Gene Symbol: IPO7
Description: importin 7
Alias: Imp7, RANBP7, importin-7, RAN-binding protein 7
Species: human
Products:     IPO7

Top Publications

  1. Jäkel S, Gorlich D. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 1998;17:4491-502 pubmed
    ..at least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins...
  2. Gorlich D, Dabrowski M, Bischoff F, Kutay U, Bork P, Hartmann E, et al. A novel class of RanGTP binding proteins. J Cell Biol. 1997;138:65-80 pubmed
    ..We have confirmed specific RanGTP binding for some of them, namely for two novel factors, RanBP7 and RanBP8, for CAS, Pse1p, and Msn5p, and for the cell cycle regulator Cse1p from Saccharomyces cerevisiae...
  3. Jäkel S, Albig W, Kutay U, Bischoff F, Schwamborn K, Doenecke D, et al. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J. 1999;18:2411-23 pubmed
    ..investigated nuclear import of the linker histone H1 and found that two receptors, importin beta (Impbeta) and importin 7 (Imp7, RanBP7), play a critical role in this process...
  4. Saijou E, Itoh T, Kim K, Iemura S, Natsume T, Miyajima A. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. J Biol Chem. 2007;282:32327-37 pubmed
  5. Ao Z, Huang G, Yao H, Xu Z, Labine M, Cochrane A, et al. Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication. J Biol Chem. 2007;282:13456-67 pubmed
    ..Our results indicate that IN interacts specifically with host importin 7 (Imp7) in vivo, but does not interact with importin 8 (Imp8) or importin alpha (Rch1)...
  6. Fassati A, Gorlich D, Harrison I, Zaytseva L, Mingot J. Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7. EMBO J. 2003;22:3675-85 pubmed
    ..We have studied nuclear import of purified HIV-1 RTCs in primary macrophages and found that importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the process...
  7. Arnold M, Nath A, Hauber J, Kehlenbach R. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. J Biol Chem. 2006;281:20883-90 pubmed
    ..Besides importin beta, the transport receptors transportin, importin 5, and importin 7 specifically interact with Rev and promote its nuclear import in digitonin-permeabilized cells...
  8. Zaitseva L, Cherepanov P, Leyens L, Wilson S, Rasaiyaah J, Fassati A. HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology. 2009;6:11 pubmed publisher
    ..import of the HIV-1 reverse transcription complex (RTC) is critical for infection of non dividing cells, and importin 7 (imp7) has been implicated in this process...
  9. Zaitseva L, Myers R, Fassati A. tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes. PLoS Biol. 2006;4:e332 pubmed
    ..Here we provide evidence that at least some tRNA species can be imported into the nucleus of human cells and promote HIV-1 nuclear import. ..

More Information


  1. Zehorai E, Seger R. Beta-Like Importins Mediate the Nuclear Translocation of MAPKs. Cell Physiol Biochem. 2019;52:802-821 pubmed publisher
    ..We further demonstrate that the translocation requires the stimulated formation of heterotrimers composed of Imp3/Imp7/MAPK or Imp3/Imp9/MAPK...
  2. Ivic N, Potočnjak M, Solis Mezarino V, Herzog F, Bilokapic S, Halic M. Fuzzy Interactions Form and Shape the Histone Transport Complex. Mol Cell. 2019;: pubmed publisher
    ..In this study, we determined the cryo-EM structure of the Imp7:Impβ:H1.0 complex, showing that the two importins form a cradle that accommodates the linker histone. The H1...
  3. Barbagallo C, Brex D, Caponnetto A, Cirnigliaro M, Scalia M, Magnano A, et al. LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions. Mol Ther Nucleic Acids. 2018;12:229-241 pubmed publisher
    ..controlled by MAPKs through CEBPB; (2) sequester miR-135a, miR-143, miR-214, and miR-1271, protecting ANLN, BIRC5, IPO7, KIF2A, and KIF23 from microRNA (miRNA)-induced degradation; and (3) interact with mRNA 3'-UTRs, preventing miRNA ..
  4. Boye A, Wu C, Jiang Y, Wang J, Wu J, Yang X, et al. Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism. J Ethnopharmacol. 2015;169:219-28 pubmed publisher
    ..Also phosphorylation and subcellular distribution of pSmad2/3, Smad4 and Imp7/8 in TGF-β1-stimulated HSC and HepG2 cells were monitored...
  5. Kim B, Kwon H, Sohn E, Hwang S, Kwon O, Kim S. Activation of caspases and inhibition of ribosome biogenesis mediate antitumor activity of Chijongdan in A549 non-small lung cancer cells. BMC Complement Altern Med. 2014;14:420 pubmed publisher
    ..ribosomal biogenesis related proteins such as upstream binding factor (UBF), Fibrillarin, NPM (B23) and Importin-7 (IPO7) and conversely pan-caspase inhibitor Z--VAD-FMK reversed the apoptotic ability of Chijongdan to cleave PARP and ..
  6. Monteleone F, Taverna S, Alessandro R, Fontana S. SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis. J Exp Clin Cancer Res. 2018;37:170 pubmed publisher
    ..of Hypoxia inducible factor 1 α (HIF-1α) was assayed by evaluating its activation status and the modulation of importin 7 (IPO7) and miR-22 was assessed by quantitative PCR and western blot analysis...
  7. Wilkes M, Repellin C, Kang J, Andrianifahanana M, Yin X, Leof E. Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling. Mol Biol Cell. 2015;26:3879-91 pubmed publisher
    ..Although SNX9 does not bind nucleoporins Nup153 or Nup214 or some β importins (Imp7 or Impβ), it mediates the association of pSmad3 with Imp8 and the nuclear membrane...
  8. Jiang Y, Wu C, Boye A, Wu J, Wang J, Yang X, et al. MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear translocation in myofibroblasts via Imp7/8 mediation. Mol Cell Biochem. 2015;406:255-62 pubmed publisher
    ..protein expression and nuclear translocation of phosphorylated (p)-Smad2C/L, oncogenic pSmad3L, Smad4, importin7/8 (Imp7/8), and plasminogen activator inhibitor (PAI)-1 (Protein and mRNA), while decreased Smad7 protein expression...
  9. Pérez Ramírez M, Hernández Jiménez A, Guerrero Guerrero A, Benadón Darszon E, Pérezpeña Díazconti M, Siordia Reyes A, et al. Genomics and epigenetics: A study of ependymomas in pediatric patients. Clin Neurol Neurosurg. 2016;144:53-8 pubmed publisher
    ..We found 481 genes with altered expression. The genes IMMT, JHDMD1D, ASAH1, ZWINT, IPO7, GNAO1 and CISD3 were found to be altered among the three levels. The 2p22.3, 8p11.23-p11.22 and 14q32...
  10. Coombes J, Schevzov G, Kan C, Petti C, Maritz M, Whittaker S, et al. Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout. Cell Mol Biol Lett. 2015;20:626-46 pubmed publisher
    ..Finally, we show that pERK and Importin 7 protein interactions are significantly decreased in the SV40 large T antigen immortalized KO MEFs but not in the ..
  11. Chachami G, Paraskeva E, Mingot J, Braliou G, Gorlich D, Simos G. Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7. Biochem Biophys Res Commun. 2009;390:235-40 pubmed publisher
    ..Moreover, the interaction of importin 7 with HIF-1alpha is mapped at its N-terminal part encompassing the bHLH-PAS(A) domain...
  12. Soniat M, Cagatay T, Chook Y. Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins. J Biol Chem. 2016;291:21171-21183 pubmed
    ..Biochemical studies of H3 and H4 tails binding to seven Importins, Imp?, Kap?2, Imp4, Imp5, Imp7, Imp9, and Imp?, show the H3 tail binding more tightly than the H4 tail...
  13. Sciuto M, Warnken U, Schnolzer M, Valvo C, Brunetto L, Boe A, et al. Two-Step Coimmunoprecipitation (TIP) Enables Efficient and Highly Selective Isolation of Native Protein Complexes. Mol Cell Proteomics. 2018;17:993-1009 pubmed publisher
    ..T cells, which recapitulated all major known interactors, but also enabled the proteomics discovery of PPM1G and IPO7 as new interaction partners...
  14. Golomb L, Bublik D, Wilder S, Nevo R, Kiss V, Grabusic K, et al. Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell. 2012;45:222-32 pubmed publisher
    ..We report that transcription of the ?-karyopherin genes importin 7 (IPO7) and exportin 1 (XPO1), and several additional nuclear import receptors, is regulated positively by c-Myc ..
  15. Xue J, Zhou A, Tan C, Wu Y, Lee H, Li W, et al. Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression. J Biol Chem. 2015;290:18662-70 pubmed publisher
    ..We observed that FOXM1 directly binds to the importin-7 (IPO7) promoter and increases its promoter activity...
  16. Chen J, Liu M, Parish C, Chong B, Khachigian L. Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine. Int J Biochem Cell Biol. 2011;43:905-12 pubmed publisher
  17. Adeyemo A, Gerry N, Chen G, Herbert A, Doumatey A, Huang H, et al. A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet. 2009;5:e1000564 pubmed publisher
    ..multiple SNPs reaching genome-wide significance for systolic BP in or near the genes: PMS1, SLC24A4, YWHA7, IPO7, and CACANA1H...
  18. Lipowsky G, Bischoff F, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, et al. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J. 2000;19:4362-71 pubmed
    ..The export signal in eIF-5A appears to be complex and to involve the hypusine modification that is unique to eIF-5A. We discuss possible cellular roles for nuclear export of eIF-5A. ..
  19. Kutay U, Hartmann E, Treichel N, Calado A, Carmo Fonseca M, Prehn S, et al. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem. 2000;275:40163-8 pubmed
    ..Like the other members of the transport receptor superfamily, RanBP16 interacts with the nuclear pore complex and is able to enter the nucleus independent of energy and additional nuclear transport receptors. ..
  20. Hou Z, Li Q, He L, Lim H, Fu X, Cheung N, et al. Microtubule association of the neuronal p35 activator of Cdk5. J Biol Chem. 2007;282:18666-70 pubmed
    ..Together, these findings suggest that p35 is a microtubule-associated protein that modulates microtubule dynamics. Also, microtubules play an important role in the control of Cdk5 activation. ..
  21. Mohammad D, Nore B, Gustafsson M, Mohamed A, Smith C. Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7. Int J Biochem Cell Biol. 2016;78:63-74 pubmed publisher
    ..In addition, 14-3-3 was required for the regulation SYK's interaction with BLNK and attenuated SYK binding to Importin 7 (5-fold), thereby perturbing shuttling to the nucleus...
  22. Jayappa K, Ao Z, Yao X. The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. Int J Biochem Mol Biol. 2012;3:70-85 pubmed
    ..Hereby we aim to further our understanding on molecular mechanism of HIV-1 nuclear import and its potential usefulness for anti-HIV-1 strategies. ..
  23. Braun D, Sadowski C, Kohl S, Lovric S, Astrinidis S, Pabst W, et al. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nat Genet. 2016;48:457-65 pubmed publisher
    ..We hereby demonstrate that mutations of NUP genes cause a distinct renal disease and identify aberrant SMAD signaling as a new disease mechanism of SRNS, opening a potential new avenue for treatment. ..
  24. Jacob A, Singh R, Mohammad F, Bebee T, Chandler D. The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. J Biol Chem. 2014;289:17350-64 pubmed publisher
    ..These findings are the first report describing the regulation of alternative splicing of MDM2 mediated by the oncogenic factor FUBP1. ..
  25. Boutimah F, Eekels J, Liu Y, Berkhout B. Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors. Antiviral Res. 2013;98:121-9 pubmed publisher
    ..These results support the idea to validate the therapeutic potential of this anti-HIV approach in appropriate in vivo models...
  26. Kang H, Lee Y, Shin J, Andrabi S, Chi Z, Gagné J, et al. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci U S A. 2011;108:14103-8 pubmed publisher
    ..These results define Iduna as a PAR-dependent E3 ligase that regulates cell survival and DNA repair. ..
  27. Yao X, Chen X, Cottonham C, Xu L. Preferential utilization of Imp7/8 in nuclear import of Smads. J Biol Chem. 2008;283:22867-74 pubmed publisher
    ..We demonstrate that both TGF-beta-induced and basal state spontaneous nuclear import of Smad4 require importin 7 and 8 (Imp7,8)...
  28. Isegawa Y, Miyamoto Y, Yasuda Y, Semi K, Tsujimura K, Fukunaga R, et al. Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal. J Virol. 2008;82:710-8 pubmed publisher
    ..These results suggest a relationship between the localization of NPI2/importin-alpha7 and the cell tropism of HHV-6...
  29. Kahle J, Baake M, Doenecke D, Albig W. Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol. 2005;25:5339-54 pubmed
    ..Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions. ..
  30. Bauerle M, Doenecke D, Albig W. The requirement of H1 histones for a heterodimeric nuclear import receptor. J Biol Chem. 2002;277:32480-9 pubmed
    ..are imported into the nucleus through an energy-dependent process that can be mediated by an importin beta-importin 7 (Impbeta-Imp7) heterodimer...
  31. King F, Shtivelman E. Inhibition of nuclear import by the proapoptotic protein CC3. Mol Cell Biol. 2004;24:7091-101 pubmed
    ..Significantly, a dominant-negative form of importin beta1 shown previously to inhibit multiple transport pathways induces rapid cell death, strongly indicating that inhibition of nuclear transport serves as a potent apoptotic signal. ..
  32. Paraskeva E, Izaurralde E, Bischoff F, Huber J, Kutay U, Hartmann E, et al. CRM1-mediated recycling of snurportin 1 to the cytoplasm. J Cell Biol. 1999;145:255-64 pubmed
    ..This mechanism appears crucial for productive import cycles as it can ensure that CRM1 only exports snurportin 1 that has already released its import substrate in the nucleus. ..
  33. Frohnert C, Hutten S, Wälde S, Nath A, Kehlenbach R. Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase. PLoS ONE. 2014;9:e88887 pubmed publisher
    ..Using an siRNA approach to deplete several import receptors, we identify importin 7 as a soluble nuclear transport factor that is required for efficient import...
  34. Ni L, Llewellyn R, Kesler C, Kelley J, Spencer A, Snow C, et al. Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor. Mol Cell Biol. 2013;33:4766-78 pubmed publisher
    ..The bipartite NLS is recognized by importin 7, a nuclear import receptor for several proteins...
  35. Dhanoya A, Wang T, Keshavarz Moore E, Fassati A, Chain B. Importin-7 mediates nuclear trafficking of DNA in mammalian cells. Traffic. 2013;14:165-75 pubmed publisher
    ..Here we show that the nuclear transport receptor importin 7 (imp7) supports nuclear import of supercoiled plasmid DNA and human mitochondrial DNA in a Ran and energy-..
  36. Levin A, Loyter A, Bukrinsky M. Strategies to inhibit viral protein nuclear import: HIV-1 as a target. Biochim Biophys Acta. 2011;1813:1646-53 pubmed publisher
    ..This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import. ..
  37. Huang S, Chang I, Lin W, Ye W, Luo R, Lu Z, et al. ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins. Biosci Rep. 2009;30:159-68 pubmed publisher
    ..Thus ARHI-induced disruption of importin-binding to cargo proteins, including STAT3, could serve as an important regulatory mechanism that contributes to the tumour-suppressor function of ARHI. ..
  38. Dean K, von Ahsen O, Gorlich D, Fried H. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. J Cell Sci. 2001;114:3479-85 pubmed
    ..Our results show that at least one mammalian SRP protein is specifically imported into the nucleus, by members of the importin beta family of transport receptors, and the findings add additional evidence for nuclear assembly of SRP. ..