IL1A

Summary

Gene Symbol: IL1A
Description: interleukin 1, alpha
Alias: IL-1A, IL1, IL1-ALPHA, IL1F1, IL-1 alpha, hematopoietin-1, interleukin-1 alpha, preinterleukin 1 alpha, pro-interleukin-1-alpha
Species: human

Top Publications

  1. ncbi Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals
    Carita Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Eur Cytokine Netw 14:168-71. 2003
  2. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
  3. doi Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
  4. doi Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
  5. ncbi Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
    C J March
    Nature 315:641-7. 1985
  6. pmc Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    Hajime Kono
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4470-8. 2010
  7. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
  8. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
  9. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
  10. pmc Circulating levels of interleukin-1 family cytokines in overweight adolescents
    Christian Jung
    Department of Internal Medicine I, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Mediators Inflamm 2010:958403. 2010

Detail Information

Publications240 found, 100 shown here

  1. ncbi Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals
    Carita Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Eur Cytokine Netw 14:168-71. 2003
    ..a study of 338 healthy blood donors whose CRP levels were determined and whose single nucleotide polymorphisms of IL1A(C/T)-889, IL1B(C/T)-511, IL1B(C/T) + 3954, IL6(G/C)-174 and ILRN (a VNTR) both genotyped and haplotyped...
  2. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  3. doi Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
    ..By this mechanism, stress-induced activation of caspase-1 directly links inflammation to cytoprotection, cell survival, and regenerative processes...
  4. doi Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
    ..These findings contribute to a better understanding of the host response to mycobacteria and provide the opportunity to explore potential, novel, therapeutic strategies against TB...
  5. ncbi Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
    C J March
    Nature 315:641-7. 1985
    ..The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity...
  6. pmc Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    Hajime Kono
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4470-8. 2010
    ..One key way they accomplish this important task is by producing IL-1alpha that is needed to initiate the inflammatory response...
  7. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  8. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  9. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
    ....
  10. pmc Circulating levels of interleukin-1 family cytokines in overweight adolescents
    Christian Jung
    Department of Internal Medicine I, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Mediators Inflamm 2010:958403. 2010
    ..Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents...
  11. ncbi Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk
    Jon Infante
    Neurology Service, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    Dement Geriatr Cogn Disord 23:215-8. 2007
    ..PARP-1 -410 and PARP-1 -1672 haplotypes were associated with an increased risk for AD (global haplotype association p value=0.019), and, in addition, PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A -889 allele 2...
  12. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  13. doi Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist
    Omid Khalilzadeh
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, Tehran, Iran
    Clin Experiment Ophthalmol 37:614-9. 2009
    ..This study aimed to investigate the association of GO with single-nucleotide polymorphisms (SNPs) in the IL-1 family (IL-1alpha, IL-1beta, IL-1 receptor [IL-1R] and IL-1 receptor antagonist [IL-1RA])...
  14. ncbi Transcriptional responses of human epidermal keratinocytes to cytokine interleukin-1
    Shoichiro Yano
    Department of Dermatology, NYU School of Medicine, New York 10016, USA
    J Cell Physiol 214:1-13. 2008
    ..In summary, IL-1 regulates a characteristic set of genes that define its specific contribution to inflammation and aberrant differentiation in skin diseases...
  15. ncbi Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice
    Yasuo Niki
    Department of Orthopedic Surgery, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 172:577-84. 2004
    ..These results suggest that MA-IL-1 contributes to synoviocyte self-proliferation and subsequent cartilage destruction in inflammatory joint disease such as rheumatoid arthritis...
  16. ncbi Ethnic-specific genetic associations with pulmonary tuberculosis
    Julio C Delgado
    Center for Blood Research and Departments of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 186:1463-8. 2002
    ....
  17. pmc Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men
    Jaro Karppinen
    Finnish Institute of Occupational Health, Helsinki, Finland
    Eur Spine J 18:1963-70. 2009
    ..However, their pathophysiology remains largely unknown. A previous study of Northern Finnish males implicated that IL1A and MMP3 polymorphisms play a role in type II Modic changes...
  18. doi Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway
    Shih Yu Chang
    Institute of Biopharmaceutical Sciences, National Yang Ming University, Taipei, Taiwan, ROC
    Cytokine 45:32-8. 2009
    ..Because SIP-1 is a repressor of COL1A1-induced E-cadherin expression, the present results suggest that IL1R2 overexpression is likely through activation of the pIL-1alpha pathway to enhance cell migration...
  19. ncbi Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components
    Constantinos Brikos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
    Mol Cell Proteomics 6:1551-9. 2007
    ..The only component of the IL-1RI signaling complex that dissociated is IRAK-1. Our study is therefore the first detailed description of the endogenous IL-1RI complex...
  20. ncbi Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis
    Beata Hutyrova
    Departments of Immunology, Biology, and Respiratory Medicine, Palacky University, Olomouc, Czech Republic
    Am J Respir Crit Care Med 165:148-51. 2002
    ..Further population studies are warranted to confirm the observed association between sarcoidosis and the IL-1alpha polymorphism and also to explore mechanisms of IL-1alpha -889 participation in aberrant immune response in sarcoidosis...
  21. doi Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1117-27. 2009
    ..In conclusion, IL-1alpha stimulates human CMF to express IL-1beta, TNF-alpha, and IL-6 via specific signaling pathways, responses that are unaffected by IL-10 exposure...
  22. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
    ....
  23. doi Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population
    Mingqing Xu
    School of Public Health, Harvard University, Boston, MA 02115, USA
    Schizophr Res 120:131-42. 2010
    Recent genetic studies have revealed that the Interleukin-1 (IL1) gene complex (IL1 alpha, IL1 beta and IL1 receptor antagonist) is associated with schizophrenia, but contradictory findings have also been reported...
  24. doi Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis
    Murray C H Clarke
    Division of Cardiovascular Medicine, University of Cambridge, Box 110, ACCI, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Circ Res 106:363-72. 2010
    ....
  25. ncbi Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Eur Cytokine Netw 16:253-60. 2005
    ..We designed a broad study to investigate the susceptibility and prognostic implications of the genetic variation in IL-1alpha, IL-1beta and IL-6 in breast carcinoma...
  26. ncbi Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells
    Maria Carmela Latella
    John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Immunol Invest 38:203-19. 2009
    ..No association was found between block "B" IL-1B haplotypes or IL-1A and IL-RA polymorphisms and risk of MI. IL-1B haplotypes influence the inflammatory response of human mononuclear cells to LPS and affect the risk of MI at young age...
  27. ncbi Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis
    M J Carter
    The Gastroenterology and Liver Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Genes Immun 5:8-15. 2004
    ..IL1RN, IL1A and IL1B genotypes were determined using restriction-enzyme analysis...
  28. doi Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy
    Won Ho Hahn
    Department of Pediatrics, East West Kidney Diseases Research Institute, School of Medicine, Kyung Hee University, Dondaemun gu, Hoegi dong 1, Seoul, 130 701, Korea
    Pediatr Nephrol 24:1329-36. 2009
    ..SNPs of the IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (RN) genes (IL1A, IL1B, and IL1RN, respectively) were analyzed in 182 patients with childhood IgAN and in 500 healthy controls...
  29. doi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  30. doi Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study
    Pilar A Saiz
    Department of Psychiatry, School of Medicine, Centro de Investigación Biomédica en Red de Salud Mental, University of Oviedo, Julian Claveria 6 3, Oviedo, Spain
    Alcohol Clin Exp Res 33:2147-53. 2009
    ....
  31. doi Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein
    S Lee
    Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, University of Western Australia, Perth, Australia
    Tissue Antigens 72:67-71. 2008
    Alleles of IL1A-889(C>T) and IL1A+4845(G>T) are in linkage disequilibrium. Interleukin 1alpha (IL-1alpha) is produced as a precursor protein and cleaved at positions 117-118 by calpain, generating a mature protein for export...
  32. ncbi Salivary enzyme levels after scaling and interleukin-1 genotypes in Japanese patients with chronic periodontitis
    Hiromasa Yoshie
    Department of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 78:498-503. 2007
    ....
  33. pmc Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Matrix Biol 29:613-20. 2010
    ..In summary, IL-1α induces a distinct pattern of ECM protein and protease expression in human CMF, in part regulated by distinct p38 MAPK subtypes, affirming the key role of IL-1α and CMF in post-infarction cardiac remodeling...
  34. pmc Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production
    D Schols
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Virol 70:4953-60. 1996
    ....
  35. ncbi The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function
    David Richard Schmidt
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Ave, Madison, WI 53705, USA
    Biomaterials 28:371-82. 2007
    ..This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function...
  36. ncbi Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men
    Isabel J Pastor
    Unidad de Medicina Molecular, Departamento de Medicina, Salamanca, Spain
    Alcohol Alcohol 40:181-6. 2005
    ..We analysed the distribution of single nucleotide polymorphisms (SNPs) located in the IL1A, IL1B, IL1R1 and IL1RN genes in alcoholic and non-alcoholic Spanish subjects.
  37. doi Interleukin-1 region meta-analysis with osteoarthritis phenotypes
    G Moxley
    Virginia Commonwealth University, Richmond, VA 23298 0263, USA
    Osteoarthritis Cartilage 18:200-7. 2010
    ..Several research groups have examined osteoarthritis (OA) association with Interleukin-1 (IL-1) region markers and haplotypes. The results have been suggestive for hand OA, negative for knee OA, and conflicting for hip OA...
  38. doi The role of interleukin-1 in wound biology. Part II: In vivo and human translational studies
    Yajing Hu
    Department of Anesthesia, Stanford University, Stanford, USA
    Anesth Analg 111:1534-42. 2010
    ..We further investigate the role of IL-1 in incisional wound biology and its effect on wound chemokine production in vivo and whether this mechanism could be active in human subjects...
  39. doi Investigation of the interleukin-1 gene cluster polymorphisms in Jordanian patients with chronic and aggressive periodontitis
    Jumana A Karasneh
    Department of Oral Medicine and Oral Surgery, Dental School, Jordan University of Science and Technology, Irbid, Jordan
    Arch Oral Biol 56:269-76. 2011
    ..IL-1 gene polymorphisms have been associated with the IL-1 level. The aim of this study was to investigate if IL-1 gene cluster polymorphisms are associated with chronic (CP) and aggressive (AgP) periodontitis in a Jordanian population...
  40. ncbi Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis
    Esra Guzeldemir
    Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkey
    J Oral Sci 50:151-9. 2008
    ..Moreover, IL-1 gene polymorphisms appear to have a role in susceptibility to LAgP, and the above-mentioned genotypes could be an important risk factor for LAgP in the Turkish population...
  41. pmc Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts
    S Kumar
    Department of Biological Sciences, State University of New York, Albany 12222
    Proc Natl Acad Sci U S A 89:4683-7. 1992
    ..These data indicate that IL-1 is "constitutively" produced by aging fibroblasts and that IL-1 induces the expression of specific proteins in these cells. The mechanism for this constitutive production of IL-1 is explored in this paper...
  42. ncbi Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy
    Patricia K Constantini
    Institute of Liver Studies, King s College Hospital, London SE5 9RS, UK
    Liver 22:404-12. 2002
    ..The aim of this study was to investigate the relationship between a number of these candidate genes and both spontaneous and treatment related clearance of hepatitis C virus infection...
  43. ncbi Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Psychiatry Clin Neurosci 61:364-9. 2007
    Interleukin-1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia...
  44. pmc Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts
    Vegard Tjomsland
    Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Neoplasia 13:664-75. 2011
    ..e. CAFs, is one essential factor in the formation of the inflammatory tumor environment, and we propose that neutralization of the IL-1α signaling might be a potential therapy for this cancer...
  45. ncbi Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis
    B Yucesoy
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 172:75-82. 2001
    ..These studies suggest that gene-environment interactions involving cytokine polymorphisms play a significant role in silicosis by modifying the extent of and susceptibility to disease...
  46. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001
    ..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis...
  47. ncbi SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E8
    J Biol Chem 280:8397-406. 2005
    ..Focal adhesions co-localizing with the endoplasmic reticulum may provide molecular staging sites required for ERK activation...
  48. doi IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes
    Neil E Humphreys
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Eur J Immunol 39:1036-45. 2009
    ....
  49. pmc Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease
    P Bosco
    IRCCS Associazione Oasi Maria SS, Institute for Research on Mental Retardation and Brain Aging, Troina, Italy
    J Neurol Neurosurg Psychiatry 75:1036-8. 2004
    ..Genetic polymorphisms of APO-E, homocysteine, and the IL-1 gene cluster (IL-1A, IL-1B, receptor antagonist IL-1RN) are associated with sporadic Alzheimer's disease and may involve interdependent pathways of neuronal toxicity...
  50. ncbi Induction of interleukin-1 and glucocorticoid hormones by HIV promotes viral replication and links human chromosome 2 to AIDS pathogenesis: genetic mechanisms and therapeutic implications
    P A Corley
    Med Hypotheses 48:415-21. 1997
    ..IL-1 also adversely affects acquired immune deficiency syndrome-related Kaposi's sarcoma. Several genetic treatments for human immunodeficiency virus infection are proposed...
  51. doi Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis
    P Harrison
    Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK
    Rheumatology (Oxford) 47:1768-70. 2008
    ..This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies...
  52. pmc Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
    Mukundan Attur
    Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Ann Rheum Dis 69:856-61. 2010
    ..A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs...
  53. doi Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain
    M C Déniz-Naranjo
    Department of Immunology, Hospital Universitario Dr Negrín de Gran Canaria, Las Palmas de Gran Canaria, Spain
    Eur J Neurol 15:1080-4. 2008
    ..Based on these data, our work attempts to investigate the effects of some promoter polymorphisms of pro-inflammatory cytokines [interleukin (IL)-1 alpha and IL-1 beta] on AD...
  54. ncbi [Association between interleukin-1 alpha-889 C/T polymorphism and Alzheimer's disease in Chinese Han population]
    Yong tao Zhou
    Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:186-90. 2006
    ..To explore the possible association between interleukin-1 alpha-889C/T (IL-1 alpha-889 C/T) polymorphism and Alzheimer's disease (AD) in Chinese Han population...
  55. doi IL-1 gene cluster is not linked to aggressive periodontitis
    C Scapoli
    Department of Biology and Evolution, University of Ferrara, Corso Ercole I d Este 32, I 44100 Ferrara, Italy
    J Dent Res 89:457-61. 2010
    ..No association between AgP and IL1A, IL1B, and IL1RN genes was found in either single-point or haplotype analyses...
  56. ncbi Interleukin 1alpha, interleukin 1beta and interleukin 1 receptor gene polymorphisms in psoriatic arthritis
    J S Ravindran
    Royal National Hospital for Rheumatic Diseases, Bath, UK
    Rheumatology (Oxford) 43:22-6. 2004
    ..To investigate polymorphisms of interleukin (IL) 1alpha, IL-1beta and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement...
  57. ncbi The balance between IL-1 and IL-1Ra in disease
    William P Arend
    B115 Division of Rheumatology, Health Sciences Centre, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine Growth Factor Rev 13:323-40. 2002
    ..Treatment of RA with daily subcutaneous injections of recombinant IL-1Ra protein has been shown to be efficacious. Gene therapy approaches with IL-1Ra are being evaluated for the treatment of RA and other human diseases...
  58. ncbi A sequence-based map of the nine genes of the human interleukin-1 cluster
    Martin J H Nicklin
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Genomics 79:718-25. 2002
    ..Previous work has placed the novel genes close to or within the same cluster as IL1A, IL1B, and IL1RN, which occupy an approximately 400-kb interval on chromosome 2...
  59. ncbi Interleukin-1 and interleukin-6 gene polymorphisms and the risk of breast cancer in caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Austria
    Clin Cancer Res 11:5718-21. 2005
    ..Interleukin (IL)-1 and IL-6 are crucially involved in breast carcinogenesis. Whether polymorphisms of the genes encoding IL-1 (IL1) and IL-6 (IL6) also influence breast cancer risk is unknown.
  60. ncbi Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes
    Juan Kong
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 176:3780-7. 2006
    ..Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes...
  61. ncbi Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis
    John Loughlin
    Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Arthritis Rheum 46:1519-27. 2002
    ..To investigate whether the interleukin-1 (IL-1) ligand gene cluster at 2q13 encodes for genetic susceptibility to primary osteoarthritis (OA)...
  62. pmc A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression
    Bo Hu
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Biomedical Science Tower South Wing, 7th Floor, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:10008-13. 2003
    ....
  63. ncbi Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease
    F L Sciacca
    Department of Neuroscience, Neuroimmunology Unit, AUSL2, via Cusmano 3, Caltanissetta, Italy
    Neurobiol Aging 24:927-31. 2003
    ..0001; odds ratio for early onset, 7.4). These data further support a role for inflammation-related genes in AD or indicate linkage disequilibrium with an unknown chromosome 2 locus...
  64. ncbi Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer
    Hirozumi Sawai
    Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Oncology 65:167-73. 2003
    ....
  65. ncbi The IL1A (-889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals
    P R Moreira
    Laboratory of Cell Cell Interactions, Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Periodontal Res 42:23-30. 2007
    ..The C/T polymorphism at position -889 of the IL1A gene influences interleukin-1alpha expression, with the T allele inducing higher expression...
  66. ncbi Polymorphism in the IL-1alpha (-889) locus associated with elevated risk of primary open angle glaucoma
    Chun Yuan Wang
    Department of Ophthalmology, Taichung Veterans General Hospital, National Yang Ming University, Taichung, Taiwan, Republic of China
    Mol Vis 12:1380-5. 2006
    ..In this report we have explored the possible association between the IL-1alpha (-889) polymorphism and the development of POAG...
  67. ncbi Association of an interleukin 1 alpha polymorphism with Alzheimer's disease
    Y Du
    Departments of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Neurology 55:480-3. 2000
    ..The IL-1A(-889) allele 2 polymorphism may be associated with AD pathogenesis...
  68. pmc The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription
    Ariel Werman
    Department of Microbiology and Immunology, Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 101:2434-9. 2004
    ..Because this mechanism of action is not affected by extracellular inhibitors, reducing intracellular functions of IL-1alpha might prove beneficial in some inflammatory conditions...
  69. ncbi Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis
    A J P Smith
    University of Bristol Department of Pathology and Microbiology, Homoeopathic Hospital Site, Cotham, Bristol, UK
    Genes Immun 5:451-60. 2004
    ..We explored the linkage between nine polymorphic loci in the IL1R1 promoter, eight in the IL1A-IL1B-IL1RN gene complex, and their association with osteoarthritis (OA), a common complex disease associated with ..
  70. ncbi Relations between interleukin-1, its receptor antagonist gene polymorphism, and bone mineral density in postmenopausal Korean women
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University Hospital, 28 Yeunkeun dong, Chongno Gu, Seoul 110 744, Korea
    J Bone Miner Metab 24:53-7. 2006
    ..These data suggest that IL-1ra gene VNTR polymorphism is a genetic factor that may affect BMD in Korean women...
  71. pmc Cytokine production by whole blood cells: relationship to interleukin gene polymorphism and bone mass
    Jung Gu Kim
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    J Korean Med Sci 20:1017-22. 2005
    ..In conclusion IL-1beta may regulate bone metabolism at femoral neck, and the IL system polymorphism do not affect the production of ILs by whole blood cells...
  72. doi Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty
    Andrew Gordon
    University of Sheffield, and Academic Unit of Bone Metabolism, Northern General Hospital, Sheffield, UK
    Arthritis Rheum 58:3157-65. 2008
    ....
  73. ncbi Association analysis between interleukin-1 family polymorphisms and generalized aggressive periodontitis in a Chinese population
    Qi Yan Li
    Department of Periodontology, School of Stomatology, Peking University, Beijing, China
    J Periodontol 75:1627-35. 2004
    ..The intent of this investigation was to study whether specific interleukin (IL)-1 genotypes and/or alleles could be used to predict susceptibility to generalized AgP (GAgP) in Chinese...
  74. ncbi Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease
    S Shirodaria
    Department of Adult Oral Health, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, UK
    J Dent Res 79:1864-9. 2000
    ..These results suggest a mechanism whereby this genetic polymorphism acts to modulate IL-1alpha protein production and may influence the pathogenesis of periodontal disease by affecting the extent of IL-1-associated bystander damage...
  75. ncbi Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis
    Anne Havemose-Poulsen
    Department of Periodontology, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 78:475-92. 2007
    ..An important question to address is how interleukin (IL)-1 polymorphisms affect the cytokine profiles of patients with such diseases...
  76. pmc Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer
    Suresh Kumar
    Departments of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Pathol 163:2531-41. 2003
    ..Taken together, these results suggest that cancer cell-derived cytokines, such as IL-1 alpha, induce cachexia by affecting leptin-dependent metabolic pathways...
  77. ncbi IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset
    Francesca L Sciacca
    Neuromuscular Disease Department, National Neurological Institute, C Besta, Milan, Italy
    J Neuroimmunol 122:94-9. 2002
    ..022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2...
  78. ncbi Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
    T Uno
    First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Horm Metab Res 40:8-12. 2008
    ..These results suggest that the IL-1alpha-mediated deterioration of insulin signaling is largely due to the IL-6 production and SOCS3 induction in 3T3-L1 adipocytes...
  79. ncbi Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients
    Malek Sezgin
    Department of Physical Medicine and Rehabilitation, Medical Faculty of Mersin University, Mersin, Turkey
    Clin Invest Med 30:E86-92. 2007
    To examine whether polymorphisms of the interleukin 1 receptor antagonist (IL1RN), interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B) genes are markers of genetic susceptibility to knee osteoarthritis in Turkish patients.
  80. ncbi C-reactive protein levels are influenced by common IL-1 gene variations
    Peter Berger
    Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cytokine 17:171-4. 2002
    ..These data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography...
  81. ncbi Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese
    Hideaki Tai
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    J Clin Periodontol 29:882-8. 2002
    ....
  82. ncbi Polymorphisms of the interleukin-1 gene cluster and ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria
    J Soc Gynecol Investig 9:386-90. 2002
    ..Interleukin-1 (IL-1) is known to be critically involved in ovarian carcinogenesis. We investigated a panel of polymorphisms of the IL-1 and the IL-1 receptor antagonist (IL-1 RA) genes in patients with ovarian cancer...
  83. ncbi Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1 alpha
    Roberto Dominici
    Institute of Biomedical Sciences and Department of Neurology, Ospedale Luigi Sacco, Milan, Italy
    Immunogenetics 54:82-6. 2002
    ..The TT genotype significantly increased the transcriptional activity of the IL-1 alpha gene with respect to the CC genotype. A slight increase of the IL-1 alpha mRNA and protein levels was also observed in the plasma...
  84. ncbi Association between the interleukin-1 family gene cluster and psoriatic arthritis
    Proton Rahman
    Memorial University of Newfoundland, St Clare s Mercy Hospital, St John s, Newfoundland, Canada
    Arthritis Rheum 54:2321-5. 2006
    ..The loci in the IL1 gene cluster have recently been associated with ankylosing spondylitis (AS)...
  85. ncbi Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk
    G Moxley
    Virginia Commonwealth University, Richmond, VA, USA
    Osteoarthritis Cartilage 15:1106-12. 2007
    ..To assess osteoarthritis (OA) association with the human interleukin-1 (IL-1) region...
  86. ncbi Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population
    J Javor
    Department of Immunology, School of Medicine, Comenius University, Saskinova 4, 811 08 Bratislava, Slovakia
    Int J Immunogenet 34:273-80. 2007
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases...
  87. ncbi Normal tension glaucoma is not associated with the interleukin -1alpha (-889) genetic polymorphism
    Chun Yuan Wang
    Department of Ophthalmology, Taichung Veterans General Hospital, National Yang Ming University, Taiwan, Republic of China
    J Glaucoma 16:230-3. 2007
    ..IL-1alpha (-889) T allele polymorphism has been found to increase the risk of developing Alzheimer disease. The aim of this study was to test in a Chinese cohort the hypothesis that IL-1alpha (-889) polymorphism is associated with NTG...
  88. ncbi Lack of association between interleukin-1 gene cluster polymorphisms and glaucoma in Chinese subjects
    Alicia C S How
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 48:2123-6. 2007
    ..The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese patients with either POAG or primary-angle closure glaucoma (PACG)...
  89. ncbi Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity
    Yasushi Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    Immunogenetics 59:441-8. 2007
    We previously demonstrated the association of IL1A gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic sclerosis (SSc) patients...
  90. pmc Interleukin-1 receptor antagonist haplotype associated with prostate cancer risk
    F Lindmark
    Department of Radiation Sciences Oncology, Umea University, Sweden
    Br J Cancer 93:493-7. 2005
    b>IL1-RN is an important anti-inflammatory cytokine that modulate the inflammation response by binding to IL1 receptors, and as a consequence inhibits the action of proinflammatory cytokines IL1alpha and IL1beta...
  91. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  92. ncbi Association of IL1A gene polymorphisms with susceptibility to and severity of systemic sclerosis in the Japanese population
    Yasushi Kawaguchi
    Institute of Radiology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Arthritis Rheum 48:186-92. 2003
    To analyze the frequencies of haplotypes of single-nucleotide polymorphisms (SNPs) of the IL1A gene (at -889, +4729, and +4845) in patients with systemic sclerosis (SSc) and in healthy control subjects, and to determine whether the IL1A ..
  93. ncbi Endogenous interleukin-1 alpha promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells
    Kelly Schultz
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 8486, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 292:H2927-34. 2007
    ....
  94. doi Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population
    Kim W Carter
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Hum Genet 124:199-206. 2008
    ....
  95. ncbi Endotoxin-activated cultured neonatal rat cardiomyocytes express functional surface-associated interleukin-1alpha
    Elena Westphal
    Martin Luther Universitat Halle Wittenberg, Universitätsklinik und Poliklinik für Innere Medizin III, Halle, Germany
    J Endotoxin Res 13:25-34. 2007
    ....
  96. ncbi Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants?
    Marina A Rogers
    Department of Pathology, University of Western Australia, Perth, Australia
    J Periodontal Res 37:37-41. 2002
    ..IL-1A(-889), IL-1B(+3953) and the composite genotype also showed no association with failure of dental implants...
  97. doi Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Pediatr Diabetes 9:9-16. 2008
    ....
  98. pmc Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    Sung Kyun Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 6:12. 2006
    ..that beta-defensins have antimicrobial activity against nontypeable Haemophilus influenzae (NTHi) and that interleukin 1 alpha (IL-1 alpha) up-regulates the transcription of beta-defensin 2 (DEFB4 according to new nomenclature of the ..
  99. ncbi A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes
    M J Nicklin
    Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, United Kingdom
    Genomics 19:382-4. 1994
    ..The genes (IL1A, IL1B, and IL1RN, respectively) were found to map to a common restriction fragment of approximately 430 kb that is ..
  100. ncbi Interleukin-1-induced NF-kappaB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells
    Melvyn S Soloff
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Mol Hum Reprod 12:619-24. 2006
    ..Interleukin-1alpha (IL1A) treatment of cultured human myometrial cells has previously been shown to reduce steady-state levels of OTR mRNA...
  101. ncbi IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR
    Esther A Suswam
    Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA
    Int J Cancer 113:911-9. 2005
    ..the destabilizing factor KSRP. In conclusion, IL-1beta is a potent cytokine stimulus for IL-8 RNA stabilization in breast cancer cells, possibly by enhanced binding of cytoplasmic HuR to the 3'UTR...

Research Grants67

  1. ETHANOL AND OSTEOBLASTOGENESIS--ROLES OF IL1 AND TNF
    CHARLES LUMPKIN; Fiscal Year: 2002
    ..abstract_text> ..
  2. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2010
    ..metabolic syndrome, chronic inflammation, sleepiness, etc;can be elicited by administration of interleukin-1 beta (IL1) or related cytokines or can be prevented by blocking them...
  3. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2010
    ..Cytokines (particularly IL1) and bacterial lipopolysaccharides (LPS) and muramyl dipeptide (MDP) have been implicated in Crohn's ..
  4. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark Kidd; Fiscal Year: 2009
    ..Cytokines (particularly IL1) and bacterial lipopolysaccharides (LPS) and muramyl dipeptide (MDP) have been implicated in Crohn's ..
  5. ROLES OF ENDOGENUOUS ALPHA-MSH IN FEVER & IMMUNITY
    JEFFREY TATRO; Fiscal Year: 1993
    The melanotropic neuropeptide, alpha-MSH, is known to inhibit interleukin 1 (IL1)-induced fever in the brain and systemic immune responses...
  6. ROLES OF ENDOGENOUS ALPHA MSH IN FEVER AND IMMUNITY
    JEFFREY TATRO; Fiscal Year: 2003
    ..roles of specific MCR subtypes, in mediating melanocortin-induced inhibition of endotoxin (LPS) and interleukin-1 (IL1) actions in the brain; and the role of hypothalamic neurons producing a novel endogenous MCR antagonist (agouti-..
  7. SUPPRESSION OF P450 GENES BY INFLAMMATORY MEDIATORS
    Edward Morgan; Fiscal Year: 1993
    ..There is evidence that the cytokines interleukin-1 (IL1) and interleukin-6 (IL6), as well as interferons and glucocorticoids, all may contribute as blood-borne mediators ..
  8. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2009
    ..effects of morphine, through the release of proinflammatory cytokines: tumor necrosis factor (TNF), interleukin-1 (IL1) & interleukin-6 (IL6)...
  9. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..effects of morphine, through the release of proinflammatory cytokines: tumor necrosis factor (TNF), interleukin-1 (IL1) &interleukin-6 (IL6)...
  10. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2009
    ..effects of morphine, through the release of proinflammatory cytokines: tumor necrosis factor (TNF), interleukin-1 (IL1) & interleukin-6 (IL6)...
  11. Pain control via spinal interleukin-10 gene therapy
    ERIN MILLIGAN; Fiscal Year: 2007
    ..enhanced pain via the release of proinflammatory cytokines (PlCs): tumor necrosis factor (TNF), interleukin-1 (IL1) & interleukin-6 (IL6)...
  12. AUTOCRINE ROLE OF CYTOKINES IN VASCULAR SMOOTH MUSCLE
    Debbie Beasley; Fiscal Year: 1993
    ..The proposed research will test the hypotheses that autocrine or paracrine actions of IL1 and/or IL6 produced within blood vessels modulate systemic vascular resistance and local blood flow in vivo...
  13. Pain control via spinal interleukin-10 gene therapy
    ERIN MILLIGAN; Fiscal Year: 2007
    ..enhanced pain via the release of proinflammatory cytokines (PlCs): tumor necrosis factor (TNF), interleukin-1 (IL1) & interleukin-6 (IL6)...
  14. AUTOCRINE ROLE OF CYTOKINES IN VASCULAR SMOOTH MUSCLE
    Debbie Beasley; Fiscal Year: 2005
    ..that the precursor form of IL1alpha is a potent membrane-associated growth factor for human VSMC (HVSMC), and that IL1-induced proliferation involves activation of TRAF6, NIK, and IKKs, leading to the persistent activation of NF-..
  15. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta...
  16. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta...
  17. FETAL ALCOHOL EXPOSURE--NEUROIMMUNE INTERACTIONS
    Anna Taylor; Fiscal Year: 2001
    ..response induced by a pathogen product, lipopolysaccharide (LPS), and one of the cytokines, interleukin-1 beta (IL1), induced by LPS. Moreover, maternal adrenalectomy was found to prevent the blunted febrile response...