IL-4

Summary

Gene Symbol: IL-4
Description: interleukin 4
Alias: BCGF-1, BCGF1, BSF-1, BSF1, IL-4, B cell growth factor 1, B_cell stimulatory factor 1, binetrakin, interleukin-4, lymphocyte stimulatory factor 1, pitrakinra
Species: human

Top Publications

  1. ncbi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
  2. ncbi A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood
    Michael Kabesch
    University Children s Hospital of Munich, Germany
    J Allergy Clin Immunol 112:893-8. 2003
  3. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
  4. ncbi Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Obstet Gynecol 104:293-300. 2004
  5. ncbi A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
  6. ncbi IL-4-mediated fine tuning of IL-12p70 production by human DC
    Emmanuella Guenova
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 38:3138-49. 2008
  7. ncbi Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort
    S Black
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London NW1 2HE, UK
    Allergy 64:1172-8. 2009
  8. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
  9. ncbi Association between IL-4 genotype and IL-4 production in the Japanese population
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Genes Immun 3:107-9. 2002
  10. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003

Research Grants

  1. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2011
  2. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2007
  3. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2010
  4. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2011
  5. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2009
  6. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
  8. Targeted Toxin for Brain Cancer Gene Therapy
    Maria Castro; Fiscal Year: 2007
  9. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian Hines; Fiscal Year: 2007
  10. Gene Regulation by IL-4 and IL-13 in Airway Cells
    June Lee; Fiscal Year: 2004

Detail Information

Publications188 found, 100 shown here

  1. ncbi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
    ..The aim of the present study is to elucidate whether the single nucleotide polymorphisms (SNP) and the interaction of variants in the 5 genes are associated with the development of GD and Graves' ophthalmopathy (GO)...
  2. ncbi A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood
    Michael Kabesch
    University Children s Hospital of Munich, Germany
    J Allergy Clin Immunol 112:893-8. 2003
    ..Polymorphism C-589T was reported to influence total serum IgE levels and bronchial hyperresponsiveness. However, no study has investigated the putative existence of further SNPs in exons, introns, and flanking regions of the IL4 gene...
  3. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  4. ncbi Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Obstet Gynecol 104:293-300. 2004
    ..Differences in allelic carriage of immune system-related genes among white, black, and Hispanic pregnant women living in New York City and Boston were evaluated...
  5. ncbi A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
    ..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders...
  6. ncbi IL-4-mediated fine tuning of IL-12p70 production by human DC
    Emmanuella Guenova
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 38:3138-49. 2008
    ..Thus, we demonstrate that the Th2 cell cytokine IL-4 decisively determines the phenotype of ongoing immune responses by orchestrating the functional phenotype of newly immigrating DC precursors...
  7. ncbi Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort
    S Black
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London NW1 2HE, UK
    Allergy 64:1172-8. 2009
    ....
  8. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
    ..An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production...
  9. ncbi Association between IL-4 genotype and IL-4 production in the Japanese population
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Genes Immun 3:107-9. 2002
    ..These results make it likely that IL-4 genotype could influence the type of immune response...
  10. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  11. ncbi Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain
    Jin Li Zhang
    Theodor Boveri Institut für Biowissenschaften, Biozentrum, Physiologische Chemie II, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Biochem Biophys Res Commun 300:291-6. 2003
    ..These results open the way to understand the molecular recognition mechanism in the IL-21 receptor system and also the promiscuous binding properties of gamma(c)...
  12. ncbi Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma
    Kittipong Maneechotesuwan
    Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Allergy Clin Immunol 123:239-48. 2009
    ..Indoleamine 2, 3-dioxygenase (IDO), a tryptophan-degrading enzyme in dendritic cells (DCs), mediates an immunosuppressive effect on activated T lymphocytes. However, little is known about the effect of Der p 1 on IDO in human DCs...
  13. ncbi Regulation of eotaxin-3/CCL26 expression in human monocytic cells
    Victoria E L Stubbs
    Department of Physiology, University of Calgary, Alberta, Canada
    Immunology 130:74-82. 2010
    ..These data show that IL-4 and pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IFN-gamma regulate CCL26 synthesis in human monocytic cells, which may be important in regulating monocyte inflammatory responses...
  14. ncbi IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway
    John F Grehan
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 175:1903-10. 2005
    ..We conclude that IL-4 and IL-13 can induce protection of porcine EC against killing by apoptosis and human complement through activation of the PI3K/Akt signaling pathway...
  15. ncbi Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels
    I Suzuki
    First Department of Medicine, School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Clin Exp Allergy 30:1746-9. 2000
    ..05). The data suggest that IL-4 promoter C+33T polymorphism may be one of the genetic polymorphisms that explain genetic linkage or association between elevated total serum IgE levels and markers on chromosome 5q...
  16. ncbi Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 113:489-95. 2004
    ..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors...
  17. ncbi Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa
    G Luoni
    Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 2:411-4. 2001
    ..These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting...
  18. ncbi Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population
    B Beghe
    Divisions of Human Genetics Infection, Inflammation and Repair, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:1111-7. 2003
    ..IL-4 by binding to its receptor (IL-4R) is essential for the development of airway inflammation present in asthma, through the induction of IgE synthesis in B cells and differentiation of T cells to a Th2 phenotype...
  19. ncbi Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma
    Tianpen Cui
    Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R of China
    Clin Chem Lab Med 41:888-92. 2003
    ..16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese...
  20. ncbi The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Mol Biol 315:399-407. 2002
    ..These results show that the high-affinity IL-4/IL4-BP contact is constituted by two independent binding units, each containing a central polar or charged side-chain surrounded by hydrophobic groups (avocado cluster)...
  21. ncbi Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis
    Stephane Genevay
    University Hospital of Geneva, Switzerland
    Arthritis Rheum 47:303-9. 2002
    ..To perform a genetic association study using markers in the interleukin-1 (IL-1) gene cluster and the IL-4/IL-4 receptor system genes, seeking evidence for involvement in the onset or the erosive outcome of rheumatoid arthritis (RA)...
  22. ncbi Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population
    G P Aithal
    Centre for Liver Research, Medical School, University of Newcastle upon Tyne, UK
    Genes Immun 2:44-7. 2001
    ..005). Association with alleles resulting in high IL-4 transcription and enhanced signalling activity suggests that IL-4 may have a role in the pathogenesis of Crohn's disease...
  23. ncbi Influence of patient and donor cytokine genotypes on renal allograft rejection: evidence from a single centre study
    K L Poole
    Histrocompatibility and Immunogenetics Laboratory, Southampton Unitversity Hospitals, UK
    Transpl Immunol 8:259-65. 2001
    ..However, due to conflicting results from this and other studies, a multi-centre collaborative study may be required to determine whether cytokine genotypes are significant, independent predictors of renal allograft rejection...
  24. ncbi Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells
    Soo Ok Lee
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 68:85-91. 2008
    ..In this study, the role of IL-4 in promoting the growth of androgen-independent prostate cancer cells was examined...
  25. ncbi The duplicitous effects of interleukin 4 on tumour immunity: how can the same cytokine improve or impair control of tumour growth?
    S Olver
    Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Tissue Antigens 69:293-8. 2007
    Successful tumour immunity relies on innate and adaptive immune responses, with cytokines like interleukin 4 (IL-4) known to influence tumour clearance in both positive and negative ways...
  26. ncbi IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway
    Gregory B Carey
    Program in Oncology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Res 17:942-55. 2007
    ..These results suggest that the IL-4 receptor activates several signaling pathways, with the Akt pathway playing a major role in suppression of the apoptotic program activated by anti-IgM...
  27. ncbi Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis
    Zhiguang Li
    National Laboratory of Biomacromolecules, Chinese Academy of Sciences University of Tokyo Joint Laboratory of Structural Virology and Immunology, Graduate School of Chinese Academy of Sciences, Institute of Biophysics, Beijing, China
    Cancer Res 68:8687-94. 2008
    ..These findings were helpful to understand the long clinical observation and revealed that endogenous IL-4, the product of host immune response, can be used by tumor cells to facilitate their growth...
  28. ncbi Genetic association of interleukin-4, interleukin-10, and transforming growth factor-beta gene polymorphism with allograft function in renal transplant patients
    M Amirzargar
    Kidney Transplant Division, Ekbatan Hospital, Hamadan University of Medical Sciences, Tehran, Iran
    Transplant Proc 39:954-7. 2007
    ..TGF-beta codon 10 T allele was 39% in RE, 35% in SGF, and 53% in control group. In conclusion, this study suggested that some cytokine gene alleles reflected SGF among kidney transplant recipients...
  29. ncbi Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma
    Natalie C Battle
    University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Am J Respir Crit Care Med 175:881-7. 2007
    ..Furthermore, interaction between these genes has been shown to affect asthma in white and Chinese populations...
  30. ncbi Impact of the IL-4 -590 C/T transition on the levels of Plasmodium falciparum specific IgE, IgG, IgG subclasses and total IgE in two sympatric ethnic groups living in Mali
    Manijeh Vafa
    Department of Immunology, Stockholm University, S 106 91 Stockholm, Sweden
    Microbes Infect 11:779-84. 2009
    ..Taken together, these data indicate that the impact of IL-4 -590 variants on antibody levels may vary in different ethnic populations, and that this might affect the Ig-class and subclass distributions...
  31. ncbi Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma
    Tianpen Cui
    Immunology Laboratory, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
    J Huazhong Univ Sci Technolog Med Sci 23:134-7. 2003
    ..127, respectively; P < 0.01)] and was correlated with the increased plasma total IgE. These data suggested that the IL-4R alpha chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China...
  32. ncbi Allelic polymorphism of cytokine genes during pulmonary tuberculosis
    I O Naslednikova
    Department of Pathophysiology, Department of Phthisiology and Pulmonology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia
    Bull Exp Biol Med 148:175-80. 2009
    ....
  33. ncbi Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels
    Teri Roberts
    Molecular Biology and Human Genetics, Department of Biomedical Sciences, University of Stellenbosch, Cape Town, 7505, South Africa
    J Infect Dis 195:870-8. 2007
    ..Together, these results suggest that immunosuppression seen after mycobacterial stimulation in case patients with active TB is associated with naturally occurring regulatory T cells...
  34. ncbi Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions
    O Prokopchuk
    Department of Visceral and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, 89075 Ulm, Germany
    Br J Cancer 92:921-8. 2005
    ....
  35. ncbi Association between cord blood IgE and genetic polymorphisms of interleukin-4, the beta-subunit of the high-affinity receptor for IgE, lymphotoxin-alpha, and tumor necrosis factor-alpha
    Hui Ju Wen
    Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan
    Pediatr Allergy Immunol 17:489-94. 2006
    ..Our finding suggested a significant association of cbIgE with genetic polymorphism of IL-4 -590C/T, but not with the genotypes of FcepsilonRI-beta, LT-alpha, and TNF-alpha...
  36. ncbi Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells
    Nicola M Heller
    Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 31:573-82. 2004
    ..These observations have important implications for the regulation of epithelial cell activation by the balance of Th1/Th2-type cytokines in the airways in allergic disease...
  37. ncbi IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis
    Ji Young Jang
    Department of Biological Science and Institute for Basic Science, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Cell Immunol 241:14-25. 2006
    ..In contrast, siRNA knock-out of ANT3 expression induced T cell apoptosis and blocked the IL-4-mediated cell survival. Together these results suggest that ANT3 has a potential role in Th cell survival and immune cell homeostasis...
  38. ncbi Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression
    L Walch
    UMR7131 CNRS Université Pierre et Marie Curie Paris 6, Hopital Broussais, 102 rue Didot, 75014 Paris, France
    Atherosclerosis 187:285-91. 2006
    ..Although considered as an anti-inflammatory cytokine, interleukin-4 (IL-4) has been shown to be pro-atherogenic in mice models of atherosclerosis...
  39. ncbi The -590 IL-4 promoter polymorphism in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, ul Powst Wlkp 72, Poland
    Rheumatol Int 26:48-51. 2005
    ..We suggest that the IL-4 -590 promoter polymorphism may be a genetic risk factor for RA severity...
  40. ncbi IL4-589C/T polymorphism and IgE levels in severe malaria
    Federica Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, Rome, Italy
    Acta Trop 90:205-9. 2004
    ..These results raise the possibility that there is a relationship between susceptibility to severe malaria, IgE production and genetic variation in the IL4 region, which merits further investigation in other epidemiological settings...
  41. ncbi P110delta, a novel phosphoinositide 3-kinase in leukocytes
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, United Kingdom
    Proc Natl Acad Sci U S A 94:4330-5. 1997
    ..Possible selective functions of p110delta in white blood cells are discussed...
  42. ncbi IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins
    Concetta Conticello
    Department of Experimental Oncology, Mediterranean Institute of Oncology, Catania, Italy
    J Immunol 172:5467-77. 2004
    ..These findings may provide useful information for the development of therapeutic strategies aimed at restoring the functionality of apoptotic pathways in tumor cells...
  43. ncbi Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  44. ncbi Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface
    T Hage
    Institut für Physiologische Chemie II, Theodor Boveri Institut für Biowissen Schaften Biozentrum, Universitat Wurzburg, Germany
    Cell 97:271-81. 1999
    ..Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided...
  45. ncbi IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21(Waf1), cyclin D1, and cyclin E expression
    Jinkoo Kim
    Vascular System Research Center, Kangwon National University, Chunchon 200 701, Korea
    Mol Cells 16:92-6. 2003
    ..These results show that IL-4 inhibits endothelial cell growth by altering the expression of cell cycle regulatory molecules...
  46. ncbi Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma
    S G Lee
    Asan Institute for Life Sciences, University of Ulsan, Seoul, Korea
    Clin Exp Allergy 34:1202-8. 2004
    ..Interleukin-4 receptor alpha (IL-4Ralpha), which binds IL-4 and IL-13, is involved in signal transduction of those cytokines that lead to IgE production, and is also a key functional component of the Th2 lymphocyte phenotype...
  47. ncbi Interferon gamma (IFNgamma) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis
    M Vidyarani
    Tuberculosis Research Centre ICMR, Chennai, India
    Indian J Med Res 124:403-10. 2006
    ..The aim of our study was to find out whether Interferon gamma +874A and IL-4 -590T polymorphisms were associated with susceptibility to pulmonary tuberculosis as well as the level of IFNgamma and IL-4 in south Indian population...
  48. ncbi Cytokines and chronic rejection: a study in kidney transplant long-term survivors
    Mariafederica Uboldi de Capei
    Genetics Institute, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Piemonte, Italy
    Transplantation 77:548-52. 2004
    ....
  49. ncbi Human interleukin 4. The solution structure of a four-helix bundle protein
    L J Smith
    Inorganic Chemistry Laboratory, University of Oxford, England
    J Mol Biol 224:899-904. 1992
    ..m.r.) techniques have been used to determine the solution structure of human interleukin 4, a four-helix bundle protein...
  50. ncbi Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children
    B A Gyan
    Immunology Unit, Noguchi Memorial Institute for Medical Research, Ghana
    Clin Exp Immunol 138:145-50. 2004
    ..Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria...
  51. ncbi Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population
    J Javor
    Department of Immunology, School of Medicine, Comenius University, Saskinova 4, 811 08 Bratislava, Slovakia
    Int J Immunogenet 34:273-80. 2007
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases...
  52. ncbi Relative levels of IL4 and IFN-gamma in complicated malaria: association with IL4 polymorphism and peripheral parasitemia
    Piyatida Tangteerawatana
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Acta Trop 101:258-65. 2007
    ..283, p=0.046). These results suggest that the IL4-590 C/T polymorphism may play a role in the balance between IL4 and IFN-gamma, as well as in the control of parasitemia, which in turn may alter the severity of malaria...
  53. ncbi Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos
    Teodorica L Bugawan
    Roche Molecular Systems, Alameda, CA 94501, USA
    Am J Hum Genet 72:1505-14. 2003
    ..Our data suggest that the risk for T1D is determined, in part, by polymorphisms within the IL4R locus, including promoter and coding-sequence variants, and by specific combinations of genotypes at the IL4R and the IL4 and IL13 loci...
  54. ncbi Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease
    Rama Devi Mittal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India
    Immunogenetics 59:159-65. 2007
    ..Further, combined analysis implicated a higher risk in ESRD patients with low IL-4 and high IL-6 producing genotypes. This study provided the basis for defined anti-inflammatory approaches to limit renal disease progression...
  55. ncbi IL-4 receptor alpha chain genetic polymorphism and total IgE levels in the English population: two-locus haplotypes are more informative than individual SNPs
    N Bottini
    Experimental Medicine Unit, University of Wales Swansea, UK
    Clin Genet 61:288-92. 2002
    ..With regard to individual SNPs (50 478 and 551), no significant association has been observed with IgE levels or with asthma, thus confirming the higher informative value of the haplotype analysis as compared to separate study on SNPs...
  56. ncbi Crystal structure of recombinant human interleukin-4
    M R Walter
    Department of Pathology, University of Alabama at Birmingham 35294
    J Biol Chem 267:20371-6. 1992
    ..Both the tertiary and secondary structures of rhuIL-4 are similar to those of human granulocyte-macrophage colony-stimulating factor. Critical regions for receptor binding are proposed...
  57. ncbi Crystal structure of human recombinant interleukin-4 at 2.25 A resolution
    A Wlodawer
    Macromolucar Structure Laboratory, NCI Fredrick Cancer Research and Development Center, MD 21702
    FEBS Lett 309:59-64. 1992
    ..This may have identified regions which are not only important to maintain structure, but could also play a role in receptor binding...
  58. ncbi The interleukin-4 site-2 epitope determining binding of the common receptor gamma chain
    F Letzelter
    Theodor Boveri Institut für Biowissenschaften Biozentrum der Universität, Physiologische Chemie II, Wurzburg, Germany
    Eur J Biochem 257:11-20. 1998
    ..This site-2 affinity seems to be sufficient, however, to promote, in a second step, a productive association of gamma(c) to an IL-4/alpha chain complex in the membrane...
  59. ncbi Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy
    T Muller
    Theodor Boveri Institut für Biowissenschaften Biozentrum Universität Würzburg, Germany
    J Mol Biol 237:423-36. 1994
    ..A strategy is presented here which allows the study of these types of proteins and their variants by NMR which does not require carbon labelled samples...
  60. ncbi Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy
    R Powers
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 256:1673-7. 1992
    ....
  61. ncbi The -590C/T and -34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood
    K Elliott
    Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    J Allergy Clin Immunol 108:285-7. 2001
    ..Neither polymorphism predisposes to early-onset atopic eczema by itself, but suggestive linkage was found for the -590C/-34C haplotype in this study...
  62. ncbi A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor
    J F Gauchat
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Plan les Ouates, Switzerland
    Eur J Immunol 27:971-8. 1997
    ....
  63. ncbi Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function
    Yuling Wang
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:25196-203. 2004
    ..These findings suggest that Stat6 has mechanisms of regulation distinct from other Stats...
  64. ncbi Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...
  65. ncbi Horse cytokine/IgG fusion proteins--mammalian expression of biologically active cytokines and a system to verify antibody specificity to equine cytokines
    Bettina Wagner
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 105:1-14. 2005
    ....
  66. ncbi Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11
    S E Wenderfer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Genomics 63:354-73. 2000
    Five related cytokine genes, interleukin 3 (Il3), interleukin 4 (Il4), interleukin 5 (Il5), interleukin 13 (Il13), and granulocyte-macrophage colony-stimulating factor (Csfgm or Csf2), are tightly linked on mouse chromosome 11...
  67. ncbi Functional dissection identifies a conserved noncoding sequence-1 core that mediates IL13 and IL4 transcriptional enhancement
    Jannine M Strempel
    Functional Genomics Laboratory, Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 282:3738-46. 2007
    ....
  68. ncbi Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen
    W Debinski
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    Mol Med 6:440-9. 2000
    The vast majority of patients with high-grade gliomas (HGG) over-express interleukin 4 (IL4)-independent binding sites for IL13 in situ...
  69. ncbi Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 23:89-99. 2005
    ..Based on these probabilities, individual cells randomly express Il4 and Il13 alleles...
  70. ncbi Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development
    Aurelie Baguet
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 101:11410-5. 2004
    ..Our findings are consistent with a progressive regulatory element activation/deactivation model of TH1/TH2 development...
  71. ncbi The cattle interleukin-13 gene: genomic organization, chromosomal location, and evolution of the promoter
    J Buitkamp
    Department of Animal Breeding, Technical University Munich, Alte Akademie 12, D 85350 Freising Weihenstephan, Germany
    Immunogenetics 49:872-8. 1999
    ..There is evidence that IL-13, but not IL-14, is the key mediator in allergic asthma. Furthermore IL-13 is involved in resistance to some infections. Therefore IL-13 is of interest for disease association studies in domestic animals...
  72. ncbi Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha
    M G Malabarba
    Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Biol Chem 270:9630-7. 1995
    ....
  73. ncbi Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma
    R K Puri
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 56:5631-7. 1996
    ..We conclude that by localized administration, nontoxic levels of IL4(38-37)-PE38KDEL can be achieved, which may have significant cytotoxic activity against malignant astrocytoma...
  74. ncbi Epithelial interleukin-4 receptor expression promotes colon tumor growth
    Felicitas L Koller
    Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Carcinogenesis 31:1010-7. 2010
    ..Proliferation appears to be directly mediated via IL4Ralpha on the epithelial tumor cells. Survival may be an indirect response mediated via other host cells. Our results support therapeutic targeting of IL4Ralpha in colon cancer...
  75. ncbi The interleukin-2 and interleukin-4 receptors studied by molecular modelling
    P Bamborough
    Oxford Centre for Molecular Science, Physical Chemistry Laboratory, UK
    Structure 2:839-51. 1994
    ..They are therefore of interest as transmembrane signalling proteins, as well as potential pharmaceutical targets...
  76. ncbi Hodgkin lymphoma therapy with interleukin-4 receptor-directed cytotoxin in an infiltrating animal model
    Mariko Kawakami
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapeutics, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Bldg 29B 2E08, Bethesda, MD 20892, USA
    Blood 105:3707-13. 2005
    ..Because numerous H-RS cell lines express receptors for IL-4, IL-4 cytotoxin may be a unique agent for the treatment of Hodgkin lymphoma...
  77. ncbi Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia
    T Mainou-Fowler
    University Department of Haematology, School of Clinical and Laboratory Sciences, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Leuk Lymphoma 42:689-98. 2001
    ..49 and r=0.76, respectively). The significant differences observed in the production of IL4 by B-CLL B- and T-lymphocytes may suggest a paracrine function of IL4 in B-CLL...
  78. ncbi Roles for the interleukin-4 receptor and associated JAK/STAT proteins in human articular chondrocyte mechanotransduction
    S J Millward-Sadler
    Osteoarticular Research Group, Division of Pathology, University of Edinburgh, Medical School, Edinburgh, EH8 9AG, UK
    Osteoarthritis Cartilage 14:991-1001. 2006
    ....
  79. ncbi Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk
    Stefano Landi
    Genetics Department of Biology, University of Pisa, Via S Giuseppe 22, 56126, Pisa, Italy
    Eur J Cancer 43:762-8. 2007
    ..96; 95% CI=1.11-3.47; P-interaction=0.006). However, when sub-groups are analysed, the findings should be taken with caution for the weakening of the statistical power...
  80. ncbi Linkage and allelic association of atopy and markers flanking the IL4-receptor gene
    K A Deichmann
    University Children s Hospital, University of Freiburg, Germany
    Clin Exp Allergy 28:151-5. 1998
    ..In 1994 linkage of the 5q32 gene region and elevated total IgE levels were reported, leaving the IL4 gene as a prominent candidate...
  81. ncbi A critical control element for interleukin-4 memory expression in T helper lymphocytes
    Lars Oliver Tykocinski
    Deutsches Rheuma ForschungsZentrum, Berlin 10117, Germany
    J Biol Chem 280:28177-85. 2005
    ..The conserved intronic regulatory element thus links the initial epigenetic modification of the il4 gene to GATA-3 and serves as a genetic control element for memory expression of IL-4...
  82. ncbi JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering
    C Rolling
    INSERM U131, Institut Paris Sud sur les Cytokines, Clamart, France
    Oncogene 10:1757-61. 1995
    In human B cells, interleukin 4 (IL4) acts in regulating proliferation, antigen expression, isotype switching and differentiation...
  83. ncbi Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression
    Wei Liao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1288-96. 2008
    T helper type 2 (T(H)2) cells are essential for humoral immunity and host defense. Interleukin 4 (IL-4) drives T(H)2 differentiation and IL-2 augments the accessibility of Il4 chromatin...
  84. ncbi The levels of TNF alpha, IL4 and IL10 production by T-cells in B-cell chronic lymphocytic leukaemia (B-CLL)
    T Mainou-Fowler
    Department of Haematology, School of Clinical and Laboratory Sciences, Royal Victoria Infirmary, Queen Victoria Road, New Castle upon Tyne, NE1 4 LP, UK
    Leuk Res 25:157-63. 2001
    ..The differences observed with some B-CLL cases in the production of TNF alpha, IL4 and IL10 by peripheral blood T-cells may suggest survival mechanisms for the leukaemic cells in these patients...
  85. ncbi Poor responses to recombinant HBV vaccination in patients with HIV infection
    Neelam Pasricha
    Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Trop Gastroenterol 26:178-82. 2005
    ..Patients with a CD4 count of less than 50 failed to respond. Thus early immunization is advocated in all HIV patients at a stage when they are still capable of mounting an adequate immune response...
  86. ncbi Functional polymorphisms of interleukin 4 and interleukin 10 may predict evolution and functional outcome of an ischaemic stroke
    S Marousi
    Department of Neurology, University Hospital of Patras, Patras, Greece
    Eur J Neurol 18:637-43. 2011
    ..We sought to investigate whether functional polymorphisms of two anti-inflammatory molecules, interleukin (IL)4-589C>T and IL10-1082G>A, might be associated with the occurrence, clinical course and functional outcome of an acute IS...
  87. ncbi Development and in vitro characterization of recombinant vaccinia viruses expressing bovine leukemia virus gp51 in combination with bovine IL4 or IL12
    B R Von Beust
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164 7040, USA
    Vaccine 17:384-95. 1999
    ..In conclusion, bovine IL12 and IL4 expressed by recombinant vaccinia virus in vitro clearly exhibited type 1-type 2 modulating properties...
  88. ncbi CD30 antigen: not a physiological marker for TH2 cells but an important costimulator molecule in the regulation of the balance between TH1/TH2 response
    Patrizia Pellegrini
    Istituto CNR Trapianti d Organo e l Immunocitologia, Ple Collemaggio, 67100 L Aquila, Italy
    Transpl Immunol 12:49-61. 2003
    ....
  89. ncbi Localized Th1-, Th2-, T regulatory cell-, and inflammation-associated hepatic and pulmonary immune responses in Ascaris suum-infected swine are increased by retinoic acid
    Harry Dawson
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture, Beltsville, MD 20705, USA
    Infect Immun 77:2576-87. 2009
    ..Treatment with ATRA increased interleukin 4 (IL4) and IL12p70 in plasma of infected pigs at 7 DAI and augmented bronchoalveolar lavage (BAL) eosinophilia ..
  90. ncbi Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis
    D M Williams
    Audie L Murphy Memorial Veterans Hospital, and Department of Medicine, University of Texas Health Sciences Center at San Antonio, 78284, USA
    Infect Immun 65:2876-82. 1997
    ..Since IFN-gamma was dispensable in host defense, the highly effective mechanism or mechanisms which can compensate for its absence (which include TNF-alpha) deserve further study...
  91. ncbi [The role of infection in asthma]
    M Fernandez-Benitez
    Departamento de Alergología e Inmunología Clínica, Clinica Universitaria, Universidad de Navarra, Pamplona
    Allergol Immunopathol (Madr) 29:147-51. 2001
    ..In order to obtain our own results, we studied serum interleukin 4 (IL4) and interferon-gamma (IFN-gamma) in 42 children aged 3-17 years...
  92. ncbi IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:382-90. 2007
    ..These data imply a requirement for the IL-4/STAT6-pathway for onset of the clinical phase of SjS-like disease in the NOD mouse model...
  93. ncbi Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells
    A J McKnight
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 21:1187-94. 1991
    ..Since the differential production of lymphokines such as interferon-gamma (IFN-gamma) and interleukin 4 (IL4) is believed to regulate alternative effector responses to a particular antigen, we have compared the ..
  94. ncbi Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma
    Christiane Stahl-Hennig
    Deutsches Primatenzentrum, Gottingen, Germany
    Virology 305:473-85. 2003
    ..However, SIV-IL4 and SIV-IFN induced protection against a homologous challenge virus. Subsequent challenge with an SIV-HIV-1 hybrid virus (SHIV) also revealed protection in the absence of neutralizing antibodies...
  95. ncbi Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls
    L Zhang
    Department of Rheumatology and Immunology, Changzheng Hospital, Shanghai, China
    Ann Rheum Dis 68:1345-51. 2009
    ....
  96. ncbi Co-delivery of plasmid-encoded cytokines modulates the immune response to a DNA vaccine delivered by in vivo electroporation
    Hung Hsun Yen
    Centre for Animal Biotechnology, Faculty of Veterinary Science, University of Melbourne, VIC 3010, Australia
    Vaccine 25:2575-82. 2007
    ..Thus, co-delivery of plasmid-encoded cytokine genes with in vivo electroporation has the ability to effectively modulate immune responses to a DNA vaccine in a large animal...
  97. ncbi Expression of interleukin 4, interleukin 4 splice variants and interferon gamma mRNA in calves experimentally infected with Fasciola hepatica
    A S Waldvogel
    Institute of Veterinary Pathology, University of Berne, Langgass strasse 122, CH 3001 Berne, Switzerland
    Vet Immunol Immunopathol 97:53-63. 2004
    b>Interleukin 4 (IL-4) is expected to play a dominant role in the development of T helper (Th) 2 cells...
  98. ncbi Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease
    Juehua Gao
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Autoimmun 26:90-103. 2006
    ..B10-H2b.IL4-/- mice to synthesize anti-M3R autoantibodies of the IgG1 isotype apparently explains why these mice fail to develop exocrine gland dysfunction, despite exhibiting pre-clinical manifestations of SjS-like disease...
  99. ncbi Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis
    Geun Tae Kim
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Pusan National University, 1 10, Ami dong, Seo Gu, Busan, South Korea
    Clin Rheumatol 29:273-9. 2010
    ..that are associated with activation of CD4(+) T cells and inflammation including interferon gamma (IFNgamma), interleukin 4 (IL4), interleukin 17 (IL17), and tumor necrosis factor alpha (TNFalpha) in muscle tissues of patients with ..
  100. ncbi Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
    Yoshinori Naoe
    Institute of Physical and Chemical Research, Research Center for Allergy and Immunology, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 204:1749-55. 2007
    ..These results demonstrate critical roles of Runx complexes in regulating immune responses, at least in part, through the repression of the Il4 gene...
  101. ncbi Humoral and cell mediated immune response to cow's milk proteins in Behçet's disease
    G Triolo
    Dipartimento Biomedico di Medicina Interna e Specialistica Section of Rheumatology and Clinical Immunology, Policlinico Universitario, Palermo, Italy
    Ann Rheum Dis 61:459-62. 2002
    ..To investigate the humoral and cellular immune response against cow's milk proteins in Behçet's disease and to distinguish any behaviour during active or inactive disease...

Research Grants68

  1. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2011
    ..Our studies will be the first to explore human Th2 cytokine regulation in vivo and will identify novel rational targets for effective treatments of allergic disease. ..
  2. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2007
    ....
  3. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2010
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  4. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2011
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  5. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2009
    ..abstract_text> ..
  6. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..We hypothesize that this signaling pathway regulates epithelial, proliferative repair responses after renal injury. If correct, then this would impact on most forms of acute and chronic renal damage. ..
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..Based on our results in MDCK cells and zebrafish, we anticipate that these animals will develop renal cystic disease and will mimic human ADPKD most closely mechanistically. ..
  8. Targeted Toxin for Brain Cancer Gene Therapy
    Maria Castro; Fiscal Year: 2007
    ..In summary, we expect to develop a targeted glioma gene therapy approach with high therapeutic efficacy and negligible toxicity which could be translated into clinical trials. ..
  9. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian Hines; Fiscal Year: 2007
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  10. Gene Regulation by IL-4 and IL-13 in Airway Cells
    June Lee; Fiscal Year: 2004
    ..abstract_text> ..
  11. Characterization of Asthma Associated Polymorphisms
    Beverly H Koller; Fiscal Year: 2010
    ..However, there is no in vivo experimental data confirming the importance of these loci in the pathophysiology of asthma. This application plans to evaluate asthma candidate genes in the mouse, using genetic approaches. ..
  12. Molecular studies on the role of IL4 & IL13 in fibrosis
    Constantin Bona; Fiscal Year: 2007
    ..The effect of dominant-positive and dominant-negative constructs on collagen gene expression will be studied in the presence or absence of profibrogenic cytokines. ..
  13. ENVIRONMENT AND EPIGENETIC CONTROL OF IMMUNE RESPONSES
    Mark Bix; Fiscal Year: 2004
    ..abstract_text> ..
  14. IL4 REGULATION OF LYMPHOCYTE GENE EXPRESSION
    Mark Boothby; Fiscal Year: 1999
    b>Interleukin 4 (IL-40 plays several critical roles in the regulation of immune responses...
  15. NIP45--A NOVEL NUCLEAR PROTEIN THAT REGULATES IL4
    Laurie Glimcher; Fiscal Year: 2003
    The molecular basis for the tissue-specific expression of interleukin 4 (IL-4) in Th2 cells has begun to be elucidated...
  16. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  17. REGULATION OF ACIAD BY LYMPHOCYTES WITH NK MARKERS
    Joan Stein Streilein; Fiscal Year: 2001
    ..abstract_text> ..
  18. Anti-inflammatory Cytokines in Atherosclerosis
    William Boisvert; Fiscal Year: 2007
    ..These studies will highlight the importance of inflammation in atherosclerosis and may lead to development of new therapeutic measures targeting inflammation to reduce atherogenesis. ..
  19. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    ..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..