IPO7

Summary

Gene Symbol: IPO7
Description: importin 7
Alias: Imp7, RANBP7, RAN-binding protein 7, importin-7
Species: human

Top Publications

  1. pmc Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis
    Lior Golomb
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 45:222-32. 2012
  2. pmc The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration
    Kallesh Danappa Jayappa
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba Winnipeg, MB, Canada
    Int J Biochem Mol Biol 3:70-85. 2012
  3. pmc Strategies to inhibit viral protein nuclear import: HIV-1 as a target
    Aviad Levin
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Biochim Biophys Acta 1813:1646-53. 2011
  4. pmc Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7
    Ariberto Fassati
    The Wohl Virion Centre, Windeyer Institute, University College London Medical School, 46 Cleveland Street, London W1T 4JF, UK
    EMBO J 22:3675-85. 2003
  5. ncbi Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication
    Zhujun Ao
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3
    J Biol Chem 282:13456-67. 2007
  6. ncbi Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1
    Marc Arnold
    Universitat Heidelberg, Abteilung Virologie, Germany
    J Biol Chem 281:20883-90. 2006
  7. pmc A novel class of RanGTP binding proteins
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 138:65-80. 1997
  8. pmc CRM1-mediated recycling of snurportin 1 to the cytoplasm
    E Paraskeva
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, D 69120 Heidelberg, Germany
    J Cell Biol 145:255-64. 1999
  9. pmc tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes
    Lyubov Zaitseva
    1Wohl Virion Centre, London, United Kingdom
    PLoS Biol 4:e332. 2006
  10. pmc Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 17:4491-502. 1998

Research Grants

Scientific Experts

  • Lan Xu
  • U Kutay
  • Lene Kleppe
  • Ariberto Fassati
  • Katharina Ribbeck
  • Y Isegawa
  • A Adeyemo
  • Ivana V Yang
  • D Gorlich
  • Lizabeth Perkins
  • Benjamin S Freedman
  • Lyubov Zaitseva
  • Xiaochu Chen
  • Zhujun Ao
  • Eldar Zehorai
  • Ji Hoon Jung
  • Hye Sook Kang
  • Arjun Dhanoya
  • Jaroslaw Szczyrba
  • Lior Golomb
  • Nikta Pashai
  • Kallesh Danappa Jayappa
  • Elisabeth Kremmer
  • Ho Chul Kang
  • Jinbiao Chen
  • Aviad Levin
  • Lars Dölken
  • Rebecca Heald
  • Shaoyi Huang
  • Xiaojian Yao
  • Georgia Chachami
  • Xiaohao Yao
  • S Jäkel
  • Eiko Saijou
  • Marc Arnold
  • José Manuel Mingot
  • Joerg Kahle
  • Steven P Zielske
  • Frank W King
  • F R Bischoff
  • Werner Albig
  • Detlef Doenecke
  • Rony Seger
  • Marc Bauerle
  • L Y Luo
  • Stefan Jäkel
  • Benjamin M Chain
  • Yong Koo Park
  • Wolf Wieland
  • Sven Wach
  • Eun Jung Sohn
  • Bonglee Kim
  • Eun Ah Shin
  • Sung Hoon Kim
  • Deok Beom Jung
  • Elke Nolte
  • Jiyeon Ock
  • Bastian Keck
  • Tse Wang
  • Heon Jin Lee
  • Hyo Jeong Lee
  • Miyong Yun
  • Celina Döll
  • Martin Hart
  • Robert Stöhr
  • Byoung Mog Kwon
  • Friedrich A Grässer
  • Eli Keshavarz-Moore
  • Duckgue Lee
  • Su Hyung Hong
  • Arndt Hartmann
  • Ji Hyun Kim
  • Yu Jin Lee
  • Helge Taubert
  • Bernd Wullich
  • Alejandro De Los Angeles
  • Siddharth Gupta
  • K A Dean
  • Kristina Grabusic
  • Vladimir Kiss
  • Débora Rosa Bublik
  • Raghothama Chaerkady
  • Reinat Nevo
  • Moshe Oren
  • Candace L Kerr
  • A Cichutek
  • Sylvia Wilder
  • John D Gearhart
  • Haiping Hao
  • Angelo All

Detail Information

Publications47

  1. pmc Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis
    Lior Golomb
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 45:222-32. 2012
    ..We report that transcription of the β-karyopherin genes importin 7 (IPO7) and exportin 1 (XPO1), and several additional nuclear import receptors, is regulated positively by c-Myc ..
  2. pmc The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration
    Kallesh Danappa Jayappa
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba Winnipeg, MB, Canada
    Int J Biochem Mol Biol 3:70-85. 2012
    ..Hereby we aim to further our understanding on molecular mechanism of HIV-1 nuclear import and its potential usefulness for anti-HIV-1 strategies...
  3. pmc Strategies to inhibit viral protein nuclear import: HIV-1 as a target
    Aviad Levin
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Biochim Biophys Acta 1813:1646-53. 2011
    ..This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import...
  4. pmc Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7
    Ariberto Fassati
    The Wohl Virion Centre, Windeyer Institute, University College London Medical School, 46 Cleveland Street, London W1T 4JF, UK
    EMBO J 22:3675-85. 2003
    ..We have studied nuclear import of purified HIV-1 RTCs in primary macrophages and found that importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the process...
  5. ncbi Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication
    Zhujun Ao
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3
    J Biol Chem 282:13456-67. 2007
    ..Our results indicate that IN interacts specifically with host importin 7 (Imp7) in vivo, but does not interact with importin 8 (Imp8) or importin alpha (Rch1)...
  6. ncbi Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1
    Marc Arnold
    Universitat Heidelberg, Abteilung Virologie, Germany
    J Biol Chem 281:20883-90. 2006
    ..Besides importin beta, the transport receptors transportin, importin 5, and importin 7 specifically interact with Rev and promote its nuclear import in digitonin-permeabilized cells...
  7. pmc A novel class of RanGTP binding proteins
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 138:65-80. 1997
    ..We have confirmed specific RanGTP binding for some of them, namely for two novel factors, RanBP7 and RanBP8, for CAS, Pse1p, and Msn5p, and for the cell cycle regulator Cse1p from Saccharomyces cerevisiae...
  8. pmc CRM1-mediated recycling of snurportin 1 to the cytoplasm
    E Paraskeva
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, D 69120 Heidelberg, Germany
    J Cell Biol 145:255-64. 1999
    ..This mechanism appears crucial for productive import cycles as it can ensure that CRM1 only exports snurportin 1 that has already released its import substrate in the nucleus...
  9. pmc tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes
    Lyubov Zaitseva
    1Wohl Virion Centre, London, United Kingdom
    PLoS Biol 4:e332. 2006
    ..Here we provide evidence that at least some tRNA species can be imported into the nucleus of human cells and promote HIV-1 nuclear import...
  10. pmc Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 17:4491-502. 1998
    ..at least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins...
  11. pmc The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    EMBO J 18:2411-23. 1999
    ..investigated nuclear import of the linker histone H1 and found that two receptors, importin beta (Impbeta) and importin 7 (Imp7, RanBP7), play a critical role in this process...
  12. pmc HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome
    Lyubov Zaitseva
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London, UK
    Retrovirology 6:11. 2009
    ..import of the HIV-1 reverse transcription complex (RTC) is critical for infection of non dividing cells, and importin 7 (imp7) has been implicated in this process...
  13. ncbi Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms
    Eiko Saijou
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 282:32327-37. 2007
    ..Taken together, these results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export...
  14. doi Early growth response protein 1 upregulation and nuclear translocation by 2'-benzoyloxycinnamaldehyde induces prostate cancer cell death
    Hye Sook Kang
    Department of Oral Microbiology, School of Dentistry, Kyungpook National University, Daegu 700 412, South Korea
    Cancer Lett 329:217-27. 2013
    ..BCA induces transient upregulation of importin-7 (IPO7) which is critical for EGR1 nuclear translocation, and IPO7 knockdown led to a significant decrease in ..
  15. pmc Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells
    Ji Hoon Jung
    College of Oriental Medicine, Kyung Hee University, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    Evid Based Complement Alternat Med 2013:879746. 2013
    ..viability, attenuated the expression of 45S pre-rRNA and UBF, and consistently downregulated UBF, XPO1 and IPO7, procaspase 3, and Bcl-xL in MDA-MB 231 cells...
  16. pmc Xenopus egg extracts increase dynamics of histone H1 on sperm chromatin
    Benjamin S Freedman
    Molecular and Cell Biology Department, University of California, Berkeley, California, United States of America
    PLoS ONE 5:. 2010
    ..Due to the presence of many other chromatin factors and specific chaperones such as RanBP7/importin beta that regulate histone H1, linker histones likely function differently in vivo than in purified ..
  17. doi Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases
    Eldar Zehorai
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 34:259-70. 2014
    ..We further demonstrate that the translocation requires the stimulated formation of heterotrimers composed of Imp3/Imp7/MAPK or Imp3/Imp9/MAPK...
  18. pmc Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage
    Ho Chul Kang
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:14103-8. 2011
    ..These results define Iduna as a PAR-dependent E3 ligase that regulates cell survival and DNA repair...
  19. doi Cortisol treatment of prespawning female cod affects cytogenesis related factors in eggs and embryos
    Lene Kleppe
    Institute of Marine Research, P O Box 1870, 5817 Bergen, Norway
    Gen Comp Endocrinol 189:84-95. 2013
    ..sel1l3), induction of mesodermal fate (fgfrl1) and import of the glucocorticoid receptor to the cell nucleus (ipo7)...
  20. pmc Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells
    Nikta Pashai
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e39088. 2012
    ..These include IPO7, MED7, RBM26, HSPD1, and KRAS which were upregulated in EGCs along with other pluripotent stem cells when compared ..
  21. doi Identification of ZNF217, hnRNP-K, VEGF-A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma
    Jaroslaw Szczyrba
    Department of Virology, Saarland University Medical School, Homburg Saar, Germany
    Int J Cancer 132:775-84. 2013
    ..Mol Cancer Res 2010;8:529-38). An in silico search predicted that zinc finger protein 217 (ZNF217) and importin 7 (IPO7) were potential target genes of these miRNAs...
  22. pmc Importin-7 mediates nuclear trafficking of DNA in mammalian cells
    Arjun Dhanoya
    The Advanced Centre for Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK
    Traffic 14:165-75. 2013
    ..Here we show that the nuclear transport receptor importin 7 (imp7) supports nuclear import of supercoiled plasmid DNA and human mitochondrial DNA in a Ran and energy-..
  23. pmc Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes
    G Lipowsky
    ZMBH, 69120 Heidelberg, Germany
    EMBO J 19:4362-71. 2000
    ..The export signal in eIF-5A appears to be complex and to involve the hypusine modification that is unique to eIF-5A. We discuss possible cellular roles for nuclear export of eIF-5A...
  24. pmc Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophages
    Steven P Zielske
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    J Virol 79:11541-6. 2005
    In an in vitro assay employing reconstituted nuclei, importin 7 (IPO7) has been implicated in nuclear translocation of human immunodeficiency virus type 1 (HIV-1) cDNA...
  25. ncbi Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily
    U Kutay
    Swiss Federal Institute of Technology Zurich, Institute of Biochemistry, 8092 Zurich, Switzerland
    J Biol Chem 275:40163-8. 2000
    ..Like the other members of the transport receptor superfamily, RanBP16 interacts with the nuclear pore complex and is able to enter the nucleus independent of energy and additional nuclear transport receptors...
  26. pmc Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13
    Joerg Kahle
    Institut fur Biochemie und Molekulare Zellbiologie, Abteilung Molekularbiologie, Universitat Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Mol Cell Biol 25:5339-54. 2005
    ..Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions...
  27. pmc Inhibition of nuclear import by the proapoptotic protein CC3
    Frank W King
    Cancer Research Institute, University of California San Francisco, 94115, USA
    Mol Cell Biol 24:7091-101. 2004
    ..Significantly, a dominant-negative form of importin beta1 shown previously to inhibit multiple transport pathways induces rapid cell death, strongly indicating that inhibition of nuclear transport serves as a potent apoptotic signal...
  28. pmc Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library
    L Y Luo
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Br J Cancer 87:339-43. 2002
    ..protein S18, heat shock protein 90, JK-recombination signal binding protein, ribonucleoprotein H1, RAN binding protein 7, TG-interacting factor, eukaryotic translation initiation factor p40 subunit, human amyloid precursor ..
  29. ncbi The requirement of H1 histones for a heterodimeric nuclear import receptor
    Marc Bauerle
    Institut fur Biochemie und Molekulare Zellbiologie, Abteilung für Molekularbiologie, Universitat Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 277:32480-9. 2002
    ..are imported into the nucleus through an energy-dependent process that can be mediated by an importin beta-importin 7 (Impbeta-Imp7) heterodimer...
  30. pmc Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
    Stefan Jäkel
    ZMBH, INF 282, D 69120 Heidelberg, Germany
    EMBO J 21:377-86. 2002
    ..The same applies to Imp4, Imp5, Imp7 and Impbeta and their respective basic import substrates...
  31. ncbi Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin
    K A Dean
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 114:3479-85. 2001
    ..Our results show that at least one mammalian SRP protein is specifically imported into the nucleus, by members of the importin beta family of transport receptors, and the findings add additional evidence for nuclear assembly of SRP...
  32. ncbi Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)
    A Cichutek
    Department of Pediatrics, University of Mainz, Mainz, Germany
    Cytogenet Cell Genet 93:277-83. 2001
    ..established, proving the conserved order of the genes and markers in both species: "cen-WEE1-D11S2043-ZNF143-RANBP7-CEGF1- ST5-D11S932-LMO1-D11S572-TUB-tel", with inverted order of the murine genes with respect to the telomere/..
  33. ncbi Sequence analysis of two cosmids from Schizosaccharomyces pombe chromosome III
    M Lucas
    Institut National Agronomique, Laboratoire de Genetique Moleculaire et Cellulaire, INRA, CNRS, Centre de Biotechnologies Agro Industrielles, 78850 Thiverval Grignon, France
    Yeast 16:1519-26. 2000
    ..for RNA 3' ss-tail, an UTP-glucose-1-phosphate uridylyltransferase, a leukotriene A(4) hydrolase, a member of the RanBP7-importin beta-Cse1p superfamily, a Ca(++)-calmodulin-dependent serine/threonine protein kinase and a prohibitin ..
  34. ncbi Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts
    F J Nicolas
    Zeneca Laboratory of Molecular and Cellular Biology, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 110:3019-30. 1997
    ..egg extracts with Ran, importin-beta/karyopherin-beta and importin-alpha/karyopherin-alpha, but not p10, p120/RanBP7, RanBP2 or other nucleoporins...
  35. pmc Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
    ..Moreover, knockdown of importin 7 and 8 (Imp7 and 8), the mammalian orthologues of Msk, markedly impaired nuclear accumulation of Smad1 in ..
  36. pmc NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules
    Katharina Ribbeck
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Mol Biol Cell 17:2646-60. 2006
    ..components we show that the activity of NuSAP is differentially regulated by Importin (Imp) alpha, Impbeta, and Imp7. While Impalpha and Imp7 appear to block the microtubule-stabilizing activity of NuSAP, Impbeta specifically ..
  37. pmc Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal
    Yuji Isegawa
    Department of Infectious Disease Control, G 5, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 82:710-8. 2008
    ..These results suggest a relationship between the localization of NPI2/importin-alpha7 and the cell tropism of HHV-6...
  38. pmc Preferential utilization of Imp7/8 in nuclear import of Smads
    Xiaohao Yao
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:22867-74. 2008
    ..We demonstrate that both TGF-beta-induced and basal state spontaneous nuclear import of Smad4 require importin 7 and 8 (Imp7,8)...
  39. ncbi A role for NuSAP in linking microtubules to mitotic chromosomes
    Katharina Ribbeck
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Biol 17:230-6. 2007
    ..NuSAP-chromatin interaction is subject to Ran regulation and can be suppressed by Importin alpha (Impalpha) and Imp7. We propose that the presence of MT binding agents such as NuSAP, which can be directly immobilized on chromatin, ..
  40. pmc ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins
    Shaoyi Huang
    Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Biosci Rep 30:159-68. 2010
    ..Thus ARHI-induced disruption of importin-binding to cargo proteins, including STAT3, could serve as an important regulatory mechanism that contributes to the tumour-suppressor function of ARHI...
  41. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    ..multiple SNPs reaching genome-wide significance for systolic BP in or near the genes: PMS1, SLC24A4, YWHA7, IPO7, and CACANA1H...
  42. doi Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7
    Georgia Chachami
    Laboratory of Biochemistry, School of Medicine, University of Thessaly, Mezourlo, 41110 Larissa, Greece
    Biochem Biophys Res Commun 390:235-40. 2009
    ..Moreover, the interaction of importin 7 with HIF-1alpha is mapped at its N-terminal part encompassing the bHLH-PAS(A) domain...
  43. pmc Identification of novel genes that mediate innate immunity using inbred mice
    Ivana V Yang
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
    Genetics 183:1535-44. 2009
    ..genes that have not previously been implicated in innate immunity, namely, 1110058L19Rik, 4933415F23Rik, Fbxo9, and Ipo7. These genes could represent potential sepsis biomarkers or therapeutic targets that should be further investigated ..
  44. doi Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay
    Lars Dölken
    Max von Pettenkofer Institute, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Cell Host Microbe 7:324-34. 2010
    ..Two genes governing cellular transport processes (TOMM22 and IPO7) were confirmed to be targeted by EBV miRNAs...
  45. pmc Functional comparison of H1 histones in Xenopus reveals isoform-specific regulation by Cdk1 and RanGTP
    Benjamin S Freedman
    Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Curr Biol 20:1048-52. 2010
    ..Nuclear import receptors RanBP7 and importin beta bind tightly to somatic H1 but not H1M, and addition of a constitutively active Ran mutant ..
  46. pmc Specific nucleoporin requirement for Smad nuclear translocation
    Xiaochu Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:4022-34. 2010
    ..Here we identify a subset of nucleoporins that, in conjunction with Msk (Drosophila Imp7/8), specifically mediate activation-induced nuclear translocation of MAD (Drosophila Smad1) but not the ..
  47. doi Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine
    Jinbiao Chen
    Centre for Vascular Research, University of New South Wales, Sydney, NSW, Australia
    Int J Biochem Cell Biol 43:905-12. 2011
    ....

Research Grants12

  1. Receptor Tyrosine Kinase Regulation of Nuclear Import
    Lizabeth Perkins; Fiscal Year: 2004
    ..In a screen for Csw binding proteins, D-Importin 7/RanBP7 (Dim-7), a member of the Importin B superfamily of nuclear import proteins, was identified...
  2. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2007
    ..These regulators of subcellular localization potential targets for therapeutic interventions aimed at modulating TGF-beta signaling diseases such as cancer. ..
  3. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2007
    ..These regulators of subcellular localization of Smad may serve as potential targets for therapeutic interventions aimed at modulating TGF-beta signaling in treatment of diseases such as cancer. ..