integrin alpha v


Gene Symbol: integrin alpha v
Description: integrin subunit alpha V
Alias: CD51, MSK8, VNRA, VTNR, integrin alpha-V, antigen identified by monoclonal antibody L230, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), vitronectin receptor subunit alpha
Species: human
Products:     integrin alpha v

Top Publications

  1. Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, et al. Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Res. 1999;59:5307-14 pubmed
    ..These data show that uPAR association with alpha(v)beta5 leads to a functional interaction of these receptors and suggest that uPAR directs cytoskeletal rearrangements and cell migration by altering alpha(v)beta5 signaling specificity. ..
  2. Xiong J, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman S, et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 2002;296:151-5 pubmed
    ..Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence...
  3. Ashton A, Cheng Y, Helisch A, Ware J. Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3. Circ Res. 2004;94:735-42 pubmed
  4. van der Horst G, van den Hoogen C, Buijs J, Cheung H, Bloys H, Pelger R, et al. Targeting of ?(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia. 2011;13:516-25 pubmed
  5. McDonald J, Zheleznyak A, Frazier W. Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity. J Biol Chem. 2004;279:17301-11 pubmed
  6. Beer A, Haubner R, Sarbia M, Goebel M, Luderschmidt S, Grosu A, et al. Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clin Cancer Res. 2006;12:3942-9 pubmed
    ..PET with [18F]Galacto-RGD might therefore be used as a new marker of angiogenesis and for individualized planning of therapeutic strategies with alpha(v)beta3-targeted drugs. ..
  7. Mikelis C, Sfaelou E, Koutsioumpa M, Kieffer N, Papadimitriou E. Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta. FASEB J. 2009;23:1459-69 pubmed publisher
    ..Collectively, these data suggest that alpha(nu)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of PTN on cell migration. ..
  8. Mahabeleshwar G, Feng W, Reddy K, Plow E, Byzova T. Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res. 2007;101:570-80 pubmed
  9. Lössner D, Abou Ajram C, Benge A, Aumercier M, Schmitt M, Reuning U. Integrin alphavbeta3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription. J Cell Physiol. 2009;220:367-75 pubmed publisher
    We previously showed that integrin alphavbeta3 overexpression and engagement by its ligand vitronectin increased adhesion, motility, and proliferation of human ovarian cancer cells...

More Information


  1. Alghisi G, Ponsonnet L, Ruegg C. The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS ONE. 2009;4:e4449 pubmed publisher
    ..These effects are potentially relevant to the clinical use of cilengitide as anticancer agent. ..
  2. Porter J, Hogg N. Integrins take partners: cross-talk between integrins and other membrane receptors. Trends Cell Biol. 1998;8:390-6 pubmed
    ..Here, Joanna Porter and Nancy Hogg discuss a few of the best characterized of these specialist integrin partnerships. ..
  3. Barillari G, Sgadari C, Palladino C, Gendelman R, Caputo A, Morris C, et al. Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. J Immunol. 1999;163:1929-35 pubmed
  4. Byzova T, Kim W, Midura R, Plow E. Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein. Exp Cell Res. 2000;254:299-308 pubmed
    ..The constitutive activation of alpha(V)beta(3) on neoplastic cells may contribute to tumor growth and metastatic potential. ..
  5. Chen W, Lou J, Hsin J, Schulten K, Harvey S, Zhu C. Molecular dynamics simulations of forced unbending of integrin ?(v)??. PLoS Comput Biol. 2011;7:e1001086 pubmed publisher
    ..These results reveal the dynamic processes and pathways of integrin conformational changes with atomic details and provide new insights into the structural mechanisms of integrin activation. ..
  6. Mori S, Wu C, Yamaji S, Saegusa J, Shi B, Ma Z, et al. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008;283:18066-75 pubmed publisher
    ..We discovered that FGF1 directly bound to soluble and cell-surface integrin alphavbeta3 (K(D) about 1 microm)...
  7. Zhang H, Li Z, Viklund E, Stromblad S. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. J Cell Biol. 2002;158:1287-97 pubmed
    ..integrin beta 5 subunit, an association that was also found in mammalian cells between endogenous PAK4 and integrin alpha v beta 5...
  8. Cooper C, Chay C, Pienta K. The role of alpha(v)beta(3) in prostate cancer progression. Neoplasia. 2002;4:191-4 pubmed
    ..These biological events require the activation of focal adhesion kinase and the subsequent activation of PI-3 kinase/Akt signaling pathway. ..
  9. Mu D, Cambier S, Fjellbirkeland L, Baron J, Munger J, Kawakatsu H, et al. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002;157:493-507 pubmed
    ..These data elucidate a novel mechanism of cellular homeostasis achieved through the coordination of the activities of members of three major gene families involved in cell-matrix interactions. ..
  10. Liu L, Craig A, Meldrum H, Marcovina S, Elliott B, Koschinsky M. Apolipoprotein(a) stimulates vascular endothelial cell growth and migration and signals through integrin alphaVbeta3. Biochem J. 2009;418:325-36 pubmed publisher
    ..In addition, we showed that LM609, the function-blocking antibody to integrin alphaVbeta3, abrogated the effects of 17K r-apo(a) and Lp(a) on HUVECs...
  11. Saegusa J, Yamaji S, Ieguchi K, Wu C, Lam K, Liu F, et al. The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. J Biol Chem. 2009;284:24106-14 pubmed publisher
    It has been proposed that ligand occupancy of integrin alphavbeta3 with extracellular matrix ligands (e.g. vitronectin) plays a critical role in insulin-like growth factor-1 (IGF-1) signaling...
  12. Chang S, Chang C, Lee D, Lee P, Yeh Y, Yeh C, et al. Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. Proc Natl Acad Sci U S A. 2008;105:3927-32 pubmed publisher
  13. Saegusa J, Akakura N, Wu C, Hoogland C, Ma Z, Lam K, et al. Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner. J Biol Chem. 2008;283:26107-15 pubmed publisher
    ..Thus sPLA2-IIA receptors in human have not been established. Here we demonstrated that sPLA2-IIA bound to integrin alphavbeta3 at a high affinity (K(D)=2 x 10(-7) M)...
  14. Chesnokova L, Hutt Fletcher L. Fusion of Epstein-Barr virus with epithelial cells can be triggered by ?v?5 in addition to ?v?6 and ?v?8, and integrin binding triggers a conformational change in glycoproteins gHgL. J Virol. 2011;85:13214-23 pubmed publisher
    ..Overall, the data are consistent with the interaction of gHgL with an integrin inducing a functionally important rearrangement at the domain I-domain II interface...
  15. Xiong J, Mahalingham B, Alonso J, Borrelli L, Rui X, Anand S, et al. Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment. J Cell Biol. 2009;186:589-600 pubmed publisher
  16. Li Z, Lock J, Olofsson H, Kowalewski J, Teller S, Liu Y, et al. Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover. Mol Biol Cell. 2010;21:3317-29 pubmed publisher
    ..We thus demonstrate a novel mechanism deployed by cells to tune cell adhesion levels through the autoinhibitory regulation of integrin adhesion. ..
  17. Desgrosellier J, Lesperance J, Seguin L, Gozo M, Kato S, Franovic A, et al. Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell. 2014;30:295-308 pubmed publisher
    ..Thus, pregnancy-associated MaSCs require a TGF-β2/αvβ3/Slug pathway, which may contribute to breast cancer progression and stemness. ..
  18. Xiong J, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott D, et al. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science. 2001;294:339-45 pubmed
    ..We have solved the crystal structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution. Its 12 domains assemble into an ovoid "head" and two "tails...
  19. Nejjari M, Hafdi Z, Gouysse G, Fiorentino M, Beatrix O, Dumortier J, et al. Expression, regulation, and function of alpha V integrins in hepatocellular carcinoma: an in vivo and in vitro study. Hepatology. 2002;36:418-26 pubmed
    ..In conclusion, our results support the existence of an alpha V integrin/vitronectin connection in hepatocellular carcinoma and suggest that this connection may be an adverse prognostic factor. ..
  20. Defilles C, Montero M, Lissitzky J, Rome S, Siret C, Luis J, et al. ?v integrin processing interferes with the cross-talk between ?v?5/?6 and ?2?1 integrins. Biol Cell. 2011;103:519-29 pubmed publisher
    ..The endoproteolytic cleavage of ?v subunits is necessary for ?v?5/?6 integrin to control ?2?1 function and could thus play an essential role in colon cancer cell migration. ..
  21. Rolli M, Fransvea E, Pilch J, Saven A, Felding Habermann B. Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc Natl Acad Sci U S A. 2003;100:9482-7 pubmed
    Expression of adhesion receptor integrin alphavbeta3 in an activated functional form strongly promotes metastasis in human breast cancer cells...
  22. Chen Y, Wei Y, Chen H, Fong Y, Hsu C, Tsai C, et al. Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. J Cell Physiol. 2009;221:98-108 pubmed publisher
    ..Taken together, our results indicated that OPN enhances the migration of chondrosarcoma cells by increasing MMP-9 expression through the alphavbeta3 integrin, FAK, MEK, ERK and NF-kappaB signal transduction pathway. ..
  23. Faccio R, Grano M, Colucci S, Villa A, Giannelli G, Quaranta V, et al. Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts. J Cell Sci. 2002;115:2919-29 pubmed
    ..The capacity of growth factors to alter the affinity of alpha(v)beta(3) toward its ligands offers a potential explanation for the diverse responses of osteoclasts to the same ligand. ..
  24. Maubant S, Saint Dizier D, Boutillon M, Perron Sierra F, Casara P, Hickman J, et al. Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells. Blood. 2006;108:3035-44 pubmed
    ..Altogether, these findings have important implications for the development of this class of antiangiogenics. ..
  25. Genersch E, Ferletta M, Virtanen I, Haller H, Ekblom P. Integrin alphavbeta3 binding to human alpha5-laminins facilitates FGF-2- and VEGF-induced proliferation of human ECV304 carcinoma cells. Eur J Cell Biol. 2003;82:105-17 pubmed
    ..Solid-phase binding assays confirmed that integrin alphavbeta3 binds human laminin-10/11 and -10, in an RGD-dependent fashion...
  26. Deryugina E, Ratnikov B, Postnova T, Rozanov D, Strongin A. Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase. J Biol Chem. 2002;277:9749-56 pubmed
    ..Regulation of integrin maturation and functionality may be an important role of MT1-MMP in tumor cells. ..
  27. Pilch J, Habermann R, Felding Habermann B. Unique ability of integrin alpha(v)beta 3 to support tumor cell arrest under dynamic flow conditions. J Biol Chem. 2002;277:21930-8 pubmed
    ..We conclude that the presence of alpha(v)beta3 in a functionally activated state provides a unique advantage for circulating tumor cells by promoting tumor cell arrest in the presence of flow-dependent shear forces. ..
  28. Lorger M, Krueger J, O Neal M, Staflin K, Felding Habermann B. Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain. Proc Natl Acad Sci U S A. 2009;106:10666-71 pubmed publisher
    ..Targeting this molecular mechanism could prove valuable for the inhibition of brain metastasis. ..
  29. Chen P, Wang M, Wu S, Su J, Hong C, Chuang S, et al. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. J Cell Sci. 2007;120:2053-65 pubmed
    ..A neutralizing antibody against integrin alphavbeta3 significantly attenuated CTGF-mediated ERK1/2 activation and cellular migration, indicating that the ..
  30. Jacq L, Garnier S, Dieude P, Michou L, Pierlot C, Migliorini P, et al. The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study. Arthritis Res Ther. 2007;9:R63 pubmed
    ..002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene. ..
  31. Jin Y, Tong D, Chen J, Feng Z, Yang J, Shao C, et al. Overexpression of osteopontin, ?v?3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer. PLoS ONE. 2012;7:e48575 pubmed publisher
  32. Gianni T, Leoni V, Chesnokova L, Hutt Fletcher L, Campadelli Fiume G. ?v?3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. Proc Natl Acad Sci U S A. 2012;109:19792-7 pubmed publisher
    ..We propose that ?v?3-integrin is considered a class of non-TLR pattern recognition receptors, a role likely exerted toward viruses and bacteria that interact with integrins and mount an innate response. ..
  33. Silletti S, Kessler T, Goldberg J, Boger D, Cheresh D. Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci U S A. 2001;98:119-24 pubmed
    ..By disrupting endothelial cell invasion without broadly suppressing cell adhesion or MMP function, the use of compounds such as TSRI265 may provide a novel therapeutic approach for diseases associated with uncontrolled angiogenesis. ..
  34. Fujita M, Takada Y, Takada Y. Integrins ?v?3 and ?4?1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. J Immunol. 2012;189:5809-19 pubmed publisher
    ..These findings suggest that K36E/R37E acts as a dominant-negative CX3CR1 antagonist and that FKN-CD/integrin interaction is a novel therapeutic target in inflammatory diseases. ..
  35. He J, Wang F, Qi H, Li Y, Liang H. Down-regulation of alphav integrin by retroviral delivery of small interfering RNA reduces multicellular resistance of HT29. Cancer Lett. 2009;284:182-8 pubmed publisher
    ..Since force, including adhesion, can activate alphav integrin, cell-cell contact may contribute to activation of alphav integrin, through which increasing phosphorylated p65 and decreasing phosphorylated JNK2 takes part in MCR. ..
  36. Ratnikov B, Rozanov D, Postnova T, Baciu P, Zhang H, DiScipio R, et al. An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase. J Biol Chem. 2002;277:7377-85 pubmed
  37. Barillari G, Sgadari C, Fiorelli V, Samaniego F, Colombini S, Manzari V, et al. The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. Blood. 1999;94:663-72 pubmed
    ..This soluble bFGF mediates Tat-induced vascular cell growth. These effects resemble those of extracellular matrix proteins, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules. ..
  38. Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, Kalluri R. Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A. 2003;100:4766-71 pubmed
    ..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis. ..
  39. Adair B, Xiong J, Maddock C, Goodman S, Arnaout M, Yeager M. Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. J Cell Biol. 2005;168:1109-18 pubmed
    ..The ectodomain of integrin alphaVbeta3 crystallizes in a bent, genuflexed conformation considered to be inactive (unable to bind physiological ..
  40. Felding Habermann B, Fransvea E, O Toole T, Manzuk L, Faha B, Hensler M. Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells. Clin Exp Metastasis. 2002;19:427-36 pubmed
    Early metastasis is the primary cause of death in melanoma patients. The adhesion receptor integrin alpha v beta 3 contributes to tumor cell functions that are potentially involved in melanoma growth and metastasis...
  41. McCabe N, De S, Vasanji A, Brainard J, Byzova T. Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling. Oncogene. 2007;26:6238-43 pubmed
  42. Benelli R, Mortarini R, Anichini A, Giunciuglio D, Noonan D, Montalti S, et al. Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides. AIDS. 1998;12:261-8 pubmed
    ..These same domains attract monocytes. The alpha vbeta3 and beta1 integrins are equally involved in Tat-induced monocyte migration, while the alpha vbeta3 integrin largely mediates the dendritic cell response to Tat. ..
  43. Eliceiri B, Puente X, Hood J, Stupack D, Schlaepfer D, Huang X, et al. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002;157:149-60 pubmed
    ..Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin alpha(v)beta5 into a FAK-containing signaling complex during growth factor-mediated biological responses. ..
  44. Xiong J, Stehle T, Goodman S, Arnaout M. A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem. 2004;279:40252-4 pubmed
    ..This architecture may be relevant to the evolution of integrins and should help refine the current models of integrin activation. ..
  45. Li P, Liu F, SUN L, Zhao Z, Ding X, Shang D, et al. Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin ?v?3. Int J Mol Med. 2011;27:679-87 pubmed publisher
    ..Taken together, our data indicate that CCR7 regulates cell adhesion and migration via integrin ?v?3 in metastatic SCCHN. These results should provide the groundwork for new strategies aimed at preventing SCCHN metastasis. ..
  46. Nishimura S, Sheppard D, Pytela R. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J Biol Chem. 1994;269:28708-15 pubmed
    ..We conclude that the beta 8 cytoplasmic domain, which is structurally unrelated to the conserved cytoplasmic domains of other beta subunits, is functionally distinct. ..
  47. Weinacker A, Chen A, Agrez M, Cone R, Nishimura S, Wayner E, et al. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994;269:6940-8 pubmed
    The integrin alpha v beta 6 has been shown to be a fibronectin-binding protein...
  48. Moyle M, Napier M, McLean J. Cloning and expression of a divergent integrin subunit beta 8. J Biol Chem. 1991;266:19650-8 pubmed
  49. Barillari G, Gendelman R, Gallo R, Ensoli B. The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci U S A. 1993;90:7941-5 pubmed
    ..The results also suggest that RGD-recognizing integrins mediate the vascular cell-growth-promoting effect of Tat. ..
  50. Vogel B, Lee S, Hildebrand A, Craig W, Pierschbacher M, Wong Staal F, et al. A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin. J Cell Biol. 1993;121:461-8 pubmed
    ..These data define an auxiliary integrin binding specificity for basic amino acid sequences. These basic domain binding sites may function synergistically with the binding sites that recognize RGD or equivalent sequences. ..
  51. Avraham H, Lee T, Koh Y, Kim T, Jiang S, Sussman M, et al. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J Biol Chem. 2003;278:36661-8 pubmed
    ..Thus, these studies define a mechanism for the regulatory role of VEGF in focal adhesion complex assembly in HBMECs via activation of FAK and RAFTK/Pyk2. ..
  52. Silletti S, Mei F, Sheppard D, Montgomery A. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J Cell Biol. 2000;149:1485-502 pubmed
  53. Lai T, Fong Y, Fu W, Yang R, Tang C. Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells. J Cell Physiol. 2009;218:334-42 pubmed publisher
    ..Taken together, our results indicate that lung derived-SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway. ..
  54. Hurt E, Chan K, Serrat M, Thomas S, Veenstra T, Farrar W. Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. Stem Cells. 2010;28:390-8 pubmed publisher
    ..Here we show that vitronectin is the component of human serum driving stem cell differentiation through an integrin alpha V beta 3-dependent mechanism...
  55. Garrigues H, Rubinchikova Y, DiPersio C, Rose T. Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. J Virol. 2008;82:1570-80 pubmed
    ..Our studies demonstrate that alpha(V)beta(3) is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD). ..
  56. Cao L, Fan X, Jing W, Liang Y, Chen R, Liu Y, et al. Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-κB-HIF-1α pathway. Oncotarget. 2015;6:6627-40 pubmed
    ..OPN might promote a cancer stem cell-like phenotype via the αvβ3-NF-κB-HIF-1α pathway. Our findings offer strong support for OPN requirement in maintaining stem-like properties in HCC cells. ..