4. Sakurai Yageta M, Recchi C, Le Dez G, Sibarita J, Daviet L, Camonis J, et al. The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol. 2008;181:985-98 pubmed publisher
    ..We demonstrate that the exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation...
  5. Li Z, Kim S, Higgins J, Brenner M, Sacks D. IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem. 1999;274:37885-92 pubmed
    ..b>IQGAP1, a novel RasGAP-related protein that interacts with the cytoskeleton, binds to actin, members of the Rho family, ..
  6. Goto T, Sato A, Shimizu M, Adachi S, Satoh K, Iemura S, et al. IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS ONE. 2013;8:e60865 pubmed publisher
    ..In the present study, we identified IQGAP1 as a regulator of DVL function...
  7. Pelikan Conchaudron A, Le Clainche C, Didry D, Carlier M. The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration. J Biol Chem. 2011;286:35119-28 pubmed publisher
    b>IQGAP1 is a large modular protein that displays multiple partnership and is thought to act as a scaffold in coupling cell signaling to the actin and microtubule cytoskeletons in cell migration, adhesion, and cytokinesis...
  8. McCallum S, Wu W, Cerione R. Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. J Biol Chem. 1996;271:21732-7 pubmed
    ..Microsequencing of a p180 peptide revealed 92% identity with the human IQGAP1 protein, while two peptides derived from p175 were 89 and 100% identical to human IQGAP2...
  9. Roy M, Li Z, Sacks D. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol. 2005;25:7940-52 pubmed
    b>IQGAP1 modulates many cellular functions such as cell-cell adhesion, transcription, cytoskeletal architecture, and selected signaling pathways...

More Information

Publications67

  1. Nabeshima K, Shimao Y, Inoue T, Koono M. Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett. 2002;176:101-9 pubmed
    ..Recently, we have shown that IQGAP1, a target molecule of Cdc42 and Rac1 small GTPases, is involved in this localized release from the E-cadherin-..
  2. Mateer S, McDaniel A, Nicolas V, Habermacher G, Lin M, Cromer D, et al. The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. J Biol Chem. 2002;277:12324-33 pubmed
    b>IQGAP1 colocalizes with actin filaments in the cell cortex and binds in vitro to F-actin and several signaling proteins, including calmodulin, Cdc42, Rac1, and beta-catenin...
  3. Tekletsadik Y, Sonn R, Osman M. A conserved role of IQGAP1 in regulating TOR complex 1. J Cell Sci. 2012;125:2041-52 pubmed publisher
    ..b>IQGAP1, a widely conserved effector and/or regulator of the GTPase CDC42, is a putative oncoprotein that controls cell ..
  4. Swart Mataraza J, Li Z, Sacks D. IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J Biol Chem. 2002;277:24753-63 pubmed
    The Ras-GAP related protein IQGAP1 binds several proteins, including actin, calmodulin, E-cadherin and the Rho family GTPase Cdc42. To gain insight into its in vivo function, IQGAP1 was overexpressed in mammalian cells...
  5. Roy M, Li Z, Sacks D. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem. 2004;279:17329-37 pubmed
    b>IQGAP1 binds several proteins including actin, calmodulin, E-cadherin, beta-catenin, Cdc42, Rac1, and CLIP-170...
  6. Mataraza J, Briggs M, Li Z, Entwistle A, Ridley A, Sacks D. IQGAP1 promotes cell motility and invasion. J Biol Chem. 2003;278:41237-45 pubmed
    ..The scaffolding protein IQGAP1 binds to Cdc42, increasing the amount of active Cdc42 both in vitro and in cells...
  7. Brandt D, Marion S, Griffiths G, Watanabe T, Kaibuchi K, Grosse R. Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol. 2007;178:193-200 pubmed
    ..In this study, we identify the cytoskeletal scaffold protein IQGAP1 as a Dia1-binding protein that is necessary for its subcellular location...
  8. Liu C, Billadeau D, Abdelhakim H, Leof E, Kaibuchi K, Bernabeu C, et al. IQGAP1 suppresses T?RII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest. 2013;123:1138-56 pubmed publisher
    ..Here, we demonstrate that IQ motif containing GTPase activating protein 1 (IQGAP1) binds to TGF-? receptor II (T?RII) and suppresses T?RII-mediated signaling in pericytes to prevent ..
  9. Li Z, Sacks D. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem. 2003;278:4347-52 pubmed
    ..One of these IQ-containing proteins, IQGAP1, interacts with several targets, including Cdc42, beta-catenin, E-cadherin, and actin, in a calmodulin-regulated ..
  10. Fukata M, Kuroda S, Fujii K, Nakamura T, Shoji I, Matsuura Y, et al. Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42. J Biol Chem. 1997;272:29579-83 pubmed
    We have previously shown that IQGAP1, a recently identified target for Cdc42 and Rac1 small GTPases, showed a distribution similar to that of cortical actin cytoskeleton at the membrane ruffling area induced by insulin and Rac1(val12) (..
  11. Morita E, Sandrin V, Chung H, Morham S, Gygi S, Rodesch C, et al. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 2007;26:4215-27 pubmed
    ..ALIX and TSG101/ESCRT-I also bind a series of proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1, and IQGAP1. ALIX and TSG101 concentrate at centrosomes and are then recruited to the midbodies of dividing cells through ..
  12. Wang X, Li X, Zhai L, Liu Z, Chen X, Pei Y. Overexpression of IQGAP1 in human pancreatic cancer. Hepatobiliary Pancreat Dis Int. 2013;12:540-5 pubmed
    ..The scaffold protein IQGAP1 shows elevated levels in a variety of cancer types...
  13. Kim H, White C, Sacks D. IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton. FEBS Lett. 2011;585:723-9 pubmed publisher
    ..b>IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades...
  14. Phillips Mason P, Gates T, Major D, Sacks D, Brady Kalnay S. The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. J Biol Chem. 2006;281:4903-10 pubmed
    ..We identified IQGAP1, a known regulator of the Rho GTPases, Cdc42 and Rac1, as a novel PTPmu-interacting protein...
  15. Ren J, Li Z, Crimmins D, Sacks D. Self-association of IQGAP1: characterization and functional sequelae. J Biol Chem. 2005;280:34548-57 pubmed
    The scaffolding protein IQGAP1 participates in numerous cellular functions by binding to target proteins such as actin, calmodulin, E-cadherin, beta-catenin, Cdc42, Rac1, and CLIP-170...
  16. Kanwar N, Wilkins J. IQGAP1 involvement in MTOC and granule polarization in NK-cell cytotoxicity. Eur J Immunol. 2011;41:2763-73 pubmed publisher
    ..We previously identified IQGAP1 as a cytoskeletal component of the NK-like cell line YTS...
  17. Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, et al. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell. 2004;7:871-83 pubmed
    ..We have found that IQGAP1, an effector of Rac1 and Cdc42, interacts directly with APC...
  18. Wu Y, Chen Y, Sang J, Xu W. RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1. Mol Med Rep. 2011;4:697-703 pubmed publisher
    The scaffold protein IQGAP1 is closely related to certain Rho GTPases. Research has revealed that IQGAP1 acts as an effector of Cdc42 and Rac1 in the regulation of cell activity such as proliferation and migration...
  19. Neel N, Sai J, Ham A, Sobolik Delmaire T, Mernaugh R, Richmond A. IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse". PLoS ONE. 2011;6:e23813 pubmed publisher
    ..IQ motif containing GTPase activating protein 1 (IQGAP1) was among the novel proteins identified to interact directly with CXCR2...
  20. Rigothier C, Auguste P, Welsh G, Lepreux S, Deminiere C, Mathieson P, et al. IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro. PLoS ONE. 2012;7:e37695 pubmed publisher
    b>IQGAP1 is a scaffold protein that interacts with proteins of the cytoskeleton and the intercellular adhesion complex...
  21. Wu Y, Tao Y, Chen Y, Xu W. RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1. PLoS ONE. 2012;7:e48917 pubmed publisher
    ..research results showed that both Ras homolog family member C (RhoC) and IQ-domain GTPase-activating protein 1 (IQGAP1) were over-expressed in gastric cancer tissues and cells, but their role in tumorigenensis has not been addressed ..
  22. McNulty D, Li Z, White C, Sacks D, Annan R. MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem. 2011;286:15010-21 pubmed publisher
    ..Recent studies document IQGAP1 as a scaffold for the MAPK cascade, binding directly to B-Raf, MEK, and ERK and regulating their activation in ..
  23. Bourguignon L, Gilad E, Rothman K, Peyrollier K. Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. J Biol Chem. 2005;280:11961-72 pubmed
    In this study, we have examined the interaction of hyaluronan (HA)-CD44 with IQGAP1 (one of the binding partners for the Rho GTPase Cdc42) in SK-OV-3.ipl human ovarian tumor cells...
  24. Le Clainche C, Schlaepfer D, Ferrari A, Klingauf M, Grohmanova K, Veligodskiy A, et al. IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway. J Biol Chem. 2007;282:426-35 pubmed
    b>IQGAP1 is a conserved modular protein overexpressed in cancer and involved in organizing actin and microtubules in motile processes such as adhesion, migration, and cytokinesis...
  25. Chen F, Zhu H, Zhou L, Wu S, Wang J, Chen Z. IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation. Exp Mol Med. 2010;42:477-83 pubmed
    The scaffold protein IQGAP1 shows elevated levels in several cancer types, but its expression in hepatocellular carcinoma is unknown...
  26. Briggs M, Li Z, Sacks D. IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J Biol Chem. 2002;277:7453-65 pubmed
    ..The recently discovered calmodulin-binding protein IQGAP1 binds stoichiometrically to beta-catenin and regulates the association of beta-catenin with the cell-cell adhesion ..
  27. Choi S, Thapa N, Hedman A, Li Z, Sacks D, Anderson R. IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. EMBO J. 2013;32:2617-30 pubmed publisher
    ..we show that type I? phosphatidylinositol 4-phosphate 5-kinase (PIPKI?) interacts with the cytoskeleton regulator, IQGAP1, and modulates IQGAP1 function in migration...
  28. Li Q, Stuenkel E. Calcium negatively modulates calmodulin interaction with IQGAP1. Biochem Biophys Res Commun. 2004;317:787-95 pubmed
    b>IQGAP1 regulates cytoskeletal dynamics through interactions with the Rho family GTPases Rac1 and Cdc42, F-actin, and beta-catenin. Calmodulin interaction with IQ motifs of IQGAP1 negatively influences these IQGAP1 interactions...
  29. Nakhaei Nejad M, Zhang Q, Murray A. Endothelial IQGAP1 regulates efficient lymphocyte transendothelial migration. Eur J Immunol. 2010;40:204-13 pubmed publisher
    ..We studied the role of IQGAP1, an adaptor protein that binds to filamentous-actin and microtubules (MT) at interendothelial junctions, during ..
  30. Mataraza J, Li Z, Jeong H, Brown M, Sacks D. Multiple proteins mediate IQGAP1-stimulated cell migration. Cell Signal. 2007;19:1857-65 pubmed
    ..The scaffold protein IQGAP1, which binds multiple proteins and regulates their functions, promotes cell motility...
  31. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, et al. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell. 2002;109:873-85 pubmed
    ..CLIP-170 binds to the growing ends of microtubules and plays pivotal roles in orientation. We have found that IQGAP1, an effector of Rac1 and Cdc42, interacts with CLIP-170...
  32. Noritake J, Fukata M, Sato K, Nakagawa M, Watanabe T, Izumi N, et al. Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell. 2004;15:1065-76 pubmed
    ..However, the modes of activation and action of Rac1 remain to be clarified. We here found that suppression of IQGAP1, an actin-binding protein and an effector of Rac1, by small interfering RNA apparently reduced the accumulation of ..
  33. Buss C, Muller D, Rüter C, Heusipp G, Schmidt M. Identification and characterization of Ibe, a novel type III effector protein of A/E pathogens targeting human IQGAP1. Cell Microbiol. 2009;11:661-77 pubmed publisher
    ..Using affinity purification we identified IQGAP1, a scaffolding protein involved in the regulation of the actin cytoskeleton, as a putative host cell target...
  34. David S, Ghosh C, Mukherjee A, Parikh S. Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler Thromb Vasc Biol. 2011;31:2643-52 pubmed publisher
    IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and by binding the Rho GTPase Rac1 to maintain its activity...
  35. Grohmanova K, Schlaepfer D, Hess D, Gutierrez P, Beck M, Kroschewski R. Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. J Biol Chem. 2004;279:48495-504 pubmed
    ..The cell-cell contact regulator and actin-binding protein IQGAP1 is described as effector of Cdc42 and Rac...
  36. Meyer R, Sacks D, Rahimi N. IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS ONE. 2008;3:e3848 pubmed publisher
    ..c-Src also catalyzes tyrosine phosphorylation of IQGAP1 and acts as an adaptor to bridge IQGAP1 to VEGFR-2...
  37. Wang J, Sonn R, Tekletsadik Y, Samorodnitsky D, Osman M. IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway. J Cell Sci. 2009;122:2024-33 pubmed publisher
    ..b>IQGAP1, an effector of CDC42 GTPase has been implicated in the modulation of cell architecture, regulation of exocytosis ..
  38. Sharma M, Henderson B. IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. J Biol Chem. 2007;282:8545-56 pubmed
    ..Here we show that beta-catenin co-localizes with IQ-domain GTPase-activating protein 1 (IQGAP1), adenomatous polyposis coli (APC), and N-cadherin at actin-positive membrane ruffles in NIH 3T3 fibroblasts...
  39. Dong P, Nabeshima K, Nishimura N, Kawakami T, Hachisuga T, Kawarabayashi T, et al. Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas. Cancer Lett. 2006;243:120-7 pubmed
    b>IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and E-cadherin-mediated cell adhesion...
  40. Tirnauer J. A new cytoskeletal connection for APC: linked to actin through IQGAP. Dev Cell. 2004;7:778-80 pubmed
    ..In this issue of Developmental Cell, Watanabe et al. now show a molecular connection between the actin crosslinking protein IQGAP1 and the microtubule-stabilizing protein APC that impacts cells' ability to migrate into a wound.
  41. Hart M, Callow M, Souza B, Polakis P. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996;15:2997-3005 pubmed
    ..p195 was found to be identical to IQGAP1, a protein previously reported to bind ras...
  42. Brill S, Li S, Lyman C, Church D, Wasmuth J, Weissbach L, et al. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol. 1996;16:4869-78 pubmed
    We previously described IQGAP1 as a human protein related to a putative Ras GTPase-activating protein (RasGAP) from the fission yeast Schizosaccharomyces pombe...
  43. Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, Iwamatsu A, et al. Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem. 1996;271:23363-7 pubmed
    ..Moreover, IQGAP was accumulated at the cell-cell junction in MDCK cells, where alpha-catenin and ZO-1 were localized. These results suggest that IQGAP is a novel target molecule for Cdc42 and Rac1. ..
  44. Brown M, Bry L, Li Z, Sacks D. IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42. J Biol Chem. 2007;282:30265-72 pubmed
    ..b>IQGAP1 is a multidomain protein that influences numerous cellular functions, including modulation of Rac1/Cdc42 signaling ..
  45. Dong P, Jia N, Xu Z, Liu Y, Li D, Feng Y. Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro. J Exp Clin Cancer Res. 2008;27:77 pubmed publisher
    b>IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown...
  46. Jeong H, Li Z, Brown M, Sacks D. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem. 2007;282:20752-62 pubmed
    b>IQGAP1 is a scaffolding protein involved in multiple fundamental cellular activities, including transcription, cell-cell attachment, and regulation of the cytoskeleton...
  47. Weissbach L, Settleman J, Kalady M, Snijders A, Murthy A, Yan Y, et al. Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J Biol Chem. 1994;269:20517-21 pubmed
    ..We report here the identification of a new human cDNA clone, IQGAP1, which predicts a 1657-amino acid protein that displays extensive sequence similarity to the catalytic domain of ..
  48. Joyal J, Annan R, Ho Y, Huddleston M, Carr S, Hart M, et al. Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry. J Biol Chem. 1997;272:15419-25 pubmed
    ..This 190-kDa protein was identified as IQGAP1 by nanoelectrospray mass spectrometry and collision-induced dissociation tandem mass spectrometry...
  49. Jadeski L, Mataraza J, Jeong H, Li Z, Sacks D. IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J Biol Chem. 2008;283:1008-17 pubmed
    The scaffold protein IQGAP1 integrates signaling pathways and participates in diverse cellular activities...
  50. Yamaoka Tojo M, Ushio Fukai M, Hilenski L, Dikalov S, Chen Y, Tojo T, et al. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Circ Res. 2004;95:276-83 pubmed
    ..Little is known about the underlying molecular mechanisms. IQGAP1 is a scaffolding protein that controls cellular motility and morphogenesis by interacting directly with ..
  51. White C, Erdemir H, Sacks D. IQGAP1 and its binding proteins control diverse biological functions. Cell Signal. 2012;24:826-34 pubmed publisher
    ..The most extensively studied family member is the ubiquitously expressed scaffold protein IQGAP1, which participates in multiple essential aspects of mammalian biology...
  52. Mataraza J, Briggs M, Li Z, Frank R, Sacks D. Identification and characterization of the Cdc42-binding site of IQGAP1. Biochem Biophys Res Commun. 2003;305:315-21 pubmed
    b>IQGAP1 is a multi-domained protein that integrates signaling of the Rho family GTPase Cdc42 with regulation of the cytoskeleton...
  53. Yin N, Shi J, Wang D, Tong T, Wang M, Fan F, et al. IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer. Biochem Biophys Res Commun. 2012;421:64-9 pubmed publisher
    b>IQGAP1, a ubiquitously expressed scaffold protein, has been identified in a wide range of organisms. It participates in multiple aspects of cellular events by binding to and regulating numerous interacting proteins...
  54. Bashour A, Fullerton A, Hart M, Bloom G. IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments. J Cell Biol. 1997;137:1555-66 pubmed
    ..We now report the purification and characterization of a protein, IQGAP1, which is likely to mediate effects of these GTPases on microfilaments...
  55. Hayashi H, Nabeshima K, Aoki M, Hamasaki M, Enatsu S, Yamauchi Y, et al. Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion. Int J Cancer. 2010;126:2563-74 pubmed publisher
    b>IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and E-cadherin-mediated cell adhesion...
  56. Liu X, Kilpeläinen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, et al. Characterization of the interactions of the nephrin intracellular domain. FEBS J. 2005;272:228-43 pubmed
    ..Peptide mass fingerprinting and amino acid sequencing identified this protein as IQGAP1, an effector protein of small GTPases Rac1 and Cdc42 and a putative regulator of cell-cell adherens junctions...
  57. Zheng H, Song F, Zhang L, Yang D, Ji P, Wang Y, et al. Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer. Int J Oncol. 2011;38:1153-61 pubmed publisher
    b>IQGAP1 knockout mice develop gastric cancer, but the IQGAP1 protein is associated with some advanced-stage human cancers...
  58. Johnson M, Sharma M, Brocardo M, Henderson B. IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int J Biochem Cell Biol. 2011;43:65-73 pubmed publisher
    b>IQGAP1 is a plasma membrane-associated protein and an important regulator of the actin cytoskeleton, contributing to cell migration, polarity and adhesion...