ING2

Summary

Gene Symbol: ING2
Description: inhibitor of growth family member 2
Alias: ING1L, p33ING2, inhibitor of growth protein 2, ING1Lp, inhibitor of growth 1-like protein, p32
Species: human
Products:     ING2

Top Publications

  1. Huang W, Zhang H, Davrazou F, Kutateladze T, Shi X, Gozani O, et al. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. J Am Chem Soc. 2007;129:6498-506 pubmed
    The interaction of PtdIns(5)P with the tumor suppressor protein ING2 has been implicated in the regulation of chromatin modification...
  2. Shi X, Hong T, Walter K, Ewalt M, Michishita E, Hung T, et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006;442:96-9 pubmed
    ..The ING PHD domains are specific and highly robust binding modules for H3K4me3 and H3K4me2. ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the ..
  3. Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke S, Pedeux R, et al. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A. 2001;98:9671-6 pubmed
    ..We cloned an additional ING family member, p33ING2/ING1L. Unlike p33ING1b, p33ING2 is induced by the DNA-damaging agents etoposide and neocarzinostatin...
  4. Bua D, Martin G, Binda O, Gozani O. Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Sci Rep. 2013;3:2137 pubmed publisher
    b>ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression...
  5. Wang J, Chin M, Li G. The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Cancer Res. 2006;66:1906-11 pubmed
    b>p33ING2 is a novel candidate tumor suppressor, which has been shown to be involved in the regulation of gene transcription, cell cycle arrest, and apoptosis in a p53-dependent manner for maintaining the genomic stability...
  6. Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, et al. ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. Int J Cancer. 2009;125:1306-15 pubmed publisher
    Inhibitor of growth 2 (ING2) is associated with chromatin remodeling and regulation of gene expression by binding to a methylated histone H3K4 residue and recruiting HDAC complexes to the region...
  7. Pedeux R, Sengupta S, Shen J, Demidov O, Saito S, Onogi H, et al. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol. 2005;25:6639-48 pubmed
    b>ING2 is a candidate tumor suppressor gene that can activate p53 by enhancing its acetylation. Here, we demonstrate that ING2 is also involved in p53-mediated replicative senescence...
  8. Kumamoto K, Spillare E, Fujita K, Horikawa I, Yamashita T, Appella E, et al. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res. 2008;68:3193-203 pubmed publisher
    ..been shown to be downstream effectors of p53-mediated senescence, were up-regulated, and inhibitor of growth 2 (ING2) expression was suppressed by nutlin-3a treatment...
  9. Sironi E, Cerri A, Tomasini D, Sirchia S, Porta G, Rossella F, et al. Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. J Cutan Pathol. 2004;31:318-22 pubmed
    ..Further analyses indicate that the minimal deleted region in 4q32-35 includes p33ING2/ING1L and SAP30, whose deletion could impair the G1-phase checkpoint control and favor gene silencing, ..

More Information

Publications52

  1. Gozani O, Karuman P, Jones D, Ivanov D, Cha J, Lugovskoy A, et al. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003;114:99-111 pubmed
    ..Here, we show that ING2, a candidate tumor suppressor protein, is a nuclear PtdInsP receptor...
  2. Binda O, Nassif C, Branton P. SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins. Oncogene. 2008;27:3384-92 pubmed publisher
    ..In vitro and in vivo binding studies indicated that the p33(ING1b) and p33(ING2) subunits of the mSIN3A/HDAC1 complex are responsible for the recruitment of SIRT1 to the R2 domain...
  3. Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. Cytogenet Cell Genet. 1998;83:232-5 pubmed
    ..We have isolated a novel human gene, ING1L, that potentially encodes a PHD-type zinc-finger protein highly homologous to p33(ING1)...
  4. Chin M, Ng K, Li G. The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. Exp Cell Res. 2005;304:531-43 pubmed
    The roles of p33ING2 as a tumor suppressor candidate have been shown through regulation of gene transcription, induction of cell cycle arrest, and apoptosis. As p33ING2 shares 58...
  5. Saito M, Kumamoto K, Robles A, Horikawa I, Furusato B, Okamura S, et al. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS ONE. 2010;5:e15541 pubmed publisher
    b>ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors...
  6. Ohkouchi C, Kumamoto K, Saito M, Ishigame T, Suzuki S, Takenoshita S, et al. ING2, a tumor associated gene, enhances PAI?1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C?terminal. Mol Med Rep. 2017;16:7367-7374 pubmed publisher
    Inhibitor of growth 2 (ING2) is involved in chromatin remodeling and it has previously been suggested that ING2 may regulate gene expression...
  7. McClurg U, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, et al. Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. Br J Cancer. 2018;118:713-726 pubmed publisher
    Although the founding members of the INhibitor of Growth (ING) family of histone mark readers, ING1 and ING2, were defined as tumour suppressors in animal models, the role of other ING proteins in cellular proliferation and cancer ..
  8. Sardiu M, Smith K, Groppe B, Gilmore J, Saraf A, Egidy R, et al. Suberoylanilide hydroxamic acid (SAHA)-induced dynamics of a human histone deacetylase protein interaction network. Mol Cell Proteomics. 2014;13:3114-25 pubmed publisher
    ..A comparison of the effect of SAHA treatment on gene expression in breast cancer cells to a knockdown of the ING2 subunit indicated that a portion of the anticancer effects of SAHA may be attributed to the disruption of ING2's ..
  9. Tomazetto G, Hahnke S, Maus I, Wibberg D, Pühler A, Schlüter A, et al. Complete genome sequence of Peptoniphilus sp. strain ING2-D1G isolated from a mesophilic lab-scale completely stirred tank reactor utilizing maize silage in co-digestion with pig and cattle manure for biomethanation. J Biotechnol. 2014;192 Pt A:59-61 pubmed publisher
    The bacterium Peptoniphilus sp. strain ING2-D1G (DSM 28672), a mesophilic and obligate anaerobic bacterium belonging to the order Clostridiales was isolated from a biogas-producing lab-scale completely stirred tank reactor (CSTR) ..
  10. Hahnke S, Maus I, Wibberg D, Tomazetto G, Pühler A, Klocke M, et al. Complete genome sequence of the novel Porphyromonadaceae bacterium strain ING2-E5B isolated from a mesophilic lab-scale biogas reactor. J Biotechnol. 2015;193:34-6 pubmed publisher
    In this study, the whole genome sequence of the mesophilic, anaerobic Porphyromonadaceae bacterium strain ING2-E5B (LMG 28429, DSM 28696) is reported...
  11. Zhou L, Wang P, Zhang J, Heng B, Tong G. ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development. Zygote. 2016;24:89-97 pubmed publisher
    b>ING2 (inhibitor of growth protein-2) is a member of the ING-gene family and participates in diverse cellular processes involving tumor suppression, DNA repair, cell cycle regulation, and cellular senescence...
  12. Gao Y, Ma H, Gao C, Lv Y, Chen X, Xu R, et al. Tumor-promoting properties of miR-8084 in breast cancer through enhancing proliferation, suppressing apoptosis and inducing epithelial-mesenchymal transition. J Transl Med. 2018;16:38 pubmed publisher
    ..miR-8084 also enhances migration and invasion by inducing EMT. Moreover, the tumor suppressor ING2 is a potential target of miR-8084, and miR-8084 regulatory axes contribute to pro-tumor effect, at least partially ..
  13. Tomazetto G, Hahnke S, Langer T, Wibberg D, Blom J, Maus I, et al. The completely annotated genome and comparative genomics of the Peptoniphilaceae bacterium str. ING2-D1G, a novel acidogenic bacterium isolated from a mesophilic biogas reactor. J Biotechnol. 2017;257:178-186 pubmed publisher
    The strictly anaerobic Peptoniphilaceae bacterium str. ING2-D1G (=DSM 28672=LMG 28300) was isolated from a mesophilic laboratory-scale completely stirred tank biogas reactor (CSTR) continuously co-digesting maize silage, pig and cattle ..
  14. Zhang R, Jin J, Shi J, Hou Y. INGs are potential drug targets for cancer. J Cancer Res Clin Oncol. 2017;143:189-197 pubmed publisher
    The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors...
  15. Borkosky S, Gunduz M, Nagatsuka H, Beder L, Gunduz E, Ali M, et al. Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma. J Cancer Res Clin Oncol. 2009;135:703-13 pubmed publisher
    ..LOH) in the ING family members has been shown in head and neck squamous cell carcinoma (HNSCC) except for ING2. Like all the other members of ING family, ING2, which is located at chromosome 4q35...
  16. Kaadige M, Ayer D. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. J Biol Chem. 2006;281:28831-6 pubmed
    ..The precise function of PHD domains is currently unknown; however, the PHD domains of the ING1 and ING2 tumor suppressors have been shown recently to bind phosphoinositides (PIs)...
  17. Temel M, Turkmen A, Dokuyucu R, Cevik C, Oztuzcu S, Cengiz B, et al. A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. Tumour Biol. 2015;36:4611-6 pubmed publisher
    ..It has been thought that deletions in the ING2 gene located in the same region can play a role in the pathophysiology of BCC and that deletions occurring in this ..
  18. Zhao S, Yang X, Gou W, Lu H, Li H, Zhu Z, et al. Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis. Mol Med Rep. 2016;13:1881-7 pubmed publisher
    b>Inhibitor of growth protein 2 (ING2) has an important role in the regulation of chromatin remodeling, cell proliferation, cell‑cycle arrest, senescence and apoptosis...
  19. Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling. J Mol Med (Berl). 2016;94:1167-1179 pubmed
    ..Inhibitor of growth 1 (ING1) and ING2 are tumor suppressors with reduced expression in many cancer types...
  20. Larrieu D, Ythier D, Brambilla C, Pedeux R. ING2 controls the G1 to S-phase transition by regulating p21 expression. Cell Cycle. 2010;9:3984-90 pubmed
    b>ING2 (Inhibitor of Growth 2) is a candidate tumor suppressive protein frequently lost in human tumors. Recently, we have reported that ING2 downregulation impairs DNA replication forks progression and leads to genome instability...
  21. Ythier D, Larrieu D, Binet R, Binda O, Brambilla C, Gazzeri S, et al. Sumoylation of ING2 regulates the transcription mediated by Sin3A. Oncogene. 2010;29:5946-56 pubmed publisher
    b>ING2 (inhibitor of growth 2) is a candidate tumor-suppressor gene involved in cell cycle control, apoptosis and senescence...
  22. Nie J, Liu L, Wu M, Xing G, He S, Yin Y, et al. HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation. FEBS Lett. 2010;584:3005-12 pubmed publisher
    Inhibitor of growth 2 (ING2) gene encodes a candidate tumor suppressor and is frequently reduced in many tumors. However, the mechanisms underlying the regulation of ING2, in particular its protein stability, are still unclear...
  23. He G, Helbing C, Wagner M, Sensen C, Riabowol K. Phylogenetic analysis of the ING family of PHD finger proteins. Mol Biol Evol. 2005;22:104-16 pubmed
    ..proteins with highly conserved plant homeodomain (PHD) motifs and several splicing isoforms of the ING1 and ING2 gene have been identified...
  24. Sarker K, Kataoka H, Chan A, Netherton S, Pot I, Huynh M, et al. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. J Biol Chem. 2008;283:13269-79 pubmed publisher
    ..Here, we demonstrate a role for the protein ING2 in mediating responses by the transforming growth factor (TGF)-beta-Smad signaling pathway...
  25. Larrieu D, Ythier D, Binet R, Brambilla C, Brambilla E, Sengupta S, et al. ING2 controls the progression of DNA replication forks to maintain genome stability. EMBO Rep. 2009;10:1168-74 pubmed publisher
    Inhibitor of growth 2 (ING2) is a candidate tumour suppressor gene the expression of which is frequently lost in tumours...
  26. Zhong J, Yang L, Liu N, Zheng J, Lin C. Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells. Dig Dis Sci. 2013;58:3189-97 pubmed publisher
    The inhibitor of growth (ING) family is involved in multiple cellular functions, but the role of ING2 in gastric cancer progression is unclear...
  27. Pan Y, Zhang X, Xu D, Bao W, Lin A, Xu H, et al. Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients. Neoplasma. 2014;61:468-75 pubmed publisher
    The inhibitor of growth 2 (ING2) is a member of lNG family, involved in cell cycle regulation, DNA repair, apoptosis and senescence, and participating in chromatin remodeling and transcriptional regulation by histone modification...
  28. Chattopadhyay C, Hawke D, Kobayashi R, Maity S. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004;32:3632-41 pubmed
    ..Here we show that the p32 protein, previously identified as the ASF/SF2 splicing factor-associated protein, copurified with the CBF complex...
  29. Okano T, Gemma A, Hosoya Y, Hosomi Y, Nara M, Kokubo Y, et al. Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer. Oncol Rep. 2006;15:545-9 pubmed
    ..b>ING2, another gene in the ING family, was identified and cloned...
  30. Kuzmichev A, Zhang Y, Erdjument Bromage H, Tempst P, Reinberg D. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol. 2002;22:835-48 pubmed
    ..The N-terminal domain of p33 is present in several uncharacterized human proteins. We show that overexpression of p33ING1b suppresses cell growth in a manner dependent on the intact Sin3-HDAC-interacting domain. ..
  31. Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, et al. The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis. Nat Commun. 2014;5:3733 pubmed publisher
    ..These findings provide evidence that neddylation is important in HECT ubiquitin ligase activation and shed new light on the tumour-promoting role of Smurf1...
  32. Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, et al. The role of WDR5 in silencing human fetal globin gene expression. Haematologica. 2012;97:1632-40 pubmed publisher
    ..We found that WDR5 interacted with HDAC1 and a PHD domaincontaining protein, ING2 (inhibitor of growth), an H3K4me3 mark reader, to enhance ?-globin gene transcriptional repression...
  33. Yang S, Baxter E, Van Doren M. Phf7 controls male sex determination in the Drosophila germline. Dev Cell. 2012;22:1041-51 pubmed publisher
    ..We propose that PHF7 acts as a conserved epigenetic "reader" that activates the male germline sexual program. ..
  34. Varier R, Outchkourov N, de Graaf P, van Schaik F, Ensing H, Wang F, et al. A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. EMBO J. 2010;29:3967-78 pubmed publisher
    ..Based on our observations, we propose that a histone H3 phospho-methyl switch regulates TFIID-mediated transcription during mitotic progression of the cell cycle. ..
  35. Ythier D, Brambilla E, Binet R, Nissou D, Vesin A, de Fraipont F, et al. Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma. Lung Cancer. 2010;69:180-6 pubmed publisher
    b>ING2 is a candidate tumor suppressor gene involved in cell cycle control, apoptosis and senescence. Furthermore, we have recently shown that loss of ING2 expression is associated with increased genome instability...
  36. Wang Y, Wang J, Li G. Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. FEBS Lett. 2006;580:3787-93 pubmed
    The plant homodomain (PHD) of ING2 was shown to regulate p53-dependent apoptosis through phosphoinositides signaling. However, the role of a predicted leucine zipper-like (LZL) motif in N-terminus of ING2 is unclear...
  37. Lu F, Dai D, Martinka M, Ho V, Li G. Nuclear ING2 expression is reduced in human cutaneous melanomas. Br J Cancer. 2006;95:80-6 pubmed
    ..As ING2 exhibits 58...
  38. Goeman F, Otto K, Kyrylenko S, Schmidt O, Baniahmad A. ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9. Biochim Biophys Acta. 2008;1783:1673-80 pubmed publisher
    b>p33ING2 belongs to the ING-gene family that is involved in tumor suppression, DNA repair, cell cycle regulation, and cellular senescence. Most functions are dependent on the tumor suppressor p53...
  39. Fegers I, Kob R, Eckey M, Schmidt O, Goeman F, Papaioannou M, et al. The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing. J Proteome Res. 2007;6:4182-8 pubmed
    ..Interestingly, expression of p33ING1 and p33ING2 is able to induce premature senescence in primary human fibroblasts...
  40. Vicinanza M, Korolchuk V, Ashkenazi A, Puri C, Menzies F, Clarke J, et al. PI(5)P regulates autophagosome biogenesis. Mol Cell. 2015;57:219-34 pubmed publisher
  41. Zhang H, Pan K, Wang H, Weng D, Song H, Zhou J, et al. Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma. Cancer Lett. 2008;261:183-92 pubmed
    The inhibitor of growth (ING) family member 2 (ING2) is a newly discovered member of ING family that can regulate a wide range of cellular processes including cell growth arrest, apoptosis, and DNA repair...
  42. Han X, Bai X, Sun Y, Yang Y. Nuclear ING2 expression is reduced in osteosarcoma. Oncol Rep. 2014;32:1967-72 pubmed publisher
    Osteosarcoma is a high-grade malignant bone tumor. Loss of inhibitor of growth 2 (ING2) expression has been demonstrated in numerous types of cancers...
  43. Unoki M, Kumamoto K, Robles A, Shen J, Zheng Z, Harris C. A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. FEBS Lett. 2008;582:3868-74 pubmed publisher
    We identified a novel inhibitor of growth family member 2 (ING2) isoform, ING2b, which shares exon 2 with ING2a, but lacks the N-terminal p53 binding region. Contrary to ING2a, ING2b's promoter has no p53 binding sites...