IL7R

Summary

Gene Symbol: IL7R
Description: interleukin 7 receptor
Alias: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, interleukin-7 receptor subunit alpha, CD127 antigen, IL-7 receptor subunit alpha, IL-7R subunit alpha, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6
Species: human
Products:     IL7R

Top Publications

  1. Rose T, Lambotte O, Pallier C, Delfraissy J, Colle J. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol. 2009;182:7389-97 pubmed publisher
    ..0014) 2-fold decrease in plasma sIL-7Ralpha levels compared with those in control healthy individuals. Plasma IL-7 and sIL-7Ralpha levels did not show any obvious relationship. ..
  2. Henriques C, Rino J, Nibbs R, Graham G, Barata J. IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells. Blood. 2010;115:3269-77 pubmed publisher
    ..It is well established that IL-7 promotes the transcriptional down-regulation of IL7RA, leading to decreased IL-7Ralpha surface expression...
  3. Hoe E, McKay F, Schibeci S, Gandhi K, Heard R, Stewart G, et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol. 2010;184:2512-7 pubmed publisher
    ..Because signaling through IL-7Ralpha controls T cell regulation, this haplotype difference is likely to affect the immunophenotype and disease pathogenesis. ..
  4. De Jager P, Chibnik L, Cui J, Reischl J, Lehr S, Simon K, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol. 2009;8:1111-9 pubmed publisher
    ..Future iterations of the wGRS might therefore make a contribution to algorithms that can predict a diagnosis of MS in a clinical or research setting. ..
  5. McKay F, Swain L, Schibeci S, Rubio J, Kilpatrick T, Heard R, et al. Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun. 2008;9:1-6 pubmed
    IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple ..
  6. Seddiki N, Santner Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med. 2006;203:1693-700 pubmed
    ..Here, we show that expression of CD127, the alpha chain of the interleukin-7 receptor, allows an unambiguous flow cytometry-based distinction to be made ..
  7. Johnson B, Wang J, Taylor E, Caillier S, Herbert J, Khan O, et al. Multiple sclerosis susceptibility alleles in African Americans. Genes Immun. 2010;11:343-50 pubmed publisher
    ..The results are consistent with shared disease genetic mechanisms among individuals of European and African ancestry. ..
  8. O Doherty C, Alloza I, Rooney M, Vandenbroeck K. IL7RA polymorphisms and chronic inflammatory arthropathies. Tissue Antigens. 2009;74:429-31 pubmed publisher
    ..C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes...
  9. Hartgring S, van Roon J, Wenting van Wijk M, Jacobs K, Jahangier Z, Willis C, et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum. 2009;60:2595-605 pubmed publisher
    ..The inhibition of IL-7R-mediated immune activation by soluble hIL-7Ralpha further indicates an important role of IL-7Ralpha in inflammatory responses in RA, suggesting IL-7Ralpha as a therapeutic target for immunotherapy in RA. ..

More Information

Publications76

  1. Paiardini M, Cervasi B, Albrecht H, Muthukumar A, Dunham R, Gordon S, et al. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. J Immunol. 2005;174:2900-9 pubmed
    ..In this study we show that in HIV-infected individuals the loss of IL-7R (CD127) expression defines the expansion of a subset of CD8(+) T cells, specific for HIV as well as other Ags, that show ..
  2. Shochat C, Tal N, Bandapalli O, Palmi C, Ganmore I, Te Kronnie G, et al. Gain-of-function mutations in interleukin-7 receptor-? (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med. 2011;208:901-8 pubmed publisher
    Interleukin-7 receptor ? (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency...
  3. Santiago J, Alizadeh B, Martinez A, Espino L, de la Calle H, Fernandez Arquero M, et al. Study of the association between the CAPSL-IL7R locus and type 1 diabetes. Diabetologia. 2008;51:1653-8 pubmed publisher
    ..in a large white population and corroborated in a genome-wide analysis, which also found an association with IL7R, which is located adjacent to CAPSL...
  4. Hoppenbrouwers I, Aulchenko Y, Janssens A, Ramagopalan S, Broer L, Kayser M, et al. Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis. J Hum Genet. 2009;54:676-80 pubmed publisher
    ..Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12)...
  5. . Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet. 2009;41:824-8 pubmed publisher
    ..6 x 10(-8); evi5-rpl5, p = 2.5 x 10(-6); il2ra, p = 7.4 x 10(-6); clec16a, p = 1.1 x 10(-4); il7r, p = 1.3 x 10(-3); tyk2, p = 3...
  6. McElroy C, Dohm J, Walsh S. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure. 2009;17:54-65 pubmed publisher
    ..The IL-7/IL-7Ralpha structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases. ..
  7. Gregory S, Schmidt S, Seth P, Oksenberg J, Hart J, Prokop A, et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet. 2007;39:1083-91 pubmed
    ..We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for multiple sclerosis in four independent family-based or case-..
  8. Faller E, Kakal J, Kumar R, MacPherson P. IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells. Int Immunol. 2009;21:203-16 pubmed publisher
    ..We have previously shown decreased expression of the IL-7 receptor alpha-chain (CD127) on CD8 T cells from HIV-infected patients with active viral replication...
  9. De Jager P, Jia X, Wang J, de Bakker P, Ottoboni L, Aggarwal N, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009;41:776-82 pubmed publisher
  10. Faller E, McVey M, Kakal J, MacPherson P. Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein. J Acquir Immune Defic Syndr. 2006;43:257-69 pubmed
    We have previously shown decreased expression of the interleukin (IL)-7 receptor alpha-chain (CD127) on CD8 T-cells in HIV-infected patients and an apparent recovery of this receptor in those receiving antiretroviral therapy with ..
  11. Todd J, Walker N, Cooper J, Smyth D, Downes K, Plagnol V, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet. 2007;39:857-64 pubmed
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten. ..
  12. Hartigan O Connor D, Poon C, Sinclair E, McCune J. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods. 2007;319:41-52 pubmed publisher
    ..T-regs, but consistent and specific discrimination of functional T-regs was only made possible by focus on CD127, the alpha chain of the IL-7 receptor...
  13. Crawley A, Faucher S, Angel J. Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol. 2010;184:4679-87 pubmed publisher
    Soluble CD127 (sCD127) appears to play an important role in the immunopathogenesis of several chronic infections, multiple sclerosis, and various cancers...
  14. Liu W, Putnam A, Xu Yu Z, Szot G, Lee M, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006;203:1701-11 pubmed
    ..We found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4(+) T cells in peripheral blood...
  15. Swainson L, Verhoeyen E, Cosset F, Taylor N. IL-7R alpha gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes. J Immunol. 2006;176:6702-8 pubmed
    ..Thus, IL-7 therapy should be designed to allow optimal responsiveness of naive and memory T cell subsets. ..
  16. Shamim Z, Ryder L, Heilmann C, Madsen H, Lauersen H, Andersen P, et al. Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantation. Bone Marrow Transplant. 2006;37:485-91 pubmed
    ..These findings suggest that the IL-7Ralpha polymorphisms may be of importance for treatment-related mortality after SCT. ..
  17. Kim H, Hong M, Dan J, Kang I. Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood. 2006;107:2855-62 pubmed
  18. Rajasuriar R, Booth D, Solomon A, Chua K, Spelman T, Gouillou M, et al. Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor ? and microbial translocation. J Infect Dis. 2010;202:1254-64 pubmed publisher
    ..001). Both the extent of immune depletion prior to ART and IL-7R? haplotype 2 are important determinants of time to CD4(+) T cell recovery to counts of >500 cells/?L. ..
  19. Fuller M, Hildeman D, Sabbaj S, Gaddis D, Tebo A, Shang L, et al. Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol. 2005;174:5926-30 pubmed
    ..report we have inspected whether difficulties in controlling viral infections negatively impacts the generation of CD127(high) memory T cells...
  20. Zhang Z, Duvefelt K, Svensson F, Masterman T, Jonasdottir G, Salter H, et al. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun. 2005;6:145-52 pubmed
    ..05) associated SNPs--conferred susceptibility to MS: LAG3 on chromosome 12p13, and IL7R on 5p13. LAG3 inhibits activated T cells, while IL7R is necessary for the maturation of T and B cells...
  21. Roifman C, Zhang J, Chitayat D, Sharfe N. A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood. 2000;96:2803-7 pubmed
    ..This underscores the critical role of IL-7R alpha chain in the differentiation of T cells. (Blood. 2000;96:2803-2807) ..
  22. Puel A, Ziegler S, Buckley R, Leonard W. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet. 1998;20:394-7 pubmed
    ..Some SCID patients lack T cells but retain NK cells. Given diminished T-cell development in Il7- or Il7r-deficient mice and that Il/7r-deficient mice have NK cells, we hypothesized that T(-)B(+)NK(+) SCID might result ..
  23. Ghazawi F, Faller E, Sugden S, Kakal J, MacPherson P. IL-7 downregulates IL-7R? expression in human CD8 T cells by two independent mechanisms. Immunol Cell Biol. 2013;91:149-58 pubmed publisher
    ..It is therefore no surprise that expression of the IL-7 receptor alpha-chain (CD127) is tightly regulated...
  24. Goodwin R, Friend D, Ziegler S, Jerzy R, Falk B, Gimpel S, et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990;60:941-51 pubmed
    ..Analysis of the sequence of the IL-7 receptor revealed significant homology in the extracellular domain to several recently cloned cytokine receptors, demonstrating that the IL-7 receptor is a member of a new receptor superfamily. ..
  25. Faller E, Sugden S, McVey M, Kakal J, MacPherson P. Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation. J Immunol. 2010;185:2854-66 pubmed publisher
    ..We have previously shown decreased expression of the IL-7R alpha-chain (CD127) on CD8 T cells in HIV(+) patients and that this downregulation is mediated at least in part by the HIV Tat ..
  26. Kreft K, Verbraak E, Wierenga Wolf A, van Meurs M, Oostra B, Laman J, et al. The IL-7R? pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis. J Immunol. 2012;188:1874-83 pubmed publisher
    ..This is of special interest in light of the established demyelinating and cytotoxic actions of granzyme A. ..
  27. Noguchi M, Nakamura Y, Russell S, Ziegler S, Tsang M, Cao X, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. 1993;262:1877-80 pubmed
    ..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma. ..
  28. Bazdar D, Kalinowska M, Sieg S. Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging. J Infect Dis. 2009;199:1019-28 pubmed publisher
    ..Although CD127 expression was diminished for T cells from HIV-infected persons, it was not directly related to IL-7 receptor ..
  29. Crawley A, Katz T, Parato K, Angel J. IL-2 receptor gamma chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T cell division and susceptibility to apoptosis. Int Immunol. 2009;21:29-42 pubmed publisher
    Expression of IL-7 receptor alpha (CD127) is associated with naive and memory (i.e. non-effector) CD8+ T cell phenotypes. Effector CD8+ T cells are predominantly CD127- and most die by apoptosis...
  30. Benito J, Lopez M, Lozano S, Gonzalez Lahoz J, Soriano V. Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy. J Infect Dis. 2008;198:1466-73 pubmed publisher
    ..Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127)...
  31. Dunham R, Cervasi B, Brenchley J, Albrecht H, Weintrob A, Sumpter B, et al. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. J Immunol. 2008;180:5582-92 pubmed
    ..into three subsets by the expression of receptors for two T cell-tropic cytokines, IL-2 (CD25) and IL-7 (CD127)...
  32. Read S, Higgins J, Metcalf J, Stevens R, Rupert A, Nason M, et al. Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy. J Acquir Immune Defic Syndr. 2006;42:537-44 pubmed
    ..IL-7 serum levels and CD127 (IL-7Ralpha) expression on T cells were evaluated in a cross-sectional study of 36 healthy volunteers, 151 HIV-..
  33. Vranjkovic A, Crawley A, Gee K, Kumar A, Angel J. IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Int Immunol. 2007;19:1329-39 pubmed
    IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis...
  34. Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallstrom E, Khademi M, et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet. 2007;39:1108-13 pubmed
    ..Here, we report compelling evidence that polymorphisms in IL7R, which encodes the interleukin 7 receptor alpha chain (IL7Ralpha), indeed contribute to the non-HLA genetic risk in multiple sclerosis, demonstrating a ..
  35. Pleiman C, Gimpel S, Park L, Harada H, Taniguchi T, Ziegler S. Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. Mol Cell Biol. 1991;11:3052-9 pubmed
    ..Comparison of the murine and human IL-7R exon/intron boundaries with those of other hematopoietin receptor superfamily members whose exon/intron boundaries are also known reveals a conserved evolutionary structure. ..
  36. Azarpira N, Dehghani M, Aghdaie M, Darai M. Interleukin-7 receptor-alpha gene polymorphisms in bone marrow transplant recipients. Mol Biol Rep. 2010;37:27-31 pubmed publisher
    ..Its effect is mediated via interleukin 7 receptor (IL7R)...
  37. Hafler D, Compston A, Sawcer S, Lander E, Daly M, De Jager P, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007;357:851-62 pubmed
    ..96x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)) and multiple SNPs in the HLA-DRA locus (P=8.94x10(-81))...
  38. García Peydró M, de Yebenes V, Toribio M. Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates. J Immunol. 2006;177:3711-20 pubmed
    ..These data provide insight into a mechanism of Notch-regulated amplification of the intrathymic pool of early human T cell progenitors. ..
  39. De Grove K, Provoost S, Verhamme F, Bracke K, Joos G, Maes T, et al. Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung. PLoS ONE. 2016;11:e0145961 pubmed publisher
    ..Within the CD45+ Lin- CD127+ pulmonary ILC population, we identified group 1 (ILC1), group 2 (ILC2) and group 3 (ILC3) innate lymphoid cells ..
  40. Codarri L, Vallotton L, Ciuffreda D, Venetz J, Garcia M, Hadaya K, et al. Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Ralphahigh cell population in solid organ transplant recipients. J Exp Med. 2007;204:1533-41 pubmed
    ..These results indicate that the CD4(+)CD25(+)IL-7Ralpha(+) cell population may represent a valuable, sensitive, and specific marker to monitor allospecific CD4 T cell responses both in blood and in tissues after organ transplantation. ..
  41. Badot V, Durez P, Van den Eynde B, Nzeusseu Toukap A, Houssiau F, Lauwerys B. Rheumatoid arthritis synovial fibroblasts produce a soluble form of the interleukin-7 receptor in response to pro-inflammatory cytokines. J Cell Mol Med. 2011;15:2335-42 pubmed publisher
    ..In conclusion, sIL-7R is induced by pro-inflammatory cytokines in RA FLS. sIL-7R could qualify as a new biomarker of response to therapy in RA. ..
  42. Vallotton L, Hadaya K, Venetz J, Buehler L, Ciuffreda D, Nseir G, et al. Monitoring of CD4+CD25highIL-7R?high activated T cells in kidney transplant recipients. Clin J Am Soc Nephrol. 2011;6:2025-33 pubmed publisher
    ..The measurement of Tact, in addition to Treg, may become a useful immune monitoring tool after kidney transplantation. ..
  43. Saeidi A, Chong Y, Yong Y, Tan H, Barathan M, Rajarajeswaran J, et al. Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8(+) T cells in HIV/TB co-infection. Cell Immunol. 2015;297:19-32 pubmed publisher
    ..were directly proportional to lack of co-stimulatory markers on CD8(+) T cells, besides diminished expression of CD127 (IL-7Rα) on CD57(+)CD4(+) T cells...
  44. Pawlowski P, Grubczak K, Kostecki J, Ilendo Poskrobko E, Moniuszko M, Pawlowska M, et al. Decreased Frequencies of Peripheral Blood CD4+CD25+CD127-Foxp3+ in Patients with Graves' Disease and Graves' Orbitopathy: Enhancing Effect of Insulin Growth Factor-1 on Treg Cells. Horm Metab Res. 2017;49:185-191 pubmed publisher
    ..We analyzed the expression of Treg cell markers (CD4, CD25, CD127-, Foxp3) on T cells and their ability to respond to IGF-1 stimulation...
  45. O Doherty C, Kantarci O, Vandenbroeck K. IL7RA polymorphisms and susceptibility to multiple sclerosis. N Engl J Med. 2008;358:753-4 pubmed publisher
  46. Tabares P, Berr S, Langenhorst D, Sawitzki B, ten Berge I, Tony H, et al. Short-term cytokine stimulation reveals regulatory T cells with down-regulated Foxp3 expression in human peripheral blood. Eur J Immunol. 2017;: pubmed publisher
    ..At the same time, the uncovered Treg cells up-regulate CD25 and down-regulate CD127, making them accessible to viable cell sorting...
  47. Khan T, Iqbal A, Rahman H, Cabral Marques O, Ishfaq M, Muhammad N. Novel RAG1 mutation and the occurrence of mycobacterial and Chromobacterium violaceum infections in a case of leaky SCID. Microb Pathog. 2017;109:114-119 pubmed publisher
    ..is a potentially fatal primary immunodeficiency (PID) that is caused by mutations in genes such as IL2RG, JAK3, IL7RA, RAG1, RAG2, and ADA...
  48. D Netto M, Ward H, Morrison K, Ramagopalan S, Dyment D, DeLuca G, et al. Risk alleles for multiple sclerosis in multiplex families. Neurology. 2009;72:1984-8 pubmed publisher
    ..The aggregate of the IL2RA, IL7R, EVI5, KIAA0350, and CD58 risk genotypes in affected individuals from multiplex families was found to be notably ..
  49. Scupoli M, Vinante F, Krampera M, Vincenzi C, Nadali G, Zampieri F, et al. Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7. Haematologica. 2003;88:1229-37 pubmed
    ..In addition, they show that interaction between IL-7 and its receptor has the major role in modulating T-ALL survival within the microenvironment generated by the T-ALL/TEC interaction. ..
  50. Larrubia J, Benito Martínez S, Miquel J, Calvino M, Sanz de Villalobos E, Gonzalez Praetorius A, et al. Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1(+)/CD127(-) HCV-specific CD8(+) cells targeting the virus in chronic hepatitis C virus infection. Cell Immunol. 2011;269:104-14 pubmed publisher
    PD-1 molecule promotes anergy and IL-7 receptor (CD127) induces an anti-apoptotic effect on T cells...
  51. Janot Sardet C, Assouline B, Cheynier R, Morre M, Beq S. A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment. J Immunol Methods. 2010;353:115-23 pubmed publisher
    ..cytokine for T cell hematopoiesis and peripheral homeostasis which by signaling through its receptor alpha chain (CD127) is essential for inducing T cell proliferation and survival...
  52. Moya R, Robertson H, Payne D, Narsale A, Koziol J, Davies J. A pilot study showing associations between frequency of CD4(+) memory cell subsets at diagnosis and duration of partial remission in type 1 diabetes. Clin Immunol. 2016;166-167:72-80 pubmed publisher
    ..of CD4(+) memory cells, activated Treg cells and CD25(+) cells that express a high density of the IL-7 receptor, CD127 (CD127(hi)) are strongly associated with length of partial remission...
  53. Chernykh E, Leplina O, Oleynik E, Tikhonova M, Tyrinova T, Starostina N, et al. Immunotherapy with interferon-α-induced dendritic cells for chronic HCV infection (the results of pilot clinical trial). Immunol Res. 2018;66:31-43 pubmed publisher
    ..Vaccination did not cause Th2 response and expansion of the CD4+CD25+CD127- regulatory T cells. Generated immune responses failed to provide virus elimination...
  54. Jager J, Schulze C, Rosner S, Martin R. IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis. Genes Immun. 2013;14:453-61 pubmed publisher
    Interleukin-7 receptor alpha (IL7RA) is among the top listed candidate genes influencing the risk to develop multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system...
  55. Dhali A, Javvaji P, Kolte A, Francis J, Roy S, Sejian V. Temporal expression of cumulus cell marker genes during in vitro maturation and oocyte developmental competence. J Assist Reprod Genet. 2017;34:1493-1500 pubmed publisher
    ..At the 0 h of IVM, a significant upregulation in the expression of PTGS2, STAR, SDC2, LHR, FGF2, BCL2, IL7RA, HSPA1A, and IFNT was observed in the CC of the poor (BCB-) as compared to the competent (BCB+) oocytes...
  56. Nafady Hego H, Li Y, Ohe H, Elgendy H, Zhao X, Sakaguchi S, et al. Utility of CD127 combined with FOXP3 for identification of operational tolerance after liver transplantation. Transpl Immunol. 2016;36:1-8 pubmed publisher
    Loss of cell surface expression of CD127 on CD4(+)CD25(++) regulatory T-cells (Tregs) may be a useful marker to efficiently isolate Tregs...
  57. Vitiello G, Losi Guembarovski R, Amarante M, Ceribelli J, Carmelo E, Watanabe M. Interleukin 7 receptor alpha Thr244Ile genetic polymorphism is associated with susceptibility and prognostic markers in breast cancer subgroups. Cytokine. 2018;103:121-126 pubmed publisher
    ..AC>T polymorphism (rs6897932; Thr244Ile) at exon 6 of IL-7 receptor alpha (IL-7Rα) gene (IL7RA) shifts the balance between the membrane-bound and soluble IL-7Rα splicing variants and was previously associated ..
  58. Judge C, Kostadinova L, Sherman K, Butt A, Falck Ytter Y, Funderburg N, et al. CD56bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections. J Leukoc Biol. 2017;102:171-184 pubmed publisher
    ..Here, we measured CD127 expression on CD56bright, CD56dimCD16+ (CD56dim), or CD56neg..
  59. Sathe P, Pang S, Delconte R, Elwood N, Huntington N. Identification of Novel Human NK Cell Progenitor Subsets. Int J Mol Sci. 2017;18: pubmed publisher
    ..Within the CD7? fraction, we focussed on the lineage potential of three subsets based on CD127 and CD117 expression and observed restricted lymphoid and biased NK cell potential amongst subsets...
  60. Gonzalez Y, Juarez E, Carranza C, Sada E, Pedraza Sánchez S, Torres M. Diminished effector and memory CD8+ circulating T lymphocytes in patients with severe influenza caused by the AH1N1 pdm09 virus. Virology. 2017;500:139-148 pubmed publisher
    ..CD62L+CCR7+, CD26 high CD62L+CD127+ or CD26 high CD45RO+CD57 low phenotypes than patients with mild ..
  61. Milford T, Su R, Francis O, Baez I, Martinez S, Coats J, et al. TSLP or IL-7 provide an IL-7R? signal that is critical for human B lymphopoiesis. Eur J Immunol. 2016;46:2155-61 pubmed publisher
    ..These data establish the importance of IL-7R? mediated signals for normal human B-cell production. ..
  62. Zhuang J, Wu L, Qian M, Cai P, Liu Q, Zhao G, et al. Variants of Interleukin-7/Interleukin-7 Receptor Alpha are Associated with Both Neuromyelitis Optica and Multiple Sclerosis Among Chinese Han Population in Southeastern China. Chin Med J (Engl). 2015;128:3062-8 pubmed publisher
    ..And the genotypic differences of IL-7 rs2887502 between MS and NMO indicated the different genetic backgrounds of these two diseases. ..
  63. Lee J, Yeh C, Jung C, Chen C, Du M, Yu H, et al. Skewed distribution of IL-7 receptor-?-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma. PLoS ONE. 2014;9:e85521 pubmed publisher
    ..A significantly higher frequency of CD127(lo) CCR7(-)CD45RA(-)CD8(+) T cells or CCR7(-)CD45RA(+)CD8(+) T cells among total CD8(+) T cells was found in ..
  64. Monti P, Brigatti C, Krasmann M, Ziegler A, Bonifacio E. Concentration and activity of the soluble form of the interleukin-7 receptor ? in type 1 diabetes identifies an interplay between hyperglycemia and immune function. Diabetes. 2013;62:2500-8 pubmed publisher
    ..The findings indicate that genetic, immunologic, and metabolic factors contribute to a dysregulation of the IL-7/IL-7 receptor pathway in T1D and identify a novel hyperglycemia-mediated interference of immune regulatory networks. ..
  65. Crawley A, Angel J. Expression of ?-chain cytokine receptors on CD8+ T cells in HIV infection with a focus on IL-7R? (CD127). Immunol Cell Biol. 2012;90:379-87 pubmed publisher
    ..be highlighting information about the IL-7 receptor (IL-7R) complex, which is composed of the ?(C) and the IL-7R? (CD127) chains...
  66. Jiang Q, Li W, Aiello F, Mazzucchelli R, Asefa B, Khaled A, et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev. 2005;16:513-33 pubmed
    ..There remain significant questions regarding IL-7 production and the major producing cells have yet to be fully characterized. ..
  67. Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, et al. Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Genes Immun. 2010;11:194-8 pubmed publisher
    ..Five SNPs within the genes AFF3, IL2/IL21, IL7R, CTLA4 and CD226, previously associated with multiple autoimmune diseases were genotyped, in a large data set of ..