Gene Symbol: IL-8
Description: C-X-C motif chemokine ligand 8
Alias: GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, interleukin-8, T-cell chemotactic factor, alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, interleukin 8, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating peptide 1, small inducible cytokine subfamily B, member 8, tumor necrosis factor-induced gene 1
Species: human
Products:     IL-8

Top Publications

  1. John A, Zhu Y, Brightling C, Pang L, Knox A. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. J Immunol. 2009;183:4682-92 pubmed publisher
    ..This is the first description of an abnormality in transcription factor binding altering chemokine expression in airway structural cells in asthma. ..
  2. Shahzad M, Arevalo J, Armaiz Pena G, Lu C, Stone R, Moreno Smith M, et al. Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J Biol Chem. 2010;285:35462-70 pubmed publisher
    ..Our recent findings suggest that chronic stress is associated with increased IL8 levels. Here, we examined the molecular and biological significance of IL8 in stress-induced tumor growth...
  3. Mahanta A, Kakati S, Baruah S. The association of IL-8-251T/A polymorphism with complicated malaria in Karbi Anglong district of Assam. Cytokine. 2014;65:210-6 pubmed publisher
    ..Surprisingly, decreased expression of TGF-?1 in uncomplicated malaria even in presence of high expressing mutant genotype was observed and needs to be investigated in context of the pool of activated cells producing the cytokine. ..
  4. Mahieux R, Lambert P, Agbottah E, Halanski M, Deng L, Kashanchi F, et al. Cell cycle regulation of human interleukin-8 gene expression by the human immunodeficiency virus type 1 Tat protein. J Virol. 2001;75:1736-43 pubmed
    ..Finally, we demonstrate that the presence of the proteasome inhibitor MG-132 inhibits the induction of NF-kappa B binding, as well as IL-8 expression, supporting the role of NF-kappa B. ..
  5. McCarron S, Edwards S, Evans P, Gibbs R, Dearnaley D, Dowe A, et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res. 2002;62:3369-72 pubmed
    ..05). These results suggest that single nucleotide polymorphisms associated with differential production of IL-8, IL-10, and VEGF are risk factors for PC, possibly acting via their influence on angiogenesis. ..
  6. Li G, Yue Y, Tian Y, Li J, Wang M, Liang H, et al. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. Cytokine. 2012;60:552-60 pubmed publisher
    ..MMP-1-1067 2G, MMP-3-1171 6A, MMP-9-1562 T and IL-8-251 A allele are associated with decreased susceptibility to CP in Chinese population. ..
  7. Hofman F, Chen P, Incardona F, Zidovetzki R, Hinton D. HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells. J Neuroimmunol. 1999;94:28-39 pubmed
    ..These data suggest that extracellular tat, especially in the presence of TNF, may be responsible for the local production of IL-8. ..
  8. Doll D, Keller L, Maak M, Boulesteix A, Siewert J, Holzmann B, et al. Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int J Colorectal Dis. 2010;25:573-81 pubmed publisher
    ..Furthermore, GRO-3 was related to metastasis formation, and IL-8 was associated with survival, suggesting a potential predictive power of these markers. ..
  9. Mortier A, Berghmans N, Ronsse I, Grauwen K, Stegen S, Van Damme J, et al. Biological activity of CXCL8 forms generated by alternative cleavage of the signal peptide or by aminopeptidase-mediated truncation. PLoS ONE. 2011;6:e23913 pubmed publisher
    ..A third category is generated through the modification of the arginine in the NH(2)-terminal region into citrulline by peptidylarginine deiminases and has weak potency to induce neutrophil extravasation. ..

More Information

Publications151 found, 100 shown here

  1. Yoon B, Choi N, Lee H, Cho K, Roh H. Induction of interleukin-8 from nasal epithelial cells during bacterial infection: the role of IL-8 for neutrophil recruitment in chronic rhinosinusitis. Mediators Inflamm. 2010;2010:813610 pubmed publisher
    ..MEC and IL-8 are major factors for neutrophil recruitment in nonallergic CRS. ..
  2. Finoti L, Corbi S, Anovazzi G, Teixeira S, Steffens J, Secolin R, et al. Association between IL8 haplotypes and pathogen levels in chronic periodontitis. Eur J Clin Microbiol Infect Dis. 2013;32:1333-40 pubmed publisher
    ..The aim of the present study was to investigate whether the genetic susceptibility to CP in individuals with the IL8 ATC/TTC haplotype is associated with subgingival levels of periodontopathogens...
  3. Cosgrove S, Chotirmall S, Greene C, McElvaney N. Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway. J Biol Chem. 2011;286:7692-704 pubmed publisher
    ..This study illustrates the proinflammatory effects of micro-bleeds in the CF lung, the process by which this occurs, and a potential therapeutic intervention. ..
  4. Schutyser E, Struyf S, Proost P, Opdenakker G, Laureys G, Verhasselt B, et al. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem. 2002;277:24584-93 pubmed
    ..This points to a delicate balance of chemokines in epithelial ovarian cancer and to a potentially major role for CXCL8 and CCL18 in this tumor. ..
  5. Yu Y, Gong R, Mu Y, Chen Y, Zhu C, Sun Z, et al. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. J Immunol. 2011;187:4844-60 pubmed publisher
    ..These new findings provide insights for our understanding of the mechanism by which inflammatory factors regulate each other in response to HBV infection. ..
  6. Kamangar F, Abnet C, Hutchinson A, Newschaffer C, Helzlsouer K, Shugart Y, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17:117-25 pubmed
    ..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals. ..
  7. Reeves E, Williamson M, Byrne B, Bergin D, Smith S, Greally P, et al. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol. 2010;184:1642-52 pubmed publisher
    ..In conclusion, a novel mechanism has been identified highlighting the potential of IL-8 to determine the fate of other inflammatory molecules, such as IL-18, within the inflammatory milieu of the CF lung. ..
  8. Wang Z, Yang Y, Yang H, Capó Aponte J, Tachado S, Wolosin J, et al. NF-?B feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells. Mol Vis. 2011;17:3137-46 pubmed
    ..Such regulation depends on NF-?B modulation of DUSP1 expression levels and associated changes in PKC? protein levels. ..
  9. Kargi A, Yalcin A, Erin N, Savas B, Polat H, Gorczynski R. IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer. Clin Lab. 2012;58:501-5 pubmed
    ..Our goal was to evaluate the possibility of using serum sTRAIL and IL8 as markers of treatment efficacy and prognosis in patients with metastatic colon cancer...
  10. Bergin D, Reeves E, Meleady P, Henry M, McElvaney O, Carroll T, et al. ?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. J Clin Invest. 2010;120:4236-50 pubmed publisher
    ..These results provide new insight into the mechanism underlying the effect of AAT augmentation therapy in the pulmonary disease associated with AAT deficiency. ..
  11. Lurje G, Zhang W, Schultheis A, Yang D, Groshen S, Hendifar A, et al. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer. Ann Oncol. 2008;19:1734-41 pubmed publisher
  12. Yang D, Huang H, Guan S, Zhu H, Zhang C, Zhao J, et al. Interleukin(IL)-4 promotion of CXCL-8 gene transcription is mediated by ERK1/2 pathway in human pulmonary artery endothelial cells. Mol Immunol. 2011;48:1784-92 pubmed publisher
    ..ERK1/2, rather than NF-?B, JNK and p38 MAPK signaling, plays a role in IL-4 induced chemokine activation. Our results suggest that inhibition of ERK1/2 may be a possible target for airway neutrophilia in allergic lung diseases. ..
  13. Roux P, Alfieri C, Hrimech M, Cohen E, Tanner J. Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression. J Virol. 2000;74:4658-65 pubmed
    ..These results suggest a new role for Vpr in the pathogenesis of HIV infection, namely, the activation of transcription factors NF-IL-6 and NF-kappaB. ..
  14. Terada H, Urano T, Konno H. Association of interleukin-8 and plasminogen activator system in the progression of colorectal cancer. Eur Surg Res. 2005;37:166-72 pubmed
    ..In conclusion, IL-8 is responsible to tumor progression and liver metastasis of CRC, and the activation of PAS induced by IL-8 as well as VEGF may play an important role in the progression of CRC. ..
  15. Zhang W, Stoehlmacher J, Park D, Yang D, Borchard E, Gil J, et al. Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer. Clin Colorectal Cancer. 2005;5:124-31 pubmed
    ..17; log-rank test). Overall, our data suggest that gene polymorphisms active in the EGFR pathway may be associated with the sensitivity of colorectal cancer patients to platinum-based chemotherapy. ..
  16. Chen Y, Shi M, Yu G, Qin X, Jin G, Chen P, et al. Interleukin-8, a promising predictor for prognosis of pancreatic cancer. World J Gastroenterol. 2012;18:1123-9 pubmed publisher
    ..In vivo tumorigenesis analysis further proved that tumor tissues from patients with higher serum IL-8 levels grew faster than those with lower IL-8 levels. IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer. ..
  17. Campa D, Zienolddiny S, Maggini V, Skaug V, Haugen A, Canzian F. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis. 2004;25:229-35 pubmed
    ..genes prostaglandin synthase-2/cyclooxygenase-2 (COX2/PTGS2), interleukin-6 (IL6), interleukin-8 (IL8) and peroxisome proliferator-activated receptor gamma (PPARg)...
  18. Oem J, Jackel Cram C, Li Y, Kang H, Zhou Y, Babiuk L, et al. Hepatitis C virus non-structural protein-2 activates CXCL-8 transcription through NF-kappaB. Arch Virol. 2008;153:293-301 pubmed publisher
    ..These results demonstrate that HCV NS2 up-regulates IL-8 transcription through NF-kappaB. This newly identified function increases our understanding of the role of HCV NS2 protein in virus-host interactions...
  19. Bhaumik D, Scott G, Schokrpur S, Patil C, Orjalo A, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009;1:402-11 pubmed
  20. Reis S, Leite K, Piovesan L, Pontes Junior J, Viana N, Abe D, et al. Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer. BMC Urol. 2012;12:18 pubmed publisher
    ..005). We have demonstrated that the overexpression of MMP-9 and higher expression of IL-8 are related to unfavorable prognostic factors of urothelial bladder cancer and tumor recurrence and may be useful in the follow up of the patients. ..
  21. Meissner M, Hrgovic I, Doll M, Naidenow J, Reichenbach G, Hailemariam Jahn T, et al. Peroxisome proliferator-activated receptor {delta} activators induce IL-8 expression in nonstimulated endothelial cells in a transcriptional and posttranscriptional manner. J Biol Chem. 2010;285:33797-804 pubmed publisher
    ..Therefore, our data provide the first evidence that PPAR? induces IL-8 expression in nonstimulated endothelial cells via transcriptional as well as posttranscriptional mechanisms. ..
  22. Wang B, Cleary P, Xu H, Li J. Up-regulation of interleukin-8 by novel small cytoplasmic molecules of nontypeable Haemophilus influenzae via p38 and extracellular signal-regulated kinase pathways. Infect Immun. 2003;71:5523-30 pubmed
    ..This work provides insight into essential molecular and cellular events that may impact on the pathogenesis of OM and COPD and identifies rational targets for anti-inflammatory intervention. ..
  23. Isse K, Harada K, Nakanuma Y. IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules. Liver Int. 2007;27:672-80 pubmed
    ..Neutrophilic infiltration around reactive bile ductules may be related to the IL-8 expressed in bile ductular epithelia, possibly induced by bacterial components and proinflammatory cytokines released locally. ..
  24. Merritt W, Lin Y, Spannuth W, Fletcher M, Kamat A, Han L, et al. Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth. J Natl Cancer Inst. 2008;100:359-72 pubmed publisher
    ..001) in the HeyA8 and SKOV3ip1 models, respectively. Increased IL-8 expression is associated with poor clinical outcome in human ovarian carcinoma, and IL-8 gene silencing decreases tumor growth through antiangiogenic mechanisms. ..
  25. Lindley I, Aschauer H, Seifert J, Lam C, Brunowsky W, Kownatzki E, et al. Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor. Proc Natl Acad Sci U S A. 1988;85:9199-203 pubmed
    The neutrophil-activating factor (NAF) purified from the conditioned medium of lipopolysaccharide-stimulated human monocytes was sequenced and found to consist of 72 amino acids: ..
  26. Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem. 2003;278:45777-84 pubmed
    ..We conclude that IL-6 can play an important role in insulin resistance in man and, furthermore, that it may act in concert with other cytokines that also are up-regulated in adipose cells in insulin resistance. ..
  27. Abdel Malak N, Srikant C, Kristof A, Magder S, Di Battista J, Hussain S. Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8. Blood. 2008;111:4145-54 pubmed publisher
  28. Freund A, Jolivel V, Durand S, Kersual N, Chalbos D, Chavey C, et al. Mechanisms underlying differential expression of interleukin-8 in breast cancer cells. Oncogene. 2004;23:6105-14 pubmed
  29. Van Damme J, Rampart M, Conings R, Decock B, Van Osselaer N, Willems J, et al. The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. Eur J Immunol. 1990;20:2113-8 pubmed
    Isolation of the human neutrophil activating protein (NAP) interleukin 8 (IL8) from leukocytes has revealed that it is structurally related to beta-thromboglobulin (beta TG) from platelets...
  30. Lee W, Tai D, Lan K, Li A, Hsu H, Lin E, et al. The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population. Clin Cancer Res. 2005;11:6431-41 pubmed
    ..22; 95% confidence interval, 1.12-4.40; P = 0.019) carcinomas. The IL-8 -251T allele is significantly associated with increased risk of gastric carcinoma, particularly the diffuse and mixed types in Chinese population. ..
  31. Tsai Y, Lin J, Wan L, Lin H, Tsai Y, Lee C, et al. Interleukin gene polymorphisms in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:693-8 pubmed publisher
    ..02). The data suggest that Taiwan Chinese carriers of the IL-8 +781 T allele, independent of the CFH Y402H polymorphism, are at increased risk of developing wet AMD. ..
  32. Matsuo Y, Ochi N, Sawai H, Yasuda A, Takahashi H, Funahashi H, et al. CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer. 2009;124:853-61 pubmed publisher
    ..Thus, corresponding receptors CXCR2 and CXCR4 are potential antiangiogenic and antimetastatic therapeutic targets in PaCa. ..
  33. Méndez Samperio P, Palma J, Vazquez A. Signals involved in mycobacteria-induced CXCL-8 production by human monocytes. J Interferon Cytokine Res. 2002;22:189-97 pubmed
    ..bovis. These results show intracellular signaling pathways and a transcription factor involved in the M. bovis-mediated upregulation of CXCL-8 biosynthesis and release by human monocytes. ..
  34. Singh R, Lokeshwar B. Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs. Mol Cancer. 2009;8:57 pubmed publisher
  35. Olivo Díaz A, Romero Valdovinos M, Gudiño Ramirez A, Reyes Gordillo J, Jimenez Gonzalez D, Ramirez Miranda M, et al. Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis. Parasitol Res. 2012;111:487-91 pubmed publisher
    ..0448 and p=0.0166). Our results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers...
  36. Asahara H, Tartare Deckert S, Nakagawa T, Ikehara T, Hirose F, Hunter T, et al. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol. 2002;22:2974-83 pubmed
    ..As p300 acted cooperatively with NAP-1 in stimulating transcription from a chromatin template in vitro, our results suggest a dual role of NAP-1-p300 complexes in promoting chromatin assembly and transcriptional activation. ..
  37. Rubie C, Frick V, Pfeil S, Wagner M, Kollmar O, Kopp B, et al. Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol. 2007;13:4996-5002 pubmed
    ..Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. ..
  38. Li A, Dubey S, Varney M, Dave B, Singh R. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol. 2003;170:3369-76 pubmed
    ..Our data suggest that IL-8 directly enhanced endothelial cell proliferation, survival, and MMP expression in CXCR1- and CXCR2-expressing endothelial cells and regulated angiogenesis. ..
  39. Ahluwalia T, Khullar M, Ahuja M, Kohli H, Bhansali A, Mohan V, et al. Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians. PLoS ONE. 2009;4:e5168 pubmed publisher
    ..Eight single nucleotide polymorphisms (SNPs) of pro-inflammatory cytokine genes (CCL2, TGFB1, IL8, CCR5, and MMP9) were genotyped in two independently ascertained type 2 diabetic cohorts with (DN) and without ..
  40. Gao L, Pan X, Jia J, Liang W, Rao L, Xue H, et al. IL-8 -251A/T polymorphism is associated with decreased cancer risk among population-based studies: evidence from a meta-analysis. Eur J Cancer. 2010;46:1333-43 pubmed publisher
    ..21, 95% CI, 1.07-1.37), whereas significantly decreased risk was found among population-based studies (OR=0.90, 95% CI, 0.83-0.97). This meta-analysis shows that IL-8 -251A/T polymorphism may play a complex role in cancer development. ..
  41. Corbi S, Anovazzi G, Finoti L, Kim Y, Capela M, Secolin R, et al. Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid. Arch Oral Biol. 2012;57:1355-61 pubmed publisher
    ..The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid (GCF), the concentration of ..
  42. Heinzmann A, Ahlert I, Kurz T, Berner R, Deichmann K. Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2004;114:671-6 pubmed
    ..Recently, 2 studies have found association of the polymorphism -251A of IL8 with RSV bronchiolitis...
  43. Dan H, Liu W, Zhou Y, Wang J, Chen Q, Zeng X. Association of interleukin-8 gene polymorphisms and haplotypes with oral lichen planus in a Chinese population. Inflammation. 2010;33:76-81 pubmed publisher
    ..029) while the -251 T/+781 C haplotype frequency was higher in the eOLP patients than in the healthy controls (P = 0.028). The study suggests that the IL-8 polymorphisms may be associated with the severity of OLP in this Chinese cohort. ..
  44. Pollicino T, Bellinghieri L, Restuccia A, Raffa G, Musolino C, Alibrandi A, et al. Hepatitis B virus (HBV) induces the expression of interleukin-8 that in turn reduces HBV sensitivity to interferon-alpha. Virology. 2013;444:317-28 pubmed publisher
    ..Moreover, HBx viral protein was recruited onto the IL-8 promoter and this was paralleled by IL8-bound histone hyperacetylation and by active recruitment of transcriptional coactivators...
  45. Chen J, Yao P, Yuan A, Hong T, Shun C, Kuo M, et al. Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res. 2003;9:729-37 pubmed
    ..Anti-inflammatory agents can suppress the induction of IL-8 mRNA expression seen in lung cancer cells after coculture with macrophages, and this suppression is mediated, in part, through the NF-kappaB pathway. ..
  46. Gouwy M, Struyf S, Noppen S, Schutyser E, Springael J, Parmentier M, et al. Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol Pharmacol. 2008;74:485-95 pubmed publisher
    ..These data indicate that for synergistic interaction between chemokines binding and signaling of the two chemokines via their proper receptors is necessary. ..
  47. Hacking D, Knight J, Rockett K, Brown H, Frampton J, Kwiatkowski D, et al. Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. Genes Immun. 2004;5:274-82 pubmed
  48. Huang C, Huo A, Tsai C, Chen C, Tsai F. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. J Clin Lab Anal. 2006;20:255-9 pubmed
    ..26, respectively). We also did not detect any association between the IL-6 and IL-8 genotype and clinical or laboratory profiles in SLE patients. The results suggest that the IL-6 and IL-8 gene polymorphisms are not related to SLE. ..
  49. Martin D, Galisteo R, Gutkind J. CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem. 2009;284:6038-42 pubmed publisher
    ..How this intracellular pool of VEGF is regulated is still not understood. Here, we found that CXCL8/IL8, a potent proangiogenic and inflammatory chemokine, up-regulates VEGF mRNA and protein levels in endothelial cells ..
  50. Qin X, Deng Y, Liao X, Mo C, Li X, Wu H, et al. The IL-8 gene polymorphisms and the risk of the hepatitis B virus/infected patients. DNA Cell Biol. 2012;31:1125-30 pubmed publisher
    ..48, 95% CI 0.25-0.92, p=0.027). The +781C/T polymorphism of IL-8 was not found relevant to the liver diseases. This study indicated that the IL-8 gene -251 AA genotype might be a protect factor for LC. ..
  51. Heidemann J, Ogawa H, Dwinell M, Rafiee P, Maaser C, Gockel H, et al. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem. 2003;278:8508-15 pubmed
    ..The chemokine interleukin 8 (IL-8; CXCL8) exerts potent angiogenic properties on endothelial cells through interaction with its cognate ..
  52. Hoffmann E, Thiefes A, Buhrow D, Dittrich Breiholz O, Schneider H, Resch K, et al. MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factors. J Biol Chem. 2005;280:9706-18 pubmed
    ..Relative to c-Fos, the delayed recruitment of Fra-1 to the IL-8 promoter provides an example how AP-1 subunits may dampen excessive chemokine synthesis. ..
  53. Vogiatzi K, Apostolakis S, Voudris V, Thomopoulou S, Kochiadakis G, Spandidos D. Interleukin 8 and susceptibility to coronary artery disease: a population genetics perspective. J Clin Immunol. 2008;28:329-35 pubmed publisher
    b>Interleukin 8 is a strong chemoattractant factor for neutrophils and T lymphocytes...
  54. Bartling T, Drumm M. Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models. Am J Respir Cell Mol Biol. 2009;40:58-65 pubmed publisher
    ..The expression of inflammatory genes, like interleukin 8 (IL8), involves chromatin remodeling through histone acetylation...
  55. Apostolakis S, Vogiatzi K, Amanatidou V, Spandidos D. Interleukin 8 and cardiovascular disease. Cardiovasc Res. 2009;84:353-60 pubmed publisher
    ..In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed. ..
  56. Huang D, Ding Y, Zhou M, Rini B, Petillo D, Qian C, et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res. 2010;70:1063-71 pubmed publisher
    ..Our results reveal IL-8 as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sunitinib in this malignancy. ..
  57. Scarel Caminaga R, Kim Y, Viana A, Curtis K, Corbi S, Sogumo P, et al. Haplotypes in the interleukin 8 gene and their association with chronic periodontitis susceptibility. Biochem Genet. 2011;49:292-302 pubmed publisher
    ..We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians. ..
  58. Maxwell P, Coulter J, Walker S, McKechnie M, Neisen J, McCabe N, et al. Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma. Eur Urol. 2013;64:177-88 pubmed publisher
    ..The current absence of clinical validation is a limitation of the study. PTEN loss induces a selective upregulation of CXCL8 signalling that sustains the growth and survival of PTEN-deficient prostate epithelium. ..
  59. Clore G, Appella E, Yamada M, Matsushima K, Gronenborn A. Determination of the secondary structure of interleukin-8 by nuclear magnetic resonance spectroscopy. J Biol Chem. 1989;264:18907-11 pubmed
    ..As a result, the two units of the dimer form a contiguous six-stranded anti-parallel beta-sheet. The secondary structure of IL-8 is similar to that found in the crystal structure of the sequence related protein platelet factor 4. ..
  60. Lane B, Lore K, Bock P, Andersson J, Coffey M, Strieter R, et al. Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J Virol. 2001;75:8195-202 pubmed
  61. Rezaie Majd A, Maca T, Bucek R, Valent P, Müller M, Husslein P, et al. Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002;22:1194-9 pubmed
    ..Our data show that simvastatin is anti-inflammatory through the downregulation of cytokines in the endothelium and leukocytes. These effects may explain some of the clinical benefits of these drugs in the treatment of atherosclerosis. ..
  62. Hartman Z, Poage G, den Hollander P, Tsimelzon A, Hill J, Panupinthu N, et al. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res. 2013;73:3470-80 pubmed publisher
    ..Together these findings offer a rationale for dual inhibition of IL-6/IL-8 signaling as a therapeutic strategy to improve outcomes for patients with TNBCs. ..
  63. Nakanaga T, Nadel J, Ueki I, Koff J, Shao M. Regulation of interleukin-8 via an airway epithelial signaling cascade. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1289-96 pubmed
    ..This pathway, which also regulates mucin production in human airways, provides mechanisms for killing foreign organisms and for their clearance. ..
  64. Vinagre R, Corvelo T, Arnaud V, Leite A, Barile K, Martins L. Determination of strains of Helicobacter pylori and of polymorphism in the interleukin-8 gene in patients with stomach cancer. Arq Gastroenterol. 2011;48:46-51 pubmed
    ..Polymorphism in interleukin 8 (-251) was determined by the PCR-restriction fragment length polymorphism reaction and sequencing...
  65. Kim Y, Reed W, Wu W, Bromberg P, Graves L, Samet J. Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1028-35 pubmed
    ..These results suggested that Zn(2+)-induced inhibition of phosphatase activity is an initiating event in MAPK and AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells. ..
  66. Singh S, Wu S, Varney M, Singh A, Singh R. CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation. Microvasc Res. 2011;82:318-25 pubmed publisher
    ..Together, these data demonstrate that CXCR1 and CXCR2 expression plays a critical role in regulating multiple biological activities in human microvascular endothelial cells. ..
  67. Kim S, Lewis C, Nadel J. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011;317:2650-60 pubmed publisher
    ..Thus, we conclude that a positive feedback pathway involving COX-2/PGE2/EP3 receptor-dependent EGFR reactivation exaggerates IL-8 production in NCI-H292 cancer cells but not in NHBE (normal) cells. ..
  68. van den Berg A, Kuiper M, Snoek M, Timens W, Postma D, Jansen H, et al. Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells. Am J Respir Cell Mol Biol. 2005;33:97-104 pubmed
    ..This poses the interesting concept that by releasing IL-17 from memory T cells, the adaptive immune system instructs lung structural cells as part of the innate immune system to respond more vigorously. ..
  69. Zimmermann H, Seidler S, Gassler N, Nattermann J, Luedde T, Trautwein C, et al. Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS ONE. 2011;6:e21381 pubmed publisher
    ..IL-8 is strongly activated in CLD, thus likely contributing to hepatic inflammation. Our study suggests a novel role of IL-8 for recruitment and activation of hepatic macrophages via CXCR1 in human liver cirrhosis. ..
  70. Aoki M, Pawankar R, Niimi Y, Kawana S. Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES. Int Arch Allergy Immunol. 2003;130:216-23 pubmed
    ..Furthermore, mast cells may also regulate lymphocytic infiltration through the production of IL-8 and RANTES. ..
  71. Chang Y, Hsieh S, Chen M, Lin W. Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation. Exp Cell Res. 2002;278:166-74 pubmed
    ..This suggests that IL-8 induction by LTbetaR is via TRAFs-elicited signaling pathways, including NIK/IKK-dependent NF-kappaB activation and ASK/MKK/JNK-dependent AP-1 activation. ..
  72. Li J, Kartha S, Iasvovskaia S, Tan A, Bhat R, Manaligod J, et al. Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol. 2002;283:L690-9 pubmed
    ..We conclude that, in human airway epithelial cells, MAP kinases may regulate IL-8 promoter activity by NF-kappaB-dependent (in the case of JNK) and -independent (ERK) processes, as well as by posttranscriptional mechanisms (p38). ..
  73. Méndez Samperio P, Palma Barrios J, Vázquez Hernández A, García Martínez E. Secretion of interleukin-8 by human-derived cell lines infected with Mycobacterium bovis. Mediators Inflamm. 2004;13:45-9 pubmed
    ..bovis-induced IL-8 secretion in monocytic or epithelial cells. Furthermore, the results showed that calcium influx had a direct effect on IL-8 secretion in U937 cells or HEp-2 cells infected with M. bovis. ..
  74. Vanaudenaerde B, Wuyts W, Geudens N, Dupont L, Schoofs K, Smeets S, et al. Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. Am J Transplant. 2007;7:76-82 pubmed
    ..We linked this improvement to a reduction in airway neutrophilia and IL8. In the present study, we further investigated the intracellular mechanisms of azithromycin, looking at the ..
  75. Ben Nasr H, Chahed K, Mestiri S, Bouaouina N, Snoussi K, Chouchane L. Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma. Hum Immunol. 2007;68:761-9 pubmed
    ..Our findings suggest that the IL-8 promoter polymorphism is associated with increased nasopharyngeal carcinoma risk, particularly in males, as well as disease progress, supporting our hypothesis for IL-8 involvement in NPC pathogenesis. ..
  76. Kamali Sarvestani E, Aliparasti M, Atefi S. Association of interleukin-8 (IL-8 or CXCL8) -251T/A and CXCR2 +1208C/T gene polymorphisms with breast cancer. Neoplasma. 2007;54:484-9 pubmed
    ..6% and 7.1%, respectively; p=0.07). In conclusion, IL-8 -251T/A polymorphism is associated with development of invasive ductal carcinoma type of breast cancer while CXCR2 +1208C/T polymorphism may affect the disease progression. ..
  77. Rolny C, Capparuccia L, Casazza A, Mazzone M, Vallario A, Cignetti A, et al. The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. J Exp Med. 2008;205:1155-71 pubmed publisher
    ..In conclusion, we report that SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion and recruitment of macrophages coupled to the suppression of tumor growth. ..
  78. Kim Y, Viana A, Curtis K, Orrico S, Cirelli J, Scarel Caminaga R. Lack of association of a functional polymorphism in the interleukin 8 gene with susceptibility to periodontitis. DNA Cell Biol. 2009;28:185-90 pubmed publisher
    ..The IL8 gene contains a functional single-nucleotide polymorphism (SNP) (rs4073) in its promoter region that may influence ..
  79. Ritter B, Kilian P, Reboll M, Resch K, Distefano J, Frank R, et al. Differential effects of multiplicity of infection on Helicobacter pylori-induced signaling pathways and interleukin-8 gene transcription. J Clin Immunol. 2011;31:60-8 pubmed publisher
    ..Thus, the major virulence factors of H. pylori CagA, VacA, and DupA might play a minor role in the level of IL-8 gene response to a high bacterial load. ..