IL-1beta

Summary

Gene Symbol: IL-1beta
Description: interleukin 1, beta
Alias: IL-1, IL1-BETA, IL1F2, IL-1 beta, catabolin, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
Species: human

Top Publications

  1. ncbi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
  2. ncbi Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
  3. ncbi Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
  4. ncbi Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    Y D Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 4:155-62. 2001
  5. ncbi TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
  6. ncbi Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e5810. 2009
  7. ncbi Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
    Deepti Verma
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 58:888-94. 2008
  8. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
  9. ncbi Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
  10. ncbi Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells
    Yong Dae Kim
    Department of Otorhinolaryngology, College of Medicine, Yeungnam University, Nam Gu, Daegu, South Korea
    Mol Pharmacol 62:1112-8. 2002

Research Grants

  1. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
  2. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
  3. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Silvia S Pierangeli; Fiscal Year: 2010
  4. Genetic susceptibility to gastric cancer in Latin America
    Eduardo Tarazona Santos; Fiscal Year: 2007
  5. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona Santos; Fiscal Year: 2010
  6. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
  7. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
  8. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2006
  9. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
  10. CANDIDA ADHERENCE & PENETRATION OF VASCULAR ENDOTHELIUM
    John Edwards; Fiscal Year: 1993

Detail Information

Publications211 found, 100 shown here

  1. ncbi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  2. ncbi Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  3. ncbi Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
    ....
  4. ncbi Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    Y D Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 4:155-62. 2001
    ..These data demonstrate that IL-1 beta may induce VEGF in hVSMCs, and suggest that this paracrine signaling pathway, may prevent, in part, apoptosis of ECs...
  5. ncbi TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
    ..Collectively, our results suggest that while TRAF6 autoubiquitination may serve as a marker of activation, it is unlikely to underpin RING finger-dependent TRAF6 function...
  6. ncbi Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e5810. 2009
    ..Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen...
  7. ncbi Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
    Deepti Verma
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 58:888-94. 2008
    ..We undertook this study to determine whether a patient with arthritis and antibiotic-resistant fever carried mutations in the genes encoding the NALP3 inflammasome...
  8. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
    ..Thus, the inflammasome constitutes an important arm of the innate immunity...
  9. ncbi Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
    ..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
  10. ncbi Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells
    Yong Dae Kim
    Department of Otorhinolaryngology, College of Medicine, Yeungnam University, Nam Gu, Daegu, South Korea
    Mol Pharmacol 62:1112-8. 2002
    ..These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production...
  11. ncbi Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex
    Adel M Nour
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 286:17921-33. 2011
    ..We conclude that NLRP3 inflammasome formation is an innate cellular response to infection with this common pathogenic human herpesvirus...
  12. ncbi Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection
    Tamia K Lapointe
    Department of Biological Sciences and Inflammation Research Network, University of Calgary, Alberta, Canada
    Cell Microbiol 12:692-703. 2010
    ..pylori disrupts gastric epithelial barrier structure via IL-1RI-dependent activation of ROCK, which in turn mediates tight junctional claudin-4 disruption...
  13. ncbi The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    Michael Frosch
    University of Muenster, Muenster, Germany
    Arthritis Rheum 60:883-91. 2009
    ..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
  14. ncbi RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..In summary, HuR plays an important role in suppression of TM protein synthesis in IL-1beta treatment and sepsis...
  15. ncbi Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    Miyako Okamoto
    Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:6477-88. 2010
    ....
  16. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  17. ncbi Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:11802-10. 2002
    ..Interaction between HSF1 and NF-IL6 could thus be an important mechanism in HSF1 regulation of general gene transcription during endotoxin stress...
  18. ncbi Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  19. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  20. ncbi Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:1793-803. 2002
    ....
  21. ncbi Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
    L M Gomez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas, CIB, Medellin, Colombia
    Tissue Antigens 67:290-6. 2006
    ..These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1beta in the pathogenesis of mycobacterial infection...
  22. ncbi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  23. ncbi IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level
    J Sainz
    Unidad de Investigacion, Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Clin Immunol 28:473-85. 2008
    ..The aim of this study was to determine whether interleukin-1 alpha (IL1alpha), interleukin-1 beta (IL1beta), and IL1 receptor antagonist (IL1Ra) polymorphisms are implicated in invasive pulmonary aspergillosis (IPA) pathogenesis...
  24. ncbi Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis
    Liang Liu
    Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China
    Psychiatry Res 176:1-7. 2010
    ..IL-1beta and TNF-alpha may influence the symptoms of schizophrenia in the cognition dysfunction and anxiety/depression domains of the PANSS...
  25. ncbi Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:25900-12. 2008
    ..This novel pathway is a parallel pathway to the PI 3-kinase/AKT upstream of NFkappaB and both are involved in IL-6 gene transcription in response to IL-1...
  26. ncbi Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human monocyte-derived macrophages
    Ludivine Billiet
    U 545 INSERM, Institut Pasteur de Lille and Université Lille 2, 59019 Lille, France
    J Biol Chem 280:40310-8. 2005
    ..Taken together, these data indicated a potential new mechanism through which extracellular rhTrx-1 exerts an anti-inflammatory function in HMDM...
  27. ncbi Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease
    Robert C Read
    Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Ann Intern Med 138:534-41. 2003
    ..Genetically determined variation in proinflammatory cytokine release influences severity of meningococcal disease and other serious infections...
  28. ncbi Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist
    Omid Khalilzadeh
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, Tehran, Iran
    Clin Experiment Ophthalmol 37:614-9. 2009
    ..This study aimed to investigate the association of GO with single-nucleotide polymorphisms (SNPs) in the IL-1 family (IL-1alpha, IL-1beta, IL-1 receptor [IL-1R] and IL-1 receptor antagonist [IL-1RA])...
  29. ncbi HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)
    Adelina Holguin
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Pain 110:517-30. 2004
    ..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines...
  30. ncbi Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  31. ncbi Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 97:5580-5. 2000
    ....
  32. ncbi Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis
    Limas Kupcinskas
    Department of Gastroenterology, Kaunas University of Medicine, Kaunas, Lithuania
    Eur J Gastroenterol Hepatol 22:1189-95. 2010
    ..Here, IL1B and IL1RN polymorphisms were analyzed as genotypes and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal metaplasia in the stomach...
  33. ncbi Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint
    N Kiga
    Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Japan
    Eur J Histochem 55:e11. 2011
    ..05). These results indicate that lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 β...
  34. ncbi Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...
  35. ncbi Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon
    A Nath
    Departments of Neurology, Microbiology, and Immunology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    J Biol Chem 274:17098-102. 1999
    ..Hence cross-sectional measurement of viral load in the brain may not be a useful indicator of the role of viral products in the neuropathogenesis of HIV dementia...
  36. ncbi Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma
    Vivek Sharma
    National Brain Research Centre, Manesar, Haryana, 122 050, India
    J Mol Med (Berl) 89:123-36. 2011
    ....
  37. ncbi Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    ....
  38. ncbi IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
    Rana Al-Sadi
    Department of Internal Medicine, MSC10 5550, University of New Mexico School of Medicine, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87131 0001, USA
    Am J Pathol 177:2310-22. 2010
    ..In conclusion, our data show for the first time that MEKK-1 plays an integral role in IL-1β modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-κB pathway and the MLCK gene...
  39. ncbi Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 13:161-72. 2002
    ..In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion...
  40. ncbi Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion
    Christine E Becker
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Biol Chem 284:34531-7. 2009
    ..Altogether, our findings show that Rab39a interacts with caspase-1 and suggest that Rab39a functions as a trafficking adaptor linking caspase-1 to IL-1beta secretion...
  41. ncbi Quantitative gene expression of cytokines in peripheral blood leukocytes stimulated in vitro: modulation by the anti-tumor nerosis factor-alpha antibody infliximab and comparison with the mucosal cytokine expression in patients with ulcerative colitis
    Federico Moriconi
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg August University, Gottingen, Germany
    Transl Res 150:223-32. 2007
    ..The in vitro model of PHA-stimulated PBLs may mimic inflammation processes observed in vivo. INFL may reduce inflammation in vivo through inhibition of both monocyte and T-cell activation...
  42. ncbi Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men
    Jaro Karppinen
    Finnish Institute of Occupational Health, Helsinki, Finland
    Eur Spine J 18:1963-70. 2009
    ..This observation is in accordance with the previous finding from a different geographical area, and thus confirms the importance of the IL1A gene in the pathophysiology of Modic changes...
  43. ncbi Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression
    Andre Tadic
    Department of Psychiatry, University of Mainz Germany
    Neuropsychiatr Dis Treat 4:269-76. 2008
    ..An independent replication of our finding is needed. If replicated, the IL-1beta C-511T promoter polymorphism could be considered useful for prospective confirmatory pharmacogenetic trials in patients with major depression...
  44. ncbi IL-1 beta enhances CD40 ligand-mediated cytokine secretion by human dendritic cells (DC): a mechanism for T cell-independent DC activation
    Thomas Luft
    Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    J Immunol 168:713-22. 2002
    ..The synergy between CD40L and IL-1beta highlights a potent, T cell-independent mechanism for DC activation during the earliest stages of inflammatory responses...
  45. ncbi Polymorphisms in interleukin-1beta and interleukin-1 receptor antagonist genes and malaria in Ghanaian children
    B Gyan
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Scand J Immunol 56:619-22. 2002
    ..01). The mean parasitaemia in an age-matched asymptomatic group did not reveal such associations. These data suggest that IL-1beta exon 5 allele 2 may play a possible role in the clinical outcome of uncomplicated malaria...
  46. ncbi The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression
    Bernhard T Baune
    Department of Psychiatry and Psychiatric Neuroscience, James Cook University, Queensland, Australia
    Biol Psychiatry 67:543-9. 2010
    ..This study investigated the association between genetic variants of the interleukin 1 beta (IL1B) gene and amygdala and ACC responsiveness to emotional stimuli and response to antidepressant treatment...
  47. ncbi Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis
    Xiaoan Liu
    Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Breast Cancer Res Treat 124:821-5. 2010
    ..49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk...
  48. ncbi Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders...
  49. ncbi Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells
    Karen Manon Lammers
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinic S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    FEMS Immunol Med Microbiol 38:165-72. 2003
    ..Total bacterial DNA from feces collected after probiotic administration modulated the immune response by a decrease of interleukin-1 beta and an increase of interleukin-10...
  50. ncbi Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways
    Tao Lu
    Department of Molecular Genetics, Lerner Research Institute, and Brain Tumor Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:4365-70. 2007
    ....
  51. ncbi Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability
    Nathalie Didier
    Commissariat a l Energie Atomique CEA, Service de Pharmacologie et d Immunologie, Saclay, France
    J Neurochem 86:246-54. 2003
    ..Taken together, these results provide evidence for paracrine actions involving ET-1, TNF-alpha and IL-1beta between human astrocytes and BMVECs, which may play a central role in BBB breakdown during CNS inflammation...
  52. ncbi Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro
    L Iacoviello
    Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Arterioscler Thromb Vasc Biol 25:222-7. 2005
    ..To investigate the role of interleukin-1beta (IL-1beta) gene polymorphisms as a link between inflammation, coagulation, and risk of ischemic vascular disease at young age...
  53. ncbi Topological frustration and the folding of interleukin-1 beta
    Shachi Gosavi
    Center for Theoretical Biological Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
    J Mol Biol 357:986-96. 2006
    ..Complex folds like the beta-trefoil fold and functional loops like the beta-bulge of IL-1beta can make some of the configuration space unavailable to the protein and cause topological frustration...
  54. ncbi Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    L Deng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cell 103:351-61. 2000
    ..These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains...
  55. ncbi Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Eur Cytokine Netw 16:253-60. 2005
    ..We designed a broad study to investigate the susceptibility and prognostic implications of the genetic variation in IL-1alpha, IL-1beta and IL-6 in breast carcinoma...
  56. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  57. ncbi Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 205:3145-58. 2008
    ....
  58. ncbi ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
    ..Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion...
  59. ncbi Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: a metaanalysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1 ga, Anam Dong, Seongbuk gu, Seoul, 136 705, Korea
    J Rheumatol 36:12-5. 2009
    ..To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA)...
  60. ncbi Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis
    Dulciene Maria Magalhães Queiroz
    Laboratory of Research in Bacteriology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Inflamm Bowel Dis 15:353-8. 2009
    ..Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population...
  61. ncbi TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages
    Federica Alciato
    Clinical Immunology, Department of Clinical and Experimental Medicine, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    J Leukoc Biol 87:869-75. 2010
    ..Therefore, GAS6 modulates macrophage cytokine secretion, triggering an "anti-inflammatory pathway" involving PI3K/Akt/GSK3 beta and NF-kappaB...
  62. ncbi Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells
    Takahiro Okumura
    Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan
    J Atheroscler Thromb 13:38-45. 2006
    ..In conclusion, chylomicron remnants stimulated IL-1beta mRNA expression and IL-1beta protein production probably via caspase-1 and NF-kappaB activation in THP-1 cells...
  63. ncbi A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis
    Pascal Richette
    Universite Paris 7, UFR médicale, Assistance Publique Hopitaux de Paris, Paris, France
    J Rheumatol 35:1650-4. 2008
    ....
  64. ncbi Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder
    S Papiol
    J Med Genet 41:219-23. 2004
  65. ncbi Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, Genova, Italy
    J Immunol 183:1456-62. 2009
    ..Thus, PAMP-induced ROS trigger an antioxidant response involving intracellular redox enzymes and release of cysteine, ultimately required for IL-1beta processing and secretion...
  66. ncbi IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin
    Meenakshi Chakravorty
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S C Mullick Road, Kolkata, India
    Int J Biochem Cell Biol 41:1502-10. 2009
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression...
  67. ncbi Clinical relevance of IL-1beta promoter polymorphisms (-1470, -511, and -31) in patients with major trauma
    Ai qing Wen
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, P R China
    Shock 33:576-82. 2010
    ..It may be possible to use these polymorphisms as relevant risk estimates for sepsis in trauma patients...
  68. ncbi Interleukin 1alpha, interleukin 1beta and interleukin 1 receptor gene polymorphisms in psoriatic arthritis
    J S Ravindran
    Royal National Hospital for Rheumatic Diseases, Bath, UK
    Rheumatology (Oxford) 43:22-6. 2004
    ..To investigate polymorphisms of interleukin (IL) 1alpha, IL-1beta and IL-1 receptor R1 genes in patients with psoriatic arthritis (PsA), their relationship to the age of onset of psoriasis and the pattern of joint involvement...
  69. ncbi Identification of alpha 2-macroglobulin as a cytokine binding plasma protein. Binding of interleukin-1 beta to "F" alpha 2-macroglobulin
    W Borth
    Institute of Immunology, University of Vienna, Austria
    J Biol Chem 264:5818-25. 1989
    ....
  70. ncbi Interleukin -1beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor (TNF) in plasma and pleural fluid of pneumonia, lung cancer and tuberculous pleuritis
    G Ilonidis
    Fourth Internal Medicine Clinic, Hippokration Hospital, Aristotle University of Thessaloniki, Greece
    J Biol Regul Homeost Agents 20:41-6. 2006
    ..33, 49.94, 21.27 pg/ml and 14, 56.59, 23.58 pg/ml. In conclusion, IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status...
  71. ncbi Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis
    W M Howell
    The Pancreatic and Liver Fibrosis Research Groups, Divisions of Human Genetics, Allergy and Repair, University of Southampton, Southampton SO16 6YD, UK
    J Clin Pathol 58:595-9. 2005
    ....
  72. ncbi Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer
    Meenakshi Chakravorty
    Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata, India
    Hum Mutat 27:411-9. 2006
    ..They also suggest that the allelic interaction between the -511 and -31 polymorphic sites determines the overall strength of the IL1B promoter...
  73. ncbi Induction of interleukin-1 and glucocorticoid hormones by HIV promotes viral replication and links human chromosome 2 to AIDS pathogenesis: genetic mechanisms and therapeutic implications
    P A Corley
    Med Hypotheses 48:415-21. 1997
    ..IL-1 also adversely affects acquired immune deficiency syndrome-related Kaposi's sarcoma. Several genetic treatments for human immunodeficiency virus infection are proposed...
  74. ncbi The association between the interleukin-1 polymorphisms and gastric cancer risk depends on the family history of gastric carcinoma in the study population
    Teresa Starzynska
    Department of Gastroenterology, Pomeranian Medical Academy, Szczecin, Poland
    Am J Gastroenterol 101:248-54. 2006
    ..The association between interleukin-1 polymorphisms, H. pylori and increased gastric cancer risk remains controversial...
  75. ncbi Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Psychiatry Clin Neurosci 61:364-9. 2007
    ..The results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population...
  76. ncbi HIV-1 envelope glycoprotein 120 regulates brain IL-1beta system and TNF-alpha mRNAs in vivo
    S E Ilyin
    Division of Molecular Biology, School of Life and Health Sciences, University of Delaware, Newark 19716 2590, USA
    Brain Res Bull 44:67-73. 1997
    ....
  77. ncbi Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders
    Virginia L Misener
    Toronto Western Research Institute, University Health Network, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:653-9. 2009
    ..The results do not support the involvement of IL1B as a major factor in genetic risk for early-onset mood disorders...
  78. ncbi Investigation of the interleukin-1 gene cluster polymorphisms in Jordanian patients with chronic and aggressive periodontitis
    Jumana A Karasneh
    Department of Oral Medicine and Oral Surgery, Dental School, Jordan University of Science and Technology, Irbid, Jordan
    Arch Oral Biol 56:269-76. 2011
    ..IL-1 gene polymorphisms have been associated with the IL-1 level. The aim of this study was to investigate if IL-1 gene cluster polymorphisms are associated with chronic (CP) and aggressive (AgP) periodontitis in a Jordanian population...
  79. ncbi Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Anticancer Res 30:505-11. 2010
    ..Polymorphisms of interleukin-1 beta gene (IL1B-511C>T) are considered as risk factor for gastric carcinogenesis, but conflicting data have been reported recently...
  80. ncbi Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status
    Sabina Cauci
    Department of Biomedical Sciences and Technologies, School of Medicine, Universita di Udine, Udine, Italy
    BMC Med Genet 11:29. 2010
    ..Therefore, the IL-1 family cytokine genes are plausible candidate genes for athleticism. We explored whether IL-1 polymorphisms are associated with athlete status in European subjects...
  81. ncbi IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
    G Pan
    Department of Endocrinology, Genentech, Inc, 1 DNA Way, South San Francisco, CA, 94080, USA
    Cytokine 13:1-7. 2001
    ..These findings suggest that IL-1H may be another ligand for the IL-18 receptor and a new player in the inflammatory and immune responses mediated by the IL-18/IL-18R axis...
  82. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  83. ncbi Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
    Mukundan Attur
    Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Ann Rheum Dis 69:856-61. 2010
    ..A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs...
  84. ncbi Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population
    Z S Guo
    Department of Rheumatology, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Int J Immunogenet 37:33-7. 2010
    ..This finding provides strong statistical support for the previously observed relationship and indicates possible association between clinical manifestation and genetic factor...
  85. ncbi HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway
    A Ghorpade
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 141:141-9. 2003
    ..001) and seronegative individuals (p<0.01). We propose that astrocyte expression of FasL may participate in neuronal injury in HAD...
  86. ncbi High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
    Isabel García-Arnandis
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Arthritis Res Ther 12:R165. 2010
    ..We have recently reported that HMGB1 is released by osteoarthritic synoviocytes after activation with interleukin-1beta (IL-1β) The present study investigated the role of HMGB1 in synovial inflammation in osteoarthritis (OA)...
  87. ncbi Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes
    Amel M Elshaier
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Rheum 60:143-54. 2009
    ....
  88. ncbi The role of interleukin-1 in wound biology. Part II: In vivo and human translational studies
    Yajing Hu
    Department of Anesthesia, Stanford University, Stanford, USA
    Anesth Analg 111:1534-42. 2010
    ..We further investigate the role of IL-1 in incisional wound biology and its effect on wound chemokine production in vivo and whether this mechanism could be active in human subjects...
  89. ncbi Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence
    F Perri
    Department and Research Laboratory of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
    Cytokine 30:293-302. 2005
    ..An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population...
  90. ncbi Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, London, SE5 9RS, UK
    Int J Gastrointest Cancer 34:19-26. 2003
    ..The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. Genomic DNA was available from 98 patients with HCC, 77 familial controls, 97 controls from Hong Kong and 96 Northern European controls (NECs)...
  91. ncbi Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process
    E J Giamarellos-Bourboulis
    Department of Internal Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Ann Rheum Dis 68:273-8. 2009
    ..In the present study we have investigated whether production of proinflammatory cytokines by crystals was exacerbated during costimulation with Toll-like receptor (TLR) ligands...
  92. ncbi Gene sequence, cDNA construction, expression in Escherichia coli and genetically approached purification of porcine interleukin-1 beta
    K Vandenbroeck
    Rega Institute, University of Leuven, Belgium
    Eur J Biochem 217:45-52. 1993
    A genomic clone (PIL3) covering the 8.8-kb prointerleukin-1 beta ('catabolin') gene of the domesticated swine (Sus scrofa domestica) was isolated from a genomic library and characterized by nucleotide sequencing...
  93. ncbi Regulation of expression of Sertoli cell glucose transporters 1 and 3 by FSH, IL1 beta, and bFGF at two different time-points in pubertal development
    María Noel Galardo
    Centro de Investigaciones Endocrinológicas CEDIE CONICET, Hospital de Ninos Ricardo Gutierrez, Gallo 1330, C1425EDF, Buenos Aires, Argentina
    Cell Tissue Res 334:295-304. 2008
    ..follicle-stimulating hormone (FSH) and by a large set of intratesticular regulators such as interleukin-1 beta (IL1 beta) and basic fibroblast growth factor (bFGF)...
  94. ncbi Effect of recombinant cytokines on glycolysis and fructose 2,6-bisphosphate in rheumatoid synovial cells in vitro
    D J Taylor
    University Department of Medicine, University Hospital of South Manchester, West Didsbury, U K
    Biochem J 250:111-5. 1988
    ..Measurement of Fru(2,6)P2 proved to be the most sensitive parameter for an assessment of glycolysis: IL1 alpha, IL1 beta and IFN-gamma all produced a 3-6-fold increase in this metabolite whereas tumour necrosis factor (TNF alpha) was ..
  95. ncbi Stable inhibition of interleukin 1 receptor type II in Ishikawa cells augments secretion of matrix metalloproteinases: possible role in endometriosis pathophysiology
    S Guay
    Unite d Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec, 10 rue de l Espinay, Local D0 711, Quebec, Canada, G1L 3L5
    Reproduction 134:525-34. 2007
    ..These in vitro data make plausible a role for IL1R2 deficiency in the capability of endometrial cells to invade the host tissue and develop in ectopic locations...
  96. ncbi Single nucleotide polymorphisms of interleukin-1 beta related genes and their associations with infection in the horse
    P Horin
    Institute of Animal Genetics, Faculty of Veterinary Medicine, Brno, Czech Republic
    Dev Biol (Basel) 132:347-51. 2008
    ..A statistically significant association between an intronic SNP of the Casp1 gene with R. equi infection was found. The IL1RN gene was localized to 15q13-q14 in agreement with its originally reported physical position...
  97. ncbi Interleukin 1-beta-induced protein kinase C-zeta activation is mimicked by exogenous phospholipase D
    C Limatola
    Biophysics Laboratory, Centro Ricerca Sperimentale IRE, Rome, Italy
    Biochem J 321:497-501. 1997
    ..These results give the first direct evidence that IL1-beta can activate this atypical PKC isoform and suggest that this enzyme might be involved in mediating some of the biological effects induced by IL1-beta...
  98. ncbi Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration
    A Bakalian
    Institut des Neurosciences, CNRS URA1199, Paris, France
    Res Immunol 143:129-39. 1992
    We recently reported hyperproduction of interleukin-1 (IL1) and hyperexpression of IL1 beta mRNA, after in vitro activation by lipopolysaccharide (LPS) in peripheral macrophages of several neurological mutant mice, i.e...
  99. ncbi Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex
    Krista Hight
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Brain Res 1337:32-40. 2010
    ..of immunoreactive (IR) neurons that stained for tumor necrosis factor alpha (TNFalpha), interleukin-1 beta (IL1 beta), nerve growth factor (NGF), the neuronal nuclear protein (NeuN) and Fos in the rat somatosensory cortex (Sctx) ..
  100. ncbi Arguments for interleukin 1 as a target in chronic arthritis
    W B van den Berg
    Department of Rheumatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Ann Rheum Dis 59:i81-4. 2000
    ..IL1b is not necessarily involved in early joint swelling, but is a crucial mediator in chronic arthritis and cartilage erosion in all models studied so far. This makes ILb an attractive target in chronic, destructive arthritis...
  101. ncbi Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis
    R Bellamy
    Wellcome Trust Centre for Human Genetics, Oxford University, UK
    Tuber Lung Dis 79:83-9. 1998
    ..A study of tuberculosis cases and healthy blood donor controls from the Western Region of The Gambia, West Africa...

Research Grants62

  1. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta. We propose that the transient receptor potential channel TRPA1 is a receptor-operated channel for PGE2, BK and ..
  2. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta. We propose that the transient receptor potential channel TRPA1 is a receptor-operated channel for PGE2, BK and ..
  3. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Silvia S Pierangeli; Fiscal Year: 2010
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  4. Genetic susceptibility to gastric cancer in Latin America
    Eduardo Tarazona Santos; Fiscal Year: 2007
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  5. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona Santos; Fiscal Year: 2010
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  6. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
    ..The detailed description of the expression of these endothelial cell Stx receptors will potentially lead to development of precisely targeted therapies that can reduce Stx toxicity and these devastating effects of HUS/TTP. ..
  7. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
    ..abstract_text> ..
  8. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2006
    ..abstract_text> ..
  9. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
    ..abstract_text> ..
  10. CANDIDA ADHERENCE & PENETRATION OF VASCULAR ENDOTHELIUM
    John Edwards; Fiscal Year: 1993
    ..Additionally, we will elucidate the mechanisms by which activated neutrophils may induce cytoprotective responses in endothelial cells...
  11. Reactivation Tuberculosis in A/J
    Chinnaswamy Jagannath; Fiscal Year: 2005
    ..These studies are anticipated to enhance our understanding on putative mechanisms that precede the reactivation of tuberculosis in the lungs of mice and ultimately help us to develop better strategies to prevent tuberculosis in man. ..
  12. H.pylori, genes and esophageal adenocarcinoma
    Geoffrey Liu; Fiscal Year: 2005
    ..abstract_text> ..
  13. IL-4 Potentiates T Cell Death in Autoimmune Arthritis
    Jian Zhang; Fiscal Year: 2006
    ..studies indicate that IL-4 can promote AICD by down regulating expression of Fas-associated death domain-like IL1 beta-converting enzyme inhibitory protein (FLIP) and up regulating FasL expression, and these effects are achieved via ..
  14. Perinatal infection, cytokines and brain injury
    Zhengwei Cai; Fiscal Year: 2007
    ....
  15. ACCESSORY CELL ACTIVATION OF THE IMMUNE RESPONSE
    PHILIP AURON; Fiscal Year: 2004
    ..abstract_text> ..
  16. Interleukin-1 and Memory Loss in Aging
    Carmelina Gemma; Fiscal Year: 2006
    ....
  17. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  18. RISK GENES IN ALZHEIMERS DISEASE
    M Kamboh; Fiscal Year: 2000
    ..The proposed focused genetic and epidemiological studies will enable us to delineate the role of several candidate genes in further refining and defining the role of genes in determining the risk and natural history of AD. ..