Gene Symbol: INPP5F
Description: inositol polyphosphate-5-phosphatase F
Alias: MSTP007, MSTPO47, SAC2, hSAC2, phosphatidylinositide phosphatase SAC2, Sac domain-containing inositol phosphatase 2, sac domain-containing phosphoinositide 4-phosphatase 2, sac domain-containing phosphoinositide 5-phosphatase 2
Species: human
Products:     INPP5F

Top Publications

  1. Minagawa T, Ijuin T, Mochizuki Y, Takenawa T. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem. 2001;276:22011-5 pubmed
    We have characterized a novel Sac domain-containing inositol phosphatase, hSac2. It was ubiquitously expressed but especially abundant in the brain, heart, skeletal muscle, and kidney...
  2. Zhu W, Trivedi C, Zhou D, Yuan L, Lu M, Epstein J. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res. 2009;105:1240-7 pubmed publisher
    ..Another polyphoinositide phosphatase, inositol polyphosphate-5-phosphatase F (Inpp5f) has recently been implicated in regulation of cardiac hypertrophy...
  3. Hsu C, Chiou H, Chen Y, Lin K, Rood M, Hsi H. Mercury adsorption and re-emission inhibition from actual WFGD wastewater using sulfur-containing activated carbon. Environ Res. 2018;168:319-328 pubmed publisher
    ..e., SAC2) in all tested pH values, confirming that greater sulfur content associated with effective sulfur functional group (..
  4. Zou M, Li R, Wang J, Wang K, Wang Y, Li Y, et al. Association analyses of variants of SIPA1L2, MIR4697, GCH1, VPS13C, and DDRGK1 with Parkinson's disease in East Asians. Neurobiol Aging. 2018;68:159.e7-159.e14 pubmed publisher identified 6 new risk loci for Parkinson's disease (PD), which include rs10797576/SIPA1L2, rs117896735/INPP5F, rs329648/MIR4697, rs11158026/GCH1, rs2414739/VPS13C, and rs8118008/DDRGK1...
  5. Waugh M. Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme. Mol Neurobiol. 2016;53:621-630 pubmed publisher
    ..mirrored that of PTEN, another enzyme that regulates phosphoinositide levels and also PIK3AP1, MINPP1, INPP5A and INPP5F. These results indicated a reduction in copy number for a set of phosphoinositide signalling genes that co-..
  6. Johnston H, Carter M, Larrayoz M, Clarke J, Garbis S, Oscier D, et al. Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome Dysregulation. Mol Cell Proteomics. 2018;17:776-791 pubmed publisher
    ..Several other proteins (e.g. Wee1, HMOX1/2, HDAC7 and INPP5F) were identified with significant overexpression that also represent potential targets...
  7. Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel C, Nakatsu F, et al. Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. J Neurosci. 2015;35:10429-39 pubmed publisher
    ..Silencing Inpp5f (Sac2) leads to robust enhancement of axon regeneration and growth cone reformation...
  8. Wang Y, Coiera E, Runciman W, Magrabi F. Using multiclass classification to automate the identification of patient safety incident reports by type and severity. BMC Med Inform Decis Mak. 2017;17:84 pubmed publisher
    ..8-84%) but precision was poor (6.8-11.2%). High risk incidents (SAC2) were confused with medium risk incidents (SAC3)...
  9. Bai D, Zhang Y, Shen M, Sun Y, Xia Q, Zhang Y, et al. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Sci Rep. 2016;6:22068 pubmed publisher
    ..b>Inpp5f is recently found to be a negative regulator of Akt signaling, while its expression and function in diabetic heart ..

More Information


  1. Levin R, Hammond G, Balla T, De Camilli P, Fairn G, Grinstein S. Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis. Mol Biol Cell. 2017;28:128-140 pubmed publisher
    ..Soon after the phagosome seals, PtdIns4P levels drop precipitously due to the hydrolytic activity of Sac2 and phospholipase C, becoming undetectable for ∼10 min...
  2. Zhong R, Ye Z. The SAC domain-containing protein gene family in Arabidopsis. Plant Physiol. 2003;132:544-55 pubmed
    ..Moreover, the expression of the AtSAC6 gene was highly induced by salinity. These results provide a foundation for future studies on the elucidation of the cellular functions of SAC domain-containing proteins in Arabidopsis. ..
  3. Oczkowicz M, Szmatoła T, Piórkowska K, Ropka Molik K. Variant calling from RNA-seq data of the brain transcriptome of pigs and its application for allele-specific expression and imprinting analysis. Gene. 2018;641:367-375 pubmed publisher
    ..Finally, we have used these SNPs for the verification of the imprinted status of the INPP5f variant 2, LRRTM1 and HM13 genes in pigs by Sanger sequencing...
  4. Kim H, Li A, Ahn S, Song H, Zhang W. Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. Sci Rep. 2014;4:7330 pubmed publisher
    ..Here, we demonstrate that Inositol Polyphosphate-5-Phosphatase F (INPP5F), one of the polyphosphoinositide phosphatases, is differentially expressed in GSCs from glioma patients, and is ..
  5. Thole J, Vermeer J, Zhang Y, Gadella T, Nielsen E. Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. Plant Cell. 2008;20:381-95 pubmed publisher
  6. Jiang Q, Liu Z, Zhou Z, Wang L, Wang L, Yue F, et al. Transcriptional activation and translocation of ancient NOS during immune response. FASEB J. 2016;30:3527-3540 pubmed
    ..Expression levels of tyrosine-protein kinase receptor Tie-1, phosphatidylinositide phosphatase SAC2, phosphatidylinositol-4-phosphate 5-kinase type-1?, diacylglycerol kinase ?, LPS-induced TNF-? ..
  7. Palermo G, Maisel D, Barrett M, Smith H, Duchateau Nguyen G, Nguyen T, et al. Gene expression of INPP5F as an independent prognostic marker in fludarabine-based therapy of chronic lymphocytic leukemia. Blood Cancer J. 2015;5:e353 pubmed publisher
    ..using Cox regression survival analysis on the discovery set, we identified inositol polyphosphate-5-phosphatase F (INPP5F) as a prognostic factor for progression-free survival (P<0.001; hazard ratio (HR), 1...
  8. Hsu F, Hu F, Mao Y. Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. J Cell Biol. 2015;209:97-110 pubmed publisher
    ..Here, we demonstrate that the Sac1 domain-containing protein Sac2 is a PI 4-phosphatase that specifically hydrolyzes phosphatidylinositol 4-phosphate in vitro...
  9. Yuan Y, Peng W, Liu Y, Xu Z. Palmatine attenuates isoproterenol-induced pathological hypertrophy via selectively inhibiting HDAC2 in rats. Int J Immunopathol Pharmacol. 2017;30:406-412 pubmed publisher
    ..The relative expressions of ANP, BNP, HDAC2, HDAC5, KLF4, and INPP5F transcripts were determined by real-time polymerase chain reaction (PCR)...
  10. Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter S, et al. Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. J Cell Biol. 2015;209:85-95 pubmed publisher
    ..Here we show that Sac2/INPP5F is a PI4P phosphatase that colocalizes with OCRL on endocytic membranes, including vesicles formed by clathrin-..