IKZF3

Summary

Gene Symbol: IKZF3
Description: IKAROS family zinc finger 3
Alias: AIO, AIOLOS, ZNFN1A3, zinc finger protein Aiolos, zinc finger DNA binding protein Aiolos, zinc finger protein, subfamily 1A, 3 (Aiolos)
Species: human
Products:     IKZF3

Top Publications

  1. Caballero R, Setien F, Lopez Serra L, Boix Chornet M, Fraga M, Ropero S, et al. Combinatorial effects of splice variants modulate function of Aiolos. J Cell Sci. 2007;120:2619-30 pubmed
    The transcription factor Aiolos (also known as IKZF3), a member of the Ikaros family of zinc-finger proteins, plays an important role in the control of B lymphocyte differentiation and proliferation...
  2. Wang J, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, et al. Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998;9:543-53 pubmed
    b>Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros...
  3. Schmitt C, Tonnelle C, Dalloul A, Chabannon C, Debre P, Rebollo A. Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation. Apoptosis. 2002;7:277-84 pubmed
    b>Aiolos and Ikaros encode hemopoietic-specific zinc finger transcription factors that are important regulators of lymphocyte differentiation. Aiolos and Ikaros play a critical role in regulating B and T cell development...
  4. Lessard C, Adrianto I, Ice J, Wiley G, Kelly J, Glenn S, et al. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet. 2012;90:648-60 pubmed publisher
    ..62 × 10(-9)), and 17q21 (rs1453560; p(meta-all) = 3.48 × 10(-10)) between IKAROS family of zinc finger 3 (AIOLOS; IKZF3) and zona pellucida binding protein 2 (ZPBP2)...
  5. Marinho S, Custovic A, Marsden P, Smith J, Simpson A. 17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. Ann Allergy Asthma Immunol. 2012;108:402-411.e9 pubmed publisher
    ..We conducted a comprehensive investigation of 28 common SNPs within 6 genes of interest (IKZF3, ZPBP2, ORMDL3, GSDMA, GSDMB, TOP2A)...
  6. Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997;16:2004-13 pubmed
    ..Here we report the cloning of Aiolos, a gene which encodes an Ikaros homologue that heterodimerizes with Ikaros proteins...
  7. Sun J, Matthias G, Mihatsch M, Georgopoulos K, Matthias P. Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice. J Immunol. 2003;170:1699-706 pubmed
    Here we show that mice lacking the zinc finger transcription factor Aiolos develop the symptoms of human systemic lupus erythematosus (SLE), which is characterized by the production of anti-dsDNA Ab and immune complex-mediated ..
  8. Billot K, Parizot C, Arrouss I, Mazier D, Debre P, Rogner U, et al. Differential aiolos expression in human hematopoietic subpopulations. Leuk Res. 2010;34:289-93 pubmed publisher
    The Aiolos transcription factor plays a crucial role in the control of lymphocyte differentiation and proliferation...
  9. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999;10:345-55 pubmed
    ..Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases, in a 2 MD complex...

More Information

Publications117 found, 100 shown here

  1. Gandhi R, Kumar D, Burns E, Nadeau M, Dake B, Laroni A, et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010;11:846-53 pubmed publisher
    ..of functional Foxp3(+) iT(reg) cells required coordinated action of the transcriptional regulators Smad1 and Aiolos. Thus, AhR is a potential target through which functional iT(reg) cells could be induced in human autoimmune ..
  2. van Hamburg J, Tas S. Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis. J Autoimmun. 2018;87:69-81 pubmed publisher
    ..by established genetic risk factors for RA including CCR6, CD226, CSF2, EOMES, ETS1, GATA3, IL2, IL6R, IL23R, IKZF3, IRAK1, IRF4, IRF8, PRKCQ, PRDM1, RBPJ, RUNX1 and TAGAP are directly involved in Th17 cell differentiation and/or ..
  3. Hannah J, Zhou P. Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B. Gene. 2015;573:33-45 pubmed publisher
    ..binding to the CRL4CRBN complex and re-directing the E3 ligase towards the Ikaros transcription factors IKZF1 and IKZF3. Because of their influence over key cellular functions and relevance to human disease, CRL4s are considered ..
  4. Lindner S, Krönke J. The molecular mechanism of thalidomide analogs in hematologic malignancies. J Mol Med (Berl). 2016;94:1327-1334 pubmed
    ..Binding of thalidomide or lenalidomide increases the affinity of CRBN to the transcription factors IKZF1 and IKZF3 and casein kinase 1α (CK1α)...
  5. Bystrom J, Taher T, Muhyaddin M, Clanchy F, Mangat P, Jawad A, et al. Harnessing the Therapeutic Potential of Th17 Cells. Mediators Inflamm. 2015;2015:205156 pubmed publisher
    ..development, Th17 cells require activation of the transcription factors STAT3 and RORγt while RUNX1, c-Maf, and Aiolos are involved in changes of phenotype/functions...
  6. Gopalakrishnan R, Matta H, Tolani B, Triche T, Chaudhary P. Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2016;35:1797-810 pubmed publisher
    ..anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 and rapid degradation of IKZF1, but not IKZF3. Small hairpin RNA-mediated knockdown of MYC enhanced the cytotoxicity of IMiDs...
  7. Cai Q, Li J. [Association of CRBN Gene with Immunomodulatory Drug Resis- tance in Multiple Myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:892-7 pubmed publisher
    ..Furthermore, the most recently discovered protein IKZF1, IKZF3, IRF4, C/EBPβ and Wnt/catenin signaling pathways may also be closely related to IMiD resistance in myeloma.
  8. Ghanbari M, Franco O, de Looper H, Hofman A, Erkeland S, Dehghan A. Genetic Variations in MicroRNA-Binding Sites Affect MicroRNA-Mediated Regulation of Several Genes Associated With Cardio-metabolic Phenotypes. Circ Cardiovasc Genet. 2015;8:473-86 pubmed publisher
    ..Conversely, 2 variants, rs6857 (PVRL2:miR-320e) and rs907091 (IKZF3:miR-326), were shown to enhance the activity of miRNAs on their host genes...
  9. Bouffi C, Kartashov A, Schollaert K, Chen X, Bacon W, Weirauch M, et al. Transcription Factor Repertoire of Homeostatic Eosinophilopoiesis. J Immunol. 2015;195:2683-95 pubmed publisher
    ..EoPs and Eos, but not granulocyte-monocyte progenitors or neutrophils, expressed Helios and Aiolos, members of the Ikaros family of transcription factors, which regulate gene expression via modulation of chromatin ..
  10. Casas Flores S, Gómez Rodríguez E, García Meza J. Community of thermoacidophilic and arsenic resistant microorganisms isolated from a deep profile of mine heaps. AMB Express. 2015;5:132 pubmed publisher
    ..in the microbial community, therefore specific primers were used to amplify ars (arsenic resistance system), aio (arsenite oxidase), or arr (arsenate respiratory reduction) genes from total sample DNA...
  11. Nandre V, Bachate S, Salunkhe R, Bagade A, Shouche Y, Kodam K. Enhanced Detoxification of Arsenic Under Carbon Starvation: A New Insight into Microbial Arsenic Physiology. Curr Microbiol. 2017;74:614-622 pubmed publisher
    ..Enhanced arsenic-oxidizing ability of the strains was validated by the presence of aio gene and RT-PCR, where 0.5- to 26-fold up-regulation of arsenite oxidase gene in different genera was observed...
  12. Xiao K, Li L, Ma L, Zhang S, Bao P, Zhang T, et al. Metagenomic analysis revealed highly diverse microbial arsenic metabolism genes in paddy soils with low-arsenic contents. Environ Pollut. 2016;211:1-8 pubmed publisher
    ..in all soil samples, and significant correlation existed between the abundance of arr (arsenate respiration), aio (arsenite oxidation), and arsM (arsenite methylation) genes, indicating the co-existence and close-relation of ..
  13. Koechler S, Arsène Ploetze F, Brochier Armanet C, Goulhen Chollet F, Heinrich Salmeron A, Jost B, et al. Constitutive arsenite oxidase expression detected in arsenic-hypertolerant Pseudomonas xanthomarina S11. Res Microbiol. 2015;166:205-14 pubmed publisher
    ..One of them is located on a plasmid and is organized as an "arsenic island" harbouring an aio operon and genes involved in phosphorous metabolism, in addition to the ars genes...
  14. Zhang H, Zhang N, Wang R, Shao T, Feng Y, Yao Y, et al. High expression of miR-363 predicts poor prognosis and guides treatment selection in acute myeloid leukemia. J Transl Med. 2019;17:106 pubmed publisher
    ..was positively correlated with the amounts of leukemogenic transcription factors, including Myb, RUNX3, GATA3, IKZF3, ETS1 and MLLT3...
  15. Netter J, Douard R, Durdux C, Landi B, Berger A, Taieb J. Advances in management of adjuvant chemotherapy in rectal cancer: Consequences for clinical practice. Clin Res Hepatol Gastroenterol. 2016;40:546-552 pubmed publisher
    ..Two of them (ADORE, CAO/ARO/AIO-04) appeared to find a disease-free survival benefit for patients treated with the combination therapy...
  16. Ruiz Larrañaga O, Uribarri M, Alcaro M, Escorza Treviño S, del Amo J, Iriondo M, et al. Genetic variants associated with rheumatoid arthritis patients and serotypes in European populations. Clin Exp Rheumatol. 2016;34:236-41 pubmed
    ..and CCR6 have been confirmed as RA disease associated loci together with recently discovered BACH2, RASGRP1, and IKZF3 loci, taking all RA patients as a unique phenotype...
  17. Wiemels J, Walsh K, de Smith A, Metayer C, Gonseth S, Hansen H, et al. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun. 2018;9:286 pubmed publisher
    ..Here we identify new risk loci on 17q12 near IKZF3/ZPBP2/GSDMB/ORMDL3, a locus encompassing a transcription factor important for lymphocyte development (IKZF3), and ..
  18. Rasco D, Papadopoulos K, Pourdehnad M, Gandhi A, Hagner P, Li Y, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019;25:90-98 pubmed publisher
    ..A dose-dependent relationship between Aiolos degradation in peripheral B and T cells occurred within 5 hours of the first dose of avadomide administered, ..
  19. Liu S, Gao F. [Role and Significance of Ikaros Family in the Development of Hematopoietic System -Review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1227-1231 pubmed publisher
    ..structure of the Ikaros family, which belong to the zinc finger transcription factor, including Ikaros, Helios, Aiolos, Eos and Pegasus, are encoded by IKZF1-5 genes, respectively...
  20. Sawle A, Kebschull M, Demmer R, Papapanou P. Identification of Master Regulator Genes in Human Periodontitis. J Dent Res. 2016;95:1010-7 pubmed publisher
    ..analysis showed significant enrichment of 36 regulons for several pathways, while 6 regulons (those of MRs HCLS1, IKZF3, ETS1, NHLH2, POU2F2, and VAV1) were enriched for >10 pathways...
  21. Wang Q, Warelow T, Kang Y, Romano C, Osborne T, Lehr C, et al. Arsenite oxidase also functions as an antimonite oxidase. Appl Environ Microbiol. 2015;81:1959-65 pubmed publisher
    ..ArsR, they differ in the regulatory mechanisms that control the expression of genes encoding the different Ars or Aio activities...
  22. Gao S, Geng C, Song T, Lin X, Liu J, Cai Z, et al. Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase. J Biol Chem. 2017;292:3683-3691 pubmed publisher
    ..or genetic ablation of the Abl-DDB1-DDA1 axis decreases the ubiquitination of CRL4 substrates, including IKZF1 and IKZF3, in lenalidomide-treated multiple myeloma cells...
  23. Zhu Z, Wang H, Wei Y, Meng F, Liu Z, Zhang Z. Downregulation of PRDM1 promotes cellular invasion and lung cancer metastasis. Tumour Biol. 2017;39:1010428317695929 pubmed publisher
    ..PRDM1 is silenced by an ectopically expressed lymphocyte-specific transcription factor Aiolos. The transcription of these two genes is negatively correlated in 206 lung epithelial cell lines...
  24. Söderman J, Berglind L, Almer S. Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility. Biomed Res Int. 2015;2015:834805 pubmed publisher
    ..0 × 10(-4)-1.0 × 10(-9)) and the increased colonic expression of IKZF3 and CSF3 (P = 2.4 × 10(-7)-3.5 × 10(-8))...
  25. Swafford A, Howson J, Davison L, Wallace C, Smyth D, Schuilenburg H, et al. An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes. 2011;60:1041-4 pubmed publisher
    ..Further investigation is warranted for the genetic effect marked by rs10272724, its impact on IKZF1, and the role of Ikaros and other family members, Ailios (IKZF3) and Eos (IKZF4), in autoimmunity.
  26. Kang Y, Bi W, Dubuc A, Martineau L, Ligon A, Berkowitz A, et al. Integrated Genomic Characterization of a Pineal Parenchymal Tumor of Intermediate Differentiation. World Neurosurg. 2016;85:96-105 pubmed publisher
    ..Targeted exome sequencing showed mutations in TSC1(L388P) and IKZF3(F206C), whereas high-resolution array cytogenetics revealed losses in chromosomes 2, 3, 4, 8, 10, 11, 17, and 20, ..
  27. Burón E, Bulbena A, Bulbena Cabré A, Rosado S, Pailhez G. Both anxiety and joint laxity determine the olfactory features in panic disorder. Psychiatry Res. 2018;262:420-426 pubmed publisher
    ..performed the Sniffin' Sticks Test (SST) (threshold subtest), and completed the Affective Impact of Odors scale (AIO), the Relational Scale of Olfaction (EROL), and the Odor Awareness Scale (OAS)...
  28. Mirji G, Bhat J, Kode J, Banavali S, Sengar M, Khadke P, et al. Risk stratification of T-cell Acute Lymphoblastic Leukemia patients based on gene expression, mutations and copy number variation. Leuk Res. 2016;45:33-9 pubmed publisher
    ..TCRγδ+T-ALL patients exhibited differential level of mutations for NOTCH1 and IKZF3; however BRAF mutations were detected at equal levels in both the subgroups...
  29. Granell R, Henderson A, Timpson N, St Pourcain B, Kemp J, Ring S, et al. Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes. J Allergy Clin Immunol. 2013;131:685-94 pubmed publisher
    ..4 × 10(-11); rs2305480 near GSDML: RRR, 1.60 [95% CI, 1.39-1.83], P = 1.5 × 10(-11); and rs9303277 near IKZF3: RRR, 1.57 [95% CI, 1.37-1.79], P = 4.4 × 10(-11))...
  30. Stintzing S, Miller Phillips L, Modest D, Fischer von Weikersthal L, Decker T, Kiani A, et al. Impact of BRAF and RAS mutations on first-line efficacy of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab: analysis of the FIRE-3 (AIO KRK-0306) study. Eur J Cancer. 2017;79:50-60 pubmed publisher
    ..ETS represents an early parameter associated with the benefit from anti-EGFR, while this was not the case with vascular endothelial growth factor A blockade. ..
  31. Smith M, Rihanek M, Wasserfall C, Mathews C, Atkinson M, Gottlieb P, et al. Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles. Diabetes. 2018;67:697-703 pubmed publisher
    ..e., PTPN2 [rs1893217], INS [rs689], and IKZF3 [rs2872507]), relevant to B- and T-cell development and function are associated with loss of anergy...
  32. Duval S, Santini J, Lemaire D, Chaspoul F, Russell M, Grimaldi S, et al. The H-bond network surrounding the pyranopterins modulates redox cooperativity in the molybdenum-bisPGD cofactor in arsenite oxidase. Biochim Biophys Acta. 2016;1857:1353-1362 pubmed publisher
    ..results indicated the possibility of cooperative (n=2) redox behavior in the bioenergetic enzyme arsenite oxidase (Aio)...
  33. Chen J, Zhang J, Hu H, Xue M, Jin Y. Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population. Allergol Immunopathol (Madr). 2017;45:432-438 pubmed publisher
    To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children...
  34. Cai X, Huang W, Liu X, Wang L, Jiang Y. Association of novel polymorphisms in TMEM39A gene with systemic lupus erythematosus in a Chinese Han population. BMC Med Genet. 2017;18:43 pubmed publisher
    ..aimed to assess the association between 14 single nucleotide polymorphisms (SNPs) in six genes (IRF8, TMEM39A, IKZF3, ORMDL3, GSDMB, and ZPBP2) and systemic lupus erythematosus (SLE) in a Chinese Han population sample...
  35. Stahl M, Maderer A, Lordick F, Mihaljevic A, Kanzler S, Hoehler T, et al. Perioperative chemotherapy with or without epidermal growth factor receptor blockade in unselected patients with locally advanced oesophagogastric adenocarcinoma: Randomized phase II study with advanced biomarker program of the German Cancer Society . Eur J Cancer. 2018;93:119-126 pubmed publisher
    ..Low plasma levels of pathway-associated proteins such as sEGFR may identify a group of patients that benefit from EGFR-directed therapy. CLINICALTRIALS.GOV: NCT01234324. ..
  36. Liu Y, He X, Sui Y, Yu R, Xu G. Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition. FEBS Lett. 2015;589:2233-40 pubmed publisher
    ..One mechanism involves the ubiquitination and degradation of two transcription factors, IKZF1 and IKZF3. Whether there are other degradation pathways for IKZF1 in myeloma cells remains unknown...
  37. Safavi S, Olsson L, Biloglav A, Veerla S, Blendberg M, Tayebwa J, et al. Genetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia. Oncotarget. 2015;6:42793-802 pubmed publisher
    ..In line with previous studies, mutations in IKZF3 and FLT3 were detected in near-haploid (25-30 chromosomes) cases...
  38. Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, et al. Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells. Biochem Biophys Res Commun. 2016;469:236-42 pubmed publisher
    ..binds to damaged DNA-binding protein and functions as a ubiquitin ligase, inducing degradation of IKZF1 and IKZF3 that are essential transcription factors for B and T cell development...
  39. Nguyen T, Li J, Lu C, Mamrosh J, Lu G, Cathers B, et al. p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017;114:3565-3571 pubmed publisher
    ..for the degradation of all four known CRBN neo-substrates [Ikaros family zinc finger proteins 1 (IKZF1) and 3 (IKZF3), casein kinase 1α (CK1α), and the translation termination factor GSPT1] whose ubiquitylation is induced by ..
  40. Wein A, Siebler J, Wolff K, Ostermeier N, Busse D, Hagel A, et al. Weekly High-dose 5-Fluorouracil as 24-hour Infusion Combined with Sodium Folinic Acid (AIO regimen) Plus Irinotecan in Second-line and Sequential Therapy of Metastatic Colorectal Cancer (CRC). Anticancer Res. 2017;37:3771-3779 pubmed
    ..combined with sodium folinic acid (FA) (AIO-regimen) plus irinotecan (Iri.) after pretreatment with AIO-regimen plus oxaliplatin (L-OHP)...
  41. Heizmann B, Kastner P, Chan S. The Ikaros family in lymphocyte development. Curr Opin Immunol. 2018;51:14-23 pubmed publisher
    The IKZF family of transcription factors are essential regulators of lymphopoiesis. Ikaros, Helios, Aiolos and Eos function as transcriptional repressors and activators during T and B cell differentiation and in mature cell function, ..
  42. Michl M, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling Kaiser U, et al. CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial). Ann Oncol. 2016;27:1565-72 pubmed publisher
    ..NCT00433927 (ClinicalTrials.gov); AIO KRK0306 FIRE-3.
  43. Mareschal S, Pham Ledard A, Viailly P, Dubois S, Bertrand P, Maingonnat C, et al. Identification of Somatic Mutations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type by Massive Parallel Sequencing. J Invest Dermatol. 2017;137:1984-1994 pubmed publisher
    ..led us to perform resequencing of three selected genes not included in the lymphoma panel: TBL1XR1, KLHL6, and IKZF3. Our study clearly identifies an original mutational landscape of PCLBCL-LT with a very restricted set of highly ..
  44. Zhang S, Song Z. Aio-Casilio: a robust CRISPR-Cas9-Pumilio system for chromosome labeling. J Mol Histol. 2017;48:293-299 pubmed publisher
    ..We reported the development of 'all-in-one Casilio system (Aio-Casilio)', a new system that enables the labeling of endogenous genomic loci...
  45. Patil A, Manzano M, Gottwein E. CK1? and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma. Blood. 2018;132:577-586 pubmed publisher
    ..ubiquitin ligase complex, leading to the acquisition of the Ikaros family zinc finger proteins 1 and 3 (IKZF1 and IKZF3), casein kinase 1 ? (CK1?), and zinc finger protein 91 (ZFP91) as neosubstrates...
  46. Hartmann J, Issels R, Nicolo K, Grünwald V, Hertenstein B, Papesch E, et al. Topotecan plus cyclophosphamide in adults with relapsed or refractory pediatric-type sarcoma: a retrospective analysis from the German Sarcoma Medical Oncology Group (AIO). Invest New Drugs. 2015;33:1115-22 pubmed publisher
    ..PD), adequate organ functions, who have been treated with TC combination were retrospectively analysed within the AIO and SAREZ/BMBF network...
  47. Eriksson M, Reichardt P, Sundby Hall K, Schütte J, Cameron S, Hohenberger P, et al. Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?. Eur J Cancer. 2016;59:128-133 pubmed publisher
    ..who participated in the Scandinavian Sarcoma Group (SSG) XVIII/Arbeitsgemeinschaft Internistische Onkologie (AIO) randomised trial and who had a transabdominal fine needle and/or core needle biopsy carried out prior to study ..
  48. Matyskiela M, Zhang W, Man H, Muller G, Khambatta G, Baculi F, et al. A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. J Med Chem. 2018;61:535-542 pubmed publisher
    ..bind to the protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to cause their ubiquitination and degradation...
  49. Al Batran S, Homann N, Pauligk C, Illerhaus G, Martens U, Stoehlmacher J, et al. Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial. JAMA Oncol. 2017;3:1237-1244 pubmed publisher
    ..The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, leucovorin, oxaliplatin, and docetaxel) trial is ..
  50. Holch J, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, et al. Relevance of liver-limited disease in metastatic colorectal cancer: Subgroup findings of the FIRE-3/AIO KRK0306 trial. Int J Cancer. 2017;: pubmed publisher
    ..LLD had no predictive relevance since benefit from FOLFIRI plus cetuximab over bevacizumab was independent of LLD status...
  51. Hagner P, Man H, Fontanillo C, Wang M, Couto S, Breider M, et al. CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL. Blood. 2015;126:779-89 pubmed publisher
    ..drugs to CRBN promotes the ubiquitination and subsequent degradation of 2 common substrates, transcription factors Aiolos and Ikaros...
  52. Croner R, Sevim M, Metodiev M, Jo P, Ghadimi M, Schellerer V, et al. Identification of Predictive Markers for Response to Neoadjuvant Chemoradiation in Rectal Carcinomas by Proteomic Isotope Coded Protein Label (ICPL) Analysis. Int J Mol Sci. 2016;17:209 pubmed publisher
    ..standardized nCRT with 5-Fluoruracil (nCRT I) or 5-Fluoruracil ± Oxaliplatin (nCRT II) according to the CAO/ARO/AIO-04 protocol...
  53. Schmitt T, Mayer Steinacker R, Mayer F, Grünwald V, Schütte J, Hartmann J, et al. Vorinostat in refractory soft tissue sarcomas - Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO). Eur J Cancer. 2016;64:74-82 pubmed publisher
    ..Further studies aiming to identify predictive markers for treatment response as well as exploration of combination regimens are warranted. NCT00918489 (ClinicalTrials.gov) EudraCT-number: 2008-008513-19. ..
  54. Mitchell J, Seng A, Yankee T. Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes. Immunology. 2016;149:400-412 pubmed publisher
    ..Our goal is to determine how protein levels of Ikaros, Helios and Aiolos change as human thymocytes progress through the positive selection and lineage commitment stages...
  55. Krönke J, Kuchenbauer F, Kull M, Teleanu V, Bullinger L, Bunjes D, et al. IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM). Leukemia. 2017;31:1363-1367 pubmed publisher
    ..ligase results in targeted ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) leading to growth inhibition of multiple myeloma cells...
  56. von Laffert M, Schirmacher P, Warth A, Weichert W, Buttner R, Huber R, et al. ALK-Testing in non-small cell lung cancer (NSCLC): Immunohistochemistry (IHC) and/or fluorescence in-situ Hybridisation (FISH)?: Statement of the Germany Society for Pathology (DGP) and the Working Group Thoracic Oncology (AIO) of the German Cancer S. Lung Cancer. 2017;103:1-5 pubmed publisher
    ..This consensus paper provides recommendations for the test algorithm and quality of the respective test approaches, which are discussed in the light of the current literature. ..
  57. Modest D, Ricard I, Heinemann V, Hegewisch Becker S, Schmiegel W, Porschen R, et al. Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants: pooled analysis of five randomized trials in metastatic colorectal cancer by the AIO colorectal cancer study group. Ann Oncol. 2016;27:1746-53 pubmed publisher
    ..KRAS exon 2 mutation variants were associated with heterogeneous outcome compared with unmutated tumors with KRAS G12C and G13D (trend) being associated with rather poor survival. ..
  58. Hofmann F, Holch J, Heinemann V, Ricard I, Reiser M, Baumann A, et al. Prognostic value of radiologically enlarged lymph nodes in patients with metastatic colorectal cancer: Subgroup findings of the randomized, open-label FIRE-3/AIO KRK0306 trial. Eur J Radiol. 2018;100:124-129 pubmed publisher
    ..The prospective, randomized, open-label FIRE-3/AIO KRK0306 trial evaluated the first-line therapy of patients with KRAS exon 2 wild-type metastatic colorectal cancer ..
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    ..Here we find that a lymphocyte lineage-restricted transcription factor, Aiolos, is frequently expressed in lung cancers and predicts markedly reduced patient survival...
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    To characterize the regulation of lymphoid Aiolos transcription factor, we have cloned its promoter. Full promoter and nested deletions were expressed in lymphoid and non-lymphoid cell lines...
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    The Aiolos transcription factor, member of the Ikaros family of zinc finger proteins, plays an important role in the control of mature B lymphocyte differentiation and proliferation, and its function appears to be modulated through ..
  63. Fang M, Becker P, Linenberger M, Eaton K, Appelbaum F, Dreyer Z, et al. Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients. Am J Clin Pathol. 2015;144:263-70 pubmed publisher
    ..of adult B-ALL with masked low hypodiploidy (mLH) by genomic duplication, along with a somatic deletion of the IKZF3 gene and a somatic TP53 mutation...
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    ..Here we identified Aiolos, an anti-apoptotic transcription factor of MM cells, as a Blimp-1-interacting protein by mass spectrometry...
  65. Solingapuram Sai K, Donald Gage H, Almaguel F, Neth B, Hughes T, Tremblay S, et al. Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module. Appl Radiat Isot. 2017;129:57-61 pubmed publisher
    ..The total synthesis required ~ 16min. PET imaging studies were conducted with 1-[11C]acetoacetate in vervet monkeys to validate the radiochemical synthesis. Tissue uptake distribution was similar to that reported in humans. ..
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    ..that under T(H)17-polarizing conditions, the transcription factors STAT3 and AhR upregulated the expression of Aiolos, a member of the Ikaros family of transcription factors...
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    ..One previously identified factor, Aiolos, probably serves this role in the lymphoid system; a related factor involved in hematopoietic progenitors remains ..
  68. Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, et al. Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia. Exp Hematol. 2002;30:313-7 pubmed
    ..In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-..
  69. Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, et al. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet. 2012;91:721-8 pubmed publisher
    ..21 non-HLA susceptibility loci for PBC identified in GWASs of individuals of European descent, three loci (IL7R, IKZF3, and CD80) showed significant associations (combined p = 3.66 × 10(-8), 3.66 × 10(-9), and 3...
  70. Galanter J, Gignoux C, Torgerson D, Roth L, Eng C, Oh S, et al. Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. J Allergy Clin Immunol. 2014;134:295-305 pubmed publisher
    ..We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos (IKZF3, lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0...
  71. Zhuang Y, Lu Y, Li D, Sun N, Ju X. Upregulation of AIOLOS induces apoptosis and enhances etoposide chemosensitivity in Jurkat leukemia cells. Oncol Rep. 2015;33:1319-25 pubmed publisher
    ..The AIOLOS gene is necessary to control lymphocyte differentiation and may be a potential target of T-ALL therapy...
  72. Billot K, Soeur J, Chereau F, Arrouss I, Merle Béral H, Huang M, et al. Deregulation of Aiolos expression in chronic lymphocytic leukemia is associated with epigenetic modifications. Blood. 2011;117:1917-27 pubmed publisher
    ..b>Aiolos, a member of the Ikaros family of zinc-finger transcription factors, plays an important role in the control of ..
  73. Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M. Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. Genomics. 1999;61:326-9 pubmed
    ..Recently, an Ikaros-related zinc finger protein, called Aiolos (ZNFN1A3), has been identified and characterized, thus establishing the presence of a gene family whose members may be ..
  74. Nakayama Y, Kosek J, Capone L, Hur E, Schafer P, Ringheim G. Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity. J Immunol. 2017;199:2388-2407 pubmed publisher
    ..B cell differentiation transcription factors in memory, DN, and naive B cells in SLE show elevated levels of Aiolos, whereas Ikaros levels are unchanged...
  75. Goey K, Elias S, Hinke A, van Oijen M, Punt C, Hegewisch Becker S, et al. Clinicopathological factors influencing outcome in metastatic colorectal cancer patients treated with fluoropyrimidine and bevacizumab maintenance treatment vs observation: an individual patient data meta-analysis of two phase 3 trials. Br J Cancer. 2017;: pubmed publisher
    The CAIRO3 and AIO 0207 trials demonstrated the efficacy of fluoropyrimidine plus bevacizumab (FP+Bev) maintenance treatment in metastatic colorectal cancer (mCRC) patients...
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    ..23; P = 2 × 10(-6)). By focusing on the combined phenotype of asthma with hay fever, variants associated with the risk of allergic disease can be identified with greater efficiency. ..
  77. Li L, Wang W, Cui H, Zheng X, Chen Y, Sheng Y, et al. The allele T of rs10852936 confers risk for early-onset psoriasis. J Dermatol Sci. 2015;77:129-31 pubmed publisher
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    ..ERBB2 and containing the PPARBP, CRK7, NEUROD2, PPP1R1B, STARD3, TCAP, PNMT, CAB2, ERBB2, C17ORF37, GRB7 and ZNFN1A3 genes, was associated with breast cancer risk...
  79. Scarlata C, Celse C, Pignon P, Ayyoub M, Valmori D. Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. Eur J Immunol. 2015;45:474-9 pubmed publisher
    ..cells that do not express Helios, a transcription factor that characterizes natural Treg cells, but that express Aiolos, which is involved in the differentiation of TH17 and induced Treg cells...
  80. Miloro M, McKnight M, Han M, Markiewicz M. Discectomy without replacement improves function in patients with internal derangement of the temporomandibular joint. J Craniomaxillofac Surg. 2017;45:1425-1431 pubmed publisher
    ..Postoperatively 15 of 17 patients (88%) improved to AiO or AiI, and the two patients with poor compliance remained at AiII, but with marked pain reduction...
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    ..FoxP3 was inactive when complexed with the histone methyltransferase EZH2 and transcription factors YY1 and IKZF3. The latter complex partitioned to a peripheral region of the nucleus, as shown by super-resolution microscopy...
  82. Rebollo A, Ayllon V, Fleischer A, Martinez C, Zaballos A. The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. J Immunol. 2001;167:6366-73 pubmed
    ..and indirect immunofluorescence techniques, we found that Bcl-xL interacts with the transcription factor Aiolos in IL-4-stimulated cells, increasing upon IL-4 deprivation...
  83. Hirschfield G, Liu X, Xu C, Lu Y, Xie G, Lu Y, et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med. 2009;360:2544-55 pubmed publisher
    ..Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown...
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    ..By means of RT-PCR and specific primers we investigated the expression of Ikaros, Aiolos and Helios transcription factors and their splicing variants in seven leukemia cell lines derived from different ..
  85. Gandhi A, Kang J, Havens C, Conklin T, Ning Y, Wu L, et al. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). Br J Haematol. 2014;164:811-21 pubmed publisher
    ..Here we demonstrate that interaction of the transcription factors Ikaros (IKZF1, encoded by the IKZF1 gene) and Aiolos (IKZF3, encoded by the IKZF3 gene) with CRL4(CRBN) is induced by lenalidomide or pomalidomide...
  86. Wagner T, McLaughlin S, Garg K, Cheung C, Larsen B, Styrchak S, et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science. 2014;345:570-3 pubmed publisher
    ..Over time on ART, a greater proportion of persisting proviruses were in proliferating cells. HIV integration into specific genes may promote proliferation of HIV-infected cells, slowing viral decay during ART...
  87. Eichner R, Heider M, Fernández Sáiz V, van Bebber F, Garz A, Lemeer S, et al. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016;22:735-43 pubmed publisher
    ..These findings provide a common mechanistic framework to explain both the teratogenic and pleiotropic antitumor effects of IMiDs. ..
  88. Al Batran S, Hofheinz R, Pauligk C, Kopp H, Haag G, Luley K, et al. Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT. Lancet Oncol. 2016;17:1697-1708 pubmed publisher
    ..Perioperative FLOT was active and feasible to administer, and might represent an option for patients with locally advanced, resectable gastric or gastro-eosophageal junction adenocarcinoma. None. ..
  89. Pourabdollah M, Bahmanyar M, Atenafu E, Reece D, Hou J, Chang H. High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide. J Hematol Oncol. 2016;9:123 pubmed
    ..4 months. By immunohistochemistry (IHC), IKZF1 and IKZF3 were expressed in 72 and 58% of the cases, respectively...
  90. Modest D, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, et al. Evaluation of survival across several treatment lines in metastatic colorectal cancer: Analysis of the FIRE-3 trial (AIO KRK0306). Eur J Cancer. 2017;84:262-269 pubmed publisher
    ..When OS curves separate, only few patients receive active systemic treatment in short courses, suggesting that earlier treatment effects are responsible for later kinetics of survival curves. ..
  91. Koishibayev Z, Turgunov Y, Sandblom G, Lavrinenko A, Zhumakayev A. [DYNAMICS OF ENTEROPERITONEAL TRANSLOCATION OF MICROORGANISMS ON THE EXPERIMANTAL MODEL OF ACUTE INTESTINAL OBSTRUCTION]. Georgian Med News. 2017;:108-115 pubmed
    ..of the dynamics of enteroperitoneal translocation of bacteria on the model of acute intestinal obstruction (AIO) in rats by performing an experimental study on laboratory animals...
  92. Koipally J, Georgopoulos K. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J Biol Chem. 2000;275:19594-602 pubmed
    ..Ikaros isoforms through a PEDLS motif present at the N terminus of these proteins but not with homologues like Aiolos which lack this motif...