IL17RB

Summary

Gene Symbol: IL17RB
Description: interleukin 17 receptor B
Alias: CRL4, EVI27, IL17BR, IL17RH1, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17RB, IL-17Rh1, cytokine receptor CRL4, cytokine receptor-like 4, interleukin 17 receptor homolog 1, interleukin 17B receptor, interleukin-17 receptor B, interleukin-17B receptor
Species: human

Top Publications

  1. ncbi Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation
    H Wang
    The Unit for Clinical Systems Biology, Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Sahlgrenska Academy, University of Gothenburg, and The Pediatric Allergy Unit, The Queen Silvia Children s Hospital, Gothenburg, Sweden
    Clin Exp Allergy 40:1194-202. 2010
  2. ncbi Evi27 encodes a novel membrane protein with homology to the IL17 receptor
    E Tian
    Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Oncogene 19:2098-109. 2000
  3. ncbi Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome
    Piiha Lotta Jerevall
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, Linkoping, Sweden
    Breast Cancer Res Treat 107:225-34. 2008
  4. pmc PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
  5. pmc Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
    Hisanobu Oda
    Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 40:364-76. 2010
  6. ncbi Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer
    Graeme Walker
    Edinburgh Cancer Research Centre, and Department of Pathology, University of Edinburgh, Edinburgh, UK
    Gynecol Oncol 106:461-8. 2007
  7. pmc Sequence of the lid affects activity and specificity of Candida rugosa lipase isoenzymes
    Stefania Brocca
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, 20126 Milano, Italy
    Protein Sci 12:2312-9. 2003
  8. pmc The HOXB13 p.Gly84Glu mutation is not associated with the risk of breast cancer
    Mohammad R Akbari
    Women s College Research Institute, Women s College Hospital, University of Toronto, Toronto, Canada
    Breast Cancer Res Treat 136:907-9. 2012
  9. pmc Cullin4A and Cullin4B Are Interchangeable for HIV Vpr and Vpx Action through the CRL4 Ubiquitin Ligase Complex
    Hamayun John Sharifi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    J Virol 88:6944-58. 2014
  10. pmc Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation
    Hiroki Sakaguchi
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo, Japan
    PLoS ONE 7:e46480. 2012

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. ncbi Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation
    H Wang
    The Unit for Clinical Systems Biology, Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Sahlgrenska Academy, University of Gothenburg, and The Pediatric Allergy Unit, The Queen Silvia Children s Hospital, Gothenburg, Sweden
    Clin Exp Allergy 40:1194-202. 2010
    ..Allergen-challenged peripheral blood mononuclear cells (PBMCs) provide a human in vitro model of how antigen-presenting cells, CD4+ T cells and effector cells such as basophils interact in allergic inflammation...
  2. ncbi Evi27 encodes a novel membrane protein with homology to the IL17 receptor
    E Tian
    Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Oncogene 19:2098-109. 2000
    b>Evi27 is a common site of retroviral integration in BXH2 murine myeloid leukemias...
  3. ncbi Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome
    Piiha Lotta Jerevall
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, Linkoping, Sweden
    Breast Cancer Res Treat 107:225-34. 2008
    The two-gene expression ratio HOXB13:IL17BR has been proposed to predict the outcome of tamoxifen-treated breast cancer patients. We intended to examine whether this ratio can predict the benefit of 5 years vs...
  4. pmc PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
    ..Antigen (PCNA) promotes the DNA damage-induced degradation of the replication initiation factor Cdt1 via the CRL4(Cdt2) E3 ubiquitin ligase complex...
  5. pmc Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
    Hisanobu Oda
    Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Mol Cell 40:364-76. 2010
    ..response, PR-Set7 interaction with PCNA through a specialized "PIP degron" domain targets it for PCNA-coupled CRL4(Cdt2)-dependent proteolysis...
  6. ncbi Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer
    Graeme Walker
    Edinburgh Cancer Research Centre, and Department of Pathology, University of Edinburgh, Edinburgh, UK
    Gynecol Oncol 106:461-8. 2007
    ..To explore the predictive value of estrogen-regulated gene changes as indicators of sensitivity in ovarian cancer patients treated with the aromatase inhibitor Letrozole...
  7. pmc Sequence of the lid affects activity and specificity of Candida rugosa lipase isoenzymes
    Stefania Brocca
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, 20126 Milano, Italy
    Protein Sci 12:2312-9. 2003
    ..the role of the lid in CRL activity and specificity, we substituted the lid sequences from isoenzymes CRL3 and CRL4 in recombinant rCRL1, thus obtaining enzymes differing only in this stretch of residues...
  8. pmc The HOXB13 p.Gly84Glu mutation is not associated with the risk of breast cancer
    Mohammad R Akbari
    Women s College Research Institute, Women s College Hospital, University of Toronto, Toronto, Canada
    Breast Cancer Res Treat 136:907-9. 2012
    ..HOXB13 is overexpressed in breast cancer tissues and HOXB13 expression in combination with low expression of IL17BR is predictive for a tamoxifen response in ER-positive breast cancers...
  9. pmc Cullin4A and Cullin4B Are Interchangeable for HIV Vpr and Vpx Action through the CRL4 Ubiquitin Ligase Complex
    Hamayun John Sharifi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    J Virol 88:6944-58. 2014
    ..immunodeficiency virus (SIV) Vpr and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitination and proteasomal degradation of host proteins, including ones that block infection...
  10. pmc Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation
    Hiroki Sakaguchi
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo, Japan
    PLoS ONE 7:e46480. 2012
    ..When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation...
  11. pmc The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection
    Laurieann Casey Klockow
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Virology 444:191-202. 2013
    ..Vpr acts through the CRL4(DCAF1) ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands...
  12. pmc Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
    Nuri Ozturk
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 110:4980-5. 2013
    ..DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY and its ..
  13. pmc Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation
    Yasushi Shiomi
    Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo, Japan
    Mol Cell Biol 32:2279-88. 2012
    Recent work identified the E3 ubiquitin ligase CRL4(Cdt2) as mediating the timely degradation of Cdt1 during DNA replication and following DNA damage...
  14. pmc VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases
    Tadashi Nakagawa
    Department of Cell Proliferation, United Center for Advanced Research and Translational Medicine, Graduate School of Medicine, Tohoku University, Sendai 900 8575, Japan
    BMC Mol Biol 14:22. 2013
    ..DCAF1) to serve as a substrate recognition subunit for a member of both major classes of E3 ligase, the RING-type CRL4 ligase and the HECT-type EDD/UBR5 ligase...
  15. ncbi Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools
    Rasmus Vejrup-Hansen
    Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    J Cell Sci 127:2460-70. 2014
    ..Here, we report the characterization of Spd2, a protein with sequence similarity to Spd1. We show that Spd2 is a CRL4(Cdt2)-controlled IDP that functions together with Spd1 in the DNA damage response and in modulation of RNR ..
  16. pmc A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase
    Sufang Zhang
    From the Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595
    J Biol Chem 288:29550-61. 2013
    ..We demonstrate that CRL4(Cdt2), a key regulator of cell cycle progression that targets replication licensing factors, also targets the p12 ..
  17. pmc Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis
    María Luisa Irigoyen
    Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain
    Plant Cell 26:712-28. 2014
    ..Studies in both animals and plants have led to the identification of many CRL4 targets as well as specific regulatory mechanisms that modulate their function...
  18. ncbi Two-gene expression ratio as predictor for breast cancer treated with tamoxifen: evidence from meta-analysis
    Lin Zhao
    International Medical School, Tianjin Medical University, 300070, Tianjin, China
    Tumour Biol 35:3113-7. 2014
    A HOXB13-to-IL17BR expression ratio was previously identified to predict a clinical outcome of breast cancer patients treated with adjuvant tamoxifen...
  19. ncbi Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
    Anita K Gandhi
    Celgene Corporation, Summit, NJ, USA
    Br J Haematol 164:811-21. 2014
    ..target of lenalidomide and pomalidomide, is a substrate receptor of the cullin ring E3 ubiquitin ligase complex, CRL4(CRBN) ...
  20. ncbi CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins
    Chao Yu
    Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China
    Science 342:1518-21. 2013
    ..We found that a cullin-ring finger ligase-4 (CRL4) complex was crucial in this process...
  21. doi PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase
    Linda Clijsters
    Division of Cell Biology B5 and Division of Molecular Carcinogenesis B7, The Netherlands Cancer Institute NKI AvL, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    J Cell Sci 127:1336-45. 2014
    ..Similar to Cdt1, nuclear clearance of Cdc6 depends on an N-terminal PIP-box and the Cdt2-containing CRL4 complex...
  22. pmc CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing
    Canan Kuscu
    W M Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724
    Proc Natl Acad Sci U S A 111:1795-800. 2014
    ..in this organism, is a subunit of the Clr4 methyltransferase complex (CLRC), whose composition is reminiscent of a CRL4 type cullin-RING ubiquitin ligase (CRL) including its cullin Cul4, the RING-box protein Pip1, the DNA damage ..
  23. doi Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2
    Anna Popova
    Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Ruprecht Karls University of Heidelberg, Center of Excellence in Dermatology, The State of Baden Württemberg, Mannheim, Germany
    Immunobiology 217:321-8. 2012
    IL17RB is the receptor for IL17E, the only member of IL17 family promoting Th2 reactions. The mechanism of IL17BR regulation is poorly understood...
  24. ncbi Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function
    Tomoyuki Mori
    Structural Biology Laboratory, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara, 630 0192, Japan
    Genes Cells 19:603-19. 2014
    ..type 2 gene, has been shown to suppress tumorigenesis by inhibiting the Cullin 4-RING E3 ubiquitin ligase CRL4(DCAF) (1) in the nucleus...
  25. pmc Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer
    Wei wei Pan
    From the Life Sciences Institute, Zhejiang University, Hangzhou 310058
    J Biol Chem 288:29680-91. 2013
    ..We show here that CRL4 components are highly expressed in human epithelial ovarian cancer tissues...
  26. pmc Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage
    Kenta Terai
    From the Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908
    J Biol Chem 288:30509-14. 2013
    ..b>CRL4(Cdt2) is an E3 ligase that ubiquitinates and degrades p12 after UV treatment...
  27. ncbi A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
    Xiao Jun Ma
    Arcturus Bioscience, Inc, 2715 Loker Avenue West, Carlsbad, CA 92008, USA
    Cancer Cell 5:607-16. 2004
    ..An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers...
  28. pmc Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins
    Wei Wei
    School of Life Science, Tianjin University, Tianjin, China
    J Virol 88:583-91. 2014
    ..Vpx proteins recruit the DCAF1-CRL4 E3 ubiquitin ligase to trigger species-specific SAMHD1 degradation...
  29. pmc Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker
    Dennis C Sgroi
    Department of Pathology, Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Natl Cancer Inst 105:1036-42. 2013
    ..The HOXB13/IL17BR (H/I) biomarker predicts recurrence risk in ER-positive, lymph node-negative breast cancer patients...
  30. pmc The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells
    Agathe Bacquin
    Universite Paris Sud, CNRS UMR8200 Unit of Genetic Stability and Oncogenesis, Institut de Cancerologie Gustave Roussy, Villejuif, France
    Nucleic Acids Res 41:6501-13. 2013
    ..Intriguingly, after its re-localization, FBH1 is targeted for degradation by the Cullin-ring ligase 4-Cdt2 (CRL4(Cdt2))-PCNA pathway via a PCNA-interacting peptide (PIP) degron...
  31. pmc Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase
    Mario Rossi
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, NY 10016, USA
    Mol Cell 49:1159-66. 2013
    ..DCAF proteins are the substrate binding subunits of the Skp1-Cul1-F-box protein (SCF) and Cul4-RING protein ligase (CRL4) ubiquitin ligase complexes, respectively...
  32. pmc HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation
    Maria Delucia
    Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 288:19116-26. 2013
    ..restriction via a virion-associated virulence accessory factor, Vpx (Vpr in some SIVs), which loads SAMHD1 onto CRL4-DCAF1 E3 ubiquitin ligase for polyubiquitination, programming it for proteasome-dependent degradation...
  33. pmc DDB2 promotes chromatin decondensation at UV-induced DNA damage
    Martijn S Luijsterburg
    Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Cell Biol 197:267-81. 2012
    ..is stimulated by the damaged DNA-binding protein 2 (DDB2), which is part of a CUL4A-RING ubiquitin ligase (CRL4) complex. In this paper, we report a new function of DDB2 in modulating chromatin structure at DNA lesions...
  34. pmc HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1
    Jinwoo Ahn
    Department of Structural Biology and Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 287:12550-8. 2012
    ..factor of HIV-2/SIVsm viruses, which targets SAMHD1 for proteasome-dependent degradation, by reprogramming cellular CRL4(DCAF1) E3 ubiquitin ligase...
  35. pmc Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2
    Courtney G Havens
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 287:11410-21. 2012
    The E3 ubiquitin ligase Cullin-ring ligase 4-Cdt2 (CRL4(Cdt2)) is emerging as an important cell cycle regulator that targets numerous proteins for destruction in S phase and after DNA damage, including Cdt1, p21, and Set8...
  36. pmc The role of HIV-1 Vpr in promoting the infection of nondividing cells and in cell cycle arrest
    Hamayun J Sharifi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Curr Opin HIV AIDS 7:187-94. 2012
    ..Vpr and its HIV2/SIV paralogs Vpr and Vpx play in viral infection and pathogenesis showed that all three engage CRL4 ubiquitin ligase complexes. This association triggers ubiquitination and degradation of cellular substrates...
  37. doi Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses
    Chris J Corrigan
    King s College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    J Allergy Clin Immunol 128:116-24. 2011
    ..IL-25 is thought to participate in allergic inflammation by propagating T(h)2-type responses...
  38. pmc Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology
    Bryan C Petersen
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Nat Med 18:751-8. 2012
    ..b>Il17rb(-/-) mice showed reduced lung pathology after chronic allergen exposure and decreased type 2 cytokine production ..
  39. pmc CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10
    Manpreet Kaur
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Nucleic Acids Res 40:7332-46. 2012
    ..Hence, these results establish that Cul4-DDB1-VprBP ubiquitin ligase mediates the stress-induced proteolysis of replication factor, Mcm10...
  40. doi Merlin, a multi-suppressor from cell membrane to the nucleus
    Lu Zhou
    Clinical Neurobiology, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, UK
    FEBS Lett 586:1403-8. 2012
    ..In the nucleus, merlin suppresses the E3 ubiquitin ligase CRL4(DCAF1) to inhibit proliferation...
  41. pmc DNA methylation in multiple myeloma is weakly associated with gene transcription
    Sungwon Jung
    Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
    PLoS ONE 7:e52626. 2012
    ..Among the genes with methylation-expression correlations were IGF1R, DLC1, p16, and IL17RB. In conclusion, DNA methylation may directly regulate relatively few genes and suggests that additional studies ..
  42. pmc TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21
    Lei Zhang
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Proc Natl Acad Sci U S A 109:20937-42. 2012
    ..prevents Cdt2 from binding to p21, therefore blocking ubiquitylation and proteasomal degradation of p21 mediated by CRL4(Cdt2) E3 ligase...
  43. pmc The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability
    Ling Zhang
    Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL USA
    Cell Cycle 11:4378-84. 2012
    ..DDB2 is required for efficient repair of CPDs in chromatin and is a component of the CRL4 (DDB2) E3 ligase that targets XPC, histones and DDB2 itself for ubiquitination...
  44. pmc The role of PR-Set7 in replication licensing depends on Suv4-20h
    David B Beck
    Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Genes Dev 26:2580-9. 2012
    ..PR-Set7 is required for proper cell cycle progression and is subject to degradation by the CRL4(Cdt2) ubiquitin ligase complex as a function of the cell cycle and DNA damage...
  45. doi Gene polymorphisms of interleukin-17 and interleukin-17 receptor are associated with end-stage kidney disease
    Yang Gyun Kim
    Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
    Am J Nephrol 36:472-7. 2012
    ..However, the genetic relationship between end-stage renal disease (ESRD) and the T-helper 17 pathway has never been studied. In this study, we hypothesized that polymorphisms of IL-17 or their receptors may be associated with ESRD...
  46. pmc CRL4(CDT2) targets CHK1 for PCNA-independent destruction
    Jiwon Huh
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 33:213-26. 2013
    ..CDT1), cell cycle control (p21), and chromatin modification (SET8) for destruction by the CUL4-based E3 ligase (CRL4)...
  47. ncbi SAMHD1: a novel antiviral factor in intrinsic immunity
    Zhangming Chen
    Department of Immunology, Anhui Medical University, Hefei, Anhui Province 230032, China
    Future Microbiol 7:1117-26. 2012
    ..However, some viruses evolve Vpx to recruit SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase in the cytoplasm for proteasome-dependent degradation, by which these viruses relieve ..
  48. pmc Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
    Jennifer Lee
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Graduate School of Medical Sciences of Cornell University New York, NY, USA
    Front Oncol 2:21. 2012
    The cullin 4-RING ubiquitin ligase (CRL4) family employs multiple DDB1-CUL4 associated factors substrate receptors to direct the degradation of proteins involved in a wide spectrum of cellular functions...
  49. pmc Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer
    Rachel C Jankowitz
    Department of Medicine, Division of Hematology Oncology, UPMC, University of Pittsburgh Cancer Institute, 300 Halket Street, Suite 4628, Pittsburgh, PA 15213, USA
    Breast Cancer Res 13:R98. 2011
    Breast Cancer Index (BCI) combines two independent biomarkers, HOXB13:IL17BR (H:I) and the 5-gene molecular grade index (MGI), that assess estrogen-mediated signalling and tumor grade, respectively...
  50. pmc Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction
    R Schwandner
    Tularik Incorporated, South San Francisco, California 94080, USA
    J Exp Med 191:1233-40. 2000
    ..Together, these results indicate that TRAF6, but not TRAF2, is a crucial component in the IL-17 signaling pathway leading to proinflammatory responses...
  51. pmc Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans
    Seung Hwan Kim
    The Biological Laboratories, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Cell 32:757-66. 2008
    ..report that DNA damage triggers the degradation of POLH-1 and that degradation is mediated by the Cul4-Ddb1-Cdt2 (CRL4-Cdt2) pathway that has previously been shown to degrade the replication factor Cdt1 during S phase...
  52. doi Association of IL-17RB gene polymorphism with asthma
    Ji Sun Jung
    Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
    Chest 135:1173-80. 2009
    ..The activation of IL-17RB amplifies allergic-type inflammatory responses by inducing Jun kinase (or JNK), p38 mitogen-activated protein kinase (or MAPK), and nuclear factor-kappaB...
  53. pmc An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases
    Michael Hans Olma
    Swiss Federal Institute of Technology Zurich ETH, Institute of Biochemistry, 8093 Zurich, Switzerland
    J Cell Sci 122:1035-44. 2009
    ..The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage...
  54. doi Genomic predictors of outcome and treatment response in breast cancer
    Lara Dunn
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Diagn Ther 13:73-90. 2009
    ..MammaPrint (Agendia BV), and the HOXB13/IL17BR (H/I) ratio; (Theros H/ISM; bioTheranostics)...
  55. pmc Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2
    Courtney G Havens
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 35:93-104. 2009
    Substrates of the E3 ubiquitin ligase CRL4(Cdt2), including Cdt1 and p21, contain a PCNA-binding motif called a PIP box. Upon binding of the PIP box to PCNA on chromatin, CRL4(Cdt2) is recruited and the substrate is ubiquitylated...
  56. pmc CRL4s: the CUL4-RING E3 ubiquitin ligases
    Sarah Jackson
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Trends Biochem Sci 34:562-70. 2009
    ..Many CRL4 complexes are involved in chromatin regulation and are frequently hijacked by different viruses.
  57. pmc PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
    Gaston Soria
    Fundación Instituto Leloir CONICET, Universidad de Buenos Aires, Argentina
    DNA Repair (Amst) 9:358-64. 2010
    ..Moreover, conclusive reports identified the E3-ligase CRL4(CDT2) (CUL4-DDB1-CDT2) as the enzymatic complex that promotes p21 proteolysis when treatments such as UV ..
  58. pmc CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
    Kenta Terai
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 37:143-9. 2010
    ..We show that the CRL4(Cdt2) E3 ubiquitin ligase complex promotes PCNA monoubiqutination in proliferating cells in the absence of external ..
  59. pmc Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
    Wei Li
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 140:477-90. 2010
    ..show that the closed, growth-inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4(DCAF1), and suppresses its activity. Depletion of DCAF1 blocks the promitogenic effect of inactivation of Merlin...
  60. pmc The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA
    Dong Hyun Kim
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mol Cell Biol 30:4120-33. 2010
    ..In this study, we show that the predominant E3 for Xic1 in the egg is the Cul4-DDB1-XCdt2 (Xenopus Cdt2) (CRL4(Cdt2)) ubiquitin ligase...
  61. ncbi Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes
    Marc Le Vee
    EA 4427 Signalisation et Réponse aux Agents Infectieux et Chimiques, Institut de Recherche en Santé, Environnement et Travail, Universite de Rennes 1, Rennes, France
    Toxicol In Vitro 24:1775-81. 2010
    ..e. CYP1A1, CYP1A2, CYP1B1, ALDH3A1, IL17RB, FER1L3 and SLC7A5, when compared to TCDD-treated counterparts transfected with non-targeting small-interfering ..
  62. pmc Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancer
    Piiha Lotta Jerevall
    Department of Clinical and Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Breast Cancer Res 12:R53. 2010
    The HOXB13:IL17BR index has been identified to predict clinical outcome in the setting of adjuvant tamoxifen monotherapy of breast cancer...
  63. pmc The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
    Youngjo Kim
    Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 USA
    Genes Dev 22:2507-19. 2008
    ..A vertebrate CUL4 CRL ubiquitin ligase (CRL4) complex containing Cdt2 as the substrate recognition subunit promotes proper DNA replication, in part, by ..
  64. pmc Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 14:5864-8. 2008
    ..P450 2D6 (CYP2D6) and the gene expression ratio of the homeobox 13 (HOXB13) to interleukin-17B receptor (IL17BR) are associated with tamoxifen resistance...
  65. pmc Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
    Benjamin A T Rodriguez
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 29:1459-65. 2008
    Several studies have reported that a high expression ratio of HOXB13 to IL17BR predicts tumor recurrence in node-negative, estrogen receptor (ER) alpha-positive breast cancer patients treated with tamoxifen...
  66. ncbi IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
    J Lee
    Department of Molecular Biology, Genentech Inc, San Francisco, California 94080, USA
    J Biol Chem 276:1660-4. 2001
    ..IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor ..
  67. ncbi Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production
    Mee Rhan Kim
    Departments of Functional Genomics, Pathology, Inflammation, Clinical Immunology, and Protein Science, Amgen Inc, Thousand Oaks, California 91302, USA
    Blood 100:2330-40. 2002
    ..In situ hybridization of transgenic tissues revealed that IL-17Rh1 (IL-17BR/Evi27), a receptor that binds IL-17E, is up-regulated...
  68. ncbi Limits of predictive models using microarray data for breast cancer clinical treatment outcome
    James F Reid
    Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Natl Cancer Inst 97:927-30. 2005
    ..We measured expression of the genes HOXB13 and IL17BR with real time-quantitative polymerase chain reaction and assessed the association between their expression and ..
  69. ncbi TNF-alpha and IFN-gamma inversely modulate expression of the IL-17E receptor in airway smooth muscle cells
    Stéphane Lajoie-Kadoch
    Meakins Christie Laboratories, McGill University, 3626 St Urbain Street, Montreal, Quebec, Canada H2X 2P2
    Am J Physiol Lung Cell Mol Physiol 290:L1238-46. 2006
    ..Our results suggest a potential proremodeling effect of IL-17E on airway smooth muscle cells through the induction of ECM and that its receptor is upregulated by proinflammatory conditions...
  70. ncbi IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts
    Severine Letuve
    Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 117:590-6. 2006
    ..IL-17E proinflammatory activity has been proposed to involve induction of cytokine and chemokine production. Recruitment of inflammatory cells may be mediated by tissue-resident cells...
  71. ncbi Genomic testing for sensitivity of breast cancer to hormonal therapy
    W Fraser Symmans
    Clin Cancer Res 12:1954-5. 2006
  72. ncbi A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen
    Matthew P Goetz
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 12:2080-7. 2006
    ..In the adjuvant treatment of estrogen receptor (ER)-positive breast cancer, additional markers are needed to identify women at high risk for recurrence...
  73. ncbi The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer
    Xiao Jun Ma
    AviaraDx Inc, Carlsbad, CA, USA
    J Clin Oncol 24:4611-9. 2006
    We previously identified three genes, HOXB13, IL17BR and CHDH, and the HOXB13:IL17BR ratio index in particular, that strongly predicted clinical outcome in breast cancer patients receiving tamoxifen monotherapy...
  74. ncbi The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer
    Zuncai Wang
    Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 13:6327-34. 2007
    We previously identified three genes, HOXB13, IL17BR, and CHDH, that strongly predict clinical outcome in estrogen receptor (ER)-positive breast cancer patients receiving tamoxifen monotherapy...
  75. doi Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen
    Marleen Kok
    Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Breast Cancer Res Treat 113:275-83. 2009
    ..For the first time, we compared these response profiles in an independent cohort of (neo)adjuvant systemic treatment naïve breast cancer patients treated with first-line tamoxifen for metastatic disease...
  76. ncbi A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer
    Xiao Jun Ma
    AviaraDx, Inc, San Diego, California, USA
    Clin Cancer Res 14:2601-8. 2008
    ..as follows: (a) to develop a simple gene expression index for tumor grade (molecular grade index or MGI), and (b) to determine whether MGI and our previously described HOXB13:IL17BR index together provide improved prognostic information.
  77. ncbi HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study
    Maurice P H M Jansen
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 25:662-8. 2007
    A HOXB13-to-IL17BR expression ratio was previously identified to predict clinical outcome of breast cancer patients treated with adjuvant tamoxifen...
  78. pmc Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase
    Hyun O Lee
    Curriculum in Genetics and Molecular Biology, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Biol Cell 21:3639-53. 2010
    DNA synthesis-coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4(Cdt2) E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase...
  79. pmc HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation
    Jinwoo Ahn
    Department of Structural Biology, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 285:37333-41. 2010
    ..host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin ligase assembly (CRL4(DCAF1))...
  80. pmc Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells
    Takashi Ishii
    Graduate School of Life Science, University of Hyogo, Kouto 3 2 1, Kamigori, Ako gun, Hyogo 678 1297, Japan
    J Biol Chem 285:41993-2000. 2010
    The licensing factor Cdt1 is degraded by CRL4(Cdt2) ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage is induced in G(1) phase...
  81. pmc Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase
    Courtney G Havens
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 25:1568-82. 2011
    ..Recently, an E3 ubiquitin ligase called CRL4(Cdt2) has been characterized, which couples proteolysis to DNA synthesis via an unusual mechanism that involves ..
  82. doi The molecular biology and novel treatments of vestibular schwannomas
    Brendan Fong
    Department of Neurological Surgery, University of California, Los Angeles, CA 90095 1761, USA
    J Neurosurg 115:906-14. 2011
    ..Recently, merlin was also shown to interact in the nucleus with E3 ubiquitin ligase CRL4(DCAF1)...
  83. doi Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL
    Baojun Wu
    Laboratory of Developmental Immunology, School of Life Science, Shandong University, Jinan, China
    Immunogenetics 63:835-45. 2011
    ..IL17RA and IL17RD are found in most vertebrates, whereas the other three, IL17RB, ILR17RC, and IL17RE, underwent some loss in vertebrates during evolution...
  84. pmc Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
    Kasia Hrecka
    Department of Molecular Biology and Microbiology, Case School of Medicine, Cleveland, Ohio 44106, USA
    Nature 474:658-61. 2011
    ..Vpx relieves the inhibition of lentivirus infection in macrophages by loading SAMHD1 onto the CRL4(DCAF1) E3 ubiquitin ligase, leading to highly efficient proteasome-dependent degradation of the protein...
  85. pmc Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
    Etsuko Shibata
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 31:3136-45. 2011
    b>CRL4(Cdt2) is a cullin-based E3 ubiquitin ligase that promotes the ubiquitin-dependent proteolysis of various substrates implicated in the control of cell cycle and various DNA metabolic processes such as DNA replication and repair...
  86. pmc The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis
    Yan Yin
    Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 356:51-62. 2011
    The Cullin-RING ubiquitin-ligase CRL4 controls cell cycle and DNA damage checkpoint response and ensures genomic integrity...
  87. pmc The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting
    Eva Dumbliauskas
    Institut de Biologie Moleculaire des Plantes, Centre National de la Recherche Scientifique, Unite Propre de Recherche, Conventionné avec l Université de Strasbourg, Strasbourg, France
    EMBO J 30:731-43. 2011
    ..Among putative CRL4 receptors we identified MULTICOPY SUPPRESSOR OF IRA1 (MSI1), which belongs to an evolutionary conserved protein ..
  88. doi Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis
    Yuri Matsumoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Allergol Int 60:87-92. 2011
    ..However, the molecular mechanisms that underlie SAR are only partially understood. The aim of the study was to identify novel genes related to SAR during natural exposure to pollens, by using microarray analysis...
  89. doi Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
    Andrea Scrima
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FEBS Lett 585:2818-25. 2011
    ..We will examine the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 focusing on shared architectural, targeting and regulatory principles...
  90. pmc Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation
    Estrella Guarino
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Nucleic Acids Res 39:5978-90. 2011
    Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiquitylation, which is triggered by DNA binding of proliferating cell nuclear antigen (PCNA)...
  91. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
    ..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known...
  92. doi DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transduction
    Jae Hoon Lee
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Plant Sci 180:352-7. 2011
    ..binding WD40) proteins have been reported as substrate receptors for cullin-RING ubiquitin ligase 4 complexes (CRL4), a family of E3 ligases...
  93. doi Using Drosophila S2 cells to measure S phase-coupled protein destruction via flow cytometry
    Jean M Davidson
    Department of Biology, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 782:205-19. 2011
    ..a motif called a PIP degron that mediates binding to chromatin bound PCNA at replication forks and recruits the CRL4(Cdt2) E3 ubiquitin ligase...
  94. doi Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression
    Jonathan Cooper
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Sci Signal 4:pt6. 2011
    ..unphosphorylated, growth-inhibiting form of Merlin accumulates in the nucleus and binds to the E3 ubiquitin ligase CRL4(DCAF1) to suppress its activity. Depletion of DCAF1 blocks the hyperproliferation caused by inactivation of Merlin...
  95. pmc Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor
    Srikripa Chandrasekaran
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7260, USA
    Mol Cell Biol 31:4405-16. 2011
    ..Two other CRL4(Cdt2) targets, the cyclin-dependent kinase (CDK) inhibitor p21 and the methyltransferase PR-Set7/Set8, are ..
  96. pmc CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 40:9-21. 2010
    ..We identify CRL4(Cdt2) as the principal E3 ubiquitin ligase responsible for Set8 proteolytic degradation in the S phase of the cell ..
  97. pmc CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
    Richard C Centore
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 40:22-33. 2010
    ..we show that Set8 is targeted for proteolysis in S phase and in response to DNA damage by the E3 ubiquitin ligase, CRL4(Cdt2)...
  98. pmc SETting the clock for histone H4 monomethylation
    Jennifer Lee
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Cell 40:345-6. 2010
    ..2010), Abbas et al. (2010), and Centore et al. (2010) determined that the H4K20 histone methyltransferase PR-Set7/Set8 is posttranslationally regulated by the PCNA-dependent CRL4(Cdt2) ubiquitin ligase.
  99. pmc Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1)
    Wei Li
    Sloan Kettering Institute for Cancer Research, New York, NY, USA
    Cell Cycle 9:4433-6. 2010
    ..have recently observed that Merlin translocates into the nucleus and binds to and inhibits the E3 ubiquitin ligase CRL4 (DCAF1) ...
  100. doi Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis
    Masato Michishita
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo 678 1297, Japan
    Genes Cells 16:12-22. 2011
    PCNA links Cdt1 and p21 for proteolysis by Cul4-DDB1-Cdt2 (CRL4(Cdt2) ) in the S phase and after DNA damage in mammalian cells. However, other PCNA-interacting proteins, such as ligase I, are not targets of CRL4(Cdt2) ...
  101. pmc A new regulator of the cell cycle: the PR-Set7 histone methyltransferase
    Shumin Wu
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Cycle 10:68-72. 2011
    ..regulated during different cell cycle phases by distinct enzymes including cdk1/cyclinB, Cdc14, SCF(Skp2), CRL4(cdt2) and APC(cdh1)...

Research Grants66

  1. The Role of CRL4-Cdt2 E3 Ubiquitin Ligase in Genomic Stability and Cancer
    TAREK A ABBAS; Fiscal Year: 2013
    ..Among these, the Cullin 4-based E3 ubiquitin ligase (CRL4) is emerging as a master regulator of cellular proliferation and genomic stability and is involved in multiple DNA ..
  2. The Role of CRL4-Cdt2 E3 Ubiquitin Ligase in Genomic Stability and Cancer
    TAREK A ABBAS; Fiscal Year: 2012
    ..Among these, the Cullin 4-based E3 ubiquitin ligase (CRL4) is emerging as a master regulator of cellular proliferation and genomic stability and is involved in multiple DNA ..
  3. Role of the SCF/FBX011 ubiquitin ligase in the control of cell proliferation
    Michele Pagano; Fiscal Year: 2013
    ..Cdt2 belongs to the family of DCAF proteins that are the substrate receptors of multi-subunit E3 complexes known as CRL4 (Cul4-Ring- ligase). CRL4Cdt2 controls the degradation of key regulators of proliferation (Cdt1, p21, Set8, etc...
  4. Function and Mechanism of CUL4 E3 Ligases in Human Diseases
    Yue Xiong; Fiscal Year: 2013
    ..We also discovered that cullin 3 and cullin 4 could assemble as many as 200 and 100 distinct CRL3 and CRL4 E3 complexes, respectively...
  5. In Vivo Interactome and Dynamics of Cullin-Ring Ligases
    Scott D Rychnovsky; Fiscal Year: 2013
    ..specific aims: 1) To define the in vivo interactome of CRL complexes as they occur in living cells;2) To unravel the in vivo interaction dynamics of CRL4 complexes during DNA damage response to elucidate their function and regulation.
  6. The Role of CRL4-Cdt2 E3 Ubiquitin Ligase in Genomic Stability and Cancer
    TAREK A ABBAS; Fiscal Year: 2010
    ..Among these, the Cullin 4-based E3 ubiquitin ligase (CRL4) is emerging as a master regulator of cellular proliferation and genomic stability and is involved in multiple DNA ..
  7. Mechanism of CRL4-Cdt2, an S phase-specific ubiquitin ligase
    Johannes Walter; Fiscal Year: 2013
    ..4) Elucidate how CRL4Cdt2 activity is coupled to DNA-bound PCNA. Together, the experiments will explore the biology and mechanism of a new S phase-specific proteolysis pathway that acts as an essential custodian of genome integrity. ..
  8. Role of the SCF/FBX011 ubiquitin ligase in the control of cell proliferation
    Michele Pagano; Fiscal Year: 2013
    ..Cdt2 belongs to the family of DCAF proteins that are the substrate receptors of multi-subunit E3 complexes known as CRL4 (Cul4-Ring- ligase). CRL4Cdt2 controls the degradation of key regulators of proliferation (Cdt1, p21, Set8, etc...
  9. Structural studies of cullin-based ubiquitin ligases
    Ning Zheng; Fiscal Year: 2013
    ..will be used to investigate how the substrate receptor subunits (DCAFs) of a newly identified family of CLRs, the CRL4 E3 complexes, are recruited to the ubiquitin ligase machinery...
  10. Structural studies of cullin-based ubiquitin ligases
    Ning Zheng; Fiscal Year: 2009
    ..will be used to investigate how the substrate receptor subunits (DCAFs) of a newly identified family of CLRs, the CRL4 E3 complexes, are recruited to the ubiquitin ligase machinery...
  11. Structural studies of cullin-based ubiquitin ligases
    Ning Zheng; Fiscal Year: 2010
    ..will be used to investigate how the substrate receptor subunits (DCAFs) of a newly identified family of CLRs, the CRL4 E3 complexes, are recruited to the ubiquitin ligase machinery...
  12. A Novel Breast Cancer Biomarker
    Dennis Sgroi; Fiscal Year: 2005
    ..This biomarker, consisting of a ratio of two genes, the homeobox gene HOXB13 and the interleukin 17B receptor gene, outperforms all existing biomarkers...
  13. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2009
    ..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
  14. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2010
    ..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
  15. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2010
    ..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
  16. The Cullin-ROC Family of E3 Ubiquitin Ligases
    Yue Xiong; Fiscal Year: 2007
    ..are: (i) to determine the functions and substrates of CRLS in mitosis and in transcriptional regulation, (ii) to determine the substrate recruiting mechanism of CRL4 ligases, and (iii) to determine the function and mechanism of p170.
  17. A Novel Breast Cancer Biomarker
    Dennis C Sgroi; Fiscal Year: 2013
    ..We have developed a novel real-time PCR assay, HOXB13:IL17BR-MGI, which is a robust, independent prognostic and predictive biomarker of both tamoxifen and aromatase inhibitor ..
  18. Tamoxifen biotransformation pathway pharmacogenomics
    Matthew Goetz; Fiscal Year: 2009
    ....
  19. Tamoxifen biotransformation pathway pharmacogenomics
    MATTHEW PHILIP GOETZ; Fiscal Year: 2010
    ....
  20. THE ROLE OF SCF IN EOSINOPHIL LUNG INFLAMATION
    Nicholas Lukacs; Fiscal Year: 2001
    ..In addition, we will assess changes in airway physiology in normal and deficient allergic mice and elucidate the mechanism of SCF- induced mast cell activation. ..
  21. LUNG IMMUNOPATHOLOGY TRAINING
    Nicholas Lukacs; Fiscal Year: 2007
    ..Thus, this T32 has a proven record of training researchers and will continue to successfully train post-doctoral fellows in research related to lung diseases that effect large numbers of patients. ..
  22. Vpr as a Mediator Proteasomal Degradation
    CARLOS M DE NORONHA; Fiscal Year: 2010
    ..abstract_text> ..
  23. MOLECULAR BIOLOGY OF LENTIVIRAL VPR AND VPX PROTEINS
    Jacek Skowronski; Fiscal Year: 2009
    ....
  24. Vpr as a Mediator Proteasomal Degradation
    Carlos de Noronha; Fiscal Year: 2009
    ....
  25. Developmental Control of the Cell Cycle
    Robert J Duronio; Fiscal Year: 2010
    ..A detailed molecular description of cell cycle events during animal development is critical for our understanding of cell proliferation control, and how such control goes awry in diseases like cancer. ..
  26. TLR and Notch Ligand in RSV-induced Disease
    Nicholas Lukacs; Fiscal Year: 2009
    ..Understanding these important signaling mechanisms will allow the assessment of alterations during disease related to a lack of RSV clearance. ..
  27. Ubiquitin-Proteolytic Control of HOXA9 in Leukemogenesis
    Pengbo Zhou; Fiscal Year: 2010
    ..abstract_text> ..
  28. Regulation of Nucleotide Excision Repair by Proteolysis
    Pengbo Zhou; Fiscal Year: 2006
    ..Completion of the proposed studies will also shed light on how abnormal activation of CUL- 4A contributes to tumor development. ..
  29. Role of Cul5 E3 ubiquitin ligase in HIV Vif function
    Xiao Fang Yu; Fiscal Year: 2007
    ..This study should provide critical insight into the complex interplay between viral and host factors and may provide us with critical information regarding the design of effective intervention strategies for HIV. ..
  30. Regulation of Nucleotide Excision Repair by Proteolysis
    Pengbo Zhou; Fiscal Year: 2007
    ..Completion of the proposed studies will also shed light on how abnormal activation of CUL- 4A contributes to tumor development. ..
  31. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2003
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  32. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2002
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  33. VIRAL & HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2003
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  34. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2003
    ..Subjects who experience grade 2 toxicity will be immediately switched to the control diet and followed until they return to normal. ..
  35. C-C Chemokines in Eosinophil Airway Inflammation
    Nicholas Lukacs; Fiscal Year: 2003
    ....
  36. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2001
    ..Subjects who experience grade 2 toxicity will be immediately switched to the control diet and followed until they return to normal. ..
  37. GENETIC ANALYSIS OF E2F FUNCTION DURING DEVELOPMENT
    ROBERT DURONIO; Fiscal Year: 2002
    ....
  38. EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTL
    Xiao Fang Yu; Fiscal Year: 2001
    ..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
  39. MOLECULAR INTERACTIONS OF NEF AND AIDS PATHOGENESIS
    Jacek Skowronski; Fiscal Year: 2001
    ..Results from their studies will have implications for a rational design of effective strategies for pharmacological disruption of Nef functions that are required for AIDS pathogenesis. ..
  40. VIRAL AND HOST FACTORS ON HIV TRANSMISSION/PATHOGENESIS
    Xiao Fang Yu; Fiscal Year: 2000
    ..2) To study the influence of host genetic factors on HIV transmission and disease progression. The results of these studies should provide further insight into the mechanism of HIV transmission and pathogenesis. ..
  41. VIRAL DETERMINANTS OF DISEASE PROGRESSION IN HIV+ IDUS
    Xiao Fang Yu; Fiscal Year: 1999
    ..They should also provide information that may prove critical for the development of candidate preventive and therapeutic strategies. ..
  42. GENETIC ANALYSIS OF E2F FUNCTION DURING DEVELOPMENT
    ROBERT DURONIO; Fiscal Year: 2000
    ....
  43. EVALUATION OF HIV GAG DNA VACCINE TO MAX T HELPER/CTL
    Xiao Fang Yu; Fiscal Year: 1999
    ..C) Combination studies by using DNA vectors identified from this specific aim with DNA vectors identified from specific aim 1. ..
  44. MOLECULAR INTERACTIONS OF NEF AND AIDS PATHOGENESIS
    Jacek Skowronski; Fiscal Year: 1999
    ..Results from their studies will have implications for a rational design of effective strategies for pharmacological disruption of Nef functions that are required for AIDS pathogenesis. ..
  45. SCF in Allergic Airway Inflammation
    Nicholas Lukacs; Fiscal Year: 2004
    ..Our studies will also utilize new technology with siRNA constructs for inhibition of specific aspects of SCF-induced eosinophil activation. ..
  46. Protein Knockout Technology/Molecular Analysis of Cancer
    Pengbo Zhou; Fiscal Year: 2004
    ....
  47. Ubiquitin-Proteolytic Control of HOXA9 in Leukemogenesis
    Pengbo Zhou; Fiscal Year: 2007
    ....
  48. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2006
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  49. Role of Cul5 E3 ubiquitin ligasae in HIV Vif function
    Xiao Fang Yu; Fiscal Year: 2006
    ..This study should provide critical insight into the complex interplay between viral and host factors and may provide us with critical information regarding the design of effective intervention strategies for HIV. ..
  50. BEHAVIORAL AND VIROLOGIC FEATURES OF HIV+ IDUS IN CHINA
    Xiao Fang Yu; Fiscal Year: 1999
    ..These aims will be carried out in Guangxi Province through a longitudinal investigation of 600 drug users about whom demographic, social, and drug use information will be collected and analyzed. ..
  51. GENETIC ANALYSIS OF E2F FUNCTION DURING DEVELOPMENT
    ROBERT DURONIO; Fiscal Year: 2006
    ....
  52. SCF in Allergic Airway Inflammation
    Nicholas Lukacs; Fiscal Year: 2006
    ..Our studies will also utilize new technology with siRNA constructs for inhibition of specific aspects of SCF-induced eosinophil activation. ..
  53. Nutrition in Medicine
    Steven Zeisel; Fiscal Year: 2006
    ..g. lite version, supplement index), and automate aspects of efficacy evaluation. 4) Provide ongoing technical support and materials via the web to maximize and maintain use of the full curriculum. ..
  54. Diethanolamine, brain development and adult memory
    Steven Zeisel; Fiscal Year: 2006
    ..abstract_text> ..
  55. Implications of HIV in Low HCV Clearance in Chinese IDUs
    Xiao Fang Yu; Fiscal Year: 2005
    ..The results of these studies should provide further insight into the mechanism of HCV clearance and the development of immunity which are critical for the development of effective vaccine and new treatment strategies. ..
  56. A Novel Breast Cancer Biomarker
    Dennis Sgroi; Fiscal Year: 2007
    ..This biomarker, consisting of a ratio of two genes, the homeobox gene HOXB13 and the interleukin 17B receptor gene, outperforms all existing biomarkers...
  57. A Novel Breast Cancer Biomarker
    Dennis Sgroi; Fiscal Year: 2006
    ..This biomarker, consisting of a ratio of two genes, the homeobox gene HOXB13 and the interleukin 17B receptor gene, outperforms all existing biomarkers...
  58. A Novel Breast Cancer Biomarker
    Dennis C Sgroi; Fiscal Year: 2010
    ..We have developed a novel real-time PCR assay, HOXB13:IL17BR-MGI, which is a robust, independent prognostic and predictive biomarker of both tamoxifen and aromatase inhibitor ..
  59. A Novel Breast Cancer Biomarker
    Dennis Sgroi; Fiscal Year: 2009
    ..This biomarker, consisting of a ratio of two genes, the homeobox gene HOXB13 and the interleukin 17B receptor gene, outperforms all existing biomarkers...