Gene Symbol: involucrin
Description: involucrin
Alias: involucrin
Species: human
Products:     involucrin

Top Publications

  1. Welter J, Crish J, Agarwal C, Eckert R. Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J Biol Chem. 1995;270:12614-22 pubmed
    Human involucrin (hINV) is a cornified envelope precursor that is specifically expressed in the suprabasal epidermal layers...
  2. Eckert R, Crish J, Efimova T, Dashti S, Deucher A, Bone F, et al. Regulation of involucrin gene expression. J Invest Dermatol. 2004;123:13-22 pubmed
    ..In this review, we summarize the literature regarding regulation of involucrin, an important marker gene that serves as a model for understanding the mechanisms that regulate the ..
  3. Zhang X, Wu L, Xu R, Zhu C, Ma G, Zhang C, et al. Identification of the molecular relationship between intravenous leiomyomatosis and uterine myoma using RNA sequencing. Sci Rep. 2019;9:1442 pubmed publisher
    ..Our results showed that IVL and UM may have similar dysregulated gene networks. They may be closely related, and HOXA13 may serves as a biomarker to distinguish between IVL and UM. ..
  4. Wong B, El Jack S, Newcombe R, Glenie T, Armstrong G, Khan A. Shockwave Intravascular Lithotripsy for Calcified Coronary Lesions: First Real-World Experience. J Invasive Cardiol. 2019;31:46-48 pubmed
    ..Further study is warranted to compare different calcium modification devices with conventional balloon angioplasty. ..
  5. Ghanem M, Meyer F, Jechorek D, Schoeder V, Ignatov A, Fadel M, et al. Intravascular (post-hysterectomy) leiomyoma (IVL) as late tumor thrombus within the inferior vena cava (IVC)-A rare case primarily imposing as IVC thrombus originating from left renal vein after former left nephrectomy status. Pathol Res Pract. 2019;: pubmed publisher
  6. Holden A. The use of intravascular lithotripsy for the treatment of severely calcified lower limb arterial CTOs. J Cardiovasc Surg (Torino). 2019;60:3-7 pubmed publisher
    ..This is being currently assessed in the DISRUPT PAD III randomized trial. There has also been positive experience in calcified tibial artery CTOs in the DISRUPT BTK trial and further clinical experience is currently being accumulated. ..
  7. Brambilla C, Laffaire J, Lantuejoul S, Moro Sibilot D, Mignotte H, Arbib F, et al. Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. Clin Cancer Res. 2014;20:5777-86 pubmed publisher
    ..In addition, their characteristic molecular profile highlights their intrinsic resistance to cytotoxic chemotherapy and could serve as a guide for targeted therapies. ..
  8. Mohamed L, Shaaban M, Zaher A, Alhamaky S, Elsahar A. Synthesis of new pyrazoles and pyrozolo [3,4-b] pyridines as anti-inflammatory agents by inhibition of COX-2 enzyme. Bioorg Chem. 2018;83:47-54 pubmed publisher
    ..Compounds IVa, IVb and IVc were found to be the most active and selective as COX-2 inhibitors and most effective in protection from edema, they were also found to have lowest ulcerogenic effect among all derivatives. ..
  9. Beaussier M, Delbos A, Maurice Szamburski A, Ecoffey C, Mercadal L. Perioperative Use of Intravenous Lidocaine. Drugs. 2018;78:1229-1246 pubmed publisher
    ..The purpose of this review is to address the pharmacokinetic and pharmacodynamic properties of lidocaine in healthy and pathological conditions. ..

More Information

Publications114 found, 100 shown here

  1. Yang C, Fang H, Yang Y, Cai F, Zheng H, Jin B, et al. Diagnosis and surgical management of inferior vena cava leiomyomatosis. J Vasc Surg Venous Lymphat Disord. 2018;6:636-645 pubmed publisher
    ..Surgical tumor resection with a one-stage operation can lead to reasonable outcomes and successful cure rates. The surgical plan can be tailored to the type of tumor morphology observed on preoperative imaging. ..
  2. Alves A, Ferreira M, Gallego Poveda J, Matos A, Costa Silva A, Nobre A, et al. Intracardiac leiomyomatosis presenting as an intraoperative consultation. Pathol Res Pract. 2016;212:578-81 pubmed publisher
    ..This is the first case report describing an intraoperative consultation of an intracardiac leiomyomatosis. Clinical information and pathologist awareness to this entity are essential for the correct diagnosis in frozen section. ..
  3. Blanchard C, Stucke E, Burwinkel K, Caldwell J, Collins M, Ahrens A, et al. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010;184:4033-41 pubmed publisher
    ..Indeed, expression of the EDC genes filaggrin and involucrin was strongly decreased directly by IL-13...
  4. Yu H, Tsai H, Chi N, Kuo K, Wang S, Chen C, et al. Long-term outcomes of surgical treatment for intravascular leiomyomatosis. J Formos Med Assoc. 2018;117:964-972 pubmed publisher
    ..Concomitant intrapulmonary tumors can be followed up watchfully except when associated with pleural effusion or the pathology indicating trend of increasing malignancy. ..
  5. Alibardi L. Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair. Ann Anat. 2012;194:345-50 pubmed publisher
    The participation of involucrin in the cornification of the human hair has been studied by light and electron microscopy immunohistochemistry...
  6. Neumann C, Bigliardi Qi M, Widmann C, Bigliardi P. The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol. 2015;135:471-480 pubmed publisher
    ..This was accompanied by deregulation of involucrin (IVL), loricrin, and filaggrin...
  7. Tang L, Lu B. Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis. Pathol Res Pract. 2018;214:871-875 pubmed publisher
    ..We conclude that IVL confined to the uterus may have a favorable prognosis, and we believe IVL is likely to originate from contiguous leiomyoma or myometrium. ..
  8. Motov S, Drapkin J, Butt M, Monfort R, Likourezos A, Marshall J. Pain management of renal colic in the emergency department with intravenous lidocaine. Am J Emerg Med. 2018;36:1862-1864 pubmed publisher
    ..Although promising, this therapy will need to be studied in prospective randomized fashion and larger patients' population with underlying cardiac disease before it can be recommended for broad use in the ED. ..
  9. Hassanzadeh H, Matin M, Naderi Meshkin H, Bidkhori H, Mirahmadi M, Raeesolmohaddeseen M, et al. Using paracrine effects of Ad-MSCs on keratinocyte cultivation and fabrication of epidermal sheets for improving clinical applications. Cell Tissue Bank. 2018;19:531-547 pubmed publisher
    ..Besides, this approach has low cost and is easier to perform. However, more in vitro and in vivo experiments as well as safety evaluation required before clinical applications. ..
  10. Rosa P, Pidhorecky I. A Case of Intravenous Leiomyomatosis with Involvement of a Renal Vein. Ann Vasc Surg. 2018;53:271.e11-271.e13 pubmed publisher
  11. Zhang A, Xue M, Wang D, Nie W, Xu D, Guan X. Two-stage resection of a disseminated mixed endometrial stromal sarcoma and smooth muscle tumor with intravascular and intracardiac extension. Taiwan J Obstet Gynecol. 2015;54:776-9 pubmed publisher
  12. Fujii T, Shimada K, Asano A, Tatsumi Y, Yamaguchi N, Yamazaki M, et al. MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2. Int J Mol Sci. 2016;17: pubmed publisher
    ..Quantitative RT-PCR was used to measure the messenger RNA (mRNA) expression of the NRP2, E6, E7, p63, and involucrin (IVL) genes. A functional assay for cell growth was performed using cell cycle analyses...
  13. Dai X, Sayama K, Shirakata Y, Hanakawa Y, Yamasaki K, Tokumaru S, et al. STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation. J Invest Dermatol. 2007;127:1728-35 pubmed
    ..STAT5a expression preceded that of involucrin, an important molecule in the terminal differentiation of keratinocytes...
  14. Fonkem E, Dayawansa S, Stroberg E, Lok E, Bricker P, Kirmani B, et al. Neurological presentations of intravascular lymphoma (IVL): meta-analysis of 654 patients. BMC Neurol. 2016;16:9 pubmed publisher
    ..7%), neurogenic bladder (37.1%), and paresthesia (16.1%) were the most common presentations. CNS complications are more common among IVL patients. Out of these, dementia and seizures outnumber stroke-like presentations. ..
  15. Staikou C, Avramidou A, Ayiomamitis G, Vrakas S, Argyra E. Effects of intravenous versus epidural lidocaine infusion on pain intensity and bowel function after major large bowel surgery: a double-blind randomized controlled trial. J Gastrointest Surg. 2014;18:2155-62 pubmed publisher
    ..05). Compared with LEA-lidocaine or placebo, intravenous lidocaine offered no clinically significant benefit in terms of analgesia and bowel function. ..
  16. Xu R, Miao Q, Liu X, Zhang C, Ma G. Successful One-Stage Operative Resection of an Intravenous Leiomyomatosis Involving the Right-Sided Heart Chambers and Pulmonary Artery. Heart Surg Forum. 2016;19:E064-6 pubmed publisher
    ..The unique feature of this case is its involvement with the pulmonary artery, which is uncommon but potentially lethal. ..
  17. Kur Piotrowska A, Kopcewicz M, Kozak L, Sachadyn P, Grabowska A, Gawronska Kozak B. Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing. BMC Genomics. 2017;18:56 pubmed publisher
    ..E14 and nude mice exhibit prominent up-regulation of keratin (Krt23, -73, -82, -16, -17), involucrin (Ivl) and filaggrin (Flg2) genes...
  18. Zhang G, Yu X, Shi H, Fan Q, Lang J, Liu B. Clinical characteristics and prognostic features of intravenous leiomyomatosis with inferior vena cava or intracardiac extension. J Vasc Surg Venous Lymphat Disord. 2017;5:485-492 pubmed publisher
    ..Surgery is the primary treatment. The postoperative recurrence rate is high, and postoperative antiestrogen hormone therapy is not significantly correlated with recurrence. ..
  19. Senra H, Barbosa F, Ferreira P, Vieira C, Perrin P, Rogers H, et al. Psychologic adjustment to irreversible vision loss in adults: a systematic review. Ophthalmology. 2015;122:851-61 pubmed publisher
    ..Specific factors and variables associated with the adjustment to IVL need to be clarified through further in-depth and longitudinal research. ..
  20. Chiang C, Chen P, Kuo T, Chen I, Wu N, Chang H. One-stage surgery for removal of intravascular leiomyomatosis extending to right ventricle. Medicine (Baltimore). 2018;97:e0051 pubmed publisher
    ..The patient tolerated the surgical procedure well and no postoperative complication was noted. We describe a one-stage surgical approach to completely remove an IVL extending to the right ventricle. ..
  21. Uehara Y, Ito T, Ogawa Y, Hirotaki S, Shoji T, Tame T, et al. Molecular epidemiologic study of community-associated methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin gene among family members in Japan. J Infect Chemother. 2015;21:700-2 pubmed publisher
  22. Chen J, Tang W, Che J, Chen K, Yan G, Gu Y, et al. Synthesis and Biological Activity Evaluation of Novel α-Amino Phosphonate Derivatives Containing a Pyrimidinyl Moiety as Potential Herbicidal Agents. J Agric Food Chem. 2015;63:7219-29 pubmed publisher
    ..Their preliminary herbicidal mode of action and structure-activity relationships were also studied. ..
  23. MacFater W, Xia W, Barazanchi A, Su a B, Svirskis D, Hill A. Intravenous Local Anaesthetic Compared with Intraperitoneal Local Anaesthetic in Abdominal Surgery: A Systematic Review. World J Surg. 2018;42:3112-3119 pubmed publisher
    ..Further research investigating IVL combined with intraperitoneal local anaesthetic is warranted. ..
  24. Kano R, Masaie H, Hino A, Yasuoka H, Nagata S, Ishikawa J, et al. Pure intravascular recurrence of CD5-positive diffuse large B-cell lymphoma primarily arising from the nasal cavities. Diagn Pathol. 2018;13:46 pubmed publisher
    ..Bone marrow smears showed hemophagocytosis. We present a rare case of primary CD5-positive DLBCL that relapsed as pure IVL after chemotherapy. Our case suggests that CD5-positive DLBCL is closely related to IVL. ..
  25. AlHumidi A. Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review. Diagn Pathol. 2015;10:107 pubmed publisher
    ..Because this type of lymphoma is extremely rare, our case is documented and compared with the previously reported cases. ..
  26. Hashimoto Hachiya A, Tsuji G, Murai M, Yan X, Furue M. Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1. Int J Mol Sci. 2018;19: pubmed publisher
    ..OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE)...
  27. Li Y, Mei F, Yang C, Lv P, Ouyang C, Jin B. Intravenous leiomyomatosis with right heart involvement-a report of 4 cases and literature review. J Huazhong Univ Sci Technolog Med Sci. 2011;31:586 pubmed publisher
    ..Three of them suffered recurrent sudden syncope, and the other one was totally asymptomatic. All of them were successfully treated through one-stage operation under extracorporeal circulation. ..
  28. Kwon O, Yoo H, Han J, Lee S, Chung J, Eun H. Photoaging-associated changes in epidermal proliferative cell fractions in vivo. Arch Dermatol Res. 2008;300:47-52 pubmed
    ..The aim of this study was to validate involucrin/beta1-integrin ratio as a molecular marker of epidermal photoaging, and to investigate the effects of photoaging ..
  29. Sapkota B, HOPKINS R, Bjonnes A, Ralhan S, Wander G, Mehra N, et al. Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study. J Steroid Biochem Mol Biol. 2016;158:149-156 pubmed publisher
    ..Identification of novel association signals in biologically plausible regions with 25(OH)D metabolism will provide new molecular insights on genetic drivers of vitamin D status and its implications in health disparities. ..
  30. Sato T, Usui M, Konishi N, Kai A, Matsui H, Hanaki H, et al. Closely related methicillin-resistant Staphylococcus aureus isolates from retail meat, cows with mastitis, and humans in Japan. PLoS ONE. 2017;12:e0187319 pubmed publisher
    ..These results suggest that there is a transmission cycle of CA-MRSA/J among meat, cows, and humans in Japan, although it is unclear whether the origin is cow...
  31. Mizoguchi C, Matsumoto H, Nasu K, Arakane M, Kai K, Narahara H. Intravenous leiomyomatosis treated with radical hysterectomy and adjuvant aromatase inhibitor therapy. J Obstet Gynaecol Res. 2016;42:1405-1408 pubmed publisher
    ..Radical hysterectomy can be considered a successful therapy for total resection. Aromatase inhibitor treatment may be effective, especially when the patient has not yet entered menopause. ..
  32. Harnoy Y, Rayar M, Levi Sandri G, Zamreek A, Turner K, Sulpice L, et al. Intravascular Leiomyomatosis with Intracardiac Extension. Ann Vasc Surg. 2016;30:306.e13-5 pubmed publisher
    ..Perioperative transfusion included two plasma and two red blood cells units. No adjuvant treatment was administered. Follow-up with annual CT scans was performed. Patient had no signs of recurrence after 3 years. ..
  33. Huynh J, Scholz G, Aw J, Reynolds E. Interferon Regulatory Factor 6 Promotes Keratinocyte Differentiation in Response to Porphyromonas gingivalis. Infect Immun. 2017;85: pubmed publisher
    ..g., involucrin [IVL] and keratin 13 [KRT13]), together with additional transcriptional regulators of keratinocyte ..
  34. Hatta M, Naganuma K, Kato K, Yamazaki J. 3-Deazaneplanocin A suppresses aggressive phenotype-related gene expression in an oral squamous cell carcinoma cell line. Biochem Biophys Res Commun. 2015;468:269-73 pubmed publisher
    ..Collectively, our findings suggest that DZNep reverses the aggressive characteristics of OSCC cells through the dynamic regulation of epithelial plasticity via the reprogramming of gene expression patterns. ..
  35. Gui T, Qian Q, Cao D, Yang J, Peng P, Shen K. Computerized tomography angiography in preoperative assessment of intravenous leiomyomatosis extending to inferior vena cava and heart. BMC Cancer. 2016;16:73 pubmed publisher
  36. Brunel I, Iacoponi S, Hernandez A, Diestro M, De Santiago J, Zapardiel I. Intravascular leiomyomatosis: an exceptional entity. Clin Exp Obstet Gynecol. 2016;43:443-5 pubmed
    ..The association of antiestrogenic drugs can be useful for disease control, especially in cases where oophorectomy is not performed and the tumor cannot be removed completely. ..
  37. Rice R, Green H. Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions. Cell. 1979;18:681-94 pubmed
    ..The protein is also concentrated in a peripheral location in cultured epidermal cells. ..
  38. Qi F, Yoshida T, Koike T, Aizawa H, Shimane T, Li Y, et al. Construction and characterization of human oral mucosa equivalent using hyper-dry amniotic membrane as a matrix. Arch Oral Biol. 2016;65:26-34 pubmed publisher
    ..The OME with HD-AM as a matrix revealed a good morphology and stable wound healing. This study demonstrates that HD-AM is a useful and feasible biomaterial for oral mucosa reconstruction. ..
  39. Xiao J, Liu G, Cheng D, Wang H, Shi H. The value of (18)F-FDG PET/CT in the diagnosis of uterine intravenous leiomyomatosis extended into the right atrium. Hell J Nucl Med. 2016;19:179-81 pubmed publisher
    ..The IVL was detected in the right atrium. This case highlights the usefulness of (18)F-FDG PET/CT in the diagnosis of IVL. ..
  40. Wang H, Nie P, Chen B, Hou F, Dong C, He F, et al. Contrast-enhanced CT findings of intravenous leiomyomatosis. Clin Radiol. 2018;73:503.e1-503.e6 pubmed publisher
    ..Contrast-enhanced CT can demonstrate tumour location and full-scale extension pathway, which are important for diagnosis, surgical planning, and follow-up of the tumour. ..
  41. Weisse T, Bergkemper V. Rapid detection and quantification of the potentially toxic cyanobacterium Planktothrix rubescens by in-vivo fluorometry and flow cytometry. Water Res. 2018;138:234-240 pubmed publisher
    ..rubescens in the upper surface waters and on the peak concentration of P. rubescens within the water column. We conclude that the protocol that we developed is superior to the current monitoring practice. ..
  42. Efthimiadis C, Petousis S, Grigoriou M, Ioannidis A, Tzouveleki I, Margioula Siarkou C, et al. Successful multiple-step management of intravenous leiomyomatosis diagnosed after episode of acute abdominal pain: Case report and review of literature. Int J Surg Case Rep. 2015;14:176-8 pubmed publisher
    ..IVL represents a rare clinical entity often presenting difficulties in diagnosis and optimal treatment. Large case-series studies should be encouraged to assess the optimal management. ..
  43. Schäfer H, Isaak A, Gurke L. Case report of an intracaval leiomyomatosis 10 months after complete hysterectomy. Int J Surg Case Rep. 2017;35:1-3 pubmed publisher
    ..2016). The SCARE Statement: Consensus-based surgical case report guidelines. Agha RA, Fowler AJ, Saeta A, Barai I, Rajmohan S, Orgill DP; SCARE Group. Int J Surg. 2016 Oct;34:180-186 [1]. ..
  44. Suzuki Y, Tanaka H, Suyama K, Mochida H, Suzuki Y. Secondary Central Nerve System Lymphoma With Intratumoral Hemorrhage Suggested as Intravascular Lymphoma by Autopsy: A Case Report. J Clin Med Res. 2017;9:953-957 pubmed publisher
    ..Although many patients with IVL have rapidly progressive courses, it is very important to diagnose IVL at the initial onset, even in serious situations, to consider CNS prophylaxis...
  45. Abraham L, Kreipe H, Raab P, Hussein K. [Clinical and pathological characteristics of intravascular lymphomas]. Pathologe. 2018;39:242-248 pubmed publisher
    ..Because of the rarity of this disease, little is known about therapy and prognosis, whereby therapy is mainly similar to non-IVL lymphomas. The prognosis is poor; median survival after diagnosis is approximately one year. ..
  46. Crish J, Gopalakrishnan R, Bone F, Gilliam A, Eckert R. The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression. J Invest Dermatol. 2006;126:305-14 pubmed
    b>Involucrin is a marker of human keratinocyte differentiation. Previous studies show that the human involucrin gene promoter has two distinct regulatory regions - the proximal regulatory region (PRR) and the distal regulatory region (DRR)...
  47. Micallef L, Belaubre F, Pinon A, Jayat Vignoles C, Delage C, Charveron M, et al. Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes. Exp Dermatol. 2009;18:143-51 pubmed publisher G0/G1 phase and expression of epidermal differentiation markers, such as keratin 1 (K1), keratin 10 (K10) and involucrin. In vitro, the spontaneously immortalized human keratinocyte cell line HaCaT is often used as a model to study ..
  48. Crish J, Bone F, Banks E, Eckert R. The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation. Oncogene. 2002;21:738-47 pubmed
    Human involucrin (hINV) is a keratinocyte protein that is expressed in the suprabasal compartment of the epidermis and other stratifying surface epithelia...
  49. Schindler E, Baumgartner M, Gribben E, Li L, Efimova T. The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes. J Invest Dermatol. 2007;127:1094-106 pubmed
    ..Our data show that Pyk2 increases promoter activity and endogenous protein levels of involucrin, a marker of keratinocyte terminal differentiation...
  50. Lee C, Marekov L, Kim S, Brahim J, Park M, Steinert P. Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. FEBS Lett. 2000;477:268-72 pubmed
    ..reveal that the CEs contain 60-70% small proline-rich protein 1a/b (SPR1a/b), together with smaller amounts of involucrin, annexin I and several other known CE proteins...
  51. Kim B, Leung D, Boguniewicz M, Howell M. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin Immunol. 2008;126:332-7 pubmed publisher
    ..Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity...
  52. Zhang Z, Yang Y, Bai S, Zhang G, Liu T, Zhou Z, et al. Screening for key genes associated with atopic dermatitis with DNA microarrays. Mol Med Rep. 2014;9:1049-55 pubmed publisher
    ..95E-07), including loricrin (LOR), keratin 17 (KRT17), small proline-rich repeat proteins (SPRRs) and involucrin (IVL). The chemokine signaling pathway was the most significantly enriched pathway (P=0...
  53. Castagneto Gissey L, Mariano G, Musleh L, Lepiane P, Colasanti M, Meniconi R, et al. Massive pelvic recurrence of uterine leiomyomatosis with intracaval-intracardiac extension: video case report and literature review. BMC Surg. 2017;17:118 pubmed publisher
  54. Noguchi K, Wakai K, Kiyono T, Kawabe M, Yoshikawa K, Hashimoto Tamaoki T, et al. Molecular analysis of keratocystic odontogenic tumor cell lines derived from sporadic and basal cell nevus syndrome patients. Int J Oncol. 2017;51:1731-1738 pubmed publisher
    ..The similarities in protein expression patterns between the two cell lines suggested that common mechanisms underlie the development of both types of KCOT and a probable common origin of KCOT cells...
  55. Takahashi H, Iizuka H. Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate. J Invest Dermatol. 1993;100:10-5 pubmed
    b>Involucrin is one of the precursor proteins of keratinocyte cornified envelope...
  56. Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M, Finazzi Agro A, et al. Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro. J Biol Chem. 2001;276:35014-23 pubmed
    ..indicate that full-length TGase 5 is very efficient in using specific epidermal substrates (loricrin, involucrin, and SPR3)...
  57. Crish J, Eckert R. Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex. J Invest Dermatol. 2008;128:530-41 pubmed
    b>Involucrin is expressed in the differentiated suprabasal epidermal layers, and an AP1 transcription factor-binding site present in the involucrin promoter distal regulatory region is required for this regulation...
  58. Coolen N, Schouten K, Middelkoop E, Ulrich M. Comparison between human fetal and adult skin. Arch Dermatol Res. 2010;302:47-55 pubmed publisher
    ..and adult skin biopsies, the expression patterns of several epidermal proteins (K10, K14, K16, K17, SKALP, involucrin), basement membrane proteins, Ki-67, blood vessels and extracellular matrix proteins (fibronectin, chondroitin ..
  59. Yaffe M, Beegen H, Eckert R. Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope. J Biol Chem. 1992;267:12233-8 pubmed
    b>Involucrin is a 68-kDa precursor of the keratinocyte cornified envelope...
  60. Gyöngyösi E, Szalmás A, Ferenczi A, Konya J, Gergely L, Veress G. Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes. Virol J. 2012;9:36 pubmed publisher
    ..Here, we aimed to study the effects of HPV16 E6 and E7 oncogenes on the expression of involucrin (IVL), an established marker of keratinocyte differentiation, in human foreskin keratinocyte (HFK) cells...
  61. Pomoni A, Sotiriadis C, Gay F, Jouannic A, Qanadli S. Percutaneous endovascular biopsy of intravascular masses: efficacy and safety in establishing pre-therapy diagnosis. Eur Radiol. 2018;28:301-307 pubmed publisher
    ..Endovascular biopsy provides tissue samples leading to correct histopathological analysis. • Percutaneous endovascular biopsy provides early diagnosis of malignant intravascular lesions. ..
  62. Banks E, Crish J, Welter J, Eckert R. Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites. Biochem J. 1998;331 ( Pt 1):61-8 pubmed
    Human involucrin (hINV) is an important precursor of the keratinocyte cornified envelope that is specifically expressed in the suprabasal layers of stratifying epithelia...
  63. Dugu L, Nakahara T, Wu Z, Uchi H, Liu M, Hirano K, et al. Neuronatin is related to keratinocyte differentiation by up-regulating involucrin. J Dermatol Sci. 2014;73:225-31 pubmed publisher
    ..To unveil a possible integration of Nnat in controlling the keratinocyte differentiation markers such as involucrin, cytokeratin1, filaggrin, loricrin and S100A7...
  64. Hisatsune J, Hagiya H, Shiota S, Sugai M. Complete Genome Sequence of Systemically Disseminated Sequence Type 8 Staphylococcal Cassette Chromosome mec Type IVl Community-Acquired Methicillin-Resistant Staphylococcus aureus. Genome Announc. 2017;5: pubmed publisher
    ..Here, we present the complete genome sequence of the chromosome and a plasmid harboring the se1 and ednA genes. ..
  65. Balasubramanian S, Eckert R. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J Biol Chem. 2004;279:24007-14 pubmed
    ..EGCG), a green tea polyphenol antioxidant, stimulates expression of the keratinocyte differentiation marker, involucrin (hINV), via a Ras, MEKK1, MEK3, p38delta signaling cascade (Balasubramanian, S., Efimova, T., and Eckert, R. L...
  66. Jans R, Atanasova G, Jadot M, Poumay Y. Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J Invest Dermatol. 2004;123:564-73 pubmed
    ..that cholesterol depletion induces downregulation of keratin 14 (K14) and keratin 10 (K10) and upregulation of involucrin. MbetaCD treatment induces phosphorylation of EGFR, HER2, and ERK, but not HER3...
  67. Oh J, Kook J, Min B. Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway. J Biol Chem. 2005;280:21629-37 pubmed
    ..effectively inhibited keratinocyte differentiation by decreasing the promoter activities and thus expression of involucrin and transglutaminase. The result was an approximately 2-fold increase in mitotic capacity of the cells...
  68. Tong L, Corrales R, Chen Z, Villarreal A, de Paiva C, Beuerman R, et al. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006;47:1938-46 pubmed
    ..Tissue distribution of small proline-rich proteins (SPRRs) and filaggrin and involucrin was studied in human cornea sections by immunofluorescence staining...
  69. Takahashi H, Kobayashi H, Matsuo S, Iizuka H. Repression of involucrin gene expression by transcriptional enhancer factor 1 (TEF-1). Arch Dermatol Res. 1995;287:740-6 pubmed
    b>Involucrin is one of the precursor proteins of keratinocyte cornified envelope that is formed beneath the inner surface of the cell membrane during terminal differentiation...
  70. Balasubramanian S, Zhu L, Eckert R. Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J Biol Chem. 2006;281:36162-72 pubmed
    ..Expression of involucrin (hINV), a marker of keratinocyte differentiation, is increased by differentiating agents via a protein kinase ..
  71. Ivanova P, Atanasova G, Poumay Y, Mitev V. Knockdown of PKD1 in normal human epidermal keratinocytes increases mRNA expression of keratin 10 and involucrin: early markers of keratinocyte differentiation. Arch Dermatol Res. 2008;300:139-45 pubmed publisher
    ..mRNA levels of different keratinocyte markers -- K14 and PCNA (markers of basal proliferating keratinocytes), involucrin and K10 (early differentiation markers) were analyzed...
  72. Crish J, Zaim T, Eckert R. The distal regulatory region of the human involucrin promoter is required for expression in epidermis. J Biol Chem. 1998;273:30460-5 pubmed
    Human involucrin (hINV) is a precursor of the keratinocyte cornified envelope that is specifically expressed in the suprabasal layers of stratifying squamous epithelia...
  73. Lee S, Crabb S, Janghra N, Carlberg C, Williams A, Cutress R, et al. Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis. Exp Cell Res. 2007;313:3222-38 pubmed
    ..and enhanced VDR-dependent transcription and protein expression of the keratinocyte differentiation marker, involucrin. These results demonstrate endogenous gene regulation by BAG-1L by potentiating nuclear hormone receptor ..
  74. Kitazawa K, Hikichi T, Nakamura T, Sotozono C, Kinoshita S, Masui S. PAX6 regulates human corneal epithelium cell identity. Exp Eye Res. 2017;154:30-38 pubmed publisher
    ..transketolase (TKT), while up-regulated genes were primarily epidermis-related and included keratin 10, keratin 1, involucrin (IVL), filaggrin (FLG). These findings suggest that PAX6 maintains CEC identity by regulating differentiation.
  75. Yoon H, Li Z, Choi D, Sohn K, Lim E, Lee Y, et al. Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner. Mol Cell Biochem. 2014;390:289-95 pubmed publisher
    ..Overexpression of GR using an adenovirus showed that expression of involucrin, an early differentiation marker of keratinocytes, was markedly increased due to GR overexpression...
  76. di Fonzo H, Contardo D, Carrozza D, Finocchietto P, Rojano Crisson A, Cabral C, et al. Intravascular Large B Cell Lymphoma Presenting as Fever of Unknown Origin and Diagnosed by Random Skin Biopsies: A Case Report and Literature Review. Am J Case Rep. 2017;18:482-486 pubmed
    ..In this case, the diagnosis was made with cutaneous biopsies of visibly unaffected skin. As in our patient, the course of IVL is usually fatal within a few months...
  77. Kassem H, Beier J, El Sawaf B. Historical overview of infantile visceral leishmaniasis in El Agamy, Alexandria, Egypt. Acta Trop. 2017;176:335-339 pubmed publisher
    ..langeroni. In this review, we characterize the old focus of IVL in El Agamy based on published literature to identify factors underlying the appearance and disappearance of the disease. ..
  78. Heller M, Flemington E, Kieff E, Deininger P. Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat. Mol Cell Biol. 1985;5:457-65 pubmed
    ..Each of the repeats is a distinct variation, perhaps diverged from a common sequence, (GGA)n. This family is present in the genomes of all species tested and appears to be a ubiquitous feature of all higher eucaryotic genomes. ..
  79. Zhu L, Brodie C, Balasubramanian S, Eckert R. Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311. J Invest Dermatol. 2008;128:833-45 pubmed
    Protein kinase C-delta (PKCdelta) is a key regulator of human involucrin (hINV) gene expression and is regulated by tyrosine phosphorylation...
  80. Kubo E, Fatma N, Sharma P, Shinohara T, Chylack L, Akagi Y, et al. Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF). J Mol Biol. 2002;320:1053-63 pubmed
    Human involucrin (hINV), first appears in the cytosol of keratinocytes and ultimately cross-linked to membrane proteins via transglutaminase and forms a protective barrier as an insoluble envelope beneath the plasma membrane...
  81. Volz A, Korge B, Compton J, Ziegler A, Steinert P, Mischke D. Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21. Genomics. 1993;18:92-9 pubmed
    ..05 Mb of DNA. The order is calpactin I light chain, trichohyalin, profilaggrin, involucrin/small proline-rich protein, loricrin, and calcyclin...
  82. Hadjadj J, Nielly H, Piekarski E, Cuccuini W, Deau Fischer B, Hourseau M, et al. Uterine intravascular lymphoma as a cause of fever of unknown origin. Ann Hematol. 2017;96:1891-1896 pubmed publisher
    ..Normal structural imaging does not rule out the diagnosis and 18FDG-TEP/CT should be performed to guide high-yielding biopsy. ..
  83. Barcelos A, Sotto M. Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions. J Cutan Pathol. 2009;36:647-54 pubmed publisher
    ..Epidermodysplasia verruciformis (EV) is a rare genodermatosis with susceptibility to human papillomavirus (HPV) infection, and high risk of skin cancer considered a model of viral oncogenesis...
  84. Uzuka T, Higuchi F, Matsuda H, Otani R, Kim P, Ueki K. Intravascular Lymphoma with an Acute Course of Cerebellar Hemorrhage: A Case Report. Neurol Med Chir (Tokyo). 2017;: pubmed publisher
    ..The dilated veins on the cerebellar surface recognized from the Gd-enhanced T1-weighted images were specific clues in this case...
  85. Steinert P, Marekov L. Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. J Biol Chem. 1997;272:2021-30 pubmed
    b>Involucrin was the first protein to be identified as a likely constituent of the insoluble cornified cell envelope (CE) of stratified squamous epithelia...
  86. Adhikary G, Crish J, Lass J, Eckert R. Regulation of involucrin expression in normal human corneal epithelial cells: a role for activator protein one. Invest Ophthalmol Vis Sci. 2004;45:1080-7 pubmed
    ..In the present study, the involucrin gene was used as a model to study this regulation...
  87. Michibata H, Chiba H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, et al. Identification and characterization of a novel component of the cornified envelope, cornifelin. Biochem Biophys Res Commun. 2004;318:803-13 pubmed directly or indirectly cross-linked to at least two other cornified envelope proteins, loricrin and involucrin, in vivo...
  88. El Ghalbzouri A, Lamme E, Ponec M. Crucial role of fibroblasts in regulating epidermal morphogenesis. Cell Tissue Res. 2002;310:189-99 pubmed
    ..The expression of involucrin or transglutaminase 1 showed a similar pattern as for the keratins...
  89. Bikle D, Ng D, Oda Y, Hanley K, Feingold K, Xie Z. The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2002;119:1109-13 pubmed
    b>Involucrin is a major protein of the cornified envelope of keratinocytes that provides much of the structural integrity of skin...
  90. Efimova T, Broome A, Eckert R. A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem. 2003;278:34277-85 pubmed
    ..increased levels of AP1 and CAATT enhancer binding protein factors, increased binding of these factors to the involucrin (hINV) promoter, and increased expression...
  91. Eckert R, Green H. Structure and evolution of the human involucrin gene. Cell. 1986;46:583-9 pubmed
    b>Involucrin is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. The gene for human involucrin has now been cloned and sequenced...
  92. Robinson N, Lapic S, Welter J, Eckert R. S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. J Biol Chem. 1997;272:12035-46 pubmed
    ..envelope precursors, as well as portions of the well established CE precursor proteins SPR1A, SPR1B, and involucrin. Many desmosomal components were identified (desmoglein 3, desmocolin A/B, desmoplakin I, plakoglobin, and ..