IL-4

Summary

Gene Symbol: IL-4
Description: interleukin 4
Alias: BCGF-1, BCGF1, BSF-1, BSF1, IL-4, B cell growth factor 1, B_cell stimulatory factor 1, binetrakin, interleukin-4, lymphocyte stimulatory factor 1, pitrakinra
Species: human

Top Publications

  1. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
  2. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
  3. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
  4. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
  5. ncbi Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  6. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
  7. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
  8. pmc Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling
    Yi Zeng
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Virol 81:2401-17. 2007
  9. ncbi A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood
    Michael Kabesch
    University Children s Hospital of Munich, Germany
    J Allergy Clin Immunol 112:893-8. 2003
  10. ncbi Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection
    Tzy Yen Chen
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Transl Res 150:116-21. 2007

Research Grants

Detail Information

Publications223 found, 100 shown here

  1. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  2. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
    ..Cytokine single nucleotide polymorphisms could play a role in the pathophysiology of BD. The results of this study could suggest a tendency towards higher production of IL-2 and lower production of IL-4 in the patients with BD...
  3. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
    ..The aim of the present study is to elucidate whether the single nucleotide polymorphisms (SNP) and the interaction of variants in the 5 genes are associated with the development of GD and Graves' ophthalmopathy (GO)...
  4. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
    ..An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production...
  5. ncbi Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  6. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  7. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
    ..These results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs...
  8. pmc Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling
    Yi Zeng
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, People s Republic of China
    J Virol 81:2401-17. 2007
    ..These findings suggest that Tat may participate in KS pathogenesis by inducing KSHV replication and increasing KSHV viral load. These data also suggest that JAK/STAT signaling may be of therapeutic value in AIDS-related KS patients...
  9. ncbi A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood
    Michael Kabesch
    University Children s Hospital of Munich, Germany
    J Allergy Clin Immunol 112:893-8. 2003
    ..Polymorphism C-589T was reported to influence total serum IgE levels and bronchial hyperresponsiveness. However, no study has investigated the putative existence of further SNPs in exons, introns, and flanking regions of the IL4 gene...
  10. ncbi Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection
    Tzy Yen Chen
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Transl Res 150:116-21. 2007
    ..05). These data suggested the distribution of polymorphism at TNF-alpha G308A may be different between normal subjects and patients with chronic infection of hepatitis C...
  11. pmc IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis
    Matthew R Macey
    Virginia Commonwealth University, Biology Department, Box 842012, Richmond, VA 23284 2012, USA
    J Immunol 184:4688-95. 2010
    ..Dysregulation of this balance may impact allergic disease and be amenable to targeted therapy...
  12. pmc Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants
    Livia Pedroza-Martins
    Department of Microbiology, Immunology, and Molecular Genetics, UCLA AIDS Institute, USA
    J Virol 76:6929-43. 2002
    ..Our studies suggest that coreceptor use by HIV primary isolates is important but is not the sole determinant of HIV pathogenesis in the thymus...
  13. doi Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses
    Elizabeth Forbes
    Malaghan Institute of Medical Research, Wellington, New Zealand
    Immunol Cell Biol 88:240-3. 2010
    ....
  14. ncbi Involvement of T(H)1/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris
    Abhigyan Satyam
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Immunol Invest 38:498-509. 2009
    ..The decreased levels of IL-2 and IFN-gamma might demonstrate the inhibitory effects by IL-4 and IL-10, which suppress the expansion of T(H)1 population...
  15. pmc Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling
    Elisabeth Maier
    Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
    J Biol Chem 286:919-28. 2011
    ..Thus, this study provides a model for an IL-4/STAT6-dependent fine tuning mechanism of TCF-1-driven T helper cell polarization...
  16. ncbi Interleukin-4 gene, but not the interleukin-1 beta gene polymorphism, is associated with oral cancer
    Ming Hsui Tsai
    Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 19:93-8. 2005
    ..However, whether the -590 C/T polymorphism of the IL4 gene plays a role in oral cancer remains unclear. Further substantiation based on larger patient samples is needed...
  17. doi Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients
    R Vasudevan
    Genetic Research Group, Molecular Biology and Bioinformatics Unit, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    Genet Mol Res 10:943-7. 2011
    Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with end-stage renal disease (ESRD) subjects in many different populations, although with conflicting results...
  18. doi IL-4 and IL-13 alter plasmacytoid dendritic cell responsiveness to CpG DNA and herpes simplex virus-1
    Jurjen Tel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 131:900-6. 2011
    ..Taken together, these results demonstrate that T(h)2 cytokines are involved in the modulation of pDC function and responsiveness to bacterial- and viral-derived stimuli...
  19. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
    ..In contrast, these changes were opposite, absent or partial in the OBS population. These findings support the use of Tat immunization to intensify HAART efficacy and to restore immune homeostasis...
  20. pmc No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 76:517-21. 2005
    ..Additional support from independent samples will be even more important in the study of gene-gene interactions and other subgroup analyses...
  21. ncbi Interleukin-4 gene intron-3 polymorphism is associated with transitional cell carcinoma of the urinary bladder
    Fuu Jen Tsai
    Department of Paediatrics, China Medical University Hospital, Taichung, Taiwan
    BJU Int 95:432-5. 2005
    ....
  22. ncbi Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Obstet Gynecol 104:293-300. 2004
    ..Differences in allelic carriage of immune system-related genes among white, black, and Hispanic pregnant women living in New York City and Boston were evaluated...
  23. ncbi Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma
    S G Lee
    Asan Institute for Life Sciences, University of Ulsan, Seoul, Korea
    Clin Exp Allergy 34:1202-8. 2004
    ..Interleukin-4 receptor alpha (IL-4Ralpha), which binds IL-4 and IL-13, is involved in signal transduction of those cytokines that lead to IgE production, and is also a key functional component of the Th2 lymphocyte phenotype...
  24. doi Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis
    Zhiguang Li
    National Laboratory of Biomacromolecules, Chinese Academy of Sciences University of Tokyo Joint Laboratory of Structural Virology and Immunology, Graduate School of Chinese Academy of Sciences, Institute of Biophysics, Beijing, China
    Cancer Res 68:8687-94. 2008
    ..These findings were helpful to understand the long clinical observation and revealed that endogenous IL-4, the product of host immune response, can be used by tumor cells to facilitate their growth...
  25. doi Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort
    S Black
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London NW1 2HE, UK
    Allergy 64:1172-8. 2009
    ....
  26. pmc Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring
    Nahid A Eid
    Department of Molecular Biology, Institute of Endemic Diseases, Medical Campus, Qasser Street, University of Khartoum, Khartoum, Sudan
    Malar J 9:119. 2010
    ....
  27. doi Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma
    Kittipong Maneechotesuwan
    Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Allergy Clin Immunol 123:239-48. 2009
    ..Indoleamine 2, 3-dioxygenase (IDO), a tryptophan-degrading enzyme in dendritic cells (DCs), mediates an immunosuppressive effect on activated T lymphocytes. However, little is known about the effect of Der p 1 on IDO in human DCs...
  28. ncbi Association between IL-4 genotype and IL-4 production in the Japanese population
    H Nakashima
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Genes Immun 3:107-9. 2002
    ..These results make it likely that IL-4 genotype could influence the type of immune response...
  29. doi Adipose derived stem cells (ASCs) isolated from breast cancer tissue express IL-4, IL-10 and TGF-β1 and upregulate expression of regulatory molecules on T cells: do they protect breast cancer cells from the immune response?
    Mahboobeh Razmkhah
    Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
    Cell Immunol 266:116-22. 2011
    ..Further investigation is required to see if the immune suppression induced by ASCs is an independent property from tumor cells or ASCs gain their immunosuppressive potential from malignant cells...
  30. ncbi Interferon-gamma +874A/T and interleukin-4 intron3 VNTR gene polymorphisms in Chinese patients with idiopathic thrombocytopenic purpura
    Xiaoli Chen
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    Eur J Haematol 79:191-7. 2007
    ....
  31. ncbi IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction
    N Buchs
    Departments of Immunology and Rheumatology, Hopital Edouard Herriot, Lyon, France, Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK and Department of Medicine, Tufts University
    Rheumatology (Oxford) 39:1126-31. 2000
    To evaluate the occurrence of variants of the interleukin 4 (IL-4) and IL-4 receptor (IL-4R) genes in patients with rheumatoid arthritis (RA) and their possible contribution to joint destruction.
  32. doi Interleukin-4 gene polymorphisms confer Behçet's disease in Turkish population
    H B Oral
    Department of Medical Microbiology, Immunology Unit, Uludag University Faculty of Medicine, Bursa, Turkey
    Scand J Immunol 73:594-601. 2011
    ..However, in order to confirm and assess the association of IL-4 and IL-4Rα gene polymorphisms with the BD, large cohort studies are needed...
  33. ncbi Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma
    Yao Yuan Hsieh
    Department of Obstetrics and Gynecology, National Chiao Tung University, Hsinchu, Taiwan
    Fertil Steril 87:886-95. 2007
    ..e., interleukin (IL)-1, IL-2, IL-4, IL-8, IL-12, and IL-18, which are all immunomodulatory cytokines that play important roles in host immune responses against cancers...
  34. pmc HIV-1 coinfection and morphine coexposure severely dysregulate hepatitis C virus-induced hepatic proinflammatory cytokine release and free radical production: increased pathogenesis coincides with uncoordinated host defenses
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Virol 85:11601-14. 2011
    ..The results suggest that opioid abuse and HIV-1 coinfection each further accelerate HCV-mediated liver disease by dysregulating immune defenses...
  35. pmc Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities
    T Yokota
    Proc Natl Acad Sci U S A 83:5894-8. 1986
    ..These results indicate that this human cDNA clone encodes a protein structurally and functionally homologous to mouse BSF-1...
  36. doi Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats
    Qingzhu Sun
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, China
    J Immunol 188:3506-12. 2012
    ..The findings may provide experimental evidence that PRMT1 plays an important role in asthma pathogenesis...
  37. pmc Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production
    D Schols
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Virol 70:4953-60. 1996
    ....
  38. doi VEGF and IL-4 gene variability and its association with the risk of coronary heart disease in north Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 341:139-48. 2010
    ..34, 95% CI 0.14-0.82, P < 0.01) and central obesity (OR 0.15, 95% CI 0.04-0.56, P < 0.001). GG genotype of VEGF has also shown significant association with IL-4 (P2P2 and P1P2) genotypes...
  39. pmc The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration
    Hamish T J Gilbert
    School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester M139PL, UK
    Arthritis Res Ther 13:R8. 2011
    ....
  40. ncbi Elevated interleukin-4 expression in severe recurrent hepatitis C virus after liver transplantation
    Sebastien Dharancy
    Laboratoire de Biologie Cellulaire, UPRES 1833, Faculté de Médecine Cochin Port Royal, Universite Paris 5, Paris, France
    Transplantation 83:906-11. 2007
    ..HCV frequently recurs after liver transplantation, and its course is accelerated in this setting. We compared in situ expression of IL-2 and IL-4 in transplanted and nontransplanted patients with HCV...
  41. pmc Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study
    Jiri Gallo
    Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
    BMC Med Genet 10:109. 2009
    ..This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype...
  42. doi Association of interleukin 4 -589T/C polymorphism with T(H)1 and T(H)2 bias and sepsis in Chinese major trauma patients
    Wei Gu
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Trauma 71:1583-7. 2011
    ..Whether this genetic variation is associated with sepsis susceptibility is unknown. The aim of this study was to search for the association of IL-4 -589T/C with the susceptibility to sepsis...
  43. ncbi The interleukin-4 site-2 epitope determining binding of the common receptor gamma chain
    F Letzelter
    Theodor Boveri Institut für Biowissenschaften Biozentrum der Universität, Physiologische Chemie II, Wurzburg, Germany
    Eur J Biochem 257:11-20. 1998
    ..This site-2 affinity seems to be sufficient, however, to promote, in a second step, a productive association of gamma(c) to an IL-4/alpha chain complex in the membrane...
  44. doi Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation
    Florian Göbel
    Institute of Immunology, Center of Physiology, Pathophysiology, and Immunology, Medical University of Vienna, Vienna, Austria
    Blood 114:3813-21. 2009
    ..GATA-1 mediates the repression of VDR and enables IL-4-dependent moDC differentiation. Conversely, VDR is induced downstream of transforming growth factor beta1 and is functionally involved in promoting LC differentiation...
  45. pmc Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4
    Michael Lohoff
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    J Biol Chem 285:1643-52. 2010
    ..Our study provides the first evidence that Egr-1 protein is differentially expressed in Th1 and Th2 cells and is involved in the acute phase of the IL-4 transcription in response to TCR stimulation...
  46. ncbi Protective effect of interleukin-4 -589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load
    Emi E Nakayama
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    J Infect Dis 185:1183-6. 2002
    ..04). Adjustment for early serum virus load greatly diminished the strength of this association. These results suggest that IL-4 -589T protects against HIV-1 disease progression by reducing virus load...
  47. ncbi Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain
    Jin Li Zhang
    Theodor Boveri Institut für Biowissenschaften, Biozentrum, Physiologische Chemie II, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Biochem Biophys Res Commun 300:291-6. 2003
    ..These results open the way to understand the molecular recognition mechanism in the IL-21 receptor system and also the promiscuous binding properties of gamma(c)...
  48. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  49. ncbi Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels
    I Suzuki
    First Department of Medicine, School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Clin Exp Allergy 30:1746-9. 2000
    ..05). The data suggest that IL-4 promoter C+33T polymorphism may be one of the genetic polymorphisms that explain genetic linkage or association between elevated total serum IgE levels and markers on chromosome 5q...
  50. ncbi IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway
    John F Grehan
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 175:1903-10. 2005
    ..We conclude that IL-4 and IL-13 can induce protection of porcine EC against killing by apoptosis and human complement through activation of the PI3K/Akt signaling pathway...
  51. pmc Regulation of eotaxin-3/CCL26 expression in human monocytic cells
    Victoria E L Stubbs
    Department of Physiology, University of Calgary, Alberta, Canada
    Immunology 130:74-82. 2010
    ..These data show that IL-4 and pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IFN-gamma regulate CCL26 synthesis in human monocytic cells, which may be important in regulating monocyte inflammatory responses...
  52. pmc Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children
    B A Gyan
    Immunology Unit, Noguchi Memorial Institute for Medical Research, Ghana
    Clin Exp Immunol 138:145-50. 2004
    ..Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria...
  53. ncbi Expression of 15-lipoxygenase type-1 in human mast cells
    Magdalena Gulliksson
    The Institute of Environmental Medicine, Division of Physiology, Unit for Experimental Asthma and Allergy Research, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Biochim Biophys Acta 1771:1156-65. 2007
    ..In conclusion, the expression of 15-LO-1 and release of 15-LO-1 derived products by mast cells may contribute to the role of these cells in asthma and other inflammatory diseases...
  54. ncbi Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4
    Di Qin
    Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, and Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, China
    Cell Microbiol 10:713-28. 2008
    ..Our data present the first direct evidence that HSV-1 can activate KSHV lytic replication and suggest a role of HSV-1 in KSHV pathogenesis...
  55. ncbi Interferon gamma (IFNgamma) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis
    M Vidyarani
    Tuberculosis Research Centre ICMR, Chennai, India
    Indian J Med Res 124:403-10. 2006
    ..The aim of our study was to find out whether Interferon gamma +874A and IL-4 -590T polymorphisms were associated with susceptibility to pulmonary tuberculosis as well as the level of IFNgamma and IL-4 in south Indian population...
  56. ncbi Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 113:489-95. 2004
    ..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors...
  57. ncbi A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
    ..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders...
  58. ncbi HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines
    Marco Vitale
    Department of Anatomy, Pharmacology and Forensic Medicine, Ospedale Maggiore, University of Parma, Italy
    Br J Haematol 120:337-43. 2003
    ..The property of p17 to increase the production of TNF-alpha and IFN-gamma might be a mechanism used by HIV-1 to modulate the immune system to support its replication and spreading...
  59. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  60. pmc Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos
    Teodorica L Bugawan
    Roche Molecular Systems, Alameda, CA 94501, USA
    Am J Hum Genet 72:1505-14. 2003
    ..Our data suggest that the risk for T1D is determined, in part, by polymorphisms within the IL4R locus, including promoter and coding-sequence variants, and by specific combinations of genotypes at the IL4R and the IL4 and IL13 loci...
  61. doi Association of interleukin-4 and interleukin-1 receptor antagonist gene polymorphisms and risk of benign prostatic hyperplasia
    Rituraj Konwar
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Urology 71:868-72. 2008
    ..The purpose of this study was to investigate the genetic association of polymorphisms of important cytokine genes (IL-4 and IL-1Ra) with the risk of BPH in a case-control study of a North Indian population...
  62. ncbi Association of non-HLA genes with type 1 diabetes autoimmunity
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 54:2482-6. 2005
    ..Genes involved in the IL-4 regulatory pathway (IL-4, IL-4R, IL-13) may confer susceptibility or protection to type 1 diabetes depending on individual SNPs or specific haplotypes...
  63. doi IL-4-mediated fine tuning of IL-12p70 production by human DC
    Emmanuella Guenova
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 38:3138-49. 2008
    ..Thus, we demonstrate that the Th2 cell cytokine IL-4 decisively determines the phenotype of ongoing immune responses by orchestrating the functional phenotype of newly immigrating DC precursors...
  64. doi T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome
    Elham Barkhordari
    Molecular Immunology Research Center and Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Inflammation 33:281-6. 2010
    ..001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS...
  65. doi Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
    Jaime S Rosa
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Pediatr Diabetes 9:9-16. 2008
    ....
  66. doi Gene expression polymorphisms of interleukins-1 beta, -4, -6, -8, -10, and tumor necrosis factors-alpha, -beta: regression analysis of their effect upon oral squamous cell carcinoma
    Eleftherios Vairaktaris
    Department of Maxillofacial Surgery, University of Athens Medical School, Attikon Hospital, Rimini 1, 12462, Athens, Greece
    J Cancer Res Clin Oncol 134:821-32. 2008
    ..The present retrospective case-control study examines possible interactions between seven cytokine genotype polymorphisms and their combinatory effect in predicting the occurrence of OSCC in Caucasians...
  67. ncbi Protective effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females
    Nuanjun Wichukchinda
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    AIDS 20:189-96. 2006
    ..To evaluate the effect of polymorphisms in interleukin-4 (IL4) and RANTES promoters on disease progression in HIV-1 infected Thais...
  68. ncbi Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice
    Eeva K Broberg
    Department of Virology, the MediCity Research Laboratory, and the Turku Graduate School of Biomedical Sciences, University of Turku, FIN 20520 Turku, Finland
    J Interferon Cytokine Res 22:641-51. 2002
    ..This is, to our knowledge, the first report to show elevated expression of IL-23 (p19) mRNA (p < 0.05) during viral infection in TG of mice...
  69. ncbi Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa
    G Luoni
    Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 2:411-4. 2001
    ..These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting...
  70. ncbi Cytokines and chronic rejection: a study in kidney transplant long-term survivors
    Mariafederica Uboldi de Capei
    Genetics Institute, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Piemonte, Italy
    Transplantation 77:548-52. 2004
    ....
  71. ncbi IL4-589C/T polymorphism and IgE levels in severe malaria
    Federica Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, Rome, Italy
    Acta Trop 90:205-9. 2004
    ..These results raise the possibility that there is a relationship between susceptibility to severe malaria, IgE production and genetic variation in the IL4 region, which merits further investigation in other epidemiological settings...
  72. ncbi IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins
    Concetta Conticello
    Department of Experimental Oncology, Mediterranean Institute of Oncology, Catania, Italy
    J Immunol 172:5467-77. 2004
    ..These findings may provide useful information for the development of therapeutic strategies aimed at restoring the functionality of apoptotic pathways in tumor cells...
  73. ncbi IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway
    Gregory B Carey
    Program in Oncology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Res 17:942-55. 2007
    ..These results suggest that the IL-4 receptor activates several signaling pathways, with the Akt pathway playing a major role in suppression of the apoptotic program activated by anti-IgM...
  74. doi Impact of the IL-4 -590 C/T transition on the levels of Plasmodium falciparum specific IgE, IgG, IgG subclasses and total IgE in two sympatric ethnic groups living in Mali
    Manijeh Vafa
    Department of Immunology, Stockholm University, S 106 91 Stockholm, Sweden
    Microbes Infect 11:779-84. 2009
    ..Taken together, these data indicate that the impact of IL-4 -590 variants on antibody levels may vary in different ethnic populations, and that this might affect the Ig-class and subclass distributions...
  75. ncbi Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells
    Nicola M Heller
    Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 31:573-82. 2004
    ..These observations have important implications for the regulation of epithelial cell activation by the balance of Th1/Th2-type cytokines in the airways in allergic disease...
  76. ncbi Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells
    Soo Ok Lee
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 68:85-91. 2008
    ..In this study, the role of IL-4 in promoting the growth of androgen-independent prostate cancer cells was examined...
  77. ncbi Allelic polymorphism of cytokine genes during pulmonary tuberculosis
    I O Naslednikova
    Department of Pathophysiology, Department of Phthisiology and Pulmonology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia
    Bull Exp Biol Med 148:175-80. 2009
    ....
  78. ncbi Genetic association of interleukin-4, interleukin-10, and transforming growth factor-beta gene polymorphism with allograft function in renal transplant patients
    M Amirzargar
    Kidney Transplant Division, Ekbatan Hospital, Hamadan University of Medical Sciences, Tehran, Iran
    Transplant Proc 39:954-7. 2007
    ..TGF-beta codon 10 T allele was 39% in RE, 35% in SGF, and 53% in control group. In conclusion, this study suggested that some cytokine gene alleles reflected SGF among kidney transplant recipients...
  79. pmc Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma
    Natalie C Battle
    University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Am J Respir Crit Care Med 175:881-7. 2007
    ..Furthermore, interaction between these genes has been shown to affect asthma in white and Chinese populations...
  80. ncbi IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis
    Ji Young Jang
    Department of Biological Science and Institute for Basic Science, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Cell Immunol 241:14-25. 2006
    ..In contrast, siRNA knock-out of ANT3 expression induced T cell apoptosis and blocked the IL-4-mediated cell survival. Together these results suggest that ANT3 has a potential role in Th cell survival and immune cell homeostasis...
  81. ncbi Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface
    T Hage
    Institut für Physiologische Chemie II, Theodor Boveri Institut für Biowissen Schaften Biozentrum, Universitat Wurzburg, Germany
    Cell 97:271-81. 1999
    ..Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided...
  82. pmc Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions
    O Prokopchuk
    Department of Visceral and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, 89075 Ulm, Germany
    Br J Cancer 92:921-8. 2005
    ....
  83. ncbi Association between cord blood IgE and genetic polymorphisms of interleukin-4, the beta-subunit of the high-affinity receptor for IgE, lymphotoxin-alpha, and tumor necrosis factor-alpha
    Hui Ju Wen
    Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan
    Pediatr Allergy Immunol 17:489-94. 2006
    ..Our finding suggested a significant association of cbIgE with genetic polymorphism of IL-4 -590C/T, but not with the genotypes of FcepsilonRI-beta, LT-alpha, and TNF-alpha...
  84. ncbi Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels
    Teri Roberts
    Molecular Biology and Human Genetics, Department of Biomedical Sciences, University of Stellenbosch, Cape Town, 7505, South Africa
    J Infect Dis 195:870-8. 2007
    ..Together, these results suggest that immunosuppression seen after mycobacterial stimulation in case patients with active TB is associated with naturally occurring regulatory T cells...
  85. ncbi The duplicitous effects of interleukin 4 on tumour immunity: how can the same cytokine improve or impair control of tumour growth?
    S Olver
    Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Tissue Antigens 69:293-8. 2007
    Successful tumour immunity relies on innate and adaptive immune responses, with cytokines like interleukin 4 (IL-4) known to influence tumour clearance in both positive and negative ways...
  86. ncbi The -590 IL-4 promoter polymorphism in patients with rheumatoid arthritis
    Andrzej Pawlik
    Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70 111 Szczecin, ul Powst Wlkp 72, Poland
    Rheumatol Int 26:48-51. 2005
    ..We suggest that the IL-4 -590 promoter polymorphism may be a genetic risk factor for RA severity...
  87. ncbi Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression
    L Walch
    UMR7131 CNRS Université Pierre et Marie Curie Paris 6, Hopital Broussais, 102 rue Didot, 75014 Paris, France
    Atherosclerosis 187:285-91. 2006
    ..Although considered as an anti-inflammatory cytokine, interleukin-4 (IL-4) has been shown to be pro-atherogenic in mice models of atherosclerosis...
  88. ncbi Human interleukin 4. The solution structure of a four-helix bundle protein
    L J Smith
    Inorganic Chemistry Laboratory, University of Oxford, England
    J Mol Biol 224:899-904. 1992
    ..m.r.) techniques have been used to determine the solution structure of human interleukin 4, a four-helix bundle protein...
  89. ncbi Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population
    B Beghe
    Divisions of Human Genetics Infection, Inflammation and Repair, School of Medicine, University of Southampton, UK
    Clin Exp Allergy 33:1111-7. 2003
    ..IL-4 by binding to its receptor (IL-4R) is essential for the development of airway inflammation present in asthma, through the induction of IgE synthesis in B cells and differentiation of T cells to a Th2 phenotype...
  90. pmc P110delta, a novel phosphoinositide 3-kinase in leukocytes
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1P 8BT, United Kingdom
    Proc Natl Acad Sci U S A 94:4330-5. 1997
    ..Possible selective functions of p110delta in white blood cells are discussed...
  91. ncbi Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma
    Tianpen Cui
    Immunology Laboratory, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022
    J Huazhong Univ Sci Technolog Med Sci 23:134-7. 2003
    ..127, respectively; P < 0.01)] and was correlated with the increased plasma total IgE. These data suggested that the IL-4R alpha chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China...
  92. ncbi IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21(Waf1), cyclin D1, and cyclin E expression
    Jinkoo Kim
    Vascular System Research Center, Kangwon National University, Chunchon 200 701, Korea
    Mol Cells 16:92-6. 2003
    ..These results show that IL-4 inhibits endothelial cell growth by altering the expression of cell cycle regulatory molecules...
  93. ncbi The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters
    Jin Li Zhang
    Department of Physiological Chemistry II, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Mol Biol 315:399-407. 2002
    ..These results show that the high-affinity IL-4/IL4-BP contact is constituted by two independent binding units, each containing a central polar or charged side-chain surrounded by hydrophobic groups (avocado cluster)...
  94. ncbi Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma
    Tianpen Cui
    Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P R of China
    Clin Chem Lab Med 41:888-92. 2003
    ..16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese...
  95. ncbi Association of interleukin-4 and interleukin-1B gene variants with Larsen score progression in rheumatoid arthritis
    Stephane Genevay
    University Hospital of Geneva, Switzerland
    Arthritis Rheum 47:303-9. 2002
    ..To perform a genetic association study using markers in the interleukin-1 (IL-1) gene cluster and the IL-4/IL-4 receptor system genes, seeking evidence for involvement in the onset or the erosive outcome of rheumatoid arthritis (RA)...
  96. ncbi Influence of patient and donor cytokine genotypes on renal allograft rejection: evidence from a single centre study
    K L Poole
    Histrocompatibility and Immunogenetics Laboratory, Southampton Unitversity Hospitals, UK
    Transpl Immunol 8:259-65. 2001
    ..However, due to conflicting results from this and other studies, a multi-centre collaborative study may be required to determine whether cytokine genotypes are significant, independent predictors of renal allograft rejection...
  97. ncbi Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population
    G P Aithal
    Centre for Liver Research, Medical School, University of Newcastle upon Tyne, UK
    Genes Immun 2:44-7. 2001
    ..005). Association with alleles resulting in high IL-4 transcription and enhanced signalling activity suggests that IL-4 may have a role in the pathogenesis of Crohn's disease...
  98. ncbi Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population
    J Javor
    Department of Immunology, School of Medicine, Comenius University, Saskinova 4, 811 08 Bratislava, Slovakia
    Int J Immunogenet 34:273-80. 2007
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases...
  99. ncbi IL-4 receptor alpha chain genetic polymorphism and total IgE levels in the English population: two-locus haplotypes are more informative than individual SNPs
    N Bottini
    Experimental Medicine Unit, University of Wales Swansea, UK
    Clin Genet 61:288-92. 2002
    ..With regard to individual SNPs (50 478 and 551), no significant association has been observed with IgE levels or with asthma, thus confirming the higher informative value of the haplotype analysis as compared to separate study on SNPs...
  100. ncbi Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy
    T Muller
    Theodor Boveri Institut für Biowissenschaften Biozentrum Universität Würzburg, Germany
    J Mol Biol 237:423-36. 1994
    ..A strategy is presented here which allows the study of these types of proteins and their variants by NMR which does not require carbon labelled samples...
  101. ncbi Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy
    R Powers
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 256:1673-7. 1992
    ....

Research Grants69

  1. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2011
    ..Our studies will be the first to explore human Th2 cytokine regulation in vivo and will identify novel rational targets for effective treatments of allergic disease. ..
  2. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2007
    ....
  3. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2009
    ..abstract_text> ..
  4. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2011
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  5. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2010
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  6. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..We hypothesize that this signaling pathway regulates epithelial, proliferative repair responses after renal injury. If correct, then this would impact on most forms of acute and chronic renal damage. ..
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..Based on our results in MDCK cells and zebrafish, we anticipate that these animals will develop renal cystic disease and will mimic human ADPKD most closely mechanistically. ..
  8. Targeted Toxin for Brain Cancer Gene Therapy
    Maria Castro; Fiscal Year: 2007
    ..In summary, we expect to develop a targeted glioma gene therapy approach with high therapeutic efficacy and negligible toxicity which could be translated into clinical trials. ..
  9. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian Hines; Fiscal Year: 2007
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  10. Gene Regulation by IL-4 and IL-13 in Airway Cells
    June Lee; Fiscal Year: 2004
    ..abstract_text> ..
  11. Characterization of Asthma Associated Polymorphisms
    Beverly H Koller; Fiscal Year: 2010
    ..However, there is no in vivo experimental data confirming the importance of these loci in the pathophysiology of asthma. This application plans to evaluate asthma candidate genes in the mouse, using genetic approaches. ..
  12. Molecular studies on the role of IL4 & IL13 in fibrosis
    Constantin Bona; Fiscal Year: 2007
    ..The effect of dominant-positive and dominant-negative constructs on collagen gene expression will be studied in the presence or absence of profibrogenic cytokines. ..
  13. ENVIRONMENT AND EPIGENETIC CONTROL OF IMMUNE RESPONSES
    Mark Bix; Fiscal Year: 2004
    ..abstract_text> ..
  14. IL4 REGULATION OF LYMPHOCYTE GENE EXPRESSION
    Mark Boothby; Fiscal Year: 1999
    b>Interleukin 4 (IL-40 plays several critical roles in the regulation of immune responses...
  15. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  16. NIP45--A NOVEL NUCLEAR PROTEIN THAT REGULATES IL4
    Laurie Glimcher; Fiscal Year: 2003
    The molecular basis for the tissue-specific expression of interleukin 4 (IL-4) in Th2 cells has begun to be elucidated...
  17. REGULATION OF ACIAD BY LYMPHOCYTES WITH NK MARKERS
    Joan Stein Streilein; Fiscal Year: 2001
    ..abstract_text> ..
  18. Anti-inflammatory Cytokines in Atherosclerosis
    William Boisvert; Fiscal Year: 2007
    ..These studies will highlight the importance of inflammation in atherosclerosis and may lead to development of new therapeutic measures targeting inflammation to reduce atherogenesis. ..
  19. LIVER LUNG INTERACTIONS DURING GRAM NEGATIVE ENDOTOXEMIA
    George Matuschak; Fiscal Year: 1999
    ..This should provide novel insights into the regulation of cytokine expression during gram negative sepsis while identifying mechanistic therapies to ameliorate acute lung injury and multiple organ failure. ..