Gene Symbol: IMPA2
Description: inositol monophosphatase 2
Alias: inositol monophosphatase 2, IMP 2, IMPase 2, inosine monophosphatase 2, inositol monophosphatase 2 variant 1, inositol monophosphatase 2 variant 2, inositol(myo)-1(or 4)-monophosphatase 2, myo-inositol monophosphatase 2, myo-inositol monophosphatase A2
Species: human
Products:     IMPA2

Top Publications

  1. Husain B, Nanavaty I, Marathe S, Rajendran R, Vaidya V. Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2015;61:1-9 pubmed publisher
    ..Further, we noted a regulation of signaling pathway genes like inositol monophosphatase 2 (Impa2), iodothyronine deiodinase 3 (Dio3), regulator of G-protein signaling 4 (Rgs4), alkaline ..
  2. Tomioka Y, Jiménez E, Salagre E, Arias B, Mitjans M, Ruiz V, et al. Association between genetic variation in the myo-inositol monophosphatase 2 (IMPA2) gene and age at onset of bipolar disorder. J Affect Disord. 2018;232:229-236 pubmed publisher
    ..The aim of this study was to evaluate if variants of the gene coding for myo-inositol monophosphatase (IMPA2) are linked to age at onset of BD. 235 bipolar patients were recruited and assessed...
  3. Blair M, Ma S, Abou Khalil B, Hedera P. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. Eur J Neurol. 2007;14:424-7 pubmed
    ..Non-coding polymorphisms in the myo-inositol monophosphatase 2 gene (IMPA2) have been suggested as a susceptibility factor for FS in Japanese patients...
  4. Li J, Huang S, Dai H, Wang J, Lin L, Xiao H, et al. A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia. J Cell Mol Med. 2017;21:658-664 pubmed publisher
    Previous studies with biological and genetic evidence indicate that the myo-inositol monophosphatase 2 (IMPA2) gene may influence schizophrenia. We performed a genetic association study in Han Chinese cohorts...
  5. Bloch P, Weller A, Doyle G, Ferraro T, Berrettini W, Hodge R, et al. Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1515-9 pubmed publisher
    ..The myo-inositol monophosphatase 2 gene (IMPA2) maps to this genomic region...
  6. Dimitrova A, Milanova V, Krastev S, Nikolov I, Toncheva D, Owen M, et al. Association study of myo-inositol monophosphatase 2 (IMPA2) polymorphisms with bipolar affective disorder and response to lithium treatment. Pharmacogenomics J. 2005;5:35-41 pubmed
    ..It is thought to exert its effect via the phosphatidylinositol signalling system. Myo-inositol monophosphatase 2 (IMPA2) codes for an enzyme in this system that is inhibited by lithium. It is located on 18p11...
  7. Matarin M, Brown W, Scholz S, Simon Sanchez J, Fung H, Hernandez D, et al. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol. 2007;6:414-20 pubmed
    ..Release of phase I results generated in these publicly available samples from each consenting individual makes this dataset a valuable resource for data-mining and augmentation. ..
  8. Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W, et al. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. Stroke. 2010;41:177-80 pubmed publisher
    ..The mechanism whereby the genetic variants exert their effects on ischemic stroke remains to be further elucidated. ..
  9. Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, et al. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. Neuropsychopharmacology. 2007;32:1727-37 pubmed
    ..In humans, the enzyme is encoded by two genes, IMPA1 and IMPA2. IMPA2 maps to 18p11...

More Information


  1. Jimenez E, Arias B, Mitjans M, Goikolea J, Roda E, Saiz P, et al. Genetic variability at IMPA2, INPP1 and GSK3? increases the risk of suicidal behavior in bipolar patients. Eur Neuropsychopharmacol. 2013;23:1452-62 pubmed publisher
    ..199 BP were recruited. Polymorphisms at the IMPA1 (rs915, rs1058401 and rs2268432) and IMPA2 (rs66938, rs1020294, rs1250171 and rs630110), INPP1 (rs3791809, rs4853694 and 909270), GSK3? (rs3745233) and GSK3? ..
  2. Yoshikawa T, Turner G, Esterling L, Sanders A, Detera Wadleigh S. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. Mol Psychiatry. 1997;2:393-7 pubmed
    ..2 region. We, therefore, designated this novel gene as IMP.18p. The physical position and possible function suggest that IMP.18p is an important candidate gene for bipolar disorder. ..
  3. Azzouz T, Schumperli D. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. RNA. 2003;9:1532-41 pubmed
    ..Therefore, Drosophila appears to be a suitable system for further genetic studies of the cell biology of U7 snRNPs. ..
  4. Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Maekawa M, Yoshikawa T. Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2. Neurosci Res. 2010;67:86-94 pubmed publisher
    ..In favor of this idea, IMPA2 encoding IMPase is a candidate susceptibility gene for bipolar disorder and that the risk-conferring single ..
  5. French D, Yang W, Cheng C, Raimondi S, Mullighan C, Downing J, et al. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood. 2009;113:4512-20 pubmed publisher
    ..Seven genes (FHOD3, IMPA2, ME2, RASSF4, SLC39A6, SMAD2, and SMAD4) displayed all 3 types of genomic variation associated with MTXPGs (P < ..
  6. Yoshikawa T, Padigaru M, Karkera J, Sharma M, Berrettini W, Esterling L, et al. Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2). Mol Psychiatry. 2000;5:165-71 pubmed
    Recently, we cloned the human myo-inositol monophosphatase 2 (IMPA2) cDNA and established its map location to chromosome 18p11.2, a region previously implicated in bipolar disorder...
  7. Ma Q, Yang Y, Na Y, Jin T, Xue Y, Shi Y, et al. IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population. Oncotarget. 2016;7:75273-75278 pubmed publisher
    Genetic association analysis has suggested that IMPA2 is a susceptibility gene for ischemic stroke (IS)...
  8. Yoshikawa T, Kikuchi M, Saito K, Watanabe A, Yamada K, Shibuya H, et al. Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. Mol Psychiatry. 2001;6:202-10 pubmed
    In our search for candidate genes for affective disorder on the short arm of chromosome 18, we cloned IMPA2, a previously unreported myo-inositol monophosphatase gene, that maps to 18p11.2...
  9. Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, et al. Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. Proteins. 2007;67:732-42 pubmed
    The human IMPA2 gene, which encodes myo-inositol monophosphatase 2 (IMPA2), is mapped onto 18p11.2, a susceptibility region for bipolar disorder...
  10. Sjøholt G, Ebstein R, Lie R, Berle J, Mallet J, Deleuze J, et al. Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder. Mol Psychiatry. 2004;9:621-9 pubmed
    ..13-21.3 and myo-inositol monophosphatase 2 (IMPA2) on chromosome 18p11.2...
  11. Yoon I, Li P, Siu K, Kennedy J, Cooke R, Parikh S, et al. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Mol Psychiatry. 2001;6:678-83 pubmed
    ..b>IMPA2 mRNA levels were significantly lower in BLCLs from male BD-I patients with high [Ca(2+)](B) (n = 6) compared with ..
  12. Ohnishi T, Ohba H, Seo K, Im J, Sato Y, Iwayama Y, et al. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007;282:637-46 pubmed
    ..have been identified in mammals, the well characterized myo-inositol monophosphatase 1 (IMPA1) and myo-inositol monophosphatase 2 (IMPA2)...
  13. Nakayama J, Yamamoto N, Hamano K, Iwasaki N, Ohta M, Nakahara S, et al. Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18. Neurology. 2004;63:1803-7 pubmed
    ..2 (non-parametric linkage score = 3.68, p = 0.0001). This region includes the IMPA2 gene, which encodes myo-inositol monophosphatase (IMPase) 2...
  14. Fujita S, Ohnishi T, Okuda S, Kobayashi R, Fukuno S, Furuta D, et al. In silico study on the substrate binding manner in human myo-inositol monophosphatase 2. J Mol Model. 2011;17:2559-67 pubmed publisher
    The human IMPA2 gene encoding myo-inositol monophosphatase 2 is highly implicated with bipolar disorder but the substrates and the reaction mechanism of myo-inositol monophosphatase 2 have not been well elucidated...
  15. Sjøholt G, Gulbrandsen A, Løvlie R, Berle J, Molven A, Steen V. A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients. Mol Psychiatry. 2000;5:172-80 pubmed
    ..Two genes encoding human IMPases have so far been isolated, namely IMPA1 on chromosome 8q21. 13-21.3 and IMPA2 on chromosome 18p11.2...