iNOS

Summary

Gene Symbol: iNOS
Description: nitric oxide synthase 2
Alias: HEP-NOS, INOS, NOS, NOS2A, nitric oxide synthase, inducible, NOS, type II, hepatocyte NOS, inducible NO synthase, inducible NOS, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Species: human
Products:     iNOS

Top Publications

  1. Martin M, Martinez A, Mendoza J, Taxonera C, Diaz Rubio M, Fernandez Arquero M, et al. Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility. Immunogenetics. 2007;59:833-7 pubmed
    ..This is the first association analysis of polymorphisms within the NOS2A extended gene with IBD susceptibility...
  2. Shehata S, Sharma H, Mooi W, Tibboel D. Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. Cell Biochem Biophys. 2006;44:147-55 pubmed
    ..the expression pattern of NO-generating enzyme nitric-oxide synthase (NOS) (both endothelial [eNOS] and inducible [iNOS] isoforms) in the lungs of CDH patients with PH and evaluated the influence of ECMO on the expression levels of ..
  3. Pautz A, Linker K, Hubrich T, Korhonen R, Altenhöfer S, Kleinert H. The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. J Biol Chem. 2006;281:32294-302 pubmed
    Human inducible nitric oxide synthase (iNOS) expression is regulated by transcriptional and post-transcriptional mechanisms...
  4. Glynn S, Boersma B, Dorsey T, Yi M, Yfantis H, Ridnour L, et al. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest. 2010;120:3843-54 pubmed publisher
    ..Last, pathway analysis linked the tumor NOS2 gene signature to c-Myc activation. Thus, NOS2 is associated with a basal-like transcription pattern and poor survival of ER-negative patients...
  5. Pautz A, Art J, Hahn S, Nowag S, Voss C, Kleinert H. Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide. 2010;23:75-93 pubmed publisher
    Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is involved in complex immunomodulatory and antitumoral mechanisms and has been described to have multiple beneficial microbicidal, antiviral and ..
  6. Gómez L, Anaya J, Vilchez J, Cadena J, Hinojosa R, Vélez L, et al. A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis (Edinb). 2007;87:288-94 pubmed
    ..host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high ..
  7. Pautz A, Linker K, Altenhöfer S, Heil S, Schmidt N, Art J, et al. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. J Biol Chem. 2009;284:2755-66 pubmed publisher
    ..The 3'-untranslated region of the human inducible nitric-oxide synthase (iNOS) contains five AREs, which promote RNA degradation...
  8. Dahgam S, Nyberg F, Modig L, Naluai A, Olin A. Single nucleotide polymorphisms in the NOS2 and NOS3 genes are associated with exhaled nitric oxide. J Med Genet. 2012;49:200-5 pubmed publisher
    ..However, the genetic contribution of NOS polymorphisms to FENO is not fully understood...
  9. Leung T, Liu E, Li C, Chan I, Yung E, Lam C, et al. Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentration. Pediatr Pulmonol. 2006;41:649-55 pubmed
    ..949), atopy (P = 0.305), IgE sensitization to aeroallergens (P > 0.2 for all), or FeNO (P = 0.847). These findings do not support NOS2 to be a major candidate gene for asthma or IgE-mediated allergic diseases in Chinese children. ..

More Information

Publications65

  1. Mearin F, García Gonzalez M, Strunk M, Zarate N, Malagelada J, Lanas A. Association between achalasia and nitric oxide synthase gene polymorphisms. Am J Gastroenterol. 2006;101:1979-84 pubmed
    ..NOS exists in three distinct isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible isoform (iNOS). Some studies have shown that NO production is regulated by NOS polymorphisms...
  2. Korhonen R, Linker K, Pautz A, Förstermann U, Moilanen E, Kleinert H. Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. Mol Pharmacol. 2007;71:1427-34 pubmed
    Human inducible nitric-oxide synthase (iNOS) expression is regulated both at transcriptional and post-transcriptional levels. In the present study, the effect of Jun N-terminal kinase (JNK) on human iNOS expression was investigated...
  3. Canzian F, Franceschi S, Plummer M, van Doorn L, Lu Y, Gioia Patricola L, et al. Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions. Eur J Cancer Prev. 2008;17:178-83 pubmed publisher
    ..nucleotide polymorphisms (SNPs) in cyclooxygenase 1 and 2 (PTGS1 and PTGS2), inducible nitric oxide synthase (NOS2A), interferon gamma (IFNG) and its receptor (IFNGR1), and risk of gastric precancerous lesions in a Venezuelan ..
  4. Lee K, Kang D, Park S, Berndt S, Reding D, Chatterjee N, et al. Nitric oxide synthase gene polymorphisms and prostate cancer risk. Carcinogenesis. 2009;30:621-5 pubmed publisher
    ..evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>..
  5. Zhang W, He X, Ma Y, Wang H, Xia Y, Zhao Z, et al. Inducible nitric oxide synthase expression correlates with angiogenesis, lymphangiogenesis, and poor prognosis in gastric cancer patients. Hum Pathol. 2011;42:1275-82 pubmed publisher
    ..Inducible nitric oxide synthase expression may be a good biomarker for poor prognosis in gastric cancer. ..
  6. Salam M, Bastain T, Rappaport E, Islam T, Berhane K, Gauderman W, et al. Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children. Allergy. 2011;66:412-9 pubmed publisher
    ..In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine...
  7. Ferguson H, Wild C, Anderson L, Murphy S, Johnston B, Murray L, et al. Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2008;17:727-31 pubmed publisher
    ..of "prosurvival genes," including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS)...
  8. Wang S, Davis S, Cerhan J, Hartge P, Severson R, Cozen W, et al. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis. 2006;27:1828-34 pubmed
    ..Thirteen single nucleotide polymorphisms (SNPs) from 10 oxidative stress genes (AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2) were genotyped in 1172 NHL cases and 982 population-based controls from a USA ..
  9. Brennan P, Dennis S, Poller D, Quintero M, Puxeddu R, Thomas G. Inducible nitric oxide synthase: correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma. Head Neck. 2008;30:208-14 pubmed
    ..Nitric oxide (NO), primarily produced by the enzyme inducible NO synthase (iNOS), has a large number of actions in cancer biology, but no studies have investigated its possible ..
  10. Brindicci C, Kharitonov S, Ito M, Elliott M, Hogg J, Barnes P, et al. Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;181:21-30 pubmed publisher
    ..Protein and mRNA expression of nitric oxide synthase type I (neuronal NOS [nNOS]), type II (inducible NOS [iNOS]), and type III (endothelial NOS [eNOS]) were quantified by Western blotting and reverse transcription-..
  11. Holla L, Stejskalova A, Znojil V, Vasku A. Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases. Clin Exp Allergy. 2006;36:1592-601 pubmed
    ..We analysed several polymorphisms mainly in the promoter region of the inducible NO synthase (NOS2, iNOS) gene and investigated their associations with asthma and/or atopic phenotypes...
  12. Islam T, Breton C, Salam M, McConnell R, Wenten M, Gauderman W, et al. Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax. 2010;65:139-45 pubmed publisher
    Inducible nitric oxide (NO) synthase (iNOS, encoded by NOS2A) produces NO in response to environmental stimuli, which can result in nitrosative stress...
  13. Salam M, Byun H, Lurmann F, Breton C, Wang X, Eckel S, et al. Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children. J Allergy Clin Immunol. 2012;129:232-9.e1-7 pubmed publisher
    Inducible nitric oxide synthase (iNOS; encoded by nitric oxide synthase isoform 2 [NOS2]) is the major enzyme for nitric oxide synthesis in airways...
  14. Asensi V, Montes A, Valle E, Ocaña M, Astudillo A, Alvarez V, et al. The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis. Nitric Oxide. 2007;16:44-53 pubmed
    ..044). No significant differences were found for other polymorphisms of the NOS genes such as NOS3, the promoter (-786T/C), and the missense change (E298D) in exon 7, and for NOS2, the G/A ..
  15. Li C, Hu Z, Liu Z, Wang L, Gershenwald J, Lee J, et al. Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study. Cancer. 2007;109:1570-8 pubmed
    Nitric oxide (NO) is a multifunctional molecule that is produced by both neuronal NO synthase (nNOS) and inducible NO synthase (iNOS), and the expression of nNOS and iNOS is up-regulated in various cancer cells, including cutaneous ..
  16. Shen C, Wang Y, Wang W, Jou Y, Hsu H, Hsieh H, et al. Inducible nitric oxide synthase promoter polymorphism, cigarette smoking, and urothelial carcinoma risk. Urology. 2007;69:1001-6 pubmed
    Bladder carcinoma has a high inducible nitric oxide synthase (iNOS) content, and a highly polymorphic (CCTTT)n repeat in the iNOS promoter region has been identified...
  17. Barcellos L, Ramsay P, Caillier S, Sawcer S, Haines J, Schmidt S, et al. Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis. Genes Immun. 2008;9:493-500 pubmed publisher
    ..Previous evidence has implicated the nitric oxide synthase gene (NOS2A) encoding inducible NOS on chromosome 17q11 as a potential MS susceptibility gene...
  18. Kun J, Mordmuller B, Perkins D, May J, Mercereau Puijalon O, Alpers M, et al. Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis. 2001;184:330-6 pubmed
    ..Ex vivo studies showed that cells isolated from people with this polymorphism have a 7-fold higher baseline NOS activity, compared with the levels detected in cells from subjects with the wild-type gene (P=.003).
  19. Shen J, Wang R, Wang L, Xu Y, Wang X. A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer. World J Gastroenterol. 2004;10:3278-83 pubmed
    Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylori) infection occurs in humans...
  20. Liu X, Jana M, Dasgupta S, Koka S, He J, Wood C, et al. Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia. J Biol Chem. 2002;277:39312-9 pubmed
    ..undertaken to investigate the effect of the HIV-1 tat gene on the expression of inducible nitric-oxide synthase (iNOS) in human U373MG astroglial cells and primary astroglia...
  21. Nathan C, Calingasan N, Nezezon J, Ding A, Lucia M, La Perle K, et al. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. J Exp Med. 2005;202:1163-9 pubmed
    Brains from subjects who have Alzheimer's disease (AD) express inducible nitric oxide synthase (iNOS). We tested the hypothesis that iNOS contributes to AD pathogenesis...
  22. Cobbs C, Brenman J, Aldape K, Bredt D, Israel M. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res. 1995;55:727-30 pubmed
    The nitric oxide synthases (NOS) are a family of related enzymes which regulate the production of NO, a free radical gas implicated in a wide variety of biological processes...
  23. Yamaguchi K, Saito H, Oro S, Tatebe S, Ikeguchi M, Tsujitani S. Expression of inducible nitric oxide synthase is significantly correlated with expression of vascular endothelial growth factor and dendritic cell infiltration in patients with advanced gastric carcinoma. Oncology. 2005;68:471-8 pubmed
    ..The inducible form of NOS (iNOS) is one of three classes of NOS and the strongest producer of NO...
  24. Fransen K, Elander N, Söderkvist P. Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer. Cancer Lett. 2005;225:99-103 pubmed
    ..In conclusion, these results, therefore, suggest that NOS2 promoter polymorphisms have a limited effect on the onset or progression of CRC. ..
  25. Li L, Xu H. Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival. World J Gastroenterol. 2005;11:2539-44 pubmed
    To detect the presence of inducible nitric oxide synthase (iNOS), nitrotyrosine (NT) and apoptosis in gastric adenocarcinomas and their possible correlations with the clinicopathological characteristics and prognosis of gastric ..
  26. Corbett J, Sweetland M, Wang J, Lancaster J, McDaniel M. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A. 1993;90:1731-5 pubmed
  27. Wang Y, Cao Y, Wu J, Chen M, Cha X. Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53, PCNA. World J Gastroenterol. 2005;11:46-50 pubmed
    ..Inducible nitric oxide synthase (iNOS) was expressed strongly in human gastric carcinoma (81.2%)...
  28. Xu W, Charles I, Liu L, Moncada S, Emson P. Molecular cloning and structural organization of the human inducible nitric oxide synthase gene (NOS2). Biochem Biophys Res Commun. 1996;219:784-8 pubmed
    ..These results differ from the previously reported organization of the iNOS gene, where 26 exons were reported for the genomic structure of NOS2.
  29. Boutlis C, Hobbs M, Marsh R, Misukonis M, Tkachuk A, Lagog M, et al. Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. Am J Trop Med Hyg. 2003;69:569-73 pubmed
    ..no association between CCTTT repeat number and levels of plasma NO metabolites or peripheral blood mononuclear cell NOS activity in a cohort of asymptomatic malaria-exposed coastal Papua New Guineans 1-60 years old...
  30. Feng C, Wang L, Jiao L, Liu B, Zheng S, Xie X. Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features. BMC Cancer. 2002;2:8 pubmed
    ..Recent studies indicate that the inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF) and the tumor suppressor p53 are fundamental play-markers of the ..
  31. Johannesen J, Pie A, Pociot F, Kristiansen O, Karlsen A, Nerup J. Linkage of the human inducible nitric oxide synthase gene to type 1 diabetes. J Clin Endocrinol Metab. 2001;86:2792-6 pubmed
    ..of human pancreatic islets to a mixture of cytokines induces expression of the inducible nitric oxide synthase (iNOS), impairs beta-cell function, and induces apoptosis...
  32. Linker K, Pautz A, Fechir M, Hubrich T, Greeve J, Kleinert H. Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res. 2005;33:4813-27 pubmed
    ..KSRP) as a protein interacting with the 3'-untranslated region (3'-UTR) of the human inducible nitric oxide (iNOS) mRNA. Immunodepletion of KSRP enhanced iNOS 3'-UTR RNA stability in in vitro-degradation assays...
  33. Morris B, Markus A, Glenn C, Adams D, Colagiuri S, Wang L. Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. J Mol Med (Berl). 2002;80:96-104 pubmed
    Complications of diabetes have a genetic influence. Since increased inducible nitric oxide synthase (iNOS) gene ( NOS2A) expression can contribute to tissue damage, NOS2A is a worthy candidate for such a role...
  34. Kolodziejski P, Musial A, Koo J, Eissa N. Ubiquitination of inducible nitric oxide synthase is required for its degradation. Proc Natl Acad Sci U S A. 2002;99:12315-20 pubmed
    Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators. We have previously shown that iNOS is degraded through the 26S proteasome...
  35. Gonzalez Gay M, Llorca J, Sanchez E, Lopez Nevot M, Amoli M, Garcia Porrua C, et al. Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain. Rheumatology (Oxford). 2004;43:1182-5 pubmed
    To assess the influence of inducible and endothelial nitric oxide synthase (iNOS and eNOS) polymorphisms in susceptibility to rheumatoid arthritis (RA)...
  36. Tatemichi M, Sawa T, Gilibert I, Tazawa H, Katoh T, Ohshima H. Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter. Cancer Lett. 2005;217:197-202 pubmed
    ..number polymorphism of a CCTTT pentanucleotide in the promoter region of the inducible nitric oxide synthase gene (iNOS) and a polymorphism of the interleukin-1beta (IL-1B) promoter at position -31 were analyzed in DNA samples from 181 ..
  37. Burgner D, Usen S, Rockett K, Jallow M, Ackerman H, Cervino A, et al. Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria. Hum Genet. 2003;112:379-86 pubmed
    ..critical in the pathogenesis of cerebral malaria, we analysed genetic variation in the proximal promoter region of NOS2A, the gene encoding inducible nitric oxide synthase...
  38. Guo F, De Raeve H, Rice T, Stuehr D, Thunnissen F, Erzurum S. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci U S A. 1995;92:7809-13 pubmed
    ..conclusively demonstrate that NO synthesis in normal human airways is due to the continuous expression of the inducible NOS (iNOS) isoform in airway epithelial cells...
  39. Koka P, He K, Zack J, Kitchen S, Peacock W, Fried I, et al. Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med. 1995;182:941-51 pubmed
  40. Geller D, Lowenstein C, Shapiro R, Nussler A, Di Silvio M, Wang S, et al. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A. 1993;90:3491-5 pubmed
    ..We now report the molecular cloning and expression of an inducible human hepatocyte NOS (hep-NOS) cDNA. hep-NOS has 80% amino acid sequence homology to macrophage NOS (mac-NOS)...
  41. Fecker L, Eberle J, Orfanos C, Geilen C. Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide. J Invest Dermatol. 2002;118:1019-25 pubmed
  42. Fischmann T, Hruza A, Niu X, Fossetta J, Lunn C, Dolphin E, et al. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Nat Struct Biol. 1999;6:233-42 pubmed
    Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively...
  43. Hori K, Burd P, Furuke K, Kutza J, Weih K, Clouse K. Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome. Blood. 1999;93:1843-50 pubmed
    ..monocyte-derived macrophages (MDM) produce low levels of NO in vitro and that inducible nitric oxide synthase (iNOS) is expressed in the brain of patients with neurologic disease...
  44. Adamson D, Wildemann B, Sasaki M, Glass J, McArthur J, Christov V, et al. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science. 1996;274:1917-21 pubmed
    ..mediator of neuronal injury, because cytokines may activate the immunologic (type II) isoform of NO synthase (iNOS)...
  45. Kolodziejski P, Koo J, Eissa N. Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors. Proc Natl Acad Sci U S A. 2004;101:18141-6 pubmed
    Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of many disorders...
  46. Cramer J, Mockenhaupt F, Ehrhardt S, Burkhardt J, Otchwemah R, Dietz E, et al. iNOS promoter variants and severe malaria in Ghanaian children. Trop Med Int Health. 2004;9:1074-80 pubmed
    ..Polymorphisms in the inducible nitric oxide synthase promoter (iNOS; -954G-->C, -1173C-->T, -2...
  47. Park C, Pardhasaradhi K, Gianotti C, Villegas E, Krishna G. Human retina expresses both constitutive and inducible isoforms of nitric oxide synthase mRNA. Biochem Biophys Res Commun. 1994;205:85-91 pubmed
    ..showed more than 99% homology with human brain bNOS and that of riNOS was identical to the chondrocytes inducible iNOS with the exception for one amino acid...
  48. Hobbs M, Udhayakumar V, Levesque M, Booth J, Roberts J, Tkachuk A, et al. A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. Lancet. 2002;360:1468-75 pubmed
    Nitric oxide (NO) is a mediator of immunity to malaria, and genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate production of NO...
  49. Cianchi F, Cortesini C, Fantappiè O, Messerini L, Schiavone N, Vannacci A, et al. Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis. Am J Pathol. 2003;162:793-801 pubmed
    ..in colorectal carcinogenesis, we correlated the expression and the activity of inducible nitric oxide synthase (iNOS) with the degree of tumor angiogenesis in human colorectal cancer...
  50. Sherman P, Laubach V, Reep B, Wood E. Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry. 1993;32:11600-5 pubmed
    ..We have purified the enzyme and examined some of its biochemical properties. An antiserum to an inducible NOS from murine macrophages cross-reacted with the DLD-1 NOS...
  51. Halderman A, Lane A. Genetic and Immune Dysregulation in Chronic Rhinosinusitis. Otolaryngol Clin North Am. 2017;50:13-28 pubmed publisher
    ..Current evidence for a genetic basis of CRS is reviewed, as it pertains to putative abnormalities in innate and adaptive immune function. The role of systemic immunodeficiencies in refractory CRS is discussed. ..
  52. Yook J, Kim K, Kim M, Cha Y. Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice. J Med Food. 2017;20:367-375 pubmed publisher
    ..Moreover, BAB inhibited induction of nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and activation of nuclear factor-kappa B (NF-?B) in the colon...
  53. Iyaswamy A, Kammella A, Thavasimuthu C, Wankupar W, Dapkupar W, Shanmugam S, et al. Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR-CaMKII-ERK/CREB signalling on consumption of aspartame in rat model. J Food Drug Anal. 2018;26:903-916 pubmed publisher
    ..in the mRNA and protein expression of neuronal nitric oxide synthase (nNOS) and induced nitric oxide synthase (iNOS) which resulted in the increased nitric oxide radical's level indicating that aspartame is a stressor...
  54. Yan L, Chen W, Zeng S, Wang Y, Bai Z. Inhibition of VEGF expression in tongue squamous cancer cells via RNA interference silencing of iNOS gene. Int J Oral Maxillofac Surg. 2009;38:369-73 pubmed publisher
    The purpose of this study was to investigate the regulatory role of the inducible nitric oxide synthase (iNOS) gene on vascular endothelial growth factor (VEGF) expression in oral squamous cancer cells...
  55. Juarez E, Tufiño C, Querejeta E, Bracho Valdés I, Bobadilla Lugo R. Evidence of changes in alpha-1/AT1 receptor function generated by diet-induced obesity. Diab Vasc Dis Res. 2017;14:485-493 pubmed publisher
    ..II Receptor type 2 (AT2R), Cyclooxygenase-1 (COX-1), Cyclooxygenase-2 (COX-2), inducible Nitric Oxide Synthase (iNOS) and endothelial Nitric Oxide Synthase (eNOS), as well as blood pressure, glucose, insulin and angiotensin II blood ..
  56. Altinoz M, Elmaci I. Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones. Nitric Oxide. 2018;79:68-83 pubmed publisher
    ..PBN inhibits the signaling pathways of NF-?B, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)...