IL-13

Summary

Gene Symbol: IL-13
Description: interleukin 13
Alias: IL-13, P600, interleukin-13
Species: human

Top Publications

  1. ncbi Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 112:382-8. 2003
  2. ncbi A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
    Min Wang
    Department of ENT, People s Hospital, Peking University, 11 Xi Zhi Men Nan Da Jie, 100044, Beijing, P R China
    Hum Genet 113:387-90. 2003
  3. ncbi Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma
    Sergey Ryzhov
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, 1500 21st Avenue South, Nashville, TN 37232, USA
    J Immunol 172:7726-33. 2004
  4. pmc Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences
    T R D J Radstake
    Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:1737-43. 2005
  5. pmc Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF
    Sima Allahverdian
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 38:153-60. 2008
  6. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  7. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
  8. doi Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark
    Pediatr Allergy Immunol 20:614-23. 2009
  9. pmc Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness
    Takachika Ito
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Biol Chem 284:24289-96. 2009
  10. doi Association of interleukin-13 C-1112T and G+2044A polymorphisms with asthma: a meta-analysis
    Haijun Yang
    National Institute for Occupational Health and Poison Control, Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing, China
    Respirology 16:1127-35. 2011

Research Grants

  1. IL8 and GATA3-mediated Pathways in Asthma Exacerbations
    Fernando Martinez; Fiscal Year: 2007
  2. Gutless Adenovirus Mediated Targeted Therapeutics for Glioma
    Marianela Candolfi; Fiscal Year: 2007
  3. Biomarkers of survival in glioma epidemiology
    John Wiencke; Fiscal Year: 2009
  4. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2007
  5. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2009
  6. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2011
  7. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2011
  8. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2010
  9. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
  10. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010

Detail Information

Publications211 found, 100 shown here

  1. ncbi Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 112:382-8. 2003
    ....
  2. ncbi A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
    Min Wang
    Department of ENT, People s Hospital, Peking University, 11 Xi Zhi Men Nan Da Jie, 100044, Beijing, P R China
    Hum Genet 113:387-90. 2003
    ..b>Interleukin 13 (IL-13) has been implicated in the pathogenesis and in the regulation of immunoglobulin E (IgE) production...
  3. ncbi Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma
    Sergey Ryzhov
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, 1500 21st Avenue South, Nashville, TN 37232, USA
    J Immunol 172:7726-33. 2004
    ....
  4. pmc Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences
    T R D J Radstake
    Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Ann Rheum Dis 64:1737-43. 2005
    ..Dendritic cell (DC) function is largely tailored by Fc gamma receptors (Fc gamma R) and is critical for every immune response...
  5. pmc Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF
    Sima Allahverdian
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 38:153-60. 2008
    ..Dysregulation of EGFR phosphorylation may contribute to a persistent repair phenotype and chronically increased IL-13 release, and in turn result in airway remodeling...
  6. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  7. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  8. doi Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark
    Pediatr Allergy Immunol 20:614-23. 2009
    ..Polymorphisms in IL-8 affected the association between pet-keeping and risk of wheeze. Polymorphisms in inflammation genes might affect the association between environmental exposures and risk of recurrent wheeze in early childhood...
  9. pmc Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness
    Takachika Ito
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Biol Chem 284:24289-96. 2009
    ..These results demonstrate that the D1 domain of IL-13Ralpha1 acts as an affinity converter, through direct cytokine interactions, that allows the shared receptor to respond differentially to IL-4 and IL-13...
  10. doi Association of interleukin-13 C-1112T and G+2044A polymorphisms with asthma: a meta-analysis
    Haijun Yang
    National Institute for Occupational Health and Poison Control, Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing, China
    Respirology 16:1127-35. 2011
    ..However, a number of studies have shown inconsistent results. A meta-analysis was performed to investigate whether polymorphisms in the IL13 gene were associated with the risk of asthma...
  11. doi Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children
    I H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Allergy 63:1031-9. 2008
    ..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into the pathophysiology of asthma...
  12. doi Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma
    Renske W B Bottema
    Department of Pulmonology, University Medical Center, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 153:259-67. 2010
    ..IL13 and IL4R polymorphisms are associated with asthma and show gene-gene interaction in asthma. Their role in rhinitis has not been extensively studied...
  13. ncbi A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Immun 4:528-31. 2003
    ..An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production...
  14. ncbi Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  15. doi Association and gene-gene interactions of eight common single-nucleotide polymorphisms with pediatric asthma in middle china
    Xiaohui Wu
    Department of Clinical Laboratory, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Asthma 47:238-44. 2010
    ..Asthma is a common polygenic disease, caused by complex interactions between multiple genes and environmental factors. Study of the gene-gene interactions would contribute to a new insight into the pathogenesis and therapeutics of asthma...
  16. doi Several interleukin-4 and interleukin-13 gene single nucleotide polymorphisms among Chinese asthmatic patients
    Peng Jiang
    Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
    Allergy Asthma Proc 30:413-8. 2009
    ..Asthma is largely determined by the accumulation of several certain genetic variations other than one or two SNPs. Future function studies may be able to help us reveal the significance of genetic variants we identified in this study...
  17. doi A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2
    J Genuneit
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Clin Exp Allergy 39:1875-88. 2009
    ..We investigated their associations with wheeze and allergy in a case-control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood...
  18. pmc Association of the gene polymorphisms IFN-gamma +874, IL-13 -1055 and IL-4 -590 with patterns of reinfection with Schistosoma mansoni
    Michael R Gatlin
    University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 3:e375. 2009
    ....
  19. ncbi Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis
    Jeong Joong Kim
    Department of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Eur Arch Otorhinolaryngol 264:395-9. 2007
    ..Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Ralpha Gln551Arg polymorphism is not related to allergic rhinitis...
  20. ncbi Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma
    Kazuhiko Arima
    Department of Biochemistry, Saga Medical School, Saga, Japan
    J Allergy Clin Immunol 109:980-7. 2002
    ..We recently found that a variant of the IL13 gene (Arg110Gln) is genetically associated with bronchial asthma, which is concordant with animal experiments using IL-13 in the development of asthma...
  21. ncbi Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans
    Ioannis Moissidis
    Allergy and Immunology Section, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Genet Med 7:406-10. 2005
    ..We studied these SNPs in African Americans with asthma and/or atopy...
  22. ncbi Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma
    Hyo Bin Kim
    Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong Songpa gu, and Hangang Sacred Heart Hospital, Seoul, 138 736, Korea
    J Hum Genet 51:1055-62. 2006
    ..002, 0.010). These findings indicate that the IL-13 G+2044A is associated with asthma development and the IL-13 and IL-13Ralpha1 polymorphisms may interact to enhance IgE production...
  23. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...
  24. doi Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
    ..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...
  25. ncbi Genetic variants of IL-13 signalling and human asthma and atopy
    A Heinzmann
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Hum Mol Genet 9:549-59. 2000
    ..38 in males, 1.10 in females) rather than asthma. Thus, certain variants of IL-13 signalling are likely to be important promoters of human asthma; detailed functional analysis of their actions is needed...
  26. pmc IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study
    Alireza Sadeghnejad
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Respir Res 9:2. 2008
    ..The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma...
  27. doi Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes
    Elena Llanes
    Servicio de Inmunologia, Fundacion Jimenez Diaz Capio, CIBERES ISCIII, Madrid, Spain
    Int Arch Allergy Immunol 148:228-38. 2009
    ....
  28. doi Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort
    S Black
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London NW1 2HE, UK
    Allergy 64:1172-8. 2009
    ....
  29. doi Association of rs7719175, located in the IL13 gene promoter, with Schistosoma haematobium infection levels and identification of a susceptibility haplotype
    A Isnard
    INSERM, U906, Marseille, France
    Genes Immun 12:31-9. 2011
    ..Polymorphisms rs7719175 and rs1800925 have a synergistic role in the control of infection levels caused by S. haematobium and using them as a haplotype allows a better discrimination between infected subjects...
  30. doi Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation
    Ynuk Bosse
    Immunology Division, Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Canada
    Int Arch Allergy Immunol 146:138-48. 2008
    ..In addition, the effects of the proinflammatory mediators TNFalpha and IL-1 beta and the involvement of members of the well-known family of platelet-derived growth factor (PDGF) mitogens were tested...
  31. doi Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Hirokoji, Kawaramachi, Kamigyoku, Kyoto, Japan
    Invest Ophthalmol Vis Sci 49:1809-13. 2008
    ..To examine IL-4 and IL-13 gene polymorphisms and the combination of these polymorphisms with IL-4R polymorphism, the authors performed polymorphism analysis...
  32. ncbi T cells and mast cells as a major source of interleukin-13 in atopic dermatitis
    Wataru Obara
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    Dermatology 205:11-7. 2002
    ..Recent studies suggest that cytokines expressed locally in the skin play several critical roles in atopic dermatitis (AD), however, little is known about the role of IL-13 in AD lesions...
  33. ncbi [Correlation of IL-4 and IL-13 gene polymorphisms with asthma and total serum IgE levels]
    Xiu Hai Wang
    Department of Biology, Qingdao University Medical College, Qingdao 266021, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:161-4. 2009
    ....
  34. doi An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population
    Jiu Yao Wang
    Department of Pediatrics and Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Immunol 29:205-9. 2009
    ..Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform...
  35. ncbi Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones
    Jean Pierre Bayley
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:2142-8. 2003
    ..The gene for IL-4 showed an imbalance in expression from each allele, indicating differential expression of IL-4 alleles within or between IL-4-expressing cells...
  36. ncbi Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population
    Xue xi YANG
    School of Biotechnology, Southern Medical University, Guangzhou, China
    Asian Pac J Allergy Immunol 29:273-7. 2011
    ..Asthma is a common respiratory disease caused by genetic and environmental factors. It has been suggested that TGF-beta1, IL-4 and IL-13 play important roles in asthma...
  37. doi The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico
    Balam Muñoz
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico, DF 07360, Mexico
    Environ Toxicol Pharmacol 33:226-32. 2012
    ..No association among ETS exposure, asthma, and the studied polymorphisms was denoted by multivariate analysis of this population...
  38. ncbi Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin
    Kazuyuki Chibana
    Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi, Japan
    J Immunol 170:4290-5. 2003
    ..In the Th2 cytokine-rich milieu, such as that in bronchial asthma, CysLT1R expression on fibroblasts might be up-regulated, thereby allowing CysLTs to act effectively and increase eosinophilic inflammation...
  39. doi Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: a meta-analysis based on 1,411 cases and 3169 controls
    Xinjiang Ying
    Department of Otolaryngology, Huadong Hospital, Fudan University, 221 Yan An Xi Road, Shanghai 200040, China
    Gene 506:179-83. 2012
    ..29; T/T versus C/C: OR=1.00, 95% CI=0.69-1.44; C/T+T/T versus CC: OR=1.10, 95% CI=0.96-1.27; T/T versus C/C+C/T: OR=0.91, 95% CI=0.64-1.31). This meta-analysis supported that IL-13 SNP rs1800925 was not associated with allergic rhinitis...
  40. ncbi [Correlation of interleukin-13 gene - 1112c/T polymorphism with asthma and total plasma IgE levels]
    Bin Wu
    Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:668-71. 2004
    ..To investigate the correlation of - 1112C/T polymorphism of Interleukin-13 (IL-13) gene promoter with asthma and its effect on total plasma IgE levels...
  41. ncbi Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Allergy Clin Immunol 120:91-7. 2007
    ..Recently a polymorphic variant of IL-13 (R110Q) has been shown to be associated with atopy...
  42. doi Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population
    Jung Hyun Namkung
    Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Exp Dermatol 20:915-9. 2011
    ..As IL-13Rα1 is most likely expressed in Th17 cells rather than in Th2 cells, these data suggest diversity in the classification of Th cells that needs to be verified in future studies...
  43. doi Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells
    Masakiyo Nakahira
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 23:761-72. 2011
    ..These findings suggest that Gata3, which is not originally expressed in T(h)1 cells, alters the cytokine production profile by T(h)1 cells...
  44. pmc c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus
    Teruhiko Kozuka
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 187:5974-82. 2011
    ..Therefore, in addition to the strong enhancer effect for the transcription of IL-13, the c-Myb/GATA-3 complex recruits MLL to the CGRE for histone modification of the IL-13 locus during the differentiation of memory Th2 cells...
  45. pmc Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood
    S H Arshad
    The David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight and IIR Research Division, University of Southampton, Southampton, UK
    Br J Dermatol 158:1315-22. 2008
    Atopic eczema is characterized by Th2-dominant immunity with the cytokine interleukin 13 and the transcription factor GATA binding protein 3 playing a critical role.
  46. doi Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2
    Lynne A Murray
    Department of Immunobiology, Centocor Research and Development, 145 King of Prussia Road, Radnor, PA 19087, USA
    Int J Biochem Cell Biol 40:2174-82. 2008
    ..Overall this study demonstrates an interplay between TGFbeta1, IL-13 and CCL2 in IPF/UIP, where these three mediators feedback on each other, promoting the fibrotic response...
  47. ncbi No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis
    Y T Chang
    Department of Dermatology, Tapei Veterans General Hospital, Tapei, Taiwan
    Clin Exp Dermatol 31:419-23. 2006
    ..To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD...
  48. pmc Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort
    Marianne Huebner
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48823, USA
    J Allergy Clin Immunol 121:408-14. 2008
    ..GATA3 activates transcription of the T(H)2 cytokines, including IL13, an important step in the allergic inflammatory pathway...
  49. ncbi Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population
    Lei Cheng
    Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Int Arch Allergy Immunol 139:25-30. 2006
    ..Recent studies revealed that a common variant in the coding region of the IL13 gene, Arg110Gln, has been implicated in the development of asthma and atopy...
  50. ncbi IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation
    Hazel C Atherton
    Novartis Respiratory Research Centre, Wimblehurst Rd, Horsham, West Sussex RH12 5AB, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 285:L730-9. 2003
    ..These data support the concept that IL-13 is in part able to induce a mucus hypersecretory phenotype through a direct interaction with the airway epithelium and that MAP kinase and PtdIns 3-kinase signaling pathways are involved...
  51. pmc Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos
    Teodorica L Bugawan
    Roche Molecular Systems, Alameda, CA 94501, USA
    Am J Hum Genet 72:1505-14. 2003
    ..Our data suggest that the risk for T1D is determined, in part, by polymorphisms within the IL4R locus, including promoter and coding-sequence variants, and by specific combinations of genotypes at the IL4R and the IL4 and IL13 loci...
  52. ncbi Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
    K Wright
    Department of Pharmacology, Bath University, Claverton Down, Bath, Avon BA2 7AY, United Kingdom
    J Biol Chem 272:12626-33. 1997
    ..These data demonstrate that the activation of PtdIns 3-kinase by IL-13 is a key signal that is responsible for the inhibition of iNOS transcription in activated epithelial cells...
  53. ncbi Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica
    J C Celedon
    Channing Laboratory Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Exp Allergy 32:387-90. 2002
    ..Single nucleotide polymorphisms (SNPs) in the IL-13 gene have been associated with asthma and total serum IgE level in Caucasian populations...
  54. doi Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease
    W Zhu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    J Endocrinol Invest 33:751-5. 2010
    ..The aim of the present study is to elucidate whether the single nucleotide polymorphisms (SNP) and the interaction of variants in the 5 genes are associated with the development of GD and Graves' ophthalmopathy (GO)...
  55. ncbi Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:100-7. 2002
    ..This result suggests that 4257A allele is associated with susceptibility to AD and that it may function in the pathogenesis of AD itself, presumably by other mechanisms than inducing IgE production...
  56. ncbi Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  57. ncbi Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections
    Bourema Kouriba
    Department of Epidemiology and Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, and Service of Internal Medicine, National Hospital of Point G, Bamako, Mali
    J Immunol 174:6274-81. 2005
    ..Previous studies on asthma indicated that the IL13-1055T allele increased gene transcription, which is in agreement with the fact that this cytokine enhances resistance to infection by schistosome in humans...
  58. ncbi IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function
    Alireza Sadeghnejad
    Center for Human Genomics and Department of Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 176:748-52. 2007
    ..IL-13 is involved in pulmonary inflammation, remodeling, and susceptibility to chronic obstructive pulmonary disease (COPD)...
  59. ncbi A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Exp Allergy 31:1515-21. 2001
    ..Previous studies showed that polymorphisms in the IL-13 gene were associated with serum total IgE or allergic asthma. The relationship of this marker with sensitization to individual aeroallergens has not been evaluated...
  60. ncbi Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population
    T D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Respir Cell Mol Biol 25:377-84. 2001
    ..Further investigation is required to determine which specific alleles or combination of alleles contribute to these phenotypes, and the possible downstream effects of the resulting change in IL-13 levels or activity...
  61. ncbi A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma
    Michael O Daines
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 277:10387-93. 2002
    ..These results provide the first evidence that the IL-13Ralpha2 is predominantly an intracellular molecule and demonstrate a novel mechanism by which IFN-gamma can regulate IL-13 responses...
  62. pmc IL13 gene polymorphism association with cord serum immunoglobulin E
    Alireza Sadeghnejad
    Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA
    Pediatr Allergy Immunol 18:288-92. 2007
    ..SNP rs1295685 was associated with raised cord serum IgE (p = 0.031). This is the first report that shows an association between IL13 polymorphism and cord serum IgE...
  63. pmc No evidence of association between interleukin-13 gene polymorphism in aspirin intolerant chronic urticaria
    Nami Shrestha Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Allergy Asthma Immunol Res 1:36-40. 2009
    ..05, respectively). Our data lead to the conclusion that there is no evidence supporting genetic polymorphisms in IL-13 as a genetic risk factor for the development of AICU...
  64. pmc Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma
    Natalie C Battle
    University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Am J Respir Crit Care Med 175:881-7. 2007
    ..Furthermore, interaction between these genes has been shown to affect asthma in white and Chinese populations...
  65. ncbi Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma
    Sung Woo Park
    Asthma and AAllergy Research Group, Soonchunhyang University, Bucheon Hospital, 1174, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, 420 021, Korea
    Chest 128:1921-7. 2005
    ..This study evaluated the role of IL-13 in asthma by comparing the sputum IL-5 and IL-13 levels in both groups...
  66. ncbi Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation
    Lisa Cameron
    Functional Genomics Laboratory, and Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    J Immunol 177:8633-42. 2006
    ..Our findings suggest the nuclear milieu dictates the functional outcome of genetic variation...
  67. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
    ..These data suggest that IL-13Ralpha(2) signaling during prolonged inflammation is an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis...
  68. pmc Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function
    A N McKenzie
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104
    Proc Natl Acad Sci U S A 90:3735-9. 1993
    ..Based on these findings, we propose that this immunoregulatory protein be designated interleukin 13.
  69. ncbi Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes
    Beena Puthothu
    University Children s Hospital, University of Freiburg, Germany
    J Infect Dis 193:438-41. 2006
    ..More studies are needed to clarify whether RSV infection provokes asthma or whether RSV infection occurs in children who are genetically predisposed to a pronounced T helper 2 immune response and subsequently develop bronchial asthma...
  70. ncbi Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism
    T C T M van der Pouw Kraan
    Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands
    Genes Immun 3:436-9. 2002
    ..2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD...
  71. ncbi Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression
    D Kaur
    Department of Infection, Institute for Lung Health, Inflammation and Immunity, University of Leicester, Leicester, UK
    Allergy 61:1047-53. 2006
    ..The IL-13 receptor, IL-13Ralpha1, is expressed on most leukocytes, except T-cells. Evidence to support IL-13Ralpha1 expression on mast cells is limited...
  72. pmc IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation
    Frank D Vladich
    Functional Genomics Laboratory, Arizona Respiratory Center and Department of Cell Biology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Clin Invest 115:747-54. 2005
    ..Collectively, our data indicate that natural variation in the coding region of IL13 may be an important genetic determinant of susceptibility to allergy...
  73. ncbi Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis
    Andrea Heinzmann
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    J Allergy Clin Immunol 112:735-9. 2003
    ..Chronic inflammatory disorders can be subdivided by their predominant immune response, either TH1 or TH2. For example, juvenile idiopathic arthritis (JIA) is a TH1 disease, and bronchial asthma is a TH2 disease...
  74. doi Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction
    Mi Jin Kang
    Asan Institute for Life Sciences, University of Ulsan, Poongnap dong Songpa gu, Korea
    Pharmacogenet Genomics 18:551-8. 2008
    ..IL-13 is a pivotal cytokine in allergic inflammation and bronchial hyperresponsiveness, and is known to influence leukotriene levels...
  75. doi Interleukin-13 promoter gene polymorphism -1112C/T is associated with the systemic form of mastocytosis
    B Nedoszytko
    Department of Dermatology, Medical university of Gdańsk Gdańsk, Poland
    Allergy 64:287-94. 2009
    ..Little is known, however, about factors predisposing for the development of SM. One factor may be cytokine regulation of MC progenitors...
  76. ncbi Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
    Sabine Hoffjan
    Department of Human Genetics, University of Chicago, IL 60637, USA
    J Allergy Clin Immunol 113:511-8. 2004
    ..Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the first year that might be early clinical markers of asthma...
  77. ncbi Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 113:489-95. 2004
    ..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors...
  78. ncbi Association of polymorphisms in Th1, Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg
    A Nieters
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Clin Exp Allergy 34:346-53. 2004
    ..Indications exist that polymorphisms in cytokine genes involved in the regulation of the Th1/Th2 balance may contribute to the allergic phenotype...
  79. doi Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: a cross-sectional population-based study in Korea
    Heung Woo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Respir Med 103:284-8. 2009
    ..This study was conducted to evaluate the association between IL13+2044G-->A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function in early childhood...
  80. ncbi Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants
    Weiguo Chen
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 114:553-60. 2004
    ..IL-13 mediates its effects via its receptor, a heterodimer composed of IL-4R alpha and IL-13R alpha1. Polymorphic variants of both IL-13 and IL-4R alpha have been shown to be associated with atopy...
  81. ncbi An IL-13 promoter polymorphism associated with increased risk of allergic asthma
    T C van der Pouw Kraan
    Department of Auto Immune Diseases, CLB and Laboratory of Clinical and Experimental Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Genes Immun 1:61-5. 1999
    ..002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma...
  82. pmc The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
    Farhat Syed
    Centocor Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Respir Res 6:9. 2005
    Growing evidence shows that interleukin 13 (IL-13) may play an essential role in the development of airway inflammation and bronchial hyper-responsiveness (BHR), two defining features of asthma...
  83. doi Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Eur Respir J 32:593-602. 2008
    ..The present study indicates that atopy is importantly influenced by interleukin 13 at age 1-8 yrs and by CD14 in interaction with pet exposure at ages 4 and 8 yrs...
  84. ncbi IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling
    Qingsheng Chen
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 174:2305-13. 2005
    ..When viewed in combination, these studies demonstrate that IL-11Ralpha plays a key role in the pathogenesis of IL-13-induced inflammation and remodeling...
  85. ncbi Serological detection of eotaxin, IL-4, IL-13, IFN-gamma, MIP-1alpha, TARC and IP-10 in chronic autoimmune urticaria and chronic idiopathic urticaria
    Marzia Caproni
    J Dermatol Sci 36:57-9. 2004
  86. pmc Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells
    Vinod Suresh
    Department of Biomedical Engineering, 3120 Natural Sciences II, University of California Irvine, Irvine, CA 92697 2715, USA
    Am J Respir Cell Mol Biol 37:97-104. 2007
    ..NO release from airway epithelial cells can be directly measured. The rate of release in response to IL-13 is strongly dependent on the individual donor, but is primarily due to the expression of iNOS...
  87. ncbi Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function
    Yuling Wang
    Department of Integrative Biology and Pharmacology, The University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:25196-203. 2004
    ..These findings suggest that Stat6 has mechanisms of regulation distinct from other Stats...
  88. ncbi Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11
    S E Wenderfer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Genomics 63:354-73. 2000
    Five related cytokine genes, interleukin 3 (Il3), interleukin 4 (Il4), interleukin 5 (Il5), interleukin 13 (Il13), and granulocyte-macrophage colony-stimulating factor (Csfgm or Csf2), are tightly linked on mouse chromosome 11...
  89. ncbi Functional dissection identifies a conserved noncoding sequence-1 core that mediates IL13 and IL4 transcriptional enhancement
    Jannine M Strempel
    Functional Genomics Laboratory, Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 282:3738-46. 2007
    ....
  90. pmc Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen
    W Debinski
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    Mol Med 6:440-9. 2000
    ..Two IL13 receptor (R) proteins were identified: (1) IL13R alpha', a component of the signaling, heterodimeric high-affinity receptor for IL13 that is shared with IL4, and (2) IL13R alpha, a monomeric, IL4-independent receptor...
  91. ncbi Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 23:89-99. 2005
    ..Based on these probabilities, individual cells randomly express Il4 and Il13 alleles...
  92. ncbi The cattle interleukin-13 gene: genomic organization, chromosomal location, and evolution of the promoter
    J Buitkamp
    Department of Animal Breeding, Technical University Munich, Alte Akademie 12, D 85350 Freising Weihenstephan, Germany
    Immunogenetics 49:872-8. 1999
    ..There is evidence that IL-13, but not IL-14, is the key mediator in allergic asthma. Furthermore IL-13 is involved in resistance to some infections. Therefore IL-13 is of interest for disease association studies in domestic animals...
  93. pmc Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development
    Aurelie Baguet
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 101:11410-5. 2004
    ..Our findings are consistent with a progressive regulatory element activation/deactivation model of TH1/TH2 development...
  94. pmc Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A
    Rogério S Rosada
    Núcleo de Pesquisa em Tuberculose, Departamento de Bioquimica e Imunologia, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 5:e8721. 2010
    ..The aim of the present study was to determine whether the presence of an immune response to P. aeruginosa and/or its exotoxin A (PE) would diminish the anti-fibrotic properties of IL13-PE...
  95. ncbi Clinical studies with targeted toxins in malignant glioma
    Nikolai G Rainov
    The University of Liverpool, Dept Neurological Science, The Walton Centre for Neurology and Neurosurgery NHS Trust, Clinical Sciences Centre for Research and Education, Lower Lane, Liverpool L9 7LJ, UK
    Rev Recent Clin Trials 1:119-31. 2006
    ..It offers in addition an outlook into future areas of development of targeted toxins, such as improved delivery modes and non-invasive in vivo imaging of intracerebral and intratumoral distribution of toxin in patients...
  96. pmc Interleukin 13 in synovial fluid and serum of patients with psoriatic arthritis
    A Spadaro
    Department of Medical Therapy, Rheumatology Unit, University of Rome La Sapienza, Italy
    Ann Rheum Dis 61:174-6. 2002
    ....
  97. doi Gene expression in nasal lavage from hairdressers exposed to persulphate
    Lena S Jönsson
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University Hospital, Lund, Sweden
    Int Arch Occup Environ Health 82:1261-6. 2009
    ..In this study, we analysed gene expression of cytokines in the nose in order to further investigate the mechanism for work-related bleaching powder-associated nasal symptoms...
  98. ncbi Intratumoral therapy with IL13-PE38 results in effective CTL-mediated suppression of IL-13Ralpha2-expressing contralateral tumors
    Koji Kawakami
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville Pike, Rockville, Maryland, USA
    Clin Cancer Res 12:4678-86. 2006
    IL13-PE38, a targeted cytotoxin comprised of interleukin 13 (IL-13) and a mutated form of Pseudomonas exotoxin, induces specific killing of tumor cells expressing abundant levels of the IL-13Ralpha2 chain...
  99. ncbi Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma
    Shahriar Shahzeidi
    Research Center for Genetic Medicine, Children s National Medical Center Department of Pediatrics, George Washington University, Washington, DC 20010, USA
    Exp Lung Res 29:549-65. 2003
    ..Overall, these data demonstrated that a single airway exposure to ovalbumin or IL13 is sufficient to generate goblet cell metaplasia and thus increase mucin gene expression in two strains of mice...
  100. ncbi Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies
    S Kunwar
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Acta Neurochir Suppl 88:105-11. 2003
    ..The preclinical data and details and preliminary results of the three clinical trials are reviewed...
  101. ncbi IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells
    Ulla Angela Temann
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int Immunol 19:1-10. 2007
    ..Our results implicate the lung epithelium as a potentially important source of inflammatory cytokines in asthma...

Research Grants69

  1. IL8 and GATA3-mediated Pathways in Asthma Exacerbations
    Fernando Martinez; Fiscal Year: 2007
    ..End of Abstract) ..
  2. Gutless Adenovirus Mediated Targeted Therapeutics for Glioma
    Marianela Candolfi; Fiscal Year: 2007
    ..Thus, we hypothesize that the targeted glioma gene therapy approach proposed will elicit high therapeutic efficacy in the absence of adverse side effects. ..
  3. Biomarkers of survival in glioma epidemiology
    John Wiencke; Fiscal Year: 2009
    ....
  4. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2007
    ....
  5. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2009
    ..abstract_text> ..
  6. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2011
    ..Our studies will be the first to explore human Th2 cytokine regulation in vivo and will identify novel rational targets for effective treatments of allergic disease. ..
  7. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2011
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  8. Regulated Accessibility of a cytokine gene locus.
    Anjana Rao; Fiscal Year: 2010
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  9. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..We hypothesize that this signaling pathway regulates epithelial, proliferative repair responses after renal injury. If correct, then this would impact on most forms of acute and chronic renal damage. ..
  10. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2010
    ..Based on our results in MDCK cells and zebrafish, we anticipate that these animals will develop renal cystic disease and will mimic human ADPKD most closely mechanistically. ..
  11. IL-13 Fusion Cytotoxin as a Targeted Therapeutic for IIP
    Cory Hogaboam; Fiscal Year: 2006
    ..The proposed studies will critically evaluate a pathophysiologic paradigm in IIP that has not been thoroughly examined to date. ..
  12. Targeted Toxin for Brain Cancer Gene Therapy
    Maria Castro; Fiscal Year: 2007
    ..In summary, we expect to develop a targeted glioma gene therapy approach with high therapeutic efficacy and negligible toxicity which could be translated into clinical trials. ..
  13. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian Hines; Fiscal Year: 2007
    ..Together, these studies will provide new insight into the mechanisms of T cell-mediated hepatic fibrosis. ..
  14. Characterization of Asthma Associated Polymorphisms
    Beverly H Koller; Fiscal Year: 2010
    ..However, there is no in vivo experimental data confirming the importance of these loci in the pathophysiology of asthma. This application plans to evaluate asthma candidate genes in the mouse, using genetic approaches. ..
  15. Molecular studies on the role of IL4 & IL13 in fibrosis
    Constantin Bona; Fiscal Year: 2007
    ..The effect of dominant-positive and dominant-negative constructs on collagen gene expression will be studied in the presence or absence of profibrogenic cytokines. ..
  16. ENVIRONMENT AND EPIGENETIC CONTROL OF IMMUNE RESPONSES
    Mark Bix; Fiscal Year: 2004
    ..identical, suggesting functional links between them and to the developmentally programmed specification of IL4 and IL 13 transcription inducibility...
  17. Molecular Phenotyping of Asthma
    Prescott Woodruff; Fiscal Year: 2009
    ..The ultimate goal of these cell culture studies is to identify new therapies for asthma. (End of Abstract) ..
  18. Molecular Phenotyping of Asthma
    Prescott G Woodruff; Fiscal Year: 2010
    ..The ultimate goal of these cell culture studies is to identify new therapies for asthma. (End of Abstract) ..
  19. Molecular Requirements for Recombinant Cytotoxins Efficacy
    Waldemar Debinski; Fiscal Year: 2007
    A restricted receptor (R) for interleukin 13 (IL13) was found in a vast majority of high-grade gliomas (HGG) patients...
  20. Molecular Requirements for Recombinant Cytotoxins Efficacy
    Waldemar Debinski; Fiscal Year: 2009
    A restricted receptor (R) for interleukin 13 (IL13) was found in a vast majority of high-grade gliomas (HGG) patients...
  21. Molecular Requirements for Recombinant Cytotoxins Efficacy
    Waldemar Debinski; Fiscal Year: 2010
    A restricted receptor (R) for interleukin 13 (IL13) was found in a vast majority of high-grade gliomas (HGG) patients...
  22. High Grade Astrocytoma Specific Molecular Targeting
    Waldemar Debinski; Fiscal Year: 2004
    A restrictive receptor (R) for interleukin 13 (IL13) was found in a vast majority of human high-grade (grade Ill and IV) astrocytoma (HGA) specimens in situ, but not in low-grade (grade I and II) astrocytomas or brain tumors of non-glial ..
  23. IL13-responsive genes in goblet cell metaplasia in asthma
    Mary Rose; Fiscal Year: 2007
    ..This will contribute to the development of pharmacological agents to control GCH and mucus overproduction in patients with asthma and possibly other chronic airway diseases ..
  24. High-Grade Astrocytoma-specific Molecular Targeting
    Waldemar Debinski; Fiscal Year: 2009
    A restricted receptor (R) for interleukin 13 (IL13), IL13Ralpha2, is over-expressed in high-grade (grade III and IV) astrocytoma (HGA) patients. IL13Ralpha2 exhibits characteristics of a cancer/testis tumor like-antigen...
  25. MONOKINE GENE EXPRESSION/REGULATION IN LUNG INJURY
    Steven Kunkel; Fiscal Year: 2007
    ..Our long term goals are to demonstrate the mechanistic contributions of cytokines, TLR, and dendritic cells to the long term problems of severe sepsis and acute lung injury. ..
  26. Regulatory T cells in B cell lymphoma
    HYAM ISAAC LEVITSKY; Fiscal Year: 2010
    ..However one class of cells (so-called regulatory T cells) can inhibit this. Understanding how these cells work will enable strategies to bypass this suppression. ..
  27. Biomarkers of survival in glioma epidemiology
    John K Wiencke; Fiscal Year: 2010
    ....