Gene Symbol: ILKAP
Description: ILK associated serine/threonine phosphatase
Alias: ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, integrin-linked kinase-associated serine/threonine phosphatase 2C, integrin-linked kinase associated phosphatase, protein phosphatase 2c, delta isozyme, protein phosphatase, Mg2+/Mn2+ dependent 1O
Species: human
Products:     ILKAP

Top Publications

  1. Kumar A, Naruszewicz I, Wang P, Leung Hagesteijn C, Hannigan G. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Oncogene. 2004;23:3454-61 pubmed
    b>ILKAP is a protein phosphatase 2C that selectively associates with integrin linked kinase, ILK, to modulate cell adhesion and growth factor signaling...
  2. Zhou W, Cao H, Yang X, Cong K, Wang W, Chen T, et al. Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling. J Biol Chem. 2013;288:6259-71 pubmed publisher
    Integrin-linked kinase-associated phosphatase (ILKAP) is a serine/threonine (S/T) phosphatase that belongs to the protein phosphatase 2C (PP2C) family...
  3. Lorenzato A, Torchiaro E, Olivero M, Di Renzo M. The integrin-linked kinase-associated phosphatase (ILKAP) is a regulatory hub of ovarian cancer cell susceptibility to platinum drugs. Eur J Cancer. 2016;60:59-68 pubmed publisher
    ..also resulted in the increased expression of the integrin-linked kinase (ILK)-associated phosphatase (ILKAP) that dephosphorylated the p90RSK. Conversely, CDDP down-modulated ILKAP expression...
  4. Leung Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan G. Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. EMBO J. 2001;20:2160-70 pubmed
    b>ILKAP, a protein serine/threonine (S/T) phosphatase of the PP2C family, was isolated in a yeast two-hybrid screen baited with integrin-linked kinase, ILK1...
  5. Zhou W, Cui S, Han S, Cheng B, Zheng Y, Zhang Y. Palladin is a novel binding partner of ILKAP in eukaryotic cells. Biochem Biophys Res Commun. 2011;411:768-73 pubmed publisher
    Palladin was a novel binding partner of ILKAP in eukaryotic cells...
  6. Arroyo Berdugo Y, Alonso S, Ribas G, Ibarrola Villava M, Peña Chilet M, Martinez Cadenas C, et al. Involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma. PLoS ONE. 2014;9:e95522 pubmed publisher
    ..Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free ..
  7. Shao G, Zheng Q, Xu X, Zhao J, Liu P. Endometrial ILKAP expression among patients with endometriosis and its association with clinical characteristics. Int J Gynaecol Obstet. 2015;130:23-6 pubmed publisher
    To investigate expression of ILKAP among women with endometriosis and its association with clinical characteristics...
  8. Tong Y, Quirion R, Shen S. Cloning and characterization of a novel mammalian PP2C isozyme. J Biol Chem. 1998;273:35282-90 pubmed
    ..These results suggest that PP2Cdelta plays a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. ..
  9. Nakrieko K, Vespa A, Mason D, Irvine T, D Souza S, Dagnino L. Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1. Cell Cycle. 2008;7:2157-66 pubmed
    ..into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP. Nuclear localization of ILK in epidermal keratinocytes is associated with increased DNA synthesis, which is ..

More Information


  1. Hausmann C, Temme A, Cordes N, Eke I. ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation. Oncotarget. 2015;6:34592-605 pubmed publisher
    ..interesting new cysteine-histidine-rich 1 (PINCH1), integrin-linked kinase (ILK) and ILK associated phosphatase (ILKAP) modulates GBM cell radioresistance...