Gene Symbol: INHBA
Description: inhibin subunit beta A
Alias: EDF, FRP, inhibin beta A chain, FSH-releasing protein, Inhibin, beta-1, activin beta-A chain, erythroid differentiation factor, erythroid differentiation protein, follicle-stimulating hormone-releasing protein, inhibin beta A subunit, inhibin, beta A (activin A, activin AB alpha polypeptide)
Species: human
Products:     INHBA

Top Publications

  1. Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, et al. Elevated levels of activin A in heart failure: potential role in myocardial remodeling. Circulation. 2004;109:1379-85 pubmed
  2. Ueland T, Aukrust P, Aakhus S, Smith C, Endresen K, Birkeland K, et al. Activin A and cardiovascular disease in type 2 diabetes mellitus. Diab Vasc Dis Res. 2012;9:234-7 pubmed publisher
    ..In patients with T2DM, increased activin A may reflect chronic underlying pathophysiological processes involved in development of cardiovascular disease. ..
  3. Lewis K, Gray P, Blount A, MacConell L, Wiater E, Bilezikjian L, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404:411-4 pubmed
    ..The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity and function. ..
  4. Robson N, Phillips D, McAlpine T, Shin A, Svobodova S, Toy T, et al. Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production. Blood. 2008;111:2733-43 pubmed
    ..These findings establish an immune-regulatory role for activin-A in DCs, highlighting the potential of antagonizing activin-A signaling in vivo to enhance vaccine immunogenicity. ..
  5. Tsigkou A, Luisi S, De Leo V, Patton L, Gambineri A, Reis F, et al. High serum concentration of total inhibin in polycystic ovary syndrome. Fertil Steril. 2008;90:1859-63 pubmed publisher
    ..Women with PCOS have high serum concentration of total inhibin but not of inhibin A or inhibin B, thus suggesting that PCOS women have an impaired processing of alpha-inhibin precursor proteins. ..
  6. Weigert J, Neumeier M, Wanninger J, Schober F, Sporrer D, Weber M, et al. Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes. Cytokine. 2009;45:86-91 pubmed publisher
    ..These findings indicate that adiponectin upregulates monocytic activin A release via the p38 MAPK pathway, and this may in part explain the immunoregulatory and antiatherosclerotic effects of this adipokine. ..
  7. Yndestad A, Larsen K, Oie E, Ueland T, Smith C, Halvorsen B, et al. Elevated levels of activin A in clinical and experimental pulmonary hypertension. J Appl Physiol (1985). 2009;106:1356-64 pubmed publisher
    ..Our findings in both clinical and experimental studies suggest a role for activin A in the development of various types of PH. ..
  8. Prakash A, Laird S, Tuckerman E, Li T, Ledger W. Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage. Fertil Steril. 2005;83:1758-63 pubmed
    ..To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage...
  9. Miyoshi T, Hirohata S, Uesugi T, Hirota M, Ohnishi H, Nogami K, et al. Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention. Clin Chim Acta. 2009;401:3-7 pubmed publisher
    ..The serum activin A level, increased in AMI, was positively correlated with peak CK and CK-MB levels which are measures of infarction size. ..

More Information

Publications130 found, 100 shown here

  1. Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, et al. Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A. 2010;107:5124-9 pubmed publisher
    ..Targeting activin A by a soluble decoy receptor reversed osteoblast inhibition, ameliorated MM bone disease, and inhibited tumor growth in an in vivo humanized MM model, setting the stage for testing in human clinical trials. ..
  2. Andersen G, Ueland T, Knudsen E, Scholz H, Yndestad A, Sahraoui A, et al. Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation. Diabetes. 2011;60:1544-51 pubmed publisher
    ..Our in vitro findings suggest that this association represents a counteracting mechanism to protect against inflammation, hyperglycemia, and oxidative stress. ..
  3. Fournier C, Rizzoli R, Bouzakri K, Ammann P. Selective protein depletion impairs bone growth and causes liver fatty infiltration in female rats: prevention by Spirulina alga. Osteoporos Int. 2016;27:3365-3376 pubmed publisher
    ..and even led to higher biomechanical properties and lower hepatic fat content in association with specific InhbA and Follistatin expression changes vs. the 10 % casein group...
  4. Seachrist D, Sizemore S, Johnson E, Abdul Karim F, Weber Bonk K, Keri R. Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer. Breast Cancer Res. 2017;19:66 pubmed publisher
    ..Using publicly available gene expression data, we examined the expression patterns of FST and INHBA, a subunit of activin, in normal and cancerous breast tissue and the prognostic value of FST in breast cancer ..
  5. O Connell A, McNatty K, Hurst P, Spencer T, Bazer F, Reader K, et al. Activin A and follistatin during the oestrous cycle and early pregnancy in ewes. J Endocrinol. 2016;228:193-203 pubmed publisher
    ..The mRNAs encoding FST and activin A (inhibin beta A subunit; INHBA) were present in the uterus and abundant in the uterine luminal or glandular epithelia by day 18 of ..
  6. DEAN M, Davis D, Burdette J. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114-124 pubmed publisher
    ..SB431542 and follistatin, reduced migration in OVCAR4 cells, which expressed activin A subunits (encoded by INHBA). Murine superovulation increased phospho-Smad2/3 immunostaining in the FTE...
  7. Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed publisher
    ..Knockdown of endogenous INHBA repressed the expression of EGFR and inhibited activin A-mediated canonical Smads, noncanonical phosphorylation of ..
  8. Cai K, Hua G, Ahmad S, Liang A, Han L, Wu C, et al. Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice. PLoS ONE. 2011;6:e25585 pubmed publisher
    ..Inha silencing also suppressed Pdgfa, Igf1, and Kitl mRNA levels and up-regulated Tgfbrs, Inhba, Inhbb, Cyp11a1, Dhh, and Tjp1 mRNA levels (as indicated by real-time polymerase chain reaction [PCR] analysis)...
  9. Soler Palacios B, Estrada Capetillo L, Izquierdo E, Criado G, Nieto C, Municio C, et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. J Pathol. 2015;235:515-26 pubmed publisher
    ..on monocytes and macrophages indicated that RA-SF promoted the acquisition of pro-inflammatory markers (INHBA, MMP12, EGLN3, CCR2) but led to a significant reduction in the expression of genes associated with homeostasis and ..
  10. Ojima F, Saito Y, Tsuchiya Y, Ogoshi M, Fukamachi H, Inagaki K, et al. Runx3 regulates folliculogenesis and steroidogenesis in granulosa cells of immature mice. Cell Tissue Res. 2019;375:743-754 pubmed publisher
    ..The expression of genes encoding activin and inhibin subunits (Inha, Inhba and Inhbb) was also decreased in ovaries from the Runx3-/- mice compared with that in wt mice...
  11. Estienne A, Lahoz B, Jarrier P, Bodin L, Folch J, Alabart J, et al. BMP15 regulates the inhibin/activin system independently of ovulation rate control in sheep. Reproduction. 2017;153:395-404 pubmed publisher
    ..There were only small differences between mutant and wild-type ewes for mRNA expression of INHA, INHBA, ACVR1B, ACVR2A, FST or TGFBR3 in granulosa cells and inhibin A or activin A concentrations in follicular fluid...
  12. Blanco F, Ojeda Fernandez L, Aristorena M, Gallardo Vara E, Benguria A, Dopazo A, et al. Genome-wide transcriptional and functional analysis of endoglin isoforms in the human promonocytic cell line U937. J Cell Physiol. 2015;230:947-58 pubmed publisher
    ..Moreover, activin A (INHBA gene), a TGF-β superfamily member involved in macrophage polarization, was distinctly affected in each endoglin ..
  13. Ravaud C, Paré M, Azoulay S, Dani C, Ladoux A. Impairment of the activin A autocrine loop by lopinavir reduces self-renewal of distinct human adipose progenitors. Sci Rep. 2017;7:2986 pubmed publisher
    ..Expressions of the transcription factor EGR1 and its targets, including INHBA were subsequently altered...
  14. Wang S, Liu W, Pang X, Dai S, Liu G. The Mechanism of Melatonin and Its Receptor MT2 Involved in the Development of Bovine Granulosa Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>StAR, RUNX2, INHA and INHBB) were up-regulated without affecting the expression of INHBA, suggesting that MT2 silencing may regulate hormone abundance...
  15. Bryant S, Francis J, Lokody I, Wang H, Risbridger G, Loveland K, et al. Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development. Dev Biol. 2014;395:209-17 pubmed publisher
    ..development indicate that one of the roles of retinoic acid signaling in the male is to inhibit the expression of Inhba, which encodes the βA subunit of Activin, in the UGS mesenchyme...
  16. Omura T, Omura K, Tedeschi A, Riva P, Painter M, Rojas L, et al. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015;86:1215-27 pubmed publisher
    ..neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability...
  17. Lau D, Bengtson C, Buchthal B, Bading H. BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A. Cell Rep. 2015;12:1353-66 pubmed publisher
    ..synaptic NMDA-receptor/nuclear-calcium-driven adaptogenomics, leading to increased expression of inhibin β-A (inhba)...
  18. Wang Y, Bilandzic M, Ooi G, Findlay J, Stenvers K. Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling. Mol Cell Endocrinol. 2016;436:68-77 pubmed publisher
    ..The expression of Inha, Inhba, and Inhbb in TM3 cells was determined by RT-PCR and the production of the inhibin-alpha subunit was confirmed by ..
  19. Gurusinghe S, Wallace E, Lim R. The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia. Pregnancy Hypertens. 2014;4:3-6 pubmed publisher
    ..Using placental explant cultures, we determined that transcription of sFLT1, ENG and INHBA was upregulated following exposure to oxidative stress or IL-6...
  20. Wamsley J, Kumar M, Allison D, Clift S, Holzknecht C, Szymura S, et al. Activin upregulation by NF-κB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer. Cancer Res. 2015;75:426-35 pubmed publisher
    ..of all annotated and predicted secreted gene products, we find that NF-κB activity is required to upregulate INHBA/Activin, a morphogen in the TGFβ superfamily...
  21. Heo J, Choi Y, Kim H, Kim H. Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med. 2016;37:115-25 pubmed publisher
    ..and lineage‑related and differentiation stage-related genes [B4GALNT1 (GM2/GS2 synthase), inhibin, beta A (INHBA), distal-less homeobox 5 (DLX5), runt-related transcription factor 2 (RUNX2), proliferator‑activated ..
  22. Salilew Wondim D, Wang Q, Tesfaye D, Schellander K, Hoelker M, Hossain M, et al. Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. J Ovarian Res. 2015;8:24 pubmed publisher
    ..A total of 573 gene transcripts, including CPA1, CDH1, INSL3, AMH, ALDH1B1, INHBA, CYP17A1, RBP4, GAS6, GAS7 and GATA4, were activated while 430 others including HSD17B7, HSD3B6, STAR, HMGCS1, ..
  23. Leijten J, Emons J, Sticht C, Van Gool S, Decker E, Uitterlinden A, et al. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum. 2012;64:3302-12 pubmed publisher increased expression of the bone morphogenetic protein and Wnt antagonists Gremlin 1, Frizzled-related protein (FRP), and Dkk-1 at the mRNA and protein levels in articular cartilage...
  24. Nio Kobayashi J, Kudo M, Sakuragi N, Iwanaga T, Duncan W. Loss of luteotropic prostaglandin E plays an important role in the regulation of luteolysis in women. Mol Hum Reprod. 2017;23:271-281 pubmed publisher
    ..PGE, suppress PGF synthetic enzymes and down-regulate luteolytic molecules such as ?A- and ?B-inhibin subunits (INHBA and INHBB) and bone morphogenetic proteins (BMP2, BMP4 and BMP6)...
  25. Graziano M, Benito R, Planas J, Palstra A. Swimming exercise to control precocious maturation in male seabass (Dicentrarchus labrax). BMC Dev Biol. 2018;18:10 pubmed publisher
    ..erβ2), anti-mullerian hormone (amh), structural maintenance of chromosomes protein 1B (smc1β), inhibin beta A (inhba) and gonado-somal derived factor 1 (gsdf1) in exercised males as compared with the non-exercised males...
  26. Shashikumar N, Baithalu R, Bathla S, Ali S, Rawat P, Kumaresan A, et al. Global proteomic analysis of water buffalo (Bubalus bubalis) saliva at different stages of estrous cycle using high throughput mass spectrometry. Theriogenology. 2018;110:52-60 pubmed publisher
    ..NEDD8-dissociated protein 1, Heat shock 70 kDa protein 1A, 17-beta-hydroxysteroid dehydrogenase type 1, Inhibin beta A chain, testin were identified as estrus specific and are important for estrus physiology...
  27. Ismail H, Miotla Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, et al. Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis. Arthritis Rheumatol. 2016;68:1165-71 pubmed publisher
    ..These included Has1, Adamts4, Tnf, Il6, Il18, Il18rap, Il1a, Inhba, Cd68, Ngf, Ccr2, Wnt16, and Tnfaip6, but not Adamts5...
  28. Hye Kim J, Gyu Park S, Kim W, Song S, Sung J. Functional regulation of adipose-derived stem cells by PDGF-D. Stem Cells. 2015;33:542-56 pubmed publisher
    ..PDGF-D also upregulates growth factor expression in ASCs. Therefore, PDGF-D can be considered a novel ASC stimulator, and used as a preconditioning agent before ASC transplantation. ..
  29. Dai Y, Wang Q, Gonzalez Lopez A, Anders M, Malfertheiner P, Vieth M, et al. Genome-Wide Analysis of Barrett's Adenocarcinoma. A First Step Towards Identifying Patients at Risk and Developing Therapeutic Paths. Transl Oncol. 2018;11:116-124 pubmed publisher esophageal carcinomas belong to the GO groups extracellular region /matrix such as MMP1, CTHRC1, and INHBA. According to an analysis of genes strongly up-regulated in both esophageal adenocarcinoma and Barrett's esophagus,..
  30. Lebbe C, Becker J, Grob J, Malvehy J, del Marmol V, Pehamberger H, et al. Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline. Eur J Cancer. 2015;51:2396-403 pubmed publisher
    ..A collaborative group of multidisciplinary experts form the European Dermatology Forum (EDF), The European Association of Dermato-Oncology (EADO) and the European Organization of Research and Treatment of ..
  31. Katayama Y, Oshima T, Sakamaki K, Aoyama T, Sato T, Masudo K, et al. Clinical Significance of INHBA Gene Expression in Patients with Gastric Cancer who Receive Curative Resection Followed by Adjuvant S-1 Chemotherapy. In Vivo. 2017;31:565-571 pubmed
    ..However, the five-year survival remains unsatisfactory. Inhibin βA (INHBA) has been reported to be associated with cancer cell proliferation and chemoresistance...
  32. Phoulady H, Goldgof D, Hall L, Mouton P. A framework for nucleus and overlapping cytoplasm segmentation in cervical cytology extended depth of field and volume images. Comput Med Imaging Graph. 2017;59:38-49 pubmed publisher
    ..The algorithm segments nuclei and cell clumps in extended depth of field (EDF) images and uses volume images to segment overlapping cytoplasm...
  33. Zeng Z, Shaffer J, Wang X, Feingold E, Weeks D, Lee M, et al. Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. J Dent Res. 2013;92:432-7 pubmed publisher
    ..Associations of other plausible cariogenesis genes were also observed for PF-surface caries (e.g., INHBA, p value = 6.5E-6) and for SM-surface caries (e.g., CXCR1 and CXCR2, p value = 1.9E-6)...
  34. Chang W, Lin Y, Su C, Peng H, Chang Y, Lai T, et al. Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2016;76:7140-7150 pubmed
    ..Mechanistic investigations showed that manipulating levels of activin A (INHBA) could rescue or compromise the RUNX2-mediated metastatic capabilities of HNSCC cells...
  35. Lebrun J, Vale W. Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol Cell Biol. 1997;17:1682-91 pubmed
  36. El Garem Y, El Arini A, El Beheiry A, Zeid S, Comhaire F. Possible relationship between seminal plasma inhibin B and spermatogenesis in patients with azoospermia. J Androl. 2002;23:825-9 pubmed
    ..We conclude that inhibin B secretion by Sertoli cells is differentially regulated. The contribution of accessory sex glands limits the use of seminal plasma inhibin B as a marker of spermatogenesis. ..
  37. Harrington A, Morris Triggs S, Ruotolo B, Robinson C, Ohnuma S, Hyvonen M. Structural basis for the inhibition of activin signalling by follistatin. EMBO J. 2006;25:1035-45 pubmed
    ..The structure provides a detailed description of the inhibitory mechanism and gives insights into interactions of follistatin with other TGF-beta family proteins. ..
  38. Vänttinen T, Kuulasmaa T, Liu J, Voutilainen R. Expression of activin/inhibin receptor and binding protein genes and regulation of activin/inhibin peptide secretion in human adrenocortical cells. J Clin Endocrinol Metab. 2002;87:4257-63 pubmed
    ..This, together with the adrenocortical activin/ inhibin receptor and binding protein expression, suggests a physiological role for activins and inhibins in the human adrenal gland. ..
  39. Asih S, Neblett R, Mayer T, Gatchel R. Does the Length of Disability between Injury and Functional Restoration Program Entry Affect Treatment Outcomes for Patients with Chronic Disabling Occupational Musculoskeletal Disorders?. J Occup Rehabil. 2018;28:57-67 pubmed publisher
    ..length of disability (LOD), or time between injury and treatment admission, has been shown to influence FRP work outcomes. Some studies have found that shorter LOD is associated with better work outcomes...
  40. Bagaya B, Tian M, Nickel G, Vega J, Li Y, He P, et al. An in vitro Model to Mimic Selection of Replication-Competent HIV-1 Intersubtype Recombination in Dual or Superinfected Patients. J Mol Biol. 2017;429:2246-2264 pubmed publisher
    ..Here, we established a functional recombinant production (FRP) system to produce pure and functional HIV-1 intersubtype Env recombinants and utilized 454 pyrosequencing to ..
  41. Accoroni S, Totti C, Razza E, Congestri R, Campanelli A, Marini M, et al. Phosphatase activities of a microepiphytic community during a bloom of Ostreopsis cf. ovata in the northern Adriatic Sea. Water Res. 2017;120:272-279 pubmed publisher
    ..nutrient fractions revealed very high aquatic N:P values (TN:TP = 178 ± 50), very low filterable reactive P (FRP) concentrations (13 out 19 under the limits of detection) and DOP concentrations that were on average 85% of the ..
  42. Lang P, Meis S, Prochazkova L, Carvalho L, Mackay E, Woods H, et al. Phytoplankton community responses in a shallow lake following lanthanum-bentonite application. Water Res. 2016;97:55-68 pubmed publisher
    ..control site, and may suggest an ecological response to the sustained reduction in filterable reactive phosphorus (FRP) concentration following La-bentonite application...
  43. Ma Y, Shan X. Spasm and flexion-relaxation phenomenon response to large lifting load during the performance of a trunk flexion-extension exercise. BMC Musculoskelet Disord. 2017;18:505 pubmed publisher
    The flexion relaxation phenomenon (FRP) has been widely investigated. Nevertheless, no study has been reported on the FRP as well as spasm response to large lifting load...
  44. Kato M. A secreted tumor-suppressor, mac25, with activin-binding activity. Mol Med. 2000;6:126-35 pubmed
    ..mac25 exhibits homology to insulin-like growth factor-binding proteins (IGF-BPs) and to fibroblast growth factor receptor. The multi-functional nature of mac25 protein may be important for growth-suppression and/or cellular senescence. ..
  45. Lee H, Li C, Huang C, Li W, Yeh H, Ke H, et al. INHBA overexpression indicates poor prognosis in urothelial carcinoma of urinary bladder and upper tract. J Surg Oncol. 2015;111:414-22 pubmed publisher
    ..Computerizing a published transcriptomic database of UBUC (GSE31684), we identified Inhibin, Beta A (INHBA) as the most significant upregulated gene associated with tumor progression among those associated with growth ..
  46. Howley B, Hussey G, Link L, Howe P. Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells. Oncogene. 2016;35:1725-35 pubmed publisher
    ..Our data indicate that the translational upregulation of inhibin βA enhances the migration and invasion of cells that have undergone an EMT and promotes cancer progression in vivo. ..
  47. Wilson S, Blair J, Hogg K, Langlois S, von Dadelszen P, Robinson W. Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy. BMC Med Genet. 2015;16:111 pubmed publisher
    ..88 p?<?0.01). The same trend was observed between promoter DNAm and gene expression for INHBA and PAPPA, though not significant...
  48. Hassan A, Bhuiyan M. A decision support system for automatic sleep staging from EEG signals using tunable Q-factor wavelet transform and spectral features. J Neurosci Methods. 2016;271:107-18 pubmed publisher
    ..38%, 91.50%, 92.11%, 94.80%, 97.50% for 6-stage to 2-stage classification of sleep states on the benchmark Sleep-EDF data-set. In addition, its performance on DREAMS Subjects Data-set is also promising...
  49. Hashimoto O, Yamato K, Koseki T, Ohguchi M, Ishisaki A, Shoji H, et al. The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells. Cell Signal. 1998;10:743-9 pubmed
    ..These results indicate that ActRI and ActRIB are distinct from each other and that the ActRI/ActRIB expression ratio could regulate cell-cycle arrest in the G1 phase and subsequent apoptosis in HS-72 cells induced by activin A. ..
  50. Schmierer B, Schuster M, Shkumatava A, Kuchler K. Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary. J Biol Chem. 2003;278:21197-203 pubmed
  51. Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, et al. DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. Cancer Prev Res (Phila). 2010;3:190-201 pubmed publisher
    ..These data show that DNA damage and telomere malfunction can have both cell-autonomous and cell-nonautonomous consequences and can provide a novel mechanism for the propagation of tumorigenesis. ..
  52. Herson J. Strategies for dealing with fraud in clinical trials. Int J Clin Oncol. 2016;21:22-7 pubmed publisher
    ..This leads to a proposed fraud recovery plan (FRP) that would be specified before the start of a clinical trial and would indicate actions to be taken upon detecting ..
  53. Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol. 2009;29:1707-18 pubmed publisher
    ..Finally, knockdown of activin B reduces tumor growth of RCC cells in nude mice. Our data indicate that activin B is a key mediator of VHL/HIF-induced transformation in RCC. ..
  54. Tsai Z, Singh S, Yu S, Kao L, Chen B, Ho B, et al. Identification of microRNAs regulated by activin A in human embryonic stem cells. J Cell Biochem. 2010;109:93-102 pubmed publisher
    ..These findings will help elucidate the complex signaling network which maintains the self-renewal and pluripotency of hES cells. ..
  55. Hassan A, Bhuiyan M. Automated identification of sleep states from EEG signals by means of ensemble empirical mode decomposition and random under sampling boosting. Comput Methods Programs Biomed. 2017;140:201-210 pubmed publisher
    ..07%, 83.49%, 92.66%, 94.23%, and 98.15% for 6-state to 2-state classification of sleep stages on Sleep-EDF database...
  56. Stewart A, Milborrow H, Ring J, Crowther C, Forage R. Human inhibin genes. Genomic characterisation and sequencing. FEBS Lett. 1986;206:329-34 pubmed
    ..Comparison of the known inhibin gene sequences showed, in particular, that the B subunits have identical sequences in man, pigs and cattle thus demonstrating a remarkable evolutionary conservation in these genes. ..
  57. Bartholin L, Maguer Satta V, Hayette S, Martel S, Gadoux M, Corbo L, et al. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. Oncogene. 2002;21:2227-35 pubmed
    ..This observation, in conjunction with the antagonistic effect of FLRG and follistatin on activin signaling, indicates that these two proteins participate in a negative feedback loop which regulates the activin function. ..
  58. Welt C, Sidis Y, Keutmann H, Schneyer A. Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med (Maywood). 2002;227:724-52 pubmed
    ..As technology and model systems become more sophisticated in the next few years, it should become possible to test this concept directly to more clearly define the role of activin, inhibin, and FS in reproductive physiology. ..
  59. Beloglazova N, Eremin S. Design of a sensitive fluorescent polarization immunoassay for rapid screening of milk for cephalexin. Anal Bioanal Chem. 2015;407:8525-32 pubmed publisher
    ..It was found that the highest sensitivity was achieved by use of the homologous pair CET-EDF-anti-CET antibody (limit of detection (LOD) 0...
  60. Purdue M, Graubard B, Chanock S, Rubertone M, Erickson R, McGlynn K. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. Cancer Res. 2008;68:3043-8 pubmed publisher
    ..Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped...
  61. Kariyawasam H, Pegorier S, Barkans J, Xanthou G, Aizen M, Ying S, et al. Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma. J Allergy Clin Immunol. 2009;124:454-62 pubmed publisher
    ..Both TGF-beta and activin signaling pathways are activated on allergen provocation in asthma. Activin-A may contribute to resolution of inflammation. ..
  62. Ju S, Lee S, Chakkarapani S, Kim K, Yu H, Kang S. One-Shot Dual-Code Immunotargeting for Ultra-Sensitive Tumor Necrosis Factor-α Nanosensors by 3D Enhanced Dark-Field Super-Resolution Microscopy. Anal Chem. 2018;90:5100-5107 pubmed publisher
    ..of TNF-α has been developed using three-dimensional (3D) enhanced dark-field super-resolution microscopy (3D EDF-SRM) based on ultrasensitive dual-code plasmonic nanosensing...
  63. Bahathiq A, Stewart R, Wells M, Moore H, Pacey A, Ledger W. Production of activins by the human endosalpinx. J Clin Endocrinol Metab. 2002;87:5283-9 pubmed
    ..The role in postmenopausal women is less certain, but could lead to the stimulation of FSH secretion by the pituitary gland or other autocrine/paracrine function within the uterine tube. ..
  64. Kwon H, Jia S, Lan Y, Liu H, Jiang R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. J Dent Res. 2017;96:1145-1152 pubmed publisher
    ..Remarkably, mice lacking activin-?A ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit ..
  65. Sancho R, Cantalapiedra C, López Alvarez D, Gordon S, Vogel J, Catalán P, et al. Comparative plastome genomics and phylogenomics of Brachypodium: flowering time signatures, introgression and recombination in recently diverged ecotypes. New Phytol. 2017;: pubmed publisher
    ..Within B. distachyon, we detected two main lineages, a mostly Extremely Delayed Flowering (EDF+) clade and a mostly Spanish (S+) - Turkish (T+) clade, plus nine chloroplast capture and two plastid DNA (ptDNA) ..
  66. Lamba P, Fortin J, Tran S, Wang Y, Bernard D. A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription. Mol Endocrinol. 2009;23:1001-13 pubmed publisher
    ..Mutation of this site attenuated activin A induction of both the porcine and murine promoters. Collectively, the data indicate a novel role for FOXL2 in activin A-regulated Fshb transcription. ..
  67. Ottley E, Gold E. Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression. Cytokine Growth Factor Rev. 2012;23:119-25 pubmed publisher
    ..Therefore, local and genetic elements that may be responsible for this change in cellular sensitivity to activin A during cancer progression will be highlighted with a view to identifying potential diagnostic or therapeutic targets. ..
  68. Hofland J, Van Weerden W, Steenbergen J, Dits N, Jenster G, de Jong F. Activin A stimulates AKR1C3 expression and growth in human prostate cancer. Endocrinology. 2012;153:5726-34 pubmed publisher
    ..Also, expression levels of inhibin ?A- and ?B-subunits (INHBA and INHBB) and of the activin antagonist follistatin were quantitated in patient PC tissues...
  69. Tongprasert F, Srisupundit K, Luewan S, Tongsong T. Second trimester maternal serum inhibin-A in fetal anemia secondary to hemoglobin Bart's disease. J Matern Fetal Neonatal Med. 2014;27:1005-9 pubmed publisher
    ..Since inhibin-A is commonly used as a component of quadruple test; the calculated risk of Down's syndrome may be unreliable in pregnancies with fetal Hb Bart's disease or possible fetal anemia. ..
  70. Sluchanko N, Klementiev K, Shirshin E, Tsoraev G, Friedrich T, Maksimov E. The purple Trp288Ala mutant of Synechocystis OCP persistently quenches phycobilisome fluorescence and tightly interacts with FRP. Biochim Biophys Acta Bioenerg. 2017;1858:1-11 pubmed publisher
    In Cyanobacteria, the Orange Carotenoid Protein (OCP) and Fluorescence Recovery Protein (FRP) are central to the photoprotective mechanism consisting in regulated quenching of phycobilisome (PBs) fluorescence...
  71. Jeong Y, Lee J, Kim W. Modeling and Measurement of Sustained Loading and Temperature-Dependent Deformation of Carbon Fiber-Reinforced Polymer Bonded to Concrete. Materials (Basel). 2015;8:435-450 pubmed publisher
    ..The numerical model was parameterized with experiments on the concrete, FRP, and epoxy. Good correlation was seen between the numerical results and single-lap shear experiments...
  72. Mason A, Niall H, Seeburg P. Structure of two human ovarian inhibins. Biochem Biophys Res Commun. 1986;135:957-64 pubmed
  73. Abe M, Shintani Y, Eto Y, Harada K, Kosaka M, Matsumoto T. Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells. J Leukoc Biol. 2002;72:347-52 pubmed
    ..These findings suggest that activin A is potently induced in the bone marrow and may play a role in the suppression of inflammatory or immune processes. ..
  74. Murata M, Eto Y, Shibai H, Sakai M, Muramatsu M. Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Proc Natl Acad Sci U S A. 1988;85:2434-8 pubmed
    ..The protein, designated erythroid differentiation factor (EDF), was found in the culture fluid of human THP-1 cells that had been treated with phorbol 12-..
  75. Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, et al. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene. 2004;331:17-31 pubmed
    ..Differential expression of CHL2 variants was observed during myoblast and osteoblast differentiation, implying a role for this gene in these physiological processes. ..
  76. Safwat N, Ninomiya Tsuji J, Gore A, Miller W. Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression. Endocrinology. 2005;146:4814-24 pubmed publisher
    ..In conclusion, the data presented here indicate that activation of TAK1 (and probably p38-MAPK), but not Smad3, is necessary for triggering induction of oFSHbeta by activin...
  77. McLean A, D Amour K, Jones K, Krishnamoorthy M, Kulik M, Reynolds D, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25:29-38 pubmed
    ..These findings have important implications for our understanding of hESC self-renewal and early cell fate decisions. ..
  78. Seder C, Hartojo W, Lin L, Silvers A, Wang Z, Thomas D, et al. INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma. J Thorac Oncol. 2009;4:455-62 pubmed publisher
    The expression, mechanisms of regulation, and functional impact of activin (INHBA) in esophageal adenocarcinoma (EAC) have not been fully defined...
  79. Lai J, Pinas A, Syngelaki A, Poon L, Nicolaides K. Maternal serum activin-A at 30-33 weeks in the prediction of preeclampsia. J Matern Fetal Neonatal Med. 2013;26:733-7 pubmed publisher
    ..0%, at a false positive rate of 10%. Screening by maternal characteristics and activin-A at 30-33 weeks could identify half of the pregnancies that will subsequently develop PE. ..
  80. Righetti L, Edmondson V, Corradi M, Borri A. Fiberglass Grids as Sustainable Reinforcement of Historic Masonry. Materials (Basel). 2016;9: pubmed publisher
    Fiber-reinforced composite (FRP) materials have gained an increasing success, mostly for strengthening, retrofitting and repair of existing historic masonry structures and may cause a significant enhancement of the mechanical properties ..
  81. Akay E, Yilmaz C, Kocaman E, Turkmen H, Yildiz M. Monitoring Poisson's Ratio Degradation of FRP Composites under Fatigue Loading Using Biaxially Embedded FBG Sensors. Materials (Basel). 2016;9: pubmed publisher
    The significance of strain measurement is obvious for the analysis of Fiber-Reinforced Polymer (FRP) composites. Conventional strain measurement methods are sufficient for static testing in general...
  82. Munz B, Hübner G, Tretter Y, Alzheimer C, Werner S. A novel role of activin in inflammation and repair. J Endocrinol. 1999;161:187-93 pubmed
  83. Mamin A, Philippe J. Activin A decreases glucagon and arx gene expression in alpha-cell lines. Mol Endocrinol. 2007;21:259-73 pubmed
    ..We conclude that Activin A has opposite effects on alpha-cells compared with beta-cells, a finding that may have relevance during pancreatic endocrine lineage specification and physiological function of the adult islets. ..
  84. Do T, Kubba L, Antenos M, Rademaker A, Sturgis C, Woodruff T. The role of activin A and Akt/GSK signaling in ovarian tumor biology. Endocrinology. 2008;149:3809-16 pubmed publisher
    ..046). Our data are consistent with a model in which activin A may mediate ovarian oncogenesis by activating Akt and repressing GSK to stimulate cellular proliferation. ..
  85. Kuningas M, Altmäe S, Uitterlinden A, Hofman A, van Duijn C, Tiemeier H. The relationship between fertility and lifespan in humans. Age (Dordr). 2011;33:615-22 pubmed publisher
    ..0036), FSHR (p = 0.023), FST (p = 0.023), and INHBA (p = 0.021). However, none of the independent SNPs in these genes predicted mortality...
  86. Chen W, Greulich S, van der Meer R, Rijzewijk L, Lamb H, de Roos A, et al. Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes. Cardiovasc Diabetol. 2013;12:150 pubmed publisher
    ..Current Controlled Trials SRCTN53177482. ..
  87. Segerer S, Müller N, Brandt J, Kapp M, Dietl J, Reichardt H, et al. The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation. Reprod Biol Endocrinol. 2008;6:17 pubmed publisher
    ..Thus, we have identified two novel members of the TGF-beta superfamily that could promote the generation of tolerance-inducing DCs. ..
  88. Hay D, Fletcher J, Payne C, Terrace J, Gallagher R, Snoeys J, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A. 2008;105:12301-6 pubmed publisher
    ..These studies represent an important step toward the use of hESC-derived hepatocytes in high-throughput metabolic analysis of human liver function. ..
  89. Martins da Silva S, Bayne R, Cambray N, Hartley P, McNeilly A, Anderson R. Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation. Dev Biol. 2004;266:334-45 pubmed
    ..These data indicate that activin may be involved in the autocrine and paracrine regulation of germ cell proliferation in the human ovary during the crucial period of development leading up to primordial follicle formation. ..
  90. Yding Andersen C, Rosendahl M, Byskov A. Concentration of anti-Müllerian hormone and inhibin-B in relation to steroids and age in follicular fluid from small antral human follicles. J Clin Endocrinol Metab. 2008;93:2344-9 pubmed publisher
    ..The insignificant variation of the AMH concentration with age, even in prepubertal girls, suggests that AMH expression is unrelated to menstrual cycle FSH cyclicity. ..
  91. Cronin S, Greenway M, Andersen P, Hardiman O. Screening of hypoxia-inducible genes in sporadic ALS. Amyotroph Lateral Scler. 2008;9:299-305 pubmed publisher
    ..the Irish cohort. We failed to detect association of common variation across 24 candidate hypoxia-inducible angiogenic genes with SALS. ..
  92. Forrester H, Ivashkevich A, McKay M, Leong T, de Kretser D, Sprung C. Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts. PLoS ONE. 2013;8:e77119 pubmed publisher
    ..Additionally, follistatin, by its ability to neutralise the actions of activin A may be of value as an anti-fibrotic for radiation induced fibrosis. ..