IL-8

Summary

Gene Symbol: IL-8
Description: interleukin 8
Alias: CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, T-cell chemotactic factor, alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, interleukin-8, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating peptide 1, small inducible cytokine subfamily B, member 8, tumor necrosis factor-induced gene 1
Species: human

Top Publications

  1. ncbi IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    Aihua Li
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 170:3369-76. 2003
  2. pmc IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    Romaine I Fernando
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Res 71:5296-306. 2011
  3. doi CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hepatology 55:807-20. 2012
  4. pmc The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth
    Rajendra Kumar Singh
    Department of Urology and Radiation Oncology, Sylvester Cancer Center, University of Miami School of Medicine, Miami, FL, USA
    Cancer Res 71:3268-77. 2011
  5. doi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
  6. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
  7. pmc Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1063-71. 2010
  8. pmc Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    Arturo V Orjalo
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 106:17031-6. 2009
  9. pmc Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis
    Mian M K Shahzad
    Department of Gynecologic Oncology, RNA, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:35462-70. 2010
  10. doi Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts
    Kwok Man Tong
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    Cell Signal 20:1478-88. 2008

Research Grants

Detail Information

Publications260 found, 100 shown here

  1. ncbi IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    Aihua Li
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 170:3369-76. 2003
    ..Our data suggest that IL-8 directly enhanced endothelial cell proliferation, survival, and MMP expression in CXCR1- and CXCR2-expressing endothelial cells and regulated angiogenesis...
  2. pmc IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    Romaine I Fernando
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Res 71:5296-306. 2011
    ..Our results also indicate the essential role of interleukin 8 (IL-8) signaling for the acquisition and/or maintenance of the mesenchymal and invasive features of Brachyury-..
  3. doi CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hepatology 55:807-20. 2012
    ..Further, in its role as a liver TIC marker CD133 also plays a functional part in regulating tumorigenesis of liver TICs by way of regulating NTS, IL-8, CXCL1, and MAPK signaling...
  4. pmc The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth
    Rajendra Kumar Singh
    Department of Urology and Radiation Oncology, Sylvester Cancer Center, University of Miami School of Medicine, Miami, FL, USA
    Cancer Res 71:3268-77. 2011
    ..Together, these results reveal a novel mechanism of ligand-independent growth promotion by CXCR7 and its coregulation by the proinflammatory factor IL-8 in prostate cancer...
  5. doi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
    ..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
  6. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..We conclude that IL-6 can play an important role in insulin resistance in man and, furthermore, that it may act in concert with other cytokines that also are up-regulated in adipose cells in insulin resistance...
  7. pmc Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    Dan Huang
    Laboratory of Cancer Genetics, Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 70:1063-71. 2010
    ..Our results reveal IL-8 as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sunitinib in this malignancy...
  8. pmc Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
    Arturo V Orjalo
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 106:17031-6. 2009
    ..Thus, cell surface IL-1alpha is an essential cell-autonomous regulator of the senescence-associated IL-6/IL-8 cytokine network...
  9. pmc Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis
    Mian M K Shahzad
    Department of Gynecologic Oncology, RNA, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:35462-70. 2010
    ..001). Our findings indicate that neurobehavioral stress leads to FosB-driven increases in IL8, which is associated with increased tumor growth and metastases. These findings may have implications for ovarian cancer management...
  10. doi Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts
    Kwok Man Tong
    Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan
    Cell Signal 20:1478-88. 2008
    ..These results suggest that leptin increased IL-8 production in synovial fibroblast via the OBRl/JAK2/STAT3 pathway, as well as the activation of IRS1/PI3K/Akt/NF-kappaB-dependent pathway and the subsequent recruitment of p300...
  11. pmc Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
    Yan Ning
    Division of Medical Oncology, Sharon A Carpenter Laboratory, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
    Int J Cancer 128:2038-49. 2011
    ..Together, these findings indicate that overexpression of IL-8 promotes tumor growth, metastasis, chemoresistance and angiogenesis, implying IL-8 to be an important therapeutic target in CRC...
  12. doi Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study
    Ayalew Tefferi
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 29:1356-63. 2011
    ..This study describes the spectrum of plasma cytokine abnormalities in primary myelofibrosis (PMF) and examines their phenotypic correlates and prognostic significance...
  13. doi Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival
    Dietrich Doll
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Int J Colorectal Dis 25:573-81. 2010
    ....
  14. pmc α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8
    David A Bergin
    1Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Clin Invest 120:4236-50. 2010
    ..These results provide new insight into the mechanism underlying the effect of AAT augmentation therapy in the pulmonary disease associated with AAT deficiency...
  15. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005
    ..These findings suggest that genetic polymorphisms in IL-8, IL-10 and TNFalpha may play important roles in developing gastric cancer in the Chinese population...
  16. ncbi The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8
    Joseph E De Larco
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Cancer Res 10:4895-900. 2004
    ..Possible targets are also presented for the development of therapies to attenuate the effects of the ectopic IL-8 release by tumor cells...
  17. pmc Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer
    Sabrina Thalita Reis
    Urology Department, University of Sao Paulo Medical School, Sao Paulo, Brazil
    BMC Urol 12:18. 2012
    ..The purpose of this study was to investigate whether the expression of MMP-9, MMP-2 and its specific inhibitors, are expressed in a reproducible, specific pattern and if the profiles are related to prognosis in Bladder Cancer (BC)...
  18. ncbi Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells
    Chen Yao
    Division of Breast Surgery, Department of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Cancer 121:1949-57. 2007
    ....
  19. ncbi IL-8 and IDO expression by human gingival fibroblasts via TLRs
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Henry Dunant Road, Bangkok, Thailand
    J Immunol 178:1151-7. 2007
    ..Our results suggest an important role of HGFs not only in orchestrating the innate immune response, but also in dampening potentially harmful hyperactive inflammation in periodontal tissue...
  20. pmc Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway
    Yi Lai
    Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China
    Int J Biol Sci 7:782-91. 2011
    ....
  21. pmc Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8
    Sharmistha Bhattacharyya
    Department of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 286:11604-15. 2011
    ..These data suggest that miR-155 may play an important role in the activation of IL-8-dependent inflammation in CF...
  22. pmc LPS-induced IL-8 activation in human intestinal epithelial cells is accompanied by specific histone H3 acetylation and methylation changes
    Tiziana Angrisano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L, Califano, Facoltà di Farmacia e Facoltà di Scienze Biotecnologiche, Universita degli Studi di Napoli Federico II, Via S, Pansini 5, Naples, 80131, Italy
    BMC Microbiol 10:172. 2010
    ....
  23. doi Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis
    Emer P Reeves
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 183:1517-23. 2011
    ..Evidence that increased hypertonicity of airway secretions induced by hypertonic saline treatment alters levels of IL-8 is lacking...
  24. pmc Novel roles for hypoxia and prostaglandin E2 in the regulation of IL-8 during endometrial repair
    Jacqueline A Maybin
    University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, Scotland
    Am J Pathol 178:1245-56. 2011
    ..Progesterone withdrawal, hypoxia, and PGE(2) regulate endometrial IL-8 by acting via HIF-1 and NF-κB. Hence, progesterone withdrawal may activate two distinct pathways to initiate endometrial repair...
  25. ncbi Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 148:535-42. 2003
    ....
  26. ncbi A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells
    Hyun Ock Pae
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Shinyoung dong, Iksan Shi, Chonbug 570 749, Republic of Korea
    Endocrinology 146:2229-38. 2005
    ..Taken together, these results provide a molecular cascade showing NO-HO-1-VEGF-IL-8 sequence in human endothelial cells...
  27. pmc Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling
    Annelie Pichert
    Institute of Medical Physics and Biophysics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Glycobiology 22:134-45. 2012
    ..Our results highlight the importance of combining experimental and theoretical approaches to obtain a better understanding of the molecular recognition properties of GAG-protein systems...
  28. pmc Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis
    Henning W Zimmermann
    Department of Medicine III, University Hospital, Aachen, Germany
    PLoS ONE 6:e21381. 2011
    Interleukin-8 (IL-8, CXCL8) is a potent chemoattractant for neutrophils and contributes to acute liver inflammation...
  29. doi SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells
    Wei Lun Hwang
    Institution of Microbiology and Immunology, VGH YM Genome Research Center, National Yang Ming University, and Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Gastroenterology 141:279-91, 291.e1-5. 2011
    ..Little is known about the mechanisms that regulate the stem cell-like features of cancer cells; we investigated genes associated with stem cell-like features of colorectal cancer (CRC) cells...
  30. ncbi The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes
    C G Larsen
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21701
    Science 243:1464-6. 1989
    ..Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes...
  31. pmc Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
    Nuria de la Iglesia
    Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5870-8. 2008
    ..We also identify the chemokine interleukin 8 (IL8) as a novel target gene of STAT3 in human glioblastoma cells...
  32. ncbi MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Hematology 7:113-7. 2002
    ..05). These data indicate that hMSCs are targeted by inflammatory chemotactic agents and cytokines and that ischemic brain attracts hMSCs...
  33. ncbi Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line
    Ippei Kuwahara
    Respiratory Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Am J Physiol Lung Cell Mol Physiol 291:L407-16. 2006
    ..We conclude that NE increases IL-8 transcription through p38/NF-kappaB activation via EGFR transactivation...
  34. ncbi Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients
    Abdolreza Rezaie-Majd
    Clinic of Internal Medicine II, Department of Angiology, University of Vienna, Vienna, Austria
    Arterioscler Thromb Vasc Biol 22:1194-9. 2002
    ..The anti-inflammatory effects of statins have recently been implicated in the clinical benefit that can be obtained in the treatment of atherosclerosis. Little is known about the mechanisms by which statins counteract inflammation...
  35. pmc The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population
    M Ohyauchi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Gut 54:330-5. 2005
    ..Helicobacter pylori infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process...
  36. doi Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy
    Yoshihiro Wakabayashi
    Department of Ophthalmology, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan
    Retina 31:1951-7. 2011
    ..To investigate whether concurrent hypertension affects vitreous cytokine levels in diabetic retinopathy...
  37. pmc Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells
    Monika Riederer
    Institute of Molecular Biology and Biochemistry, Harrachgasse 21 III, Medical University Graz, 8010 Graz, Austria
    Atherosclerosis 214:338-44. 2011
    ..In the present study, the impact of EL and EL-generated LPC on interleukin-8 (IL-8) synthesis was examined in vitro in primary human aortic endothelial cells (HAEC) and in mice...
  38. doi Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain
    Chih Ho Lai
    Graduate Institute of Basic and Clinical Medical Science, School of Medicine, China Medical University, Taichung, Taiwan
    FEMS Microbiol Lett 323:155-63. 2011
    ..Our results suggest that CagA CTD-containing EPIYAs directly interact with cholesterol-rich microdomains that induce efficient IL-8 secretion in the epithelial cells...
  39. ncbi Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites
    Birgit Goger
    Institute of Pharmaceutical Chemistry, Protein Chemistry and Biophysics Group, University of Graz, Universitatsplatz 1, A 8010 Graz, Austria
    Biochemistry 41:1640-6. 2002
    ....
  40. doi Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-α and IL-8/CXCL8 mRNA: new insights into the involvement of 'alarmins'
    Heinrich Dickel
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Contact Dermatitis 63:215-22. 2010
    ..It is under discussion whether the cutaneous inflammation induced by tape stripping is a pivotal element in enhancing the allergic contact dermatitis response...
  41. pmc Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release
    Lisa B Davidson
    Department of Medicine, New Mexico Veterans Health Care System, Albuquerque, New Mexico, USA
    PLoS ONE 6:e29148. 2011
    ..abscessus colonization of abnormal lung airways escapes detection by the innate immune system...
  42. pmc Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow
    Nicole E Hastings
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 29:725-31. 2009
    ..We tested the hypothesis that IL-8 limits SMC VCAM-1 expression in response to inflammatory stimuli, either atheroprone flow or cytokine interleukin-1beta (IL-1beta) addition...
  43. pmc Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy
    Jiajia Ma
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Biol Chem 284:34600-6. 2009
    ..Consequently, knockdown of EGR-1 inhibited IL-8-mediated tumor colony formation and invasion. Thus, targeted knockdown of EGR-1 could be an effective therapeutic approach against prostate cancer...
  44. pmc Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production
    John P Fitzgerald
    Department of Urology, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 7:e30712. 2012
    ..AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status and a role for AMPK in the regulation of cell inflammatory processes has recently been demonstrated...
  45. ncbi Activation of NF-kappaB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades
    Guntram A Grassl
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitatsklinikum Tubingen, D 72076 Tubingen, Germany
    Cell Microbiol 5:957-71. 2003
    ..Our data identify Rac1 as a key intermediate in invasin-triggered IL-8 synthesis and demonstrate that maximum IL-8 induction involves several MAP kinase cascades...
  46. doi Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
    Ying Liao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Virology 420:106-16. 2011
    ....
  47. ncbi Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level
    Irina V Nesmelova
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:4948-58. 2005
    ..This concept, in turn, has implications for designing chemokine/cytokine variants with modified biological properties...
  48. ncbi Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
    Ina H Benoy
    Translational Cancer Research Group Antwerp, University of Antwerp, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 10:7157-62. 2004
    ..The predictive value of serum IL-8 for the presence of occult metastatic tumor cells in bone marrow aspirates was evaluated in patients with operable and metastatic breast cancer...
  49. doi Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells
    Stefania Gessi
    Chair of Pharmacology, Faculty of Medicine, University of Ferrara, Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 30:90-7. 2010
    ..As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs...
  50. ncbi Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550 Japan
    Cancer Epidemiol Biomarkers Prev 14:2487-93. 2005
    ..In conclusion, we showed that the IL-8 -251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer...
  51. doi Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis
    Geun Young Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    J Immunol 184:3946-54. 2010
    ....
  52. doi Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma
    Bing Liao
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Surg Oncol 102:844-51. 2010
    ..We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival of nasopharyngeal carcinoma (NPC), and determine whether MIF is a valuable prognostic predictor for NPC patients...
  53. pmc Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
    William M Merritt
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:359-72. 2008
    ..Interleukin-8 (IL-8) is a proangiogenic cytokine that is overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 in ovarian carcinoma using human samples and orthotopic mouse models...
  54. pmc HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA
    Ankit Shah
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, Kansas City, MO 64108, USA
    J Neuroinflammation 7:96. 2010
    ..In this study, we sought to address whether HIV-1gp120 could affect IL-8 expression in astrocytes and whether the NF-κB pathway is involved in this phenomenon...
  55. doi An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway
    Gaku Tsuji
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Dermatol Sci 62:42-9. 2011
    ..Although BaP has been shown to exert its biological effects via the aryl hydrocarbon receptor (AhR) signaling pathway, the mechanism of its inflammatory effects on skin remains unanswered...
  56. doi Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells
    Lu Zhang
    Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China
    J Cell Physiol 226:1694-701. 2011
    ..PC-PLC might be a potential target for therapy in inflammation associated-diseases such as atherosclerosis...
  57. ncbi Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway
    Aye Aye Khine
    Department of Anaesthesia, St Michael s Hospital, Rm 7 007, Queen Wing, 30 Bond St, Toronto, Ontario M5B 1W8, Canada
    Blood 107:2936-42. 2006
    ..Transfection of lung epithelial cells with antisense oligonucleotides targeting specific purinergic P2Y receptors revealed that the P2Y6 (ligand of UDP) signaling pathway plays a predominant role in mediating HNP-induced IL-8 production...
  58. ncbi Interleukin-8 as a macrophage-derived mediator of angiogenesis
    A E Koch
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611
    Science 258:1798-801. 1992
    ..These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair...
  59. pmc Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8
    Reinhold J Medina
    Centre for Vision and Vascular Science, School of Medicine, Dentistry, and Biomedical Science, Queen s University Belfast, Belfast, UK
    Mol Med 17:1045-55. 2011
    ..We also show, for the first time, the true identity of these cells as alternative M2 macrophages with proangiogenic, antiinflammatory and pro-tissue-repair properties...
  60. doi Interleukin 8 and cardiovascular disease
    Stavros Apostolakis
    Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, 71409 Heraklion, Crete, Greece
    Cardiovasc Res 84:353-60. 2009
    ..In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed...
  61. ncbi The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
    Emmanuelle Adam
    Department of Applied Genetics, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, B 6041 Gosselies, Belgium
    J Biol Chem 281:6910-23. 2006
    ..We conclude that Der p 1 (but not Der p 3)-induced IL-8 production in A549 epithelial cells is independent of PAR(2) activation...
  62. ncbi Three-dimensional structure of interleukin 8 in solution
    G M Clore
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Biochemistry 29:1689-96. 1990
    The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-dynamical simulated annealing calculations...
  63. doi Cytokines in bronchoalveolar lavage fluid and serum of lung cancer patients during radiotherapy - Association of interleukin-8 and VEGF with survival
    Marika Crohns
    Department of Oncology, University of Tampere, Tampereen yliopisto, Finland
    Cytokine 50:30-6. 2010
    ..The increase of BAL fluid IL-6 during RT might be attributed to enhanced RT-related oxidative stress or increased cell death. Serum and BAL fluid IL-8 and serum VEGF might have a prognostic role in survival of lung cancer...
  64. ncbi Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein
    Kimberly A Walton
    Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:29661-6. 2003
    ..Therefore, these studies suggest that ox-PAPC may initially bind to a 37-kDa GPI-anchored protein, which interacts with TLR4 to induce IL-8 transcription...
  65. ncbi Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
    Owen A Ross
    Department of Geriatric Medicine, Belfast, Ireland
    Hum Immunol 65:340-6. 2004
    ....
  66. doi Modulation of cystic fibrosis lung disease by variants in interleukin-8
    A D Hillian
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4948, USA
    Genes Immun 9:501-8. 2008
    ..01< or =R2< or =0.49). Studies revealed differential expression between the IL8 promoter variant alleles (P<0.001). These results suggest that IL8 variants modify CF lung disease severity and have functional consequences...
  67. ncbi IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules
    Kumiko Isse
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 27:672-80. 2007
    ..Recently, biliary epithelial cells have been shown to secrete cytokines and chemokines and to express components of the mucosal immune system such as Toll-like receptors...
  68. pmc Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways
    Anastasia M Torok
    University of Virginia Health System, P O Box 800734, Charlottesville, VA 22908 0734, USA
    Infect Immun 73:1523-31. 2005
    ..pylori induces IL-8 secretion through a dual mechanism that includes a TLR2/5-independent component involving the activities of JNK and ERK and a TLR2/5-dependent component that requires p38 activity...
  69. ncbi Prognostic value of serum level of interleukin-6 and interleukin-8 in metastatic breast cancer patients
    Olal I Ahmed
    Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Egypt J Immunol 13:61-8. 2006
    ..Thus, it could be concluded that serum level of IL-6 and IL-8 are useful prognostic factors in metastatic breast cancer patients...
  70. pmc Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α
    Suneesh Kumar Pachathundikandi
    Institute for Medical Microbiology, Otto von Guericke University, Magdeburg, Germany
    PLoS ONE 6:e19614. 2011
    ..pylori-induced expression of TLR-2 and TLR-5 can qualitatively shift cagPAI-dependent to cagPAI-independent pro-inflammatory signalling pathways with possible impact on the outcome of H. pylori-associated diseases...
  71. pmc Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway
    Viviane Balloy
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris 75015, France
    J Biol Chem 283:30513-21. 2008
    ..fumigatus, one that is MyD88-dependent and another that is My88-independent and involved in IL-8 synthesis...
  72. doi IL-1beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H. pylori eradication in gastroduodenal phenotypes
    Young Woon Chang
    Department of Gastroenterology, Kyung Hee University College of Medicine, Seoul, Korea
    Scand J Gastroenterol 43:1184-93. 2008
    ..pylori according to IL-1B genotypes and benign gastroduodenal phenotypes in a Korean population...
  73. ncbi IL-8 and its CXCR1 and CXCR2 receptors participate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis
    Sharareh Emadi
    Institut National de la Sante et de la Recherche Medicale, Unit 602, André Lwoff Institute, Paul Brousse Hospital, Villejuif, France
    Blood 105:464-73. 2005
    ..The various biologic activities of interleukin 8 (IL-8) in hematopoietic progenitor proliferation and mobilization as well as in neoangiogenesis prompted us to ..
  74. pmc The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment
    Charlotte Rolny
    Institute for Cancer Research and Treatment IRCC, University of Turin, School of Medicine, 10060 Candiolo, Italy
    J Exp Med 205:1155-71. 2008
    ..In conclusion, we report that SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion and recruitment of macrophages coupled to the suppression of tumor growth...
  75. pmc The 3'-untranslated region of human interleukin-8 mRNA suppresses IL-8 gene expression
    Y Yu
    Institute of Parasitology of McGill University, Ste Anne de Bellevue, Quebec, Canada
    Immunology 102:498-505. 2001
    ..This study gives new insights in unravelling the molecular mechanisms involved in the post-transcriptional regulation of the IL-8 gene...
  76. pmc Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity through induction of interleukin-8 in nasopharyngeal carcinoma cells
    Meichi Hsu
    Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
    J Virol 82:3679-88. 2008
    ..Since IL-8 may contribute to not only leukocyte infiltration but also multiple oncogenic processes, the present study provides a potential link between EBV lytic infection and pathogenesis of NPC...
  77. doi Phospholipase C-β3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells
    Valentino Bezzerri
    Laboratory of Molecular Pathology, University Hospital of Verona, 37126 Verona, Italy
    J Immunol 186:4946-58. 2011
    ....
  78. ncbi Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease
    Umut Arinir
    Deparment of Internal Medicine III, Pneumology, Allergology and Sleep Medicine, University Hospital Bergmannsheil, Bochum, Germany
    Electrophoresis 26:2888-91. 2005
    ..Although IL-8 plays an important role in the chemotaxis of inflammatory cells, the polymorphisms investigated here do not seem to be involved in the genetic predisposition to COPD...
  79. ncbi Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis
    Andrea Heinzmann
    University Children s Hospital, University of Freiburg, 79106 Freiburg, Germany
    J Allergy Clin Immunol 114:671-6. 2004
    ..Furthermore, epidemiologic studies have demonstrated an increased risk for the development of asthma after RSV bronchiolitis, and a common genetic background for the 2 diseases is currently being discussed...
  80. ncbi Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Causes Control 17:117-25. 2006
    ..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals...
  81. ncbi Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2
    Jan Heidemann
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    J Biol Chem 278:8508-15. 2003
    ..The chemokine interleukin 8 (IL-8; CXCL8) exerts potent angiogenic properties on endothelial cells through interaction with its cognate ..
  82. ncbi Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia
    Huangui Xiong
    The Laboratory of Neurophysiology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 71:600-7. 2003
    ..The induction of IL-8 in HAD, its inhibition of LTP, and the expression of its receptor, CXCR2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with HAD...
  83. ncbi [The concentration and expression of IL-4, IL-5, IL-6, IL-8 in human nasal polyps tissues]
    Jianxin Yue
    Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 20:484-6. 2006
    ..To study the concentration and expression of IL-4, IL-5, IL-6, IL-8 in human nasal polyps tissues, and to explore the relationship between cytokines and the formative mechanism of nasal polyps...
  84. ncbi Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    Anke Sparmann
    Graduate Program in Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Cancer Cell 6:447-58. 2004
    ..Collectively, our data identify a novel mechanism by which the Ras oncogene can elicit a stromal response that fosters cancer progression...
  85. ncbi Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    Michael Yeh
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 279:30175-81. 2004
    ..induce endothelial cells to synthesize chemotactic factors, such as interleukin 8 (IL-8)...
  86. ncbi The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor
    S K Ahuja
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:20545-50. 1996
    ..These findings have important implications for developing novel neutrophil-specific anti-inflammatory drugs directed against the CXC chemokine signaling system...
  87. pmc Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines
    T Yoshimura
    Laboratory of Immunobiology, National Cancer Institute, Frederick, MD 21701
    Proc Natl Acad Sci U S A 84:9233-7. 1987
    ..Potency and efficacy are comparable to that of fMet-Leu-Phe, which is often used as a reference. In contrast to many attractants, the protein was not chemotactic for human monocytes...
  88. pmc A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
    ..Our results provide new insights into the negative feedback regulation of TLR-5 signalling that maintains the innate immune system in the gut...
  89. ncbi Induction of interleukin-8 (CXCL-8) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells: Impact of CXCL-8 as an autocrine growth factor
    Hidenobu Kamohara
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Oncol 31:627-32. 2007
    ..These results suggest that CXCL-8 plays a pivotal role in progression of pancreatic cancer, and its expression is influenced by inflammatory cytokines in pancreatic tumor microenvironment...
  90. ncbi Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure
    Iveta Dobreva
    Department of Cellular Biology and Morphology, Faculty of Biology and Medicine, Lausanne University, 1005 Lausanne, Switzerland
    J Biol Chem 281:199-205. 2006
    ..Regulation of fibroblast shape and migration by lipoproteins may be relevant to atherosclerosis that is characterized by increased LDL cholesterol levels, IL-8 production, and extensive remodeling of the vessel wall...
  91. ncbi Induction of a CXCL8 binding site on endothelial syndecan-3 in rheumatoid synovium
    Angela M Patterson
    University of Newcastle upon Tyne, UK
    Arthritis Rheum 52:2331-42. 2005
    To identify and characterize which endothelial heparan sulfate proteoglycans (HSPGs) bind the chemokine CXCL8 (interleukin-8) in human rheumatoid arthritis (RA) and nonrheumatoid synovia.
  92. doi Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter
    Alison E John
    Centre for Respiratory Research and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom
    J Immunol 183:4682-92. 2009
    b>CXCL8 is a neutrophil and mast cell chemoattractant that is involved in regulating inflammatory cell influx in asthma...
  93. ncbi Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer
    Shinako Araki
    Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Cancer Res 67:6854-62. 2007
    ..Therefore, IL-8 is a molecular determinant of androgen-independent prostate cancer growth and progression...
  94. doi Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas--implication for clinical evaluation of cancer patient
    Malgorzata Krzystek-Korpacka
    Department of Medical Biochemistry, Silesian Piasts University of Medicine, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Cytokine 41:232-9. 2008
    ..Yet, the detection rates were not satisfactory enough to allow for the recommendation of IL-8 determination as an adjunct to the clinical evaluation of lymph node involvement in ESCC patients...
  95. pmc Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle
    Ute Oltmanns
    Experimental Studies National Heart and Lung Institute, Imperial College, London SW36LY, UK
    Respir Res 6:74. 2005
    ..Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. We investigated whether cigarette smoke could directly induce the release of chemokines from HASMC...
  96. pmc CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells
    Neeraj Vij
    Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, 200 N Wolfe St, Baltimore, MD 21287, USA
    Am J Respir Cell Mol Biol 38:176-84. 2008
    ..We confirmed the regulation of IL-8 promoter by CHOP in CF cells using the IL-8 reporter assay. We conclude that PGE-2 stimulates IL-8 production through the CHOP transcription factor in CF cells...
  97. pmc CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex
    Daniel Martin
    Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 4340, USA
    J Biol Chem 284:6038-42. 2009
    ..How this intracellular pool of VEGF is regulated is still not understood. Here, we found that CXCL8/IL8, a potent proangiogenic and inflammatory chemokine, up-regulates VEGF mRNA and protein levels in endothelial ..
  98. ncbi The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population
    Paulo Canedo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Cancer Prev 17:28-32. 2008
    ..In conclusion our results indicate that although the IL8-251 polymorphism might be a relevant host susceptibility factor for gastric carcinoma development, this association is likely to be ethnic-specific...
  99. ncbi Association of interleukin-8 (IL-8 or CXCL8) -251T/A and CXCR2 +1208C/T gene polymorphisms with breast cancer
    E Kamali-Sarvestani
    Department of Immunology, Shiraz Medical School, Shiraz University of Medical School, Shiraz Iran
    Neoplasma 54:484-9. 2007
    ..6% and 7.1%, respectively; p=0.07). In conclusion, IL-8 -251T/A polymorphism is associated with development of invasive ductal carcinoma type of breast cancer while CXCR2 +1208C/T polymorphism may affect the disease progression...
  100. ncbi Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients
    Malgorzata Krzystek-Korpacka
    Department of Medical Biochemistry, Wroclaw Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Clin Biochem 40:1353-60. 2007
    ..Proinflammatory cytokines are involved in cancer-related weight loss, but the involvement of VEGF-A, VEGF-C, IL-8 and midkine in gastroesophageal cancer patients remains unknown...
  101. ncbi Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir, Tunisia
    Hum Immunol 68:761-9. 2007
    ..Our findings suggest that the IL-8 promoter polymorphism is associated with increased nasopharyngeal carcinoma risk, particularly in males, as well as disease progress, supporting our hypothesis for IL-8 involvement in NPC pathogenesis...

Research Grants70

  1. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Silvia S Pierangeli; Fiscal Year: 2010
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  2. The role of polyamine oxidase in antitumor drug response
    ROBERT CASERO; Fiscal Year: 2009
    ..A better understanding of the role of SMO in inflammation-induced cancers should aid in treatment strategies to prevent cancer. ..
  3. The role of polyamine oxidase in antitumor drug response
    Robert A Casero; Fiscal Year: 2010
    ..A better understanding of the role of SMO in inflammation-induced cancers should aid in treatment strategies to prevent cancer. ..
  4. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    ..The proposed study fulfills the scope of the NIAID small research grants program as a small, self-contained research project requiring minimal funding for a limited time. ..
  5. VEGF AND RELATED PROTEINS IN AIDS RELATED KAPOSI SARCOMA
    Parkash Gill; Fiscal Year: 2003
    ..abstract_text> ..
  6. Regulation of Chemokine Mediated Leukocyte Functions
    Micheler Ricardo Richardson; Fiscal Year: 2010
    ..The Interleukin-8 (IL-8/CXCL8) receptors (CXCR1 and CXCR2) bind CXCL8 with similar affinity to initiate leukocyte chemotaxis, but only CXCR1 ..
  7. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona Santos; Fiscal Year: 2010
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  8. Genetic susceptibility to gastric cancer in Latin America
    Eduardo Tarazona Santos; Fiscal Year: 2007
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  9. RECEPTOR INTERACTION WITH GTP REGULATORY PROTEINS
    Gary Johnson; Fiscal Year: 2007
    ..Cumulatively, the studies will define new strategies for the development of pharmacological ligandsto regulate subsets of receptor functions that will have much more selective effects on target cells and tissues. ..
  10. IL8 and GATA3-mediated Pathways in Asthma Exacerbations
    Fernando Martinez; Fiscal Year: 2007
    ..End of Abstract) ..
  11. Role of MU5AC Mucins in Airway Disease
    Mary Rose; Fiscal Year: 2003
    ..abstract_text> ..
  12. Role of MU5AC Mucins in Airway Disease
    Mary Rose; Fiscal Year: 2006
    ..abstract_text> ..
  13. STAT3 Regulation of Glioblastoma Pathogenesis
    Azad Bonni; Fiscal Year: 2010
    ....
  14. Regulation of Proinflammatory Signaling Pathways by CFTR
    Harvey Pollard; Fiscal Year: 2004
    ..The impact of this research will be to identify novel pathways by which CFTR affects the ability of lung epithelial cells to respond to bacterial assault. ..
  15. Role of chemokine monomer-dimer equilibrium in innate immunity and inflammation
    Krishna Rajarathnam; Fiscal Year: 2009
    The chemokine CXCL8 (also known as interleukin-8) plays a key role in innate immunity and inflammation by recruiting neutrophils from the bloodstream to tissue damaged by such insults as bacterial infection...
  16. Role of chemokine monomer-dimer equilibrium in innate immunity and inflammation
    Krishna Rajarathnam; Fiscal Year: 2010
    The chemokine CXCL8 (also known as interleukin-8) plays a key role in innate immunity and inflammation by recruiting neutrophils from the bloodstream to tissue damaged by such insults as bacterial infection...
  17. Role of chemokine monomer-dimer equilibrium in innate immunity and inflammation
    Krishna Rajarathnam; Fiscal Year: 2007
    The chemokine CXCL8 (also known as interleukin-8) plays a key role in innate immunity and inflammation by recruiting neutrophils from the bloodstream to tissue damaged by such insults as bacterial infection...
  18. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
    ..In addition, results from our pilot studies suggest that quercetin inhibits interleukin (IL)-8/CXCL8 expression from airway epithelial cells and human monocyte- derived macrophages in response to P...
  19. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..In addition, results from our pilot studies suggest that quercetin inhibits interleukin (IL)-8/CXCL8 expression from airway epithelial cells and human monocyte- derived macrophages in response to P...
  20. HIV/STI Prevention among Alcohol-Abusing Women in Mongolia
    Susan Witte; Fiscal Year: 2007
    ..Women clientele of the National AIDS Foundation (NAF) program in Ulaanbaatar, Mongolia will be recruited...