IL17RB

Summary

Gene Symbol: IL17RB
Description: interleukin 17 receptor B
Alias: CRL4, EVI27, IL17BR, IL17RH1, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17RB, IL-17Rh1, cytokine receptor CRL4, cytokine receptor-like 4, interleukin 17 receptor homolog 1, interleukin 17B receptor, interleukin-17 receptor B, interleukin-17B receptor
Species: human

Top Publications

  1. doi Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation
    H Wang
    The Unit for Clinical Systems Biology, Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Sahlgrenska Academy, University of Gothenburg, and The Pediatric Allergy Unit, The Queen Silvia Children s Hospital, Gothenburg, Sweden
    Clin Exp Allergy 40:1194-202. 2010
  2. ncbi Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome
    Piiha Lotta Jerevall
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, Linkoping, Sweden
    Breast Cancer Res Treat 107:225-34. 2008
  3. ncbi Evi27 encodes a novel membrane protein with homology to the IL17 receptor
    E Tian
    Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Oncogene 19:2098-109. 2000
  4. pmc PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
  5. pmc Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
    Hisanobu Oda
    Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 40:364-76. 2010
  6. ncbi Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer
    Graeme Walker
    Edinburgh Cancer Research Centre, and Department of Pathology, University of Edinburgh, Edinburgh, UK
    Gynecol Oncol 106:461-8. 2007
  7. pmc The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells
    Agathe Bacquin
    Universite Paris Sud, CNRS UMR8200 Unit of Genetic Stability and Oncogenesis, Institut de Cancerologie Gustave Roussy, Villejuif, France
    Nucleic Acids Res 41:6501-13. 2013
  8. doi Variation of Two Primate Lineage-Specific Residues in Human SAMHD1 Confers Resistance to N Terminus-Targeted SIV Vpx Proteins
    Wei Wei
    School of Life Science, Tianjin University, Tianjin, China
    J Virol 88:583-91. 2014
  9. ncbi A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
    Xiao Jun Ma
    Arcturus Bioscience, Inc, 2715 Loker Avenue West, Carlsbad, CA 92008, USA
    Cancer Cell 5:607-16. 2004
  10. doi Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker
    Dennis C Sgroi
    Department of Pathology, Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Natl Cancer Inst 105:1036-42. 2013

Research Grants

  1. Structural studies of cullin-based ubiquitin ligases
    Ning Zheng; Fiscal Year: 2010
  2. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2010
  3. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2010
  4. Tamoxifen biotransformation pathway pharmacogenomics
    MATTHEW PHILIP GOETZ; Fiscal Year: 2010
  5. Tamoxifen biotransformation pathway pharmacogenomics
    Matthew Goetz; Fiscal Year: 2009
  6. A Novel Breast Cancer Biomarker
    Dennis C Sgroi; Fiscal Year: 2010
  7. A Novel Breast Cancer Biomarker
    Dennis Sgroi; Fiscal Year: 2009

Scientific Experts

  • Piiha Lotta Jerevall
  • MATTHEW PHILIP GOETZ
  • Tarek Abbas
  • Dennis Sgroi
  • Julia Kzhyshkowska
  • Rachel C Jankowitz
  • Jean M Davidson
  • H Wang
  • Vanesa Gottifredi
  • Jinwoo Ahn
  • G M Hunninghake
  • Maurice P H M Jansen
  • James F Reid
  • Yue Xiong
  • Ning Zheng
  • Courtney G Havens
  • Xiao Jun Ma
  • Pengbo Zhou
  • Johannes C Walter
  • Wei Li
  • Kenta Terai
  • Lu Zhou
  • Jennifer Lee
  • Etsuko Shibata
  • Anindya Dutta
  • Estrella Guarino
  • David B Beck
  • C Oliver Hanemann
  • Hisanobu Oda
  • Richard C Centore
  • Jonathan Cooper
  • Takashi Ishii
  • Filippo G Giancotti
  • Severine Letuve
  • Wilson Wang
  • Wei Wei
  • Zuncai Wang
  • Stéphane Lajoie-Kadoch
  • Agathe Bacquin
  • Jiwon Huh
  • Wei wei Pan
  • Mario Rossi
  • Maria Delucia
  • Lei Zhang
  • Martijn S Luijsterburg
  • Ling Zhang
  • Manpreet Kaur
  • Laurence Florens
  • Yang Gyun Kim
  • Sungwon Jung
  • Zhangming Chen
  • Hamayun J Sharifi
  • Michael P Washburn
  • Bryan C Petersen
  • Stephen E Kearsey
  • Eva Dumbliauskas
  • Baojun Wu
  • Andrea Scrima
  • Danny Reinberg
  • Yuri Matsumoto
  • Chris J Corrigan
  • Claudia Kerzendorfer
  • Srikripa Chandrasekaran
  • Lee Zou
  • Norman Zielke
  • Jae Hoon Lee
  • Yongming Li
  • Brendan Fong
  • Malavika Raman
  • Yan Yin
  • Tadashi Nakagawa
  • Kasia Hrecka
  • Masato Michishita
  • Shumin Wu
  • Yasushi Shiomi
  • Gaia Schiavon
  • Stephen B Long
  • Hideo Nishitani
  • Angela Pepe-Caprio
  • Hediye Erdjument-Bromage
  • Liru You
  • Paul Tempst
  • Marco Giovannini
  • Robert J Duronio
  • Ryohei Ishii
  • Marc Le Vee
  • Hyun O Lee
  • Gaston Soria
  • Dong Hyun Kim
  • Sarah Jackson

Detail Information

Publications91

  1. doi Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation
    H Wang
    The Unit for Clinical Systems Biology, Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Sahlgrenska Academy, University of Gothenburg, and The Pediatric Allergy Unit, The Queen Silvia Children s Hospital, Gothenburg, Sweden
    Clin Exp Allergy 40:1194-202. 2010
    ..Allergen-challenged peripheral blood mononuclear cells (PBMCs) provide a human in vitro model of how antigen-presenting cells, CD4+ T cells and effector cells such as basophils interact in allergic inflammation...
  2. ncbi Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome
    Piiha Lotta Jerevall
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, Linkoping, Sweden
    Breast Cancer Res Treat 107:225-34. 2008
    The two-gene expression ratio HOXB13:IL17BR has been proposed to predict the outcome of tamoxifen-treated breast cancer patients. We intended to examine whether this ratio can predict the benefit of 5 years vs...
  3. ncbi Evi27 encodes a novel membrane protein with homology to the IL17 receptor
    E Tian
    Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Oncogene 19:2098-109. 2000
    b>Evi27 is a common site of retroviral integration in BXH2 murine myeloid leukemias...
  4. pmc PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
    ..Antigen (PCNA) promotes the DNA damage-induced degradation of the replication initiation factor Cdt1 via the CRL4(Cdt2) E3 ubiquitin ligase complex...
  5. pmc Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
    Hisanobu Oda
    Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 40:364-76. 2010
    ..response, PR-Set7 interaction with PCNA through a specialized "PIP degron" domain targets it for PCNA-coupled CRL4(Cdt2)-dependent proteolysis...
  6. ncbi Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer
    Graeme Walker
    Edinburgh Cancer Research Centre, and Department of Pathology, University of Edinburgh, Edinburgh, UK
    Gynecol Oncol 106:461-8. 2007
    ..To explore the predictive value of estrogen-regulated gene changes as indicators of sensitivity in ovarian cancer patients treated with the aromatase inhibitor Letrozole...
  7. pmc The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells
    Agathe Bacquin
    Universite Paris Sud, CNRS UMR8200 Unit of Genetic Stability and Oncogenesis, Institut de Cancerologie Gustave Roussy, Villejuif, France
    Nucleic Acids Res 41:6501-13. 2013
    ..Intriguingly, after its re-localization, FBH1 is targeted for degradation by the Cullin-ring ligase 4-Cdt2 (CRL4(Cdt2))-PCNA pathway via a PCNA-interacting peptide (PIP) degron...
  8. doi Variation of Two Primate Lineage-Specific Residues in Human SAMHD1 Confers Resistance to N Terminus-Targeted SIV Vpx Proteins
    Wei Wei
    School of Life Science, Tianjin University, Tianjin, China
    J Virol 88:583-91. 2014
    ..Vpx proteins recruit the DCAF1-CRL4 E3 ubiquitin ligase to trigger species-specific SAMHD1 degradation...
  9. ncbi A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
    Xiao Jun Ma
    Arcturus Bioscience, Inc, 2715 Loker Avenue West, Carlsbad, CA 92008, USA
    Cancer Cell 5:607-16. 2004
    ..An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers...
  10. doi Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker
    Dennis C Sgroi
    Department of Pathology, Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Natl Cancer Inst 105:1036-42. 2013
    ..The HOXB13/IL17BR (H/I) biomarker predicts recurrence risk in ER-positive, lymph node-negative breast cancer patients...
  11. pmc Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer
    Wei wei Pan
    From the Life Sciences Institute, Zhejiang University, Hangzhou 310058
    J Biol Chem 288:29680-91. 2013
    ..We show here that CRL4 components are highly expressed in human epithelial ovarian cancer tissues...
  12. pmc Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage
    Kenta Terai
    From the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908
    J Biol Chem 288:30509-14. 2013
    ..b>CRL4(Cdt2) is an E3 ligase that ubiquitinates and degrades p12 after UV treatment...
  13. pmc HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation
    Maria Delucia
    Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 288:19116-26. 2013
    ..restriction via a virion-associated virulence accessory factor, Vpx (Vpr in some SIVs), which loads SAMHD1 onto CRL4-DCAF1 E3 ubiquitin ligase for polyubiquitination, programming it for proteasome-dependent degradation...
  14. pmc Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase
    Mario Rossi
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, NY 10016, USA
    Mol Cell 49:1159-66. 2013
    ..DCAF proteins are the substrate binding subunits of the Skp1-Cul1-F-box protein (SCF) and Cul4-RING protein ligase (CRL4) ubiquitin ligase complexes, respectively...
  15. pmc Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology
    Bryan C Petersen
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Nat Med 18:751-8. 2012
    ..b>Il17rb(-/-) mice showed reduced lung pathology after chronic allergen exposure and decreased type 2 cytokine production ..
  16. pmc DDB2 promotes chromatin decondensation at UV-induced DNA damage
    Martijn S Luijsterburg
    Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Cell Biol 197:267-81. 2012
    ..is stimulated by the damaged DNA-binding protein 2 (DDB2), which is part of a CUL4A-RING ubiquitin ligase (CRL4) complex. In this paper, we report a new function of DDB2 in modulating chromatin structure at DNA lesions...
  17. pmc HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1
    Jinwoo Ahn
    Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 287:12550-8. 2012
    ..factor of HIV-2/SIVsm viruses, which targets SAMHD1 for proteasome-dependent degradation, by reprogramming cellular CRL4(DCAF1) E3 ubiquitin ligase...
  18. pmc Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2
    Courtney G Havens
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 287:11410-21. 2012
    The E3 ubiquitin ligase Cullin-ring ligase 4-Cdt2 (CRL4(Cdt2)) is emerging as an important cell cycle regulator that targets numerous proteins for destruction in S phase and after DNA damage, including Cdt1, p21, and Set8...
  19. pmc The role of HIV-1 Vpr in promoting the infection of nondividing cells and in cell cycle arrest
    Hamayun J Sharifi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Curr Opin HIV AIDS 7:187-94. 2012
    ..Vpr and its HIV2/SIV paralogs Vpr and Vpx play in viral infection and pathogenesis showed that all three engage CRL4 ubiquitin ligase complexes. This association triggers ubiquitination and degradation of cellular substrates...
  20. pmc Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer
    Rachel C Jankowitz
    Department of Medicine, Division of Hematology Oncology, UPMC, University of Pittsburgh Cancer Institute, 300 Halket Street, Suite 4628, Pittsburgh, PA 15213, USA
    Breast Cancer Res 13:R98. 2011
    Breast Cancer Index (BCI) combines two independent biomarkers, HOXB13:IL17BR (H:I) and the 5-gene molecular grade index (MGI), that assess estrogen-mediated signalling and tumor grade, respectively...
  21. doi Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses
    Chris J Corrigan
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    J Allergy Clin Immunol 128:116-24. 2011
    ..IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses...
  22. pmc CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10
    Manpreet Kaur
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Nucleic Acids Res 40:7332-46. 2012
    ..Hence, these results establish that Cul4-DDB1-VprBP ubiquitin ligase mediates the stress-induced proteolysis of replication factor, Mcm10...
  23. doi Merlin, a multi-suppressor from cell membrane to the nucleus
    Lu Zhou
    Clinical Neurobiology, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, UK
    FEBS Lett 586:1403-8. 2012
    ..In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation...
  24. pmc DNA methylation in multiple myeloma is weakly associated with gene transcription
    Sungwon Jung
    Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
    PLoS ONE 7:e52626. 2012
    ..Among the genes with methylation-expression correlations were IGF1R, DLC1, p16, and IL17RB. In conclusion, DNA methylation may directly regulate relatively few genes and suggests that additional studies ..
  25. pmc The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability
    Ling Zhang
    Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL USA
    Cell Cycle 11:4378-84. 2012
    ..DDB2 is required for efficient repair of CPDs in chromatin and is a component of the CRL4 (DDB2) E3 ligase that targets XPC, histones and DDB2 itself for ubiquitination...
  26. pmc TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21
    Lei Zhang
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Proc Natl Acad Sci U S A 109:20937-42. 2012
    ..prevents Cdt2 from binding to p21, therefore blocking ubiquitylation and proteasomal degradation of p21 mediated by CRL4(Cdt2) E3 ligase...
  27. doi Gene polymorphisms of interleukin-17 and interleukin-17 receptor are associated with end-stage kidney disease
    Yang Gyun Kim
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
    Am J Nephrol 36:472-7. 2012
    ..However, the genetic relationship between end-stage renal disease (ESRD) and the T-helper 17 pathway has never been studied. In this study, we hypothesized that polymorphisms of IL-17 or their receptors may be associated with ESRD...
  28. pmc The role of PR-Set7 in replication licensing depends on Suv4-20h
    David B Beck
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Genes Dev 26:2580-9. 2012
    ..PR-Set7 is required for proper cell cycle progression and is subject to degradation by the CRL4(Cdt2) ubiquitin ligase complex as a function of the cell cycle and DNA damage...
  29. pmc Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
    Jennifer Lee
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Graduate School of Medical Sciences of Cornell University New York, NY, USA
    Front Oncol 2:21. 2012
    The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1-CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions...
  30. pmc CRL4(CDT2) targets CHK1 for PCNA-independent destruction
    Jiwon Huh
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 33:213-26. 2013
    ..CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4)...
  31. doi SAMHD1: a novel antiviral factor in intrinsic immunity
    Zhangming Chen
    Department of Immunology, Anhui Medical University, Hefei, Anhui Province 230032, China
    Future Microbiol 7:1117-26. 2012
    ..However, some viruses evolve Vpx to recruit SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase in the cytoplasm for proteasome-dependent degradation, by which these viruses relieve ..
  32. doi Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
    Andrea Scrima
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FEBS Lett 585:2818-25. 2011
    ..We will examine the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 focusing on shared architectural, targeting and regulatory principles...
  33. pmc Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
    Kasia Hrecka
    Department of Molecular Biology and Microbiology, Case School of Medicine, Cleveland, Ohio 44106, USA
    Nature 474:658-61. 2011
    ..Vpx relieves the inhibition of lentivirus infection in macrophages by loading SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase, leading to highly efficient proteasome-dependent degradation of the protein...
  34. pmc Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
    Etsuko Shibata
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 31:3136-45. 2011
    b>CRL4(Cdt2) is a cullin-based E3 ubiquitin ligase that promotes the ubiquitin-dependent proteolysis of various substrates implicated in the control of cell cycle and various DNA metabolic processes such as DNA replication and repair...
  35. pmc The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis
    Yan Yin
    Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 356:51-62. 2011
    The Cullin-RING ubiquitin-ligase CRL4 controls cell cycle and DNA damage checkpoint response and ensures genomic integrity...
  36. pmc Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation
    Estrella Guarino
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nucleic Acids Res 39:5978-90. 2011
    Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiquitylation, which is triggered by DNA binding of proliferating cell nuclear antigen (PCNA)...
  37. pmc Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial
    P L Jerevall
    Department of Clinical and Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linkoping University, Linkoping, SE58185, Sweden
    Br J Cancer 104:1762-9. 2011
    A dichotomous index combining two gene expression assays, HOXB13:IL17BR (H:I) and molecular grade index (MGI), was developed to assess risk of recurrence in breast cancer patients...
  38. doi Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL
    Baojun Wu
    Laboratory of Developmental Immunology, School of Life Science, Shandong University, Jinan, China
    Immunogenetics 63:835-45. 2011
    ..IL17RA and IL17RD are found in most vertebrates, whereas the other three, IL17RB, ILR17RC, and IL17RE, underwent some loss in vertebrates during evolution...
  39. doi The molecular biology and novel treatments of vestibular schwannomas
    Brendan Fong
    Department of Neurological Surgery, University of California, Los Angeles, CA 90095 1761, USA
    J Neurosurg 115:906-14. 2011
    ..Recently, merlin was also shown to interact in the nucleus with E3 ubiquitin ligase CRL4(DCAF1)...
  40. pmc Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase
    Courtney G Havens
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:1568-82. 2011
    ..Recently, an E3 ubiquitin ligase called CRL4(Cdt2) has been characterized, which couples proteolysis to DNA synthesis via an unusual mechanism that involves ..
  41. ncbi The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer
    Xiao Jun Ma
    AviaraDx Inc, Carlsbad, CA, USA
    J Clin Oncol 24:4611-9. 2006
    We previously identified three genes, HOXB13, IL17BR and CHDH, and the HOXB13:IL17BR ratio index in particular, that strongly predicted clinical outcome in breast cancer patients receiving tamoxifen monotherapy...
  42. ncbi Chromatin regulation by CRL4 E3 ubiquitin ligases: CUL4B targets WDR5 ubiquitylation in the nucleus
    Tadashi Nakagawa
    Department of Biochemistry and Biophysics Lineberger Comprehensive Cancer Center Program in Molecular Biology and Biotechnology University of North Carolina at Chapel Hill Chapel Hill, NC USA
    Cell Cycle 10:4197-8. 2011
    ..Comment on: Nakagawa T, et al. Mol Cell. 2011; 43:381-91...
  43. pmc Control of Drosophila endocycles by E2F and CRL4(CDT2)
    Norman Zielke
    German Cancer Research Center DKFZ Zentrum für Molekulare Biologie der Universität Heidelberg Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Nature 480:123-7. 2011
    ..in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1 (ref. 7)...
  44. pmc The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase
    Yongming Li
    Department of Biochemistry and Molecular Biology, The George Washington University Medical School, Washington, DC 20037, USA
    J Biol Chem 286:41344-52. 2011
    ..Here we show that the ablation of Cullin4-RING E3 ubiquitin ligase (CRL4) leads to the stabilization of Gcn5 in cells with depleted And-1, and Cdc10-dependent transcript 2 (Cdt2) serves as ..
  45. pmc A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction
    Malavika Raman
    Department of Cell Biology, Harvard Medical School, Boston, MA 01230, USA
    Mol Cell 44:72-84. 2011
    ..methyltransferase SET8, are targeted for proteolysis during DNA replication and repair by the E3 ubiquitin ligase CRL4(CDT2)...
  46. pmc Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor
    Srikripa Chandrasekaran
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7260, USA
    Mol Cell Biol 31:4405-16. 2011
    ..Two other CRL4(Cdt2) targets, the cyclin-dependent kinase (CDK) inhibitor p21 and the methyltransferase PR-Set7/Set8, are ..
  47. doi Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression
    Jonathan Cooper
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Sci Signal 4:pt6. 2011
    ..unphosphorylated, growth-inhibiting form of Merlin accumulates in the nucleus and binds to the E3 ubiquitin ligase CRL4(DCAF1) to suppress its activity. Depletion of DCAF1 blocks the hyperproliferation caused by inactivation of Merlin...
  48. doi Using Drosophila S2 cells to measure S phase-coupled protein destruction via flow cytometry
    Jean M Davidson
    Department of Biology, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 782:205-19. 2011
    ..a motif called a PIP degron that mediates binding to chromatin bound PCNA at replication forks and recruits the CRL4(Cdt2) E3 ubiquitin ligase...
  49. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
    ..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known...
  50. doi DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transduction
    Jae Hoon Lee
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Plant Sci 180:352-7. 2011
    ..binding WD40) proteins have been reported as substrate receptors for cullin-RING ubiquitin ligase 4 complexes (CRL4), a family of E3 ligases...
  51. pmc Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction
    R Schwandner
    Tularik Incorporated, South San Francisco, California 94080, USA
    J Exp Med 191:1233-40. 2000
    ..Together, these results indicate that TRAF6, but not TRAF2, is a crucial component in the IL-17 signaling pathway leading to proinflammatory responses...
  52. doi A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer
    Xiao Jun Ma
    AviaraDx, Inc, San Diego, California, USA
    Clin Cancer Res 14:2601-8. 2008
    ..as follows: (a) to develop a simple gene expression index for tumor grade (molecular grade index or MGI), and (b) to determine whether MGI and our previously described HOXB13:IL17BR index together provide improved prognostic information.
  53. pmc Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
    Benjamin A T Rodriguez
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 29:1459-65. 2008
    Several studies have reported that a high expression ratio of HOXB13 to IL17BR predicts tumor recurrence in node-negative, estrogen receptor (ER) alpha-positive breast cancer patients treated with tamoxifen...
  54. pmc Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 14:5864-8. 2008
    ..P450 2D6 (CYP2D6) and the gene expression ratio of the homeobox 13 (HOXB13) to interleukin-17B receptor (IL17BR) are associated with tamoxifen resistance...
  55. pmc The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
    Youngjo Kim
    Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 USA
    Genes Dev 22:2507-19. 2008
    ..A vertebrate CUL4 CRL ubiquitin ligase (CRL4) complex containing Cdt2 as the substrate recognition subunit promotes proper DNA replication, in part, by ..
  56. pmc Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans
    Seung Hwan Kim
    The Biological Laboratories, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 32:757-66. 2008
    ..report that DNA damage triggers the degradation of POLH-1 and that degradation is mediated by the Cul4-Ddb1-Cdt2 (CRL4-Cdt2) pathway that has previously been shown to degrade the replication factor Cdt1 during S phase...
  57. doi Association of IL-17RB gene polymorphism with asthma
    Ji Sun Jung
    Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
    Chest 135:1173-80. 2009
    ..The activation of IL-17RB amplifies allergic-type inflammatory responses by inducing Jun kinase (or JNK), p38 mitogen-activated protein kinase (or MAPK), and nuclear factor-kappaB...
  58. pmc An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases
    Michael Hans Olma
    Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, 8093 Zurich, Switzerland
    J Cell Sci 122:1035-44. 2009
    ..The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage...
  59. doi Genomic predictors of outcome and treatment response in breast cancer
    Lara Dunn
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Diagn Ther 13:73-90. 2009
    ..MammaPrint (Agendia BV), and the HOXB13/IL17BR (H/I) ratio; (Theros H/ISM; bioTheranostics)...
  60. doi Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen
    Marleen Kok
    Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Breast Cancer Res Treat 113:275-83. 2009
    ..For the first time, we compared these response profiles in an independent cohort of (neo)adjuvant systemic treatment naïve breast cancer patients treated with first-line tamoxifen for metastatic disease...
  61. ncbi The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer
    Zuncai Wang
    Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 13:6327-34. 2007
    We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor (ER)-positive breast cancer patients receiving tamoxifen monotherapy...
  62. ncbi IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
    J Lee
    Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
    J Biol Chem 276:1660-4. 2001
    ..IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor ..
  63. ncbi Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production
    Mee Rhan Kim
    Departments of Functional Genomics, Pathology, Inflammation, Clinical Immunology, and Protein Science, Amgen Inc, Thousand Oaks, California 91302, USA
    Blood 100:2330-40. 2002
    ..In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated...
  64. ncbi Limits of predictive models using microarray data for breast cancer clinical treatment outcome
    James F Reid
    Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Natl Cancer Inst 97:927-30. 2005
    ..We measured expression of the genes HOXB13 and IL17BR with real time-quantitative polymerase chain reaction and assessed the association between their expression and ..
  65. ncbi TNF-alpha and IFN-gamma inversely modulate expression of the IL-17E receptor in airway smooth muscle cells
    Stéphane Lajoie-Kadoch
    Meakins Christie Laboratories, McGill University, 3626 St Urbain Street, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 290:L1238-46. 2006
    ..Our results suggest a potential proremodeling effect of IL-17E on airway smooth muscle cells through the induction of ECM and that its receptor is upregulated by proinflammatory conditions...
  66. ncbi IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts
    Severine Letuve
    Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 117:590-6. 2006
    ..IL-17E proinflammatory activity has been proposed to involve induction of cytokine and chemokine production. Recruitment of inflammatory cells may be mediated by tissue-resident cells...
  67. ncbi Genomic testing for sensitivity of breast cancer to hormonal therapy
    W Fraser Symmans
    Clin Cancer Res 12:1954-5. 2006
  68. ncbi A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 12:2080-7. 2006
    ..In the adjuvant treatment of estrogen receptor (ER)-positive breast cancer, additional markers are needed to identify women at high risk for recurrence...
  69. ncbi HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study
    Maurice P H M Jansen
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 25:662-8. 2007
    A HOXB13-to-IL17BR expression ratio was previously identified to predict clinical outcome of breast cancer patients treated with adjuvant tamoxifen...
  70. pmc Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2
    Courtney G Havens
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 35:93-104. 2009
    Substrates of the E3 ubiquitin ligase CRL4(Cdt2), including Cdt1 and p21, contain a PCNA-binding motif called a PIP box. Upon binding of the PIP box to PCNA on chromatin, CRL4(Cdt2) is recruited and the substrate is ubiquitylated...
  71. pmc CRL4s: the CUL4-RING E3 ubiquitin ligases
    Sarah Jackson
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Trends Biochem Sci 34:562-70. 2009
    ..Many CRL4 complexes are involved in chromatin regulation and are frequently hijacked by different viruses.
  72. pmc CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
    Richard C Centore
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 40:22-33. 2010
    ..we show that Set8 is targeted for proteolysis in S phase and in response to DNA damage by the E3 ubiquitin ligase, CRL4(Cdt2)...
  73. pmc SETting the clock for histone H4 monomethylation
    Jennifer Lee
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Cell 40:345-6. 2010
    ..2010), Abbas et al. (2010), and Centore et al. (2010) determined that the H4K20 histone methyltransferase PR-Set7/Set8 is posttranslationally regulated by the PCNA-dependent CRL4(Cdt2) ubiquitin ligase.
  74. pmc Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1)
    Wei Li
    Sloan Kettering Institute for Cancer Research, New York, NY, USA
    Cell Cycle 9:4433-6. 2010
    ..have recently observed that Merlin translocates into the nucleus and binds to and inhibits the E3 ubiquitin ligase CRL4 (DCAF1) ...
  75. doi Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis
    Masato Michishita
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo 678 1297, Japan
    Genes Cells 16:12-22. 2011
    PCNA links Cdt1 and p21 for proteolysis by Cul4-DDB1-Cdt2 (CRL4(Cdt2) ) in the S phase and after DNA damage in mammalian cells. However, other PCNA-interacting proteins, such as ligase I, are not targets of CRL4(Cdt2) ...
  76. pmc A new regulator of the cell cycle: the PR-Set7 histone methyltransferase
    Shumin Wu
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Cycle 10:68-72. 2011
    ..regulated during different cell cycle phases by distinct enzymes including cdk1/cyclinB, Cdc14, SCF(Skp2), CRL4(cdt2) and APC(cdh1)...
  77. pmc The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1
    Jinwoo Ahn
    University of Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Biochemistry 50:1359-67. 2011
    The cullin4A-RING E3 ubiquitin ligase (CRL4) is a multisubunit protein complex, comprising cullin4A (CUL4), RING H2 finger protein (RBX1), and DNA damage-binding protein 1 (DDB1)...
  78. pmc The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting
    Eva Dumbliauskas
    Institut de Biologie Moleculaire des Plantes, Centre National de la Recherche Scientifique, Unite Propre de Recherche, Conventionné avec l Université de Strasbourg, Strasbourg, France
    EMBO J 30:731-43. 2011
    ..Among putative CRL4 receptors we identified MULTICOPY SUPPRESSOR OF IRA1 (MSI1), which belongs to an evolutionary conserved protein ..
  79. doi Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis
    Yuri Matsumoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Allergol Int 60:87-92. 2011
    ..However, the molecular mechanisms that underlie SAR are only partially understood. The aim of the study was to identify novel genes related to SAR during natural exposure to pollens, by using microarray analysis...
  80. pmc CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 40:9-21. 2010
    ..We identify CRL4(Cdt2) as the principal E3 ubiquitin ligase responsible for Set8 proteolytic degradation in the S phase of the cell ..
  81. pmc Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells
    Takashi Ishii
    Graduate School of Life Science, University of Hyogo, Kouto 3 2 1, Kamigori, Ako gun, Hyogo 678 1297, Japan
    J Biol Chem 285:41993-2000. 2010
    The licensing factor Cdt1 is degraded by CRL4(Cdt2) ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage is induced in G(1) phase...
  82. pmc PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
    Gaston Soria
    Fundación Instituto Leloir CONICET, Universidad de Buenos Aires, Argentina
    DNA Repair (Amst) 9:358-64. 2010
    ..Moreover, conclusive reports identified the E3-ligase CRL4(CDT2) (CUL4-DDB1-CDT2) as the enzymatic complex that promotes p21 proteolysis when treatments such as UV ..
  83. pmc CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    Kenta Terai
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 37:143-9. 2010
    ..We show that the CRL4(Cdt2) E3 ubiquitin ligase complex promotes PCNA monoubiqutination in proliferating cells in the absence of external ..
  84. pmc Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
    Wei Li
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 140:477-90. 2010
    ..show that the closed, growth-inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4(DCAF1), and suppresses its activity. Depletion of DCAF1 blocks the promitogenic effect of inactivation of Merlin...
  85. pmc The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA
    Dong Hyun Kim
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mol Cell Biol 30:4120-33. 2010
    ..In this study, we show that the predominant E3 for Xic1 in the egg is the Cul4-DDB1-XCdt2 (Xenopus Cdt2) (CRL4(Cdt2)) ubiquitin ligase...
  86. doi Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes
    Marc Le Vee
    EA 4427 Signalisation et Réponse aux Agents Infectieux et Chimiques, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, Rennes, France
    Toxicol In Vitro 24:1775-81. 2010
    ..e. CYP1A1, CYP1A2, CYP1B1, ALDH3A1, IL17RB, FER1L3 and SLC7A5, when compared to TCDD-treated counterparts transfected with non-targeting small-interfering ..
  87. pmc Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancer
    Piiha Lotta Jerevall
    Department of Clinical and Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Breast Cancer Res 12:R53. 2010
    The HOXB13:IL17BR index has been identified to predict clinical outcome in the setting of adjuvant tamoxifen monotherapy of breast cancer...
  88. pmc Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase
    Hyun O Lee
    Curriculum in Genetics and Molecular Biology, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Biol Cell 21:3639-53. 2010
    DNA synthesis-coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4(Cdt2) E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase...
  89. pmc HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation
    Jinwoo Ahn
    Department of Structural Biology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 285:37333-41. 2010
    ..host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin ligase assembly (CRL4(DCAF1))...
  90. doi CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase function
    Claudia Kerzendorfer
    Human DNA Damage Response Disorders Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
    Mech Ageing Dev 132:366-73. 2011
    ..Herein, we focus on one member of the cullin family, namely the Cullin 4-RING E3 ligases (CRL4's)...
  91. ncbi A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity
    Y Shi
    Departments of Molecular Biology, Protein Development, Strategic Drug Development, and Cell Biology, Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    J Biol Chem 275:19167-76. 2000
    ..Together these results suggest that IL-17B may be a novel proinflammatory cytokine acting on a restricted set of target cell types. They also demonstrate the strength of genomic approaches in the unraveling of novel biological pathways...

Research Grants19

  1. Structural studies of cullin-based ubiquitin ligases
    Ning Zheng; Fiscal Year: 2010
    ..will be used to investigate how the substrate receptor subunits (DCAFs) of a newly identified family of CLRs, the CRL4 E3 complexes, are recruited to the ubiquitin ligase machinery...
  2. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2010
    ..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
  3. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2010
    ..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
  4. Tamoxifen biotransformation pathway pharmacogenomics
    MATTHEW PHILIP GOETZ; Fiscal Year: 2010
    ....
  5. Tamoxifen biotransformation pathway pharmacogenomics
    Matthew Goetz; Fiscal Year: 2009
    ....
  6. A Novel Breast Cancer Biomarker
    Dennis C Sgroi; Fiscal Year: 2010
    ..We have developed a novel real-time PCR assay, HOXB13:IL17BR-MGI, which is a robust, independent prognostic and predictive biomarker of both tamoxifen and aromatase inhibitor ..
  7. A Novel Breast Cancer Biomarker
    Dennis Sgroi; Fiscal Year: 2009
    ..This biomarker, consisting of a ratio of two genes, the homeobox gene HOXB13 and the interleukin 17B receptor gene, outperforms all existing biomarkers...