INHA

Summary

Gene Symbol: INHA
Description: inhibin subunit alpha
Alias: inhibin alpha chain, A-inhibin subunit, inhibin alpha subunit
Species: human
Products:     INHA

Top Publications

  1. Mason A, Farnworth P, Sullivan J. Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A. Mol Endocrinol. 1996;10:1055-65 pubmed
    ..In contrast, cleavage of the 110K activin A precursor to the 24K form would appear to be necessary for activity. ..
  2. Schmitt J, Millar D, Pedersen J, Clark S, Venter D, Frydenberg M, et al. Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma. Mol Endocrinol. 2002;16:213-20 pubmed
    ..These data provide the first demonstration that promoter hypermethylation and LOH are associated with the inhibin alpha-subunit gene and gene locus in prostate cancer. ..
  3. Hofland J, Feelders R, van der Wal R, Kerstens M, Haak H, de Herder W, et al. Serum inhibin pro-?C is a tumor marker for adrenocortical carcinomas. Eur J Endocrinol. 2012;166:281-9 pubmed publisher
    ..0065). Inhibin pro-?C is produced by the adrenal gland. Differentiation between ADA and ACC by serum inhibin pro-?C is limited, but its levels may constitute a novel tumor marker for ACC. ..
  4. Lewis K, Gray P, Blount A, MacConell L, Wiater E, Bilezikjian L, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404:411-4 pubmed
    ..The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity and function. ..
  5. Makanji Y, Harrison C, Stanton P, Krishna R, Robertson D. Inhibin A and B in vitro bioactivities are modified by their degree of glycosylation and their affinities to betaglycan. Endocrinology. 2007;148:2309-16 pubmed
    ..It is concluded that glycosylation of Asn(302) of the alpha-subunit of inhibin A and B results in a decrease in bioactivity, and the effect on inhibin A, at least, is explained by its reduced affinity to betaglycan. ..
  6. Tsigkou A, Luisi S, De Leo V, Patton L, Gambineri A, Reis F, et al. High serum concentration of total inhibin in polycystic ovary syndrome. Fertil Steril. 2008;90:1859-63 pubmed publisher
    ..Women with PCOS have high serum concentration of total inhibin but not of inhibin A or inhibin B, thus suggesting that PCOS women have an impaired processing of alpha-inhibin precursor proteins. ..
  7. Makanji Y, Temple Smith P, Walton K, Harrison C, Robertson D. Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in vitro and in vivo. Endocrinology. 2009;150:4784-93 pubmed publisher
  8. Lappöhn R, Burger H, Bouma J, Bangah M, Krans M, de Bruijn H. Inhibin as a marker for granulosa-cell tumors. N Engl J Med. 1989;321:790-3 pubmed
    ..We conclude that granulosa-cell tumors produce inhibin. Since serum inhibin levels reflect the size of the tumor, measurements of inhibin can be used as a marker for primary as well as recurrent disease. ..
  9. Mellor S, Richards M, Pedersen J, Robertson D, Risbridger G. Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. J Clin Endocrinol Metab. 1998;83:969-75 pubmed
    ..These results demonstrate that in contrast to ovarian granulosa cell tumors, inhibin alpha gene expression is down-regulated in poorly differentiated prostate cancer. ..

More Information

Publications118 found, 100 shown here

  1. Marchetti C, Hamdane M, Mitchell V, Mayo K, Devisme L, Rigot J, et al. Immunolocalization of inhibin and activin alpha and betaB subunits and expression of corresponding messenger RNAs in the human adult testis. Biol Reprod. 2003;68:230-5 pubmed
    ..In all testes, Sertoli cells and Leydig cells showed positive immunostaining for inhibin alpha subunit and expressed inhibin alpha subunit mRNA...
  2. Risbridger G, Ball E, Wang H, Mellor S, Peehl D. Re-evaluation of inhibin alpha subunit as a tumour suppressor in prostate cancer. Mol Cell Endocrinol. 2004;225:73-6 pubmed
    ..Consistent with the tumor suppressive function of the inhibin alpha subunit in prostate cancer, we reported a loss of gene expression due to DNA hypermethylation and loss of ..
  3. Matzuk M, Finegold M, Su J, Hsueh A, Bradley A. Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature. 1992;360:313-9 pubmed
    ..Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity. ..
  4. Prakash A, Laird S, Tuckerman E, Li T, Ledger W. Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage. Fertil Steril. 2005;83:1758-63 pubmed
    ..To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage...
  5. Muttukrishna S, Jauniaux E, Greenwold N, McGarrigle H, Jivraj S, Carter S, et al. Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages. Hum Reprod. 2002;17:3072-8 pubmed
    ..The aim of this study was to investigate the changes in circulating levels and the clinical use of inhibin A, activin A and follistatin as endocrine markers of early pregnancy loss...
  6. Makanji Y, Walton K, Wilce M, Chan K, Robertson D, Harrison C. Suppression of inhibin A biological activity by alterations in the binding site for betaglycan. J Biol Chem. 2008;283:16743-51 pubmed publisher
    ..Together these results indicate that a high affinity interaction between betaglycan and residues Val(108)-Tyr(120) of the inhibin alpha-subunit mediate inhibin A biological activity. ..
  7. Nicolas N, Michel V, Bhushan S, Wahle E, Hayward S, Ludlow H, et al. Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. Sci Rep. 2017;7:42391 pubmed publisher
    ..peak activin expression during the active phase of the disease, whereas mRNA expression of the inhibin B subunits (Inha and Inhbb) and activin receptor subunits (Acvr1b and Acvr2b) were downregulated...
  8. Liu Z, Ren Y, Pangas S, Adams J, Zhou W, Castrillon D, et al. FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol. 2015;29:1006-24 pubmed publisher
    ..Inhbb and Grem1 were selectively elevated, whereas reduction of Inha provided additional evidence that activin signaling and small mothers against decapentaplegic (SMAD) 2/3 ..
  9. DEAN M, Davis D, Burdette J. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114-124 pubmed publisher
    ..and ACVR2A) were higher in serous tumors relative to the normal ovary, while inhibitors of activin A signaling (INHA and TGFB3) were lower...
  10. Kidenya B, Mshana S, Fitzgerald D, Ocheretina O. Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania. Tuberculosis (Edinb). 2018;109:97-101 pubmed publisher
    ..The mutations detected were mabA-inhA promoter region C(-15)T and katG Ser513Thr for isoniazid; rpoB His526Leu and rpoB Ser531Leu for rifampicin; embB ..
  11. Jena L, Deshmukh S, Waghmare P, Kumar S, Harinath B. Study of mechanism of interaction of truncated isoniazid-nicotinamide adenine dinucleotide adduct against multiple enzymes of Mycobacterium tuberculosis by a computational approach. Int J Mycobacteriol. 2015;4:276-83 pubmed publisher
    ..to form the truncated INH-NAD adduct and further binds and inhibits multiple enzymes of MTB, in addition to InhA, confirming that INH is an effective anti-TB drug acting at multiple enzymes...
  12. Zignol M, Cabibbe A, Dean A, Glaziou P, Alikhanova N, Ama C, et al. Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study. Lancet Infect Dis. 2018;18:675-683 pubmed publisher
    ..resistance by genetic sequencing were 91% (95% CI 87-94) for rpoB (rifampicin resistance), 86% (74-93) for katG, inhA, and fabG promoter combined (isoniazid resistance), 54% (39-68) for pncA (pyrazinamide resistance), 85% (77-91) for ..
  13. Mpagama S, Houpt E, Stroup S, Kumburu H, Gratz J, Kibiki G, et al. Application of quantitative second-line drug susceptibility testing at a multidrug-resistant tuberculosis hospital in Tanzania. BMC Infect Dis. 2013;13:432 pubmed publisher
    ..M. tuberculosis DNA was sequenced for resistance mutations in rpoB (rifampin), inhA (isoniazid, ethionamide), katG (isoniazid), embB (ethambutol), gyrA (fluoroquinolones), rrs (amikacin, kanamycin, ..
  14. Tessema B, Nabeta P, Valli E, Albertini A, Collantes J, Lan N, et al. FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance. J Clin Microbiol. 2017;55:1066-1073 pubmed publisher
    ..WGS mutation analysis revealed FLD resistance-associated mutations in the rpoB, katG, inhA, embB, embA, and pncA genes; SLD resistance in the gyrA, gyrB, rrs, <..
  15. Rosales Klintz S, Jureen P, Zalutskayae A, Skrahina A, Xu B, Hu Y, et al. Drug resistance-related mutations in multidrug-resistant Mycobacterium tuberculosis isolates from diverse geographical regions. Int J Mycobacteriol. 2012;1:124-30 pubmed publisher
    ..fluoroquinolones, the researchers investigated the presence of mutations in the rpoB gene, the katG gene, the mabA-inhA promoter region and the gyrA gene in clinical isolates of multidrug-resistant tuberculosis (MDR-TB) from Belarus, ..
  16. Hannah Shmouni F, Moraitis A, Romero V, Faucz F, Mastroyannis S, Berthon A, et al. Successful Treatment of Estrogen Excess in Primary Bilateral Macronodular Adrenocortical Hyperplasia with Leuprolide Acetate. Horm Metab Res. 2017;: pubmed publisher
    ..Targeted sequencing revealed a pathogenic PDE11A mutation, as well as variants in the ARMC5 and INHA genes...
  17. Yin Q, Jiao W, Li Q, Xu F, Li J, Sun L, et al. Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012. BMC Microbiol. 2016;16:85 pubmed publisher
    ..In addition, the proportion of drug resistant isolates in which katG, the mabA-inhA promoter, oxyR-ahpC intergenic region, rpoB, rpsL, and embB were mutated was similar in 2006 and 2012, however ..
  18. Kim M, Cha K, Hwang S, Park U, Seo S, Lee S, et al. Pectinase-treated Panax ginseng protects heat stress-induced testicular damage in rats. Reproduction. 2017;153:737-747 pubmed publisher
    ..the expression levels of antioxidant-related enzymes (GSTM5 and GPX4), spermatogenesis-related proteins (CREB1 and INHA) and sex hormone receptors (androgen receptor, luteinizing hormone receptor and follicle-stimulating hormone ..
  19. Ajbani K, Lin S, Rodrigues C, Nguyen D, Arroyo F, Kaping J, et al. Evaluation of pyrosequencing for detecting extensively drug-resistant Mycobacterium tuberculosis among clinical isolates from four high-burden countries. Antimicrob Agents Chemother. 2015;59:414-20 pubmed publisher
    ..The molecular targets included katG, the inhA promoter and the ahpC-oxyR intergenic region for isoniazid (INH) resistance; the rpoB core region for rifampin (RIF)..
  20. Pizzamiglio S, De Bortoli M, Taverna E, Signore M, Veneroni S, Cho W, et al. Expression of Iron-Related Proteins Differentiate Non-Cancerous and Cancerous Breast Tumors. Int J Mol Sci. 2017;18: pubmed publisher
    ..morphogenetic protein 6 (BMP6), cluster of differentiation 74 (CD74), transferrin receptor (TFRC), inhibin alpha (INHA), and STAT5_pY694. These findings were confirmed for STAT5, STAT3, BMP6, CD74 and INHA when adjusting for age...
  21. Zimenkov D, Kulagina E, Antonova O, Zhuravlev V, Gryadunov D. Simultaneous drug resistance detection and genotyping of Mycobacterium tuberculosis using a low-density hydrogel microarray. J Antimicrob Chemother. 2016;71:1520-31 pubmed publisher
    ..a multiplexed assay allowing the detection of 116 drug resistance-determining mutations in the rpoB, katG, inhA, ahpC, gyrA, gyrB, rrs, eis and embB genes in the Mycobacterium tuberculosis complex genome and six SNPs to ..
  22. Doroszko M, Chruściel M, Stelmaszewska J, Ślężak T, Rivero Muller A, Padzik A, et al. Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice. Cell Physiol Biochem. 2017;43:1064-1076 pubmed publisher
    ..to Lhcgr-ko, Gata4-ko C?1 cells presented decreased proliferation, increased apoptosis, decreased expression of Inha, SV40Tag and Lhcgr tumor markers, as well as up-regulated adrenal- and down-regulated sex steroid gene expression...
  23. Farnia P, Malekshahian D, Tabarsi P, Seif S, Velayati A. Molecular drug susceptibility testing against the first-line (rifampin and isoniazid) and second-line (ciprofloxacin-amikacin and kanamycin) treatment in different subtypes of Mycobacterium simiae. Int J Mycobacteriol. 2016;5 Suppl 1:S215 pubmed publisher
    ..susceptibility to rifampin, isoniazid, ciprofloxacin, amikacin, and kanamycin were evaluated using rpoB, inhA, katG, gyrA, and rrs genes, respectively. In total, 60 cases (58.33% men and 41.66% women) of M...
  24. Pérez García F, Ruiz Serrano M, López Roa P, Acosta F, Pérez Lago L, Garcia de Viedma D, et al. Diagnostic performance of Anyplex II MTB/MDR/XDR for detection of resistance to first and second line drugs in Mycobacterium tuberculosis. J Microbiol Methods. 2017;139:74-78 pubmed publisher
    ..We evaluated the ability of Anyplex to detect resistance mutations in rpoB (rifampin [RIF]), katG and inhA (isoniazid [INH]), gyrA (fluoroquinolones [FLQ]), and rrs and eis (aminoglycosides [AMG])...
  25. Kipp J, Lambert Messerlian G, Eklund E, Rodriguez G, Demczuk M, Gundogan F. Expression of transcription factors controlling alpha inhibin gene expression in placental tissues from pregnancies affected by fetal Down syndrome. Prenat Diagn. 2012;32:302-5 pubmed publisher
  26. Kim Y, Shim J, Kim B, Lee S, Lee H, Cho C, et al. Transcriptional silencing of the inhibin-? gene in human gastric carcinoma cells. Int J Oncol. 2012;41:690-700 pubmed publisher
    ..This suggests that inhibin?? may have a more general tumor suppressor activity outside the reproductive axis. ..
  27. Homorodean D, Pop C, Jodal A, Man M. The concordance between phenotypic and genotypic M. tuberculosis drug susceptibility tests results: observational study. Pneumologia. 2015;64:26-9 pubmed
    ..tuberculosis isolated strains. The specific zone mutations in rpoB, katG and inhA gene for rifampicin and isoniazid were investigated with molecular methods in 198 recently isolated unique strains ..
  28. Café Oliveira L, Muniz Sobrinho J, Viana Magno L, Oliveira Melo S, Macho A, Rios Santos F. Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes. Braz J Infect Dis. 2016;20:166-72 pubmed publisher
    ..Mutations were found at the frequency of 41.9% for katG, 25.6% for inhA, and 69.8% for rpoB genes in multidrug-resistant strains...
  29. Matviiuk T, Madacki J, Mori G, Orena B, Menendez C, Kysil A, et al. Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis. Eur J Med Chem. 2016;123:462-475 pubmed publisher
    A series of GEQ analogues bearing pyrrolidinone or pyrrolidine cores were synthesized and evaluated against InhA, essential target for Mycobacterium tuberculosis (M.tb) survival. The compounds were also evaluated against M.tb H37Rv growth...
  30. Chand A, Harrison C, Shelling A. Inhibin and premature ovarian failure. Hum Reprod Update. 2010;16:39-50 pubmed publisher
    ..A missense mutation in the inhibin alpha subunit gene (INHA G769A) is associated with POF in several populations...
  31. Carney E, Banerjee P, Ellis C, Albadine R, Sharma R, Chaux A, et al. PAX2(-)/PAX8(-)/inhibin A(+) immunoprofile in hemangioblastoma: A helpful combination in the differential diagnosis with metastatic clear cell renal cell carcinoma to the central nervous system. Am J Surg Pathol. 2011;35:262-7 pubmed publisher
    ..We propose an immunohistochemistry (IHC) panel of combination of PAX2, PAX8, and inhibin A as a helpful approach in distinguishing the 2 lesions...
  32. Lanzas F, Ioerger T, Shah H, Acosta W, Karakousis P. First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America. J Clin Microbiol. 2016;54:2498-502 pubmed publisher
    ..regions in Panama, as well as the most frequent mutations in genes conferring resistance to isoniazid (katG and inhA) and rifampin (rpoB). Our results were confirmed with the nitrate reductase assay and genomic sequencing. M...
  33. Hamze M, Ismail M, Rahmo A, Dabboussi F. Pyrosequencing for rapid detection of tuberculosis resistance to Rifampicin and Isoniazid in Syrian and Lebanese clinical isolates. Int J Mycobacteriol. 2015;4:228-32 pubmed publisher
    ..and applied to the following loci: rpoBrpoB RIF resistance-determining region, katG, the promoter regions of inhA and ahpC-oxyR intergenic region...
  34. Jo K, Yeo Y, Sung H, Kim M, Shim T. Analysis of discrepant results between the Genotype® MTBDRplus assay and an antimicrobial drug susceptibility test for isoniazid-resistant tuberculosis. Respir Med. 2017;122:12-17 pubmed publisher
    ..4%) differed from those for ADST. KatG and inhA gene sequencing analysis results were available for 23 patients...
  35. Ennassiri W, Jaouhari S, Sabouni R, Cherki W, Charof R, Filali Maltouf A, et al. Analysis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis isolates in Morocco using GenoType® MTBDRplus assay. J Glob Antimicrob Resist. 2018;12:197-201 pubmed publisher
    ..The most frequent mutations observed were rpoBS531L (67.2%) and katGS315T1/2 (66.5%). Isolates with inhA gene mutation, katG gene mutation, and dual mutations in katG and inhA had MICs ranging from 0...
  36. Zhu J, Braun E, Kohno S, Antenos M, Xu E, Cook R, et al. Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. PLoS ONE. 2010;5:e9457 pubmed publisher
    ..This phylogenomic approach presents a new way of understanding the structure-function relationships between inhibin, activin, and the larger TGFbeta superfamily. ..
  37. Claes A, Ball B, Troedsson M, Curry T, Squires E, Scoggin K. Molecular changes in the equine follicle in relation to variations in antral follicle count and anti-Müllerian hormone concentrations. Equine Vet J. 2016;48:741-748 pubmed publisher
    ..Within growing follicles, the expression of AMH, AMHR2, ESR2 and INHA in granulosa cells was positively correlated with AFC and plasma AMH concentrations...
  38. Shilpi J, Ali M, Saha S, Hasan S, Gray A, Seidel V. Molecular docking studies on InhA, MabA and PanK enzymes from Mycobacterium tuberculosis of ellagic acid derivatives from Ludwigia adscendens and Trewia nudiflora. In Silico Pharmacol. 2015;3:10 pubmed publisher
    ..tuberculosis cell wall biogenesis, namely 2-trans-enoyl-ACP reductase (InhA) and β-ketoacyl-ACP reductase (MabA), and to pantothenate kinase (PanK type I) involved in the biosynthesis of ..
  39. Gregson E, Webb R, Sheldrick E, Campbell B, Mann G, Liddell S, et al. Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles. Reproduction. 2016;151:563-75 pubmed publisher
    ..Transcripts for further components of the TGF and IGF systems (e.g. INHA, INHBA, IGF2R and IGFBP2) varied between the first- and final-wave DFs...
  40. Bollela V, Namburete E, Feliciano C, Macheque D, Harrison L, Caminero J. Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2016;20:1099-104 pubmed publisher
    Depending on the presence of mutations that determine isoniazid (INH) susceptibility (katG and inhA), Mycobacterium tuberculosis may be susceptible to high doses of INH or ethionamide (ETH)...
  41. Nimmo C, Doyle R, Burgess C, Williams R, Gorton R, McHugh T, et al. Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum. Int J Infect Dis. 2017;62:44-46 pubmed publisher
    ..Xpert MTB/RIF and Hain line probe assays identified rpoB and inhA mutations consistent with rifampicin and intermediate isoniazid resistance, and a further possible mutation ..
  42. Florio P, Ciarmela P, Luisi S, Palumbo M, Lambert Messerlian G, Severi F, et al. Pre-eclampsia with fetal growth restriction: placental and serum activin A and inhibin A levels. Gynecol Endocrinol. 2002;16:365-72 pubmed
    ..The present data suggest that the increased placental expression of inhibin subunit mRNAs is part of the mechanism leading to increased serum activin A and inhibin A levels. ..
  43. Zhang H, Bu H, Chen H, Wei B, Liu W, Guo J, et al. Comparison of immunohistochemical markers in the differential diagnosis of adrenocortical tumors: immunohistochemical analysis of adrenocortical tumors. Appl Immunohistochem Mol Morphol. 2008;16:32-9 pubmed
    ..Thus, the combinational characterization of calretinin (either by polyclonal or monoclonal antibody), inhibin alpha, and Melan-A expression is of great significance in the differential diagnosis of ACTs. ..
  44. Hanna C, Bretherick K, Liu C, Stephenson M, Robinson W. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. Hum Reprod. 2010;25:2664-71 pubmed publisher
  45. Owono Owono L, Ntie Kang F, Keita M, Megnassan E, Frecer V, Miertus S. Virtually Designed Triclosan-Based Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis and of Plasmodium falciparum. Mol Inform. 2015;34:292-307 pubmed publisher
    ..nanomolar triclosan-based inhibitors (TCLs) of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (InhA) virtually proposed by computer-assisted molecular design...
  46. Lempens P, Meehan C, Vandelannoote K, Fissette K, De Rijk P, van Deun A, et al. Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations. Sci Rep. 2018;8:3246 pubmed publisher
    ..2 mg/L) for the combination of katG Ser315Thr and inhA c-15t...
  47. Sundblad V, Chiauzzi V, Andreone L, Campo S, Charreau E, Dain L. Controversial role of inhibin alpha-subunit gene in the aetiology of premature ovarian failure. Hum Reprod. 2006;21:1154-60 pubmed
    ..Presence of this substitution in a relevant number of control subjects is herein described for the first time. Our results indicate that -16C>T and 769G>A variants in INHalpha gene may not be associated to POF disease. ..
  48. Herndon M, Law N, Donaubauer E, Kyriss B, Hunzicker Dunn M. Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells. Mol Cell Endocrinol. 2016;434:116-26 pubmed publisher
    ..The AKT target FOXO1 is reported to function primarily as a repressor of FSH genes, including Ccnd2 and Inha. Based on its broad functions in other tissues, we hypothesized that FOXO1 may regulate many more GC genes...
  49. Narkhede Y, Merget B, Wagner S, Sotriffer C. Activity-based classification circumvents affinity prediction problems for pyrrolidine carboxamide inhibitors of InhA. J Mol Graph Model. 2018;80:76-84 pubmed publisher
    ..For a data set of 44 pyrrolidine carboxamide inhibitors of the mycobacterial enoyl-ACP-reductase InhA this proved to be case, as scoring methods of various origin and complexity did not succeed in providing ..
  50. Bakuła Z, Modrzejewska M, Pennings L, Proboszcz M, Safianowska A, Bielecki J, et al. Drug Susceptibility Profiling and Genetic Determinants of Drug Resistance in Mycobacterium kansasii. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..For drug-resistant or high-MIC isolates, eight structural genes (rrl, katG, inhA, embB, rrs, rpsL, gyrA, and gyrB) and one regulatory region (embCA) ..
  51. Schulz S, Immel U, Just L, Schaller H, Gläser C, Reichert S. Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis. Hum Immunol. 2016;77:71-5 pubmed publisher
    ..CXCL3, CXCL5, CXCL6, FADD, GATA3, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL15, IL17C, IL17RA, IL4R, IL6R, IL6ST, IL7, INHA, and TYK2) with respect to the occurrence of aggressive periodontitis (AgP). In this study 15 AgP patients (53...
  52. Thee S, Garcia Prats A, Donald P, Hesseling A, Schaaf H. A review of the use of ethionamide and prothionamide in childhood tuberculosis. Tuberculosis (Edinb). 2016;97:126-36 pubmed publisher
    ..ETH and PTH are pro-drugs that, following enzymatic activation by mycobacterial EthA inhibit InhA, a target shared with isoniazid (INH), and subsequently inhibit mycolic acid synthesis of Mycobacterium ..
  53. Inturi B, Pujar G, Purohit M. Recent Advances and Structural Features of Enoyl-ACP Reductase Inhibitors of Mycobacterium tuberculosis. Arch Pharm (Weinheim). 2016;349:817-826 pubmed publisher
    Mycobacterium tuberculosis enoyl-ACP reductase (InhA) has been validated as a promising target for antitubercular agents...
  54. Srivastava S, Bimal D, Bohra K, Singh B, Ponnan P, Jain R, et al. Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole. Eur J Med Chem. 2018;150:268-281 pubmed publisher
    ..that these compounds interfere with the constitution of bacterial cell wall possibly by targeting mycobacterial InhA and DNA gyrase enzymes...
  55. Rajkhowa S, Jha A, Deka R. Anti-tubercular drug development: computational strategies to identify potential compounds. J Mol Graph Model. 2015;62:56-68 pubmed publisher
    b>InhA is an attractive target to combat tuberculosis (TB), which is targeted by many pro-drugs (isoniazid, etc.) and drugs such as triclosan...
  56. Bang B, Park J, Kim H, Shin Y, Kwon K, Kwon H, et al. Fecal Microbiota Transplantation for Refractory and Recurrent Clostridium difficile Infection: A Case Series of Nine Patients. Korean J Gastroenterol. 2017;69:226-231 pubmed publisher
    ..We conducted a chart review of patients who underwent FMT for refractory/recurrent CDI at Inha University Hospital, between March 2014 and June 2016...
  57. Li Q, Jiao W, Yin Q, Li Y, Li J, Xu F, et al. Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains. Int J Antimicrob Agents. 2017;49:757-762 pubmed publisher
    ..Drug resistance mutations were detected in rpoB, katG, inhA and oxyR-ahpC...
  58. Kumar V, Jhamb S, Sobhia M. Cell wall permeability assisted virtual screening to identify potential direct InhA inhibitors of Mycobacterium tuberculosis and their biological evaluation. J Biomol Struct Dyn. 2017;:1-17 pubmed publisher
    ..cases of isoniazid-resistance have motivated research interests toward new class of molecules known as direct InhA inhibitors...
  59. Tadesse M, Aragaw D, Dimah B, Efa F, Abdella K, Kebede W, et al. Drug resistance-conferring mutations in Mycobacterium tuberculosis from pulmonary tuberculosis patients in Southwest Ethiopia. Int J Mycobacteriol. 2016;5:185-91 pubmed publisher
    ..8% (36/41) had mutations in the katG gene at Ser315Thr1 and 9.8% (4/41) had mutations in the inhA gene at C15T. Mutations in inhA promoter region were strongly associated with INH monoresistance...
  60. Spinato J, Boivin É, Bélanger Trudelle É, Fauchon H, Tremblay C, Soualhine H. Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012. BMC Microbiol. 2016;16:164 pubmed publisher
    ..2 %), the -15 C/T mutation in the inhA promoter (29 %); the S531L substitution in rpoB (43 %); the deletion 8 bp 446 / + R140S in pncA (72...
  61. Maurya A, Nag V, Kant S, Kushwaha R, Dhole T. Genotypic analysis of multidrug-resistant tuberculosis isolates from extra pulmonary tuberculosis cases in tertiary care centers in Northern India. Int J Mycobacteriol. 2016;5 Suppl 1:S125-S126 pubmed publisher
    ..05). The prevalence (13.4%) of MDR-TB among EPTB was high, and the most prominent mutations in rpoB, katG, and inhA genes were S531L (67.3%), S315T1 (94.5%), and C15T (20%), respectively...
  62. Amaroju S, Srinivasarao S, Napiórkowska A, Augustynowicz Kopec E, Alvala M, Lherbet C, et al. Design, synthesis of 9H-fluorenone based 1,2,3-triazole analogues as Mycobacterium tuberculosis InhA inhibitors. Chem Biol Drug Des. 2017;: pubmed publisher
    ..210 and Spec. 192 and MIC50 was determined. Further, the compounds were evaluated for MTB InhA inhibition study as well. The final analogues exhibited minimum inhibitory concentration (MIC) ranging from 52...
  63. Galarza M, Fasabi M, Levano K, Castillo E, Barreda N, Rodriguez M, et al. High-resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates. BMC Infect Dis. 2016;16:260 pubmed publisher
    ..Melting (HRM) assay in Peruvian isolates for the detection of mutations within rpoB, katG genes and promoter region inhA to determine isoniazid and rifampicin resistance in Mycobacterium tuberculosis (Mtb)...
  64. Xu J, McKeehan K, Matsuzaki K, McKeehan W. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 1995;270:6308-13 pubmed
    ..The results suggest that inhibin may be a natural antagonist of assembly of the heterodimeric activin receptor complex through a dominant-negative mechanism. ..
  65. Nicks K, Perrien D, Akel N, Suva L, Gaddy D. Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin. Mol Cell Endocrinol. 2009;310:11-20 pubmed publisher
    ..This fundamental action has the potential to de-repress locally stimulated changes in osteoblastogenesis and osteoclastogenesis, thereby altering bone metabolism. ..
  66. Tongprasert F, Srisupundit K, Luewan S, Tongsong T. Second trimester maternal serum inhibin-A in fetal anemia secondary to hemoglobin Bart's disease. J Matern Fetal Neonatal Med. 2014;27:1005-9 pubmed publisher
    ..Since inhibin-A is commonly used as a component of quadruple test; the calculated risk of Down's syndrome may be unreliable in pregnancies with fetal Hb Bart's disease or possible fetal anemia. ..
  67. Anthwal D, Gupta R, Bhalla M, Bhatnagar S, Tyagi J, Haldar S. Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis. J Clin Microbiol. 2017;55:1755-1766 pubmed publisher
    ..the most frequently observed mutations in the resistance-determining regions of rpoB, katG, and an inhA promoter and used as positive controls in HRM. The assay was first validated in 25 MDR M...
  68. Christofolini D, Cordts E, Santos Pinheiro F, Kayaki E, Dornas M, Santos M, et al. How polymorphic markers contribute to genetic diseases in different populations? The study of inhibin A for premature ovarian insufficiency. Einstein (Sao Paulo). 2017;15:269-272 pubmed publisher
    To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls...
  69. Riester S, Lin Y, Wang W, Cong L, Ali A, Peck S, et al. RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues. J Orthop Res. 2017;: pubmed publisher
    ..with the transforming growth signaling cascade, including transforming factor alpha (TGFA), inhibin alpha (INHA), inhibin beta A (INHBA), bone morphogenetic proteins (BMP2, BMP6), and others...
  70. Cho S, Yao Z, Wang S, Alban R, Barbers R, French S, et al. Regulation of activin A expression in mast cells and asthma: its effect on the proliferation of human airway smooth muscle cells. J Immunol. 2003;170:4045-52 pubmed
    ..Taken together, these data suggest that MC-derived activin A may play an important role in the process of airway remodeling by promoting the proliferation of airway smooth muscle. ..
  71. Hauzman E, Fancsovits P, Murber A, Rabe T, Strowitzki T, Papp Z, et al. Luteal-phase inhibin A and follicular-phase inhibin B levels are not characteristic of patients with an elevated LH-to-FSH ratio. J Assist Reprod Genet. 2006;23:141-7 pubmed
    ..Opposite correlations with LH and BMI suggest dysregulation of inhibin secretion rather than dimeric inhibins having a central role to the endocrinological imbalance observed in polycystic ovary syndrome. ..
  72. Balanathan P, Williams E, Wang H, Pedersen J, Horvath L, Achen M, et al. Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer. Br J Cancer. 2009;100:1784-93 pubmed publisher
    ..Our results also suggest that INH alpha expression in the primary prostate tumour can be used as a predictive factor for prognosis of PCa. ..
  73. Perrien D, Nicks K, Liu L, Akel N, Bacon A, Skinner R, et al. Inhibin A enhances bone formation during distraction osteogenesis. J Orthop Res. 2012;30:288-95 pubmed publisher
    ..This mechanism is consistent with the effects of other agents and pathologies that modulate bone formation during DO, and demonstrates the potential of hInhA to enhance bone repair and regeneration. ..
  74. Zhu J, Lin S, Zou C, Makanji Y, Jardetzky T, Woodruff T. Inhibin ?-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling. J Biol Chem. 2012;287:8060-70 pubmed publisher
  75. Janardhan S, John L, Prasanthi M, Poroikov V, Narahari Sastry G. A QSAR and molecular modelling study towards new lead finding: polypharmacological approach to Mycobacterium tuberculosis. SAR QSAR Environ Res. 2017;28:815-832 pubmed publisher
    ..A combination of pharmacophore and QSAR based virtual screening strategy taking three key targets such as InhA (enoyl-acyl-carrier-protein reductase), GlmU (N-acetyl-glucosamine-1-phosphate uridyltransferase) and DapB (..
  76. Burger H, Igarashi M. Inhibin: definition and nomenclature, including related substances. Endocrinology. 1988;122:1701-2 pubmed
  77. Lone M, Athar M, Gupta V, Jha P. Identification of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors: A combined in-silico and in-vitro analysis. J Mol Graph Model. 2017;76:172-180 pubmed publisher
    ..The current work on NADH-dependent enoyl-acyl carrier protein reductase (InhA) has yielded top scored pharmacophore models which were searched over SPECS natural product database to prioritize ..
  78. Shelling A, Burton K, Chand A, Van Ee C, France J, Farquhar C, et al. Inhibin: a candidate gene for premature ovarian failure. Hum Reprod. 2000;15:2644-9 pubmed
    ..7%) (Fisher's exact test, P < 0.035). Further analysis of the inhibin gene in POF patients and matched controls will determine its role in the aetiology of POF. ..
  79. Woad K, Pearson S, Harris S, Gersak K, Shelling A. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. Fertil Steril. 2009;91:62-6 pubmed publisher
    To determine whether variants in the promoter region of the inhibin alpha gene (INHA) are associated with premature ovarian failure (POF). Mutational analysis of the INHA gene promoter in women with POF. Academic institution...
  80. Lin H, Perng C, Lai Y, Lin F, Chiang C, Lin H, et al. Molecular screening of multidrug-resistance tuberculosis by a designated public health laboratory in Taiwan. Eur J Clin Microbiol Infect Dis. 2017;36:2431-2439 pubmed publisher
    ..The MDR-TB contact group also had a higher rate of inhA C15T mutation, banding pattern: inhA WT1(-), and inhA MUT1(+) than the recurrent group...
  81. Zhao J, Zhao J, Xu G, Wang Z, Gao J, Cui S, et al. Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice. Biol Reprod. 2017;97:497-513 pubmed publisher
    ..Our data revealed the impact of SPATA2 on male fertility and suggested that SPATA2 ensures the normal secretory function of Sertoli cells. ..
  82. McNeil M, Dennison D, Shelton C, Flint L, Korkegian A, Parish T. Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA. Tuberculosis (Edinb). 2017;107:133-136 pubmed publisher
    Isoniazid inhibits Mycobacterium tuberculosis InhA and is a key component of drug regimens that treat tuberculosis...
  83. Leung K, Siu G, Tam K, To S, Rajwani R, Ho P, et al. Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing. Front Cell Infect Microbiol. 2017;7:478 pubmed publisher
    ..However, although both strains carried identical missense mutations at rpoB S531L, inhA C-15T, and embB M306V, MYCOTB Sensititre assay showed that the post-treatment strain had 16-, 8-, and 4-..
  84. Dixit H, Deendayal M, Singh L. Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure. Hum Reprod. 2004;19:1760-4 pubmed
    ..001) with complete absence of this mutation in controls (none out of 100). The INHalpha gene is a strong candidate gene for ovarian failure. Mutations in INHbetaB and INHbetaA genes are not associated with ovarian failure. ..
  85. Jung S, Kuo T. Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma. Mod Pathol. 2005;18:788-94 pubmed
    ..In conclusion, in addition to the immunostaining of inhibin A, CD10 is a superior marker for distinguishing between a hemangioblastoma and a metastatic clear cell renal cell carcinoma. ..
  86. Pu D, Xing Y, Gao Y, Gu L, Wu J. Gene variation and premature ovarian failure: a meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2014;182:226-37 pubmed publisher
    ..788insTCT and 852C>T), ESR1 (-351A>G and -397C>T), FMR1 CGG repeat, FSHR (919A>G and 2039A>G), INHA (-16C>T and -124A>G)] and two mutations (BMP15 538G>A and INHA 769G>A)...
  87. Knudson S, Cummings J, Bommineni G, Pan P, Tonge P, Slayden R. Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis. Tuberculosis (Edinb). 2016;101:8-14 pubmed publisher
    ..develop substituted diphenyl ethers with potency against the Mycobacterium tuberculosis (Mtb) enoyl-ACP reductase (InhA), however, the highly lipophilic centroid compound, SB-PT004, lacked sufficient efficacy in the acute murine Mtb ..
  88. Wijayarathna R, de Kretser D, Meinhardt A, Middendorff R, Ludlow H, Groome N, et al. Activin over-expression in the testis of mice lacking the inhibin ?-subunit gene is associated with androgen deficiency and regression of the male reproductive tract. Mol Cell Endocrinol. 2018;470:188-198 pubmed publisher
    ..follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin ?-subunit (Inha-/-)...
  89. Barton D, Yang Feng T, Mason A, Seeburg P, Francke U. Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. Genomics. 1989;5:91-9 pubmed
    ..The possibility that the mutation in jsd involves the INH alpha or INH beta B gene was investigated by Southern blotting of DNA from jsd/jsd mice, and no major deletions or rearrangements were detected. ..
  90. Auge A, Longui C, Almeida Prado R, Rocha M, Neves M, Hirota A, et al. Abnormal inhibin A and inhibin B secretion in obese women with and without insulin resistance. Gynecol Endocrinol. 2005;21:7-11 pubmed
    ..In obese women, the percentage increase of inhibin A can represent an additional marker to recognize follicle luteinization. ..
  91. Luisi S, Borges L, Lazzeri L, Dell Anna A, Severi F, Petraglia F. Vaginally administered estroprogestinic decreases serum inhibin A and inhibin B levels and reduces endometrial thickness. Fertil Steril. 2006;86:1483-7 pubmed
    ..The present findings showed that treatment with vaginal estroprogestinic decreases serum inhibin A and inhibin B levels, the follicular diameter, and endometrial thickness, showing a rapid and significant effect with the vaginal route. ..
  92. Purdue M, Graubard B, Chanock S, Rubertone M, Erickson R, McGlynn K. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. Cancer Res. 2008;68:3043-8 pubmed publisher
    Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors...