IL-1beta

Summary

Gene Symbol: IL-1beta
Description: interleukin 1, beta
Alias: IL-1, IL1-BETA, IL1F2, IL-1 beta, catabolin, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
Species: human

Top Publications

  1. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
  2. pmc ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
  3. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
  4. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
  5. pmc Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
  6. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
  7. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
  8. pmc Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease
    W Sue T Griffin
    Department of Geriatrics, Medicine, and Psychiatry, University of Arkansas for Medical Sciences, Veterans Affairs Medical Center, Little Rock, USA
    J Leukoc Biol 72:233-8. 2002
  9. ncbi Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    Y D Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 4:155-62. 2001
  10. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008

Research Grants

  1. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
  2. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
  3. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Silvia S Pierangeli; Fiscal Year: 2010
  4. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona Santos; Fiscal Year: 2010
  5. Genetic susceptibility to gastric cancer in Latin America
    Eduardo Tarazona Santos; Fiscal Year: 2007
  6. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
  7. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
  8. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2006
  9. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
  10. CANDIDA ADHERENCE & PENETRATION OF VASCULAR ENDOTHELIUM
    John Edwards; Fiscal Year: 1993

Detail Information

Publications259 found, 100 shown here

  1. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
    ..Thus, the inflammasome constitutes an important arm of the innate immunity...
  2. pmc ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
    ..Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion...
  3. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  4. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  5. pmc Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
    ....
  6. ncbi Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    E M El-Omar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nature 404:398-402. 2000
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not...
  7. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  8. pmc Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease
    W Sue T Griffin
    Department of Geriatrics, Medicine, and Psychiatry, University of Arkansas for Medical Sciences, Veterans Affairs Medical Center, Little Rock, USA
    J Leukoc Biol 72:233-8. 2002
    ..Moreover, this increased risk is associated with earlier age of onset of the disease. Homozygosity for this polymorphism in combination with another in the IL-1B gene further increases risk...
  9. ncbi Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
    Y D Jung
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 4:155-62. 2001
    ..These data demonstrate that IL-1 beta may induce VEGF in hVSMCs, and suggest that this paracrine signaling pathway, may prevent, in part, apoptosis of ECs...
  10. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
    ..Collectively, our results suggest that while TRAF6 autoubiquitination may serve as a marker of activation, it is unlikely to underpin RING finger-dependent TRAF6 function...
  11. ncbi Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection
    Il Ran Hwang
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 123:1793-803. 2002
    ....
  12. pmc Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    Cristina Andrei
    Cell Transport Unit, Department of Oncogenesis, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:9745-50. 2004
    ..This activation is ultimately responsible for lysosome exocytosis and IL-1 beta secretion...
  13. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  14. doi Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?
    Deepti Verma
    Linkoping University, Linkoping, Sweden
    Arthritis Rheum 58:888-94. 2008
    ..We undertook this study to determine whether a patient with arthritis and antibiotic-resistant fever carried mutations in the genes encoding the NALP3 inflammasome...
  15. pmc Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses
    Philip T Liu
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e5810. 2009
    ..Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen...
  16. doi Role of IL-1beta in type 2 diabetes
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:314-21. 2010
    ..To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta...
  17. ncbi Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550 Japan
    Cancer Epidemiol Biomarkers Prev 14:2487-93. 2005
    ..In conclusion, we showed that the IL-8 -251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer...
  18. ncbi Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis
    Selim S Erbek
    Department of Otolaryngology, Faculty of Medicine, Baskent University Konya Teaching and Research Center, Saray Caddesi No 1, Selcuklu Konya, Ankara, Turkey
    Arch Otolaryngol Head Neck Surg 133:705-9. 2007
    ....
  19. pmc Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages
    Matija Hedl
    Department of Internal Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Biol Chem 286:26440-9. 2011
    ..Our findings clarify mechanisms of IL-1β contributions to Nod2 responses and elucidate the dominant role of IL-1β in MDP-initiated MAPK and cytokine secretion...
  20. ncbi A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta:interleukin-1 receptor antagonist balance in atherosclerosis
    Peder S Olofsson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circ J 73:1531-6. 2009
    ..Knowledge of protein levels in atherosclerosis and the influence of a functional IL-1Ra polymorphism would increase the understanding of atherosclerosis pathogenesis...
  21. ncbi Differential binding of proteins to the IL1B -31 T/C polymorphism in lung epithelial cells
    Helge Lind
    Section for Toxicology, Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway
    Cytokine 38:43-8. 2007
    ..Due to the high frequency of this SNP, differences in IL1B gene expression caused by the variants may have significant biological impact in the population...
  22. doi Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection
    Tamia K Lapointe
    Department of Biological Sciences and Inflammation Research Network, University of Calgary, Alberta, Canada
    Cell Microbiol 12:692-703. 2010
    ..pylori disrupts gastric epithelial barrier structure via IL-1RI-dependent activation of ROCK, which in turn mediates tight junctional claudin-4 disruption...
  23. ncbi Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells
    Yong Dae Kim
    Department of Otorhinolaryngology, College of Medicine, Yeungnam University, Nam Gu, Daegu, South Korea
    Mol Pharmacol 62:1112-8. 2002
    ..These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production...
  24. doi Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
    ..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
  25. pmc Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex
    Adel M Nour
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 286:17921-33. 2011
    ..We conclude that NLRP3 inflammasome formation is an innate cellular response to infection with this common pathogenic human herpesvirus...
  26. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..In summary, HuR plays an important role in suppression of TM protein synthesis in IL-1beta treatment and sepsis...
  27. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  28. pmc The rate of interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering
    Sonia Carta
    Cell Biology Unit, National Cancer Research Institute, 16132 Genova, Italy
    J Biol Chem 286:27069-80. 2011
    ..Inflammasome activation by bacterial DNA is not modulated by redox responses, suggesting that redox-dependent regulation of IL-1β secretion is restricted to some inflammasomes including NLRP3 but excluding AIM-2...
  29. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  30. pmc Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    Miyako Okamoto
    Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:6477-88. 2010
    ....
  31. ncbi Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:11802-10. 2002
    ..Interaction between HSF1 and NF-IL6 could thus be an important mechanism in HSF1 regulation of general gene transcription during endotoxin stress...
  32. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  33. ncbi Interleukin 1B gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in Helicobacter pylori-negative gastric cancer of intestinal and diffuse histotype
    A Ruzzo
    Institute of Biochemistry G Fornaini, University of Urbino, Italy
    Ann Oncol 16:887-92. 2005
    ..Available data support an aetiologic role of these genetic variants in the presence of concomitant Helicobacter pylori infection. Their contribution without H. pylori infection is still an open field of investigation...
  34. doi Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study
    Ulla Vogel
    National Research Centre for the Working Environment, DK 2100 Copenhagen O, Denmark
    Mutat Res 639:89-100. 2008
    ..p for interaction was 3 x 10(-6) for COX-2 A-1195G and 9 x 10(-5) for PPARgamma2 Pro(12)Ala. The results suggest that NSAID use may modify risk of lung cancer differently depending on the genotype...
  35. ncbi Involvement of interleukin-1 genotypes in the association of coronary heart disease with periodontitis
    Karen Geismar
    Department of Periodontology, Dental School, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 79:2322-30. 2008
    ..The coexistence of the two disease entities could be dependent on mutual risk factors, and polymorphism of the interleukin (IL)-1 gene cluster associated with the severity of PE might also be involved in the pathogenesis of CHD...
  36. pmc Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
    Jonathan Maelfait
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 205:1967-73. 2008
    ..These results implicate a novel role for caspase-8 in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation...
  37. ncbi Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis
    L M Gomez
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas, CIB, Medellin, Colombia
    Tissue Antigens 67:290-6. 2006
    ..These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1beta in the pathogenesis of mycobacterial infection...
  38. doi The role of the composite interleukin-1 genotype in the association between periodontitis and acute myocardial infarction
    Jamal M Stein
    Department of Operative Dentistry and Periodontology, University Hospital Aachen, Aachen, Germany
    J Periodontol 80:1095-102. 2009
    ..The aim of this study was to evaluate the impact of the composite IL-1 genotype (allele 2 at IL-1A -889 and IL-1B +3954) in the association between acute myocardial infarction (AMI) and periodontitis...
  39. ncbi The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study
    Federico Licastro
    Department of Experimental Pathology, Via S Giacomo 14, 40126 Bologna, Italy
    Mech Ageing Dev 125:575-9. 2004
    ..The administration of anti-inflammatory compounds to middle age healthy subjects with increased genetic susceptibility of developing MI might decrease the incidence and prevalence of cardiovascular events in aging...
  40. ncbi Association of interleukin-1B (IL-1B) gene polymorphisms with risk of gastric cancer in Chinese population
    Wei hua Zhang
    School of Life Science, Lanzhou University, Lanzhou, Gansu, China Department of Gastroenterology, The Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China
    Cytokine 30:378-81. 2005
    ..The results of this study did not support the report that IL-1RN*2+ genotypes were associated with increased risk of GC in Chinese population...
  41. doi The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    Michael Frosch
    University of Muenster, Muenster, Germany
    Arthritis Rheum 60:883-91. 2009
    ..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
  42. doi Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians
    Domingos L S Rios
    Departamento de Ciências da Vida, Universidade do Estado da Bahia UNEB, Campus I, Rua SilveiraMartins, n 2555, ZIP code 41 195 001, Salvador, BA, Brazil
    Cytokine 50:292-6. 2010
    ..This report shows that the IL-1B-511C>T and IL-6-174G>C polymorphisms were associated with CAD risk in African-Brazilians and no association was detected among Caucasian-Brazilians...
  43. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  44. ncbi HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)
    Adelina Holguin
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
    Pain 110:517-30. 2004
    ..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines...
  45. doi Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis
    Liang Liu
    Wuxi Mental Health Center, Nanjing Medical University, Wuxi, China
    Psychiatry Res 176:1-7. 2010
    ..IL-1beta and TNF-alpha may influence the symptoms of schizophrenia in the cognition dysfunction and anxiety/depression domains of the PANSS...
  46. ncbi Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease
    Robert C Read
    Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Ann Intern Med 138:534-41. 2003
    ..Genetically determined variation in proinflammatory cytokine release influences severity of meningococcal disease and other serious infections...
  47. doi Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist
    Omid Khalilzadeh
    Endocrinology and Metabolism Research Center, Vali Asr Hospital, Tehran, Iran
    Clin Experiment Ophthalmol 37:614-9. 2009
    ..This study aimed to investigate the association of GO with single-nucleotide polymorphisms (SNPs) in the IL-1 family (IL-1alpha, IL-1beta, IL-1 receptor [IL-1R] and IL-1 receptor antagonist [IL-1RA])...
  48. ncbi Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human monocyte-derived macrophages
    Ludivine Billiet
    U 545 INSERM, Institut Pasteur de Lille and Université Lille 2, 59019 Lille, France
    J Biol Chem 280:40310-8. 2005
    ..Taken together, these data indicated a potential new mechanism through which extracellular rhTrx-1 exerts an anti-inflammatory function in HMDM...
  49. pmc Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat
    S M Allan
    School of Biological Sciences, 1 124 Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 97:5580-5. 2000
    ....
  50. doi Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis
    Limas Kupcinskas
    Department of Gastroenterology, Kaunas University of Medicine, Kaunas, Lithuania
    Eur J Gastroenterol Hepatol 22:1189-95. 2010
    ..Here, IL1B and IL1RN polymorphisms were analyzed as genotypes and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal metaplasia in the stomach...
  51. doi IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level
    J Sainz
    Unidad de Investigacion, Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Clin Immunol 28:473-85. 2008
    ..The aim of this study was to determine whether interleukin-1 alpha (IL1alpha), interleukin-1 beta (IL1beta), and IL1 receptor antagonist (IL1Ra) polymorphisms are implicated in invasive pulmonary aspergillosis (IPA) pathogenesis...
  52. doi Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma
    Vivek Sharma
    National Brain Research Centre, Manesar, Haryana, 122 050, India
    J Mol Med (Berl) 89:123-36. 2011
    ....
  53. pmc Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
    Catherine M Cahill
    Neurochemistry Laboratory, Department of Psychiatry Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:25900-12. 2008
    ..This novel pathway is a parallel pathway to the PI 3-kinase/AKT upstream of NFkappaB and both are involved in IL-6 gene transcription in response to IL-1...
  54. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  55. pmc IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
    Rana Al-Sadi
    Department of Internal Medicine, MSC10 5550, University of New Mexico School of Medicine, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87131 0001, USA
    Am J Pathol 177:2310-22. 2010
    ..In conclusion, our data show for the first time that MEKK-1 plays an integral role in IL-1β modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-κB pathway and the MLCK gene...
  56. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    ....
  57. pmc Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint
    N Kiga
    Department of Oral and Maxillofacial Surgery, Wakayama Medical University, Japan
    Eur J Histochem 55:e11. 2011
    ..05). These results indicate that lumican and fibromodulin display different behaviors and that lumican may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 β...
  58. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...
  59. ncbi IL-1 beta enhances CD40 ligand-mediated cytokine secretion by human dendritic cells (DC): a mechanism for T cell-independent DC activation
    Thomas Luft
    Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia
    J Immunol 168:713-22. 2002
    ..The synergy between CD40L and IL-1beta highlights a potent, T cell-independent mechanism for DC activation during the earliest stages of inflammatory responses...
  60. ncbi Quantitative gene expression of cytokines in peripheral blood leukocytes stimulated in vitro: modulation by the anti-tumor nerosis factor-alpha antibody infliximab and comparison with the mucosal cytokine expression in patients with ulcerative colitis
    Federico Moriconi
    Department of Internal Medicine, Section of Gastroenterology and Endocrinology, Georg August University, Gottingen, Germany
    Transl Res 150:223-32. 2007
    ..The in vitro model of PHA-stimulated PBLs may mimic inflammation processes observed in vivo. INFL may reduce inflammation in vivo through inhibition of both monocyte and T-cell activation...
  61. pmc Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression
    Andre Tadic
    Department of Psychiatry, University of Mainz Germany
    Neuropsychiatr Dis Treat 4:269-76. 2008
    ..An independent replication of our finding is needed. If replicated, the IL-1beta C-511T promoter polymorphism could be considered useful for prospective confirmatory pharmacogenetic trials in patients with major depression...
  62. pmc Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion
    Christine E Becker
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Biol Chem 284:34531-7. 2009
    ..Altogether, our findings show that Rab39a interacts with caspase-1 and suggest that Rab39a functions as a trafficking adaptor linking caspase-1 to IL-1beta secretion...
  63. doi Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis
    Xiaoan Liu
    Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Breast Cancer Res Treat 124:821-5. 2010
    ..49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk...
  64. doi The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression
    Bernhard T Baune
    Department of Psychiatry and Psychiatric Neuroscience, James Cook University, Queensland, Australia
    Biol Psychiatry 67:543-9. 2010
    ..This study investigated the association between genetic variants of the interleukin 1 beta (IL1B) gene and amygdala and ACC responsiveness to emotional stimuli and response to antidepressant treatment...
  65. ncbi Polymorphisms in interleukin-1beta and interleukin-1 receptor antagonist genes and malaria in Ghanaian children
    B Gyan
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Scand J Immunol 56:619-22. 2002
    ..01). The mean parasitaemia in an age-matched asymptomatic group did not reveal such associations. These data suggest that IL-1beta exon 5 allele 2 may play a possible role in the clinical outcome of uncomplicated malaria...
  66. ncbi Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 13:161-72. 2002
    ..In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion...
  67. pmc Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men
    Jaro Karppinen
    Finnish Institute of Occupational Health, Helsinki, Finland
    Eur Spine J 18:1963-70. 2009
    ..This observation is in accordance with the previous finding from a different geographical area, and thus confirms the importance of the IL1A gene in the pathophysiology of Modic changes...
  68. doi Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders...
  69. ncbi Interleukin-1 gene polymorphisms and gastric cancer risk in a high-risk Italian population
    D Palli
    Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center CSPO, Scientific Institute of Tuscany, Florence, Italy
    Am J Gastroenterol 100:1941-8. 2005
    ..The aim of the study was to investigate the relationship between selected IL1 loci polymorphisms and gastric cancer risk in an Italian population...
  70. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ....
  71. ncbi Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon
    A Nath
    Departments of Neurology, Microbiology, and Immunology, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    J Biol Chem 274:17098-102. 1999
    ..Hence cross-sectional measurement of viral load in the brain may not be a useful indicator of the role of viral products in the neuropathogenesis of HIV dementia...
  72. ncbi Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis
    Beata Hutyrova
    Departments of Immunology, Biology, and Respiratory Medicine, Palacky University, Olomouc, Czech Republic
    Am J Respir Crit Care Med 165:148-51. 2002
    ..Further population studies are warranted to confirm the observed association between sarcoidosis and the IL-1alpha polymorphism and also to explore mechanisms of IL-1alpha -889 participation in aberrant immune response in sarcoidosis...
  73. doi Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3
    Karolin Meixenberger
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 184:922-30. 2010
    ..In addition, an LLO-dependent but cathepsin B-independent NLRP3 activation might contribute to some extent to the IL-1beta production in L. monocytogenes-infected cells...
  74. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
    ....
  75. ncbi De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  76. ncbi Helicobacter pylori infection in combination with the serum pepsinogen I/II ratio and interleukin-1beta-511 polymorphisms are independent risk factors for gastric cancer in Thais
    Sirikan Yamada
    Division of Gastrointestinal Surgery and Endoscopy, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Gastroenterol 41:1169-77. 2006
    ..Thailand has the lowest incidence of gastric cancer in the world. Helicobacter pylori infection, a low serum pepsinogen I/II ratio, and interleukin (IL)-1beta-511 polymorphisms are suspected to be risk factors for gastric cancer...
  77. ncbi Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability
    Nathalie Didier
    Commissariat a l Energie Atomique CEA, Service de Pharmacologie et d Immunologie, Saclay, France
    J Neurochem 86:246-54. 2003
    ..Taken together, these results provide evidence for paracrine actions involving ET-1, TNF-alpha and IL-1beta between human astrocytes and BMVECs, which may play a central role in BBB breakdown during CNS inflammation...
  78. ncbi Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro
    L Iacoviello
    Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Arterioscler Thromb Vasc Biol 25:222-7. 2005
    ..To investigate the role of interleukin-1beta (IL-1beta) gene polymorphisms as a link between inflammation, coagulation, and risk of ischemic vascular disease at young age...
  79. pmc Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways
    Tao Lu
    Department of Molecular Genetics, Lerner Research Institute, and Brain Tumor Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:4365-70. 2007
    ....
  80. ncbi Topological frustration and the folding of interleukin-1 beta
    Shachi Gosavi
    Center for Theoretical Biological Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
    J Mol Biol 357:986-96. 2006
    ..Complex folds like the beta-trefoil fold and functional loops like the beta-bulge of IL-1beta can make some of the configuration space unavailable to the protein and cause topological frustration...
  81. ncbi Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells
    Karen Manon Lammers
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinic S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    FEMS Immunol Med Microbiol 38:165-72. 2003
    ..Total bacterial DNA from feces collected after probiotic administration modulated the immune response by a decrease of interleukin-1 beta and an increase of interleukin-10...
  82. ncbi Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    L Deng
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cell 103:351-61. 2000
    ..These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains...
  83. ncbi Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese
    Michael A Heneghan
    Institute of Liver Studies, King s College Hospital, London, SE5 9RS, UK
    Int J Gastrointest Cancer 34:19-26. 2003
    ..The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. Genomic DNA was available from 98 patients with HCC, 77 familial controls, 97 controls from Hong Kong and 96 Northern European controls (NECs)...
  84. ncbi A new nomenclature for IL-1-family genes
    J E Sims
    Trends Immunol 22:536-7. 2001
  85. ncbi Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis
    M Constanza Camargo
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, 2215 Garland Avenue, 1005 MRB IV, Nashville, TN 37232 0252, USA
    Cancer Epidemiol Biomarkers Prev 15:1674-87. 2006
    ..Polymorphisms of interleukin-1B (IL1B) and its receptor antagonist (IL1RN) genes have been inconsistently associated with gastric cancer risk. We examined these associations by performing meta-analyses...
  86. pmc Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China
    Z R Zeng
    First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou, China
    Gut 52:1684-9. 2003
    ..Our aim was to study the relationship between interleukin 1B (IL-1B) polymorphism, Helicobacter pylori infection, and gastric cancer in high prevalent (Shanxi) and low prevalent (Guangdong) regions in China...
  87. ncbi Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery
    Mehmet R Genc
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, USA
    Am J Obstet Gynecol 187:157-63. 2002
    ..We examined the association between preterm delivery and polymorphisms at position +3953 of the interleukin-1 beta gene (IL1B+3953) and in intron 2 of the interleukin-1 receptor antagonist gene (IL1RN)...
  88. ncbi The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  89. pmc High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
    Isabel García-Arnandis
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Arthritis Res Ther 12:R165. 2010
    ..We have recently reported that HMGB1 is released by osteoarthritic synoviocytes after activation with interleukin-1beta (IL-1β) The present study investigated the role of HMGB1 in synovial inflammation in osteoarthritis (OA)...
  90. ncbi Genetic differences in interleukin-1 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H. pylori infection and gastric cancer incidence
    N Matsukura
    First Dept of Surgery, Nippon Medical School, Tokyo, Japan
    J Exp Clin Cancer Res 22:47-55. 2003
    ..IL-1betapolymorphisms were correlated with mucosal atrophy in the Japanese and Chinese populations, but not in the Thai and Vietnamese populations...
  91. ncbi HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway
    A Ghorpade
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 141:141-9. 2003
    ..001) and seronegative individuals (p<0.01). We propose that astrocyte expression of FasL may participate in neuronal injury in HAD...
  92. ncbi A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    Jose Carlos Machado
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, S N, 4200 465 Porto, Portugal
    Gastroenterology 125:364-71. 2003
    ..We also investigated the extent to which the combined effect of proinflammatory genetic polymorphisms (IL-1B, IL-1RN, and TNF-alpha), and the combined effect of TNF-alpha and bacterial genotypes each influence such a risk...
  93. pmc Allelic variation at the interleukin 1beta gene is associated with decreased bone mass in patients with inflammatory bowel diseases
    A Nemetz
    2nd Department of Medicine, Semmelweis University, Budapest, Hungary
    Gut 49:644-9. 2001
    ..Both cytokines influence bone formation. IL-1beta stimulates osteoclast activity while interleukin 1 receptor antagonist (IL-1ra) enhances bone formation...
  94. pmc Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 205:3145-58. 2008
    ....
  95. doi Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis
    Dulciene Maria Magalhães Queiroz
    Laboratory of Research in Bacteriology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Inflamm Bowel Dis 15:353-8. 2009
    ..Our aim was to investigate associations among IL1B-511, IL1B-31, IL1RN, TNFA-307, TLR-2, TLR-4, IL2-330, NOD2 G908R, NOD2 L1007fsinsC polymorphisms and both Crohn's disease (CD) and ulcerative colitis (UC) in a Brazilian population...
  96. doi Association between interleukin 1 polymorphisms and rheumatoid arthritis susceptibility: a metaanalysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1 ga, Anam Dong, Seongbuk gu, Seoul, 136 705, Korea
    J Rheumatol 36:12-5. 2009
    ..To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA)...
  97. ncbi A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis
    Pascal Richette
    Universite Paris 7, UFR médicale, Assistance Publique Hopitaux de Paris, Paris, France
    J Rheumatol 35:1650-4. 2008
    ....
  98. ncbi Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells
    Takahiro Okumura
    Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan
    J Atheroscler Thromb 13:38-45. 2006
    ..In conclusion, chylomicron remnants stimulated IL-1beta mRNA expression and IL-1beta protein production probably via caspase-1 and NF-kappaB activation in THP-1 cells...
  99. pmc Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder
    S Papiol
    J Med Genet 41:219-23. 2004
  100. doi IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin
    Meenakshi Chakravorty
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Raja S C Mullick Road, Kolkata, India
    Int J Biochem Cell Biol 41:1502-10. 2009
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression...
  101. doi TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages
    Federica Alciato
    Clinical Immunology, Department of Clinical and Experimental Medicine, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    J Leukoc Biol 87:869-75. 2010
    ..Therefore, GAS6 modulates macrophage cytokine secretion, triggering an "anti-inflammatory pathway" involving PI3K/Akt/GSK3 beta and NF-kappaB...

Research Grants63

  1. Neural Plasticity and Inflammatory Pain
    CLIFFORD WOOLF; Fiscal Year: 2007
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta. We propose that the transient receptor potential channel TRPA1 is a receptor-operated channel for PGE2, BK and ..
  2. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2010
    ..that peripheral and central sensitization are both driven by the inflammatory mediators PGE2, bradykinin and IL1 beta. We propose that the transient receptor potential channel TRPA1 is a receptor-operated channel for PGE2, BK and ..
  3. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Silvia S Pierangeli; Fiscal Year: 2010
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  4. Genetic susceptibility to gastric cancer in Latin America
    Eduardo M Tarazona Santos; Fiscal Year: 2010
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  5. Genetic susceptibility to gastric cancer in Latin America
    Eduardo Tarazona Santos; Fiscal Year: 2007
    ..By performing the study in Lima and Rio de Janeiro, we address the key issue of replication of genetic association studies. ..
  6. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
    ..The detailed description of the expression of these endothelial cell Stx receptors will potentially lead to development of precisely targeted therapies that can reduce Stx toxicity and these devastating effects of HUS/TTP. ..
  7. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
    ..abstract_text> ..
  8. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2006
    ..abstract_text> ..
  9. Conjunctival Mast Cells in Allergic Eye Disease
    NEAL BARNEY; Fiscal Year: 2003
    ..abstract_text> ..
  10. CANDIDA ADHERENCE & PENETRATION OF VASCULAR ENDOTHELIUM
    John Edwards; Fiscal Year: 1993
    ..Additionally, we will elucidate the mechanisms by which activated neutrophils may induce cytoprotective responses in endothelial cells...
  11. Reactivation Tuberculosis in A/J
    Chinnaswamy Jagannath; Fiscal Year: 2005
    ..These studies are anticipated to enhance our understanding on putative mechanisms that precede the reactivation of tuberculosis in the lungs of mice and ultimately help us to develop better strategies to prevent tuberculosis in man. ..
  12. H.pylori, genes and esophageal adenocarcinoma
    Geoffrey Liu; Fiscal Year: 2005
    ..abstract_text> ..
  13. IL-4 Potentiates T Cell Death in Autoimmune Arthritis
    Jian Zhang; Fiscal Year: 2006
    ..studies indicate that IL-4 can promote AICD by down regulating expression of Fas-associated death domain-like IL1 beta-converting enzyme inhibitory protein (FLIP) and up regulating FasL expression, and these effects are achieved via ..
  14. Perinatal infection, cytokines and brain injury
    Zhengwei Cai; Fiscal Year: 2007
    ....
  15. ACCESSORY CELL ACTIVATION OF THE IMMUNE RESPONSE
    PHILIP AURON; Fiscal Year: 2004
    ..abstract_text> ..
  16. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  17. Interleukin-1 and Memory Loss in Aging
    Carmelina Gemma; Fiscal Year: 2006
    ....
  18. RISK GENES IN ALZHEIMERS DISEASE
    M Kamboh; Fiscal Year: 2000
    ..The proposed focused genetic and epidemiological studies will enable us to delineate the role of several candidate genes in further refining and defining the role of genes in determining the risk and natural history of AD. ..