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Genomes and Genes | IPO7SummaryGene Symbol: IPO7 Description: importin 7 Alias: Imp7, RANBP7, RAN-binding protein 7, importin-7 Species: human Top Publications
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Publications
A novel class of RanGTP binding proteinsD Gorlich
Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
J Cell Biol 138:65-80. 1997..We have confirmed specific RanGTP binding for some of them, namely for two novel factors, RanBP7 and RanBP8, for CAS, Pse1p, and Msn5p, and for the cell cycle regulator Cse1p from Saccharomyces cerevisiae...
Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1Marc Arnold
Universitat Heidelberg, Abteilung Virologie, Germany
J Biol Chem 281:20883-90. 2006..Besides importin beta, the transport receptors transportin, importin 5, and importin 7 specifically interact with Rev and promote its nuclear import in digitonin-permeabilized cells...- Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanismsEiko Saijou
Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
J Biol Chem 282:32327-37. 2007..Taken together, these results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export... - tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexesLyubov Zaitseva
1Wohl Virion Centre, London, United Kingdom
PLoS Biol 4:e332. 2006..Here we provide evidence that at least some tRNA species can be imported into the nucleus of human cells and promote HIV-1 nuclear import... - Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7Ariberto Fassati
The Wohl Virion Centre, Windeyer Institute, University College London Medical School, 46 Cleveland Street, London W1T 4JF, UK
EMBO J 22:3675-85. 2003..We have studied nuclear import of purified HIV-1 RTCs in primary macrophages and found that importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the process... - Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cellsS Jäkel
Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
EMBO J 17:4491-502. 1998..at least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins... - The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1S Jäkel
Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
EMBO J 18:2411-23. 1999..investigated nuclear import of the linker histone H1 and found that two receptors, importin beta (Impbeta) and importin 7 (Imp7, RanBP7), play a critical role in this process... - Sequence analysis of two cosmids from Schizosaccharomyces pombe chromosome IIIM Lucas
Institut National Agronomique, Laboratoire de Genetique Moleculaire et Cellulaire, INRA, CNRS, Centre de Biotechnologies Agro Industrielles, 78850 Thiverval Grignon, France
Yeast 16:1519-26. 2000..for RNA 3' ss-tail, an UTP-glucose-1-phosphate uridylyltransferase, a leukotriene A(4) hydrolase, a member of the RanBP7-importin beta-Cse1p superfamily, a Ca(++)-calmodulin-dependent serine/threonine protein kinase and a prohibitin .. - Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signalYuji Isegawa
Department of Infectious Disease Control, G 5, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
J Virol 82:710-8. 2008..These results suggest a relationship between the localization of NPI2/importin-alpha7 and the cell tropism of HHV-6... - Preferential utilization of Imp7/8 in nuclear import of SmadsXiaohao Yao
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 283:22867-74. 2008..We demonstrate that both TGF-beta-induced and basal state spontaneous nuclear import of Smad4 require importin 7 and 8 (Imp7,8)... - HIV-1 exploits importin 7 to maximize nuclear import of its DNA genomeLyubov Zaitseva
Wohl Virion Centre, Division of Infection and Immunity, University College London, London, UK
Retrovirology 6:11. 2009..import of the HIV-1 reverse transcription complex (RTC) is critical for infection of non dividing cells, and importin 7 (imp7) has been implicated in this process... - ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteinsShaoyi Huang
Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Biosci Rep 30:159-68. 2010..Thus ARHI-induced disruption of importin-binding to cargo proteins, including STAT3, could serve as an important regulatory mechanism that contributes to the tumour-suppressor function of ARHI... - A genome-wide association study of hypertension and blood pressure in African AmericansAdebowale Adeyemo
Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
PLoS Genet 5:e1000564. 2009..multiple SNPs reaching genome-wide significance for systolic BP in or near the genes: PMS1, SLC24A4, YWHA7, IPO7, and CACANA1H... 
Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7Georgia Chachami
Laboratory of Biochemistry, School of Medicine, University of Thessaly, Mezourlo, 41110 Larissa, Greece
Biochem Biophys Res Commun 390:235-40. 2009..Moreover, the interaction of importin 7 with HIF-1alpha is mapped at its N-terminal part encompassing the bHLH-PAS(A) domain...- Identification of novel genes that mediate innate immunity using inbred miceIvana V Yang
Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
Genetics 183:1535-44. 2009..genes that have not previously been implicated in innate immunity, namely, 1110058L19Rik, 4933415F23Rik, Fbxo9, and Ipo7. These genes could represent potential sepsis biomarkers or therapeutic targets that should be further investigated .. - Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assayLars Dölken
Max von Pettenkofer Institute, Ludwig Maximilians University Munich, 80336 Munich, Germany
Cell Host Microbe 7:324-34. 2010..Two genes governing cellular transport processes (TOMM22 and IPO7) were confirmed to be targeted by EBV miRNAs... - Functional comparison of H1 histones in Xenopus reveals isoform-specific regulation by Cdk1 and RanGTPBenjamin S Freedman
Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, CA 94720 3200, USA
Curr Biol 20:1048-52. 2010..Nuclear import receptors RanBP7 and importin beta bind tightly to somatic H1 but not H1M, and addition of a constitutively active Ran mutant .. - Specific nucleoporin requirement for Smad nuclear translocationXiaochu Chen
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 30:4022-34. 2010..Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but not the .. - Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extractsF J Nicolas
Zeneca Laboratory of Molecular and Cellular Biology, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
J Cell Sci 110:3019-30. 1997..egg extracts with Ran, importin-beta/karyopherin-beta and importin-alpha/karyopherin-alpha, but not p10, p120/RanBP7, RanBP2 or other nucleoporins... - Msk is required for nuclear import of TGF-{beta}/BMP-activated SmadsLan Xu
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Cell Biol 178:981-94. 2007..Moreover, knockdown of importin 7 and 8 (Imp7 and 8), the mammalian orthologues of Msk, markedly impaired nuclear accumulation of Smad1 in .. - Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replicationZhujun Ao
Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3
J Biol Chem 282:13456-67. 2007..Our results indicate that IN interacts specifically with host importin 7 (Imp7) in vivo, but does not interact with importin 8 (Imp8) or importin alpha (Rch1)... - Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)A Cichutek
Department of Pediatrics, University of Mainz, Mainz, Germany
Cytogenet Cell Genet 93:277-83. 2001..established, proving the conserved order of the genes and markers in both species: "cen-WEE1-D11S2043-ZNF143-RANBP7-CEGF1- ST5-D11S932-LMO1-D11S572-TUB-tel", with inverted order of the murine genes with respect to the .. - Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportinK A Dean
Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Sci 114:3479-85. 2001..Our results show that at least one mammalian SRP protein is specifically imported into the nucleus, by members of the importin beta family of transport receptors, and the findings add additional evidence for nuclear assembly of SRP... - Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domainsStefan Jäkel
ZMBH, INF 282, D 69120 Heidelberg, Germany
EMBO J 21:377-86. 2002..The same applies to Imp4, Imp5, Imp7 and Impbeta and their respective basic import substrates... - The requirement of H1 histones for a heterodimeric nuclear import receptorMarc Bauerle
Institut fur Biochemie und Molekulare Zellbiologie, Abteilung für Molekularbiologie, Universitat Gottingen, D 37073 Gottingen, Germany
J Biol Chem 277:32480-9. 2002..are imported into the nucleus through an energy-dependent process that can be mediated by an importin beta-importin 7 (Impbeta-Imp7) heterodimer... - Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression libraryL Y Luo
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
Br J Cancer 87:339-43. 2002..protein S18, heat shock protein 90, JK-recombination signal binding protein, ribonucleoprotein H1, RAN binding protein 7, TG-interacting factor, eukaryotic translation initiation factor p40 subunit, human amyloid precursor .. - Inhibition of nuclear import by the proapoptotic protein CC3Frank W King
Cancer Research Institute, University of California San Francisco, 94115, USA
Mol Cell Biol 24:7091-101. 2004..Significantly, a dominant-negative form of importin beta1 shown previously to inhibit multiple transport pathways induces rapid cell death, strongly indicating that inhibition of nuclear transport serves as a potent apoptotic signal... - Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13Joerg Kahle
Institut fur Biochemie und Molekulare Zellbiologie, Abteilung Molekularbiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
Mol Cell Biol 25:5339-54. 2005..Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions... - NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubulesKatharina Ribbeck
European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
Mol Biol Cell 17:2646-60. 2006..components we show that the activity of NuSAP is differentially regulated by Importin (Imp) alpha, Impbeta, and Imp7. While Impalpha and Imp7 appear to block the microtubule-stabilizing activity of NuSAP, Impbeta specifically .. - CRM1-mediated recycling of snurportin 1 to the cytoplasmE Paraskeva
Zentrum fur Molekulare Biologie der Universitat Heidelberg, D 69120 Heidelberg, Germany
J Cell Biol 145:255-64. 1999..This mechanism appears crucial for productive import cycles as it can ensure that CRM1 only exports snurportin 1 that has already released its import substrate in the nucleus... - A role for NuSAP in linking microtubules to mitotic chromosomesKatharina Ribbeck
European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Curr Biol 17:230-6. 2007..NuSAP-chromatin interaction is subject to Ran regulation and can be suppressed by Importin alpha (Impalpha) and Imp7. We propose that the presence of MT binding agents such as NuSAP, which can be directly immobilized on chromatin, .. - Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serineJinbiao Chen
Centre for Vascular Research, University of New South Wales, Sydney, NSW, Australia
Int J Biochem Cell Biol 43:905-12. 2011....
Research Grants
- Receptor Tyrosine Kinase Regulation of Nuclear ImportLizabeth Perkins; Fiscal Year: 2004..In a screen for Csw binding proteins, D-Importin 7/RanBP7 (Dim-7), a member of the Importin B superfamily of nuclear import proteins, was identified...
- Nucleocytoplasmic Trafficking of SmadsLan Xu; Fiscal Year: 2007..These regulators of subcellular localization potential targets for therapeutic interventions aimed at modulating TGF-beta signaling diseases such as cancer. ..
- Nucleocytoplasmic Trafficking of SmadsLan Xu; Fiscal Year: 2007..These regulators of subcellular localization of Smad may serve as potential targets for therapeutic interventions aimed at modulating TGF-beta signaling in treatment of diseases such as cancer. ..