interleukin 2

Summary

Gene Symbol: interleukin 2
Description: interleukin 2
Alias: IL-2, TCGF, lymphokine, T cell growth factor, aldesleukin, interleukin-2, involved in regulation of T-cell clonal expansion
Species: human

Top Publications

  1. doi Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    S Adamovic
    Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Genes Immun 9:364-7. 2008
  2. pmc Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
    Garima Garg
    Department of Immunobiology, School of Medicine, King s College London, London SE1 9RT, United Kingdom
    J Immunol 188:4644-53. 2012
  3. pmc Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo
    Tao Zou
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 189:28-32. 2012
  4. ncbi Family based association analysis of the IL2 and IL15 genes in allergic disorders
    Ulla Christensen
    Institute of Human Genetics, The Bartholin Building, University of Aarhus, Aarhus C, Denmark
    Eur J Hum Genet 14:227-35. 2006
  5. doi G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Clin Immunol 129:36-9. 2008
  6. ncbi Allelic expression and interleukin-2 polymorphisms in multiple sclerosis
    F Matesanz
    Department of Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla 11, 18001, Granada, Spain
    J Neuroimmunol 119:101-5. 2001
  7. pmc Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
    Deborah J Stauber
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2788-93. 2006
  8. ncbi Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    R Moriggl
    Howard Hughes Medical Institute, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 10:249-59. 1999
  9. pmc Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states
    Urban Sester
    Department of Internal Medicine IV, Saarland University, Homburg, Germany
    PLoS ONE 6:e17813. 2011
  10. pmc A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy
    Simone C Wuest
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 17:604-9. 2011

Detail Information

Publications282 found, 100 shown here

  1. doi Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    S Adamovic
    Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Genes Immun 9:364-7. 2008
    ..001 and 0.002, respectively). However, we found no association with the FcgammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region...
  2. pmc Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
    Garima Garg
    Department of Immunobiology, School of Medicine, King s College London, London SE1 9RT, United Kingdom
    J Immunol 188:4644-53. 2012
    ..These data offer a rationale that contributes to the molecular and cellular mechanisms through which polymorphisms in the IL-2RA gene affect immune regulation, and consequently upon susceptibility to autoimmune and inflammatory diseases...
  3. pmc Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo
    Tao Zou
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 189:28-32. 2012
    ..These findings also have therapeutic implications, as TCR signaling by Tregs may not be required when using IL-2 to increase Treg numbers for treatment of inflammatory disorders...
  4. ncbi Family based association analysis of the IL2 and IL15 genes in allergic disorders
    Ulla Christensen
    Institute of Human Genetics, The Bartholin Building, University of Aarhus, Aarhus C, Denmark
    Eur J Hum Genet 14:227-35. 2006
    ..We suggest that the observed overtransmission of the T allele of this SNP may convey increased susceptibility to allergic disease by skewing the Th1/Th2 balance towards Th2...
  5. doi G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Clin Immunol 129:36-9. 2008
    ..01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE...
  6. ncbi Allelic expression and interleukin-2 polymorphisms in multiple sclerosis
    F Matesanz
    Department of Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla 11, 18001, Granada, Spain
    J Neuroimmunol 119:101-5. 2001
    ..These data indicate for the first time the relevance of the il-2 gene locus in human MS and its possible involvement in other autoimmune diseases...
  7. pmc Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
    Deborah J Stauber
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2788-93. 2006
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes...
  8. ncbi Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    R Moriggl
    Howard Hughes Medical Institute, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Immunity 10:249-59. 1999
    ..These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2 signaling in T cells...
  9. pmc Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states
    Urban Sester
    Department of Internal Medicine IV, Saarland University, Homburg, Germany
    PLoS ONE 6:e17813. 2011
    ..In conclusion, a frequency lower than 56% IFN-γ/IL-2 dual positive PPD-specific circulating CD4 T-cells is strongly indicative of active TB...
  10. pmc A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy
    Simone C Wuest
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 17:604-9. 2011
    ..Our data reveal a previously unknown mechanism for the IL-2 receptor system in DC-mediated activation of T cells...
  11. ncbi Structure and expression of a cloned cDNA for human interleukin-2
    T Taniguchi
    Nature 302:305-10. 1983
    ..A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells...
  12. ncbi Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease
    Rama Devi Mittal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India
    Immunogenetics 59:159-65. 2007
    ..Further, combined analysis implicated a higher risk in ESRD patients with low IL-4 and high IL-6 producing genotypes. This study provided the basis for defined anti-inflammatory approaches to limit renal disease progression...
  13. pmc Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells
    Zsuzsanna S Nagy
    Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, United States of America
    PLoS ONE 8:e57326. 2013
    ....
  14. pmc IL-2 regulates expression of C-MAF in human CD4 T cells
    Aradhana Rani
    Department of Immunobiology, King s College London, London SE1 9RT, United Kingdom
    J Immunol 187:3721-9. 2011
    ..Thus, our findings demonstrate the importance of IL-2 in Th2 differentiation in human T cells and support the notion that IL-2R-directed therapies may have utility in the treatment of allergic disorders...
  15. pmc Newly identified genetic risk variants for celiac disease related to the immune response
    Karen A Hunt
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Nat Genet 40:395-402. 2008
    ..Type 1 diabetes and celiac disease share HLA-DQ, IL2-IL21, CCR3 and SH2B3 risk regions. Thus, this extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways...
  16. ncbi Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma
    Yao Yuan Hsieh
    Department of Obstetrics and Gynecology, National Chiao Tung University, Hsinchu, Taiwan
    Fertil Steril 87:886-95. 2007
    ..e., interleukin (IL)-1, IL-2, IL-4, IL-8, IL-12, and IL-18, which are all immunomodulatory cytokines that play important roles in host immune responses against cancers...
  17. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008
    ..Thus, there are intrinsic signaling differences between IL-2 and IL-15 that can be attributed to differences in activation of the PI3K pathway...
  18. ncbi Shock waves increase T-cell proliferation or IL-2 expression by activating p38 MAP kinase
    Tie Cheng Yu
    Department of Orthopedics, The First Teaching Hospital of Jilin University, Changchun 130021, China
    Acta Biochim Biophys Sin (Shanghai) 36:741-8. 2004
    ..We concluded that the p38 MAPK activation played a key role in the regulation of T cells function by the LDSWs...
  19. pmc Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor
    S M Zurawski
    DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304 1104
    EMBO J 12:5113-9. 1993
    ..The relative spatial locations of these three surfaces are different from the two receptor binding sites known for the structurally related human growth hormone and the significance of this observation is discussed...
  20. ncbi Genetic variants in interleukin-2 and risk of lymphoma among children in Korea
    Nan Song
    Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea
    Asian Pac J Cancer Prev 13:621-3. 2012
    ..TT=3.43 (1.29-9.11), P(trend)=0.002, minP=0.005). These findings suggest that common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma...
  21. ncbi Allelic selection of human IL-2 gene
    F Matesanz
    Departamento de Biología Celular e Inmunología, Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Eur J Immunol 30:3516-21. 2000
    ..These findings may be used as a suitable marker for monitoring the IL-2 allelic contribution to effector activities and in immune responses against different infections or in pathological situations...
  22. ncbi Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway
    M Ott
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Science 275:1481-5. 1997
    ..IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat...
  23. doi The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 OXY, UK
    J Clin Immunol 28:685-96. 2008
    ....
  24. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  25. ncbi Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10
    Song Guo Zheng
    Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 172:5213-21. 2004
    ..We suggest that the long-term effects of adoptively transferred natural-like CD4(+)CD25(+) regulatory cells induced ex vivo are due to their ability to generate new cytokine-producing CD4(+) regulatory T cells in vivo...
  26. pmc Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo
    S Glushakova
    Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Virol 73:3968-74. 1999
    ..Thus, Nef can facilitate HIV-1 replication in human lymphoid tissue ex vivo by increasing the numbers of productively infected cells and by increasing the responsiveness to IL-2 stimulation...
  27. ncbi Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation
    Yuan Pei
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    J Immunol 180:222-9. 2008
    ..In vivo and in vitro data support a model in which CD28 costimulation activates AKT to phosphorylate NF90 at Ser647 and phosphorylation triggers NF90 to relocate to the cytoplasm and stabilize IL-2 mRNA...
  28. pmc HIV-1 Nef increases T cell activation in a stimulus-dependent manner
    J A Schrager
    Laboratory of Molecular Biology, National Institute of Mental Health, 36 Convent Drive, Bethesda, MD 20892 4034, USA
    Proc Natl Acad Sci U S A 96:8167-72. 1999
    ..The capacity of Nef to increase T cell activity may be very important in vivo when Nef is the predominant or the only viral gene product expressed...
  29. ncbi The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation
    Joanne L Attema
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 169:2466-76. 2002
    ....
  30. pmc A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    David A van Heel
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
    Nat Genet 39:827-9. 2007
    ..3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease...
  31. ncbi Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    B Sadlack
    Institute of Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Cell 75:253-61. 1993
    ..The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus...
  32. pmc The Nef protein of HIV-1 associates with rafts and primes T cells for activation
    J K Wang
    Department of Genetics and Microbiology, University of Geneva, CH 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 97:394-9. 2000
    ..Overall, these data suggest that Nef acts at the level of rafts to prime T cells for activation. Likely consequences of this effect are the promotion of HIV-1 replication and the facilitation of virus spread...
  33. ncbi Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
    Xinquan Wang
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305, USA
    Science 310:1159-63. 2005
    ..This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics...
  34. doi The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes
    Francesca Neri
    Laboratory of Immunoinfectivology, Children s Hospital Bambino Gesu, 00165 Rome, Italy
    Virology 410:316-26. 2011
    ..Our data indicate that Nef has a dual role in the modulation of TCR signaling aimed at favoring HIV-1 replication and spread in both quiescent and metabolically active CD4(+) T lymphocytes...
  35. pmc IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
    Wei Liao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Curr Opin Immunol 23:598-604. 2011
    ..In this fashion, IL-2 can prime and potentially maintain Th1 and Th2 differentiation as well as expand such populations of cells, whereas it inhibits Th17 differentiation but also can expand Th17 cells...
  36. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
    ..Cytokine single nucleotide polymorphisms could play a role in the pathophysiology of BD. The results of this study could suggest a tendency towards higher production of IL-2 and lower production of IL-4 in the patients with BD...
  37. ncbi Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    H Schorle
    Institute of Virology and Immunobiology, University of Wurzburg, Germany
    Nature 352:621-4. 1991
    ....
  38. doi Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..We confirmed two known loci and identified four novel ones for shared CD-RA genetic risk. Most of the shared loci further emphasize a role for adaptive and innate immunity in these diseases...
  39. pmc Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells
    Mohamed Oukka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 199:15-24. 2004
    ..KRC), is induced upon T cell receptor signaling in T cells and functions to regulate the expression of the interleukin 2 (IL-2) gene...
  40. ncbi Nuclear export of NF90 is required for interleukin-2 mRNA stabilization
    Jaekyung Shim
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 10:1331-44. 2002
    ..In nonstimulated cells, NF90 is mostly nuclear, but T cell activation results in its accumulation in the cytoplasm. The nuclear export of NF90 is required for IL-2 mRNA stabilization...
  41. ncbi HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line
    S D Schibeci
    Department of Clinical Immunology, Westmead Hospital, NSW, Australia
    AIDS 14:1701-7. 2000
    ..The Nef protein has a major influence on disease pathogenesis in HIV-infected individuals. The objective of the present study was to examine the effects of Nef on T lymphocyte activation and associated signalling events...
  42. ncbi The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
    Y Sotsios
    Department of Pharmacy and Pharmacology, Bath University, Claverton Down, Bath, Avon, United Kingdom
    J Immunol 163:5954-63. 1999
    ..Hence, it appears that ERK1/2 activation is dependent on PI 3-kinase activation, and both biochemical events are involved in the regulation of SDF-1-stimulated chemotaxis...
  43. pmc Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
    E A M Festen
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gut 58:799-804. 2009
    ..type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and psoriasis), while the roles that interleukin 2 (IL2) and IL21 play in the immune response also make them attractive candidates for IBD...
  44. pmc Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus
    Amit K Maiti
    Oklahoma Medical Research Foundation, Oklahoma City, OK73104, USA
    Arthritis Rheum 62:323-9. 2010
    ....
  45. doi Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population
    M Fedetz
    Departmento de Biología Celulare Immunologia, Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    Tissue Antigens 74:244-7. 2009
    ..Additional studies, using much larger sample sizes and analysis of additional polymorphisms in the gene and its flanking region, will be required to ascertain their contributions to MS susceptibility...
  46. doi Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis
    Nina A Daha
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1255-60. 2009
    ....
  47. doi Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease
    Ana Marquez
    Immunology Department, Hospital Clinico San Carlos, Madrid 28040, Spain
    Am J Gastroenterol 104:1968-75. 2009
    ..Therefore, we decide to investigate the association of polymorphisms in the IL-2 axis (IL2, IL2RA, and IL2RB genes) with inflammatory bowel diseases (IBDs)...
  48. pmc Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study
    Vitor Hugo Teixeira
    GenHotel EA3886, Evry University Paris 7 University Medical School, AutoCure European Consortium, Evry Genopole, France
    Arthritis Res Ther 11:R45. 2009
    ..Therefore, our aim was to test this association in populations of European origin by using a family-based approach...
  49. pmc Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA
    S Luria
    Department of Biochemistry, Beckman Center, Stanford University Medical Center, CA 94305
    Proc Natl Acad Sci U S A 88:5326-30. 1991
    ..PHA) or antibodies against CD3 epsilon, T-cell receptor beta chain, or CD2, there is a prompt increase in interleukin 2 (IL-2) mRNA and intracellular calcium and in the IL-2 receptor alpha chain on the cell surface...
  50. ncbi Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation
    C T J Holweg
    Erasmus MC, Department of Internal Medicine, Room Ee 563a, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transpl Immunol 11:121-7. 2003
    ..63). In conclusion, we did not detect an association between the IL-2 T-330G promoter polymorphism and CA repeat polymorphism in the first intron of the IFN-gamma gene and AR or GVD after heart transplantation...
  51. ncbi Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy
    Letizia Scola
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Biogerontology 6:425-9. 2005
    ..All in all our data seem to suggest that reduction of -330G allele frequency might be protective for healthy ageing limiting cell mediated inflammation implied in age associated diseases...
  52. ncbi IL-2 gene C/T polymorphism is associated with prostate cancer
    Hsi Chin Wu
    Department of Urology, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 20:245-9. 2006
    ..388). This study suggests that the IL-2 gene may be associated with susceptibility to prostate cancer in the Taiwan population...
  53. doi Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes
    Kevin S Goudy
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 186:3779-86. 2011
    ..These results demonstrate that inducible IL-2 gene therapy is an effective and safe approach to manipulate Foxp3(+)Treg and suppress T cell-mediated autoimmunity and that under the conditions employed, IL-2 is more potent than TGF-β1...
  54. ncbi Interleukin-2 and interleukin-6 gene promoter polymorphisms, and early failure of dental implants
    Maria Isabela Guimarães Campos
    Department of Morphology, Dental School of Piracicaba, State University of Campinas, Piracicaba, Brazil
    Implant Dent 14:391-6. 2005
    ....
  55. doi Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation
    S J Park
    Organ Transplantation Center, College of Medicine, Inje University, Busan, South Korea
    Transplant Proc 43:2383-7. 2011
    ..738; P = .0295) showed associations with ARE. Our results demonstrate that genetic variants of IL2RB may be associated with the development of AREs and may help predict ARE risk in kidney transplantation patients...
  56. ncbi The IL-2 receptor complex: its structure, function, and target genes
    Y Minami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Annu Rev Immunol 11:245-68. 1993
    ..Another pathway leads to c-myc gene induction by an as yet unknown mechanism. We discuss the complex signalling machinery that links the cell surface receptor to the nuclear events...
  57. ncbi Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients
    D O McDaniel
    Department of Surgery, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4550, USA
    Transpl Immunol 11:107-19. 2003
    ..Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy...
  58. doi A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
    ..Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression...
  59. ncbi Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6
    E D Cox
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Transplantation 72:720-6. 2001
    ..Ethnic origin has been identified as a significant prognostic factor for several immune-mediated diseases and for outcome after allotransplantation. A clear relationship between cytokine polymorphisms and ethnicity has not been shown...
  60. pmc The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development
    Iris Castro
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 187:5170-82. 2011
    ..Our findings are consistent with a model whereby low, intermediate, and high CD122 signaling support T(CM) memory survival, T(EM) programming, and terminal T effector cell differentiation, respectively...
  61. ncbi Interleukin-2 gene polymorphism is associated with renal but not cardiac transplant outcome
    A Morgun
    Division of Immunogenetics, Department of Pediatrics, Sao Paulo, Brazil
    Transplant Proc 35:1344-5. 2003
    ..Further studies are necessary not only to dissect the nature of IL-2 T/T genotype association with kidney rejection, but also to explain why this genotype does not apparently influence cardiac allograft outcome...
  62. pmc Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk
    María L Cavanillas
    Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 18:794-9. 2010
    ..The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation...
  63. ncbi IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, Powst Wlkp 72, Poland
    Transplant Proc 37:2041-3. 2005
    ..The aim of the study was to examine the association between interleukin (IL)-2 -330 and tumor necrosis factor (TNF)-alpha -308 promoter polymorphisms and acute kidney allograft rejection...
  64. ncbi The cytokine gene polymorphisms in patients with chronic kidney graft rejection
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, Powst Wielkopolskich 72, Poland
    Transpl Immunol 14:49-52. 2005
    ..The results of present study suggest that the genetically determined low IL-6 production may be the risk factor of chronic allograft nephropathy development...
  65. doi IL-2 -330 T/G SNP and serum values-potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs)
    Maja Cigrovski Berković
    Department of Endocrinology, Diabetes and Metabolism, University Hospital Sestre Milosrdnice, Vinogradska 29, 10000, Zagreb, Croatia
    J Mol Med (Berl) 88:423-9. 2010
    ..039). Compared to CgA and 5-HIAA, IL-2 was more specific in detecting GEP-NET patients (p < 0.0001 and p < 0.0001, respectively). Our results indicate importance of IL-2 in GEP-NET development and biochemical diagnosis...
  66. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  67. pmc Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes
    M Kryworuchko
    Unité d Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    Clin Exp Immunol 131:422-7. 2003
    ..This Jak/STAT deficiency may contribute to the crippling of CD4 T cell responses to a cytokine central to the immune response by HIV...
  68. pmc Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells
    T M Niederman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Virol 66:6213-9. 1992
    ..Additionally, Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site...
  69. pmc Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation
    Jason F Kreisberg
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Exp Med 203:865-70. 2006
    ....
  70. ncbi Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population
    J Javor
    Department of Immunology, School of Medicine, Comenius University, Saskinova 4, 811 08 Bratislava, Slovakia
    Int J Immunogenet 34:273-80. 2007
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases...
  71. ncbi Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression
    Fuencisla Matesanz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla 11, 18001 Granada, Spain
    J Neuroimmunol 148:212-7. 2004
    ..Our data show an increased IL2 expression among GT and TT genotypes previously associated with susceptibility to MS...
  72. ncbi Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis
    Maria Fedetz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Granada, Spain
    J Rheumatol 30:435-7. 2003
    To investigate the association of 2 single nucleotide polymorphisms (SNP) at positions -384 and 114 in the human interleukin 2 (IL-2) gene with susceptibility to and severity of rheumatoid arthritis (RA).
  73. pmc Amino acid sequence and post-translational modification of human interleukin 2
    R J Robb
    Proc Natl Acad Sci U S A 81:6486-90. 1984
    Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing...
  74. ncbi Unraveling the structure of IL-2
    J F Bazan
    Science 257:410-3. 1992
  75. ncbi The interleukin-2 and interleukin-4 receptors studied by molecular modelling
    P Bamborough
    Oxford Centre for Molecular Science, Physical Chemistry Laboratory, UK
    Structure 2:839-51. 1994
    ..They are therefore of interest as transmembrane signalling proteins, as well as potential pharmaceutical targets...
  76. ncbi In vitro treatment with interleukin-2 normalizes type-1 cytokine production by lymphocytes from elderly
    D Lio
    , Italy
    Immunopharmacol Immunotoxicol 22:195-203. 2000
    ..Present and previous results suggest that rIL-2 completely restores Type 1 responses by overcoming the well known costimulation deficit of aged lymphocytes...
  77. ncbi Investigation of the influence of maternal infection with Wuchereria bancrofti on the humoral and cellular responses of neonates to filarial antigens
    W L Hitch
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann Trop Med Parasitol 91:461-9. 1997
    ..Based on these limited responses to filarial antigens, few neonates display evidence of in-utero sensitization to filarial antigens...
  78. ncbi Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia
    N Muller
    Psychiatric Hospital, Ludwig Maximilian University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 247:308-13. 1997
    ..This suggests that neuroleptic therapy has a differentiated immunomodulatory effect...
  79. ncbi [Spinach powder-induced exogenous allergic alveolitis]
    J Schreiber
    Forschungszentrum Borstel, Medizinische Klinik
    Pneumologie 52:61-5. 1998
    ..24 hours after exposure bronchoalveolar lavage showed an increase of neutrophils. In lung parenchyma mononuclear interstitial infiltrates and an epitheloid cell granuloma were seen...
  80. ncbi Histamine and cytokine therapy
    K Hellstrand
    Department of Virology, , Sweden
    Acta Oncol 37:347-53. 1998
    ..The potential benefit of histamine therapy in melanoma and AML will be evaluated in randomized trials...
  81. ncbi Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 production
    M Colic
    Institute of Medical Research, Military Medical Academy, Belgrade, Yugoslavia
    Immunopharmacol Immunotoxicol 22:163-81. 2000
    ..The effect correlated with upregulation of the Interleukin 2 receptor alpha (IL-2R alpha) expression and the increase in IL-2 production...
  82. ncbi [Serum adenosine deaminase as a parameter for activity in sarcoidosis]
    E Wetzel
    Krankenanstalt, , Akademisches Lehrkrankenhaus,
    Pneumologie 53:323-8. 1999
    ..In comparison to the other parameters, measurement of the serum ADA indicates a greater discrimination between active and inactive disease...
  83. ncbi Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats
    G Sireci
    Institute of General Pathology, University of Palermo, Italy
    Immunopharmacol Immunotoxicol 21:583-98. 1999
    ....
  84. ncbi [Study on cellular immunity in children with respiratory syncytial virus associated acute lower respiratory infection]
    Z Chen
    Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:263-6. 1997
    ..These results suggested that human body had a functional disturbance in cellular immunity when infected with RSV...
  85. ncbi Cytokine pattern secretion by murine spleen cells after inactivated Candida albicans immunization. Effect of cocaine and morphine treatment
    I A Casalinuovo
    Department of Experimental Medicine and Biochemical Sciences, Microbiology, University of Rome Tor Vergata, Italy
    Immunopharmacol Immunotoxicol 22:35-48. 2000
    ..The results showed that non-viable Candida cells of this strain induce a predominant Th0 response. This immune effect is in part impaired only by a subchronic administration of morphine...
  86. ncbi Interleukin 1 and interferon-gamma: cytokines that provide reciprocal regulation of macrophage and T cell function
    R M Schultz
    Department of Immunology Research, Lilly Research Laboratories, Indianapolis, Indiana 46285
    Toxicol Pathol 15:333-7. 1987
    ..induces activation and replication of several subsets of precursor lymphocytes, including cytotoxic T cells, lymphokine-activated killer (LAK) cells, and natural killer (NK) cells, and enhances their cytotoxic activity for tumor ..
  87. ncbi Inducing a cell-mediated immune response against peptides of the Plasmodium vivax circumsporozoite protein
    B E Thomas
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Ann Trop Med Parasitol 95:573-86. 2001
    ..vivax sporozoites...
  88. ncbi Immunotherapy with low-dose subcutaneous interleukin-2 plus beta-interferon as a second-line therapy for metastatic colorectal carcinoma
    S Barni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 79:343-6. 1993
    ..Further studies in patients with less advanced disease are needed to better define the impact of the immune improvement induced by low-dose IL-2 plus beta-IFN on the clinical course of the neoplastic disease...
  89. ncbi Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints
    Y T Konttinen
    Fourth Department of Medicine, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 15:387-90. 1990
    ....
  90. ncbi Re-infection in human schistosomiasis mansoni: a prospective field study 18 months after praziquantel therapy
    K Zwingenberger
    , Berlin
    Ann Trop Med Parasitol 84:457-65. 1990
    ..Both soluble CD8 antigen and interleukin 2 receptor in patients' sera were significantly elevated throughout the study period...
  91. ncbi Cellular reaction to the Vascugraft polyesterurethane vascular prosthesis: in vivo studies in rats
    B Huang
    , Department of Surgery, , , Canada
    Biomaterials 13:209-16. 1992
    ..The Mitrathane prosthesis exhibited a moderate inflammatory response, characterized by a high level of activation on fibroblasts compared to other grafts...
  92. ncbi Interleukin-2 receptor levels in non-Hodgkin's lymphoma. Correlation to histological degree of malignancy and presence of constitutional symptoms
    J M Tangen
    Department of Oncology, , Oslo, Norway
    Acta Oncol 29:581-3. 1990
    ..All three parameters should therefore be taken into account when the clinical significance of Il-2R levels is evaluated...
  93. ncbi Suppressive and enhancing effect of T-2 toxin on murine lymphocyte activation and interleukin 2 production
    P S Holt
    U.S. Department of Agriculture, Veterinary Toxicology and Entomology Research Laboratory, College Station, Texas 77841
    Immunopharmacol Immunotoxicol 10:365-85. 1988
    ..shown previously to exert potent immunosuppressive effects, was examined for its effects on activation and interleukin 2 (IL 2) production by murine and rat splenocytes...
  94. ncbi Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol
    M Maes
    CRC-MH, Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium
    Eur Arch Psychiatry Clin Neurosci 245:172-8. 1995
    ..There were also significant positive correlations between plasma prolactin and sIL-2R concentrations in major depressed subjects and in the combined groups of normal and major depressed subjects...
  95. ncbi Sodium aurothiomalate inhibits T cell responses to interleukin-2
    M Harth
    Rheumatic Diseases Unit, University Hospital, University of Western Ontario, London, Canada
    Immunopharmacol Immunotoxicol 10:141-56. 1988
    ..These effects of SATM may explain some of the conflicting data in the literature on T cell responses to IL-2 in rheumatoid arthritis (RA), and suggest a possible mechanism of action for the drug in the treatment of RA...
  96. ncbi Modulation of the interleukin 2 receptor by maternal and cord blood serum
    Y E Vanderbeeken
    Department of Immunology, Hospital St-Pierre, Brussels, Belgium
    Immunopharmacol Immunotoxicol 12:211-36. 1990
    ..However, at physiological concentrations of IgG, the Interleukin 2 receptor downregulation becomes irreversible.
  97. ncbi Subcutaneous low-dose interleukin-2 plus alpha interferon in advanced malignant melanoma
    F de Braud
    Divisione di Oncologia Medica B, Istituto Nazionale per la Cura e lo Studio dei Tumori, Milano, Italy
    Tumori 79:187-90. 1993
    ..The good patient compliance makes this schedule eligible to evaluate whether IL-2 plus rIFN-alpha can enhance the results of chemotherapy in this disease...
  98. ncbi Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins
    M H Rapaport
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla 92093
    Eur Arch Psychiatry Clin Neurosci 243:7-10. 1993
    ..08) showed trends towards higher serum SIL-2R levels than their respective control groups. These data contribute to the growing body of evidence that immune activation is associated with some forms of schizophrenia...
  99. ncbi Nicotine enhances interleukin production of rat splenic T lymphocytes
    T M Petro
    University of Nebraska Medical Center, College of Dentistry, Dept. of Oral Biology, Lincoln 68583-0740
    Immunopharmacol Immunotoxicol 14:463-75. 1992
    ..A (ConA) or phytohemagglutinin (PHA), and the ability of mitogen stimulated splenic T lymphocytes to produce interleukin 2 (IL2) were determined...
  100. ncbi Circulating soluble IL-2 receptor levels are low in patients with hypothyroid autoimmune thyroiditis
    A Loviselli
    Institute of Internal Medicine, University of Cagliari, Italy
    Horm Metab Res 26:548-51. 1994
    ..In our report we studied circulating soluble interleukin 2 receptors in 22 patients with hypothyroid autoimmune thyroiditis before L-thyroxine treatment and when the ..

Research Grants69

  1. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..The BMT/CTN including our consortium will be the only clinical cooperative group to accomplish this goal. ..
  2. Role of MEK1 in T cell function in asthma
    Rafeul Alam; Fiscal Year: 2013
    ..The proposal is important because it addresses the mechanism of persistence of airway inflammation in asthma. The results of this study will lead to the development of novel therapeutic modalities for asthma. ..
  3. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN-g)...
  4. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN?)...
  5. RENAL CELL CARCINOMA--ADOPTIVE IMMUNOTHERAPY
    KURT STENZEL; Fiscal Year: 1990
    ..Methodology and feasibility for on-line activation of lymphoid cells for adoptive immunotherapy will be investigated using a murine tumor model...
  6. Arginine Availability, Modulated by MDSC, Regulates T Cell Function in Cancer
    Augusto C Ochoa; Fiscal Year: 2013
    ..Cancer vaccines and cytokines can be an important therapeutic approach for patients whose tumors have failed standard forms of treatment. ..
  7. MELANOMA VACCINE FOR HELPER T CELLS COMBINED WITH TARGETED OR IMMUNE THERAPIES
    CRAIG LEE SLINGLUFF; Fiscal Year: 2013
    ....
  8. IL-2 scintigraphy as a guide to cancer immunotherapy
    SVETOMIR NENAD MARKOVIC; Fiscal Year: 2013
    ....
  9. TGFbeta Blockade in MART TCR-Engineered T Cell Melanoma Immunotherapy in Man
    Richard C Koya; Fiscal Year: 2013
    ..This present proposal will directly address this problem with the goal of achieving sustained clinical responses. ..
  10. Enhancing renal cell carcinoma response to IL-2 with the HDAC inhibitor SNDX-275
    Roberto Pili; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): High dose interleukin 2 (IL-2) is an approved regimen for metastatic renal cell carcinoma (RCC). Unfortunately, the response rate is modest and only few patients achieve durable remission...
  11. The Role of KIR and FcR Genotype in the Efficacy of mAb and IL2 Immunotherapy
    Paul M Sondel; Fiscal Year: 2013
    ....
  12. Expression profiling of renal cell carcinoma utilizing tissue from CALGB 90206
    Hyung L Kim; Fiscal Year: 2013
    ..abstract_text> ..
  13. Targeting Novel T Cell Antigens on Renal Cell Carcinoma
    Scott S Tykodi; Fiscal Year: 2010
    ..Identifying the key components of the tumor-specific immune response that occurs after such transplants may foster the development of novel and more effective immune therapies for this cancer. ..
  14. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..We propose to study the complex interplay of environmental, immunological and genetic factors to discover molecular signatures with a potential to advance clinical diagnosis and therapy at or before the onset of T1D. ..
  15. Bridging Pediatric and Adult Biomarkers of Graft-Versus-Host-Disease
    Jamie L Renbarger; Fiscal Year: 2013
    ..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
  16. MOLECULAR ENGINEERING OF IL-2 FOR THE TREATMENT AND PREVENTION OF TYPE I DIABETES
    AARON MICHAEL RING; Fiscal Year: 2013
    ..Thus, through these multidisciplinary and translational studies, we will advance new candidate T1D therapies for clinical development. ! ..
  17. Development of Intestinal Immune Regulation in Human Infants
    JOERN HENDRIK WEITKAMP; Fiscal Year: 2013
    ..This proposal develops novel translational approaches to identify cellular and molecular targets for reducing the pathologic host immune response in NEC and to detect infants at highest risk of this devastating disease. ..
  18. Regulatory T Cell-Deficient Mouse Model Rapidly Develops Sjogren's Syndrome
    Shyr Te Ju; Fiscal Year: 2010
    ..This study should identify new and useful models for Sjogren's syndrome research. It should identify new mechanism(s) for the pathogenesis of the disease and provide potential treatment of the disease. ..
  19. EFFECTS OF PHORBOL ESTERS ON LYMPHOCYTE STIMULATION
    Andrea Mastro; Fiscal Year: 1991
    ..Mitogenic lectins along with macro-phages induce production of interleukin 1 (IL1), interleukin 2 (IL2), and their receptors which interact to cause proliferation. These interactions are not well understood...
  20. The IL-2 receptor in T regulatory cell development
    Thomas R Malek; Fiscal Year: 2012
    ..abstract_text> ..
  21. IMMUNOREGULATION OF ERYTHROPOIESIS
    Lee Levitt; Fiscal Year: 1992
    ..assess how triggering CD2 with a defined ligand, or with CD2-activating monoclonal antibodies, modulates T cell growth factor production and erythroid regulation...
  22. IL2 RECEPTORS--ANALYSIS OF ASSEMBLY AND SIGNALING
    Warner Greene; Fiscal Year: 1999
    ....
  23. DESIGN OF MULTIMERIC INTERLEUKIN-2 RECEPTOR ECTODOMAINS
    Thomas Ciardelli; Fiscal Year: 2000
    ..4. To obtain detailed structure-activity data on these complexes by co-crystallizing them with IL-2 and determining their X-ray structures to high resolution. ..
  24. NCI CLINICAL INVESTIGATOR AWARD
    David Peace; Fiscal Year: 1991
    The lymphokine Interleukin 2 (IL2) was first recognized for its ability to induce the proliferation of T cells activated by antigen or mitogen to express IL2 receptors...
  25. REGULATION OF C-FOS EXPRESSION DURING T CELL ACTIVATION
    Stephen Benedict; Fiscal Year: 1992
    ..Stimulation of the T cell antigen receptor (TCR) with appropriately presented antigen induces synthesis of the interleukin 2 (IL2) receptor (IL2R), and of IL2. Stimulation of the IL2R with IL2 causes the T cells to proliferate...
  26. REGULATORY MECHANISMS IN HUMAN NATURAL CYTOTOXICITY
    Takashi Makinodan; Fiscal Year: 1990
    ..Methodologies involving cell isolation and mixture techniques, use of monoclonal and polyclonal reagents, receptor-ligand binding studies, and analyses of protein and mRNA synthesis are proposed...
  27. SAR OF INTERLEUKIN 2 AND IL-2 RELATED PEPTIDES
    Thomas Ciardelli; Fiscal Year: 1993
    ....
  28. ROLE OF IL2 RECEPTOR POSITIVE CELLS IN TRANSPLANTATION
    Nicholas Tilney; Fiscal Year: 1991
    ..The role of activated leukocytes developing receptors for interleukin 2 (IL2R+ cells) in rejection will be emphasized, and their modulation by various IL2R targeted therapies ..
  29. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  30. Antibody cytokine fusion proteins against Cryptococcus neoformans
    DAVID OWEN BEENHOUWER; Fiscal Year: 2012
    ..The proposed studies have relevance beyond cryptococcal infection, since a significant long-term objective is to design antibody-cytokine fusion proteins for use in other types of infections. ..
  31. Pathophysiology of Adult T-cell Leukemia/Lymphoma
    UTPAL P DAVE; Fiscal Year: 2013
    ..Our aims are well-timed and can have a significant impact on a disease that is universally fatal upon diagnosis and advance our understanding of JAK3's role in T-cell neoplasia. ..
  32. Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    Manuel L Penichet; Fiscal Year: 2013
    ..A novel nanobiopolymer-based therapy against HER2/neu expressing cancer cells with sufficient capacity to inhibit angiogenesis and orchestrate an anti-tumor immune response should make a significant clinical impact. ..
  33. New Strategies to Prevent Death from Influenza
    Kendall A Smith; Fiscal Year: 2010
    ..If successful, this research effort will provide the foundation for the development of a universal approach to the prevention and treatment of one of the world's most dangerous microbes, one that kills hundreds of thousands yearly. ..
  34. The Role of EOS in Regulatory T-cell Biology.
    Drew M Pardoll; Fiscal Year: 2013
    ....
  35. VEGI-192 As An Anticancer Therapeutic Agent
    LUYUAN LI; Fiscal Year: 2010
    ....
  36. Mechanisms of invariant NKT cell-mediated in vivo anti-tumor responses
    Hamid Bassiri; Fiscal Year: 2013
    ..abstract_text> ..
  37. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    ..These investigations open new avenues to enhance antiviral immune response in the setting of chronic ethanol consumption by improving DC function. ..
  38. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert E Kaminski; Fiscal Year: 2013
    ....
  39. Interferon actions and autoimmune disorders
    Michael David; Fiscal Year: 2010
    ..b>Interleukin 2 (IL-2) is powerful mitogen for T cells, and its production is a hallmark of T cell activation...
  40. Type 1 Diabetes Mouse Resource (T1DR)
    David V Serreze; Fiscal Year: 2012
    ..The mission of the T1DR is to import, re-derive to a high-level health status, curate, genotypically and phenotypically validate, cryopreserve, and distribute mouse stocks of value to the T1D research community. ..
  41. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  42. Genetic and Functional Analysis of IL-2 Deficiency in Lupus-Prone Mice
    Zhiwei Xu; Fiscal Year: 2013
    ..Our design of this project aims at identifying the gene responsible for the IL-2 deficiency and elucidating its roles in lupus pathogenesis, which will contribute to discovering a new therapeutic target for lupus treatment. ..
  43. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2012
    ..These studies will shed light on the mechanisms of immune regulation and tolerance, and may help to optimize protocols for the therapeutic uses of IL-2 and its antagonists. ..
  44. Efficacy and safety of novel CD80 IL15 IL15Ra expressing autologous AML vaccines
    KARIN L GAENSLER; Fiscal Year: 2013
    ..Studies will directly inform the design of a Phase 1 clinical AML vaccine trial at UCSF for patients >60, ineligible for HSCT. ..
  45. MOLECULAR AND CELLULAR ANALYSIS OF G PROTEIN FUNCTION
    Catherine H Berlot; Fiscal Year: 2013
    ..the small molecule, 1 gallein, leads to increased T cell receptor (TCR)-stimulated production of the cytokine, interleukin 2 (IL-2) in CD4+ T cells...
  46. CEA TARGETED IMMUNOTHERAPEUTICS
    Andrew A Raubitschek; Fiscal Year: 2012
    ..This aim is the culmination of the translational research process, investigating our best approaches to treat a significant disease in humans, metastatic colorectal cancer. ..
  47. Phase 1 Study of Interleukin-2 in Wiskott-Aldrich Syndrome
    Soma Jyonouchi; Fiscal Year: 2013
    ....
  48. Bifunctional T cell receptor based immunotherapeutics
    Hing C Wong; Fiscal Year: 2011
    ..This may lead to a safe and effective approach to treat patients with refractory, metastatic cancer. ..
  49. CANCER THERAPY WITH ACTIVATED NATURAL KILLER CELLS
    Ronald Herberman; Fiscal Year: 2000
    ..efficacy of lymphokine-activated killer (LAK) cells when administered in combination with high dose interleukin 2 (IL2), and the demonstration that most LAK activity is attributable to IL2-activated NK cells, the therapeutic ..
  50. Gene Transcription in SLE
    George C Tsokos; Fiscal Year: 2012
    ..SLE T cells produced reduced amounts of interleukin 2 (IL-2) which contributes to the increased rate of infections, decreased generation of cytotoxic and regulatory ..
  51. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  52. Signal transduction and gene induction in lymphocytes
    Anjana Rao; Fiscal Year: 2013
    ....
  53. Genetic Basis for susceptibility to EAE
    Vijay K Kuchroo; Fiscal Year: 2011
    ..abstract_text> ..
  54. Manipulation of Immune Responsiveness after Hematopoietic Cell Transplantation
    ROBERT JON SOIFFER; Fiscal Year: 2013
    ..PROJECT/PERFORMANGE SITE(S) (if additional space is needed, use Project/Perfonnance Site Fonnat Page) ..
  55. Role of Tat and SIRT1 in the T-cell Hyperactivation Syndrome Induced by HIV-1
    MELANIE MARIA OTT; Fiscal Year: 2013
    ..These studies are directly relevant to HIV/AIDS and may contribute to the development of novel antiviral drugs that will address public need. ..
  56. Targeting CaMK4 in SLE
    George C Tsokos; Fiscal Year: 2013
    ..The significance of the proposed work lies with the fact that it presents a novel target for the treatment of SLE and that it develops a targeted delivery of a small drug. ..
  57. Naive T cell homeostasis: Treg selection and survival
    Christophe O Benoist; Fiscal Year: 2013
    ..The results should lead to a better understanding of this population that is key to immune and autoimmune regulation. ..
  58. Sphingosine Phosphate Role in Inflammation
    Lina Obeid; Fiscal Year: 2009
    ..These studies will enable us to gain important insight into the role of this pathway in inflammatory responses and may also provide novel therapeutic approaches to inflammation. ..
  59. Gene Transcription in SLE
    George C Tsokos; Fiscal Year: 2013
    ....
  60. Structure Function Studies of the Spindle-Pole Body in Saccharomyces Cerevisiae
    Ivan Rayment; Fiscal Year: 2012
    ..The fundamental knowledge gained here will be of great value in understanding the molecular basis of disease. ..
  61. Effects of diacylglycerol kinase zeta deficiency on CD8+ T cell function
    Matthew J Riese; Fiscal Year: 2013
    ..We have found a new target for treating cancer, dgk-zeta, which awakens the immune system in mice, preventing cancer growth. This grant will figure out exactly how dgk-zeta works in a type of T cell known to attack cancer cells. ..
  62. Enhancing Treg Immune Reconstitution After Stem Cell Transplant
    CATHERINE MARY BOLLARD; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We propose using ultra low dose Interleukin 2 (ULD-IL2) to reduce the risk of Graft versus host disease after allogeneic hematopoietic stem cell transplantation (Allo SCT) by increasing levels of ..
  63. Phosphatases in Human Lupus
    George C Tsokos; Fiscal Year: 2013
    ....
  64. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..Ultimately, this approach may provide a safer and more effective treatment for patients with cancer than the currently approved immunotherapies. ..
  65. The Cytoskeleton, Rafts and the Interleukin-2 Receptor
    Jens Goebel; Fiscal Year: 2005
    ..abstract_text> ..
  66. MONOKINES IN CONTROL OF HYPOTHALAMIC-PUTUITARY AXIS
    Samuel McCann; Fiscal Year: 1991
    ..We will determine effects of interleukin 1 and interleukin 2 in altering hypothalamic pituitary function and determine whether the effects are mediated directly on the ..
  67. Phase I Study of ALT-801 in Metastatic Melanoma/Kidney Cancer Patients
    Mayer Fishman; Fiscal Year: 2009
    ....
  68. CANCER CHEMOTHERAPY AND IMMUNOLOGIC EFFECTS
    Enrico Mihich; Fiscal Year: 2001
    As shown in this laboratory, combinations of doxorubicin plus interleukin 2 (DOX + IL2) exert curative effects in C57BL/6 mice implanted with 10-5 EL4 lymphoma cells, a relatively nonimmunogenic syngeneic tumor/mouse model where 10 EL4 ..
  69. Naive T cell homeostasis: Treg selection and survival
    Christophe Benoist; Fiscal Year: 2009
    ..The results should lead to a better understanding of this population that is key to immune and autoimmune regulation. ..