IMMT

Summary

Gene Symbol: IMMT
Description: inner membrane mitochondrial protein
Alias: HMP, MINOS2, Mic60, P87, P87/89, P89, PIG4, PIG52, MICOS complex subunit MIC60, cell proliferation-inducing gene 4/52 protein, cell proliferation-inducing protein 52, heart muscle protein, mitochondrial inner membrane organizing system 2, mitochondrial inner membrane protein, mitofilin, motor protein, proliferation-inducing gene 4
Species: human
Products:     IMMT

Top Publications

  1. Icho T, Ikeda T, Matsumoto Y, Hanaoka F, Kaji K, Tsuchida N. A novel human gene that is preferentially transcribed in heart muscle. Gene. 1994;144:301-6 pubmed
    ..In the middle of the sequence is a long stretch of alpha-helical residues that could form a coiled-coil. These features imply that this is a sequence encoding a new human motor protein.
  2. Gieffers C, Korioth F, Heimann P, Ungermann C, Frey J. Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms. Exp Cell Res. 1997;232:395-9 pubmed
    Mitofilin, also known as heart muscle protein, is a recently identified mitochondrial protein. We have isolated two human cDNAs that encode different isoforms of mitofilin...
  3. John G, Shang Y, Li L, Renken C, Mannella C, Selker J, et al. The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell. 2005;16:1543-54 pubmed
    ..Here, we demonstrate that mitofilin, a previously identified mitochondrial protein of unknown function, controls mitochondrial cristae morphology...
  4. Darshi M, Mendiola V, Mackey M, Murphy A, Koller A, Perkins G, et al. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011;286:2918-32 pubmed publisher
    ..Analysis of the ChChd3-binding proteins revealed that ChChd3 interacts with the IM proteins mitofilin and OPA1, which regulate crista morphology, and the outer membrane protein Sam50, which regulates import and ..
  5. An J, Shi J, He Q, Lui K, Liu Y, Huang Y, et al. CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. J Biol Chem. 2012;287:7411-26 pubmed publisher
    ..CHCM1/CHCHD6 through its C-terminal end strongly and directly interacts with the mitochondrial inner membrane protein mitofilin, which is known to also control mitochondrial cristae morphology...
  6. Weber T, Koob S, Heide H, Wittig I, Head B, VAN DER BLIEK A, et al. APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria. PLoS ONE. 2013;8:e63683 pubmed publisher
    ..we identified apolipoprotein O (APOO) and apolipoprotein O-like protein (APOOL) as putative components of the Mitofilin/MINOS protein complex which was recently implicated in determining cristae morphology...
  7. Xie J, Marusich M, Souda P, Whitelegge J, Capaldi R. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett. 2007;581:3545-9 pubmed
    A monoclonal antibody (mAb) has been produced which reacts with human mitofilin, a mitochondrial inner membrane protein. This mAb immunocaptures its target protein in association with six other proteins, metaxins 1 and 2, SAM50, CHCHD3, ..
  8. Park Y, Jeong J, Lee H, Mun J, Kim J, Lee J, et al. Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A. 2010;107:17785-90 pubmed publisher
    ..In this study, we characterized Mitofilin, a mitochondrial inner membrane protein, as a mediator of the mitochondrial function of DISC1...
  9. Yang R, Zhao G, Liang S, Zhang Y, Sun L, Chen H, et al. Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling. Biochem Biophys Res Commun. 2012;428:93-8 pubmed publisher
    ..Our studies demonstrated that mitofilin, a mitochondrial inner membrane protein, acted as a cristae controller to regulate cytochrome c release during apoptosis...

More Information

Publications128 found, 100 shown here

  1. Zhang Y, Xu J, Luo Y, An X, Zhang R, Liu G, et al. Overexpression of mitofilin in the mouse heart promotes cardiac hypertrophy in response to hypertrophic stimuli. Antioxid Redox Signal. 2014;21:1693-707 pubmed publisher
    Mitofilin was originally described as a heart muscle protein because of its abundance in the heart tissue; however, its function in the heart is still to be elucidated...
  2. Zhang D, Gao X, Zhao Y, Hou C, Zhu J. The C-terminal kinesin motor KIFC1 may participate in nuclear reshaping and flagellum formation during spermiogenesis of Larimichthys crocea. Fish Physiol Biochem. 2017;43:1351-1371 pubmed publisher
    ..KIFC1 is a C-terminal kinesin motor protein that plays an essential role in acrosome formation and nuclear reshaping during spermiogenesis in mammals...
  3. Zhao W, Jardine P, Grimes S. An RNA Domain Imparts Specificity and Selectivity to a Viral DNA Packaging Motor. J Virol. 2015;89:12457-66 pubmed publisher
    ..double-stranded DNA phages in having an RNA motor component, the function provided by pRNA is carried on the motor protein components in other phages...
  4. Zhang J, Oh E, Merz K, Aslamy A, Veluthakal R, Salunkhe V, et al. DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle. Diabetologia. 2019;62:845-859 pubmed publisher
    ..identified that DOC2B is phosphorylated on insulin stimulation, enhancing its interaction with a microtubule motor protein, kinesin light chain 1 (KLC1)...
  5. Sirohi K, Swarup G. Defects in autophagy caused by glaucoma-associated mutations in optineurin. Exp Eye Res. 2016;144:54-63 pubmed publisher
    ..Optineurin interacts with a motor protein, myosinVI, and this interaction is involved in mediating fusion of autophagosomes with lysosomes...
  6. Majewski L, Nowak J, Sobczak M, Karatsai O, Havrylov S, Lenartowski R, et al. Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins. Nucleus. 2018;9:125-141 pubmed publisher
    Myosin VI (MVI) is a unique actin-based motor protein moving towards the minus end of actin filaments, in the opposite direction than other known myosins...
  7. Ames N, Barb J, Ranucci A, Kim H, Mudra S, Cashion A, et al. The oral microbiome of patients undergoing treatment for severe aplastic anemia: a pilot study. Ann Hematol. 2019;: pubmed publisher
    ..we compared our findings to tongue dorsum samples from healthy participants in the Human Microbiome Project (HMP) database and found among HSCT patients, approximately 35% of bacterial identifiers (N = 229) were unique to ..
  8. Ramirez Sanchez I, Mansour C, Navarrete Yañez V, Ayala Hernandez M, Guevara G, Castillo C, et al. (-)-Epicatechin induced reversal of endothelial cell aging and improved vascular function: underlying mechanisms. Food Funct. 2018;9:4802-4813 pubmed publisher
    ..Phosphorylated sirtuin-1, mitofilin, oxidative phosphorylation complexes and transcriptional factor for mitochondria were reduced by ∼40% with ..
  9. Lee S, Olsen T, Vinknes K, Refsum H, Gulseth H, Birkeland K, et al. Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men. Nutrients. 2018;11: pubmed publisher
    ..acid metabolism in both skeletal muscle and adipose tissue, as well as mitochondria-related genes such as mitofilin...
  10. Bousquet A, Henquet S, Compain F, Genel N, Arlet G, Decré D. Partition locus-based classification of selected plasmids in Klebsiella pneumoniae, Escherichia coli and Salmonella enterica spp.: an additional tool. J Microbiol Methods. 2015;110:85-91 pubmed publisher
    ..e. a centromere like DNA site, a centromere-binding protein and an ATPase or a GTPase motor protein for plasmid positioning...
  11. Chaudhury A, Cristofaro V, Carew J, Goyal R, Sullivan M. Myosin Va plays a role in nitrergic smooth muscle relaxation in gastric fundus and corpora cavernosa of penis. PLoS ONE. 2014;9:e86778 pubmed publisher
    The intracellular motor protein myosin Va is involved in nitrergic neurotransmission possibly by trafficking of neuronal nitric oxide synthase (nNOS) within the nerve terminals...
  12. Maddirevula S, Alhebbi H, Alqahtani A, Algoufi T, Alsaif H, Ibrahim N, et al. Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants. Genet Med. 2018;: pubmed publisher
    ..KIF12, which encodes a microtubule motor protein with a tentative role in cell polarity, was found to harbor three homozygous likely deleterious variants in ..
  13. Andringa K, Udoh U, Landar A, Bailey S. Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats. Redox Biol. 2014;2:1038-47 pubmed publisher
    ..IEF/SDS-PAGE and BN-PAGE) we identified several mitochondrial proteins immunoreactive for 4-HNE, which included mitofilin, dimethylglycine dehydrogenase, choline dehydrogenase, electron transfer flavoprotein α, cytochrome c1, enoyl ..
  14. Chai Y, Dang G, He H, Shi J, Zhang H, Zhang R, et al. Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model. World J Gastroenterol. 2017;23:7221-7231 pubmed publisher
    ..standard and marginal liver grafts of young and aged rats ex vivo by hypothermic machine perfusion (HMP)...
  15. Rossor A, Oates E, Salter H, Liu Y, Murphy S, Schule R, et al. Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2. Brain. 2015;138:293-310 pubmed publisher
    ..reduced numbers of lumbar motor neurons and is caused by mutations in DYNC1H1, which encodes a microtubule motor protein in the dynein-dynactin complex and one of its cargo adaptors, BICD2...
  16. Guido B, Ramos L, Nolasco D, Nobrega C, Andrade B, Pic Taylor A, et al. Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features. BMC Cancer. 2015;15:283 pubmed publisher
    ..We identified five DHPMs with pronounced inhibitory activity on Eg5 motor protein interfering with the proper mitotic spindle assembly during cell division...
  17. Fellows J, Cipriano M, Agrawal S, Striepen B. A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii. MBio. 2017;8: pubmed publisher
    ..protein (PUBL) which is a novel ubiquitin-like protein and demonstrate its importance and that of the motor protein CDC48AP for apicoplast protein import...
  18. Suzuki T, Yamaguchi H, Kikusato M, Hashizume O, Nagatoishi S, Matsuo A, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016;27:1925-32 pubmed publisher
    ..Additional assays revealed that MA-5 targets the mitochondrial protein mitofilin at the crista junction of the inner membrane...
  19. Westbroek W, Tuchman M, Tinloy B, De Wever O, Vilboux T, Hertz J, et al. A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome. Mol Genet Metab. 2008;94:248-54 pubmed publisher
    ..Once attached, Rab27A recruits the downstream effector Melanophilin (Mlph) and the actin-dependent motor protein Myosin Va (MyoVa)...
  20. Hou S, Li N, Zhang Q, Li H, Wei X, Hao T, et al. XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE. Cell Death Dis. 2016;7:e2409 pubmed publisher
    ..Among top genes down-regulated by XAB2 depletion is mitotic motor protein centrosome-associated protein E (CENPE)...
  21. Xue R, Yu X, Zhao M, Xu M, Wu Q, Cui Y, et al. Pyridostigmine alleviates cardiac dysfunction via improving mitochondrial cristae shape in a mouse model of metabolic syndrome. Free Radic Biol Med. 2019;134:119-132 pubmed publisher
    ..Specifically, PYR upregulated OPA1 and Mfn1/2 expression, promoted the formation of the mitofilin/CHCHD3/Sam50 complex, and decreased p-Drp1 and Fis1 expression, resulting in tight and parallel cristae and ..
  22. Fitzsimmons L, Liu L, Kim J, Jones Carson J, Vazquez Torres A. Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress. MBio. 2018;9: pubmed publisher
    ..branched-chain amino acid biosynthesis that enables the translation of the NO-consuming flavohemoglobin Hmp. Guanosine tetraphosphate synthesized by RelA protects salmonellae from the metabolic stress inflicted by reactive ..
  23. Neupert C, Schneider R, Klatt O, Reissner C, Repetto D, Biermann B, et al. Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals. J Neurosci. 2015;35:13629-47 pubmed publisher
    ..transport of βNrxn(+) STVs was faster than that of αNrxns, but both depended on the microtubule motor protein KIF1A and neuronal activity regulated the velocity...
  24. Sun Y, De Vos P, Heylen K. Nitrous oxide emission by the non-denitrifying, nitrate ammonifier Bacillus licheniformis. BMC Genomics. 2016;17:68 pubmed publisher
    ..nitrous oxide emitters, hypothetical pathways for nitrous oxide production, involving NarG, NirB, qNor and Hmp, are proposed. In addition, all publically available genomes of B...
  25. Deissler H, Lang G, Lang G. Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation. Graefes Arch Clin Exp Ophthalmol. 2019;257:83-94 pubmed publisher
    ..Aflibercept-specific perinuclear staining overlapped with that of the motor protein dynein whereas double staining with an anti-kinesin antibody resulted in a patchy pattern...
  26. Jiang S, Chen G, Feng L, Jiang Z, Yu M, Bao J, et al. Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway. Mol Med Rep. 2016;14:1891-900 pubmed publisher
    The anterograde intraflagellar transport motor protein, kif3a, regulates the integrity of primary cilia and various cellular functions, however, the role of kif3a in dental mesenchymal stem/precursor cell differentiation remains to be ..
  27. Mohari B, Licata N, Kysela D, Merritt P, Mukhopadhay S, Brun Y, et al. Novel pseudotaxis mechanisms improve migration of straight-swimming bacterial mutants through a porous environment. MBio. 2015;6:e00005 pubmed publisher
    ..but it can also be found less frequently to be due to mutations in the hook length regulator, FliK, or in the motor protein, MotA...
  28. Doumatey A, Xu H, Huang H, Trivedi N, Lei L, Elkahloun A, et al. Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans. J Endocrinol Metab. 2015;5:199-210 pubmed
    ..i>MYO10 encodes for an actin-based motor protein that has been associated with T2D...
  29. Camlin N, McLaughlin E, Holt J. Kif4 Is Essential for Mouse Oocyte Meiosis. PLoS ONE. 2017;12:e0170650 pubmed publisher
    ..During mitosis, the kinesin motor protein Kif4 is indispensable for chromosome condensation and separation, midzone formation and cytokinesis...
  30. Petrosyan A, Ali M, Cheng P. Keratin 1 plays a critical role in golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail. J Biol Chem. 2015;290:6256-69 pubmed publisher
    ..that C2GnT-M targets the Golgi at the Giantin site and is recycled by binding to non-muscle myosin IIA, a motor protein, via the cytoplasmic tail (CT). But how this enzyme is retained in the Golgi is not known...
  31. Schopp I, Reissberg E, Lüer B, Efferz P, Minor T. Controlled Rewarming after Hypothermia: Adding a New Principle to Renal Preservation. Clin Transl Sci. 2015;8:475-8 pubmed publisher
    ..Porcine kidneys were subjected either to 18 hours of hypothermic machine preservation (HMP) or 18 hours static cold storage + 3 hours of gentle, machine controlled oxygenated rewarming (COR)...
  32. Yang Z, Zhong Z, Li M, Xiong Y, Wang Y, Peng G, et al. Hypothermic machine perfusion increases A20 expression which protects renal cells against ischemia/reperfusion injury by suppressing inflammation, apoptosis and necroptosis. Int J Mol Med. 2016;38:161-71 pubmed publisher
    ..protects renal cells against ischemia/reperfusion injury (IRI) following either hypothermic machine perfusion (HMP) or static cold storage (CS) of the kidneys in a rabbit model...
  33. López Doménech G, Covill Cooke C, Ivankovic D, Halff E, Sheehan D, Norkett R, et al. Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution. EMBO J. 2018;37:321-336 pubmed publisher
    ..Unexpectedly, the TRAK1 and TRAK2 motor protein adaptors can still localise to the outer mitochondrial membrane to drive anterograde mitochondrial motility in ..
  34. Lehti M, Kotaja N, Sironen A. KIF1-binding protein interacts with KIF3A in haploid male germ cells. Reproduction. 2015;150:209-16 pubmed publisher
    ..Previously, we have demonstrated that a microtubule-based anterograde transport motor protein KIF3A is required for the sperm tail formation and nuclear shaping during spermatogenesis...
  35. Wei J, Graziane N, Gu Z, Yan Z. DISC1 Protein Regulates γ-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons. J Biol Chem. 2015;290:27680-7 pubmed publisher
    ..Moreover, the regulation of GABAARs by DISC1 knockdown or overexpression depends on the microtubule motor protein kinesin 1 (KIF5)...
  36. Kim H, Johnson J, Lera R, Brahma S, Burkard M. Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis. PLoS Genet. 2017;13:e1006511 pubmed publisher
    ..This ring is composed of filamentous actin and the motor protein myosin, along with additional structural and regulatory proteins, including anillin...
  37. Perez Garcia O, Chandran K, Villas Boas S, Singhal N. Assessment of nitric oxide (NO) redox reactions contribution to nitrous oxide (N2 O) formation during nitrification using a multispecies metabolic network model. Biotechnol Bioeng. 2016;113:1124-36 pubmed publisher
    ..e., P460 [CytP460] and 554 [Cyt554 ]) and flavohemoglobins (Hmp) in ammonia- and nitrite-oxidizing bacteria (AOB and NOB, respectively)...
  38. Heilig C, Kreisberg J, Freytag S, Murakami T, Ebina Y, Guo L, et al. Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression. Am J Physiol Renal Physiol. 2001;280:F657-66 pubmed
    ..no increase in MCGT1AS. Glucose (8 mM) and 12 mM xylitol [a hexose monophosphate (HMP) shunt substrate] did not stimulate GLUT-1 transcription...
  39. Courchesne S, Pazyra Murphy M, Lee D, Segal R. Neuromuscular junction defects in mice with mutation of dynein heavy chain 1. PLoS ONE. 2011;6:e16753 pubmed publisher
    ..mice, with hypomorphic mutations in the dynein heavy chain 1 gene, which encodes the ATPase of the retrograde motor protein dynein, were originally reported to exhibit late onset motor neuron disease...
  40. Conceição J, Delbem A, Danelon M, da Camara D, Wiegand A, Pessan J. Fluoride gel supplemented with sodium hexametaphosphate reduces enamel erosive wear in situ. J Dent. 2015;43:1255-60 pubmed publisher
    This study evaluated the effect of fluoride gels, supplemented or not with sodium hexametaphosphate (HMP), on enamel erosive wear in situ. Twelve healthy volunteers wore palatal appliances containing four bovine enamel discs...
  41. Kulashreshtha M, Mehta I, Kumar P, Rao B. Chromosome territory relocation during DNA repair requires nuclear myosin 1 recruitment to chromatin mediated by Ï’-H2AX signaling. Nucleic Acids Res. 2016;44:8272-91 pubmed publisher
    ..Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1) ensues, which appears to be functionally linked to Ï’-H2AX signaling...
  42. Beaudoin G, Johnson T, Hanson A. The PLUTO plastidial nucleobase transporter also transports the thiamin precursor hydroxymethylpyrimidine. Biosci Rep. 2018;38: pubmed publisher
    In plants, the hydroxymethylpyrimidine (HMP) and thiazole precursors of thiamin are synthesized and coupled together to form thiamin in plastids...
  43. Kuźma Kozakiewicz M, Kaźmierczak B, Chudy A, Gajewska B, Barańczyk Kuźma A. Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. Neurodegener Dis. 2016;16:235-44 pubmed publisher
    ..In SALS, and especially in classic ALS, the changes in motor protein expression may alter bidirectional intracellular transport in PBMCs...
  44. Choi M, Jo S, Lee B, Kim M, Choi J, Kim K, et al. Dynamic characteristics of a flagellar motor protein analyzed using an elastic network model. J Mol Graph Model. 2017;78:81-87 pubmed publisher
    ..dynamic properties as well as conformational changes is a key to understanding the switching mechanism of the motor protein. In this study, to elucidate dynamic characteristics of the C-ring structure, both harmonic (intrinsic ..
  45. Hazra S, Henderson J, Liles K, Hilton M, Wachter R. Regulation of ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) activase: product inhibition, cooperativity, and magnesium activation. J Biol Chem. 2015;290:24222-36 pubmed publisher
    In many photosynthetic organisms, tight-binding Rubisco inhibitors are released by the motor protein Rubisco activase (Rca). In higher plants, Rca plays a pivotal role in regulating CO2 fixation. Here, the ATPase activity of 0...
  46. Brunsch M, Schubert D, Gube M, Ring C, Hänisch L, Linde J, et al. Dynein Heavy Chain, Encoded by Two Genes in Agaricomycetes, Is Required for Nuclear Migration in Schizophyllum commune. PLoS ONE. 2015;10:e0135616 pubmed publisher
    ..For this transport activity, the motor protein dynein is required. In S...
  47. Bendadani C, Steinhauser L, Albert K, Glatt H, Monien B. Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats. Toxicology. 2016;366-367:43-52 pubmed publisher
    ..hydrocarbon and environmental carcinogen, is activated by side-chain hydroxylation to 1-hydroxymethylpyrene (1-HMP) and subsequent sulfo conjugation to the DNA-reactive 1-sulfooxymethylpyrene...
  48. Jones Carson J, Husain M, Liu L, Orlicky D, Vazquez Torres A. Cytochrome bd-Dependent Bioenergetics and Antinitrosative Defenses in Salmonella Pathogenesis. MBio. 2016;7: pubmed publisher
    ..The combined antinitrosative defenses of cytochrome bd and the flavohemoglobin Hmp account for a great part of the adaptations that help Salmonella recover from the antimicrobial activity of NO...
  49. Srivastava V, Raikwar S, Tuteja R, Tuteja N. Ectopic expression of phloem motor protein pea forisome PsSEO-F1 enhances salinity stress tolerance in tobacco. Plant Cell Rep. 2016;35:1021-41 pubmed publisher
    ..This finding should make an important contribution in our better understanding of the significance of calcium signaling in phloem tissue leading to salinity stress tolerance. ..
  50. Katsuyama Y, Taira N, Yoshioka M, Okano Y, Masaki H. Disruption of melanosome transport in melanocytes treated with theophylline causes their degradation by autophagy. Biochem Biophys Res Commun. 2017;485:126-130 pubmed publisher
    ..In this study, we disrupted melanosome transport by knockdown of the motor protein MyosinVa...
  51. Debattisti V, Gerencser A, Saotome M, Das S, Hajnoczky G. ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak. Cell Rep. 2017;21:1667-1680 pubmed publisher
    ..directly to kinesins without involvement of the physiological adaptors between the organelles and the motor protein prevents the H2O2-induced decrease in mitochondrial motility...
  52. Wang D, Zhu L, Liao M, Zeng T, Zhuo W, Yang S, et al. MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40. Oncol Rep. 2016;36:1285-92 pubmed publisher
    ..Myosin VI (MYO6), as a motor protein, has been reported to be implicated in cancer-related cell migration and cellular functions...
  53. Saiardi A. Protein pyrophosphorylation: moving forward. Biochem J. 2016;473:3765-3768 pubmed
    ..In particular, the vesicular transport along the microtubule that is driven by the motor protein complex dynein...
  54. Son G, Kim D, Lee J, Kim H, Lee C, Kim S, et al. Synchronized methylene blue removal using Fenton-like reaction induced by phosphorous oxoanion and submerged plasma irradiation process. J Environ Manage. 2018;206:77-84 pubmed publisher
    ..SPI system has a higher dye removal efficiency than a tetrasodium pyrophosphate (DP) or a sodium hexametaphosphate (HMP) combined SPI system under similar dissolved iron ion concentrations...
  55. Raidt J, Werner C, Menchen T, Dougherty G, Olbrich H, Loges N, et al. Ciliary function and motor protein composition of human fallopian tubes. Hum Reprod. 2015;30:2871-80 pubmed publisher
    What is the motor protein composition and function of human fallopian tube (FT) cilia? Although the motor protein composition and function of human FT cilia resemble that of respiratory cilia, females with primary ciliary dyskinesia (PCD)..
  56. Hockenberry A, Hutchens D, Agellon A, So M. Attenuation of the Type IV Pilus Retraction Motor Influences Neisseria gonorrhoeae Social and Infection Behavior. MBio. 2016;7: pubmed publisher
    ..date, investigations into Tfp retraction-dependent activities have used a mutant deleted of PilT, the ATPase motor protein that causes the pilus fiber to retract...
  57. Jolly A, Luan C, Dusel B, Dunne S, Winding M, Dixit V, et al. A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells. Cell Rep. 2016;14:611-620 pubmed publisher
    ..system to monitor lysosome transport along microtubule bundles, which require enzymatically active kinesin-1 motor protein for their formation...
  58. Stevenson J, Conaty E, Walsh R, Poidomani P, Samoriski C, Scollins B, et al. The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner. PLoS ONE. 2016;11:e0147808 pubmed publisher
    ..with microtubules is an ATP dependent process suggesting that the APP-organelles contain a microtubule-based motor protein. Although a direct kinesin/APP association remains controversial, the distribution of APP at the organelle/..
  59. Liu J, Du J, Yang Y, Wang Y. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015;273:253-62 pubmed publisher
    ..reduced the interaction of TRPV1 with the cytoskeletal elements and decreased the binding of TRPV1 with the motor protein KIF13B, which led to reduced surface distribution of TRPV1...
  60. Tigchelaar W, de Jong A, Bloks V, van Gilst W, de Boer R, Silljé H. Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2016;97:70-81 pubmed publisher
    ..major differences in gene expression of mitochondrial encoding proteins, but we identified a gene encoding a motor protein implicated in mitochondrial localization, kinesin family member 5b (Kif5b), which was clearly elevated in PE ..
  61. Hang J, Pan W, Chang A, Li S, Li C, Fu M, et al. Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats. Neural Plast. 2016;2016:4545826 pubmed publisher
    Prestin is the motor protein expressed in the cochlear outer hair cells (OHCs) of mammalian inner ear...
  62. Kudumala S, Penserga T, Börner J, Slipchuk O, Kakad P, Lee L, et al. Lissencephaly-1 dependent axonal retrograde transport of L1-type CAM Neuroglian in the adult drosophila central nervous system. PLoS ONE. 2017;12:e0183605 pubmed publisher
    ..transported, we inhibited two key regulators, Lissencephaly-1 (Lis1) and Dynactin, of the retrograde motor protein Dynein...
  63. Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, et al. Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer. 2015;15:961 pubmed publisher
    KIF23 (kinesin family member 23) is a kinesin-like motor protein and plays an important role in cytokinesis...
  64. Onaka A, Toyofuku N, Inoue T, Okita A, Sagawa M, Su J, et al. Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation. Nucleic Acids Res. 2016;44:10744-10757 pubmed
    ..Here, we provide evidence that Rad51 with the aid of the Swi/Snf-type motor protein Rad54 promotes non-crossover recombination between centromere repeats to prevent isochromosome formation...
  65. Miyanoiri Y, Hijikata A, Nishino Y, Gohara M, Onoue Y, Kojima S, et al. Structural and Functional Analysis of the C-Terminal Region of FliG, an Essential Motor Component of Vibrio Na+-Driven Flagella. Structure. 2017;25:1540-1548.e3 pubmed publisher
    The flagellar motor protein complex consists of rotor and stator proteins. Their interaction generates torque of flagellum, which rotates bidirectionally, clockwise (CW) and counterclockwise...
  66. Sandu P, Crepin V, Drechsler H, McAinsh A, Frankel G, Berger C. The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner. Infect Immun. 2017;85: pubmed publisher
    ..Furthermore, using a yeast two-hybrid screen, we identified the motor protein Kif15 as a potential interacting partner of EspW...
  67. Kondo M. Molecular mechanisms of experience-dependent structural and functional plasticity in the brain. Anat Sci Int. 2017;92:1-17 pubmed
    ..This review consists of three parts: first, a description of a role for the motor protein KIF1A in enhanced synaptogenesis and memory function induced by environmental enrichment; second, a discussion ..
  68. Hettiaratchi M, Rouse T, Chou C, Krishnan L, Stevens H, Li M, et al. Enhanced in vivo retention of low dose BMP-2 via heparin microparticle delivery does not accelerate bone healing in a critically sized femoral defect. Acta Biomater. 2017;59:21-32 pubmed publisher
    ..The model suggested that HMPs limited BMP-2 release into surrounding tissues, and that changing the HMP density could modulate BMP-2 release...
  69. Blum M, Liu Q, Soliman B, Dreher P, Okamoto T, Poggio E, et al. Comparison of normothermic and hypothermic perfusion in porcine kidneys donated after cardiac death. J Surg Res. 2017;216:35-45 pubmed publisher
    ..The relative efficacy of prolonged NMP compared to hypothermic machine perfusion (HMP) in DCD kidneys with moderate ischemic injury is undetermined...
  70. Camargo L, Collura V, Rain J, Mizuguchi K, Hermjakob H, Kerrien S, et al. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry. 2007;12:74-86 pubmed
  71. Fisher S. Smooth Muscle Phenotypic Diversity: Effect on Vascular Function and Drug Responses. Adv Pharmacol. 2017;78:383-415 pubmed publisher
    ..of the myosin kinase and phosphatase determining the phosphorylation and activity of the myosin ATPase motor protein. In contrast, the vascular system of humans and other mammals is incredibly complex and highly regulated...
  72. Smith T. Biogenetic Relationships of Bioactive Sponge Merotriterpenoids. Mar Drugs. 2017;15: pubmed publisher
    ..an in depth structural analysis of sponge merotriterpenoids, including the adociasulfate family of kinesin motor protein inhibitors, provides insight into their biosynthesis...
  73. Hares K, Miners J, Cook A, Rice C, Scolding N, Love S, et al. Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease. J Alzheimers Dis. 2017;60:1511-1524 pubmed publisher
    Defects in motor protein-mediated neuronal transport mechanisms have been implicated in a number of neurodegenerative disorders but remain relatively little studied in Alzheimer's disease (AD)...
  74. Genin E, Plutino M, Bannwarth S, Villa E, Cisneros Barroso E, Roy M, et al. CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. EMBO Mol Med. 2016;8:58-72 pubmed publisher
    ..Here, we show that CHCHD10 resides with mitofilin, CHCHD3 and CHCHD6 within the "mitochondrial contact site and cristae organizing system" (MICOS) complex...
  75. Gowers G, Robinson J, Brynildsen M. Starved Escherichia coli preserve reducing power under nitric oxide stress. Biochem Biophys Res Commun. 2016;476:29-34 pubmed publisher
    ..both carbon source limitation and starvation, and those failures could have arisen from inabilities to synthesize Hmp (NOD of E. coli) and/or supply it with sufficient NADH (preferred electron donor)...
  76. Raei M, Shahidi F, Farhoodi M, Jafari S, Rafe A. Application of whey protein-pectin nano-complex carriers for loading of lactoferrin. Int J Biol Macromol. 2017;105:281-291 pubmed publisher
    Our aim was to entrap lactoferrin (LF) in complex nano-particles of whey protein isolate (WPI)-high methoxyl pectin (HMP) with the ratios of 2:1, 1:1, and 1:2 through acidification at pH values of 3, 3.5, and 4...
  77. Capone E, Piccolo E, Fichera I, Ciufici P, Barcaroli D, Sala A, et al. Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma. Oncotarget. 2017;8:60368-60377 pubmed publisher
    ..It consists of a humanized endosialin monoclonal antibody, named hMP-E-8.3, conjugated to a potent duocarmycin derivative...
  78. Park H, Ma Z, Zhu H, Jiang S, Robinson R, Endow S. Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. Sci Rep. 2017;7:15121 pubmed publisher
    ..This selectivity can be explained by unique structural features of the KIFC1 ?4/?6 binding site. These features may help improve the drug-like properties of AZ82 and other specific KIFC1 inhibitors. ..
  79. Landrock K, Sullivan P, Martini Stoica H, Goldstein D, Graham B, Yamamoto S, et al. Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. Brain Res. 2018;1679:155-170 pubmed publisher
    ..Myo5a encodes a myosin motor protein required for transport and proper distribution of subcellular organelles in somatodendritic processes in ..
  80. Rossi M, Carbone M, Mostocotto C, Mancone C, Tripodi M, Maione R, et al. Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity. J Biol Chem. 2009;284:31616-24 pubmed publisher
    ..Through a proteomic analysis of PARP-1 co-immunoprecipitation complexes, we identified Mitofilin, a mitochondrial protein, as a new PARP-1 interactor...
  81. Guarani V, McNeill E, Paulo J, Huttlin E, Fröhlich F, Gygi S, et al. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
    ..Using quantitative proteomics, we show that loss of QIL1 resulted in MICOS disassembly with the accumulation of a MIC60-MIC19-MIC25 sub-complex and degradation of MIC10, MIC26, and MIC27...
  82. Yamashita T, Hakizimana P, Wu S, Hassan A, Jacob S, Temirov J, et al. Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins. PLoS Genet. 2015;11:e1005500 pubmed publisher
    ..Previous studies suggest that Slc26a5 continuously diffuses within the membrane, but how can a freely moving motor protein effectively convey forces critical for hearing? To provide direct evidence in OHCs for freely moving Slc26a5 ..
  83. Allen W, Corey R, Oatley P, Sessions R, Baldwin S, Radford S, et al. Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation. elife. 2016;5: pubmed publisher
    ..The model represents a solution to the problem of transporting inherently variable substrates such as polypeptides, and may underlie mechanisms of other motors that translocate proteins and nucleic acids. ..
  84. Jiang X, Hu X, Xu W. Microbiome Data Representation by Joint Nonnegative Matrix Factorization with Laplacian Regularization. IEEE/ACM Trans Comput Biol Bioinform. 2017;14:353-359 pubmed publisher
    ..joint non-negative matrix factorization (LJ-NMF) for integrating functional and phylogenetic profiles from HMP. We compare the performance of this method to other variants of NMF...
  85. Tsuji M, Rashedul Kabir A, Ito M, Inoue D, Kokado K, Sada K, et al. Motility of Microtubules on the Inner Surface of Water-in-Oil Emulsion Droplets. Langmuir. 2017;33:12108-12113 pubmed publisher
    ..A microtubule (MT)-associated motor protein kinesin-1 was successfully anchored to the inner surface of water-in-oil emulsion droplets by employing the ..
  86. Carvalho A, Lana T, Perfeito J, Silveira D. The Brazilian market of herbal medicinal products and the impacts of the new legislation on traditional medicines. J Ethnopharmacol. 2018;212:29-35 pubmed publisher
    the herbal medicinal products (HMP) market is expanding in the world, an expansion that has not occurred in Brazil when considering the number of licensed products...
  87. Juárez S, Ortiz Barreda G, Agudelo Suárez A, Ronda Pérez E. Revisiting the Healthy Migrant Paradox in Perinatal Health Outcomes Through a Scoping Review in a Recent Host Country. J Immigr Minor Health. 2017;19:205-214 pubmed publisher
    ..outcomes than natives despite facing socioeconomic disadvantages in the host country ("healthy migrant paradox" -HMP)...
  88. Wang Z, Zhang F, He J, Wu P, Tay L, Cai M, et al. Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Dev Cell. 2017;43:186-197.e7 pubmed publisher
    ..A liposome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein...
  89. Pan L, Zhang Y, Zhu C, Dong Z. Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein. J Zhejiang Univ Sci B. 2017;18:1046-1054 pubmed publisher
    ..Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along ..
  90. Feizabadi M, Jun Y, Reddy J. Distinctions between dynamic characteristics of the single EG5 motor protein along neural vs. cancerous microtubules. Biochem Biophys Res Commun. 2016;478:1630-3 pubmed publisher
    ..This finding is intriguing, as it suggests that, potentially, groups of Eg5 motors function more effectively in the cancer background of a large ensemble, possibly contributing to faster mitosis in cancer cells. ..
  91. Kaur M, Devi R, Ghosh T, Khan M, Kumar P, Priyanka -, et al. Sld5 Ensures Centrosomal Resistance to Congression Forces by Preserving Centriolar Satellites. Mol Cell Biol. 2018;38: pubmed publisher
    ..The minus-end-directed kinesin-14 motor protein, HSET, sustains the traction forces that mediate centrosomal fragmentation in Sld5-depleted cells...
  92. Almendro Vedia V, Natale P, Mell M, Bonneau S, Monroy F, Joubert F, et al. Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F1F0-ATP synthase. Proc Natl Acad Sci U S A. 2017;114:11291-11296 pubmed publisher