Gene Symbol: IL1R2
Description: interleukin 1 receptor type 2
Alias: CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, interleukin-1 receptor type 2, CD121 antigen-like family member B, IL-1 type II receptor, IL-1R-beta, antigen CDw121b, interleukin 1 receptor type II variant 3, interleukin-1 receptor beta, interleukin-1 receptor type II, type II interleukin-1 receptor, beta
Species: human
Products:     IL1R2

Top Publications

  1. Akoum A, Lawson C, Herrmann Lavoie C, Maheux R. Imbalance in the expression of the activating type I and the inhibitory type II interleukin 1 receptors in endometriosis. Hum Reprod. 2007;22:1464-73 pubmed
    ..receptor type I (IL1R1), the signalling receptor that mediates cell activation by IL1, and IL1 receptor type II (IL1R2), a potent and specific down-regulator of IL1 action, in normal compared to endometriotic/endometrial tissues...
  2. Smith D, Hanna R, Moore H, Chen H, Farese A, MacVittie T, et al. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity. 2003;18:87-96 pubmed
    ..These findings suggest that the soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor, adding another layer of complexity to the regulation of IL-1 action...
  3. Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A. IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils. J Immunol. 2003;170:5999-6005 pubmed
    ..These results suggest that the decoy receptor IL-1RII can act as a scavenger of IL-1, representing a novel autoregulatory mechanism of the IL-1 system...
  4. Kondera Anasz Z, Mielczarek Palacz A, Switała J. [Significantly increased interleukin-1A and interleukin-1 soluble type II receptor levels in women with ovarian cancer]. Ginekol Pol. 2003;74:761-6 pubmed
    ..0001). Our results suggests that IL-1 alpha has a strong association with ovarian cancer. ..
  5. Seripa D, Matera M, Dal Forno G, Gravina C, Masullo C, Daniele A, et al. Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients. Neurobiol Aging. 2005;26:455-64 pubmed
  6. Re F, Muzio M, De Rossi M, Polentarutti N, Giri J, Mantovani A, et al. The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor. J Exp Med. 1994;179:739-43 pubmed
    ..The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex. ..
  7. Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, et al. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science. 1993;261:472-5 pubmed
    ..The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action. ..
  8. Liu C, Hart R, Liu X, Clevenger W, Maki R, De Souza E. Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 1996;271:20965-72 pubmed
    ..The alternative splicing of a primary transcript leading to a secreted protein provides a potentially important mechanism by which soluble IL-1RII can be produced. ..
  9. Colotta F, Saccani S, Giri J, Dower S, Sims J, Introna M, et al. Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. J Immunol. 1996;156:2534-41 pubmed
    ..The results show that, on exposure to diverse molecules with anti-inflammatory properties, mononuclear phagocytes express and release copious amounts of a novel version of the soluble IL-1 decoy RII. ..

More Information

Publications117 found, 100 shown here

  1. Yabluchanskiy A, Ma Y, DeLeon Pennell K, Altara R, Halade G, Voorhees A, et al. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. J Gerontol A Biol Sci Med Sci. 2016;71:475-83 pubmed publisher
    ..05) and seven anti-inflammatory genes (CCL1, CCL6, CCR1, IL11, IL1r2, IL8rb, and Mif; all p < .05)...
  2. Liu H, Xu G, Wang Y, Zhao H, Xiong S, Wu Y, et al. Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine/paracrine signaling loop. Biomaterials. 2015;49:103-12 pubmed publisher
    ..However, with BMSCs alone, the Il1r2 expression increased substantially, whereas Bmp2 expression exhibited a decrease rather than increase...
  3. Burakoff R, Chao S, Perencevich M, Ying J, Friedman S, Makrauer F, et al. Blood-based biomarkers can differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea. Inflamm Bowel Dis. 2011;17:1719-25 pubmed publisher
    ..The UC panel consisted of the four genes, CD300A, KPNA4, IL1R2, and ELAVL1; the CD panel comprised the four genes CAP1, BID, NIT2, and NPL...
  4. Takao T, Asanoma K, Kato K, Fukushima K, Tsunematsu R, Hirakawa T, et al. Isolation and characterization of human trophoblast side-population (SP) cells in primary villous cytotrophoblasts and HTR-8/SVneo cell line. PLoS ONE. 2011;6:e21990 pubmed publisher
    ..Microarray analysis revealed that IL7R and IL1R2 were exclusively expressed in SP cells and not in NSP cells...
  5. Lin S, Hsieh S, Lin Y, Lee C, Tsai M, Lai L, et al. A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity. Genes Immun. 2012;13:214-20 pubmed publisher
    ..The methylation statuses of the IL10 and IL1R2 genes were significantly reduced in the SLE patient samples relative to the healthy controls (age-adjusted odds ..
  6. Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, et al. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Sci Rep. 2018;8:14915 pubmed publisher
    ..From the 1,310 proteins analyzed by SOMAscan, a 5-protein signature (MMP3, ACY1, IL1R2, SERPINA4, CPB2) was able to discriminate severe rejection from both no-rejection and nonsevere rejection samples...
  7. Ocskó T, Tóth D, Hoffmann G, Tubak V, Glant T, Rauch T. Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis. Biochim Biophys Acta Gene Regul Mech. 2018;1861:1040-1047 pubmed publisher disease-specific repressor expression, and two anti-inflammatory factors interleukin 1 receptor 2 gene (IL1r2) and interleukin-1 receptor antagonist (IL1rn) were among the downregulated genes...
  8. Chang S, Su P, Lee T. Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway. Cytokine. 2009;45:32-8 pubmed publisher
    Expression of interleukin-1 receptor type II (IL1R2), a decoy receptor for pro-inflammatory interleukin 1 (IL-1), is enhanced by chronic exposure of the human uroepithelial cell line HUC-1 to arsenite...
  9. Sulik A, Kroten A, Wojtkowska M, Oldak E. Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. Scand J Immunol. 2014;79:68-72 pubmed publisher
    ..58) in the mumps meningitis group. The increased CSF cytokine levels are markers of meningeal inflammation, and each virus may cause a specific profile of the cytokine pattern. ..
  10. Schmidt A, Seifert G, Lauch R, Wolff Vorbeck G, Chikhladze S, Hopt U, et al. Organ-specific monocyte activation in necrotizing pancreatitis in mice. J Surg Res. 2015;197:374-81 pubmed publisher
    ..the blood, spleen, and liver and the subsequent determination of macrophages (F4/80) and their activation marker CD121b and MHCII (1Ad) were performed by fluorescence-activated cell sorting (FACS analyses)...
  11. Mantere O, Trontti K, García González J, Balcells I, Saarnio S, Mäntylä T, et al. Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. J Psychiatr Res. 2018;109:18-26 pubmed publisher
    ..significant upregulation of 11 immune system genes, including cytokines and cytokine receptors (SPP1, IL1R1, IL1R2), pattern recognition molecules (TLR1, TLR2 and TLR6, dectin-1/CLEC7A), molecules involved in apoptosis (FAS), and ..
  12. Bang S, Kim T, Lee B, Kwon E, Choi S, Lee K, et al. Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients. J Rheumatol. 2011;38:322-4 pubmed publisher
    ..Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22...
  13. Watanabe S, Iga J, Ishii K, Numata S, Shimodera S, Fujita H, et al. Biological tests for major depressive disorder that involve leukocyte gene expression assays. J Psychiatr Res. 2015;66-67:1-6 pubmed publisher
    ..Among 40 candidate genes, we identified a set of seven genes (PDGFC, SLC6A4, PDLIM5, ARHGAP24, PRNP, HDAC5, and IL1R2), each of which had expression levels that differed significantly between MDD and Control samples in the pilot ..
  14. Kutyrev I, Cleveland B, Leeds T, Wiens G. Proinflammatory cytokine and cytokine receptor gene expression kinetics following challenge with Flavobacterium psychrophilum in resistant and susceptible lines of rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2016;58:542-553 pubmed publisher
    ..il1b1, il1b2, il11a; acute phase response genes saa and drtp1; and putative cytokine receptors il1r1-like-b, il1r2, tnfrsf1a, tnfrsf9, tnfrsf1a-like-b increased following challenge while the transcript abundance of il1r-like-1 ..
  15. Doulias T, Quickert S, Weis S, Claus R, Kontopoulou K, Giamarellos Bourboulis E, et al. Low-dose hydrocortisone prolongs survival in a lethal sepsis model in adrenalectomized rats. J Surg Res. 2018;227:72-80 pubmed publisher
    ..Hydrocortisone increased the expression of TNF, Il1r2, and Hdac4 and decreased that of Dnmt3a. Bacterial burden of E...
  16. Aouizerat B, Dhruva A, Paul S, Cooper B, Kober K, Miaskowski C. Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms. J Pain Symptom Manage. 2015;50:599-614.e3 pubmed publisher
    ..Five different polymorphisms (IL1R2 rs4141134, IL6 rs4719714, IL17A rs8193036, NFKB2 rs1056890, and TNFA rs1800683) were associated with evening ..
  17. Freiberger S, Cheng P, Iotzova Weiss G, Neu J, Liu Q, Dziunycz P, et al. Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2. Mol Cancer Ther. 2015;14:2132-42 pubmed publisher
    ..We found the interleukin decoy receptors IL1R2 and IL13RA2 induced by ingenol mebutate in a PKC/MEK/ERK-dependent manner...
  18. Long F, Wang L, Yang L, Ji Z, Hu Y. Screening hub genes in coronary artery disease based on integrated analysis. Cardiol J. 2018;25:403-411 pubmed publisher
    ..Among MAPK signaling pathway, IL1R2, ARRB2 and PRKX were associated with CAD...
  19. Guo X, Zhang Y, Zheng L, Zheng C, Song J, Zhang Q, et al. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nat Med. 2018;24:978-985 pubmed publisher
    ..The gene signature of those activated tumor Tregs, which included IL1R2, correlated with poor prognosis in lung adenocarcinoma...
  20. Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, et al. IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages. J Immunol. 2015;194:3156-68 pubmed publisher
    ..In this study, we generated EGFP-knock-in Il1r2(-/-) mice and showed that they were highly susceptible to collagen-induced arthritis, an animal model for ..
  21. Schlüter T, Schelmbauer C, Karram K, Mufazalov I. Regulation of IL-1 signaling by the decoy receptor IL-1R2. J Mol Med (Berl). 2018;96:983-992 pubmed publisher
    ..The decoy receptor IL-1R2 (also known as CD121b) can suppress IL-1 maturation, sequester its active forms or hinder the signaling complex assembly...
  22. Gay C, Zak R, Lerdal A, Pullinger C, Aouizerat B, Lee K. Cytokine polymorphisms and plasma levels are associated with sleep onset insomnia in adults living with HIV/AIDS. Brain Behav Immun. 2015;47:58-65 pubmed publisher
    ..candidate genes involved in cytokine signaling: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL1R2, IL2, IL4, IL6, IL8, IL10, IL13, IL17A), nuclear factor of kappa light polypeptide gene enhancer in B cells (NFKB1 ..
  23. Walscheid K, Weinhage T, Foell D, Heinz C, Kasper M, Heiligenhaus A. Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis. Clin Immunol. 2016;: pubmed publisher
    ..09). Treatment reduced expression of MHCII, CD86, CD39 and CD124 (all p<0.05), whereas the percentage of CD121b-expressing monocytes was increased by week 6 (p=0.039)...
  24. Miaskowski C, Cataldo J, Baggott C, West C, Dunn L, Dhruva A, et al. Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers. Support Care Cancer. 2015;23:953-65 pubmed publisher
    ..g., participation with a FC). Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e...
  25. Rauschmayr T, Groves R, Kupper T. Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation. Proc Natl Acad Sci U S A. 1997;94:5814-9 pubmed
    ..Our transgenic mice may be a useful tool for determining the degree to which different types of cutaneous inflammation depend on the IL-1 system. ..
  26. Herrmann Lavoie C, Rao C, Akoum A. Chorionic gonadotropin down-regulates the expression of the decoy inhibitory interleukin 1 receptor type II in human endometrial epithelial cells. Endocrinology. 2007;148:5377-84 pubmed
    ..In view of IL-1's role as an embryonic signal, these data reveal a new mechanism by which hCG sustains human pregnancy and promotes embryonic growth. ..
  27. Fennell D, Myrand S, Nguyen T, Ferry D, Kerr K, Maxwell P, et al. Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory results from a phase II study. PLoS ONE. 2014;9:e107455 pubmed publisher
    ..protein B, aquaporin 4, TRAF2- and Nck-interacting kinase, Lysophosphatidylcholine acyltransferase 1, Interleukin 1 receptor type II, NK2 homeobox 1, ABO glycosyl-transferase); expression for all except IL1R2 correlated negatively with ..
  28. Alonso S, Mayol X, Nonell L, Salvans S, Pascual M, Pera M. Peripheral blood leucocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study. Colorectal Dis. 2017;19:O115-O125 pubmed publisher
    ..examples coding for secreted cytokines involved in tumour growth and invasion (S100P, HGF, MMP8, MMP9, PDGFC, IL1R2)...
  29. Cui Y, Chen W, Chi J, Wang L. Differential expression network analysis for diabetes mellitus type 2 based on expressed level of islet cells. Ann Endocrinol (Paris). 2016;77:22-9 pubmed publisher
    ..stimulus were enriched by 11 T2DM signature genes including ARG2, GLP1R, PFKFB2, PTPRN, ACSL5, CCR7, IL2RA, IL7R, IL1R2, IL1RL1 and CHST4. Finally, DEN including 11 signature genes and 491 edges was obtained...
  30. Alfaro E, Dhruva A, Langford D, Koetters T, Merriman J, West C, et al. Associations between cytokine gene variations and self-reported sleep disturbance in women following breast cancer surgery. Eur J Oncol Nurs. 2014;18:85-93 pubmed publisher
    ..Variations in three cytokine genes (i.e., IL1 receptor 2 (IL1R2), IL13, NFKB2) predicted latent class membership...
  31. Chen Z, Tao S, Gao Y, Zhang J, Hu Y, Mo L, et al. Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men. J Med Genet. 2013;50:794-801 pubmed publisher
    ..More importantly, the confirmation of the genetic loci for testosterone and SHBG suggests common genetic components shared among different ethnicities. ..
  32. Rizavi H, Ren X, Zhang H, Bhaumik R, Pandey G. Abnormal gene expression of proinflammatory cytokines and their membrane-bound receptors in the lymphocytes of depressed patients. Psychiatry Res. 2016;240:314-320 pubmed publisher
  33. Zhang Y, Sun J, Li F, Grogan T, Vergara J, Luan Q, et al. Salivary extracellular RNA biomarkers for insulin resistance detection in hispanics. Diabetes Res Clin Pract. 2017;132:85-94 pubmed publisher
    ..From the top ten candidates, six were individually validated (PRKCB, S100A12, IL1R2, CAMP, VPS4B, CAP1) (p<0.01) and yielded AUC values ranging from 0.66 to 0.76...
  34. van der Poll T, de Waal Malefyt R, Coyle S, Lowry S. Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 1997;175:118-22 pubmed
    ..IL-13 remained undetectable in the vast majority of patients and was not induced by endotoxin. Enhanced IL-13 production does not seem to be part of an inducible host defense mechanism during sepsis. ..
  35. Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, et al. The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. J Immunol. 1998;161:6871-7 pubmed
  36. Cannon J, Angel J, Abad L, Vannier E, Mileno M, Fagioli L, et al. Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 1997;17:253-61 pubmed
    ..Furthermore, the increased release of IL-1Ra and sIL-1RII by cells from CFS patients is consistent with the hypothesis that CFS is associated with chronic, low-level activation of the immune system. ..
  37. Sadouk M, Pelletier J, Tardif G, Kiansa K, Cloutier J, Martel Pelletier J. Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. Lab Invest. 1995;73:347-55 pubmed
    ..This phenomenon is probably secondary to an abnormality in the post-transcriptional regulation of the type I IL-1R. Although type II IL-1R is also expressed, its translation seems to be inoperative, or this receptor is already shed. ..
  38. Chen C, Zhang X, Wang Y. ANTXR2 and IL-1R2 polymorphisms are not associated with ankylosing spondylitis in Chinese Han population. Rheumatol Int. 2012;32:15-9 pubmed publisher
    ..We also assumed that IL-1? might not be the key factor in the immunogenesis of AS. ..
  39. Kovach M, Stringer K, Bunting R, Wu X, San Mateo L, Newstead M, et al. Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome. Respir Res. 2015;16:29 pubmed publisher
    ..Furthermore, we have identified a novel plasma biomarker candidate in ARDS that correlates with the severity of systemic illness and mortality. ..
  40. Grigoryev D, Cheranova D, Chaudhary S, Heruth D, Zhang L, Ye S. Identification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study. BMC Pulm Med. 2015;15:95 pubmed publisher
    ..66.6 % of these genes, were associated previously with lung injury and include the well known ARDS genes such as IL1R2 (P = 4.42 × 10(-19)), IL1β (P = 3...
  41. Giai C, González C, Sabbione F, Garofalo A, Ojeda D, Sordelli D, et al. Staphylococcus aureus Induces Shedding of IL-1RII in Monocytes and Neutrophils. J Innate Immun. 2016;8:284-98 pubmed publisher
    ..Modulation of decoy receptors during systemic S. aureus infection is proposed as a new strategy used by this bacterium to evade the immune response. ..
  42. Byun E, Gay C, Portillo C, Pullinger C, Aouizerat B, Lee K. Cytokine polymorphisms are associated with daytime napping in adults living with HIV. Sleep Med. 2017;32:162-170 pubmed publisher
    ..Genes included: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL1B, IL1R, IL1R2, IL2, IL4, IL6, IL8, IL10, IL13, IL17A), nuclear factors of kappa light polypeptide gene enhancer in B cells (..
  43. Yoshida K, Murayama M, Shimizu K, Tang C, Katagiri N, Matsuo K, et al. IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota. Biochem Biophys Res Commun. 2018;496:934-940 pubmed publisher
    Ulcerative colitis (UC) is an inflammatory disease of the colon. IL1R2, which encodes IL-1 receptor type 2 (IL-1R2), was reported as a risk gene for UC...
  44. Muller B, Peri G, Doni A, Perruchoud A, Landmann R, Pasqualini F, et al. High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration. J Leukoc Biol. 2002;72:643-9 pubmed
    ..The usefulness of IL-1RII, in particular as a potential marker for the activation of anti-inflammatory pathways or for responsiveness to anti-inflammatory agents such as glucocorticoid hormones, deserves further analysis. ..
  45. Baty F, Klingbiel D, Zappa F, Brutsche M. High-throughput alternative splicing detection using dually constrained correspondence analysis (DCCA). J Biomed Inform. 2015;58:175-185 pubmed publisher
    ..STAB2, PCDH15, HABP2), tumor aggressiveness (ARNTL2), apoptosis, proliferation and differentiation (PDE4D, FLT3, IL1R2), cell invasion (ETV1), as well as tumor growth (OLFM4, FGF14), tumor necrosis (AFF3) or tumor suppression (TUSC3, ..
  46. Chen Y, Chen T, Su M, Chen C, Chen K, Liou C, et al. Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype. Sleep. 2016;39:743-55 pubmed publisher
    ..However, a secondary outcome analysis showed that interleukin-1 receptor 2 (IL1R2) promoter methylation (-114 cytosine followed by guanine dinucleotide sequence [CpG] site) was decreased and IL1R2 ..
  47. Buescher E, Hair P. Human milk anti-inflammatory component contents during acute mastitis. Cell Immunol. 2001;210:87-95 pubmed
  48. Zheng Y, Humphry M, Maguire J, Bennett M, Clarke M. Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1?, controlling necrosis-induced sterile inflammation. Immunity. 2013;38:285-95 pubmed publisher
    ..Thus, we report a cell type-dependent process that fundamentally governs IL-1? activity postnecrosis and the mechanism allowing conditional release of this blockade. ..
  49. Smith D, Ketchem R, Moore H, Anderson Z, Renshaw B, Friend D, et al. A single amino acid difference between human and monkey interleukin (IL)-1beta dictates effective binding to soluble type II IL-1 receptor. J Biol Chem. 2002;277:47619-25 pubmed
    ..Structural and mutational analysis revealed that the unique sIL1R-II binding ability of human IL-1beta is due to a single amino acid difference compared with monkey IL-1beta. ..
  50. Kawaguchi Y, Nishimagi E, Tochimoto A, Kawamoto M, Katsumata Y, Soejima M, et al. Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. Proc Natl Acad Sci U S A. 2006;103:14501-6 pubmed
    ..These findings reveal that nuclear localization of pre-IL-1alpha depends on the binding to HAX-1 and that biological activities might be elicited by the binding to both HAX-1 and IL-1RII in SSc fibroblasts. ..
  51. Hou Z, Zhou J, Ma X, Fan L, Liao L, Liu J. Role of interleukin-1 receptor type II in the pathogenesis of endometriosis. Fertil Steril. 2008;89:42-51 pubmed
    ..These results suggest that IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis. ..
  52. Suzuki M, Ishihara Y, Kamiya Y, Koide M, Fuma D, Fujita S, et al. Soluble interleukin-1 receptor type II levels in gingival crevicular fluid in aggressive and chronic periodontitis. J Periodontol. 2008;79:495-500 pubmed
    ..sIL-1RII was detected more often in CP GCF than in AgP GCF, and there was no correlation between GCF sIL-1RII concentration and clinical parameters. ..
  53. Burzynski L, Humphry M, Bennett M, Clarke M. Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION. J Biol Chem. 2015;290:25188-96 pubmed publisher
    ..These data unravel the molecular mechanisms and interplay between damaged ECs and VSMCs that lead to activation of IL-1α and, thus, initiation of adaptive responses that cause graft rejection. ..
  54. Mora Buch R, Dotti I, Planell N, Calderón Gómez E, Jung P, Masamunt M, et al. Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis. Mucosal Immunol. 2016;9:950-9 pubmed publisher
    ..protein analysis of the intestinal mucosa revealed that the IL-1 decoy receptor, interleukin-1 receptor type 2 (IL1R2), was upregulated in remission compared with active UC and controls...
  55. Momenzadeh P, Mahmoudi M, Beigy M, Garshasbi M, Vodjdanian M, Farazmand A, et al. Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis. Rheumatol Int. 2016;36:429-35 pubmed publisher
    ..and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (..
  56. Fan H, Zhao G, Ren D, Liu F, Dong G, Hou Y. Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus. Immunol Lett. 2017;181:71-78 pubmed publisher
    ..OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with healthy donors, ..
  57. Pilkington S, Ogden S, Eaton L, Dearman R, Kimber I, Griffiths C. Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. Immunology. 2018;153:60-70 pubmed publisher
    ..Interleukin-1 receptor type 2 (IL1R2) gene expression was significantly increased in aged, but not young skin, after cytokine treatment...
  58. Fasano M, Cousart S, Neal S, McCall C. Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome. J Clin Invest. 1991;88:1452-9 pubmed
  59. Kharfi A, Boucher A, Akoum A. Abnormal interleukin-1 receptor type II gene expression in the endometrium of women with endometriosis. Biol Reprod. 2002;66:401-6 pubmed
    ..Defective IL-1RII gene expression during the early stages of endometriosis (stages I and II) may contribute to the etiology of the disease. ..
  60. Mehra M, Kobashigawa J, Deng M, Fang K, Klingler T, Lal P, et al. Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts. J Heart Lung Transplant. 2007;26:1255-63 pubmed
    ..Differential expression of the gene IL1R2 was significantly associated with future events...
  61. Näkki A, Kouhia S, Saarela J, Harilainen A, Tallroth K, Videman T, et al. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. BMC Med Genet. 2010;11:50 pubmed publisher
    ..As the observed association did not fully explain the linkage obtained in the previous study, it is plausible that also other variants in this genome region predispose to hand OA. ..
  62. McMahan C, Slack J, Mosley B, Cosman D, Lupton S, Brunton L, et al. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 1991;10:2821-32 pubmed
    ..Like the type I receptor, the human type II IL-1 receptor can bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1ra). Vaccinia virus contains an open reading frame bearing strong resemblance to the type II IL-1 receptor. ..
  63. Symons J, Young P, Duff G. Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist. Proc Natl Acad Sci U S A. 1995;92:1714-8 pubmed
    ..In addition, type II sIL-1R does not interfere with inhibition mediated by IL-1ra. ..
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    ..These results suggest that LC undergo changes in the cytokine receptor repertory during in vitro maturation. ..
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    b>Interleukin 1 receptor type 2 (IL1R2) regulates the inflammatory pathway that results in preterm delivery. We aim to investigate the impact of IL1R2 gene polymorphisms on the risk of preterm delivery...
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    ..These results indicate that cannabinoids prevent the impairment of network function produced by gp120 and, thus, might have therapeutic potential in HAD. ..
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    ..Variations in 2 cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain. ..
  68. Mar A, Chu C, Lee H, Chien C, Cheng J, Yang S, et al. Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. J Biol Chem. 2015;290:22212-24 pubmed publisher
    Interleukin-1 receptor type 2 (IL1R2) acts as a decoy receptor of exogenous IL-1; however, its intracellular activity is poorly understood...
  69. Kharfi A, Akoum A. Soluble interleukin-1 receptor type II blocks monocyte chemotactic protein-1 secretion by U937 cells in response to peripheral blood serum of women with endometriosis. Fertil Steril. 2002;78:836-42 pubmed
    ..These findings point toward a deficiency in the mechanisms involved in the down-regulation of IL-1 actions at the systemic level and reveal sIL-1RII as a key factor involved in that process. ..
  70. Libra M, Mangano K, Anzaldi M, Quattrocchi C, Donia M, Di Marco R, et al. Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders. Oncol Rep. 2006;15:1305-8 pubmed
    ..These data indicate that an attempt to increased circulating levels of IL-1 inhibitors occurs at different extent in the course of HCV infection as well as in its progression to NHL and/or MC. ..
  71. Vambutas A, DeVoti J, Goldofsky E, Gordon M, Lesser M, Bonagura V. Alternate splicing of interleukin-1 receptor type II (IL1R2) in vitro correlates with clinical glucocorticoid responsiveness in patients with AIED. PLoS ONE. 2009;4:e5293 pubmed publisher
    ..Type II (mIL1R2) transcript in PBMC as compared with controls, despite similar expression of the short soluble IL1R2 (sIL1R2) transcript (p<0.05)...
  72. Arend W, Malyak M, Smith M, Whisenand T, Slack J, Sims J, et al. Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J Immunol. 1994;153:4766-74 pubmed
    ..These results suggest that some IL-1 beta and IL-1ra may be bound in vivo to sIL-1RII and sIL-1RI, respectively, leading to underestimations of cytokine concentrations in body fluids when measured by ELISA. ..
  73. Kuhn P, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler S. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem. 2007;282:11982-95 pubmed
    ..This study reveals a similar proteolytic processing of IL-1R2 and APP and may provide an explanation for the increased IL-1R2 secretion observed in AD. ..
  74. van Minkelen R, de Visser M, Houwing Duistermaat J, Vos H, Bertina R, Rosendaal F. Haplotypes of IL1B, IL1RN, IL1R1, and IL1R2 and the risk of venous thrombosis. Arterioscler Thromb Vasc Biol. 2007;27:1486-91 pubmed
    ..The aim of this study was to investigate whether common variations in IL1B, IL1RN, IL1R1, and IL1R2 influence the risk of venous thrombosis...
  75. De Simone M, Arrigoni A, Rossetti G, Gruarin P, Ranzani V, Politano C, et al. Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells. Immunity. 2016;45:1135-1147 pubmed publisher
    ..and expressed on the cell surfaces specific signature molecules such as interleukin-1 receptor 2 (IL1R2), programmed death (PD)-1 Ligand1, PD-1 Ligand2, and CCR8 chemokine, which were not previously described on Treg ..
  76. Aissa A, Amaral C, Venâncio V, Machado C, Hernandes L, Santos P, et al. Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver. J Toxicol Environ Health A. 2017;80:1116-1128 pubmed publisher
    ..of Col3a1, Cdh5, Fabp3, Bax, and Hbegf and increased expression of Sell, Ccl5, Itga2, Birc3, Msr1, Bcl2a1a, Il1r2, and Selp...
  77. Bellehumeur C, Collette T, Maheux R, Mailloux J, Villeneuve M, Akoum A. Increased soluble interleukin-1 receptor type II proteolysis in the endometrium of women with endometriosis. Hum Reprod. 2005;20:1177-84 pubmed
    ..This may enhance IL-1-mediated activation of endometrial cells and contribute to the local immuno-inflammatory process observed in endometriosis patients. ..
  78. Lawson C, Bourcier N, Al Akoum M, Maheux R, Naud F, Akoum A. Abnormal interleukin 1 receptor types I and II gene expression in eutopic and ectopic endometrial tissues of women with endometriosis. J Reprod Immunol. 2008;77:75-84 pubmed
    ..IL1 triggers cell activation via its receptor type I (IL1R1), but its receptor type II (IL1R2) is known instead as a scavenger that buffers the cytokine's effects...
  79. Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole D, et al. High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Bone. 2010;47:975-81 pubmed publisher
    ..The results reported in this study suggest a role for CSF3R in the determination of bone density in women. ..
  80. Kamei H, Ishihara Y, Fuma D, Niwa T, Kamiya Y, Yokoi T, et al. Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. Arch Oral Biol. 2014;59:756-63 pubmed publisher
    ..We investigated the association between periodontitis and polymorphisms in the IL-1R1 and IL-1R2 genes (IL1R1 and IL1R2)...
  81. Liu X, Min L, Duan H, Shi R, Zhang W, Hong S, et al. Short hairpin RNA (shRNA) of type 2 interleukin-1 receptor (IL1R2) inhibits the proliferation of human osteosarcoma U-2 OS cells. Med Oncol. 2015;32:364 pubmed publisher
    Type 2 interleukin-1 receptor (IL1R2) is a member of the IL1 family. It has been reported that IL1R2 is expressed and plays important roles in several cancers. However, its potential role in human osteosarcoma has not been reported...
  82. Chen X, Chen X, Xu Y, Yang W, Wu N, Ye H, et al. Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease. Hum Genomics. 2016;10 Suppl 2:21 pubmed publisher
    ..MassARRAY platform, we measured the genotypes of six inflammation-related CpG-SNPs, including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666)...
  83. Kowalewska M, Herman A, Szczepkowska A, Skipor J. The effect of melatonin from slow-release implants on basic and TLR-4-mediated gene expression of inflammatory cytokines and their receptors in the choroid plexus in ewes. Res Vet Sci. 2017;113:50-55 pubmed publisher
    ..Il6), tumour necrosis factor α (Tnf) and their receptors: IL-1 receptor type I (Il1r1) and type II (Il1r2), IL-6 receptor (Il6r) and signal transducer (Il6st), TNFα receptor type I (Tnfrsf1a) and II (Tnfrsf1b) and ..
  84. Giri J, Wells J, Dower S, McCall C, Guzman R, Slack J, et al. Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. J Immunol. 1994;153:5802-9 pubmed
    ..We propose that increased cell surface expression and rapid release of preformed type II IL-1R from neutrophils, as a soluble IL-1 beta binding protein, represents a mechanism that has evolved for regulating IL-1 activity in sepsis. ..
  85. Fink G, Norman J. Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis. Cytokine. 1997;9:1023-7 pubmed
    ..These changes are indicative of pancreatitis severity and are not model dependent. ..
  86. Keita M, AinMelk Y, Pelmus M, Bessette P, Aris A. Endometrioid ovarian cancer and endometriotic cells exhibit the same alteration in the expression of interleukin-1 receptor II: to a link between endometriosis and endometrioid ovarian cancer. J Obstet Gynaecol Res. 2011;37:99-107 pubmed publisher
    ..Our findings highlight a common signature between endometrioid ovarian cancer and implants of endometriosis, which needs to be fully explored. ..
  87. Watson C, Cohain A, Griffin R, Chun Y, Grishin A, Hacyznska H, et al. Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions. Nat Commun. 2017;8:1943 pubmed publisher
    ..Key driver analysis identifies six genes (LTB4R, PADI4, IL1R2, PPP1R3D, KLHL2, and ECHDC3) predicted to causally modulate the state of coregulated networks in response to ..
  88. Lovenberg T, Crowe P, Liu C, Chalmers D, Liu X, Liaw C, et al. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). J Neuroimmunol. 1996;70:113-22 pubmed
    ..Together, these data demonstrate the existence of a novel protein that is related to the interleukin-1 receptor but does not bind IL-1 by itself. ..
  89. Pou J, Martinez Gonzalez J, Rebollo A, Rodriguez C, Rodríguez Calvo R, Martín Fuentes P, et al. Type II interleukin-1 receptor expression is reduced in monocytes/macrophages and atherosclerotic lesions. Biochim Biophys Acta. 2011;1811:556-63 pubmed publisher
    ..0005). Overall, our results suggest that under atherogenic conditions, there is a decrease in IL-1R2 expression in monocytes/macrophages and in the vascular wall that may facilitate IL-1 signaling. ..
  90. Lephart E, Andrus M. Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications. Exp Biol Med (Maywood). 2017;242:1482-1489 pubmed publisher
    ..beta1 and matrix metalloproteinase 9), anti-aging and aging genes, inflammatory biomarkers (interleukin-1A [IL1A], IL1R2, IL-6 and IL-8), nerve growth factor, and the antioxidants (proliferating cell nuclear antigen, catalase, ..
  91. Sebire G, Delfraissy J, Demotes Mainard J, Oteifeh A, Emilie D, Tardieu M. Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells. Cytokine. 1996;8:636-41 pubmed
    ..Finally, IL-1 receptor (IL-1r) type 1 and IL-1r type 2 were detected on human microglial cells but it was demonstrated that IL-13 and IL-4 acted as IL-6 inducers in human microglial cells independently of the IL-1/IL-1r pathway. ..
  92. Dale M, Nicklin M. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics. 1999;57:177-9 pubmed
    ..The contig contains the genes (cen --> tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 receptor (IL1R1), the IL-1 receptor-related protein 2 (IL1RL2), T1/ST2/fit-1 (IL1RL1), and the ..