Gene Symbol: IMPACT
Description: impact RWD domain protein
Alias: RWDD5, protein IMPACT, Impact homolog, RWD domain containing 5, imprinted and ancient gene protein homolog
Species: human
Products:     IMPACT

Top Publications

  1. Mokdad A, Forouzanfar M, Daoud F, El Bcheraoui C, Moradi Lakeh M, Khalil I, et al. Health in times of uncertainty in the eastern Mediterranean region, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Glob Health. 2016;4:e704-13 pubmed publisher
    ..The Arab uprisings and the wars that followed, coupled with ageing and population growth, will have a major impact on the region's health and resources...
  2. Prasanth M, Sivamaruthi B, Chaiyasut C, Tencomnao T. A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients. 2019;11: pubmed publisher
    ..antioxidant candidates that could nullify excess endogenous ROS and RNS inside the body, and thereby diminish the impact of photoaging...
  3. Park W, Zwink N, Rösch W, Schmiedeke E, Stein R, Schmidt D, et al. Sexual function in adult patients with classic bladder exstrophy: A multicenter study. J Pediatr Urol. 2015;11:125.e1-6 pubmed publisher
    ..a spectrum of congenital anomalies that represents the severe end of urorectal malformations, and has a profound impact on continence as well as sexual and renal functions...
  4. Dowarah R, Verma A, Agarwal N, Singh P, Singh B. Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets. PLoS ONE. 2018;13:e0192978 pubmed publisher
  5. Sardanelli F, Aase H, Álvarez M, Azavedo E, Baarslag H, Balleyguier C, et al. Position paper on screening for breast cancer by the European Society of Breast Imaging (EUSOBI) and 30 national breast radiology bodies from Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Denmark, Estonia, Finland, Fran. Eur Radiol. 2017;27:2737-2743 pubmed publisher
    ..mammography for population-based screening, demonstrated to reduce breast cancer (BC) mortality and treatment impact. According to the International Agency for Research on Cancer, the reduction in mortality is 40 % for women ..
  6. Mazzio E, Lewis C, Soliman K. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017;14:409-425 pubmed
    ..12]. The anti-cancer effects of the historically used frankincense sap (BSE) appear to involve major impact on the ER/UPR response, concomitant to effecting multiple targets counter to the growth, proliferation and ..
  7. Baloyannis S. Brain capillaries in Alzheimer's disease. Hell J Nucl Med. 2015;18 Suppl 1:152 pubmed
    ..Due to the severity and the social impact of the disease an ongoing research activity is in climax nowadays, associated with many legal, social, ethical, ..
  8. Kujundzic M. [The role of biologic therapy in the treatment of extraintestinal manifestations and complications of inflammatory bowel disease]. Acta Med Croatica. 2013;67:195-201 pubmed
    ..Anti-TNF therapy is also ineffective in treatment of PSC and has no impact on disease course and outcome...
  9. Gharagozloo P, Gutiérrez Adán A, Champroux A, Noblanc A, Kocer A, Calle A, et al. A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models. Hum Reprod. 2016;31:252-62 pubmed publisher
    ..Our results, if confirmed in humans, will impact clinical fertility practice because they support the concept of using an efficacious antioxidant supplementation ..

More Information

Publications163 found, 100 shown here

  1. Chansamouth V, Thammasack S, Phetsouvanh R, Keoluangkot V, Moore C, Blacksell S, et al. The Aetiologies and Impact of Fever in Pregnant Inpatients in Vientiane, Laos. PLoS Negl Trop Dis. 2016;10:e0004577 pubmed publisher
    ..Globally, malaria has been the pathogen most intensively investigated in relation to impact on pregnancy, but there has been relatively little research on the aetiology and impact of other diseases...
  2. Yu H, Wang D, Zou L, Zhang Z, Xu H, Zhu F, et al. Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer's disease. Arch Toxicol. 2018;92:1363-1382 pubmed publisher
    ..copper intake can lead to neurotoxicity, but there is a lack of comprehensive understanding on the potential impact of copper exposure especially at a low-dose on brain...
  3. Candeias E, Duarte A, Sebastião I, Fernandes M, Placido A, Carvalho C, et al. Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology. Mol Neurobiol. 2017;54:6471-6489 pubmed publisher
    ..During the past two decades, T2D has been widely shown to have a major impact in the brain...
  4. Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Niksic M, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023-1075 pubmed publisher
    ..must recognise population-based cancer registries as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems for all patients diagnosed with cancer...
  5. Rossati A. Global Warming and Its Health Impact. Int J Occup Environ Med. 2017;8:7-20 pubmed publisher
    ..All these have an impact on human health, causing non-communicable diseases such as injuries during natural disasters, malnutrition during ..
  6. Liu S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:88-105 pubmed publisher
    ..The optimal level of exogenous lipase supplementation in young grass carp (255-771 g) was estimated to be 1193 U kg(-1) diet. ..
  7. Ercoli G, Tani C, Pezzicoli A, Vacca I, Martinelli M, Pecetta S, et al. LytM proteins play a crucial role in cell separation, outer membrane composition, and pathogenesis in nontypeable Haemophilus influenzae. MBio. 2015;6:e02575 pubmed publisher
    ..Interestingly, by modulating the surface composition of virulence determinants, EnvC also has an impact on NTHI pathogenesis.
  8. Aagaard H, Uhrenfeldt L, Spliid M, Fegran L. Parents' experiences of transition when their infants are discharged from the Neonatal Intensive Care Unit: a systematic review protocol. JBI Database System Rev Implement Rep. 2015;13:123-32 pubmed publisher
    ..volume of preterm infants with extremely low gestational age who need neonatalogy assistance, and ii) the impact of the parents' presence in the NICU to support the infant's development...
  9. Udina M, Navines R, Egmond E, Oriolo G, Langohr K, Gimenez D, et al. Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..This study aimed to evaluate the impact on mood of initiating IFN-alpha and ribavirin treatment in a cohort of patients with chronic hepatitis C...
  10. Schwabl P, Hambruch E, Seeland B, Hayden H, Wagner M, Garnys L, et al. The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction. J Hepatol. 2017;66:724-733 pubmed publisher
    ..The impact of the novel non-steroidal and selective FXR agonist PX20606 on portal hypertension and fibrosis was explored in ..
  11. Chang C, Ortiz K, Ansari A, Gershwin M. The Zika outbreak of the 21st century. J Autoimmun. 2016;68:1-13 pubmed publisher
    ..The overall public health impact of these above findings highlights the need for a rapid but specific diagnostic test for blood banks worldwide to ..
  12. Jing Y, Cai D, Chen Q, Xiong Q, Hu T, Yao Y, et al. Liuwei Dihuang soft capsules attenuates endothelial cell apoptosis to prevent atherosclerosis through GPR30-mediated regulation in ovariectomized ApoE-deficient mice. J Ethnopharmacol. 2017;208:185-198 pubmed publisher
    ..However, little attention has been paid to the potential impact of LWDH on atherosclerosis (AS) associated with female menopause...
  13. Seven E. Overweight, hypertension and cardiovascular disease: focus on adipocytokines, insulin, weight changes and natriuretic peptides. Dan Med J. 2015;62:B5163 pubmed
    ..Paper II: Five-year weight changes were associated with blood pressure alterations and had a substantial impact on both fasting and two-hour post-glucose serum insulin levels...
    ..An increasing interest regards the long-term cardiovascular effects of SSRIs and in particular their impact on vascular development and function in fetuses and in adult life [26-29]...
  15. Agarwal A, Aponte Mellado A, Premkumar B, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49 pubmed publisher
    ..In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear...
  16. Griffiths K, Aggarwal B, Singh R, Buttar H, Wilson D, de Meester F. Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention. Diseases. 2016;4: pubmed publisher
    ..The impact of antioxidants and anti-inflammatory agents on cancer and cardiovascular disease, and the interventive mechanisms ..
  17. Selvaraju S, Parthipan S, Somashekar L, Binsila B, Kolte A, Arangasamy A, et al. Current status of sperm functional genomics and its diagnostic potential of fertility in bovine (Bos taurus). Syst Biol Reprod Med. 2018;64:484-501 pubmed publisher
    ..Such studies have a direct impact on the bovine dairy industry, wherein AI is practiced...
  18. Van Zuuren E, Albusta A, Fedorowicz Z, Carter B, Pijl H. Selenium supplementation for Hashimoto's thyroiditis. Cochrane Database Syst Rev. 2013;:CD010223 pubmed publisher
    ..Selenium supplementation did not appear to have a statistically significant impact on the incidence of adverse events (RR 2.93, 95% CI 0.12 to 70.00; and RR 2.63, 95% CI 0.11 to 62.95)...
  19. Tian J, Wu F, Yang C, Jiang M, Liu W, Wen H. Dietary lipid levels impact lipoprotein lipase, hormone-sensitive lipase, and fatty acid synthetase gene expression in three tissues of adult GIFT strain of Nile tilapia, Oreochromis niloticus. Fish Physiol Biochem. 2015;41:1-18 pubmed publisher
    ..FAS did not have tissue-specific regulation; however, the regulation of dietary lipids on LPL expression is tissue specific. FAS was a negative feedback regulator on fat deposition, and HSL was an indicator of fat content in tilapia. ..
  20. Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, et al. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice. J Ethnopharmacol. 2017;198:479-488 pubmed publisher
    ..Peritoneal macrophages were collected to study the impact of HLF on cholesterol efflux, formation of foam cell and the expression of ATP binding cassette transporter A1 (..
  21. Maggi R, Kramer F. A review on the occurrence of companion vector-borne diseases in pet animals in Latin America. Parasit Vectors. 2019;12:145 pubmed publisher
    Companion vector-borne diseases (CVBDs) are an important threat for pet life, but may also have an impact on human health, due to their often zoonotic character...
  22. Rust P, Ekmekcioglu C. Impact of Salt Intake on the Pathogenesis and Treatment of Hypertension. Adv Exp Med Biol. 2017;956:61-84 pubmed publisher
    ..7 g/day) should be increased and alcohol consumption limited. In addition, regular physical activity (endurance, dynamic resistance, and isometric resistance training) is very important. ..
  23. Bertoletti A, Tan A, Koh S. T-cell therapy for chronic viral hepatitis. Cytotherapy. 2017;19:1317-1324 pubmed publisher
    ..In addition, while frequency and impact of viral mutations in T cell epitopes are frequently detectable in HCV infections [10], viral mutations affecting ..
  24. Gu J, Lei Y, Huang Y, Zhao Y, Li J, Huang T, et al. Fab fragment glycosylated IgG may play a central role in placental immune evasion. Hum Reprod. 2015;30:380-91 pubmed publisher
    ..Should the mechanism proposed here be confirmed, it will have a direct impact on our understanding of the physiology and pathology of human reproduction and offer new possibilities for the ..
  25. Perfilyev A, Dahlman I, Gillberg L, Rosqvist F, Iggman D, Volkov P, et al. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial. Am J Clin Nutr. 2017;105:991-1000 pubmed publisher
    ..In addition, we present data that suggest that baseline DNA methylation can predict weight increase in response to overfeeding in humans. This trial was registered at as NCT01427140. ..
  26. Claro Da Silva T, Hiller C, Gai Z, Kullak Ublick G. Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016;163:77-87 pubmed publisher
    ..To study the impact of vitamin D3 on genes relevant for the transport and metabolism of nutrients and drugs, we employed next-..
  27. Barrientos G, Pussetto M, Rose M, Staff A, Blois S, Toblli J. Defective trophoblast invasion underlies fetal growth restriction and preeclampsia-like symptoms in the stroke-prone spontaneously hypertensive rat. Mol Hum Reprod. 2017;23:509-519 pubmed publisher
    What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SHRSP showed an impaired remodeling of the spiral arteries and abnormal ..
  28. Amato L, Fusco D, Acampora A, Bontempi K, Rosa A, Colais P, et al. Volume and health outcomes: evidence from systematic reviews and from evaluation of Italian hospital data. Epidemiol Prev. 2017;41:1-128 pubmed publisher
    ..Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare...
  29. Santos J, Bisinotto R, Ribeiro E. Mechanisms underlying reduced fertility in anovular dairy cows. Theriogenology. 2016;86:254-62 pubmed publisher
    ..One approach to minimize the impact of anovulation on fertility is supplementation with progesterone during recruitment, selection and final stages of ..
  30. Medenica S, Nedeljkovic O, Radojevic N, Stojkovic M, Trbojevic B, Pajovic B. Thyroid dysfunction and thyroid autoimmunity in euthyroid women in achieving fertility. Eur Rev Med Pharmacol Sci. 2015;19:977-87 pubmed
    ..autoimmunity, in thyroid dysfunction adversely affects conception and pregnancy outcomes, but it is unclear what impact has isolated eumetabolic thyroid autoimmunity in achieving fertility, especially in women undergoing in vitro ..
  31. Rohde U. EndoBarrier gastrointestinal liner. Delineation of underlying mechanisms and clinical effects. Dan Med J. 2016;63: pubmed
    ..Furthermore, since the endocrine impact of the DJBS is not fully elucidated, and DJBS is expected to mimic RYGB, we investigated postprandial metabolic ..
  32. Morris J, Twizeyemariya A, Grimmer K. What is the current evidence of the impact on quality of life whilst waiting for management/treatment of orthopaedic/musculoskeletal complaints? A systematic scoping review. Qual Life Res. 2018;27:2227-2242 pubmed publisher
    ..The scoping search yielded 142 articles, of which 18 reported on impact on QoL. These studies reported only on patients waiting for hip and/or knee replacement surgery...
  33. Acarturk C, Konuk E, Cetinkaya M, Senay I, Sijbrandij M, Cuijpers P, et al. EMDR for Syrian refugees with posttraumatic stress disorder symptoms: results of a pilot randomized controlled trial. Eur J Psychotraumatol. 2015;6:27414 pubmed publisher
    ..The main outcome measures were Impact of Event Scale-Revised (IES-R) and Beck Depression Inventory (BDI-II) at posttreatment and 4-week follow-up...
  34. Javadi Khederi S, Khanjani M, Gholami M, Panzarino O, De Lillo E. Influence of the erineum strain of Colomerus vitis (Acari: Eriophyidae) on grape (Vitis vinifera) defense mechanisms. Exp Appl Acarol. 2018;75:1-24 pubmed publisher
    ..In order to evaluate the impact of GEM on grape and its defense mechanisms against the mite, an exploratory study was carried out on 19 cultivars (..
  35. Benelli G. Mode of action of nanoparticles against insects. Environ Sci Pollut Res Int. 2018;25:12329-12341 pubmed publisher
    ..Both silver and graphene oxide nanoparticles have a significant impact on insect antioxidant and detoxifying enzymes, leading to oxidative stress and cell death...
  36. Liu Y, Jolly C, Braun S, Janssen T, Scherer E, Steinhoff J, et al. Effects of a dexamethasone-releasing implant on cochleae: A functional, morphological and pharmacokinetic study. Hear Res. 2015;327:89-101 pubmed publisher
    This study evaluated the impact of a dexamethasone-releasing silicone implant on hearing function preservation, cochlear morphology and perilymph pharmacokinetics after cochlear implantation...
  37. Chauvet S, Bridoux F, Ecotière L, Javaugue V, Sirac C, Arnulf B, et al. Kidney diseases associated with monoclonal immunoglobulin M-secreting B-cell lymphoproliferative disorders: a case series of 35 patients. Am J Kidney Dis. 2015;66:756-67 pubmed publisher
    ..Retrospective study; insufficient population to establish the impact of chemotherapy...
  38. Blake D. Eimeria genomics: Where are we now and where are we going?. Vet Parasitol. 2015;212:68-74 pubmed publisher
    ..been slower for parasites of animals which lack zoonotic potential, but the deficit is now being redressed with impact likely in the areas of drug and vaccine development, molecular diagnostics and population biology...
  39. Mizuma A, Nagata E, Yasuda T, Kouchi M, Nakayama T, Honma K, et al. Botulinum toxin A is effective to treat tension-type headache caused by hemifacial spasm. J Clin Neurosci. 2017;44:284-288 pubmed publisher
    ..Numerical Rating Scale (NRS) and Headache Impact Test-6 (HIT-6) scores for headache severity were compared between the 6-week baseline before BoNT/A therapy and 6-..
  40. Mortuaire G, Leroy X, Gengler I, Chevalier D, Prin L, Picry A. Histopathological classification of refractory chronic rhinosinusitis with nasal polyps. Histol Histopathol. 2015;30:1447-54 pubmed publisher
    ..Further studies concerning mucosal remodelling and outcome assessment after sinus surgery are required to evaluate the impact of our classification on a daily basis.
  41. Fleury Y, Arroyo D, Couchepin C, Robert Ebadi H, Righini M, Lobrinus J, et al. Impact of intravascular thrombosis on failure of radial arterial catheters in critically ill patients: a nested case-control study. Intensive Care Med. 2018;44:553-563 pubmed publisher
    ..Most failing radial arterial catheters had no luminal obstruction, but were associated with an intravascular thrombosis. Among predictive factors, arterial blood sampling frequency is the most susceptible to intervention. ..
  42. Di Cristofaro J, Reynaud Gaubert M, Carlini F, Roubertoux P, Loundou A, Basire A, et al. HLA-G*01:04∼UTR3 Recipient Correlates With Lower Survival and Higher Frequency of Chronic Rejection After Lung Transplantation. Am J Transplant. 2015;15:2413-20 pubmed publisher
    ..The aim of this retrospective study was to determine the impact of HLA-G alleles and UTR polymorphism from LTx recipients on anti-HLA allo-immunization risk, overall survival and ..
  43. Cieniewicz B, Dong Q, Li G, Forrest J, Mounce B, Tarakanova V, et al. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture. J Virol. 2015;89:6562-74 pubmed publisher
    ..The impact of the inflammasome response on gammaherpesvirus replication and latency in vivo is not known...
  44. Card R, Mafura M, Hunt T, Kirchner M, Weile J, Rashid M, et al. Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor. Antimicrob Agents Chemother. 2015;59:4410-6 pubmed publisher
    The aim of this study was to assess the impact of ciprofloxacin, clindamycin, and placebo administration on culturable Gram-negative isolates and the antibiotic resistance genes they harbor...
  45. House L, Morris R, Barnes T, Lantier L, Cyphert T, McGuinness O, et al. Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance. Cardiovasc Diabetol. 2015;14:56 pubmed publisher
    ..The impact of NO donor infusion on insulin-stimulated whole-body and muscle glucose uptake (hyperinsulinemic-euglycemic ..
  46. Reddy V, Reddy G. Role of crystallins in diabetic complications. Biochim Biophys Acta. 2016;1860:269-77 pubmed publisher
    ..Therefore, this review highlights the current data on the impact of chronic hyperglycemia on expression, distribution, glycation, phosphorylation, chaperone-like function and, ..
  47. Bertrand L, Toborek M. Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz. Mol Pharmacol. 2015;88:304-15 pubmed publisher
    ..virus (HIV) treatment have toxic effects that result in various cellular and tissue pathologies; however, their impact on the cells composing the blood-brain barrier is poorly understood...
  48. Cicero A, Benelli M, Brancaleoni M, Dainelli G, Merlini D, Negri R. Middle and Long-Term Impact of a Very Low-Carbohydrate Ketogenic Diet on Cardiometabolic Factors: A Multi-Center, Cross-Sectional, Clinical Study. High Blood Press Cardiovasc Prev. 2015;22:389-94 pubmed publisher
  49. Lone A, Atci E, Renslow R, Beyenal H, NOH S, Fransson B, et al. Colonization of epidermal tissue by Staphylococcus aureus produces localized hypoxia and stimulates secretion of antioxidant and caspase-14 proteins. Infect Immun. 2015;83:3026-34 pubmed publisher
    ..These results are consistent with a localized biological impact from S. aureus in response to colonization of the skin surface.
  50. Muser D, Santangeli P, Castro S, Liang J, Enríquez A, Werner T, et al. Prognostic role of serial quantitative evaluation of 18F-fluorodeoxyglucose uptake by PET/CT in patients with cardiac sarcoidosis presenting with ventricular tachycardia. Eur J Nucl Med Mol Imaging. 2018;45:1394-1404 pubmed publisher
    ..We sought to investigate the clinical impact of serial quantitative FDG uptake analysis in patients with CS presenting with ventricular tachycardia (VT) ..
  51. Bryk A, Wypasek E, Awsiuk M, Maj D, Undas A. Warfarin Metabolites in Patients Following Cardiac Valve Implantation: A Contribution of Clinical and Genetic Factors. Cardiovasc Drugs Ther. 2015;29:257-64 pubmed publisher
    ..R-warfarin is metabolized by multiple cytochromes P450. We sought to assess the impact of clinical and genetic factors on circulating warfarin metabolites following valve implantation...
  52. Dagnachew S, Bezie M, Terefe G, Abebe G, Barry J, Goddeeris B. Comparative clinico-haematological analysis in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia. Acta Vet Scand. 2015;57:24 pubmed publisher
    ..the Northwest region, is affected by both tsetse and non-tsetse fly transmitted trypanosomosis, with significant impact on livestock productivity...
  53. Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen R, et al. Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget. 2015;6:15077-94 pubmed
    ..Loss of Cx3cr1 in microglia in a monocyte-free environment had no impact on tumor growth and did not alter microglial migration...
  54. Wang L, Gao X, Li J, Yu H, Su H, Liu L, et al. Effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma. Asian Pac J Cancer Prev. 2015;16:3977-80 pubmed
    ..analgesia before anesthesia and after surgery can effectively reduce the levels of plasma stress hormones and improve analgesic effects in surgical patients with thyroid carcinoma, and without conspicuous impact on haemodynamics.
  55. Farsalinos K, Voudris V, Poulas K. Are metals emitted from electronic cigarettes a reason for health concern? A risk-assessment analysis of currently available literature. Int J Environ Res Public Health. 2015;12:5215-32 pubmed publisher
    Studies have found that metals are emitted to the electronic cigarette (EC) aerosol. However, the potential health impact of exposure to such metals has not been adequately defined...
  56. Peng C, Uygun S, Shiu S, Last R. The Impact of the Branched-Chain Ketoacid Dehydrogenase Complex on Amino Acid Homeostasis in Arabidopsis. Plant Physiol. 2015;169:1807-20 pubmed publisher
    ..Together, these results demonstrate the consequences of blocking BCAA catabolism during both normal growth conditions and under energy-limited conditions. ..
  57. Rochette P, Bourget A, Sanabria Solano C, Lahmidi S, Lavallée G, Pearson A. Mutation of UL24 impedes the dissemination of acute herpes simplex virus 1 infection from the cornea to neurons of trigeminal ganglia. J Gen Virol. 2015;96:2794-805 pubmed publisher
    ..Herein, we investigated how UL24 contributed to acute infection of TG. Our results comparing the impact of UL24 on viral titres in eye tissue versus in tear films did not reveal a general defect in virus release from ..
  58. Bartoszek G, Fischer U, Grill E, Müller M, Nadolny S, Meyer G. Impact of joint contracture on older persons in a geriatric setting: A cross-sectional study. Z Gerontol Geriatr. 2015;48:625-32 pubmed publisher
    ..phenomenon in older persons and are assessed by measuring the range of motion; however, little is known about the impact of joint contractures on activities of daily living (ADL)...
  59. Otabil K, Tenkorang S. Filarial hydrocele: a neglected condition of a neglected tropical disease. J Infect Dev Ctries. 2015;9:456-62 pubmed publisher
    ..This review highlights the socio-economic impact of the disease, the role of the immune system in hydrocele development, current diagnostic approaches, and the ..
  60. Kuo P, Chen S, Shyr Y, Kuo Y, Lee R, Wang S. Hepatoid carcinoma of the pancreas. World J Surg Oncol. 2015;13:185 pubmed publisher
    ..0 months. Unresectability, hepatic, and lymph node metastases are associated with negative impact on survival outcome...
  61. Cao L, Wang S, Zhang Y, Wong K, Nakatsu G, Wang X, et al. Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A. Oncogene. 2018;37:3601-3616 pubmed publisher
    ..Here we elucidated the functional significance, molecular mechanisms and clinical impact of ZNF471 in gastric cancer...
  62. Abdelhalim A, Elshal A, Elsawy A, Helmy T, Orban H, Dawaba M, et al. Bricker Conduit for Pediatric Urinary Diversion--Should we Still Offer It?. J Urol. 2015;194:1414-9 pubmed publisher
    ..The Bricker conduit does not seem to halt renal deterioration in children. Negative impact on growth and quality of life, and the anticipated rate of complications are significant limitations of the ..
  63. Jia H, Jiao Y, Wang G, Li Y, Jia H, Wu H, et al. Genetic diversity of male and female Chinese bayberry (Myrica rubra) populations and identification of sex-associated markers. BMC Genomics. 2015;16:394 pubmed publisher
    ..Knowledge of males may have a major impact on conservation and genetic improvement as well as on breeding. Using 84 polymorphic SSRs, we genotyped 213 M...
  64. Jost P, Svobodová H, Stetina R. Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay. Chem Biol Interact. 2015;237:31-7 pubmed publisher
    Sulfur mustard is a highly toxic chemical warfare agent with devastating impact on intoxicated tissues. DNA cross-links are probably the most toxic DNA lesions induced in the cell by sulfur mustard...
  65. Li Y, Melnikov A, Levenson V, Guerra E, Simeone P, Alberti S, et al. A seven-gene CpG-island methylation panel predicts breast cancer progression. BMC Cancer. 2015;15:417 pubmed publisher
    ..Our findings identify CpG-island methylation profiles with deep impact on clinical outcome, paving the way for use as novel prognostic assays in clinical settings.
  66. Yamasaki S, Chihara D, Kim S, Izutsu K, Iwato K, Fukuda T, et al. Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma. Ann Hematol. 2018;97:1445-1452 pubmed publisher
    ..0054) were risk factors after allogeneic HCT. Strategies that carefully select R/R MCL patients for autologous HCT may allow the identification of individuals suitable for allogeneic HCT. ..
  67. Tanguy M, Kouatchet A, Tanguy B, Pichard E, Fanello S, Joly Guillou M. Management of an Acinetobacter baumannii outbreak in an intensive care unit. Med Mal Infect. 2017;47:409-414 pubmed publisher
    ..baumannii outbreak and to evaluate the control measures taken. The secondary objective was to evaluate the impact of the electronic alert system on the incidence of multidrug resistance to antibiotics...
  68. Goldmuntz E, Cassedy A, Mercer Rosa L, Fogel M, Paridon S, Marino B. Exercise Performance and 22q11.2 Deletion Status Affect Quality of Life in Tetralogy of Fallot. J Pediatr. 2017;189:162-168 pubmed publisher
    ..The patients with a 22q11.2 deletion and their parents reported lower total and Disease Impact scores compared with the group without a deletion on the Pediatric Cardiac Quality of Life Inventory...
  69. de Aguiar Cipriano P, Ekici L, Barnes R, Gomes C, Talcott S. Pre-heating and polyphenol oxidase inhibition impact on extraction of purple sweet potato anthocyanins. Food Chem. 2015;180:227-34 pubmed publisher
    ..Minimizing the impact of PPO with heat was critical to the extraction and recovery of PSP anthocyanins, suitable for food use.
  70. López Vicario C, Rius B, Alcaraz Quiles J, García Alonso V, Lopategi A, Titos E, et al. Pro-resolving mediators produced from EPA and DHA: Overview of the pathways involved and their mechanisms in metabolic syndrome and related liver diseases. Eur J Pharmacol. 2016;785:133-143 pubmed publisher
    ..inflammatory status present in adipose tissue of obese individuals and describe the potential therapeutic impact of these bioactive lipid autacoids on the prevention of hepatic co-morbidities associated with obesity and the ..
  71. Sah S, Varshney U. Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities. Biochemistry. 2015;54:3504-13 pubmed publisher
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  72. Ranji P, Akbarzadeh A, Rahmati Yamchi M. Associations of Probiotics with Vitamin D and Leptin Receptors and their Effects on Colon Cancer. Asian Pac J Cancer Prev. 2015;16:3621-7 pubmed
    ..Recent studies have suggested that microbial and environmental factors including diet and lifestyle can impact on colon cancer development...
  73. Fleischmann I, Warschkow R, Beutner U, Marti L, Schmied B, Steffen T. Improved survival after retrieval of 12 or more regional lymph nodes in appendiceal cancer. Eur J Surg Oncol. 2017;43:1876-1885 pubmed publisher
    ..The impact of the number of RLN removed on OS and CSS was assessed using joinpoint regression, Cox regression, and propensity ..
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    ..Angers showed a novel helical structure in place of hole 'a' on the outer edge of γD likely to have a negative impact on fibrinogen assembly and secretion...
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    ..To evaluate the impact of a TBP guidance summary card on HCWs' decision-making about the appropriate implementation of TBPs...
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    Photoaging is recognized as the factor damaging skin-barrier function. The aim of this study was to examine the impact of ultraviolet (UV) irradiation on the cutaneous penetration of soft nanoparticles, including nanostructured lipid ..
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    ..The overall impact of K and Na nutrition plays down any indirect effect on stomatal limitation and rather demonstrates the centrality ..
  78. Fukuyama T, Takahashi Y, Kubota Y, Mogami Y, Imai K, Kondo Y, et al. Semi-quantitative analyses of antibodies to N-methyl-d-aspartate type glutamate receptor subunits (GluN2B & GluN1) in the clinical course of Rasmussen syndrome. Epilepsy Res. 2015;113:34-43 pubmed publisher
    ..These antibodies may impact the pathophysiology of RS in the most active stage, and could be a marker for active inflammation in the clinical ..
  79. Antosh D, High R, Brown H, Oliphant S, Abed H, Philip N, et al. Feasibility of prophylactic salpingectomy during vaginal hysterectomy. Am J Obstet Gynecol. 2017;217:605.e1-605.e5 pubmed publisher
    ..objectives included identification of factors associated with unsuccessful salpingectomy and assessment of its impact on operating time, blood loss, surgical complications, and menopausal symptoms...
  80. Gupta I, Roy A. Economic Studies on Non-Communicable Diseases and Injuries in India: A Systematic Review. Appl Health Econ Health Policy. 2018;16:303-315 pubmed publisher
    ..Our objective was to understand the extent to which economic analysis has been used in India to (1) analyze the impact of NCDI and (2) evaluate prevention and treatment interventions...
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    ..A subgroup of patients with 3 MLN had a better SS with ALND, possibly due to an under-staging of the SLNB-alone group. ..
  82. Fan J, Semenzin E, Meng W, Giubilato E, Zhang Y, Critto A, et al. Ecological status classification of the Taizi River Basin, China: a comparison of integrated risk assessment approaches. Environ Sci Pollut Res Int. 2015;22:14738-54 pubmed publisher
    ..2012) indicates that the selection of indicators and integrating methodologies can have a relevant impact on the classification of the ecological status...
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    ..In order to investigate the impact of this SNP on circuit function, we used voltage-sensitive dye imaging in hippocampal slices and in vivo ..
  84. Tillault A, Fourmann J, Loegler C, Wieden H, Kothe U, Charpentier B. Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5. RNA. 2015;21:1233-9 pubmed publisher
    ..The impact of the mutations was analyzed for unguided modifications U(55) in tRNA and U2603 in 23S rRNA, and for activity of ..
  85. Juenemann M, Braun T, Doenges S, Nedelmann M, Mueller C, Bachmann G, et al. Aquaporin-4 autoantibodies increase vasogenic edema formation and infarct size in a rat stroke model. BMC Immunol. 2015;16:30 pubmed publisher
    ..9.2 ms ± 5.2 ms; p < 0.05). These results support the functional impact of NMO-antibodies and also offer an in-vivo-applicable animal model to investigate the properties of AQP4 in ..
  86. Schwartz M, Peshkin B, Isaacs C, Willey S, Valdimarsdottir H, Nusbaum R, et al. Randomized trial of proactive rapid genetic counseling versus usual care for newly diagnosed breast cancer patients. Breast Cancer Res Treat. 2018;170:517-524 pubmed publisher
    ..genetic counseling participation, this did not result in increased rates of pre-surgical genetic testing or impact surgical decisions...
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    ..dissemination across primary care, the Veterans Health Administration (VA) is an ideal setting to examine the impact of the patient-centered medical home (PCMH) on diabetes outcomes...
  88. McClements L, Annett S, Yakkundi A, Robson T. The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases. Curr Mol Pharmacol. 2015;9:165-79 pubmed
    ..Due to this unique structure these proteins are able to facilitate protein-protein interactions which can impact significantly on a range of cellular processes such as cell signalling, differentiation, cell cycle progression, ..
  89. Urone N, Di Marco V, Cacopardo B, Craxì A, Ferraro D. Impact of HBV genotypes A and D genetic variability on infection evolution. Infect Genet Evol. 2015;33:281-7 pubmed publisher
    ..Moreover, the analysis of circulation of new HBV antigenic variants is fundamental for the epidemiological surveys and for the evaluation of the impact of viral evolution on vaccine prophylaxis strategies.
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    ..The prevalence and clinical impact of azole resistance in different patient populations are currently unclear...
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    ..Root protein content and root activity were observed to decrease. From the ultrastructural micrographs, visible impact on the mitochondria, endoplasmic reticulum and vacuole were detected...
  92. Pelzer U, Opitz B, Deutschinoff G, Stauch M, Reitzig P, Hahnfeld S, et al. Efficacy of Prophylactic Low-Molecular Weight Heparin for Ambulatory Patients With Advanced Pancreatic Cancer: Outcomes From the CONKO-004 Trial. J Clin Oncol. 2015;33:2028-34 pubmed publisher
    ..use of enoxaparin or chemotherapy alone to investigate the probable reduction in symptomatic VTEs and the impact on survival. A total of 312 patients were recruited as one of the protocol end points was reached...