interleukin 2

Summary

Gene Symbol: interleukin 2
Description: interleukin 2
Alias: IL-2, TCGF, lymphokine, T cell growth factor, aldesleukin, interleukin-2, involved in regulation of T-cell clonal expansion
Species: human

Top Publications

  1. doi Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    S Adamovic
    Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Genes Immun 9:364-7. 2008
  2. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
  3. ncbi Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
    Xinquan Wang
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305, USA
    Science 310:1159-63. 2005
  4. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
  5. pmc Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo
    Tao Zou
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 189:28-32. 2012
  6. ncbi Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    H Schorle
    Institute of Virology and Immunobiology, University of Wurzburg, Germany
    Nature 352:621-4. 1991
  7. pmc Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
    Deborah J Stauber
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2788-93. 2006
  8. pmc The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development
    Iris Castro
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 187:5170-82. 2011
  9. ncbi Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    B Sadlack
    Institute of Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Cell 75:253-61. 1993
  10. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008

Research Grants

  1. DCTD Biopharmaceutical Development - Type 1 Diabetes RAID projects
    LARRY ARTHUR; Fiscal Year: 2009
  2. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2009
  3. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2010
  4. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2012
  5. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2011
  6. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2013
  7. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
  8. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
  9. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
  10. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010

Detail Information

Publications262 found, 100 shown here

  1. doi Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    S Adamovic
    Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Goteborg, Sweden
    Genes Immun 9:364-7. 2008
    ..001 and 0.002, respectively). However, we found no association with the FcgammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region...
  2. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  3. ncbi Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
    Xinquan Wang
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305, USA
    Science 310:1159-63. 2005
    ..This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics...
  4. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
    ..Cytokine single nucleotide polymorphisms could play a role in the pathophysiology of BD. The results of this study could suggest a tendency towards higher production of IL-2 and lower production of IL-4 in the patients with BD...
  5. pmc Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo
    Tao Zou
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 189:28-32. 2012
    ..These findings also have therapeutic implications, as TCR signaling by Tregs may not be required when using IL-2 to increase Treg numbers for treatment of inflammatory disorders...
  6. ncbi Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    H Schorle
    Institute of Virology and Immunobiology, University of Wurzburg, Germany
    Nature 352:621-4. 1991
    ....
  7. pmc Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
    Deborah J Stauber
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2788-93. 2006
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes...
  8. pmc The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development
    Iris Castro
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 187:5170-82. 2011
    ..Our findings are consistent with a model whereby low, intermediate, and high CD122 signaling support T(CM) memory survival, T(EM) programming, and terminal T effector cell differentiation, respectively...
  9. ncbi Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    B Sadlack
    Institute of Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Cell 75:253-61. 1993
    ..The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus...
  10. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008
    ..Thus, there are intrinsic signaling differences between IL-2 and IL-15 that can be attributed to differences in activation of the PI3K pathway...
  11. ncbi Shock waves increase T-cell proliferation or IL-2 expression by activating p38 MAP kinase
    Tie Cheng Yu
    Department of Orthopedics, The First Teaching Hospital of Jilin University, Changchun 130021, China
    Acta Biochim Biophys Sin (Shanghai) 36:741-8. 2004
    ..We concluded that the p38 MAPK activation played a key role in the regulation of T cells function by the LDSWs...
  12. ncbi Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation
    S J Park
    Organ Transplantation Center, College of Medicine, Inje University, Busan, South Korea
    Transplant Proc 43:2383-7. 2011
    ..738; P = .0295) showed associations with ARE. Our results demonstrate that genetic variants of IL2RB may be associated with the development of AREs and may help predict ARE risk in kidney transplantation patients...
  13. ncbi Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation
    Yuan Pei
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    J Immunol 180:222-9. 2008
    ..In vivo and in vitro data support a model in which CD28 costimulation activates AKT to phosphorylate NF90 at Ser647 and phosphorylation triggers NF90 to relocate to the cytoplasm and stabilize IL-2 mRNA...
  14. pmc Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor
    S M Zurawski
    DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304 1104
    EMBO J 12:5113-9. 1993
    ..The relative spatial locations of these three surfaces are different from the two receptor binding sites known for the structurally related human growth hormone and the significance of this observation is discussed...
  15. ncbi Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma
    Yao Yuan Hsieh
    Department of Obstetrics and Gynecology, National Chiao Tung University, Hsinchu, Taiwan
    Fertil Steril 87:886-95. 2007
    ..e., interleukin (IL)-1, IL-2, IL-4, IL-8, IL-12, and IL-18, which are all immunomodulatory cytokines that play important roles in host immune responses against cancers...
  16. ncbi Genetic variants in interleukin-2 and risk of lymphoma among children in Korea
    Nan Song
    Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea
    Asian Pac J Cancer Prev 13:621-3. 2012
    ..TT=3.43 (1.29-9.11), P(trend)=0.002, minP=0.005). These findings suggest that common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma...
  17. ncbi Allelic expression and interleukin-2 polymorphisms in multiple sclerosis
    F Matesanz
    Department of Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla 11, 18001, Granada, Spain
    J Neuroimmunol 119:101-5. 2001
    ..These data indicate for the first time the relevance of the il-2 gene locus in human MS and its possible involvement in other autoimmune diseases...
  18. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  19. ncbi Allelic selection of human IL-2 gene
    F Matesanz
    Departamento de Biología Celular e Inmunología, Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Eur J Immunol 30:3516-21. 2000
    ..These findings may be used as a suitable marker for monitoring the IL-2 allelic contribution to effector activities and in immune responses against different infections or in pathological situations...
  20. doi G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan
    Ying Ju Lin
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Clin Immunol 129:36-9. 2008
    ..01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE...
  21. pmc Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk
    María L Cavanillas
    Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Hum Genet 18:794-9. 2010
    ..The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation...
  22. ncbi Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10
    Song Guo Zheng
    Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 172:5213-21. 2004
    ..We suggest that the long-term effects of adoptively transferred natural-like CD4(+)CD25(+) regulatory cells induced ex vivo are due to their ability to generate new cytokine-producing CD4(+) regulatory T cells in vivo...
  23. ncbi Structure and expression of a cloned cDNA for human interleukin-2
    T Taniguchi
    Nature 302:305-10. 1983
    ..A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells...
  24. pmc Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states
    Urban Sester
    Department of Internal Medicine IV, Saarland University, Homburg, Germany
    PLoS ONE 6:e17813. 2011
    ..In conclusion, a frequency lower than 56% IFN-γ/IL-2 dual positive PPD-specific circulating CD4 T-cells is strongly indicative of active TB...
  25. pmc Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
    E A M Festen
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gut 58:799-804. 2009
    ..type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and psoriasis), while the roles that interleukin 2 (IL2) and IL21 play in the immune response also make them attractive candidates for IBD...
  26. ncbi The IL-2 receptor complex: its structure, function, and target genes
    Y Minami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Annu Rev Immunol 11:245-68. 1993
    ..Another pathway leads to c-myc gene induction by an as yet unknown mechanism. We discuss the complex signalling machinery that links the cell surface receptor to the nuclear events...
  27. ncbi Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease
    Rama Devi Mittal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India
    Immunogenetics 59:159-65. 2007
    ..Further, combined analysis implicated a higher risk in ESRD patients with low IL-4 and high IL-6 producing genotypes. This study provided the basis for defined anti-inflammatory approaches to limit renal disease progression...
  28. ncbi Nuclear export of NF90 is required for interleukin-2 mRNA stabilization
    Jaekyung Shim
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 10:1331-44. 2002
    ..In nonstimulated cells, NF90 is mostly nuclear, but T cell activation results in its accumulation in the cytoplasm. The nuclear export of NF90 is required for IL-2 mRNA stabilization...
  29. ncbi HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line
    S D Schibeci
    Department of Clinical Immunology, Westmead Hospital, NSW, Australia
    AIDS 14:1701-7. 2000
    ..The Nef protein has a major influence on disease pathogenesis in HIV-infected individuals. The objective of the present study was to examine the effects of Nef on T lymphocyte activation and associated signalling events...
  30. ncbi Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population
    J Javor
    Department of Immunology, School of Medicine, Comenius University, Saskinova 4, 811 08 Bratislava, Slovakia
    Int J Immunogenet 34:273-80. 2007
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases...
  31. ncbi The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
    Y Sotsios
    Department of Pharmacy and Pharmacology, Bath University, Claverton Down, Bath, Avon, United Kingdom
    J Immunol 163:5954-63. 1999
    ..Hence, it appears that ERK1/2 activation is dependent on PI 3-kinase activation, and both biochemical events are involved in the regulation of SDF-1-stimulated chemotaxis...
  32. pmc Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus
    Amit K Maiti
    Oklahoma Medical Research Foundation, Oklahoma City, OK73104, USA
    Arthritis Rheum 62:323-9. 2010
    ....
  33. ncbi Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..We confirmed two known loci and identified four novel ones for shared CD-RA genetic risk. Most of the shared loci further emphasize a role for adaptive and innate immunity in these diseases...
  34. pmc Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells
    Mohamed Oukka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 199:15-24. 2004
    ..KRC), is induced upon T cell receptor signaling in T cells and functions to regulate the expression of the interleukin 2 (IL-2) gene...
  35. ncbi Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway
    M Ott
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Science 275:1481-5. 1997
    ..IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat...
  36. doi Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis
    Nina A Daha
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1255-60. 2009
    ....
  37. pmc Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study
    Vitor Hugo Teixeira
    GenHotel EA3886, Evry University Paris 7 University Medical School, AutoCure European Consortium, Evry Genopole, France
    Arthritis Res Ther 11:R45. 2009
    ..Therefore, our aim was to test this association in populations of European origin by using a family-based approach...
  38. doi Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease
    Ana Marquez
    Immunology Department, Hospital Clinico San Carlos, Madrid 28040, Spain
    Am J Gastroenterol 104:1968-75. 2009
    ..Therefore, we decide to investigate the association of polymorphisms in the IL-2 axis (IL2, IL2RA, and IL2RB genes) with inflammatory bowel diseases (IBDs)...
  39. doi Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population
    M Fedetz
    Departmento de Biología Celulare Immunologia, Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    Tissue Antigens 74:244-7. 2009
    ..Additional studies, using much larger sample sizes and analysis of additional polymorphisms in the gene and its flanking region, will be required to ascertain their contributions to MS susceptibility...
  40. ncbi Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients
    D O McDaniel
    Department of Surgery, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4550, USA
    Transpl Immunol 11:107-19. 2003
    ..Identification of peripheral markers diagnostic of rejection could allow advance anticipation of clinical outcome, and might reduce the need for tissue biopsy...
  41. ncbi Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy
    Letizia Scola
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Biogerontology 6:425-9. 2005
    ..All in all our data seem to suggest that reduction of -330G allele frequency might be protective for healthy ageing limiting cell mediated inflammation implied in age associated diseases...
  42. ncbi Interleukin-2 and interleukin-6 gene promoter polymorphisms, and early failure of dental implants
    Maria Isabela Guimarães Campos
    Department of Morphology, Dental School of Piracicaba, State University of Campinas, Piracicaba, Brazil
    Implant Dent 14:391-6. 2005
    ....
  43. ncbi The cytokine gene polymorphisms in patients with chronic kidney graft rejection
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, Powst Wielkopolskich 72, Poland
    Transpl Immunol 14:49-52. 2005
    ..The results of present study suggest that the genetically determined low IL-6 production may be the risk factor of chronic allograft nephropathy development...
  44. ncbi IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection
    A Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, Powst Wlkp 72, Poland
    Transplant Proc 37:2041-3. 2005
    ..The aim of the study was to examine the association between interleukin (IL)-2 -330 and tumor necrosis factor (TNF)-alpha -308 promoter polymorphisms and acute kidney allograft rejection...
  45. ncbi IL-2 gene C/T polymorphism is associated with prostate cancer
    Hsi Chin Wu
    Department of Urology, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 20:245-9. 2006
    ..388). This study suggests that the IL-2 gene may be associated with susceptibility to prostate cancer in the Taiwan population...
  46. ncbi Interleukin-2 gene polymorphism is associated with renal but not cardiac transplant outcome
    A Morgun
    Division of Immunogenetics, Department of Pediatrics, Sao Paulo, Brazil
    Transplant Proc 35:1344-5. 2003
    ..Further studies are necessary not only to dissect the nature of IL-2 T/T genotype association with kidney rejection, but also to explain why this genotype does not apparently influence cardiac allograft outcome...
  47. ncbi Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation
    C T J Holweg
    Erasmus MC, Department of Internal Medicine, Room Ee 563a, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transpl Immunol 11:121-7. 2003
    ..63). In conclusion, we did not detect an association between the IL-2 T-330G promoter polymorphism and CA repeat polymorphism in the first intron of the IFN-gamma gene and AR or GVD after heart transplantation...
  48. ncbi Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6
    E D Cox
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Transplantation 72:720-6. 2001
    ..Ethnic origin has been identified as a significant prognostic factor for several immune-mediated diseases and for outcome after allotransplantation. A clear relationship between cytokine polymorphisms and ethnicity has not been shown...
  49. ncbi Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression
    Fuencisla Matesanz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, C Ventanilla 11, 18001 Granada, Spain
    J Neuroimmunol 148:212-7. 2004
    ..Our data show an increased IL2 expression among GT and TT genotypes previously associated with susceptibility to MS...
  50. pmc A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    David A van Heel
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
    Nat Genet 39:827-9. 2007
    ..3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease...
  51. ncbi The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation
    Joanne L Attema
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 169:2466-76. 2002
    ....
  52. ncbi Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis
    Maria Fedetz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Granada, Spain
    J Rheumatol 30:435-7. 2003
    To investigate the association of 2 single nucleotide polymorphisms (SNP) at positions -384 and 114 in the human interleukin 2 (IL-2) gene with susceptibility to and severity of rheumatoid arthritis (RA).
  53. ncbi Unraveling the structure of IL-2
    J F Bazan
    Science 257:410-3. 1992
  54. ncbi The interleukin-2 and interleukin-4 receptors studied by molecular modelling
    P Bamborough
    Oxford Centre for Molecular Science, Physical Chemistry Laboratory, UK
    Structure 2:839-51. 1994
    ..They are therefore of interest as transmembrane signalling proteins, as well as potential pharmaceutical targets...
  55. pmc Amino acid sequence and post-translational modification of human interleukin 2
    R J Robb
    Proc Natl Acad Sci U S A 81:6486-90. 1984
    Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing...
  56. ncbi Characterization of the pulmonary lesions induced in rats by human recombinant interleukin-2
    J Zhang
    Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1518, USA
    Toxicol Pathol 23:653-66. 1995
    ..to endothelial cells in capillaries and venules, marked interstitial infiltration by cytotoxic T lymphocytes, lymphokine-activated killer (LAK) cells, macrophages, and dendritic cells (as demonstrated by cell counting in preparations ..
  57. ncbi Investigations of cytokine production in whole blood cultures of paranoid and residual schizophrenic patients
    I Wilke
    Institute of Immunology and Transfusion Medicine, , Germany
    Eur Arch Psychiatry Clin Neurosci 246:279-84. 1996
    ..In summary, our data reinforce the possibility of immune dysfunction in schizophrenia and point to the possible relevance of disease subgroups in this respect...
  58. ncbi Halothane inhibits T cell proliferation and interleukin-2 receptor expression in rats
    J G Hamra
    Department of Anesthesiology, University of California, San Diego, LaJolla 92093-0818, USA
    Immunopharmacol Immunotoxicol 18:323-36. 1996
    ..These results suggest that halothane suppresses rat T cell function, perhaps through suppression of IL-2 receptor expression...
  59. ncbi Serum levels of interleukins 2, 6 and 8, soluble interleukin-2 receptor and intercellular adhesion molecule-1 during treatment with interleukin-2 plus interferon-alfa
    M S Vuoristo
    Department of Oncology, Tampere University Hospital, Finland
    Immunopharmacol Immunotoxicol 18:337-54. 1996
    ..Thus, no definite conclusions could be drawn. However, it seems worthwhile to measure IL-2, sIL-2R and sICAM-1 during immunotherapy; their prognostic value should be further evaluated in a larger patient population...
  60. ncbi Effects of cytokines on oxygen radical production by peripheral blood monocytes and alveolar macrophages in patients with lung cancer
    Y Tohda
    Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan
    Tumori 82:382-5. 1996
    ..The results suggest that stimulation of macrophages by interleukin-2, tumor necrosis factor-alpha or interferon-gamma can exert an antitumor action in patients with lung cancer...
  61. ncbi Potentiation of inhaled staphylococcal enterotoxin B-induced toxicity by lipopolysaccharide in mice
    R D LeClaire
    Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702 5011, USA
    Toxicol Pathol 24:619-26. 1996
    ..Temporal responses of interleukin 1 alpha, tumor necrosis factor alpha, interleukin 2, and interferon-gamma evoked by inhaled SEB were enhanced by LPS...
  62. ncbi Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 production
    M Colic
    Institute of Medical Research, Military Medical Academy, Belgrade, Yugoslavia
    Immunopharmacol Immunotoxicol 22:163-81. 2000
    ..The effect correlated with upregulation of the Interleukin 2 receptor alpha (IL-2R alpha) expression and the increase in IL-2 production...
  63. ncbi Investigation of the influence of maternal infection with Wuchereria bancrofti on the humoral and cellular responses of neonates to filarial antigens
    W L Hitch
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann Trop Med Parasitol 91:461-9. 1997
    ..Based on these limited responses to filarial antigens, few neonates display evidence of in-utero sensitization to filarial antigens...
  64. ncbi In vitro treatment with interleukin-2 normalizes type-1 cytokine production by lymphocytes from elderly
    D Lio
    , Italy
    Immunopharmacol Immunotoxicol 22:195-203. 2000
    ..Present and previous results suggest that rIL-2 completely restores Type 1 responses by overcoming the well known costimulation deficit of aged lymphocytes...
  65. ncbi Cytokine pattern secretion by murine spleen cells after inactivated Candida albicans immunization. Effect of cocaine and morphine treatment
    I A Casalinuovo
    Department of Experimental Medicine and Biochemical Sciences, Microbiology, University of Rome Tor Vergata, Italy
    Immunopharmacol Immunotoxicol 22:35-48. 2000
    ..The results showed that non-viable Candida cells of this strain induce a predominant Th0 response. This immune effect is in part impaired only by a subchronic administration of morphine...
  66. ncbi Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats
    G Sireci
    Institute of General Pathology, University of Palermo, Italy
    Immunopharmacol Immunotoxicol 21:583-98. 1999
    ....
  67. ncbi [Serum adenosine deaminase as a parameter for activity in sarcoidosis]
    E Wetzel
    Krankenanstalt, , Akademisches Lehrkrankenhaus,
    Pneumologie 53:323-8. 1999
    ..In comparison to the other parameters, measurement of the serum ADA indicates a greater discrimination between active and inactive disease...
  68. ncbi Inducing a cell-mediated immune response against peptides of the Plasmodium vivax circumsporozoite protein
    B E Thomas
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Ann Trop Med Parasitol 95:573-86. 2001
    ..vivax sporozoites...
  69. ncbi [Spinach powder-induced exogenous allergic alveolitis]
    J Schreiber
    Forschungszentrum Borstel, Medizinische Klinik
    Pneumologie 52:61-5. 1998
    ..24 hours after exposure bronchoalveolar lavage showed an increase of neutrophils. In lung parenchyma mononuclear interstitial infiltrates and an epitheloid cell granuloma were seen...
  70. ncbi Modulation of the interleukin 2 receptor by maternal and cord blood serum
    Y E Vanderbeeken
    Department of Immunology, Hospital St-Pierre, Brussels, Belgium
    Immunopharmacol Immunotoxicol 12:211-36. 1990
    ..However, at physiological concentrations of IgG, the Interleukin 2 receptor downregulation becomes irreversible.
  71. ncbi Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia
    N Muller
    Psychiatric Hospital, Ludwig Maximilian University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 247:308-13. 1997
    ..This suggests that neuroleptic therapy has a differentiated immunomodulatory effect...
  72. ncbi [Study on cellular immunity in children with respiratory syncytial virus associated acute lower respiratory infection]
    Z Chen
    Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:263-6. 1997
    ..These results suggested that human body had a functional disturbance in cellular immunity when infected with RSV...
  73. ncbi Histamine and cytokine therapy
    K Hellstrand
    Department of Virology, , Sweden
    Acta Oncol 37:347-53. 1998
    ..The potential benefit of histamine therapy in melanoma and AML will be evaluated in randomized trials...
  74. ncbi Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes
    C N Baxevanis
    Department of Immunology, Hellenic Anticancer Institute, Athens, Greece
    Immunopharmacol Immunotoxicol 12:595-617. 1990
    ..These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems...
  75. ncbi Correlation of serum interleukin-2 levels, soluble interleukin-2 receptors and T lymphocyte subsets in cancer patients
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
    Tumori 76:14-7. 1990
    ..These results would suggest that metastatic dissemination is associated with a decreased IL-2 production in vivo, and that reduced IL-2 production is more frequent in patients with low CD4/CD8 ratio...
  76. ncbi Re-infection in human schistosomiasis mansoni: a prospective field study 18 months after praziquantel therapy
    K Zwingenberger
    , Berlin
    Ann Trop Med Parasitol 84:457-65. 1990
    ..Both soluble CD8 antigen and interleukin 2 receptor in patients' sera were significantly elevated throughout the study period...
  77. ncbi Interleukin 1 and interferon-gamma: cytokines that provide reciprocal regulation of macrophage and T cell function
    R M Schultz
    Department of Immunology Research, Lilly Research Laboratories, Indianapolis, Indiana 46285
    Toxicol Pathol 15:333-7. 1987
    ..induces activation and replication of several subsets of precursor lymphocytes, including cytotoxic T cells, lymphokine-activated killer (LAK) cells, and natural killer (NK) cells, and enhances their cytotoxic activity for tumor ..
  78. ncbi Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints
    Y T Konttinen
    Fourth Department of Medicine, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 15:387-90. 1990
    ....
  79. ncbi Circulating soluble IL-2 receptor levels are low in patients with hypothyroid autoimmune thyroiditis
    A Loviselli
    Institute of Internal Medicine, University of Cagliari, Italy
    Horm Metab Res 26:548-51. 1994
    ..In our report we studied circulating soluble interleukin 2 receptors in 22 patients with hypothyroid autoimmune thyroiditis before L-thyroxine treatment and when the ..
  80. ncbi Enhancement of methotrexate cytotoxicity by modulation of proliferative activity in normal and neoplastic T lymphocytes and in a myeloid leukemia cell line
    C Ciaiolo
    Amedeo di Savoia Hospital, Turin, Italia
    Tumori 74:537-42. 1988
    ..The truth of this hypothesis was investigated by studying the effect of phytohemagglutinin and/or interleukin 2 on the sensitivity to methotrexate (MTX) of normal T lymphocytes and of lymphoblasts of a patient with acute T-..
  81. ncbi Allogeneic bone marrow transplantation. Recent developments and the potential expansion of the donor pool
    H G Prentice
    Bone Marrow Transplant Programme, Royal Free Hospital and Medical School, Hampstead, England
    Acta Oncol 27:567-70. 1988
    ..Of further interest will be the potential for application of lymphokines (e.g. IL2) without increasing the risk of lethal graft versus host disease...
  82. ncbi The effect of interferon on activated peripheral blood T lymphocytes in patients with chronic active hepatitis B
    M Raptopoulou-Gigi
    2nd Medical Department, Aristotelian University, Thessaloniki, Greece
    Immunopharmacol Immunotoxicol 16:577-88. 1994
    ..These results confirm the immunomodulatory effect of interferon and reflect the effect of treatment in the management of the disease...
  83. ncbi Suppressive and enhancing effect of T-2 toxin on murine lymphocyte activation and interleukin 2 production
    P S Holt
    U.S. Department of Agriculture, Veterinary Toxicology and Entomology Research Laboratory, College Station, Texas 77841
    Immunopharmacol Immunotoxicol 10:365-85. 1988
    ..shown previously to exert potent immunosuppressive effects, was examined for its effects on activation and interleukin 2 (IL 2) production by murine and rat splenocytes...
  84. ncbi Plasma-soluble interleukin-2 and transferrin receptor in schizophrenia and major depression
    M Maes
    University Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium
    Eur Arch Psychiatry Clin Neurosci 244:325-9. 1995
    ..It is suggested that schizophrenia and major depression are characterized by immune disorders that may indicate activation of cell-mediated immunity such as T-cell activation...
  85. ncbi Modulating effects on CD25 and CD71 antigen expression by lectin-stimulated T lymphocytes in the elderly
    S Antonaci
    University of Bari Medical Faculty, Italy
    Immunopharmacol Immunotoxicol 13:87-100. 1991
    ..observations outline that the impaired T lymphocyte proliferative capacity in the elderly is due to a reduced interleukin 2 (IL-2) release...
  86. ncbi Decreased serum interleukin-2 level in patients with chronic headache
    T Shimomura
    Division of Neurology, Tottori University Faculty of Medicine, Yonago, Japan
    Headache 31:310-3. 1991
    ..The decreased serum IL-2 level, observed in this study, might reflect a reduction in 5-HT or catecholamine levels in CNS in the patients with migraine or TH...
  87. ncbi Sodium aurothiomalate inhibits T cell responses to interleukin-2
    M Harth
    Rheumatic Diseases Unit, University Hospital, University of Western Ontario, London, Canada
    Immunopharmacol Immunotoxicol 10:141-56. 1988
    ..These effects of SATM may explain some of the conflicting data in the literature on T cell responses to IL-2 in rheumatoid arthritis (RA), and suggest a possible mechanism of action for the drug in the treatment of RA...
  88. ncbi Evaluation of cellular immune responses and soluble mediators in patients with chronic hepatitis C virus (cHCV) infection
    E Jirillo
    Faculty of Medicine, University of Bari, Italy
    Immunopharmacol Immunotoxicol 17:347-64. 1995
    ..In conclusion, the overall results indicate a condition of peripheral immune depression in cHCV patients with an exaggerated shedding of various mediators endowed with noxious effects for the host...
  89. ncbi Mechanism of phosphatidylserine-induced inhibition of interleukin 2 synthesis in the human T cell line Jurkat
    P Claudette
    , INSERM U210, , Pasteur) Nice, France
    Immunopharmacol Immunotoxicol 12:633-45. 1990
    ....
  90. ncbi Serum levels of cytokines and soluble cytokine receptors in patients with metastatic renal cell carcinoma or malignant melanoma receiving IL-2/interferon-alpha combination therapy
    S D Fossa
    Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo
    Acta Oncol 34:599-603. 1995
    ..In most patients the increase of sIL-2R and sTNFRs lasted for at least 3 weeks after treatment discontinuation. The clinical significance of the increase remains unknown...
  91. ncbi Increased level of soluble interleukin-2 receptor in advanced solid tumors: a preliminary study
    F Rovelli
    Laboratorio di Radioimmunologia, Ospedale San Gerardo, Milano, Italia
    Tumori 74:633-7. 1988
    ..Further studies will be needed to establish if elevated concentrations of IL-2R in the serum can contribute to the immunoincompetence of patients with disseminated solid neoplasms...
  92. ncbi Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol
    M Maes
    CRC-MH, Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium
    Eur Arch Psychiatry Clin Neurosci 245:172-8. 1995
    ..There were also significant positive correlations between plasma prolactin and sIL-2R concentrations in major depressed subjects and in the combined groups of normal and major depressed subjects...
  93. ncbi [Sarcoidosis of the lung: clinical course and inflammatory activity]
    M Schmidt

    Pneumologie 49:226-32. 1995
    ..Hence, acute lymphocytic inflammation is a favourable prognostic sign and should not prompt premature treatment with cortisone...
  94. ncbi Intracavitary administration of interleukin-2 as palliative therapy for neoplastic effusions
    P Lissoni
    Divisione di Radioterapia Oncologica, Ospedale S. Gerardo, Monza, Milano, Italy
    Tumori 78:118-20. 1992
    ..No important toxicity was seen. This preliminary study showed that low dose IL-2 given intracavitarily is an effective and well-tolerated therapy in patients with neoplastic effusions...
  95. ncbi Mechanism of action of prothymosin alpha in the human autologous mixed lymphocyte response
    C N Baxevanis
    Department of Immunology, Hellenic Anticancer Institute, Athens, Greece
    Immunopharmacol Immunotoxicol 10:443-61. 1988
    ..In addition, ProT alpha-sup did not demonstrate any detectable interleukin 1 (IL 1) or interleukin 2 (IL 2) - like activity...
  96. ncbi Peripheral blood and tumor infiltrating lymphocytes in non-small cell lung cancer: analysis at the population and clonal level
    M Viale
    Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Farmacologia, Genova, Italy
    Tumori 76:488-94. 1990
    ..Moreover, most PBL- and TIL-derived clones released tumor necrosis factor alpha in response to mitogen stimulation...
  97. ncbi Histamine blocks interleukin 2 (IL-2) gene expression and regulates IL-2 receptor expression
    A R Rezai
    Department of Microbiology and Immunology, UCLA School of Medicine 90024
    Immunopharmacol Immunotoxicol 12:345-62. 1990
    ..In addition, histamine seems to exert immunomodulating effects on IL-2 receptor expression, particularly in those individuals with AIDS-KS...
  98. ncbi [Monitoring sarcoidosis therapy with immunopathologic parameters]
    J Muller-Quernheim
    III Med Klinik, Schwerpunkt Pneumologie, Johannes Gutenberg Universitat, Mainz
    Pneumologie 48:47-9. 1994
    ..Bronchoalveolar lavage yields different cytological patterns typical for the acute and chronic forms of the disease permitting the identification of the subpopulation on risk for functional deterioration...
  99. ncbi Effect of cytokines on cytosolic-free calcium in human platelets from essential hypertensives
    M Tepel
    , , Germany
    Am J Hypertens 6:660-6. 1993
    ..Erythropoietin (EPO) and interleukin 2 significantly increased platelet [Ca2+]i, whereas platelet-derived growth factor, and fibroblast growth factor ..
  100. ncbi Subcutaneous low-dose interleukin-2 plus alpha interferon in advanced malignant melanoma
    F de Braud
    Divisione di Oncologia Medica B, Istituto Nazionale per la Cura e lo Studio dei Tumori, Milano, Italy
    Tumori 79:187-90. 1993
    ..The good patient compliance makes this schedule eligible to evaluate whether IL-2 plus rIFN-alpha can enhance the results of chemotherapy in this disease...

Research Grants157 found, 100 shown here

  1. DCTD Biopharmaceutical Development - Type 1 Diabetes RAID projects
    LARRY ARTHUR; Fiscal Year: 2009
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  2. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2009
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  3. DCTD Biopharmaceutical Development
    LARRY ARTHUR; Fiscal Year: 2010
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  4. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2012
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  5. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2011
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  6. DCTD Biopharmaceutical Development
    David Heimbrook; Fiscal Year: 2013
    ..The BDP scientific staff members continued to be active within the extramural community, serving on academic faculties and advisory committees, and presenting scientific findings at national and international meetings. ..
  7. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..We propose to study the complex interplay of environmental, immunological and genetic factors to discover molecular signatures with a potential to advance clinical diagnosis and therapy at or before the onset of T1D. ..
  8. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..The BMT/CTN including our consortium will be the only clinical cooperative group to accomplish this goal. ..
  9. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  10. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN?)...
  11. Structural basis of Jak3-mediated interleukin-2 family signal transduction
    TITUS JONATHON BOGGON; Fiscal Year: 2010
    ..These studies will directly impact healthcare stimulating the development of improved immunomodulatory and anti-proliferative therapies and by enhancing molecular-level understanding of cytokine signaling pathways. ..
  12. Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    MANUEL L contact PENICHET; Fiscal Year: 2010
    ....
  13. Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    Manuel L Penichet; Fiscal Year: 2013
    ..A novel nanobiopolymer-based therapy against HER2/neu expressing cancer cells with sufficient capacity to inhibit angiogenesis and orchestrate an anti-tumor immune response should make a significant clinical impact. ..
  14. Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    Manuel L Penichet; Fiscal Year: 2013
    ..A novel nanobiopolymer-based therapy against HER2/neu expressing cancer cells with sufficient capacity to inhibit angiogenesis and orchestrate an anti-tumor immune response should make a significant clinical impact. ..
  15. New Strategies to Prevent Death from Influenza
    Kendall A Smith; Fiscal Year: 2010
    ..If successful, this research effort will provide the foundation for the development of a universal approach to the prevention and treatment of one of the world's most dangerous microbes, one that kills hundreds of thousands yearly. ..
  16. Role of MEK1 in T cell function in asthma
    Rafeul Alam; Fiscal Year: 2013
    ..The proposal is important because it addresses the mechanism of persistence of airway inflammation in asthma. The results of this study will lead to the development of novel therapeutic modalities for asthma. ..
  17. The Role of EOS in Regulatory T-cell Biology.
    Drew M Pardoll; Fiscal Year: 2010
    ..This proposal explore mechanism of Eos dependent Gene silencing and test the hypothesis that regulation of Eos is an important mechanism to control the regulatory T cell/ effector T cell balance in immunity. ..
  18. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    NORBERT EDWARD KAMINSKI; Fiscal Year: 2010
    ..This project assesses the consequences of cannabis on immunity against HIV and the common pathogen, influenza, which afflicts immune compromised individuals at a higher incidence. ..
  19. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert E Kaminski; Fiscal Year: 2012
    ..This project assesses the consequences of cannabis on immunity against HIV and the common pathogen, influenza, which afflicts immune compromised individuals at a higher incidence. ..
  20. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert Kaminski; Fiscal Year: 2009
    ..This project assesses the consequences of cannabis on immunity against HIV and the common pathogen, influenza, which afflicts immune compromised individuals at a higher incidence. ..
  21. The Role of EOS in Regulatory T-cell Biology.
    Drew M Pardoll; Fiscal Year: 2013
    ....
  22. VEGI-192 As An Anticancer Therapeutic Agent
    LUYUAN LI; Fiscal Year: 2010
    ....
  23. Genetic and Functional Analysis of IL-2 Deficiency in Lupus-Prone Mice
    Zhiwei Xu; Fiscal Year: 2010
    ..Our design of this project aims at identifying the gene responsible for the IL-2 deficiency and elucidating its roles in lupus pathogenesis, which will contribute to discovering a new therapeutic target for lupus treatment. ..
  24. Genetic and Functional Analysis of IL-2 Deficiency in Lupus-Prone Mice
    Zhiwei Xu; Fiscal Year: 2013
    ..Our design of this project aims at identifying the gene responsible for the IL-2 deficiency and elucidating its roles in lupus pathogenesis, which will contribute to discovering a new therapeutic target for lupus treatment. ..
  25. Mechanisms of invariant NKT cell-mediated in vivo anti-tumor responses
    Hamid Bassiri; Fiscal Year: 2013
    ..abstract_text> ..
  26. Bridging Pediatric and Adult Biomarkers of Graft-Versus-Host-Disease
    Jamie L Renbarger; Fiscal Year: 2013
    ..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
  27. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert E Kaminski; Fiscal Year: 2013
    ....
  28. Interferon actions and autoimmune disorders
    Michael David; Fiscal Year: 2010
    ..b>Interleukin 2 (IL-2) is powerful mitogen for T cells, and its production is a hallmark of T cell activation...
  29. Development of Intestinal Immune Regulation in Human Infants
    JOERN HENDRIK WEITKAMP; Fiscal Year: 2010
    ..These studies will help identify patients at highest risk and provide the basis for the development of treatments to prevent or ameliorate this, often fatal, disease. ..
  30. Role of BCL11B in CD4+ T Cells
    Dorina Avram; Fiscal Year: 2010
    ..In addition, these studies will enhance our understanding of the transcriptional control of late stages of T cell development and mature CD4 T cell function, and have important implications for autoimmune diseases. ..
  31. MOLECULAR ENGINEERING OF IL-2 FOR THE TREATMENT AND PREVENTION OF TYPE I DIABETES
    AARON MICHAEL RING; Fiscal Year: 2013
    ..Thus, through these multidisciplinary and translational studies, we will advance new candidate T1D therapies for clinical development. ! ..
  32. MOLECULAR ENGINEERING OF IL-2 FOR THE TREATMENT AND PREVENTION OF TYPE I DIABETES
    AARON MICHAEL RING; Fiscal Year: 2012
    ..Thus, through these multidisciplinary and translational studies, we will advance new candidate T1D therapies for clinical development. ! ..
  33. Development of Intestinal Immune Regulation in Human Infants
    JOERN HENDRIK WEITKAMP; Fiscal Year: 2013
    ..This proposal develops novel translational approaches to identify cellular and molecular targets for reducing the pathologic host immune response in NEC and to detect infants at highest risk of this devastating disease. ..
  34. Pathophysiology of Adult T-cell Leukemia/Lymphoma
    UTPAL P DAVE; Fiscal Year: 2013
    ..Our aims are well-timed and can have a significant impact on a disease that is universally fatal upon diagnosis and advance our understanding of JAK3's role in T-cell neoplasia. ..
  35. Regulatory T Cell-Deficient Mouse Model Rapidly Develops Sjogren's Syndrome
    Shyr Te Ju; Fiscal Year: 2010
    ..This study should identify new and useful models for Sjogren's syndrome research. It should identify new mechanism(s) for the pathogenesis of the disease and provide potential treatment of the disease. ..
  36. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  37. Signal transduction and gene induction in lymphocytes
    Anjana Rao; Fiscal Year: 2012
    ..We expect to identify new regulatory proteins that will provide novel therapies for autoimmunity and other important diseases. ..
  38. The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis
    Lucile E Wrenshall; Fiscal Year: 2010
    ..The proposed research is of great significance to public health, given the prevalence of cardiovascular disease in the United States. ..
  39. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2011
    ..We will also analyze the mechanisms of the autoimmune disease caused by the absence of IL-2, and determine if different amounts and duration of IL-2 administration can be used to differentially activate effector cells and Treg. ..
  40. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  41. The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis
    Lucile E Wrenshall; Fiscal Year: 2011
    ..The proposed research is of great significance to public health, given the prevalence of cardiovascular disease in the United States. ..
  42. The Role of KIR and FcR Genotype in the Efficacy of mAb and IL2 Immunotherapy
    Paul M Sondel; Fiscal Year: 2013
    ....
  43. INTERLEUKIN 2 RECEPTOR AND T LYMPHOCYTE GROWTH
    THOMAS MALEK; Fiscal Year: 1999
    b>Interleukin 2 (IL-2) is a key growth factor for the clonal expansion of antigen activated T lymphocytes whose biological activity is mediated by binding to the high affinity IL-2 receptor (IL-2R), comprised of 3 subunits, alpha, beta and ..
  44. Signal transduction and gene induction in lymphocytes
    Anjana Rao; Fiscal Year: 2013
    ....
  45. Adoptive Transfer of MART-1 TCR Engineered Cells after a Myelodepleting Regimen
    Antoni Ribas; Fiscal Year: 2011
    ..In summary, we propose to test tumor antigen-specific TCR transgenic cell adoptive transfer in a bench-tobedside and bedside-to-bench clinical research project. ..
  46. MOLECULAR AND CELLULAR ANALYSIS OF G PROTEIN FUNCTION
    Catherine H Berlot; Fiscal Year: 2010
    ..the small molecule, 1 gallein, leads to increased T cell receptor (TCR)-stimulated production of the cytokine, interleukin 2 (IL-2) in CD4+ T cells...
  47. Re-activating Memory T Cells in the Microenvironment of Human Tumors
    Richard B Bankert; Fiscal Year: 2011
    ..These studies are expected to lay the foundation for the design of strategies that can be used to enhance the efficacy of our current cancer vaccination clinical trials. ..
  48. Arginine Availability, Modulated by MDSC, Regulates T Cell Function in Cancer
    Augusto C Ochoa; Fiscal Year: 2011
    ..Cancer vaccines and cytokines can be an important therapeutic approach for patients whose tumors have failed standard forms of treatment. ..
  49. Arginine Availability, Modulated by MDSC, Regulates T Cell Function in Cancer
    Augusto C Ochoa; Fiscal Year: 2013
    ..Cancer vaccines and cytokines can be an important therapeutic approach for patients whose tumors have failed standard forms of treatment. ..
  50. Manipulation of Immune Responsiveness after Hematopoietic Cell Transplantation
    ROBERT JON SOIFFER; Fiscal Year: 2013
    ..PROJECT/PERFORMANGE SITE(S) (if additional space is needed, use Project/Perfonnance Site Fonnat Page) ..
  51. Expression profiling of renal cell carcinoma utilizing tissue from CALGB 90206
    Hyung L Kim; Fiscal Year: 2010
    ....
  52. Expression profiling of renal cell carcinoma utilizing tissue from CALGB 90206
    Hyung L Kim; Fiscal Year: 2009
    ....
  53. MOLECULAR AND CELLULAR ANALYSIS OF G PROTEIN FUNCTION
    Catherine H Berlot; Fiscal Year: 2013
    ..the small molecule, 1 gallein, leads to increased T cell receptor (TCR)-stimulated production of the cytokine, interleukin 2 (IL-2) in CD4+ T cells...
  54. DESIGN OF MULTIMERIC INTERLEUKIN-2 RECEPTOR ECTODOMAINS
    Thomas Ciardelli; Fiscal Year: 1999
    ..4. To obtain detailed structure-activity data on these complexes by co-crystallizing them with IL-2 and determining their X-ray structures to high resolution. ..
  55. THE INTERLEUKIN 2 RECEPTOR & T LYMPHOCYTE GROWTH
    THOMAS MALEK; Fiscal Year: 1991
    b>Interleukin 2 (IL-2) is the major growth factor for T lymphocytes and plays a critical role in the regulation of specific immune responses...
  56. INTERLEUKIN 2 RECEPTOR AND T LYMPHOCYTE GROWTH
    THOMAS MALEK; Fiscal Year: 1990
    b>Interleukin 2 (IL-2) is the major growth factor for T lymphocytes and plays a critical role in the regulation of specific immune responses...
  57. DESIGN OF MULTIMERIC INTERLEUKIN-2 RECEPTOR ECTODOMAINS
    Thomas Ciardelli; Fiscal Year: 2000
    ..4. To obtain detailed structure-activity data on these complexes by co-crystallizing them with IL-2 and determining their X-ray structures to high resolution. ..
  58. THE INTERLEUKIN 2 RECEPTOR & T LYMPHOCYTE GROWTH
    THOMAS MALEK; Fiscal Year: 1993
    b>Interleukin 2 (IL-2) is the major growth factor for T lymphocytes and plays a critical role in the regulation of specific immune responses...
  59. INTERLEUKIN 2 RECEPTOR & T LYMPHOCYTE GROWTH
    THOMAS MALEK; Fiscal Year: 1992
    b>Interleukin 2 (IL-2) is the major growth factor for T lymphocytes and plays a critical role in the regulation of specific immune responses...
  60. Structural basis of Jak3-mediated interleukin-2 family signal transduction
    TITUS BOGGON; Fiscal Year: 2009
    ..These studies will directly impact healthcare stimulating the development of improved immunomodulatory and anti-proliferative therapies and by enhancing molecular-level understanding of cytokine signaling pathways. ..
  61. Structural basis of Jak3-mediated interleukin-2 family signal transduction
    TITUS BOGGON; Fiscal Year: 2007
    ..These studies will directly impact healthcare stimulating the development of improved immunomodulatory and anti-proliferative therapies and by enhancing molecular-level understanding of cytokine signaling pathways. ..
  62. Bifunctional T cell receptor based immunotherapeutics
    Hing C Wong; Fiscal Year: 2010
    ..This may lead to a safe and effective approach to treat patients with refractory, metastatic cancer. ..
  63. Bifunctional T cell receptor based immunotherapeutics
    Hing Wong; Fiscal Year: 2009
    ..This may lead to a safe and effective approach to treat patients with refractory, metastatic cancer. ..
  64. CANCER THERAPY WITH ACTIVATED NATURAL KILLER CELLS
    Ronald Herberman; Fiscal Year: 1999
    ..efficacy of lymphokine-activated killer (LAK) cells when administered in combination with high dose interleukin 2 (IL2), and the demonstration that most LAK activity is attributable to IL2-activated NK cells, the therapeutic ..
  65. CANCER THERAPY WITH ACTIVATED NATURAL KILLER CELLS
    Ronald Herberman; Fiscal Year: 2000
    ..efficacy of lymphokine-activated killer (LAK) cells when administered in combination with high dose interleukin 2 (IL2), and the demonstration that most LAK activity is attributable to IL2-activated NK cells, the therapeutic ..
  66. RENAL CELL CARCINOMA--ADOPTIVE IMMUNOTHERAPY
    KURT STENZEL; Fiscal Year: 1990
    ..Methodology and feasibility for on-line activation of lymphoid cells for adoptive immunotherapy will be investigated using a murine tumor model...
  67. EFFECTS OF PHORBOL ESTERS ON LYMPHOCYTE STIMULATION
    Andrea Mastro; Fiscal Year: 1990
    ..Mitogenic lectins along with macro-phages induce production of interleukin 1 (IL1), interleukin 2 (IL2), and their receptors which interact to cause proliferation. These interactions are not well understood...
  68. ROLE OF T & B CELL STIMULATORY CYTOKINES IN SLE
    CHARLES VIA; Fiscal Year: 1992
    ..In vivo mAb will be given at the onset of GVHD to determine if mAb treatment can block disease development. In later studies, mAb will be delayed until 2 weeks after SLE GVHD induction to determine if established disease can be reversed...
  69. IMMUNOREGULATION OF ERYTHROPOIESIS
    Lee Levitt; Fiscal Year: 1990
    ..assess how triggering CD2 with a defined ligand, or with CD2-activating monoclonal antibodies, modulates T cell growth factor production and erythroid regulation...
  70. TUMOR SPECIFIC TIL FROM RENAL CANCER
    Arie Belldegrun; Fiscal Year: 1990
    Systemic administration of recombinant human interleukin 2 (IL 2)-expanded tumor infiltrating lymphocytes (TIL) obtained from freshly resected surgical specimens is an experimental approach to adoptive immunotherapy of cancer...
  71. IL2 RECEPTORS--ANALYSIS OF ASSEMBLY AND SIGNALING
    Warner Greene; Fiscal Year: 1999
    ....
  72. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..Ultimately, this approach may provide a safer and more effective treatment for patients with cancer than the currently approved immunotherapies. ..
  73. NCI CLINICAL INVESTIGATOR AWARD
    David Peace; Fiscal Year: 1990
    The lymphokine Interleukin 2 (IL2) was first recognized for its ability to induce the proliferation of T cells activated by antigen or mitogen to express IL2 receptors...