INSIG2

Summary

Gene Symbol: INSIG2
Description: insulin induced gene 2
Alias: INSIG-2, insulin-induced gene 2 protein, INSIG2 membrane protein, insulin induced protein 2
Species: human
Products:     INSIG2

Top Publications

  1. Ciullo M, Nutile T, Dalmasso C, Sorice R, Bellenguez C, Colonna V, et al. Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento. Diabetes. 2008;57:783-90 pubmed
    ..Three additional loci linked to BMI were also detected, including the locus including the INSIG2 gene region. No evidence of association between the rs7566605 variant and BMI or obesity was found...
  2. Liu X, Li Y, Lu X, Wang L, Zhao Q, Yang W, et al. Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population. Atherosclerosis. 2010;208:421-6 pubmed publisher
    ..the common variants of genes from the SREBP2 activating-related pathway, involving SREBP2, SCAP, INSIG1 and INSIG2 genes, were associated with coronary heart disease (CHD) of Chinese Han population individually or interactively...
  3. Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, et al. No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population. Obesity (Silver Spring). 2008;16:211-5 pubmed publisher
    ..a common genetic polymorphism (rs7566605) associated with a higher BMI was found in proximity to the insulin induced protein 2 (INSIG2 ) gene, with replication in four unrelated populations living in Western countries...
  4. Zavattari P, Loche A, Civolani P, Pilia S, Moi L, Casini M, et al. An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents. Ann Hum Genet. 2010;74:381-6 pubmed publisher
    Allelic variants of a single nucleotide polymorphism (SNP), rs7566605, located approximately 10 kb upstream of the INSIG2 gene have been found in association with body weight and with other clinical features related to obesity in some ..
  5. Baylin A, Deka R, Tuitele J, Viali S, Weeks D, McGarvey S. INSIG2 variants, dietary patterns and metabolic risk in Samoa. Eur J Clin Nutr. 2013;67:101-7 pubmed publisher
    Association of insulin-induced gene 2 (INSIG2) variants with obesity has been confirmed in several but not all follow-up studies...
  6. Boes E, Kollerits B, Heid I, Hunt S, Pichler M, Paulweber B, et al. INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism. Obesity (Silver Spring). 2008;16:827-33 pubmed publisher
    A previous epidemiological study showed an association of the insulin-induced gene 2 (INSIG2) gene with BMI...
  7. Liu X, Li Y, Wang L, Zhao Q, Lu X, Huang J, et al. The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study. Thromb Haemost. 2008;100:886-92 pubmed
    ..The insulin induced gene 1 (INSIG1) and insulin induced gene 2 (INSIG2) encode two proteins which mediate feedback control of cholesterol synthesis...
  8. Wang H, Zhang H, Zhang S, Pan Y, Ma J. Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents. Biomed Environ Sci. 2008;21:528-36 pubmed publisher
    To study the association between the rs7566605 variant of INSIG2 and obesity-related phenotypes in Chinese children and adolescents. The study sample consisted of two independent cohorts of Chinese children and adolescents...
  9. Bressler J, Fornage M, Hanis C, Kao W, Lewis C, McPherson R, et al. The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet. 2009;10:56 pubmed publisher
    ..Offspring Cohort, individuals homozygous for the rs7566605 C allele located upstream of insulin-induced gene 2 (INSIG2) were reported to incur an increased risk of obesity...

More Information

Publications74

  1. Gong Y, Lee J, Brown M, Goldstein J, Ye J. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Natl Acad Sci U S A. 2006;103:6154-9 pubmed
    ..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells. ..
  2. Oki K, Yamane K, Kamei N, Asao T, Awaya T, Kohno N. The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women. Br J Nutr. 2009;101:322-7 pubmed publisher
    ..One particularly interesting single nucleotide polymorphism (SNP), rs7566605, located 10 kb upstream of INSIG2 was reported to have the strongest association with obesity among 86 604 SNP, while the relationship with ..
  3. Wang H, Zhang H, Zhang J, Wang Y, Ma J. [Association of abnormal lipid metabolism with INSIG2 gene variant in overweight and obese children]. Zhonghua Liu Xing Bing Xue Za Zhi. 2010;31:650-4 pubmed
    To study the relationship between insulin induced gene 2 (INSIG2) variant and obesity or lipid metabolism in Chinese children and adolescents. A total number of 2030 school students at the age from 7 to 18 years were selected in Beijing...
  4. Zhang J, Lin R, Wang F, Lu M, Lin R, Wang S, et al. A common polymorphism is associated with body mass index in Uyghur population. Diabetes Res Clin Pract. 2008;81:e11-3 pubmed publisher
    We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population...
  5. Hall D, Rahman T, Avery P, Keavney B. INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. BMC Med Genet. 2006;7:83 pubmed
    ..The effects of this polymorphism on body mass may be restricted to those already predisposed to at least moderate obesity as a result of environmental factors and other predisposing genotypes. ..
  6. Krapivner S, Popov S, Chernogubova E, Hellenius M, Fisher R, Hamsten A, et al. Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. J Clin Endocrinol Metab. 2008;93:1995-2001 pubmed publisher
    ..Here, we analyzed the relative significance of INSIG1 and INSIG2 in human liver and adipocyte metabolism, and defined a novel, functional polymorphism in the promoter of INSIG2 ..
  7. Le Hellard S, Theisen F, Haberhausen M, Raeder M, Fernø J, Gebhardt S, et al. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?. Mol Psychiatry. 2009;14:308-17 pubmed publisher
    ..genes involved in the SREBP activation of fatty acids and cholesterol production (SREBF1, SREBF2, SCAP, INSIG1 and INSIG2) would be strong candidate genes for interindividual variation in drug-induced weight gain...
  8. Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, Kotani K, et al. INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet. 2008;53:857-62 pubmed publisher
    The single nucleotide polymorphism (SNP) rs7566605 in the upstream region of the insulin-induced gene 2 (INSIG2) is associated with the obesity phenotype in many Caucasian populations...
  9. Reinehr T, Hinney A, Nguyen T, Hebebrand J. Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents. Diabetes. 2008;57:623-6 pubmed
    ..single nucleotide polymorphism (SNP) rs7566605, located approximately 10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese...
  10. Yang L, Wu Y, Li H, Yu Z, Li X, Liu Y, et al. Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation. Eur J Hum Genet. 2008;16:759-61 pubmed publisher
    Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study...
  11. Wiedmann S, Neureuther K, Stark K, Reinhard W, Kallmünzer B, Baessler A, et al. Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors. Obesity (Silver Spring). 2009;17:1390-5 pubmed publisher
    ..Because significant influence of a polymorphism, rs7566605, near the INSIG2 gene on BMI has been shown in the general population and in obesity cohorts, we hypothesized that this ..
  12. Tiwari A, Zai C, Meltzer H, Lieberman J, Muller D, Kennedy J. Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients. Hum Psychopharmacol. 2010;25:253-9 pubmed publisher
    ..Insulin induced gene 2 (INSIG2) mediates feedback control of lipid synthesis and polymorphisms in the gene (rs17587100, rs10490624 and rs17047764)..
  13. Orkunoglu Suer F, Gordish Dressman H, Clarkson P, Thompson P, Angelopoulos T, Gordon P, et al. INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men. BMC Med Genet. 2008;9:117 pubmed publisher
    A common SNP upstream of the INSIG2 gene, rs7566605 (g.-10,1025G>C, Chr2:118,552,255, NT_022135...
  14. Yabe D, Brown M, Goldstein J. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A. 2002;99:12753-8 pubmed publisher
    ..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations...
  15. Cha S, Koo I, Choi S, Park B, Kim K, Kim J, et al. Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations. BMC Med Genet. 2009;10:96 pubmed publisher
    While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role...
  16. Do R, Bailey S, Pare G, Montpetit A, Desbiens K, Hudson T, et al. Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels. Circ Cardiovasc Genet. 2010;3:454-61 pubmed publisher
    In a whole-genome scan, a single nucleotide polymorphism (SNP) (rs7566605) upstream of the insulin-induced gene 2 (INSIG2) was shown to influence body mass index and obesity in the Framingham Heart Study, with replication of these results ..
  17. Marvelle A, Lange L, Qin L, Adair L, Mohlke K. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes. 2008;57:1987-91 pubmed publisher
    ..We selected and genotyped 19 single nucleotide polymorphisms in 10 genes (ADRB2, ADRB3, FTO, GNB3, INSIG2, LEPR, PPARG, TNF, UCP2, and UCP3) that had been previously reported to be associated with an obesity-related ..
  18. Herbert A, Gerry N, McQueen M, Heid I, Pfeufer A, Illig T, et al. A common genetic variant is associated with adult and childhood obesity. Science. 2006;312:279-83 pubmed
    ..scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity...
  19. Yabe D, Komuro R, Liang G, Goldstein J, Brown M. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci U S A. 2003;100:3155-60 pubmed
    ..The insulin-mediated fall in Insig-2a may allow SREBP-1c to be processed, thereby allowing insulin to stimulate fatty acid synthesis, even under conditions in which hepatic cholesterol levels are elevated. ..
  20. Lyon H, Emilsson V, Hinney A, Heid I, Lasky Su J, Zhu X, et al. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007;3:e61 pubmed
    A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues...
  21. Talbert M, Langefeld C, Ziegler J, Haffner S, Norris J, Bowden D. INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study. Obesity (Silver Spring). 2009;17:1554-62 pubmed publisher
    The genome-wide association study by Herbert et al. identified the INSIG2 single-nucleotide polymorphism (SNP) rs7566605 as contributing to increased BMI in ethnically distinct cohorts...
  22. Liou Y, Bai Y, Lin E, Chen J, Chen T, Hong C, et al. Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics. Pharmacogenomics J. 2012;12:54-61 pubmed publisher
    ..In this genetic case-control study, we investigated whether the common variants in INSIG1 and INSIG2 genes were associated with MetS in schizophrenic patients treated with atypical antipsychctics...
  23. Fornage M, Papanicolaou G, Lewis C, Boerwinkle E, Siscovick D. Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. Metabolism. 2010;59:1084-91 pubmed publisher
    Insulin-induced gene 2 (INSIG2) plays an important role in the regulation of cholesterol and fatty acids synthesis...
  24. Heid I, Huth C, Loos R, Kronenberg F, Adamkova V, Anand S, et al. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?. PLoS Genet. 2009;5:e1000694 pubmed publisher
    The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent...
  25. Smith A, Cooper J, Li L, Humphries S. INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects. Int J Obes (Lond). 2007;31:1753-5 pubmed
    ..This suggests that, at the least, the true size of the effect on obesity of this SNP is likely to be considerably less than reported previously. ..
  26. Reinehr T, Hinney A, Toschke A, Hebebrand J. Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. Arch Dis Child. 2009;94:965-7 pubmed publisher
    ..The effect of two different SNP (INSIG2: rs7566605, FTO: rs9939609) was analysed on the change of weight status in a one-year lifestyle intervention among ..
  27. Vimaleswaran K, Franks P, Brage S, Sardinha L, Andersen L, Wareham N, et al. Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS). Obesity (Silver Spring). 2009;17:1453-7 pubmed publisher
    ..association study for BMI identified a polymorphism, rs7566605, 10 kb upstream of the insulin-induced gene 2 (INSIG2) transcription start site, as the most significantly associated variant in children and adults...
  28. Andreasen C, Mogensen M, Borch Johnsen K, Sandbaek A, Lauritzen T, Sørensen T, et al. Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE. 2008;3:e2872 pubmed publisher
    The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants...
  29. Kuzuya M, Ando F, Iguchi A, Shimokata H. No association between rs7566605 variant and being overweight in Japanese. Obesity (Silver Spring). 2007;15:2531-4 pubmed
    ..84 to 1.69, p = 0.325). No significant associations were observed between polymorphism and glucose or insulin levels. These results suggested no association of the rs7566605 variant with overweight in Japanese people. ..
  30. Chu X, Erdman R, Susek M, Gerst H, Derr K, Al Agha M, et al. Association of morbid obesity with FTO and INSIG2 allelic variants. Arch Surg. 2008;143:235-40; discussion 241 pubmed publisher
    ..SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations...
  31. Kumar J, Sunkishala R, Karthikeyan G, Sengupta S. The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population. Clin Genet. 2007;71:415-8 pubmed
    ..Recently, a genetic variation upstream of insulin-induced gene 2 (INSIG2) (rs7566605) has been reported to be associated with obesity in four separate cohorts...
  32. Grzes M, Sadkowski S, Rzewuska K, Szydlowski M, Switonski M. Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level. Mol Biol Rep. 2016;43:381-9 pubmed publisher
    ..was searching for polymorphisms and transcript levels of two positional and functional candidate genes, FASN and INSIG2, encoding proteins which take part in lipid metabolism...
  33. Skelding K, Gerhard G, Vlachos H, Selzer F, Kelsey S, Chu X, et al. Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent. BMC Cardiovasc Disord. 2010;10:46 pubmed publisher
    The INSIG2 gene has been implicated in cholesterol metabolism and a single nucleotide polymorphism (SNP) near INSIG2 has been shown to be associated with obesity...
  34. Liu G, Zhu H, Dong Y, Podolsky R, Treiber F, Snieder H. Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur J Epidemiol. 2011;26:463-73 pubmed publisher
    ..association (GWA) studies identified several common variants for obesity: rs9939609 in FTO, rs7566605 near INSIG2 and both rs17782313 and rs17700633 near the MC4R gene...
  35. Apalasamy Y, Moy F, Rampal S, Bulgiba A, Mohamed Z. Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays. Genet Mol Res. 2014;13:4904-10 pubmed publisher
    ..study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity...
  36. Lee J, Gong Y, Zhang X, Ye J. Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. Proc Natl Acad Sci U S A. 2006;103:4958-63 pubmed
    ..The current studies indicate that the degradation of ubiquitinated Insigs is controlled by serine residues flanking the sites of ubiquitination. ..
  37. Ali S, Al Jazrawe M, Ma H, Whetstone H, Poon R, Farr S, et al. Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage. Arthritis Rheumatol. 2016;68:127-37 pubmed publisher
    ..To investigate the effects of chondrocyte-specific sterol accumulation, we generated mice lacking Insig1 and Insig2, which are major negative regulators of cholesterol homeostasis, under Col2a1 regulatory elements...
  38. Li C, Gruidl M, Eschrich S, McCarthy S, Wang H, Alexandrow M, et al. Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. Int J Cancer. 2008;123:273-282 pubmed publisher
    Insulin-induced gene 2 (Insig2) was recently identified as a putative positive prognostic biomarker for colon cancer prognosis...
  39. Malzahn D, Müller Nurasyid M, Heid I, Wichmann H, Bickeböller H. Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. Eur J Hum Genet. 2014;22:1217-24 pubmed publisher
    ..mass index (BMI) and obesity, we focus on a common risk variant rs7566605 upstream of the insulin-induced gene 2 (INSIG2) gene and a rare protective variant rs2229616 on the melanocortin-4 receptor (MC4R) gene...
  40. Yuan F, Wang H, Tian Y, Li Q, He L, Li N, et al. Fish oil alleviated high-fat diet-induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study. Lipids Health Dis. 2016;15:20 pubmed publisher
    ..the expression levels of genes involved in fatty acid and cholesterol metabolism, such as Srebf1, Fasn, Scd1, Insig2, Cd36, Cyp7a1, Abcg5, Abcg8 and Pcsk9...
  41. Radhakrishnan A, Ikeda Y, Kwon H, Brown M, Goldstein J. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A. 2007;104:6511-8 pubmed
    ..These studies define Insigs as oxysterol-binding proteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal cells. ..
  42. Roqueta Rivera M, Esquejo R, Phelan P, Sandor K, Dániel B, Foufelle F, et al. SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation. Cell Metab. 2016;24:474-484 pubmed publisher
    ..b>INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in ..
  43. Yabe D, Xia Z, Adams C, Rawson R. Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols. Proc Natl Acad Sci U S A. 2002;99:16672-7 pubmed publisher
    ..Thus, three different point mutations, each within the sterol-sensing domain of SCAP, prevent sterol-induced binding of SCAP to insig proteins and abolish feedback regulation of SREBP processing by sterols...
  44. Kuo P, Kao C, Chen P, Chen C, Tsai Y, Lu M, et al. Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients. J Clin Psychopharmacol. 2011;31:705-11 pubmed publisher
    ..have suggested some candidate genes for obesity- and metabolic-related traits, including the insulin-induced gene (INSIG2), melanocortin 4 receptor gene (MC4R), and leptin and leptin receptor genes (LEP and LEPR)...
  45. Franks P, Jablonski K, Delahanty L, McAteer J, Kahn S, Knowler W, et al. Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia. 2008;51:2214-23 pubmed publisher
    ..and obesity associated gene (FTO) and the rs7566605 SNP located 10 kb upstream of the insulin-induced gene 2 gene (INSIG2) have been proposed as risk factors for common obesity...
  46. Pirini F, Rodriguez Torres S, Ayandibu B, Orera Clemente M, González de la Vega A, Lawson F, et al. INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program. Mol Med Rep. 2017;: pubmed publisher
    ..of the following five energy balance and lipid metabolism?associated loci: Near insulin?induced gene 2 (INSIG2); melanocortin 4 receptor; adrenoceptor ?2; apolipoprotein A5; and G?protein subunit ?3...
  47. Doecke J, Zhao Z, Stark M, Green A, Hayward N, Montgomery G, et al. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiol Biomarkers Prev. 2008;17:1007-12 pubmed publisher
    ..previously implicated in obesity pathways (LEP, LEPR, ADIPOQ, POMC, PPARalpha, PPARgamma, RXRgamma, GHRL, and INSIG2) in a large Australian case-control study comprising DNA samples from 260 EAC cases, 301 EGJAC cases, 213 ESCC ..
  48. Parikh M, Hetherington J, Sheth S, Seiler J, Ostrer H, Gerhard G, et al. Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations. Surg Obes Relat Dis. 2013;9:436-41 pubmed publisher
    ..Larger studies in more class III obese Hispanics of different nationalities are needed. ..
  49. Rodrigue Way A, Caron V, Bilodeau S, Keil S, Hassan M, Levy E, et al. Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPAR?/PGC-1? pathway and Insig1/2 expression in hepatocytes. FASEB J. 2014;28:1910-23 pubmed publisher
    ..Insig1 and Insig2 gene expression was also increased through activation of nuclear receptor peroxisome-proliferator activating ..
  50. Nguyen A, Lee S, DeBose Boyd R. Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells. J Biol Chem. 2009;284:26778-88 pubmed publisher
    ..These studies define Insigs as the minimal requirement for sterol-accelerated degradation of the membrane domain of reductase in Drosophila S2 cells. ..
  51. Liem E, Vonk J, Sauer P, van der Steege G, Oosterom E, Stolk R, et al. Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study. Am J Clin Nutr. 2010;91:321-8 pubmed publisher
    ..and logistic regression analyses to assess the influence of candidate single nucleotide polymorphisms near the INSIG2, in the FTO, and near the MC4R genes and repeated-measures analyses of available body mass index (BMI) and ..
  52. Hwang S, Nguyen A, Jo Y, Engelking L, Brugarolas J, DeBose Boyd R. Hypoxia-inducible factor 1? activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver. J Biol Chem. 2017;292:9382-9393 pubmed publisher
    ..These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia. ..
  53. Dobrosotskaya I, Goldstein J, Brown M, Rawson R. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. J Biol Chem. 2003;278:35837-43 pubmed
    ..They indicate that insect cells can respond to sterols when proper regulatory proteins are expressed. ..
  54. Tiazhka O, Minchenko D, Davydov V, Moliavko O, Budreiko O, Kulieshova D, et al. [EXPRESSION OF GENES, WHICH CONTROL GLUCOSE METABOLISM, IN BLOOD CELLS OF THE OBESE BOYS WITH INSULIN RESISTANCE]. Lik Sprava. 2015;:66-71 pubmed
    ..It was shown that the expression level of PFKFB3 gene is increased, PFKFB1 and INSIG2--is decreased, but HK2 gene--significantly does not change in the blood cells of obese boys with normal insulin ..
  55. Sun S, Zhang G, Sun Q, Wu Z, Shi W, Yang B, et al. Insulin-induced gene 2 expression correlates with colorectal cancer metastasis and disease outcome. IUBMB Life. 2016;68:65-71 pubmed publisher
    ..Hence, it is imperative to develop novel biomarkers of CRC. Insulin-induced gene 2 (INSIG2) has been previously reported to be a negative regulator of cholesterol synthesis and was recently identified as a ..
  56. Peeters A, Beckers S, Verrijken A, Mertens I, Van Gaal L, Van Hul W. Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants. Endocrine. 2009;36:103-9 pubmed publisher
    Previous studies have suggested that ENPP1, INSIG2, and PLIN may be linked with a higher risk for obesity or with increased phenotypic measures of obesity...
  57. Popadic Gacesa J, Secher N, Momcilovic M, Grujic N. Association between intramuscular fat in the arm following arm training and INSIG2. Scand J Med Sci Sports. 2014;24:907-12 pubmed publisher
    Insulin-induced gene 2 (INSIG2) single-nucleotide polymorphism (SNP rs7566605) is linked to lipid metabolism, and this study assessed its potential influence on fat in the upper arm following arm training...
  58. Su M, Tung K, Liang P, Tsai C, Kuo N, Lee Y. Gene-gene and gene-environmental interactions of childhood asthma: a multifactor dimension reduction approach. PLoS ONE. 2012;7:e30694 pubmed publisher
    ..P (GSTP1), the gene coding interleukin-4 receptor alpha chain (IL4Ra) and the gene coding insulin induced gene 2 (INSIG2) on the risk of lifetime asthma. The testing-balanced accuracy on asthma was 57...
  59. Campa D, Husing A, McKay J, Sinilnikova O, Vogel U, Tjønneland A, et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer. 2010;10:563 pubmed publisher
    The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI)...
  60. Kaulfers A, Deka R, Dolan L, Martin L. Association of INSIG2 polymorphism with overweight and LDL in children. PLoS ONE. 2015;10:e0116340 pubmed publisher
    ..A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis...
  61. Hubacek J, Kuthanova L, Bohuslavova R, Adamkova V, Lanska V, Meitinger T, et al. INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample. Folia Biol (Praha). 2010;56:131-4 pubmed
    ..Rs7566650 (G>C) single-nucleotide polymorphism (SNP) near the promoter of the INSIG2 gene has been identified as associated with body mass index...
  62. Guan L, Shang X, Liu F, Song J, Ma J, Wang H. Association of INSIG2 rs9308762 with ALT level independent of BMI. J Pediatr Gastroenterol Nutr. 2014;58:155-9 pubmed publisher
    ..in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD...
  63. Tan S, Scherag A, Janssen O, Hahn S, Lahner H, Dietz T, et al. Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet. 2010;11:12 pubmed publisher
    ..polymorphisms (SNPs) in or in proximity to the fat mass and obesity associated gene (FTO), insulin-induced gene-2 (INSIG2), transcription factor 7-like 2 gene (TCF7L2) and melanocortin 4 receptor gene (MC4R)...
  64. Fernández Alvarez A, Soledad Alvarez M, Cucarella C, Casado M. Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs. J Biol Chem. 2010;285:11765-74 pubmed publisher
    Insulin-induced gene 2 (INSIG2) and its homolog INSIG1 encode closely related endoplasmic reticulum proteins that regulate the proteolytic activation of sterol regulatory element-binding proteins, transcription factors that activate the ..
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    ..association findings and investigated the genes encoding serotonin 2C receptor (HTR2C), insulin-induced gene 2 (INSIG2) and leptin (LEP)...