intestinal alkaline phosphatase

Summary

Gene Symbol: intestinal alkaline phosphatase
Description: alkaline phosphatase, intestinal
Alias: IAP, intestinal-type alkaline phosphatase, Kasahara isozyme, alkaline phosphomonoesterase, glycerophosphatase, intestinal alkaline phosphatase
Species: human

Top Publications

  1. Le Du M, Millan J. Structural evidence of functional divergence in human alkaline phosphatases. J Biol Chem. 2002;277:49808-14 pubmed
    ..e. intestinal (IAP), germ cell (GCAP), and placental AP (PLAP)...
  2. Goldberg R, Austen W, Zhang X, Munene G, Mostafa G, Biswas S, et al. Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A. 2008;105:3551-6 pubmed publisher
    ..Using in vitro and in vivo models, we demonstrate that the brush-border enzyme, intestinal alkaline phosphatase (IAP), has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut ..
  3. Guo Y, Jiang W, Wu P, Liu Y, Zhou X, Kuang S, et al. The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngod. Fish Shellfish Immunol. 2017;65:145-168 pubmed publisher
    ..the mRNA levels of B-cell lymphoma-2 (Bcl-2), myeloid cell leukemia 1 (Mcl-1), and inhibitor of apoptosis protein (IAP), and decreased activities and mRNA levels of antioxidant enzymes, down-regulated the mRNA levels of NF-E2-related ..
  4. Wu P, Tian L, Zhou X, Jiang W, Liu Y, Jiang J, et al. Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2018;73:121-132 pubmed publisher
    ..mRNA levels, up-regulated the B-cell lymphoma protein-2 (Bcl-2) (rather than PI), inhibitor of apoptosis proteins (IAP) and myeloid cell leukemia-1 (Mcl-1) mRNA levels in the intestine (P < 0...
  5. Wu P, Zheng X, Zhou X, Jiang W, Liu Y, Jiang J, et al. Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2018;74:459-473 pubmed publisher
    ..factor-1 (Apaf-1) and Fas ligand (FasL), and down-regulated the mRNA levels of inhibitor of apoptosis proteins (IAP), B-cell lymphoma protein-2 (Bcl-2) and myeloid cell leukaemia-1 (Mcl-1) (P?<?...
  6. Li S, Jiang W, Feng L, Liu Y, Wu P, Jiang J, et al. Dietary myo-inositol deficiency decreased the growth performances and impaired intestinal physical barrier function partly relating to nrf2, jnk, e2f4 and mlck signaling in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2017;67:475-492 pubmed publisher
    ..kinase (jnk) mRNA levels, whereas down-regulated B-cell lymphoma-2 (bcl-2), inhibitor of apoptosis proteins (iap) and myeloid cell leukemia-1 (mcl-1) mRNA levels in three intestinal segments of young grass carp (P < 0.05)...
  7. Guo Y, Wu P, Jiang W, Liu Y, Kuang S, Jiang J, et al. The impaired immune function and structural integrity by dietary iron deficiency or excess in gill of fish after infection with Flavobacterium columnare: Regulation of NF-?B, TOR, JNK, p38MAPK, Nrf2 and MLCK signalling. Fish Shellfish Immunol. 2018;74:593-608 pubmed publisher
    ..Second, iron deficiency down-regulated the mRNA levels of inhibitor of apoptosis protein (IAP) and myeloid cell leukemia 1 (Mcl-1), decreased activities and mRNA levels of antioxidant enzymes, down-regulated ..
  8. Conde M, Michen S, Wiedemuth R, Klink B, Schrock E, Schackert G, et al. Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells. BMC Cancer. 2017;17:889 pubmed publisher
    Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundantly expressed in tumors...
  9. Ni P, Jiang W, Wu P, Liu Y, Kuang S, Tang L, et al. Dietary low or excess levels of lipids reduced growth performance, and impaired immune function and structure of head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella) under the infection of Aeromonas hydrophila. Fish Shellfish Immunol. 2016;55:28-47 pubmed publisher
    ..levels of lipids down-regulated the mRNA levels of B-cell lymphoma-2 (Bcl-2) and inhibitor of apoptosis protein (IAP) in the head kidney and spleen, whereas up-regulated the mRNA levels of apoptotic protease activating factor-1 (..

More Information

Publications147 found, 100 shown here

  1. Gundamaraju R, Vemuri R, Chong W, Myers S, Norouzi S, Shastri M, et al. Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells. Cells. 2018;7: pubmed publisher
    ..of apoptosis, in contrast, is a mechanism adopted by cancer cells with the help of the inhibitor of an apoptosis (IAP) class of proteins such as Survivin to evade cell death and gain a proliferative advantage...
  2. Lallès J. Dairy products and the French paradox: Could alkaline phosphatases play a role?. Med Hypotheses. 2016;92:7-11 pubmed publisher
    ..First, intestinal alkaline phosphatase (IAP), a potent endogenous anti-inflammatory enzyme, is directly stimulated by various components of ..
  3. Song G, Valdez B, Li Y, Liu Y, Champlin R, Andersson B. Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FMS-like tyrosine kinase 3 internal tandem duplications-positive acute myeloid leukemia cells. Biol Blood Marrow Transplant. 2014;20:1687-95 pubmed publisher
    ..by 60% and caused leakage of cytochrome c, second mitochondria-derived activator of caspases (SMAC)/direct IAP Binding protein with low pI (DIABLO), and AIF from the mitochondria to the cytoplasm, caspase activation, and cell ..
  4. Ji J, Yu Y, Li Z, Chen M, Deng R, Huang X, et al. XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells. Theranostics. 2018;8:1494-1510 pubmed publisher
    ..b>Results: IAPs, especially X chromosome-linked IAP (XIAP), were elevated in CSCs of NPC, and these proteins were critically involved in the maintenance of CSCs ..
  5. Gilani S, Howarth G, Nattrass G, Kitessa S, Barekatain R, Forder R, et al. Gene expression and morphological changes in the intestinal mucosa associated with increased permeability induced by short-term fasting in chickens. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..in enterocyte protection including glucagon-like peptide (GLP-2), heat-shock protein (HSP-70), intestinal alkaline phosphatase (IAP), mammalian target of rapamycin (mTOR), toll-like receptors (TLR-4), mucin (MUC-2), cluster ..
  6. Jiang L, Wu X, Wang P, Wen T, Yu C, Wei L, et al. Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 2015;141:971-81 pubmed publisher
    ..growth and induce apoptosis of LSCC through mitochondrial- and caspase-dependent intrinsic pathway and Fas-dependent extrinsic pathway as well as IAP family. Thiostrepton may represent a novel lead compound for targeted therapy of LSCC.
  7. Lagat D, Delong A, Wellenius G, Carter E, Bloomfield G, Velazquez E, et al. Factors associated with isolated right heart failure in women: a pilot study from western Kenya. Glob Heart. 2014;9:249-54 pubmed publisher
    ..kitchen ventilation, fuel use, and cook smoke exposure time, all surrogate measures of indoor air pollution (IAP). A total of 31 cases and 65 control subjects were enrolled...
  8. Osman K, Samir A, Abo Shama U, Mohamed E, Orabi A, Zolnikov T. Determination of virulence and antibiotic resistance pattern of biofilm producing Listeria species isolated from retail raw milk. BMC Microbiol. 2016;16:263 pubmed
    ..The virulence-associated genes, hlyA, plcB, actA and iap associated with Listeria were molecularly assayed. The 17 isolated Listeria spp. represented a prevalence rate of 8...
  9. Vivekanandan L, Sheik H, Singaravel S, Thangavel S. Ameliorative effect of silymarin against linezolid-induced hepatotoxicity in methicillin-resistant Staphylococcus aureus (MRSA) infected Wistar rats. Biomed Pharmacother. 2018;108:1303-1312 pubmed publisher
    ..linezolid treated rats also showed myelosuppression, lactic acidosis, oxidative stress and decreased intestinal alkaline phosphatase (IAP)...
  10. Divarci E, Karapinar B, Yalaz M, Ergun O, Celik A. Incidence and prognosis of intraabdominal hypertension and abdominal compartment syndrome in children. J Pediatr Surg. 2016;51:503-7 pubmed publisher
    ..IAH was defined by a sustained or repeated pathological elevation in IAP≥12mmHg without a new organ failure...
  11. Park G, Jeong J, Kim D. Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1 signaling. Oncol Lett. 2017;14:7947-7956 pubmed publisher
    ..and SB203580 (a p38-MAPK inhibitor) effectively inhibited apoptosis and attenuated the expression of X-linked IAP-associated factor 1 (XAF1) and apoptotic Bcl-2 family proteins (BCL2 antagonist/killer 1 and BCL2-associated X ..
  12. Biradar S, Tamboli A, Khandare R, Pawar P. Chebulinic acid and Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress. Mitochondrion. 2019;46:236-246 pubmed publisher
    ..However, CA and BB triggered the expression of Sir2. Similarly, MG lowered the expression of Baculoviral IAP repeat (Bir1) which is the inhibitor of apoptosis while CA and BB aided the over expression of Bir1...
  13. Ashour A, Ahmed A, Kumar A, Zoheir K, Aboul Soud M, Ahmad S, et al. Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-?B signaling and IL-8 expression. Mol Cell Biochem. 2016;416:141-55 pubmed publisher
    ..and altered expression of its downstream effectors IL-8 and its receptors, the anti-apoptotic Bcl-2, Bcl-xL, X-IAP, and FLIP, as well as the pro-apoptotic TRAIL-R1, caspase-8, caspase-9, Bcl-xS, and cytochrome c...
  14. Rogers W, Garcia L. Intraabdominal Hypertension, Abdominal Compartment Syndrome, and the Open Abdomen. Chest. 2018;153:238-250 pubmed publisher
    ..Once IAH is recognized, nonsurgical steps to decrease intraabdominal pressure (IAP) can be undertaken (diuresis/dialysis, evacuation of intraluminal bowel contents, and sedation), although the ..
  15. Sahoo S, Singh P, Kalha B, Singh O, Pal R. Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets. BMC Cancer. 2015;15:931 pubmed publisher
    ..and/or expression of molecular intermediates (SURVIVIN, HIF-1α, PARP-1, Bcl-2, c-FLIP, KLK-10, XIAP, c-IAP-1) associated with chemo-resistance and increased levels of stress modulators (PON2, HO-1, HSP27 and NRF-2)...
  16. Scheer A, Knauer S, Verhaegh R. Survivin expression pattern in the intestine of normoxic and ischemic rats. BMC Gastroenterol. 2017;17:76 pubmed publisher
    Survivin, a member of the inhibitor of apoptosis protein (IAP) family, regulates mitosis and chromosome segregation...
  17. Abhari B, McCarthy N, Le Berre M, Kilcoyne M, Joshi L, Agostinis P, et al. Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress. Cell Death Dis. 2019;10:155 pubmed publisher
    Since Inhibitor of Apoptosis (IAP) proteins have been implicated in cellular adaptation to endoplasmic reticulum (ER) stress, we investigated the regulation of ER stress-induced apoptosis by small-molecule second mitochondria-derived ..
  18. Feng L, Ni P, Jiang W, Wu P, Liu Y, Jiang J, et al. Decreased enteritis resistance ability by dietary low or excess levels of lipids through impairing the intestinal physical and immune barriers function of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2017;67:493-512 pubmed publisher
    ..not JNK)/MLCK signaling molecules, down-regulating B-cell lymphoma-2 (Bcl-2) and inhibitor of apoptosis protein (IAP) and up-regulating the mRNA levels of apoptotic protease activating factor-1 (Apaf-1), Caspase-3, -8 and -9 and Fas ..
  19. Tanabe T, Otani H, Bao L, Mikami Y, Yasukura T, Ninomiya T, et al. Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils. Eur J Pharmacol. 1996;299:187-95 pubmed
    ..G-protein) inactivators such as guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) and islet-activating protein (IAP), or a phospholipase C inhibitor, 1-[6-[[17 beta-3-methoxyestra-1,3,5(10)- trien-17-yl]amino]hexyl]1 H-pyrrole-2,5-..
  20. Zhang Z, Wang H, Jin Z, Cai X, Gao N, Cui X, et al. Downregulation of survivin regulates adult hippocampal neurogenesis and apoptosis, and inhibits spatial learning and memory following traumatic brain injury. Neuroscience. 2015;300:219-28 pubmed publisher
    Survivin, a unique member of the inhibitor of the apoptosis protein (IAP) family, has been suggested to play a crucial role in promoting the cell cycle and mediates mitosis during embryonic development...
  21. Liu B, Pan C, Ma T, Wang J, Yao G, Wei K, et al. Long non?coding RNA AK001796 contributes to cisplatin resistance of non?small cell lung cancer. Mol Med Rep. 2017;16:4107-4112 pubmed publisher
    ..The expression levels of cell cycle proteins cyclin C (CCNC), baculoviral IAP repeat containing 5 (BIRC5), cyclin?dependent kinase 1 (CDK1) and G2 and S phase?expressed 1 (GTSE1) were ..
  22. Olaniran A, Nzimande S, Mkize N. Antimicrobial resistance and virulence signatures of Listeria and Aeromonas species recovered from treated wastewater effluent and receiving surface water in Durban, South Africa. BMC Microbiol. 2015;15:234 pubmed publisher
    ..26.92% were found to contain virulence genes, with 14.10, 5.12 and 21% harbouring the actA, plcA and iap genes, respectively. Of the 100 tested Aeromonas spp...
  23. Sachdeva A, Jain P, Gunasekaran V, Mahay S, Mukherjee S, Hagerman R, et al. Consensus Statement of the Indian Academy of Pediatrics on Diagnosis and Management of Fragile X Syndrome in India. Indian Pediatr. 2019;56:221-228 pubmed
    ..This necessitated the formulation of IAP recommendations for the diagnosis and management of FXS in Indian children and adolescents...
  24. Prabhu V, Talekar M, Lulla A, Kline C, Zhou L, Hall J, et al. Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Cell Cycle. 2017;:1-29 pubmed publisher
    ..response (ATF4/CHOP) pathway, inhibition of Akt phosphorylation, Foxo3a activation, downregulation of cyclin D1, IAP and Bcl-2 family members...
  25. Kołpa M, Wałaszek M, Gniadek A, Wolak Z, Dobroś W. Incidence, Microbiological Profile and Risk Factors of Healthcare-Associated Infections in Intensive Care Units: A 10 Year Observation in a Provincial Hospital in Southern Poland. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..6% and 29.0% infections per 1000 ICU days. Intubation-associated pneumonia (IAP) posed the greatest risk (15.2 per 1000 ventilator days), followed by CLA-BSI (8...
  26. Hani Y, Turies C, Palluel O, Delahaut L, Gaillet V, Bado Nilles A, et al. Effects of chronic exposure to cadmium and temperature, alone or combined, on the threespine stickleback (Gasterosteus aculeatus): Interest of digestive enzymes as biomarkers. Aquat Toxicol. 2018;199:252-262 pubmed publisher
    ..e. energy reserves (glycogen, lipids, proteins) and digestive enzymes (trypsin, amylase, intestinal alkaline phosphatase -IAP-), and (iii) biometric parameters (weight, length, Fulton's condition factor, and the ..
  27. Wicki S, Gurzeler U, Wei Lynn Wong W, Jost P, Bachmann D, Kaufmann T. Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils. Cell Death Dis. 2016;7:e2422 pubmed publisher
    ..Besides its antiapoptotic role, the inhibitor of apoptosis protein (IAP) family member X-linked IAP (XIAP) has been shown to regulate innate immune signaling...
  28. Garrison J, Ge C, Che L, Pullum D, Peng G, Khan S, et al. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. J Cancer Sci Ther. 2015;7:121-126 pubmed
    ..BRUCE (BIR repeat containing ubiquitin-conjugating enzyme) is a member of the inhibitor of apoptosis protein (IAP) family. It has various cellular functions including suppression of apoptosis and promotion of cytokinesis...
  29. El Khattouti A, Selimovic D, Hannig M, Taylor E, Abd Elmageed Z, Hassan S, et al. Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition. J Cell Mol Med. 2016;20:266-86 pubmed publisher
    ..the activation of NF-κB and the expression of the inhibitor of apoptosis proteins (IAPs) such as, X-linked IAP (XIAP) together with the accumulation of reactive oxygen species (ROS)...
  30. Zappavigna S, Scuotto M, Cossu A, Ingrosso D, De Rosa M, Schiraldi C, et al. The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells. J Exp Clin Cancer Res. 2016;35:167 pubmed
    ..mitochondrial membrane potential; array analysis showed a significant upregulation of CASP8 and a downregulation of IAP family and NFκB genes in cells treated with RF-Id...
  31. Gressot L, Doucette T, Yang Y, Fuller G, Manyam G, Rao A, et al. Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma. Oncotarget. 2017;8:12695-12704 pubmed publisher
    ..Here, we investigated the role of the remaining members of the Inhibitors of Apoptosis (IAP) family on promoting MT in glioma...
  32. Zhang R, Zhang L, Yang M, Huang L, Chen G, Feng Z. Potential role of microRNA?223?3p in the tumorigenesis of hepatocellular carcinoma: A comprehensive study based on data mining and bioinformatics. Mol Med Rep. 2017;: pubmed publisher
    ..the hub genes of miR?223?3p in HCC, including checkpoint kinase 1, DNA methyltransferase 1, baculoviral IAP repeat containing 5, kinesin family member 23, and collagen, type I, ?1...
  33. Goldenshluger M, Zippel D, Ben Yaacov A, Dux J, Yalon T, Zendel A, et al. Core Body Temperature but Not Intraabdominal Pressure Predicts Postoperative Complications Following Closed-System Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Administration. Ann Surg Oncol. 2018;25:660-666 pubmed publisher
    ..cytoreductive surgery (CRS), performed using closed-abdomen technique (CAT), may affect intraabdominal pressure (IAP)...
  34. Roerink F, Morgan C, Knetter S, Passat M, Archibald A, Ait Ali T, et al. A novel inactivated vaccine against Lawsonia intracellularis induces rapid induction of humoral immunity, reduction of bacterial shedding and provides robust gut barrier function. Vaccine. 2018;36:1500-1508 pubmed publisher
    ..barrier was evaluated to quantify a range of intestinal markers including secreted mucin and intestinal alkaline phosphatase, and innate immune markers including Caspase-3 and Calprotectin...
  35. Rump A, Kasper G, Hayes C, Wen G, Starke H, Liehr T, et al. Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1. Genomics. 2001;73:50-5 pubmed
  36. Fawley J, Gourlay D. Intestinal alkaline phosphatase: a summary of its role in clinical disease. J Surg Res. 2016;202:225-34 pubmed publisher
    Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders...
  37. Pachera P, Pavan P, Todros S, Cavinato C, Fontanella C, Natali A. A numerical investigation of the healthy abdominal wall structures. J Biomech. 2016;49:1818-1823 pubmed publisher
    ..The evaluation of a normal range of intra-abdominal pressure (IAP) during activities of daily living is fundamental because pressure alterations can cause several adverse effects...
  38. Marchegiani G, Andrianello S, Borin A, Dal Borgo C, Perri G, Pollini T, et al. Systematic review, meta-analysis, and a high-volume center experience supporting the new role of mural nodules proposed by the updated 2017 international guidelines on IPMN of the pancreas. Surgery. 2018;163:1272-1279 pubmed publisher
    ..MNs are reliable predictors of iCa and HGD in IPMNs as proposed by the 2016 IAP guidelines...
  39. Hauge T, Nilsson A, Persson J, Hultberg B. Gamma-glutamyl transferase, intestinal alkaline phosphatase and beta-hexosaminidase activity in duodenal biopsies from chronic alcoholics. Hepatogastroenterology. 1998;45:985-9 pubmed
    Gamma-glutamyl transferase (GGT) and intestinal alkaline phosphatase (IAP) are present in the brush border of mucosal absorptive cells in the small intestine. There are few studies on the effect of alcohol consumption on these enzymes...
  40. Praveenraj P, Gomes R, Kumar S, Senthilnathan P, Parthasarathi R, Rajapandian S, et al. Concomitant Bariatric Surgery with Laparoscopic Intra-peritoneal Onlay Mesh Repair for Recurrent Ventral Hernias in Morbidly Obese Patients: an Evolving Standard of Care. Obes Surg. 2016;26:1191-4 pubmed publisher
    ..The chronic increase in intra-abdominal pressure (IAP) associated with obesity might, in part, be an important implicating factor that needs to be addressed in these ..
  41. Byers N, Vandergaast R, Friesen P. Baculovirus Inhibitor-of-Apoptosis Op-IAP3 Blocks Apoptosis by Interaction with and Stabilization of a Host Insect Cellular IAP. J Virol. 2016;90:533-44 pubmed publisher
    Baculovirus-encoded inhibitor of apoptosis (IAP) proteins likely evolved from their host cell IAP homologs, which function as critical regulators of cell death...
  42. Perimenis P, Galaris A, Voulgari A, Prassa M, Pintzas A. IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis. BMC Cancer. 2016;16:624 pubmed publisher
    ..activity of new SMAC-mimetics Birinapant and AT-406 is evaluated against colorectal adenocarcinoma cells and IAP cross-talk with either oncogenic BRAF or BCL-2, or with the TRAIL are further exploited towards rational combined ..
  43. Thansa K, Yocawibun P, Suksodsai H. The cellular death pattern of primary haemocytes isolated from the black tiger shrimp (Penaeus monodon). Fish Shellfish Immunol. 2016;57:243-251 pubmed publisher
    ..75 ± 1.30%) and late apoptotic cells (15.47 ± 11.71%) determined by Annexin V and TUNEL including constant IAP (0.06 ± 0.01-0.07 ± 0.01) and caspase-3 expression (0.30 ± 0.06-0.39 ± 0...
  44. Beug S, Beauregard C, Healy C, Sanda T, St Jean M, Chabot J, et al. Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma. Nat Commun. 2017;8: pubmed publisher
    Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-?-induced killing while simultaneously blocking TNF-? growth-promoting activities...
  45. Hinnebusch B, Siddique A, Henderson J, Malo M, Zhang W, Athaide C, et al. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol. 2004;286:G23-30 pubmed
    ..Krüppel-like factor (KLF4 or GKLF) plays in activating the enterocyte differentiation marker gene intestinal alkaline phosphatase (IAP)...
  46. Naing S, Vukoti K, Drury J, Johnson J, Kalyoncu S, Hill S, et al. Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay. ACS Chem Biol. 2015;10:2166-74 pubmed publisher
    ..We developed a FRET peptide assay for the intramembrane aspartyl protease (IAP) from Methanoculleus marisnigri JR1 in combination with quantitative mass spectrometry cleavage site analysis...
  47. Wang S, Xu Y, Chan H, Kim H, Wang Y, Leong K, et al. Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy. J Control Release. 2016;240:454-464 pubmed publisher
    ..Upregulated expression of inhibitors of apoptosis proteins (IAP) has been implicated in drug resistance in several cancers...
  48. Hannes S, Abhari B, Fulda S. Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. Cancer Lett. 2016;380:31-8 pubmed publisher
    ..that the second mitochondrial activator of caspases (Smac) mimetic BV6 that antagonizes inhibitor of apoptosis (IAP) proteins induces necroptosis in PC cells in which apoptosis is blocked by the caspase inhibitor zVAD.fmk...
  49. Nogacka A, Salazar N, Suarez M, Milani C, Arboleya S, Solis G, et al. Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates. Microbiome. 2017;5:93 pubmed publisher
    ..are among the drugs most frequently used in early life, the use of intrapartum antimicrobial prophylaxis (IAP), present in over 30% of deliveries, being the most frequent source of exposure...
  50. Cutrignelli M, Messina M, Tulli F, Randazzo B, Olivotto I, Gasco L, et al. Evaluation of an insect meal of the Black Soldier Fly (Hermetia illucens) as soybean substitute: Intestinal morphometry, enzymatic and microbial activity in laying hens. Res Vet Sci. 2018;117:209-215 pubmed publisher
    ..In the duodenum, the maltase exhibited a higher (P<0.05) activity in the HILM group while the intestinal alkaline phosphatase (IAP) had a higher (P<0.05) activity in the SBM group...
  51. Hehlgans S, Oppermann J, Reichert S, Fulda S, Rödel C, Rödel F. The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. Radiat Oncol. 2015;10:198 pubmed publisher
    In the present study, we aimed to investigate the effect of counteracting inhibitor of apoptosis (IAP) proteins using the small molecule Second Mitochondria-derived Activator of Caspase (SMAC) mimetic BV6 in combination with ionizing ..
  52. Kobayashi T, Masaki T, Nozaki E, Sugiyama M, Nagashima F, Furuse J, et al. Microarray Analysis of Gene Expression at the Tumor Front of Colon Cancer. Anticancer Res. 2015;35:6577-81 pubmed
    ..ligand (CXCL)9-11, and interleukin 8 (IL8)], and two apoptosis-related molecules [ubiquitin D (UBD) and baculoviral iap repeat-containing 3 (BIRC3)]...
  53. Cruz R, Morais C, Cardoso A, Silva S, Vale M, Marques E, et al. Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes. Eur J Pharm Biopharm. 2016;104:7-18 pubmed publisher
    ..In this context, the inhibitor-of-apoptosis protein (IAP) survivin emerges as an ideal target for a gene silencing approach, since it is sharply differentially expressed in ..
  54. Deniz O, de la Rica L, Cheng K, Spensberger D, Branco M. SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells. Genome Biol. 2018;19:6 pubmed publisher
    ..We find that in the absence of SETDB1, TET2 activates IAP elements in a catalytic-dependent manner...
  55. Liu Y, Wang G, Cui H, Li X, Xu Z, Wang X. miRNA211 induces apoptosis of cervical cancer SiHa cells via down-regulation of inhibitor of apoptosis proteins. Eur Rev Med Pharmacol Sci. 2018;22:336-342 pubmed publisher
    ..Groups of miRNA (NC), miRNA211, miRNA+siRNA IAP, miRNA211+siRNA IAP were established and levels of IAP and caspase 3 from each group were measured after ..
  56. De Maria A, Bassnett S. Birc7: A Late Fiber Gene of the Crystalline Lens. Invest Ophthalmol Vis Sci. 2015;56:4823-34 pubmed publisher
    ..Expression of Livin, a member of the inhibitor of apoptosis protein (IAP) family encoded by Birc7, was strongly upregulated in deep cortical fiber cells...
  57. Sun D, Wang X, Sui G, Chen S, Yu M, Zhang P. Downregulation of miR-374b-5p promotes chemotherapeutic resistance in pancreatic cancer by upregulating multiple anti-apoptotic proteins. Int J Oncol. 2018;: pubmed publisher
    ..demonstrated that miR-374b-5p targeted several anti-apoptotic proteins, including B-cell lymphoma 2, Baculoviral IAP Repeat Containing 3 and X-linked inhibitor of apoptosis in pancreatic cancer cells, which further attenuated ..
  58. Balkhi M, Fitzgerald K, Pitha P. IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway. Cell Signal. 2010;22:117-27 pubmed publisher
  59. Derakhshan A, Chen Z, Van Waes C. Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways. Clin Cancer Res. 2017;23:1379-1387 pubmed publisher
    ..amplification and overexpression of the Fas-associated via death domain (FADD) and inhibitor of apoptosis proteins (IAP) that complex with members of the TNF receptor family...
  60. Hikami S, Shiozaki A, Kitagawa Juge M, Ichikawa D, Kosuga T, Konishi H, et al. The Role of cIAP1 and XIAP in Apoptosis Induced by Tumor Necrosis Factor Alpha in Esophageal Squamous Cell Carcinoma Cells. Dig Dis Sci. 2017;62:652-659 pubmed publisher
    The inhibitor of apoptosis protein (IAP) family are reported to play important roles in cancer cells evading apoptosis...
  61. Ohoka N, Shibata N, Hattori T, Naito M. Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy. Curr Cancer Drug Targets. 2016;16:136-46 pubmed
    ..a protein knockdown technology with a series of hybrid small compounds, called SNIPERs (Specific and Nongenetic IAP-dependent Protein ERasers); and peptidic chimeric molecules, called PROTACs (proteolysis-targeting chimeric ..
  62. Caesar Y, Sidlovskaja I, Lindqvist A, Gislason H, Hedenbro J. Intraabdominal Pressure and Postoperative Discomfort in Laparoscopic Roux-en-Y Gastric Bypass (RYGB) Surgery: a Randomized Study. Obes Surg. 2016;26:2168-2172 pubmed publisher
    High intraabdominal pressure (IAP) during laparoscopic surgery has been associated with postoperative discomfort. Effects on nausea and access have not been subjected to randomized studies...
  63. Miles M, Shekhar T, Hall N, Hawkins C. TRAIL causes deletions at the HPRT and TK1 loci of clonogenically competent cells. Mutat Res. 2016;787:15-31 pubmed publisher
    ..Physiologically achievable concentrations of direct apoptosis inducing anti-cancer drugs that target Bcl-2 and IAP proteins possess negligible mutagenic activity, however death receptor agonists like TRAIL/Apo2L can provoke ..
  64. Dehant V, Asael D, Baland R, Baludikay B, Béghin J, Belza J, et al. PLANET TOPERS: Planets, Tracing the Transfer, Origin, Preservation, and Evolution of their ReservoirS. Orig Life Evol Biosph. 2016;46:369-384 pubmed
    The Interuniversity Attraction Pole (IAP) 'PLANET TOPERS' (Planets: Tracing the Transfer, Origin, Preservation, and Evolution of their Reservoirs) addresses the fundamental understanding of the thermal and compositional evolution of the ..
  65. Ramakrishnan V, Gomez M, Prasad V, Kimlinger T, Painuly U, Mukhopadhyay B, et al. Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma. Oncotarget. 2016;7:56253-56265 pubmed publisher
    Bcl2 and IAP families are anti-apoptotic proteins deregulated in multiple myeloma (MM) cells. Pharmacological inhibition of each of these families has shown significant activity only in subgroups of MM patients...
  66. Hatem J, Schrank Hacker A, Watt C, Morrissette J, Rubin A, Kim E, et al. Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report. Diagn Pathol. 2016;11:137 pubmed
    ..a novel deletion of the long arm of chromosome 20 (del(20q12)) and a missense mutation in BIRC3 (Baculoviral IAP repeat-containing protein 3) in this patient's DLBCL that are absent from his MZL, suggesting that these genetic ..
  67. Guo H, Zhong W, Wang X, Pan B, Li F, Lu K, et al. Expression and clinical significance of Apollon in renal carcinoma. Oncol Lett. 2016;12:5129-5135 pubmed publisher
    Apollon, namely baculoviral inhibitor of apoptosis proteins (IAP) repeat containing 6, is an unusually large member of the IAP family, and may be important in oncogenesis...
  68. Rotondo F, Ho Palma A, Remesar X, Fernández López J, Romero M, Alemany M. Glycerol is synthesized and secreted by adipocytes to dispose of excess glucose, via glycerogenesis and increased acyl-glycerol turnover. Sci Rep. 2017;7:8983 pubmed publisher
    ..b>Glycerophosphatase expression was not affected by incubation...
  69. Feltham R, Moulin M, Vince J, Mace P, Wong W, Anderton H, et al. Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. J Biol Chem. 2010;285:17525-36 pubmed publisher
    ..They are targeted by IAP antagonist compounds that are undergoing clinical trials...
  70. Jin G, Lan Y, Han F, Sun Y, Liu Z, Zhang M, et al. Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer. Mol Med Rep. 2016;13:359-66 pubmed publisher
    ..Second mitochondrial‑derived activator of caspase/direct IAP‑binding protein with low PI is a natural IAP antagonist, which is found in the mitochondrion; this protein ..
  71. Clavier A, Rincheval Arnold A, Colin J, Mignotte B, Guénal I. Apoptosis in Drosophila: which role for mitochondria?. Apoptosis. 2016;21:239-51 pubmed publisher
    ..These proteins participate in the cell death process at different levels such as degradation of Diap1, a Drosophila IAP, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery...
  72. Trojian T, Concoff A, Joy S, Hatzenbuehler J, Saulsberry W, Coleman C. AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes. Br J Sports Med. 2016;50:84-92 pubmed publisher
    ..hyaluronic acid, HA) versus steroid (intra-articular corticosteroids, IAS) and placebo (intra-articular placebo, IAP) is based on the evaluation of treatment effect by examining the number of participants within a treatment arm who ..
  73. Peters E, Heuberger J, Tiessen R, van Elsas A, Masereeuw R, Arend J, et al. Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers. Clin Pharmacokinet. 2016;55:1227-1237 pubmed publisher
    Previous clinical trials have suggested that bovine intestinal alkaline phosphatase has renal protective effects in patients with sepsis-associated acute kidney injury...
  74. Vanker A, Barnett W, Nduru P, Gie R, Sly P, Zar H. Home environment and indoor air pollution exposure in an African birth cohort study. Sci Total Environ. 2015;536:362-367 pubmed publisher
    Household indoor air pollution (IAP) is a global health problem and a risk factor for childhood respiratory disease; the leading cause of mortality in African children...
  75. Wang D, Berglund A, Kenchappa R, Forsyth P, Mulé J, Etame A. BIRC3 is a novel driver of therapeutic resistance in Glioblastoma. Sci Rep. 2016;6:21710 pubmed publisher
    ..Inhibitors of apoptosis proteins (IAP) exert critical control on the terminal segment of apoptosis leading to apoptosis evasion...
  76. Lin N, Xiong L, Zhang R, Zheng H, Wang L, Qian Z, et al. Injection of Aβ1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew. Apoptosis. 2016;21:621-40 pubmed publisher
    ..was associated with downregulated BCL-2/BCL-XL-associated death promoter (Bad), inhibitor of apoptosis protein (IAP), Cytochrome c (CytC) and upregulated tumor necrosis factor receptor 1 (TNF-R1); lastly, gene sequencing reported a ..
  77. Chudasama R, Eshwar T, Eshwar S, Thakkar D. Prevalence of Obesity and Overweight Among School Children Aged 8-18 Years in Rajkot, Gujarat. Indian Pediatr. 2016;53:743-4 pubmed
    ..Prevalence of obesity and overweight was estimated by using three different growth standards. Revised IAP 2015 growth standards detected more obese and overweight children than WHO 2007 and IOTF standards.
  78. Pilling A, Hwang O, Boudreault A, Laurent A, Hwang C. IAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration-Resistant Prostate Cancer Cells via Autocrine TNF-? Signaling. Prostate. 2017;77:866-877 pubmed publisher
    ..Novel, small-molecule IAP antagonists, such as AEG40995, are emerging as a strategy to induce apoptosis and increase therapeutic response in ..
  79. Lehnen D, Barral S, Cardoso T, Grealish S, Heuer A, Smiyakin A, et al. IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells. Stem Cell Reports. 2017;9:1207-1220 pubmed publisher
    ..Here, we demonstrate that integrin-associated protein (IAP) is a cell surface marker suitable for enrichment of hPSC-derived mesDA progenitor cells...
  80. Wang Y, Lin H, Tong X, Hou Y, Chang Y, Zhang J. DNA demethylation activates genes in seed maternal integument development in rice (Oryza sativa L.). Plant Physiol Biochem. 2017;120:169-178 pubmed publisher
    ..methylated genes revealed extensive occurrence of DNA hypomethylation triggered by double fertilization at IAP compared with IBP, suggesting that DNA demethylation might be a key mechanism to activate numerous maternal ..
  81. Agodi A, Barchitta M, Quattrocchi A, Spera E, Gallo G, Auxilia F, et al. Preventable proportion of intubation-associated pneumonia: Role of adherence to a care bundle. PLoS ONE. 2017;12:e0181170 pubmed publisher
    The aim of the present study was to estimate the preventable proportion of Intubation-Associated Pneumonia (IAP) in the Intensive Care Units (ICUs) participating in the Italian Nosocomial Infections Surveillance in ICUs (SPIN-UTI) ..
  82. Voelcker G. Influence of the alkylating function of aldo-Ifosfamide on the anti-tumor activity. Anticancer Drugs. 2018;29:75-79 pubmed publisher
    ..apoptotic antitumor activity of oxazaphosphorine cytostatics using I-aldophosphamide-perhydrothiazine (IAP) and mesyl-I-aldophosphamide-perhydrothiazine (SUM-IAP) for in-vitro and in-vivo experiments...
  83. Knoll B, Rothblum K, Longley M. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. Gene. 1987;60:267-76 pubmed
    ..phosphatase (AP) isoenzymes in man: a heat-stable placental enzyme (PLAP), a less heat-stable intestinal form (IAP), and the very heat-labile AP enriched in liver, bone and kidney...
  84. Le Doaré K, O Driscoll M, Turner K, Seedat F, Russell N, Seale A, et al. Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review. Clin Infect Dis. 2017;65:S143-S151 pubmed publisher
    Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world...
  85. Olsen L, Bressendorff S, Troelsen J, Olsen J. Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G220-6 pubmed
    The intestinal alkaline phosphatase gene (ALPI) encodes a digestive brush-border enzyme, which is highly upregulated during small intestinal epithelial cell differentiation...
  86. Pan F, Han L, Zhang Y, Yu Y, Liu J. Optimization of Caco-2 and HT29 co-culture in vitro cell models for permeability studies. Int J Food Sci Nutr. 2015;66:680-5 pubmed publisher
    ..So we concluded that 9:1 (Caco-2:HT29) is the optimal Caco-2 to HT29 ratio in the in vitro model co-culture for permeability studies. ..
  87. Chao C, Tsai C, Wang Y, Liu Y, Chen J, Chang Y, et al. Original Research: Porcine model for observing changes due to ischemia/reperfusion injury secondary to intra-abdominal endovascular balloon occlusion. Exp Biol Med (Maywood). 2016;241:1834-43 pubmed publisher
    ..Using a porcine model, we evaluated the influence of different EBO time periods on intra-abdominal pressure (IAP) and the association between various pathophysiologic indicators and reperfusion time...
  88. Jiang Y, Meng Q, Chen B, Shen H, Yan B, Sun B. The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 2016;478:293-299 pubmed publisher
    In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins)...
  89. Huang C, Zeng X, Jiang G, Liao X, Liu C, Li J, et al. XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. J Hematol Oncol. 2017;10:6 pubmed publisher
    ..Anti-IAP therapy is reported to be closely related to epidermal growth factor receptor (EGFR) expression level...
  90. Fulda S. Smac Mimetics to Therapeutically Target IAP Proteins in Cancer. Int Rev Cell Mol Biol. 2017;330:157-169 pubmed publisher
    Inhibitor of Apoptosis (IAP) proteins are overexpressed in a variety of human cancers. Therefore, they are considered as promising targets for the design of therapeutic strategies...
  91. Seedat F, Stinton C, Patterson J, Geppert J, Tan B, Robinson E, et al. Adverse events in women and children who have received intrapartum antibiotic prophylaxis treatment: a systematic review. BMC Pregnancy Childbirth. 2017;17:247 pubmed publisher
    Adverse events from intrapartum antibiotic prophylaxis (IAP) are poorly documented yet essential to inform clinical practice for neonatal group B Streptococcus (GBS) disease prevention...
  92. Morozov D, Morozova O, Pervouchine D, Severgina L, Tsyplakov A, Zakharova N, et al. Hypoxic renal injury in newborns with abdominal compartment syndrome (clinical and experimental study). Pediatr Res. 2017;: pubmed publisher
    ..MethodsIntra-abdominal pressure (IAP), renal excretory function, and the biomarker levels were analyzed before, 4, and 10 days after surgery...