IL15RA

Summary

Gene Symbol: IL15RA
Description: interleukin 15 receptor subunit alpha
Alias: CD215, interleukin-15 receptor subunit alpha, interleukin 15 receptor alpha isoform EM2, interleukin 15 receptor alpha isoform IC2, interleukin 15 receptor alpha isoform IC3, interleukin 15 receptor alpha isoform IC4, interleukin 15 receptor alpha isoform IC5, interleukin 15 receptor alpha isoform IC6, interleukin 15 receptor alpha isoform IC7, interleukin 15 receptor alpha isoform IC8, interleukin 15 receptor, alpha
Species: human
Products:     IL15RA

Top Publications

  1. di Renzo L, Bigioni M, Bottini F, Del Gobbo V, Premrov M, Cianci R, et al. Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate. Eur Rev Med Pharmacol Sci. 2006;10:235-45 pubmed
    ..Possession of wild type homozygotes genotypes regarding IL-15Ralpha cytokine and 677C-->T MTHFR enzyme characterised NWO individuals. ..
  2. Pistilli E, Devaney J, Gordish Dressman H, Bradbury M, Seip R, Thompson P, et al. Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. Cytokine. 2008;43:45-53 pubmed publisher
    ..04), and baseline muscle quality (p=0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome. ..
  3. Giri J, Kumaki S, Ahdieh M, Friend D, Loomis A, Shanebeck K, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995;14:3654-63 pubmed
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2. ..
  4. Dubois S, Magrangeas F, Lehours P, Raher S, Bernard J, Boisteau O, et al. Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression. J Biol Chem. 1999;274:26978-84 pubmed
    ..Together, our data indicate that exon 2 splicing of human IL-15Ralpha is a natural process that might play regulatory roles at different levels. ..
  5. Pereno R, Giron Michel J, Gaggero A, Cazes E, Meazza R, Monetti M, et al. IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha. Oncogene. 2000;19:5153-62 pubmed
    ..Thus, IL-15Ralpha controls NF-kappaB activation, however differences in the intracellular trafficking of the IL-15 and/or IL-15Ralpha suggest a different biological role for this complex in MELP versus MELREO cells. ..
  6. Bergamaschi C, Bear J, Rosati M, Beach R, Alicea C, Sowder R, et al. Circulating IL-15 exists as heterodimeric complex with soluble IL-15R? in human and mouse serum. Blood. 2012;120:e1-8 pubmed publisher
    ..Analysis of the form of IL-15 present in either normal or lymphodepleted mice agrees with the human data. These results have important implications for development of assays and materials for clinical applications of IL-15. ..
  7. Brilot F, Strowig T, Roberts S, Arrey F, MUNZ C. NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. J Clin Invest. 2007;117:3316-29 pubmed
    ..We suggest that this synapse formation enables optimal NK cell activation by DCs during innate immune responses. ..
  8. Rubinstein M, Kovar M, Purton J, Cho J, Boyman O, Surh C, et al. Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci U S A. 2006;103:9166-71 pubmed
    ..Significantly, the results with IL-2, a soluble cytokine, are quite different; thus, IL-2 function is markedly inhibited by binding to soluble IL-2Ralpha. ..
  9. Anderson D, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem. 1995;270:29862-9 pubmed
    ..Furthermore, the IL15RA and IL2RA genes have a similar intron-exon organization and are closely linked in both human and murine genomes...
  10. Mariner J, Lantz V, Waldmann T, Azimi N. Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site. J Immunol. 2001;166:2602-9 pubmed
    ..These findings suggest a role for IL-15Ralpha in aberrant T cell proliferation observed in HTLV-I-associated diseases. ..

Detail Information

Publications73

  1. di Renzo L, Bigioni M, Bottini F, Del Gobbo V, Premrov M, Cianci R, et al. Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate. Eur Rev Med Pharmacol Sci. 2006;10:235-45 pubmed
    ..Possession of wild type homozygotes genotypes regarding IL-15Ralpha cytokine and 677C-->T MTHFR enzyme characterised NWO individuals. ..
  2. Pistilli E, Devaney J, Gordish Dressman H, Bradbury M, Seip R, Thompson P, et al. Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. Cytokine. 2008;43:45-53 pubmed publisher
    ..04), and baseline muscle quality (p=0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome. ..
  3. Giri J, Kumaki S, Ahdieh M, Friend D, Loomis A, Shanebeck K, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995;14:3654-63 pubmed
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2. ..
  4. Dubois S, Magrangeas F, Lehours P, Raher S, Bernard J, Boisteau O, et al. Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression. J Biol Chem. 1999;274:26978-84 pubmed
    ..Together, our data indicate that exon 2 splicing of human IL-15Ralpha is a natural process that might play regulatory roles at different levels. ..
  5. Pereno R, Giron Michel J, Gaggero A, Cazes E, Meazza R, Monetti M, et al. IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha. Oncogene. 2000;19:5153-62 pubmed
    ..Thus, IL-15Ralpha controls NF-kappaB activation, however differences in the intracellular trafficking of the IL-15 and/or IL-15Ralpha suggest a different biological role for this complex in MELP versus MELREO cells. ..
  6. Bergamaschi C, Bear J, Rosati M, Beach R, Alicea C, Sowder R, et al. Circulating IL-15 exists as heterodimeric complex with soluble IL-15R? in human and mouse serum. Blood. 2012;120:e1-8 pubmed publisher
    ..Analysis of the form of IL-15 present in either normal or lymphodepleted mice agrees with the human data. These results have important implications for development of assays and materials for clinical applications of IL-15. ..
  7. Brilot F, Strowig T, Roberts S, Arrey F, MUNZ C. NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha. J Clin Invest. 2007;117:3316-29 pubmed
    ..We suggest that this synapse formation enables optimal NK cell activation by DCs during innate immune responses. ..
  8. Rubinstein M, Kovar M, Purton J, Cho J, Boyman O, Surh C, et al. Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci U S A. 2006;103:9166-71 pubmed
    ..Significantly, the results with IL-2, a soluble cytokine, are quite different; thus, IL-2 function is markedly inhibited by binding to soluble IL-2Ralpha. ..
  9. Anderson D, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem. 1995;270:29862-9 pubmed
    ..Furthermore, the IL15RA and IL2RA genes have a similar intron-exon organization and are closely linked in both human and murine genomes...
  10. Mariner J, Lantz V, Waldmann T, Azimi N. Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site. J Immunol. 2001;166:2602-9 pubmed
    ..These findings suggest a role for IL-15Ralpha in aberrant T cell proliferation observed in HTLV-I-associated diseases. ..
  11. Khan I, Moretto M, Wei X, Williams M, Schwartzman J, Liew F. Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response. J Exp Med. 2002;195:1463-70 pubmed
    ..gondii challenge. To our knowledge, this is the first demonstration of the important role of host IL-15 in the development of antigen-specific memory CD8+ T cells against an intracellular infection. ..
  12. Diniz S, Pendeloski K, Morgun A, Chepelev I, Gerbase Delima M, Shulzhenko N. Tissue-specific expression of IL-15RA alternative splicing transcripts and its regulation by DNA methylation. Eur Cytokine Netw. 2010;21:308-18 pubmed publisher
    ..Therefore, this work shows a broad expression pattern of functional IL-15RA splicing forms and suggests a regulatory role of DNA methylation in IL-15RA transcript Var1 expression in mononuclear cells. ..
  13. Bouchaud G, Garrigue Antar L, Solé V, Quéméner A, Boublik Y, Mortier E, et al. The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha. J Mol Biol. 2008;382:1-12 pubmed publisher
    ..The soluble IL-15Ralpha sushi domain-IL-15 fusion protein is therefore able to bind and activate both the IL-15Rbeta/gamma and the IL-15Ralpha/beta/gamma receptors. ..
  14. Duitman E, Orinska Z, Bulanova E, Paus R, Bulfone Paus S. How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol. 2008;28:4851-61 pubmed publisher
  15. Mortier E, Bernard J, Plet A, Jacques Y. Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol. 2004;173:1681-8 pubmed
    ..These results suggest that IL-15R alpha shedding may play important immunoregulatory functions. ..
  16. Hanick N, Rickert M, Varani L, Bankovich A, Cochran J, Kim D, et al. Elucidation of the interleukin-15 binding site on its alpha receptor by NMR. Biochemistry. 2007;46:9453-61 pubmed
    ..The interface, as predicted here, leaves open the possibility of trans-presentation of IL-15 by IL-15Ralpha on an opposing cell. ..
  17. Mortier E, Quéméner A, Vusio P, Lorenzen I, Boublik Y, Grötzinger J, et al. Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins. J Biol Chem. 2006;281:1612-9 pubmed
    ..Such hyper-IL-15 fusion proteins appear to constitute potent adjuvants for the expansion of lymphocyte subsets. ..
  18. Lorenzen I, Dingley A, Jacques Y, Grötzinger J. The structure of the interleukin-15 alpha receptor and its implications for ligand binding. J Biol Chem. 2006;281:6642-7 pubmed
    ..IL-15Ralpha complex, which is essential for the biological effects of this important cytokine and which is not observed in other cytokine/cytokine receptor complexes. ..
  19. Zhao M, Wang J, Liao W, Li D, Li M, Wu H, et al. Increased 5-hydroxymethylcytosine in CD4(+) T cells in systemic lupus erythematosus. J Autoimmun. 2016;69:64-73 pubmed publisher
    ..e. SOCS1, NR2F6 and IL15RA, which were also confirmed by ChIP-qPCR...
  20. Guo Q, Lv S, Wu S, Tian X, Li Z. Association between single nucleotide polymorphism of IL15RA gene with susceptibility to ossification of the posterior longitudinal ligament of the spine. J Orthop Surg Res. 2014;9:103 pubmed publisher
    Previous studies reported the association between single nucleotide polymorphism (SNP) of IL15 receptor alpha (IL15RA) gene with susceptibility to ossification of the posterior longitudinal ligament of the spine (OPLL)...
  21. Kim D, Jeong Y, Chon J, Yoo S, Kim H, Kang S, et al. Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament. Cytokine. 2011;55:343-6 pubmed publisher
    ..The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL.
  22. Utsunomiya Y, Ribeiro Ã, Quintal A, Sangalli J, Gazola V, Paula H, et al. Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling. PLoS ONE. 2015;10:e0136749 pubmed publisher
    ..that serve as a cis-regulatory element for the expression of interleukin alpha receptors 2 (IL2RA) and 15 (IL15RA)...
  23. Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle Cezar F, Watkins J, et al. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res. 2014;74:4908-21 pubmed publisher
    ..an explanation for this apparent conundrum by defining TNBC cell subsets that overexpress the IL15 immune receptor IL15RA. This receptor usually forms a heterotrimer with the IL2 receptors IL2RB and IL2RG, which regulates the ..
  24. Laffin M, Fedorak R, Wine E, Dicken B, Madsen K. A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease. J Am Coll Surg. 2018;: pubmed publisher
    ..Genotype was assessed at 8 loci associated with adaptive immunity (SMAD3, IL10RB, IL15RA, BACH2, IL12B, IL18RAP, IFNGR2, and JAK2)...
  25. Arvidsson G, Henriksson J, Sander B, Wright A. Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patient. Haematologica. 2018;103:666-678 pubmed publisher
    ..From these genes, we suggest a core set of genes (CCL3, CCL4, DUSP4, ETV5, ICAM1, IL15RA, IL21R, IL4I1, MFSD2A, NFKB1, NFKBIE, SEMA7A, TMEM2) characteristic of cells undergoing cell-adhesion-mediated ..
  26. Sato N, Sabzevari H, Fu S, Ju W, Petrus M, Bamford R, et al. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R?. Blood. 2011;117:4032-40 pubmed publisher
  27. Vámosi G, Bodnar A, Vereb G, Jenei A, Goldman C, Langowski J, et al. IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells. Proc Natl Acad Sci U S A. 2004;101:11082-7 pubmed
    ..In addition, both alpha-chains were at least partially homodimerized/oligomerized, which could be the basis of distinct signaling pathways by the two cytokines. ..
  28. Loro E, Ramaswamy G, Chandra A, Tseng W, Mishra M, Shore E, et al. IL15RA is required for osteoblast function and bone mineralization. Bone. 2017;103:20-30 pubmed publisher
    Interleukin-15 receptor alpha (IL15RA) is an important component of interleukin-15 (IL15) pro-inflammatory signaling...
  29. Liu X, Zuo Y, Zhang W, Yang D, Xiong C, Zhang X. Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells. J Huazhong Univ Sci Technolog Med Sci. 2009;29:527-34 pubmed publisher
    ..The conclusion demonstrated from our results is that IFN-gamma and TNF-alpha play an important role in regulating the expression of IL-15 and IL-15Ralpha on the surface of HUVECs. ..
  30. Ouyang S, Hsuchou H, Kastin A, Pan W. TNF stimulates nuclear export and secretion of IL-15 by acting on CRM1 and ARF6. PLoS ONE. 2013;8:e69356 pubmed publisher
    ..We conclude that TNF abolishes nuclear localization of IL-15 and IL-15R? by acting on CRM1, and it facilitates exocytosis of IL-15 with the involvement of ARF6. ..
  31. Sakamoto S, Caaveiro J, Sano E, Tanaka Y, Kudou M, Tsumoto K. Contributions of interfacial residues of human Interleukin15 to the specificity and affinity for its private alpha-receptor. J Mol Biol. 2009;389:880-94 pubmed publisher
    ..IL15Ralpha complex, together with interactions in Region 3 of the interleukin, poses a stark contrast with the structurally related and sometimes functionally redundant interleukin 2. ..
  32. Carballo C, Castro D, Borrego J, Manchado M. Gene expression profiles associated with lymphocystis disease virus (LCDV) in experimentally infected Senegalese sole (Solea senegalensis). Fish Shellfish Immunol. 2017;66:129-139 pubmed publisher
    ..irf3, irf7, irf8, irf9, irf10), cytokines (il1b, il6, il8, il12 and tnfa) and their receptors (il1r, il8r, il10r, il15ra, il17r), chemokines (CXC-type, CC-type and IL-8), prostaglandins (cox-2), g-type lysozymes, hepcidin, complement ..
  33. Chertova E, Bergamaschi C, Chertov O, Sowder R, Bear J, Roser J, et al. Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15R? cytokine compared to IL-15 monomer. J Biol Chem. 2013;288:18093-103 pubmed publisher
    ..These identified properties of heterodimeric IL-15 provide a strong rationale for the evaluation of this molecule for clinical applications. ..
  34. Choi J, Lee E, Choi B, Sohn S. Therapeutic potency of Poly I:C in HSV-induced inflammation through up-regulation of IL-15 receptor alpha. Immunobiology. 2013;218:1119-30 pubmed publisher
    ..In BD patients, the frequencies of IL-15R? expression in PBMCs were also significantly different between the inactive and active disease states. These results suggest that IL-15R? is a relevant factor in BD. ..
  35. Dozio E, Malavazos A, Vianello E, Briganti S, Dogliotti G, Bandera F, et al. Interleukin-15 and soluble interleukin-15 receptor ? in coronary artery disease patients: association with epicardial fat and indices of adipose tissue distribution. PLoS ONE. 2014;9:e90960 pubmed publisher
    ..Future studies on the relationship between IL-15, visceral fat and characteristics of atherosclerotic plaques could help to better understand the complex biology of this cytokine. ..
  36. Choe J, Lee H, Kim S, Kim M, Park S, Kim S. The distinct expressions of interleukin-15 and interleukin-15 receptor ? in Behçet's disease. Rheumatol Int. 2013;33:2109-15 pubmed publisher
    ..01 for SLE, p < 0.01 for RA, and p < 0.05 for BD). IL-15 and IL-15R? system may be involved in the inflammatory process and pathogenesis of BD. ..
  37. Müller J, Waldmann T, Kruhlak M, Dubois S. Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15R? in human monocytes and dendritic cells. J Biol Chem. 2012;287:40328-38 pubmed publisher
    ..These data suggest that splice versions of IL-15R? determine the range of IL-15 activities. ..
  38. Pistilli E, Quinn L. From anabolic to oxidative: reconsidering the roles of IL-15 and IL-15R? in skeletal muscle. Exerc Sport Sci Rev. 2013;41:100-6 pubmed publisher
  39. Bouchaud G, Gehrke S, Krieg C, Kolios A, Hafner J, Navarini A, et al. Epidermal IL-15R? acts as an endogenous antagonist of psoriasiform inflammation in mouse and man. J Exp Med. 2013;210:2105-17 pubmed publisher
    ..Thus, stressed epidermal stromal cells use soluble IL-15R? to dampen chronic inflammatory skin disease. ..
  40. Ring A, Lin J, Feng D, Mitra S, Rickert M, Bowman G, et al. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol. 2012;13:1187-95 pubmed publisher
    ..Our results provide new insights for the development of specific immunotherapeutics based on IL-15 or IL-2. ..
  41. Tamzalit F, Barbieux I, Plet A, Heim J, Nedellec S, Morisseau S, et al. IL-15.IL-15R? complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells. Proc Natl Acad Sci U S A. 2014;111:8565-70 pubmed publisher
    ..IL-15R? complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15R? complex for their own proliferation and survival. ..
  42. Hansen M, Woetmann A, Krejsgaard T, Kopp K, Søkilde R, Litman T, et al. IFN-? primes T- and NK-cells for IL-15-mediated signaling and cytotoxicity. Mol Immunol. 2011;48:2087-93 pubmed publisher
  43. de Bakker B, Bodnar A, van Dijk E, Vámosi G, Damjanovich S, Waldmann T, et al. Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells. J Cell Sci. 2008;121:627-33 pubmed publisher
    ..Our results should aid understanding the action of the IL2R-IL15R system in T cell function and also might contribute to the more rationale design of IL2R- or IL15R-targeted immunotherapy agents for treating human leukemia. ..
  44. Yokota S, Yoshida O, Dou L, Spadaro A, Isse K, Ross M, et al. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production. J Immunol. 2015;194:6045-56 pubmed publisher
    ..These results indicate that IRF-1 promotes LTx I/R injury via hepatocyte IL-15/IL-15Rα production and suggest that targeting IRF-1 and IL-15/IL-15Rα may be effective in reducing I/R injury associated with LTx. ..
  45. Yin J, Liu C, Wang X, Wang L, Shi Y, Tang W, et al. Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population. Tumour Biol. 2014;35:6593-600 pubmed publisher
    ..case-control study to evaluate the genetic effects of interleukin 15 (IL15) and IL15 receptor alpha (IL15RA) functional single nucleotide polymorphisms (SNPs) on the pathogenesis of GCA...
  46. Desbois M, Le Vu P, Coutzac C, Marcheteau E, Béal C, Terme M, et al. IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists. J Immunol. 2016;197:168-78 pubmed publisher
    ..Altogether, this work provides evidence that the sushi-IL-15R?/IL-15 fusion protein RLI enhances antitumor activity of anti-PD-1 treatment and is a promising approach to stimulate host immunity. ..
  47. Hong E, Usiskin I, Bergamaschi C, Hanlon D, Edelson R, Justesen S, et al. Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity. J Biol Chem. 2016;291:8931-50 pubmed publisher
    ..The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Rα-coated nanoparticles for antigen delivery. ..
  48. Jacob C, Mykytyn K, Varcony T, Drabkin H. Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences. Mamm Genome. 1993;4:435-9 pubmed
    ..With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus. ..
  49. Van den Bergh J, Willemen Y, Lion E, Van Acker H, De Reu H, Anguille S, et al. Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity. Oncotarget. 2015;6:44123-33 pubmed publisher
    ..In conclusion, we report an attractive approach to improve antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15/IL-15Rα mRNA-engineered designer DC. ..
  50. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167:1-5 pubmed
    ..The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex. ..
  51. Klapa S, Schüler S, Pitann S, Klenerman P, Gross W, Lamprecht P. Increased frequency of IL-7 and IL-15 receptor alpha chain (CD127, CD215) co-expressing CD4(+) T cells in granulomatosis with polyangiitis (Wegener's). Clin Exp Rheumatol. 2012;30:S171 pubmed
  52. Yin J, Wang L, Shi Y, Shao A, Tang W, Wang X, et al. IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Mol Biol Rep. 2014;41:1951-7 pubmed publisher
    ..However, the statistical power of our study was limited because of the moderate sample size and absence of a validation cohort. Large well-designed studies are warranted to confirm our findings. ..
  53. Wu Z, Xu Y. IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation. J Mol Cell Biol. 2010;2:217-22 pubmed publisher
    ..These data support clinical testing IL-2/IL-15Ralpha-IgG1-Fc expanded NK cells in patients with prostate cancer and CLL. ..
  54. Badoual C, Bouchaud G, Agueznay N, Mortier E, Hans S, Gey A, et al. The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer. Cancer Res. 2008;68:3907-14 pubmed publisher
    ..Overall, these results support for the first time an original protumor role of sIL-15Ralpha in cancer. ..
  55. Kurowska M, Rudnicka W, Maslinska D, Maslinski W. Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. Ann N Y Acad Sci. 2002;966:441-5 pubmed
    ..The constitutive, but distinct, expression of IL-15 and its receptors in select human fetal brain structures suggests that IL-15 plays a role in their development and physiology. ..
  56. Seigel G, Manohar S, Bai Y, Ding D, Salvi R. An immortalized microglial cell line (Mocha) derived from rat cochlea. Mol Cell Neurosci. 2017;85:202-210 pubmed publisher
    ..and respond to lipopolysaccharide (LPS) stimulation by upregulation of genes (Cox2, ICAM-1, Il6r, Ccl2, Il13Ra and Il15Ra) as well as releasing cytokines (IL-1beta, IL-12, IL-13 and RANTES)...
  57. Comes A, Di Carlo E, Musiani P, Rosso O, Meazza R, Chiodoni C, et al. IFN-gamma-independent synergistic effects of IL-12 and IL-15 induce anti-tumor immune responses in syngeneic mice. Eur J Immunol. 2002;32:1914-23 pubmed
    ..These data show IFN-gamma-independent synergistic anti-tumor effects of IL-12 and IL-15, involving CD8+ cells and secondary chemokines and cytokines, such as TNF-alpha. ..
  58. Smyth C, Ginn S, Deakin C, Logan G, Alexander I. Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood. 2007;110:91-8 pubmed
    ..Collectively, these results confirm that signal transduction via the IL-15R, and hence NK ontogeny, is preferentially retained relative to the IL-7R as gammac expression becomes limiting. ..
  59. Chen J, Petrus M, Bamford R, Shih J, Morris J, Janik J, et al. Increased serum soluble IL-15R? levels in T-cell large granular lymphocyte leukemia. Blood. 2012;119:137-43 pubmed publisher
    ..It is conceivable that higher IL-15R? expression may lower IL-15 response threshold in vivo and, therefore, may contribute to the pathogenesis of the disease. ..
  60. Morris J, Ramlogan Steel C, Yu P, Black B, Mannan P, Allison J, et al. Vaccination with tumor cells expressing IL-15 and IL-15R? inhibits murine breast and prostate cancer. Gene Ther. 2014;21:393-401 pubmed publisher
  61. di Renzo L, Gloria Bottini F, Saccucci P, Bigioni M, Abenavoli L, Gasbarrini G, et al. Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. Int J Immunopathol Pharmacol. 2009;22:105-13 pubmed
    ..Our data underscore previous findings that suggest a potential role of IL-15 cytokine in NWO syndrome. ..
  62. Braun M, Björkström N, Gupta S, Sundström K, Ahlm C, Klingstrom J, et al. NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15R? expression. PLoS Pathog. 2014;10:e1004521 pubmed publisher
    ..The results add further insights into mechanisms behind the immunopathogenesis of hantavirus infections in humans and identify new possible targets for intervention. ..
  63. Riechman S, Balasekaran G, Roth S, Ferrell R. Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol (1985). 2004;97:2214-9 pubmed
    ..chronic changes in IL-15 protein in plasma and characterizing genetic variation in the IL-15 receptor-alpha gene (IL15RA)...
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    ..15R?/15 complexes represent a potent adjuvant for augmenting the efficacy of adoptive immunotherapy. Such cell-bound or soluble 15R?/15 complexes could be developed for use in combination immunotherapy approaches. ..
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    ..Besides, rs8177655 from IL15RA was also associated to mRNA IL-15 expression in CD patients...
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    ..Expression of both SSP and LSP forms of IL-15 appears to be conserved in many mammals, suggesting that SSP may be important for expressing a form of IL-15 with lower magnitude or duration of biological effects. ..
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    ..However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer. ..
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    ..Finally, some of the IL-15 mutants generated in this study displayed agonist or antagonist properties and may be useful as therapeutic agents. ..
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    ..These data support the use of mRNA-electroporated LCs, or moDCs supplemented with exogenous rhuIL-15, as vaccines for cancer immunotherapy to break tolerance against self-differentiation antigens shared by tumors...
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    ..51 × 10(-6)). This study applied a robust approach for testing the genetic basis of BDR and identified novel loci associated with this drug response in asthmatics. ..