IL 22

Summary

Gene Symbol: IL 22
Description: interleukin 22
Alias: IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, interleukin-22, IL-10-related T-cell-derived inducible factor, cytokine Zcyto18
Species: human
Products:     IL 22

Top Publications

  1. Wolk K, Witte E, Hoffmann U, Doecke W, Endesfelder S, Asadullah K, et al. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol. 2007;178:5973-81 pubmed
    ..These data suggest that systemic IL-22 may contribute to the prevention of systemic inflammation provoked by LPS present in the blood of CD patients through its induction of hepatic LBP. ..
  2. Zhang W, Chen Y, Wei H, Zheng C, Sun R, Zhang J, et al. Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts. Clin Cancer Res. 2008;14:6432-9 pubmed publisher
    ..Our study indicates that autocrine production of IL-22 contributes to human lung cancer cell survival and resistance to chemotherapy through the up-regulation of antiapoptotic proteins. ..
  3. Fukui H, Sekikawa A, Tanaka H, Fujimori Y, Katake Y, Fujii S, et al. DMBT1 is a novel gene induced by IL-22 in ulcerative colitis. Inflamm Bowel Dis. 2011;17:1177-88 pubmed publisher
    ..The IL-22/DMBT1 axis may play a pivotal role in the pathophysiology of UC. ..
  4. Eyerich S, Eyerich K, Pennino D, Carbone T, Nasorri F, Pallotta S, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 2009;119:3573-85 pubmed publisher
    ..Future strategies directed against the Th22 subset may be of value in chronic inflammatory skin disorders...
  5. Whittington H, Armstrong L, Uppington K, Millar A. Interleukin-22: a potential immunomodulatory molecule in the lung. Am J Respir Cell Mol Biol. 2004;31:220-6 pubmed
    ..By contrast, we demonstrated synergy between IL-10 and IL-22 in terms of IL-8 inhibition in IL-22R1-expressing A549 cells. These data suggest a role for IL-22 in the regulation of pulmonary inflammation. ..
  6. Sekikawa A, Fukui H, Suzuki K, Karibe T, Fujii S, Ichikawa K, et al. Involvement of the IL-22/REG Ialpha axis in ulcerative colitis. Lab Invest. 2010;90:496-505 pubmed publisher
    ..The IL-22-responsive element was located between -142 and -134 in the REG Ialpha promoter region. REG Ialpha protein may have a pathophysiological role as a biological mediator for immune cell-derived IL-22 in the UC mucosa. ..
  7. Bingold T, Ziesché E, Scheller B, Sadik C, Franck K, Just L, et al. Interleukin-22 detected in patients with abdominal sepsis. Shock. 2010;34:337-40 pubmed publisher
    b>Interleukin 22 (IL-22) is a TH17-like cytokine known to specifically activate epithelial cells, thereby strengthening immune defense at host/environment interfaces...
  8. Zhang G, Chen X, Chan L, Zhang M, Zhu B, Wang L, et al. An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese. Sci Rep. 2011;1:20 pubmed publisher
    ..Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations. ..
  9. Kim K, Kim H, Park J, Park J, Oh H, Woo Y, et al. Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts. Arthritis Rheum. 2012;64:1015-23 pubmed publisher
    ..To examine the regulatory role of interleukin-22 (IL-22) in the expression of RANKL and induction of osteoclastogenesis in rheumatoid arthritis (RA)...

More Information

Publications63

  1. Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lennerz J, et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009;457:722-5 pubmed publisher
  2. Yu L, Wang H, Yang S, Yuan Z, Xu F, Sun C, et al. Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis. World J Gastroenterol. 2013;19:2638-49 pubmed publisher
    ..IL-22/STAT3 signaling pathway may be related to UC and UC-induced carcinogenesis and IL-22 can be used as a biomarker in judging the severity of UC. ..
  3. Ding G, Zhang G, Chen X, ZHANG M, Yang L, Wang Z. [A study on the relationship between single nucleotide polymorphisms of interleukin-22 and susceptibility to pulmonary tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2012;35:596-600 pubmed
    ..The allele G was the risk factor of pulmonary tuberculosis. The SNP (rs2227473) may play an important role in the protective immune process against tuberculosis by affecting the IL-22 expression of PBMCs. ..
  4. Ciccia F, Guggino G, Rizzo A, Ferrante A, Raimondo S, Giardina A, et al. Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren's syndrome. Ann Rheum Dis. 2012;71:295-301 pubmed publisher
    ..Th17 and NKp44(+) NK cells were the major cellular sources of IL-22 in patients with pSS. Our results suggest that, together with IL-17 and IL-23, IL-22 may play a pro-inflammatory role in the pathogenesis of pSS. ..
  5. Jones B, Logsdon N, Walter M. Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure. 2008;16:1333-44 pubmed publisher
  6. Jiang R, Wang H, Deng L, Hou J, Shi R, Yao M, et al. IL-22 is related to development of human colon cancer by activation of STAT3. BMC Cancer. 2013;13:59 pubmed publisher
    ..In this study we demonstrated that excessive IL-22 in the CC and UC microenvironment leads to tumor growth, inhibition of apoptosis, and promotion of metastasis depend on STAT3 activation. ..
  7. Dhiman R, Indramohan M, Barnes P, Nayak R, Paidipally P, Rao L, et al. IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion. J Immunol. 2009;183:6639-45 pubmed publisher
    ..tuberculosis through production of IL-22, which inhibits intracellular mycobacterial growth by enhancing phagolysosomal fusion. IL-15 and DAP-10 elicit IL-22 production by NK cells in response to M. tuberculosis. ..
  8. Thompson C, Plummer S, Tucker T, Casey G, Li L. Interleukin-22 genetic polymorphisms and risk of colon cancer. Cancer Causes Control. 2010;21:1165-70 pubmed publisher
    ..52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer. ..
  9. Wen Z, Liao Q, Zhao J, Hu Y, You L, Lu Z, et al. High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2014;21:125-32 pubmed publisher
    ..These findings reveal the positive role of IL-22 and IL-22R in invasion and metastasis in human PDAC. IL-22 and IL-22R may be suitable independent prognostic markers in PDAC. ..
  10. Kobold S, Völk S, Clauditz T, Küpper N, Minner S, Tufman A, et al. Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells. J Thorac Oncol. 2013;8:1032-42 pubmed publisher
    ..Enhanced IL-22-R1 expression and signaling in chemotherapy-refractory cell lines are indicative of a protumorigenic function of IL-22 and may contribute to a more aggressive phenotype. ..
  11. Dumoutier L, Van Roost E, Colau D, Renauld J. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci U S A. 2000;97:10144-9 pubmed
  12. Wong C, Lun S, Ko F, Wong P, Hu S, Chan I, et al. Activation of peripheral Th17 lymphocytes in patients with asthma. Immunol Invest. 2009;38:652-64 pubmed
    ..Pro-inflammatory cytokine IL-23 can exacerbate disease severity by activating pathogenic Th17 lymphocytes to release downstream inflammatory cytokine IL-22 in asthma. ..
  13. Cai T, Wang Q, Zhou Q, Wang C, Hou S, Qi J, et al. Increased expression of IL-22 is associated with disease activity in Behcet's disease. PLoS ONE. 2013;8:e59009 pubmed publisher
    ..IL-22 was associated with disease activity in BD and correlated with the presence of small vessel inflammation, suggesting that it may be involved in its pathogenesis. ..
  14. Bard J, Gelebart P, Anand M, Amin H, Lai R. Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma. Leukemia. 2008;22:1595-603 pubmed publisher
    ..To conclude, for the first time, we demonstrate the importance of the IL-22 autocrine pathway in a lymphoid malignancy, and reveal yet another novel function of NPM-ALK. ..
  15. Aujla S, Chan Y, Zheng M, Fei M, Askew D, Pociask D, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med. 2008;14:275-81 pubmed publisher
    ..These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites. ..
  16. Eyerich S, Wagener J, Wenzel V, Scarponi C, Pennino D, Albanesi C, et al. IL-22 and TNF-? represent a key cytokine combination for epidermal integrity during infection with Candida albicans. Eur J Immunol. 2011;41:1894-901 pubmed publisher
    ..In summary, we demonstrate that IL-22 and TNF-? represent a potent, synergistic cytokine combination for cutaneous immunity. ..
  17. Dambacher J, Beigel F, Zitzmann K, Heeg M, Goke B, Diepolder H, et al. The role of interleukin-22 in hepatitis C virus infection. Cytokine. 2008;41:209-16 pubmed publisher
    ..Taken together, hepatic IL-22 expression is up-regulated in viral hepatitis but IL-22 does not directly regulate antiviral proteins and has, in contrast to IFN-alpha, no effect on HCV replication. ..
  18. Savan R, McFarland A, Reynolds D, Feigenbaum L, Ramakrishnan K, Karwan M, et al. A novel role for IL-22R1 as a driver of inflammation. Blood. 2011;117:575-84 pubmed publisher
    ..This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in ALK(+)ALCL. ..
  19. Dumoutier L, Louahed J, Renauld J. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol. 2000;164:1814-9 pubmed
    ..Further studies will have to address the possibility that some of the IL-9 activities may be mediated by IL-TIF. ..
  20. Rutz S, Eidenschenk C, Ouyang W. IL-22, not simply a Th17 cytokine. Immunol Rev. 2013;252:116-32 pubmed publisher
    ..Here, we discuss the production of IL-22 from various T-cell populations as well as protective versus pathogenic roles of IL-22. Finally, we focus on recent advances in our understanding of the molecular regulation of IL-22 in T cells. ..
  21. Sestito R, Madonna S, Scarponi C, Cianfarani F, Failla C, Cavani A, et al. STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation. FASEB J. 2011;25:916-27 pubmed publisher
    ..In skin affected by psoriasis, SIRT1 is down-regulated by IFN-?, which thus renders psoriatic keratinocytes more prone to respond to IL-22. ..
  22. Shen H, Goodall J, Hill Gaston J. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum. 2009;60:1647-56 pubmed publisher
    ..These data support the hypothesis that Th17 cells, particularly when present in excess of IL-10-producing cells, are involved in the pathogenesis of inflammatory arthritis. ..
  23. Xiang X, Gui H, King N, Cole L, Wang H, Xie Q, et al. IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus-infected liver. Immunol Cell Biol. 2012;90:611-9 pubmed publisher
    ..We speculate that IL-22 and non-ELR-CXC chemokines synergistically may provide protection in liver inflammation/fibrosis during CHB infection. ..
  24. Park O, Wang H, Weng H, Feigenbaum L, Li H, Yin S, et al. In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression. Hepatology. 2011;54:252-61 pubmed publisher
    ..These findings indicate that localized production of IL-22 in the liver promotes hepatocyte survival and proliferation but primes the liver to be more susceptible to tumor development without significantly affecting liver inflammation. ..
  25. Petanidis S, Anestakis D, Argyraki M, Hadzopoulou Cladaras M, Salifoglou A. Differential expression of IL-17, 22 and 23 in the progression of colorectal cancer in patients with K-ras mutation: Ras signal inhibition and crosstalk with GM-CSF and IFN-?. PLoS ONE. 2013;8:e73616 pubmed publisher
  26. Kotenko S, Izotova L, Mirochnitchenko O, Esterova E, Dickensheets H, Donnelly R, et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J Biol Chem. 2001;276:2725-32 pubmed
  27. Zhu J, Cao Y, Li K, Wang Z, Zuo P, Xiong W, et al. Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. Asian Pac J Allergy Immunol. 2011;29:266-72 pubmed
    ..Our results suggested that both AhR and IL-22 might be involved in the pathogenesis of allergic asthma in human and the level of IL-22 might have some relationship with the severity of the disease. ..
  28. Pennino D, Bhavsar P, Effner R, Avitabile S, Venn P, Quaranta M, et al. IL-22 suppresses IFN-?-mediated lung inflammation in asthmatic patients. J Allergy Clin Immunol. 2013;131:562-70 pubmed publisher
    ..IL-22 controls tissue homeostasis by both proinflammatory and anti-inflammatory effects. However, the anti-inflammatory mechanisms of IL-22 remain poorly investigated...
  29. Zhang N, Pan H, Ye D. Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention. Mol Cell Biochem. 2011;353:41-6 pubmed publisher
    ..In summary, Th22 cell plays an important and complicated role in inflammatory and autoimmune disease. ..
  30. Eyerich K, Foerster S, Rombold S, Seidl H, Behrendt H, Hofmann H, et al. Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22. J Invest Dermatol. 2008;128:2640-5 pubmed publisher
    ..The inability to clear C. albicans in CMC patients could be due to a defect in the immune response of IL-17-producing T cells...
  31. Leipe J, Schramm M, Grunke M, Baeuerle M, Dechant C, Nigg A, et al. Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann Rheum Dis. 2011;70:1453-7 pubmed publisher
    To study the role of interleukin 22 (IL-22) in rheumatoid arthritis (RA). IL-22 serum levels were measured in patients with early, treatment-naive RA (n=49) and in 45 age- and sex-matched healthy individuals as controls...
  32. Jiang R, Tan Z, Deng L, Chen Y, Xia Y, Gao Y, et al. Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology. 2011;54:900-9 pubmed publisher
    ..Excessive IL-22 can be found in the HCC microenvironment, leading to tumor growth, inhibition of apoptosis, and promotion of metastasis due to STAT3 activation. ..
  33. Brand S, Dambacher J, Beigel F, Zitzmann K, Heeg M, Weiss T, et al. IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1019-28 pubmed
    ..In conclusion, IL-22 promotes liver cell regeneration by increasing hepatic cell proliferation and hepatocyte migration through the activation of Akt and STAT signaling, which is abrogated by SOCS-1/3 overexpression. ..
  34. Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst S, Otte J, et al. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2006;290:G827-38 pubmed
    ..IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and IEC migration. ..
  35. Lim C, Savan R. The role of the IL-22/IL-22R1 axis in cancer. Cytokine Growth Factor Rev. 2014;25:257-71 pubmed publisher
  36. Mathian A, Parizot C, Dorgham K, Trad S, Arnaud L, Larsen M, et al. Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Ann Rheum Dis. 2012;71:1227-34 pubmed publisher
    ..Active and diffuse forms of the disease are associated with a FoxP3 signature. Altogether, our data depict a status of regulatory/pro-inflammatory T cell imbalance in SSc. ..
  37. Kagami S, Rizzo H, Lee J, Koguchi Y, Blauvelt A. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol. 2010;130:1373-83 pubmed publisher
    ..In summary, elevated numbers of circulating inflammatory T cells may contribute to cutaneous inflammation and systemic inflammatory disease that occurs in individuals with psoriasis. ..
  38. Radaeva S, Sun R, Pan H, Hong F, Gao B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology. 2004;39:1332-42 pubmed
  39. Zhang Y, Cobleigh M, Lian J, Huang C, Booth C, Bai X, et al. A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology. 2011;141:1897-906 pubmed publisher
    ..These findings might be relevant to the development of cytokine-based therapies for patients with HBV infection. ..
  40. Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider Burrus S, Witte K, et al. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol. 2011;186:1228-39 pubmed publisher
    ..We conclude that IL-22 deficiency may contribute to the pathogenesis of certain chronic disorders as postulated in this paper for AI. ..
  41. Hoegl S, Bachmann M, Scheiermann P, Goren I, Hofstetter C, Pfeilschifter J, et al. Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2011;44:369-76 pubmed publisher
    ..These data support the hypothesis that IL-22, likely via activation of STAT3 and downstream genes (e.g., SOCS3), is able to protect against cell stretch and pulmonary baro-/biotrauma by enhancing epithelial cell resistibility. ..
  42. Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity. 2014;40:772-784 pubmed publisher
    ..Thus, IL-22(+) cells promote colon cancer stemness via regulation of stemness genes that negatively affects patient outcome. Efforts to target this network might be a strategy in treating colorectal cancer patients. ..
  43. Xie M, Aggarwal S, Ho W, Foster J, Zhang Z, Stinson J, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem. 2000;275:31335-9 pubmed
  44. Matthews K, Wilkinson K, Kalsdorf B, Roberts T, Diacon A, Walzl G, et al. Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. Tuberculosis (Edinb). 2011;91:587-93 pubmed publisher
    ..We propose that our findings support a role for IL-22 in TB-induced pathology or the resulting repair process. ..
  45. Hennig B, Frodsham A, Hellier S, Knapp S, Yee L, Wright M, et al. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. Liver Int. 2007;27:1134-43 pubmed
    ..We furthermore report on allele and haplotype frequencies and linkage disequilibrium for IL-10RA and IL-22. Our results indicate that genetic variation in these genes may play a modulatory role in the outcome of hepatitis C infection. ..
  46. Andoh A, Zhang Z, Inatomi O, Fujino S, Deguchi Y, Araki Y, et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology. 2005;129:969-84 pubmed
    ..IL-22 derived from activated T cells acts on SEMFs to elicit expression of proinflammatory cytokines and matrix-degrading molecules indicating proinflammatory/remodeling roles in IBD. ..
  47. Wang B, Zhao X, Fan Y, Zhang J, Zhao J, Wang K. IL-17A but not IL-22 suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line. Antiviral Res. 2013;97:285-92 pubmed publisher
    ..We demonstrated that IL-17A effectively suppressed HBV replication in a noncytopathic manner and the over-expression of MxA and OAS mRNA was involved in the suppression of HBV replication by IL-17A...
  48. Qin W, Chen L, Pan H, Leng R, Zhai Z, Wang C, et al. Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients. Clin Exp Med. 2011;11:245-50 pubmed publisher
    ..01). In conclusion, increased frequencies of IL-22-positive CD4+ T cells in patients with SLE and positive correlation with SLEDAI score and lupus nephritis suggest that this cytokine may be implicated in the pathogenesis of the disease. ..
  49. Zhao J, Zhang Z, Luan Y, Zou Z, Sun Y, Li Y, et al. Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment. Hepatology. 2014;59:1331-42 pubmed publisher
    ..IL-22 plays a pathological role in exacerbating chronic liver inflammation and fibrosis by recruiting hepatic Th17 cells in HBV-infected patients and HBV Tg mice. ..
  50. Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa J, Renauld J. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem. 2002;277:33676-82 pubmed
    ..Finally, by overexpressing a STAT3 S727A mutant, we showed that serine phosphorylation is required to achieve maximum transactivation of a STAT responsive promoter upon IL-22 stimulation. ..
  51. Fukui H, Zhang X, Sun C, Hara K, Kikuchi S, Yamasaki T, et al. IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling. Br J Cancer. 2014;111:763-71 pubmed publisher
    ..The invasive ability of gastric cancer cells was significantly enhanced by co-culture with IL-22-expressing CAFs. Interleukin-22 produced by CAFs promotes gastric cancer cell invasion via STAT3 and ERK signalling. ..
  52. Eun Y, Shin I, Lee Y, Shin S, Kim S, Chung J, et al. Interleukin 22 polymorphisms and papillary thyroid cancer. J Endocrinol Invest. 2013;36:584-7 pubmed publisher
    IL22RA1 (Interleukin 22 receptor-alpha 1), a member of the class II cytokine receptor family, mediates diverse biologic activities and appears to be important in pathogen defense, wound healing, and tissue reorganization...
  53. Kim S, Hur M, Choi B, Kim M, Lee Y, Choe Y, et al. A preliminary study of new single polymorphisms in the T helper type 17 pathway for psoriasis in the Korean population. Clin Exp Immunol. 2017;187:251-258 pubmed publisher
    ..In conclusion, we report two new psoriasis-susceptibility loci, in IL17F and JAK2, as well as a newly identified late-onset associated protective JAK2 locus and a protective JAK1 haplotype in the Korean population. ..
  54. Wu L, Liu S, Liu Y, Guo C, Li H, Li W, et al. Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C. Clin Immunol. 2015;158:77-87 pubmed publisher
    ..Collectively, our data provide evidence that IL-22 may contribute to the fibrogenesis of HCV-associated liver fibrosis by activating HSCs. ..