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| IL17RBSummaryGene Symbol: IL17RB Description: interleukin 17 receptor B Alias: CRL4, EVI27, IL17BR, IL17RH1, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17RB, IL-17Rh1, cytokine receptor CRL4, cytokine receptor-like 4, interleukin 17 receptor homolog 1, interleukin 17B receptor, interleukin-17 receptor B, interleukin-17B receptor Species: human Top Publications
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Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulationH Wang
The Unit for Clinical Systems Biology, Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Sahlgrenska Academy, University of Gothenburg, and The Pediatric Allergy Unit, The Queen Silvia Children s Hospital, Gothenburg, Sweden
Clin Exp Allergy 40:1194-202. 2010..Allergen-challenged peripheral blood mononuclear cells (PBMCs) provide a human in vitro model of how antigen-presenting cells, CD4+ T cells and effector cells such as basophils interact in allergic inflammation...
Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcomePiiha Lotta Jerevall
Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, Linkoping, Sweden
Breast Cancer Res Treat 107:225-34. 2008The two-gene expression ratio HOXB13:IL17BR has been proposed to predict the outcome of tamoxifen-treated breast cancer patients. We intended to examine whether this ratio can predict the benefit of 5 years vs...- Evi27 encodes a novel membrane protein with homology to the IL17 receptorE Tian
Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Oncogene 19:2098-109. 2000b>Evi27 is a common site of retroviral integration in BXH2 murine myeloid leukemias... 
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexTarek Abbas
Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Genes Dev 22:2496-506. 2008..Antigen (PCNA) promotes the DNA damage-induced degradation of the replication initiation factor Cdt1 via the CRL4(Cdt2) E3 ubiquitin ligase complex...- Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damageHisanobu Oda
Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
Mol Cell 40:364-76. 2010..PR-Set7 interaction with PCNA through a specialized "PIP degron" domain targets it for PCNA-coupled CRL4(Cdt2)-dependent proteolysis... - Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancerGraeme Walker
Edinburgh Cancer Research Centre, and Department of Pathology, University of Edinburgh, Edinburgh, UK
Gynecol Oncol 106:461-8. 2007..To explore the predictive value of estrogen-regulated gene changes as indicators of sensitivity in ovarian cancer patients treated with the aromatase inhibitor Letrozole... - DNA methylation in multiple myeloma is weakly associated with gene transcriptionSungwon Jung
Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
PLoS ONE 7:e52626. 2012..Among the genes with methylation-expression correlations were IGF1R, DLC1, p16, and IL17RB. In conclusion, DNA methylation may directly regulate relatively few genes and suggests that additional studies .. - Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancerRachel C Jankowitz
Department of Medicine, Division of Hematology Oncology, UPMC, University of Pittsburgh Cancer Institute, 300 Halket Street, Suite 4628, Pittsburgh, PA 15213, USA
Breast Cancer Res 13:R98. 2011Breast Cancer Index (BCI) combines two independent biomarkers, HOXB13:IL17BR (H:I) and the 5-gene molecular grade index (MGI), that assess estrogen-mediated signalling and tumor grade, respectively... - The role of HIV-1 Vpr in promoting the infection of nondividing cells and in cell cycle arrestHamayun J Sharifi
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
Curr Opin HIV AIDS 7:187-94. 2012..Vpr and its HIV2/SIV paralogs Vpr and Vpx play in viral infection and pathogenesis showed that all three engage CRL4 ubiquitin ligase complexes. This association triggers ubiquitination and degradation of cellular substrates... - Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2Courtney G Havens
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 287:11410-21. 2012The E3 ubiquitin ligase Cullin-ring ligase 4-Cdt2 (CRL4(Cdt2)) is emerging as an important cell cycle regulator that targets numerous proteins for destruction in S phase and after DNA damage, including Cdt1, p21, and Set8... - HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1Jinwoo Ahn
Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Biol Chem 287:12550-8. 2012..factor of HIV-2/SIVsm viruses, which targets SAMHD1 for proteasome-dependent degradation, by reprogramming cellular CRL4(DCAF1) E3 ubiquitin ligase... - DDB2 promotes chromatin decondensation at UV-induced DNA damageMartijn S Luijsterburg
Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
J Cell Biol 197:267-81. 2012..is stimulated by the damaged DNA-binding protein 2 (DDB2), which is part of a CUL4A-RING ubiquitin ligase (CRL4) complex. In this paper, we report a new function of DDB2 in modulating chromatin structure at DNA lesions... - Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responsesChris J Corrigan
King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
J Allergy Clin Immunol 128:116-24. 2011..IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses... - CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10Manpreet Kaur
National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
Nucleic Acids Res 40:7332-46. 2012..Hence, these results establish that Cul4-DDB1-VprBP ubiquitin ligase mediates the stress-induced proteolysis of replication factor, Mcm10... - The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stabilityLing Zhang
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL USA
Cell Cycle 11:4378-84. 2012..DDB2 is required for efficient repair of CPDs in chromatin and is a component of the CRL4 (DDB2) E3 ligase that targets XPC, histones and DDB2 itself for ubiquitination... - TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21Lei Zhang
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
Proc Natl Acad Sci U S A 109:20937-42. 2012..prevents Cdt2 from binding to p21, therefore blocking ubiquitylation and proteasomal degradation of p21 mediated by CRL4(Cdt2) E3 ligase... - Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathologyBryan C Petersen
Department of Pathology, University of Michigan, Ann Arbor, USA
Nat Med 18:751-8. 2012..b>Il17rb(-/-) mice showed reduced lung pathology after chronic allergen exposure and decreased type 2 cytokine production .. - The role of PR-Set7 in replication licensing depends on Suv4-20hDavid B Beck
Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 26:2580-9. 2012..PR-Set7 is required for proper cell cycle progression and is subject to degradation by the CRL4(Cdt2) ubiquitin ligase complex as a function of the cell cycle and DNA damage... - Gene polymorphisms of interleukin-17 and interleukin-17 receptor are associated with end-stage kidney diseaseYang Gyun Kim
Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
Am J Nephrol 36:472-7. 2012..However, the genetic relationship between end-stage renal disease (ESRD) and the T-helper 17 pathway has never been studied. In this study, we hypothesized that polymorphisms of IL-17 or their receptors may be associated with ESRD... - CRL4(CDT2) targets CHK1 for PCNA-independent destructionJiwon Huh
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
Mol Cell Biol 33:213-26. 2013..CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4)... - SAMHD1: a novel antiviral factor in intrinsic immunityZhangming Chen
Department of Immunology, Anhui Medical University, Hefei, Anhui Province 230032, China
Future Microbiol 7:1117-26. 2012..However, some viruses evolve Vpx to recruit SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase in the cytoplasm for proteasome-dependent degradation, by which these viruses relieve .. - Merlin, a multi-suppressor from cell membrane to the nucleusLu Zhou
Clinical Neurobiology, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, UK
FEBS Lett 586:1403-8. 2012..In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation... - Pathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseJennifer Lee
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Graduate School of Medical Sciences of Cornell University New York, NY, USA
Front Oncol 2:21. 2012The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1-CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions... - DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transductionJae Hoon Lee
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
Plant Sci 180:352-7. 2011..binding WD40) proteins have been reported as substrate receptors for cullin-RING ubiquitin ligase 4 complexes (CRL4), a family of E3 ligases... - Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitisYuri Matsumoto
Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
Allergol Int 60:87-92. 2011..However, the molecular mechanisms that underlie SAR are only partially understood. The aim of the study was to identify novel genes related to SAR during natural exposure to pollens, by using microarray analysis... - CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase functionClaudia Kerzendorfer
Human DNA Damage Response Disorders Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
Mech Ageing Dev 132:366-73. 2011..Herein, we focus on one member of the cullin family, namely the Cullin 4-RING E3 ligases (CRL4's)... - Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trialP L Jerevall
Department of Clinical and Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linkoping University, Linkoping, SE58185, Sweden
Br J Cancer 104:1762-9. 2011A dichotomous index combining two gene expression assays, HOXB13:IL17BR (H:I) and molecular grade index (MGI), was developed to assess risk of recurrence in breast cancer patients... - Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!Andrea Scrima
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
FEBS Lett 585:2818-25. 2011..We will examine the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 focusing on shared architectural, targeting and regulatory principles... - Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylationEstrella Guarino
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Nucleic Acids Res 39:5978-90. 2011Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiquitylation, which is triggered by DNA binding of proliferating cell nuclear antigen (PCNA)... - The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesisYan Yin
Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110, USA
Dev Biol 356:51-62. 2011The Cullin-RING ubiquitin-ligase CRL4 controls cell cycle and DNA damage checkpoint response and ensures genomic integrity... - The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sexGary M Hunninghake
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
BMC Pulm Med 11:17. 2011..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known... - Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complexEtsuko Shibata
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
Mol Cell Biol 31:3136-45. 2011b>CRL4(Cdt2) is a cullin-based E3 ubiquitin ligase that promotes the ubiquitin-dependent proteolysis of various substrates implicated in the control of cell cycle and various DNA metabolic processes such as DNA replication and repair... - Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinKasia Hrecka
Department of Molecular Biology and Microbiology, Case School of Medicine, Cleveland, Ohio 44106, USA
Nature 474:658-61. 2011..Vpx relieves the inhibition of lentivirus infection in macrophages by loading SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase, leading to highly efficient proteasome-dependent degradation of the protein... - Evolution of the IL17 receptor family in chordates: a new subfamily IL17RELBaojun Wu
Laboratory of Developmental Immunology, School of Life Science, Shandong University, Jinan, China
Immunogenetics 63:835-45. 2011..IL17RA and IL17RD are found in most vertebrates, whereas the other three, IL17RB, ILR17RC, and IL17RE, underwent some loss in vertebrates during evolution... - The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancerXiao Jun Ma
AviaraDx Inc, Carlsbad, CA, USA
J Clin Oncol 24:4611-9. 2006We previously identified three genes, HOXB13, IL17BR and CHDH, and the HOXB13:IL17BR ratio index in particular, that strongly predicted clinical outcome in breast cancer patients receiving tamoxifen monotherapy... - Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorSrikripa Chandrasekaran
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7260, USA
Mol Cell Biol 31:4405-16. 2011..Two other CRL4(Cdt2) targets, the cyclin-dependent kinase (CDK) inhibitor p21 and the methyltransferase PR-Set7/Set8, are .. - Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleusTadashi Nakagawa
Department of Biochemistry and Biophysics Lineberger Comprehensive Cancer Center Program in Molecular Biology and Biotechnology University of North Carolina at Chapel Hill Chapel Hill, NC USA
Cell Cycle 10:4197-8. 2011..Comment on: Nakagawa T, et al. Mol Cell. 2011; 43:381-91... - Control of Drosophila endocycles by E2F and CRL4(CDT2)Norman Zielke
German Cancer Research Center DKFZ Zentrum für Molekulare Biologie der Universität Heidelberg Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Nature 480:123-7. 2011..in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1 (ref. 7)... - The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligaseYongming Li
Department of Biochemistry and Molecular Biology, The George Washington University Medical School, Washington, DC 20037, USA
J Biol Chem 286:41344-52. 2011..Here we show that the ablation of Cullin4-RING E3 ubiquitin ligase (CRL4) leads to the stabilization of Gcn5 in cells with depleted And-1, and Cdc10-dependent transcript 2 (Cdt2) serves as .. - A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destructionMalavika Raman
Department of Cell Biology, Harvard Medical School, Boston, MA 01230, USA
Mol Cell 44:72-84. 2011..methyltransferase SET8, are targeted for proteolysis during DNA replication and repair by the E3 ubiquitin ligase CRL4(CDT2)... - Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expressionJonathan Cooper
Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Sci Signal 4:pt6. 2011..unphosphorylated, growth-inhibiting form of Merlin accumulates in the nucleus and binds to the E3 ubiquitin ligase CRL4(DCAF1) to suppress its activity. Depletion of DCAF1 blocks the hyperproliferation caused by inactivation of Merlin... - Using Drosophila S2 cells to measure S phase-coupled protein destruction via flow cytometryJean M Davidson
Department of Biology, University of North Carolina, Chapel Hill, NC, USA
Methods Mol Biol 782:205-19. 2011..a motif called a PIP degron that mediates binding to chromatin bound PCNA at replication forks and recruits the CRL4(Cdt2) E3 ubiquitin ligase... - Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseCourtney G Havens
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 25:1568-82. 2011..Recently, an E3 ubiquitin ligase called CRL4(Cdt2) has been characterized, which couples proteolysis to DNA synthesis via an unusual mechanism that involves .. - The molecular biology and novel treatments of vestibular schwannomasBrendan Fong
Department of Neurological Surgery, University of California, Los Angeles, CA 90095 1761, USA
J Neurosurg 115:906-14. 2011..Recently, merlin was also shown to interact in the nucleus with E3 ubiquitin ligase CRL4(DCAF1)... - The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprintingEva Dumbliauskas
Institut de Biologie Moleculaire des Plantes, Centre National de la Recherche Scientifique, Unite Propre de Recherche, Conventionné avec l Université de Strasbourg, Strasbourg, France
EMBO J 30:731-43. 2011..Among putative CRL4 receptors we identified MULTICOPY SUPPRESSOR OF IRA1 (MSI1), which belongs to an evolutionary conserved protein .. - The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1Jinwoo Ahn
University of Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Biochemistry 50:1359-67. 2011The cullin4A-RING E3 ubiquitin ligase (CRL4) is a multisubunit protein complex, comprising cullin4A (CUL4), RING H2 finger protein (RBX1), and DNA damage-binding protein 1 (DDB1)... - Association of IL-17RB gene polymorphism with asthmaJi Sun Jung
Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
Chest 135:1173-80. 2009..The activation of IL-17RB amplifies allergic-type inflammatory responses by inducing Jun kinase (or JNK), p38 mitogen-activated protein kinase (or MAPK), and nuclear factor-kappaB... - Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegansSeung Hwan Kim
The Biological Laboratories, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Mol Cell 32:757-66. 2008..report that DNA damage triggers the degradation of POLH-1 and that degradation is mediated by the Cul4-Ddb1-Cdt2 (CRL4-Cdt2) pathway that has previously been shown to degrade the replication factor Cdt1 during S phase... - The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensingYoungjo Kim
Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 USA
Genes Dev 22:2507-19. 2008..A vertebrate CUL4 CRL ubiquitin ligase (CRL4) complex containing Cdt2 as the substrate recognition subunit promotes proper DNA replication, in part, by .. - Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistanceMatthew P Goetz
Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Cancer Res 14:5864-8. 2008..P450 2D6 (CYP2D6) and the gene expression ratio of the homeobox 13 (HOXB13) to interleukin-17B receptor (IL17BR) are associated with tamoxifen resistance... - Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancerBenjamin A T Rodriguez
Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 29:1459-65. 2008Several studies have reported that a high expression ratio of HOXB13 to IL17BR predicts tumor recurrence in node-negative, estrogen receptor (ER) alpha-positive breast cancer patients treated with tamoxifen... - A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancerXiao Jun Ma
AviaraDx, Inc, San Diego, California, USA
Clin Cancer Res 14:2601-8. 2008..as follows: (a) to develop a simple gene expression index for tumor grade (molecular grade index or MGI), and (b) to determine whether MGI and our previously described HOXB13:IL17BR index together provide improved prognostic information. - Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifenMarleen Kok
Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
Breast Cancer Res Treat 113:275-83. 2009..For the first time, we compared these response profiles in an independent cohort of (neo)adjuvant systemic treatment naïve breast cancer patients treated with first-line tamoxifen for metastatic disease... - The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancerZuncai Wang
Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Cancer Res 13:6327-34. 2007We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor (ER)-positive breast cancer patients receiving tamoxifen monotherapy... - HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective studyMaurice P H M Jansen
Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
J Clin Oncol 25:662-8. 2007A HOXB13-to-IL17BR expression ratio was previously identified to predict clinical outcome of breast cancer patients treated with adjuvant tamoxifen... - A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifenMatthew P Goetz
Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Clin Cancer Res 12:2080-7. 2006..In the adjuvant treatment of estrogen receptor (ER)-positive breast cancer, additional markers are needed to identify women at high risk for recurrence... - Genomic testing for sensitivity of breast cancer to hormonal therapyW Fraser Symmans
Clin Cancer Res 12:1954-5. 2006 - IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblastsSeverine Letuve
Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Quebec, Canada
J Allergy Clin Immunol 117:590-6. 2006..IL-17E proinflammatory activity has been proposed to involve induction of cytokine and chemokine production. Recruitment of inflammatory cells may be mediated by tissue-resident cells... - TNF-alpha and IFN-gamma inversely modulate expression of the IL-17E receptor in airway smooth muscle cellsStéphane Lajoie-Kadoch
Meakins Christie Laboratories, McGill University, 3626 St Urbain Street, Montreal, Quebec, Canada H2X 2P2
Am J Physiol Lung Cell Mol Physiol 290:L1238-46. 2006..Our results suggest a potential proremodeling effect of IL-17E on airway smooth muscle cells through the induction of ECM and that its receptor is upregulated by proinflammatory conditions... - Limits of predictive models using microarray data for breast cancer clinical treatment outcomeJames F Reid
Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
J Natl Cancer Inst 97:927-30. 2005..We measured expression of the genes HOXB13 and IL17BR with real time-quantitative polymerase chain reaction and assessed the association between their expression and .. - Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody productionMee Rhan Kim
Departments of Functional Genomics, Pathology, Inflammation, Clinical Immunology, and Protein Science, Amgen Inc, Thousand Oaks, California 91302, USA
Blood 100:2330-40. 2002..In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated... - IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1J Lee
Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
J Biol Chem 276:1660-4. 2001..IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor .. - An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligasesMichael Hans Olma
Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, 8093 Zurich, Switzerland
J Cell Sci 122:1035-44. 2009..The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage... - Genomic predictors of outcome and treatment response in breast cancerLara Dunn
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mol Diagn Ther 13:73-90. 2009..MammaPrint (Agendia BV), and the HOXB13/IL17BR (H/I) ratio; (Theros H/ISM; bioTheranostics)... - Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2Courtney G Havens
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 35:93-104. 2009Substrates of the E3 ubiquitin ligase CRL4(Cdt2), including Cdt1 and p21, contain a PCNA-binding motif called a PIP box. Upon binding of the PIP box to PCNA on chromatin, CRL4(Cdt2) is recruited and the substrate is ubiquitylated... - A new regulator of the cell cycle: the PR-Set7 histone methyltransferaseShumin Wu
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Cell Cycle 10:68-72. 2011..regulated during different cell cycle phases by distinct enzymes including cdk1/cyclinB, Cdc14, SCF(Skp2), CRL4(cdt2) and APC(cdh1)... - Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysisMasato Michishita
Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo 678 1297, Japan
Genes Cells 16:12-22. 2011PCNA links Cdt1 and p21 for proteolysis by Cul4-DDB1-Cdt2 (CRL4(Cdt2) ) in the S phase and after DNA damage in mammalian cells. However, other PCNA-interacting proteins, such as ligase I, are not targets of CRL4(Cdt2) ... - Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1)Wei Li
Sloan Kettering Institute for Cancer Research, New York, NY, USA
Cell Cycle 9:4433-6. 2010..have recently observed that Merlin translocates into the nucleus and binds to and inhibits the E3 ubiquitin ligase CRL4 (DCAF1) ... - SETting the clock for histone H4 monomethylationJennifer Lee
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
Mol Cell 40:345-6. 2010..2010), Abbas et al. (2010), and Centore et al. (2010) determined that the H4K20 histone methyltransferase PR-Set7/Set8 is posttranslationally regulated by the PCNA-dependent CRL4(Cdt2) ubiquitin ligase. - CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phaseRichard C Centore
Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
Mol Cell 40:22-33. 2010..we show that Set8 is targeted for proteolysis in S phase and in response to DNA damage by the E3 ubiquitin ligase, CRL4(Cdt2)... - CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationTarek Abbas
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
Mol Cell 40:9-21. 2010..We identify CRL4(Cdt2) as the principal E3 ubiquitin ligase responsible for Set8 proteolytic degradation in the S phase of the cell .. - Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cellsTakashi Ishii
Graduate School of Life Science, University of Hyogo, Kouto 3 2 1, Kamigori, Ako gun, Hyogo 678 1297, Japan
J Biol Chem 285:41993-2000. 2010The licensing factor Cdt1 is degraded by CRL4(Cdt2) ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage is induced in G(1) phase... - HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradationJinwoo Ahn
Department of Structural Biology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania 15260, USA
J Biol Chem 285:37333-41. 2010..host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin ligase assembly (CRL4(DCAF1))... - Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phaseHyun O Lee
Curriculum in Genetics and Molecular Biology, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
Mol Biol Cell 21:3639-53. 2010DNA synthesis-coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4(Cdt2) E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase... - CRL4s: the CUL4-RING E3 ubiquitin ligasesSarah Jackson
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
Trends Biochem Sci 34:562-70. 2009..Many CRL4 complexes are involved in chromatin regulation and are frequently hijacked by different viruses. - PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?Gaston Soria
Fundación Instituto Leloir CONICET, Universidad de Buenos Aires, Argentina
DNA Repair (Amst) 9:358-64. 2010..Moreover, conclusive reports identified the E3-ligase CRL4(CDT2) (CUL4-DDB1-CDT2) as the enzymatic complex that promotes p21 proteolysis when treatments such as UV .. - CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesisKenta Terai
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
Mol Cell 37:143-9. 2010..We show that the CRL4(Cdt2) E3 ubiquitin ligase complex promotes PCNA monoubiqutination in proliferating cells in the absence of external .. - Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleusWei Li
Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cell 140:477-90. 2010..show that the closed, growth-inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4(DCAF1), and suppresses its activity. Depletion of DCAF1 blocks the promitogenic effect of inactivation of Merlin... - The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNADong Hyun Kim
Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
Mol Cell Biol 30:4120-33. 2010..In this study, we show that the predominant E3 for Xic1 in the egg is the Cul4-DDB1-XCdt2 (Xenopus Cdt2) (CRL4(Cdt2)) ubiquitin ligase... - Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytesMarc Le Vee
EA 4427 Signalisation et Réponse aux Agents Infectieux et Chimiques, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, Rennes, France
Toxicol In Vitro 24:1775-81. 2010..e. CYP1A1, CYP1A2, CYP1B1, ALDH3A1, IL17RB, FER1L3 and SLC7A5, when compared to TCDD-treated counterparts transfected with non-targeting small-interfering .. - Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancerPiiha Lotta Jerevall
Department of Clinical and Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
Breast Cancer Res 12:R53. 2010The HOXB13:IL17BR index has been identified to predict clinical outcome in the setting of adjuvant tamoxifen monotherapy of breast cancer... - Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transductionR Schwandner
Tularik Incorporated, South San Francisco, California 94080, USA
J Exp Med 191:1233-40. 2000..Together, these results indicate that TRAF6, but not TRAF2, is a crucial component in the IL-17 signaling pathway leading to proinflammatory responses... - A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activityY Shi
Departments of Molecular Biology, Protein Development, Strategic Drug Development, and Cell Biology, Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
J Biol Chem 275:19167-76. 2000..Together these results suggest that IL-17B may be a novel proinflammatory cytokine acting on a restricted set of target cell types. They also demonstrate the strength of genomic approaches in the unraveling of novel biological pathways...
Research Grants
- Structural studies of cullin-based ubiquitin ligasesNing Zheng; Fiscal Year: 2010..will be used to investigate how the substrate receptor subunits (DCAFs) of a newly identified family of CLRs, the CRL4 E3 complexes, are recruited to the ubiquitin ligase machinery...
- A Novel Breast Cancer BiomarkerDennis C Sgroi; Fiscal Year: 2010..We have developed a novel real-time PCR assay, HOXB13:IL17BR-MGI, which is a robust, independent prognostic and predictive biomarker of both tamoxifen and aromatase inhibitor ..
- A Novel Breast Cancer BiomarkerDennis Sgroi; Fiscal Year: 2009..This biomarker, consisting of a ratio of two genes, the homeobox gene HOXB13 and the interleukin 17B receptor gene, outperforms all existing biomarkers...
- The Cullin-ROC Family of E3 Ubiquitin LigasesYue Xiong; Fiscal Year: 2010..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
- The Cullin-ROC Family of E3 Ubiquitin LigasesYue Xiong; Fiscal Year: 2010..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
- Tamoxifen biotransformation pathway pharmacogenomicsMatthew Goetz; Fiscal Year: 2009....
- Tamoxifen biotransformation pathway pharmacogenomicsMATTHEW PHILIP GOETZ; Fiscal Year: 2010....