ILVBL

Summary

Gene Symbol: ILVBL
Description: ilvB acetolactate synthase like
Alias: 209L8, AHAS, HACL1L, ILV2H, acetolactate synthase-like protein, 2-hydroxyacyl-CoA lyase 1 like, acetolactate synthase homolog, ilvB (bacterial acetolactate synthase)-like, ilvB-like protein
Species: human
Products:     ILVBL

Top Publications

  1. Jain P, Tar an B. Analysis of acetohydroxyacid synthase1 gene in chickpea conferring resistance to imazamox herbicide. Genome. 2014;57:593-600 pubmed publisher
    ..In many plant species, contrasting transcription levels of AHAS gene has been implicated in the resistant and susceptible genotypes in response to IMI...
  2. Pandolfo C, Presotto A, Moreno F, Dossou I, Migasso J, Sakima E, et al. Broad resistance to acetohydroxyacid-synthase-inhibiting herbicides in feral radish (Raphanus sativus L.) populations from Argentina. Pest Manag Sci. 2016;72:354-61 pubmed publisher
    ..radish accessions were highly resistant to ten active ingredients of five families of acetohydroxyacid synthase (AHAS)-inhibiting herbicides...
  3. Gokhale K, Tilak B. Mechanisms of bacterial acetohydroxyacid synthase (AHAS) and specific inhibitors of Mycobacterium tuberculosis AHAS as potential drug candidates against tuberculosis. Curr Drug Targets. 2015;16:689-99 pubmed
    ..plants and fungi, the synthesis of Branched Chain Amino Acids (BCAAs) is catalyzed by Acetohydroxyacid Synthases (AHAS) group of enzymes. Bacterial AHAS (EC 2.2.1...
  4. Schwarz M, Ward E, Cornwell P, Coccetti A, Kalapac N. Evaluating the Feasibility and Validity of Using Trained Allied Health Assistants to Assist in Mealtime Monitoring of Dysphagic Patients. Dysphagia. 2018;: pubmed publisher
    ..The primary aim of this study was to explore the feasibility and initial validity of using trained AHAs to complete structured mealtime observations of patients...
  5. Garcia M, Chua S, Low Y, Lee Y, Agnew Francis K, Wang J, et al. Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc Natl Acad Sci U S A. 2018;115:E9649-E9658 pubmed publisher
    ..Here, we demonstrate that acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway, is a promising new target for antifungal ..
  6. Fartyal D, Agarwal A, James D, Borphukan B, Ram B, Sheri V, et al. Developing dual herbicide tolerant transgenic rice plants for sustainable weed management. Sci Rep. 2018;8:11598 pubmed publisher
    ..The herbicide tolerant mutant variant of rice AHAS (Acetohydroxyacid synthase) was overexpressed along with codon optimized bacterial bar gene...
  7. Li K, Qu R, Liu Y, Yang J, Devendar P, Chen Q, et al. Design, Synthesis, and Herbicidal Activity of Pyrimidine-Biphenyl Hybrids as Novel Acetohydroxyacid Synthase Inhibitors. J Agric Food Chem. 2018;66:3773-3782 pubmed publisher
    The issue of weed resistance to acetohydroxyacid synthase (EC 2.2.1.6, AHAS) inhibitors has become one of the largest obstacles for the application of this class of herbicides...
  8. Matzrafi M, Gadri Y, Frenkel E, Rubin B, Peleg Z. Evolution of herbicide resistance mechanisms in grass weeds. Plant Sci. 2014;229:43-52 pubmed publisher
    ..Wide screening of the responses of the accessions to four major herbicide groups (PSII, ACCase, ALS/AHAS and EPSPS inhibitors) identified 28 herbicide-resistance candidate accessions...
  9. Pawaskar M, Xu L, Tang Y, Puckrein G, Rajpathak S, Stuart B. Effect of Medication Copayment on Adherence and Discontinuation in Medicare Beneficiaries with Type 2 Diabetes: A Retrospective Administrative Claims Database Analysis. Diabetes Ther. 2018;: pubmed publisher
    Nonadherence to antihyperglycemic agents (AHAs) increases the incidence of morbidity and mortality, as well as healthcare-related costs, in patients with type 2 diabetes (T2D)...

More Information

Publications79

  1. Baig I, Moon J, Lee S, Ryoo S, Yoon M. Development of ssDNA aptamers as potent inhibitors of Mycobacterium tuberculosis acetohydroxyacid synthase. Biochim Biophys Acta. 2015;1854:1338-50 pubmed publisher
    Acetohydroxyacid synthase (AHAS) from Mycobacterium tuberculosis (Mtb) is a promising potential drug target for an emerging class of new anti-tuberculosis agents...
  2. Saika A, Ushimaru K, Mizuno S, Tsuge T. Genome-based analysis and gene dosage studies provide new insight into 3-hydroxy-4-methylvalerate biosynthesis in Ralstonia eutropha. J Bacteriol. 2015;197:1350-9 pubmed publisher
    ..ilvH encodes a subunit protein that regulates acetohydroxy acid synthase III (AHAS III)...
  3. Li X, Qie S, Wang X, Zheng Y, Liu Y, Liu G. The safety and efficacy of once-weekly glucagon-like peptide-1 receptor agonist semaglutide in patients with type 2 diabetes mellitus: a systemic review and meta-analysis. Endocrine. 2018;: pubmed publisher
    ..peptide-1 (GLP-1) receptor agonist semaglutide as monotherapy or add-on to other antihyperglycaemic agents (AHAs) in patients with type 2 diabetes mellitus (T2DM). PubMed, Embase, Cochrane library and ClinicalTrials...
  4. Tang S, Yang J. Dual Effects of Alpha-Hydroxy Acids on the Skin. Molecules. 2018;23: pubmed publisher
    b>AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations...
  5. Lu W, Baig I, Sun H, Cui C, Guo R, Jung I, et al. Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase. Eur J Med Chem. 2015;94:298-305 pubmed publisher
    Acetohydroxyacid synthase (AHAS) catalyzes the first essential biosynthetic step of branched-chain amino acids and is a biologically safe target against Mycobacterium tuberculosis (MTB)...
  6. Pue N, Guddat L. Acetohydroxyacid synthase: a target for antimicrobial drug discovery. Curr Pharm Des. 2014;20:740-53 pubmed
    Acetohydroxyacid synthase (AHAS) (EC 2.2.1.6) (also known as acetolactate synthase) is the first common enzyme in the branched chain amino acid (BCAA) biosynthesis pathway...
  7. Li H, Li J, Zhao B, Wang J, Yi L, Liu C, et al. Generation and characterization of tribenuron-methyl herbicide-resistant rapeseed (Brasscia napus) for hybrid seed production using chemically induced male sterility. Theor Appl Genet. 2015;128:107-18 pubmed publisher
    ..An in vitro enzyme activity assay for acetohydroxyacid synthase (AHAS) suggested that the herbicide resistance is caused by a gain-of-function mutation in a copy of AHAS genes...
  8. Hungria M, Nakatani A, Souza R, Sei F, de Oliveira Chueire L, Arias C. Impact of the ahas transgene for herbicides resistance on biological nitrogen fixation and yield of soybean. Transgenic Res. 2015;24:155-65 pubmed publisher
    ..Cultivance CV127 transgenic soybean is a cultivar containing the ahas gene, which confers resistance to herbicides of the imidazolinone group...
  9. Harrington J, de Albuquerque Rocha N, Patel K, Verma S, McGuire D. Should Metformin Remain First-Line Medical Therapy for Patients with Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease? An Alternative Approach. Curr Diab Rep. 2018;18:64 pubmed publisher
    ..This article will review the evidence for CV effects of antihyperglycemic agents (AHAs), and propose an evidence-based treatment algorithm for patients with T2DM and ASCVD.
  10. Guo Y, Han M, Xu J, Zhang W. Analysis of acetohydroxyacid synthase variants from branched-chain amino acids-producing strains and their effects on the synthesis of branched-chain amino acids in Corynebacterium glutamicum. Protein Expr Purif. 2015;109:106-12 pubmed publisher
    Acetohydroxy acid synthase (AHAS) controls carbon flux through the branch point and determines the relative rates of the synthesis of isoleucine, valine and leucine, respectively. However, it is strongly regulated by its end products...
  11. Preston C, Malone J. Inheritance of resistance to 2,4-D and chlorsulfuron in a multiple-resistant population of Sisymbrium orientale. Pest Manag Sci. 2015;71:1523-8 pubmed publisher
    ..from South Australia has multiple resistance to auxinic herbicides and inhibitors of acetohydroxyacid synthase (AHAS). Inheritance of resistance to 2,4-D and chlorsulfuron was studied in this population...
  12. Qu R, Yang J, Liu Y, Chen Q, Hao G, Niu C, et al. Computational design of novel inhibitors to overcome weed resistance associated with acetohydroxyacid synthase (AHAS) P197L mutant. Pest Manag Sci. 2017;73:1373-1381 pubmed publisher
    Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) is the first common enzyme in the biosynthetic pathway leading to the branched-chain amino acids in plants and a wide range of microorganisms...
  13. Li H, Liu N, Wang W, Wang J, Gao W. Cloning and characterization of GST fusion tag stabilized large subunit of Escherichia coli acetohydroxyacid synthase I. J Biosci Bioeng. 2016;121:21-26 pubmed publisher
    There are three acetohydroxyacid synthase (AHAS, EC 4.1.3.18) isozymes (I, II, and III) in the enterobacteria Escherichia coli among which AHAS I is the most active...
  14. Lonhienne T, Garcia M, Pierens G, Mobli M, Nouwens A, Guddat L. Structural insights into the mechanism of inhibition of AHAS by herbicides. Proc Natl Acad Sci U S A. 2018;115:E1945-E1954 pubmed publisher
    Acetohydroxyacid synthase (AHAS), the first enzyme in the branched amino acid biosynthesis pathway, is present only in plants and microorganisms, and it is the target of >50 commercial herbicides...
  15. Guo W, Yuan G, Liu W, Bi Y, Du L, Zhang C, et al. Multiple resistance to ACCase and AHAS-inhibiting herbicides in shortawn foxtail (Alopecurus aequalis Sobol.) from China. Pestic Biochem Physiol. 2015;124:66-72 pubmed publisher
    ..Molecular analyses revealed that Asp2078Gly mutation of ACCase and Trp574Leu mutation of AHAS were present in plants of the AHSX-1 population...
  16. Kitamura T, Seki N, Kihara A. Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2017;114:E2616-E2623 pubmed publisher
    ..We also identify HACL2 (2-hydroxyacyl-CoA lyase 2) [previous name, ILVBL; ilvB (bacterial acetolactate synthase)-like] as the major 2-OH acyl-CoA lyase involved in the cleavage (C1 ..
  17. Buysman E, Anderson A, Bacchus S, Ingham M. Retrospective Study on the Impact of Adherence in Achieving Glycemic Goals in Type 2 Diabetes Mellitus Patients Receiving Canagliflozin. Adv Ther. 2017;34:937-953 pubmed publisher
    Adherence is poor among patients taking antihyperglycemic agents (AHAs) for type 2 diabetes mellitus (T2DM). Inadequate adherence has been linked to decreased glycemic control and increased healthcare costs and hospitalizations...
  18. Chen K, Li X, Zhang S, Shi B. Synthesis of chiral α-hydroxy acids via palladium-catalyzed C(sp(3))-H alkylation of lactic acid. Chem Commun (Camb). 2016;52:1915-8 pubmed publisher
    ..the reaction conditions, providing a practical and straightforward alternative to access chiral α-hydroxy acids (AHAs). The new reactions have been applied for the synthesis of isotope-labeled AHAs and a sugar-containing complex AHA. ..
  19. Shoba D, Raveendran M, Manonmani S, Utharasu S, Dhivyapriya D, Subhasini G, et al. Development and Genetic Characterization of A Novel Herbicide (Imazethapyr) Tolerant Mutant in Rice (Oryza sativa L.). Rice (N Y). 2017;10:10 pubmed publisher
    ..an Acetolactate Synthase (ALS) on chromosome 6 and two Acetohydroxy Acid Synthase (AHAS) genes, one on chromosomes 2 and another on chromosome 4. RM 6844 on chromosome 2 located 0...
  20. Takpho N, Watanabe D, Takagi H. High-level production of valine by expression of the feedback inhibition-insensitive acetohydroxyacid synthase in Saccharomyces cerevisiae. Metab Eng. 2018;46:60-67 pubmed publisher
    ..valine biosynthesis is regulated by valine itself via the feedback inhibition of acetohydroxyacid synthase (AHAS), which consists of two subunits, the catalytic subunit Ilv2 and the regulatory subunit Ilv6...
  21. Wei W, Cheng D, Liu J, Li Y, Ma Y, Li Y, et al. Design, synthesis and SAR study of novel sulfonylureas containing an alkenyl moiety. Org Biomol Chem. 2016;14:8356-66 pubmed publisher
    ..In order to study the fungicidal mechanism, 9z was successfully docked into yeast AHAS using a flexible molecular docking method and the resulting binding pattern was similar to that of chlorimuron-..
  22. Haruta M, Gray W, Sussman M. Regulation of the plasma membrane proton pump (H(+)-ATPase) by phosphorylation. Curr Opin Plant Biol. 2015;28:68-75 pubmed publisher
    ..the family of P-type ATPases specialized for proton transport (commonly called PM H(+)-ATPases or, in Arabidopsis, AHAs for Arabidopsis H(+)-ATPases)...
  23. Parveen R, Agarwal N, Kaushal N, Mali G, Raisuddin S. Efficacy and safety of canagliflozin in type 2 diabetes mellitus: systematic review of randomized controlled trials. Expert Opin Pharmacother. 2016;17:105-15 pubmed publisher
    Currently available antihyperglycemic agents (AHAs), despite being effective, do not provide adequate glycemic control in some cases and are associated with side effects...
  24. Song D, Wu G, Vrinten P, Qiu X. Development of imidazolinone herbicide tolerant borage (Borago officinalis L.). Plant Sci. 2017;262:74-80 pubmed publisher
    ..Sequence analysis of two acetohydroxyacid synthase (AHAS) genes, AHAS1 and AHAS2, from the mutant (tolerant) and wild type (susceptible) borage plants showed that single ..
  25. Montejano L, Vo L, McMorrow D. Transitions of Care for People with Type 2 Diabetes: Utilization of Antihyperglycemic Agents Pre- and Post-Hospitalization. Diabetes Ther. 2016;7:91-103 pubmed publisher
    ..Twenty-one percent had no T2DM diagnosis or claims for AHAs in the 90-day pre-hospitalization period suggesting they may have been newly diagnosed at the time of admission...
  26. Aslan A, Birmingham W, Karagüler N, Turner N, Binay B. Semi-Rational Design of Geobacillus stearothermophilus L-Lactate Dehydrogenase to Access Various Chiral α-Hydroxy Acids. Appl Biochem Biotechnol. 2016;179:474-84 pubmed publisher
    Chiral α-hydroxy acids (AHAs) are rapidly becoming important synthetic building blocks, in particular for the production of pharmaceuticals and other fine chemicals...
  27. Lonhienne T, Nouwens A, Williams C, Fraser J, Lee Y, West N, et al. Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angew Chem Int Ed Engl. 2016;55:4247-51 pubmed publisher
    Acetohydroxyacid synthase (AHAS) inhibitors are highly successful commercial herbicides. New kinetic data show that the binding of these compounds leads to reversible accumulative inhibition of AHAS...
  28. Barrell P, Latimer J, Baldwin S, Thompson M, Jacobs J, Conner A. Somatic cell selection for chlorsulfuron-resistant mutants in potato: identification of point mutations in the acetohydroxyacid synthase gene. BMC Biotechnol. 2017;17:49 pubmed publisher
    ..and two variants were confirmed to have different independent point mutations in the acetohydroxyacid synthase (AHAS) gene...
  29. Buysman E, Chow W, Henk H, Rupnow M. Characteristics and outcomes of patients with type 2 diabetes mellitus treated with canagliflozin: a real-world analysis. BMC Endocr Disord. 2015;15:67 pubmed publisher
    ..canagliflozin claim, 21 % used canagliflozin concomitantly with three or more other antihyperglycemic agents (AHAs), 29 % with two other AHAs, 30 % with one other AHA, and 20 % without other AHAs...
  30. Heaton P, Desai V, Kelton C, Rajpathak S. Sulfonylurea use and the risk of hospital readmission in patients with type 2 diabetes. BMC Endocr Disord. 2016;16:4 pubmed publisher
    ..2 diabetes treated with sulfonylureas (SUs) compared to those treated with other oral antihyperglycemic agents (AHAs)...
  31. Amos T, Montejano L, Juneau P, Bolge S. Healthcare costs of urinary tract infections and genital mycotic infections among patients with type 2 diabetes mellitus initiated on canagliflozin: a retrospective cohort study. J Med Econ. 2017;20:303-313 pubmed publisher
    ..initiation were propensity score matched to controls with T2DM initiated on other anti-hyperglycemic agents (AHAs). UTI and GMI healthcare costs were evaluated 90-days post-index and reported as cohort means...
  32. Pandolfo C, Presotto A, Carbonell F, Ureta S, Poverene M, Cantamutto M. Transgenic glyphosate-resistant oilseed rape (Brassica napus) as an invasive weed in Argentina: detection, characterization, and control alternatives. Environ Sci Pollut Res Int. 2016;23:24081-24091 pubmed
    ..b>AHAS-inhibiting herbicides (imazethapyr, chlorimuron and diclosulam), glufosinate, 2,4-D, fluroxypyr and saflufenacil ..
  33. Qiu R, Balis D, Xie J, Davies M, Desai M, Meininger G. Longer-term safety and tolerability of canagliflozin in patients with type 2 diabetes: a pooled analysis. Curr Med Res Opin. 2017;33:553-562 pubmed publisher
    ..Canagliflozin 100 and 300?mg as monotherapy or in combination with various background antihyperglycemic agents (AHAs) were compared with pooled non-canagliflozin treatments (i.e. placebo, sitagliptin, glimepiride)...
  34. Golombieski J, Sutili F, Salbego J, Seben D, Gressler L, da Cunha J, et al. Imazapyr+imazapic herbicide determines acute toxicity in silver catfish Rhamdia quelen. Ecotoxicol Environ Saf. 2016;128:91-9 pubmed publisher
    ..The present findings demonstrate that, despite IMY+IMI targets the animal-absent AHAS enzyme, such formulation displayed an acute toxic effect upon R...
  35. Kim S, Kang I, Shin M, Jeong K, Baek J, Koh J, et al. Impact of chemical peeling combined with negative pressure on human skin. Int J Cosmet Sci. 2016;38:440-3 pubmed publisher
    In vivo changes in skin barrier function after chemical peeling with alpha hydroxyacids (AHAs) have been previously reported...
  36. Liu Y, Qu R, Chen Q, Yang J, Cong Wei N, Zhen X, et al. Triazolopyrimidines as a New Herbicidal Lead for Combating Weed Resistance Associated with Acetohydroxyacid Synthase Mutation. J Agric Food Chem. 2016;64:4845-57 pubmed publisher
    Acetohydroxyacid synthase (AHAS; also known as acetolactate synthase; EC 2.2.1.6, formerly EC 4.1.3...
  37. Araldi R, Dos Santos M, Barbon F, Manjerona B, Meirelles B, de Oliva Neto P, et al. Analysis of antioxidant, cytotoxic and mutagenic potential of Agave sisalana Perrine extracts using Vero cells, human lymphocytes and mice polychromatic erythrocytes. Biomed Pharmacother. 2018;98:873-885 pubmed publisher
    ..study analyzed the antioxidant, cytotoxic and mutagenic potential of three extracts derived from acid hydrolysis (AHAS), dried precipitate (DPAS) and hexanic of A. sisalana (HAS)...
  38. Qiu R, Balis D, Capuano G, Xie J, Meininger G. Canagliflozin: Efficacy and Safety in Combination with Metformin Alone or with Other Antihyperglycemic Agents in Type 2 Diabetes. Diabetes Ther. 2016;7:659-678 pubmed
    ..were on background therapy that consisted of metformin alone or in combination with other antihyperglycemic agents (AHAs; e.g., pioglitazone, sulfonylurea, and insulin)...
  39. Davidson J, Sloan L. Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview. Adv Ther. 2017;34:41-59 pubmed publisher
    ..goals with metformin monotherapy and require subsequent combination therapy with other antihyperglycemic agents (AHAs)...
  40. Garcia M, Wang J, Lonhienne T, Guddat L. Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides. FEBS J. 2017;284:2037-2051 pubmed publisher
    Acetohydroxyacid synthase (AHAS, EC 2.2.1.6) is the first enzyme in the branched-chain amino acid biosynthesis pathway. Five of the most widely used commercial herbicides (i.e...
  41. Garcia M, Nouwens A, Lonhienne T, Guddat L. Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Proc Natl Acad Sci U S A. 2017;114:E1091-E1100 pubmed publisher
    Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which is the first enzyme in the branched-chain amino acid biosynthesis pathway...
  42. Xing A, Last R. A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network. Plant Cell. 2017;29:1480-1499 pubmed publisher
    ..In this model, OMR1 exerts primary control on Ile accumulation and functions independently of AHAS and IPMS AHAS and IPMS regulate Val and Leu homeostasis, where AHAS affects total Val+Leu and IPMS controls ..
  43. Falkenburg W, van Schaardenburg D, Ooijevaar de Heer P, Tsang A Sjoe M, Bultink I, Voskuyl A, et al. Anti-Hinge Antibodies Recognize IgG Subclass- and Protease-Restricted Neoepitopes. J Immunol. 2017;198:82-93 pubmed
    Anti-hinge Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG...
  44. Mangano S, Martínez Pacheco J, Marino Buslje C, Estevez J. How Does pH Fit in with Oscillating Polar Growth?. Trends Plant Sci. 2018;23:479-489 pubmed publisher
    ..considers that auxin triggers apoplastic acidification by activating plasma membrane P-type H+-ATPases (AHAs) along with cell wall relaxation over long periods, the apoplastic pH (apopH) regulatory mechanisms are ..
  45. Jung I, Ha N, Lee S, Ryoo S, Yoon M. Development of potent chemical antituberculosis agents targeting Mycobacterium tuberculosis acetohydroxyacid synthase. Int J Antimicrob Agents. 2016;48:247-58 pubmed publisher
    Mycobacterium tuberculosis acetohydroxyacid synthase (MTB-AHAS) has been suggested as a crucial target for antibacterial agents. High-throughput screening of a chemical library was performed to identify potent new inhibitors of MTB-AHAS...
  46. Petrić I, Karpouzas D, Bru D, Udiković Kolić N, Kandeler E, Djuric S, et al. Nicosulfuron application in agricultural soils drives the selection towards NS-tolerant microorganisms harboring various levels of sensitivity to nicosulfuron. Environ Sci Pollut Res Int. 2016;23:4320-33 pubmed publisher
    The action mode of sulfonylurea herbicides is the inhibition of the acetohydroxyacid synthase (AHAS) required for the biosynthesis of amino acids valine and isoleucine in plants...
  47. Ladwig F, Dahlke R, Stührwohldt N, Hartmann J, Harter K, Sauter M. Phytosulfokine Regulates Growth in Arabidopsis through a Response Module at the Plasma Membrane That Includes CYCLIC NUCLEOTIDE-GATED CHANNEL17, H+-ATPase, and BAK1. Plant Cell. 2015;27:1718-29 pubmed publisher
    ..We hypothesize that CNGC17 and AHAs form a functional cation-translocating unit that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes.
  48. Mao B, Gao M, Chen C, Li Z, Zhang H, Zhang Q. Design, synthesis and biological evaluation of novel N-nitrophenyl derivatives based on the structure of acetohydroxyacid synthase. Pestic Biochem Physiol. 2018;145:100-107 pubmed publisher
    Acetohydroxyacid synthase (AHAS, EC: 2.2.1.6) is a target for the development of novel herbicides. Two series of N-nitrophenyl derivatives, type-A and type-B, were designed and synthesized based on the active site of the AHAS structure...
  49. Jung I, Cho J, Koo B, Yoon M. Functional evaluation of residues in the herbicide-binding site of Mycobacterium tuberculosis acetohydroxyacid synthase by site-directed mutagenesis. Enzyme Microb Technol. 2015;78:18-26 pubmed publisher
    Mycobacterium tuberculosis acetohydroxyacid synthase (M. tuberculosis AHAS) has been proposed to bean essential target for novel herbicide- and chemical-based antibacterial agents...
  50. Ma Y, Beckstead J, Lo S, Yang C. Auditory Hallucinatory Beliefs in Patients With Schizophrenia: Association of Auditory Hallucinations With Social Interactions, Characteristics and Emotional Behaviors Over 3 Months. Arch Psychiatr Nurs. 2016;30:363-9 pubmed publisher
    ..Participants (n=189) were evaluated using the Auditory Hallucinations Assessment Scale (AHAS) and the Assessment of Communication and Interaction Skills (ACIS)...
  51. Chow W, Buysman E, Rupnow M, Aguilar R, Henk H. Canagliflozin treatment of Hispanic and non-Hispanic patients with type 2 diabetes in a US managed care setting. Curr Med Res Opin. 2016;32:13-22 pubmed publisher
    ..Few studies of antihyperglycemic agents (AHAs) have compared H/L with non-H/L patients...
  52. Lonhienne T, Garcia M, Guddat L. The Role of a FAD Cofactor in the Regulation of Acetohydroxyacid Synthase by Redox Signaling Molecules. J Biol Chem. 2017;292:5101-5109 pubmed publisher
    Acetohydroxyacid synthase (AHAS) catalyzes the first step of branched-chain amino acid (BCAA) biosynthesis, a pathway essential to the lifecycle of plants and microorganisms...
  53. Weir M. The kidney and type 2 diabetes mellitus: therapeutic implications of SGLT2 inhibitors. Postgrad Med. 2016;128:290-8 pubmed publisher
    ..in recent years with the arrival of sodium-glucose co-transporter 2 (SGLT2) inhibitors - antihyperglycemic agents (AHAs) that specifically target the kidneys...
  54. Liu Y, Li Y, Wang X. Molecular evolution of acetohydroxyacid synthase in bacteria. Microbiologyopen. 2017;6: pubmed publisher
    Acetohydroxyacid synthase (AHAS) is the key enzyme in the biosynthetic pathways of branched chain amino acids in bacteria...
  55. Piao Z, Wang W, Wei Y, Zonta F, Wan C, Bai J, et al. Characterization of an acetohydroxy acid synthase mutant conferring tolerance to imidazolinone herbicides in rice (Oryza sativa). Planta. 2018;247:693-703 pubmed publisher
    ..Acetohydroxy acid synthase (AHAS) mutations have been found to confer herbicide tolerance to rice...
  56. Zhang L, Guo W, Li Q, Wu C, Zhao N, Liu W, et al. Tribenuron-methyl resistance and mutation diversity of the AHAS gene in shepherd's purse (Capsella bursa-pastoris (L.) Medik.) in Henan Province, China. Pestic Biochem Physiol. 2017;143:239-245 pubmed publisher
    ..areas in Henan Province and used to evaluate tribenuron-methyl resistance and acetohydroxyacid synthase (AHAS) gene-mutation diversity...
  57. Qu R, Yang J, Ponnam D, Kang W, Liu Y, Chen Q, et al. Discovery of New 2-[(4,6-Dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(substituted phenoxy)benzoic Acids as Flexible Inhibitors of Arabidopsis thaliana Acetohydroxyacid Synthase and Its P197L Mutant. J Agric Food Chem. 2017;: pubmed publisher
    In the search for new anti-resistance acetohydroxyacid synthase (AHAS, EC 2.2.1...
  58. Huang T, Mathieu M, Lee S, Wang X, Kee Y, Bevers J, et al. Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells. J Biol Chem. 2018;293:906-919 pubmed publisher
    Anti-hinge antibodies (AHAs) are an autoantibody subclass that, following proteolytic cleavage, recognize cryptic epitopes exposed in the hinge regions of immunoglobulins (Igs) and do not bind to the intact Ig counterpart...
  59. Udell J, Yuan Z, Rush T, Sicignano N, Galitz M, Rosenthal N. Cardiovascular Outcomes and Risks After Initiation of a Sodium Glucose Cotransporter 2 Inhibitor: Results From the EASEL Population-Based Cohort Study (Evidence for Cardiovascular Outcomes With Sodium Glucose Cotransporter 2 Inhibitors in the Real Wo. Circulation. 2018;137:1450-1459 pubmed publisher
    ..It remains unclear whether the below-knee lower extremity amputation risk extends across the class of medication, because the study was not powered to make comparisons among individual treatments. ..
  60. Newman E, Terunuma M, Wang T, Hewage N, Bicakci M, Moss S, et al. A Role for Prefrontal Cortical NMDA Receptors in Murine Alcohol-Heightened Aggression. Neuropsychopharmacology. 2017;: pubmed publisher
    ..Here, male mice were characterized as alcohol-heightened (AHAs) or alcohol non-heightened aggressors (ANAs) during resident-intruder confrontations after self-administering 1...
  61. Chang H, Park J, Lee H, Lyu J, Son J, Choi I, et al. Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma. BMC Pulm Med. 2017;17:210 pubmed publisher
    We previously reported that the ILVBL gene on chromosome 19p13...
  62. Balabanova D, Remans T, Vassilev A, Cuypers A, Vangronsveld J. Possible involvement of glutathione S-transferases in imazamox detoxification in an imidazolinone-resistant sunflower hybrid. J Plant Physiol. 2018;221:62-65 pubmed publisher
    ..The target site resistance consists of a mutation in Ahasl1 gene, encoding the synthesis of the AHAS enzyme...
  63. Joutel A, Ducros A, Alamowitch S, Cruaud C, Domenga V, Marechal E, et al. A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region. Genomics. 1996;38:192-8 pubmed
  64. Wei W, Zhou S, Cheng D, Li Y, Liu J, Xie Y, et al. Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors. Bioorg Med Chem Lett. 2017;27:3365-3369 pubmed publisher
    ..their apparent inhibition constant (Kiapp) of Arabidopsis thaliana acetohydroxyacid synthase (AHAS) were determined and the results confirmed that these compounds were all potent AHAS inhibitors...
  65. Dong X, Zhao Y, Zhao J, Wang X. Characterization of aspartate kinase and homoserine dehydrogenase from Corynebacterium glutamicum IWJ001 and systematic investigation of L-isoleucine biosynthesis. J Ind Microbiol Biotechnol. 2016;43:873-85 pubmed publisher
    ..a threonine dehydratase mutant TD(F383V) (encoded by ilvA1) and an acetohydroxy acid synthase mutant AHAS(P176S, D426E, L575W) (encoded by ilvBN1) in Corynebacterium glutamicum IWJ001, one of the best L-isoleucine ..
  66. Xie J, Zhao L, Liu K, Guo F, Gao L, Liu W. Activity, toxicity, molecular docking, and environmental effects of three imidazolinone herbicides enantiomers. Sci Total Environ. 2018;622-623:594-602 pubmed publisher
    ..modeling provided the rational structural basis for the enantioselectivity of the acetohydroxyacid synthase (AHAS) activity of the IMIs...
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    ..It was also shown that they had multiple resistance to AHAS-inhibiting herbicides. The transgenic origin of the glyphosate resistance in B...
  68. Zhang Y, Xu Y, Wang S, Li X, Zheng M. Resistance mutations of Pro197, Asp376 and Trp574 in the acetohydroxyacid synthase (AHAS) affect pigments, growths, and competitiveness of Descurainia sophia L. Sci Rep. 2017;7:16380 pubmed publisher
    ..Amino acid substitutions at site of Pro197, Asp376 and Trp574 in acetohydroxyacid synthase (AHAS) were mainly responsible for D. sophia resistance to tribenuron-methyl. In this study, D...
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    ..reporting the presence of autoantibodies reacting against cells of the pituitary (APAs) and/or hypothalamus (AHAs). Both APAs and AHAs have been revealed through immunofluorescence using different kinds of substrates...
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    ..type 2 diabetes who are newly treated with SGLT2 inhibitors (SGLT2i) versus non-SGLT2i antihyperglycemic agents (AHAs) in actual clinical practice. A new-user cohort study design using a large insurance claims database in the US...