IGH

Summary

Gene Symbol: IGH
Description: immunoglobulin heavy locus
Alias: IGH.1@, IGH@, IGHDY1, immunglobulin heavy chain variable region
Species: human

Top Publications

  1. pmc Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
    Tanawan Kummalue
    Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand
    Diagn Pathol 5:31. 2010
  2. ncbi T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma
    B Streubel
    Department of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Leukemia 19:652-8. 2005
  3. doi MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia
    Elisa Tassano
    Department of Pediatric Hematology Oncology, Giannina Gaslini Institute, Genova, Italy
    Genes Chromosomes Cancer 49:682-7. 2010
  4. ncbi Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes
    J G Flanagan
    Nature 300:709-13. 1982
  5. ncbi Pathology of aging B6;129 mice
    D C Haines
    Veterinary Pathology Section, Pathology Histotechnology Laboratory, SAIC Frederickm, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Pathol 29:653-61. 2001
  6. ncbi Treatment of low grade gastric mucosa-associated lymphoid tissue lymphoma in stage I with Helicobacter pylori eradication. Long-term results after sequential histologic and molecular follow-up
    C Montalban
    Department of Internal Medicine, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain
    Haematologica 86:609-17. 2001
  7. ncbi Fluorescence in situ hybridization detection of chromosome IGH/BCL2 translocations from paraffin-embedded tissue: evaluation in follicular lymphoma
    Yuko Hirose
    Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan
    Int J Hematol 78:154-9. 2003
  8. ncbi [Pathologic diagnosis and subtyping of lymphoma in bone marrow biopsies using histologic examination, immunohistochemistry and gene rearrangement studies]
    Jia Cheng Xiao
    Department of Pathology, Rui Jin Hospital of Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Bing Li Xue Za Zhi 33:120-4. 2004
  9. ncbi Interphase fluorescence in situ hybridization is more sensitive than BIOMED-2 polymerase chain reaction protocol in detecting IGH-BCL2 rearrangement in both fixed and frozen lymph node with follicular lymphoma
    Marc Antoine Belaud-Rotureau
    Pathology Laboratory, CHU Bordeaux, 33604 Pessac, France
    Hum Pathol 38:365-72. 2007
  10. pmc Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription?
    Mara L Lennard
    Marine Biomedicine and Environmental Sciences Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    BMC Mol Biol 8:8. 2007

Detail Information

Publications162 found, 100 shown here

  1. pmc Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis
    Tanawan Kummalue
    Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand
    Diagn Pathol 5:31. 2010
    ..Specific PCR primers sequences for IgH gene variable region 3, including fluorescence labeled IgH primers were used and results were compared with HRM...
  2. ncbi T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma
    B Streubel
    Department of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Leukemia 19:652-8. 2005
    ..1;q32) or trisomy 3. This study identifies FOXP1 as a new translocation partner of IGH in a site-dependent subset of MALT lymphomas.
  3. doi MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia
    Elisa Tassano
    Department of Pediatric Hematology Oncology, Giannina Gaslini Institute, Genova, Italy
    Genes Chromosomes Cancer 49:682-7. 2010
    ..As a rule, IGH translocations generate transcriptional activation of the oncogene localized in the proximity of the breakpoint...
  4. ncbi Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes
    J G Flanagan
    Nature 300:709-13. 1982
    ..This implies an evolutionary duplication in this multigene family involving gamma, epsilon and alpha genes...
  5. ncbi Pathology of aging B6;129 mice
    D C Haines
    Veterinary Pathology Section, Pathology Histotechnology Laboratory, SAIC Frederickm, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Pathol 29:653-61. 2001
    ..Immunohistochemistry revealed CD45R expression as well as infiltration by many CD3+ T cells. IgH gene rearrangements were found in typical mesenteric node lymphomas indicating B-cell origin...
  6. ncbi Treatment of low grade gastric mucosa-associated lymphoid tissue lymphoma in stage I with Helicobacter pylori eradication. Long-term results after sequential histologic and molecular follow-up
    C Montalban
    Department of Internal Medicine, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain
    Haematologica 86:609-17. 2001
    ..Moreover, in half of the apparently cured patients a monoclonal rearrangement of the IgH gene can be demonstrated. However, data on the long-term outcome of the patients are scarce...
  7. ncbi Fluorescence in situ hybridization detection of chromosome IGH/BCL2 translocations from paraffin-embedded tissue: evaluation in follicular lymphoma
    Yuko Hirose
    Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan
    Int J Hematol 78:154-9. 2003
    ..The t(14;18)(q32;q21) associated with follicular lymphoma juxtaposes a portion of BCL-2 (18q21) and IGH(14q32); the result is bcl-2 overexpression...
  8. ncbi [Pathologic diagnosis and subtyping of lymphoma in bone marrow biopsies using histologic examination, immunohistochemistry and gene rearrangement studies]
    Jia Cheng Xiao
    Department of Pathology, Rui Jin Hospital of Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Bing Li Xue Za Zhi 33:120-4. 2004
    ..To assess the value of histologic examination, immunohistochemistry and gene rearrangement studies in the diagnosis and subtyping of lymphoma with bone marrow involvement (BMI)...
  9. ncbi Interphase fluorescence in situ hybridization is more sensitive than BIOMED-2 polymerase chain reaction protocol in detecting IGH-BCL2 rearrangement in both fixed and frozen lymph node with follicular lymphoma
    Marc Antoine Belaud-Rotureau
    Pathology Laboratory, CHU Bordeaux, 33604 Pessac, France
    Hum Pathol 38:365-72. 2007
    ..With the use of split signal DNA probes, 1 case showed a trisomy of the BCL2 locus and another displayed BCL6 and IGH breakpoints that would suggest a t(3;14)...
  10. pmc Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription?
    Mara L Lennard
    Marine Biomedicine and Environmental Sciences Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    BMC Mol Biol 8:8. 2007
    The enhancer (Emu3') of the immunoglobulin heavy chain locus (IGH) of the channel catfish (Ictalurus punctatus) has been well characterized...
  11. doi t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in stomach: a study of 48 cases
    Guanghua Wang
    Division of Molecular Pathology, Department of Scientific Laboratories, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Mod Pathol 22:79-86. 2009
    ..Of the 48 analyzed cases, 15 (31%) were positive for t(11;18)(q21;q21) and 33 (69%) were monoclonal for IgH gene rearrangement...
  12. ncbi [Clinical significance in detection of immunoglobulin heavy chain clonal rearrangement in bone marrow of patients with B cell lymphoma]
    Zhi yu Chen
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 31:183-8. 2009
    To explore the feasibility of semi-nested PCR technique for detection of immunoglobulin heavy chain (IgH) clonal rearrangement in bone marrow of B-cell lymphoma patient and to further evaluate its clinicopathological value.
  13. doi The immunoglobulin heavy chain locus in the platypus (Ornithorhynchus anatinus)
    F Gambón-Deza
    Vigo University Hospital Complex, Pontevedra, Spain
    Mol Immunol 46:2515-23. 2009
    ..These data and the characterization of the IGH locus in platypus (Ornithorhynchus anatinus), allow us to elucidate the changes that took place in this genomic ..
  14. pmc Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region
    Monica Gostissa
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 462:803-7. 2009
    ..Translocations within Igh involve DNA double-strand breaks initiated either by the RAG1/2 endonuclease during variable, diversity and joining ..
  15. ncbi [Primers for detecting gene rearrangement in different regions of immunoglobulin heavy chain genes and their application in diagnosis of paraffin-embedded lymphoma tissues]
    Zong Li Qi
    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:1964-7. 2008
    ..To analyze and optimize the gene rearrangement primers of different frame regions (FR) of immunoglobulin heavy chain (IgH) genes by bioinformatic methods and explore the application of these primers in the detection of paraffin-embedded ..
  16. ncbi Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization
    L J Chen
    Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029, China
    Exp Oncol 29:116-20. 2007
    ..Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM...
  17. ncbi In multiple myeloma, circulating hyperdiploid B cells have clonotypic immunoglobulin heavy chain rearrangements and may mediate spread of disease
    L M Pilarski
    Department of Oncology, University of Alberta, Edmonton, Canada
    Clin Cancer Res 6:585-96. 2000
    ..Hyperdiploid MM B cells express CD34 and have clonotypic IgH transcripts, confirming them as part of the malignant clone...
  18. ncbi beta-Mercaptoethanol differentially acts on the rat somatotrophs and lactotrophs in primary culture to suppress the secretion of immunoreactive hormones
    K Nakamura
    Second Department of Physiology, School of Medicine, Iwate Medical University, Japan
    Horm Metab Res 26:565-9. 1994
    ..of the structural similarities between PRL and growth hormone (GH), the effects of ME on the hormonal dynamics of iGH were compared to those of iPRL...
  19. ncbi [Comparative study of genetic aberrations in human multiple myeloma cell lines and newly diagnosed MM by fluorescence in situ hybridization]
    Gang An
    Chinese Academy of Medical Sciences, Tianjin 300020, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1505-10. 2010
    ..FISH with LSI IGH/CCND1 , LSI IGH/FGFR3 and LSI IGH/MAF probes were used to detect t(11;14) (q13;q32) , t(4;14) (p16;q32) and t(14;16)..
  20. ncbi Primary burkitt lymphoma of the chest wall
    Rommel Lu
    Department of Medicine, Division of Hematology Medical Oncology, University of Virginia Medical Center, Charlottesville, VA
    Clin Lymphoma Myeloma Leuk 10:E38. 2010
    ..Molecular cytogenetic analysis revealed fusion signals with IgH/Myc t(8;14) dual fusion probe, supporting the diagnosis of BL...
  21. ncbi Abnormal patterns of immunoglobulin heavy chain gene DNA fingerprinting during chronic phase chronic myeloid leukemia
    A Spencer
    Haematology Department, Mater Hospital, Newcastle, Australia
    Leuk Lymphoma 32:299-307. 1999
    Using IgH DNA fingerprinting we have previously demonstrated clonal immunoglobulin heavy chain (IgH) gene rearrangements during chronic phase (CP) chronic myeloid leukemia (CML) in patients destined to develop lymphoid blast crisis (L-BC)...
  22. ncbi The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America
    Ellen D Remstein
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN 55905, USA
    Am J Surg Pathol 30:1546-53. 2006
    ..from diverse anatomic sites were studied by fluorescence in situ hybridization (FISH) using probes for API2-MALT1, IGH-MALT1, IGH-BCL10, IGH-FOXP1, IGH, +/- centromeres 3, 7, 12, and 18, and a subset (n=74) were analyzed using FISH ..
  23. ncbi [Clinicopathologic characteristics and chromosomal abnormalities in salivary mucosa associated lymphoid tissue lymphomas]
    Bai zhou Li
    Department of Pathology, Second Hospital of Zhejiang University Medical College, Hangzhou 310009, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:651-6. 2009
    ..To study the morphological and genetic characteristics in salivary gland marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) lymphomas...
  24. ncbi Mantle cell lymphoma: improved diagnostics using a combined approach of immunohistochemistry and identification of t(11;14)(q13;q32) by polymerase chain reaction and fluorescence in situ hybridization
    Roman Kodet
    Department of Pathology and Molecular Medicine, Charles University, 2nd Medical School and Faculty Hospital in Motol, V Uvalu 84, 150 06, Prague 5 Motol, Czech Republic
    Virchows Arch 442:538-47. 2003
    ..of cyclin D1 due to juxtaposition of the bcl-1 locus (and CCND1 gene coding for the cyclin D1) to the IgH gene. This phenomenon is caused by t(11;14)(q13;q32). The morphological diagnosis of MCL may pose difficulties...
  25. pmc Diverse chemicals including aryl hydrocarbon receptor ligands modulate transcriptional activity of the 3'immunoglobulin heavy chain regulatory region
    Rebecca A Henseler
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA
    Toxicology 261:9-18. 2009
    ..IgH) gene is a sensitive target of TCDD and may be transcriptionally inhibited by TCDD through inhibition of the 3'IgH transcriptional regulatory region (3'IgHRR)...
  26. doi Uncoupling between Ig somatic hypermutation and oncogene mutation in mouse lymphoma
    Christelle Vincent
    UMR CNRS 6101, Centre National de la Recherche Scientifique, Universite de Limoges, France
    Biochim Biophys Acta 1793:418-26. 2009
    ..By inserting a c-myc gene under the control of the 3'IgH locus control region (LCR) into the mouse genome, we generated c-myc-3'LCR mice that develop clonal BL or diffuse ..
  27. pmc The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination
    Karen Featherstone
    Laboratory of Chromatin and Gene Expression, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom
    J Biol Chem 285:9327-38. 2010
    ..We have assembled the sequence of a strategically located 96-kb V-D intergenic region in the mouse Igh and analyzed its activity during lymphocyte development...
  28. doi Minimal residual disease detection in mantle cell lymphoma: methods and significance of four-color flow cytometry compared to consensus IGH-polymerase chain reaction at initial staging and for follow-up examinations
    Sebastian Böttcher
    Second Department of Medicine, Chemnitzstrasse 33, D 24116 Kiel, Germany
    Haematologica 93:551-9. 2008
    ..Data from prospective clinical trials comparing the clinical applicability of flow cytometry to routine diagnostic methods and to polymerase chain reaction are currently lacking...
  29. pmc Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis
    D M Williams
    Audie L Murphy Memorial Veterans Hospital, and Department of Medicine, University of Texas Health Sciences Center at San Antonio, 78284, USA
    Infect Immun 65:2876-82. 1997
    ..CD8+ T-cell function (beta2-microglobulin deficient, MHC class I deficient [Beta2m-/-]), B-cell function (C57BL/10J-Igh(tm1Cgn) [Igh-/-]), and gamma interferon (IFN-gamma) (C57BL/6-Ifg(tm1) [Ifg-/-]) or interleukin-4 (C57BL/6J(tm1Cgn29)..
  30. ncbi Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia
    O J Verhagen
    Department of Immunohematology, Academic Medical Center, University of Amsterdam, The Netherlands
    Leukemia 14:1426-35. 2000
    ..The ASO primer approach reached maximal sensitivities of at least 10(-4) in 33 out of 35 IGH rearrangements...
  31. ncbi Polymerase chain reaction detection of cells carrying t(14;18) in bone marrow of patients with follicular and diffuse large B-cell lymphoma: the importance of analysis at diagnosis and significance of long-term follow-up
    T Papajik
    Department of Hemato Oncology, University Hospital, Olomouc, Czech Republic
    Neoplasma 48:501-5. 2001
    ..The bcl-2/IgH rearrangement constitutes good target for polymerase chain reaction (PCR) detection that allows to find out one ..
  32. ncbi Differential response to H. pylori eradication therapy of co-existing diffuse large B-cell lymphoma and MALT lymphoma of stomach-significance of tumour cell clonality and BCL10 expression
    S H Kuo
    Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Pathol 211:296-304. 2007
    ..clonality of lymphoma cells was examined by polymerase chain reaction-based amplification of the CDR3 region of the IgH gene and confirmed by DNA sequence analysis. BCL10 expression was determined by immunohistochemistry...
  33. ncbi Structure and organization of the immunoglobulin M heavy chain genes in Atlantic salmon, Salmo salar
    I Hordvik
    Department of Fisheries and Marine Biology, High Technology Center, University of Bergen, Norway
    Mol Immunol 34:631-9. 1997
    ..Two closely related IgH constant region genes, CHA and CHB, have been sequenced completely...
  34. pmc Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer
    Danjuan Lin
    Section of Molecular Genetics and Microbiology and Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas, USA
    Mol Cancer 6:23. 2007
    ..Bright positively activates IgH transcriptional initiation by binding to ATC-rich P sites within nuclear matrix attachment regions (MARs) flanking ..
  35. doi Fluorescence immunophenotypic and interphase cytogenetic characterization of nodal lymphoplasmacytic lymphoma
    Rachel Lynn Sargent
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1643-53. 2008
    ..Cases with IgH R were further studied with an IgH/BCL2 probe...
  36. ncbi [A clinical study of chromosome translocations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Chinese patients]
    Ge Hong Dong
    Department of Pathology, Health Science Center, Peking University, Beijing 100191, China
    Zhonghua Nei Ke Za Zhi 48:181-5. 2009
    ..To investigate the genetic aberrations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphomas from different sites of the body in Chinese patients...
  37. ncbi Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP
    C Roman
    Department of Biological Chemistry, University of California, Los Angeles
    Genes Dev 4:1404-15. 1990
    ..A fusion protein encoded by the cDNA binds specifically to muEBP-E-binding sites (E sites) in both the IgH enhancer and the VH1 promoter...
  38. doi Replacement of Imu-Cmu intron by NeoR gene alters Imu germ-line expression but has no effect on V(D)J recombination
    Dania Haddad
    CNRS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Equipe Instabilité génétique et régulation transcriptionnelle, 205 route de Narbonne, 31077 Toulouse, France
    Mol Immunol 47:961-71. 2010
    ..This polarized long-range effect of the 3'RR is disturbed upon insertion of NeoR gene in the IgH constant (C(H)) region, where only GL transcription derived from upstream GL promoters is impaired...
  39. pmc Anti-insulin receptor autoantibodies are not required for type 2 diabetes pathogenesis in NZL/Lt mice, a New Zealand obese (NZO)-derived mouse strain
    Marcia F McInerney
    Department of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy, Toledo, OH 43606, USA
    Exp Diabesity Res 5:177-85. 2004
    ..pathogenic contributions of B lymphocytes and AIRAs in this model, a disrupted immunoglobulin heavy chain gene (Igh-6) congenic on the NZB/BlJ background was backcrossed 4 generations into the NZO/HlLt background and was then ..
  40. pmc BOB.1 of the channel catfish, Ictalurus punctatus: not a transcriptional coactivator?
    Mara L Lennard Richard
    Marine Biomedicine and Environmental Sciences Center, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Immunol 46:481-91. 2009
    ..is an activator of transcription, catfish Oct1 failed to drive transcription and may act as a negative regulator of IGH transcription. In mammals, the Oct co-activator BOB...
  41. ncbi IgH class switching and translocations use a robust non-classical end-joining pathway
    Catherine T Yan
    Howard Hughes Medical Institute, of Genetics, Boston, Massachusetts 02115, USA
    Nature 449:478-82. 2007
    ..C-NHEJ indeed catalyses CSR joins, because C-NHEJ-deficient B cells had decreased CSR and substantial levels of IgH locus (immunoglobulin heavy chain, encoded by Igh) chromosomal breaks...
  42. pmc Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
    Hwei Ling Cheng
    Howard Hughes Medical Institute, The Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:2717-22. 2009
    ..class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (S) regions and Ig variable region (V) exons...
  43. ncbi T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
    Berthold Streubel
    Department of Pathology, Division of Oncology, Vienna General Hospital, University of Vienna, Vienna, Austria
    Blood 101:2335-9. 2003
    ..Among a total of 66 cases, t(14;18)(q32;q21) involving IGH and MALT1 was detected in MALT lymphomas of the liver (4 of 4), skin (3 of 11), ocular adnexa (3 of 8), and salivary ..
  44. ncbi A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
    R Richelda
    Laboratorio di Ematologia Sperimentale e Genetica Molecolare, Servizio di Ematologia, Universita degli Studi di Milano, Ospedale Maggiore IRCCS, Milano, Italy
    Blood 90:4062-70. 1997
    ..the linkage analysis of the joining (J) and the constant (C) mu, alpha, and gamma regions to detect cases bearing IGH switch-mediated chromosomal translocations...
  45. ncbi Evaluation of B-cell clonality in archival skin biopsy samples of cutaneous B-cell lymphoma by immunoglobulin heavy chain gene polymerase chain reaction
    Ansgar Lukowsky
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Germany
    Leuk Lymphoma 47:487-93. 2006
    ..were amplified by the Biomed-2 IgH-PCR protocols as well as using four other assays, priming also the three IgH framework regions (FR) 1-3. All PCR products were analysed by fluorescence fragment analysis...
  46. pmc In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development
    Yi Yan
    Department of Biological Sciences, Hunter College and Graduate Center of the City University of New York, New York, NY, USA
    Genes Chromosomes Cancer 46:950-9. 2007
    ..involving the heavy chain locus (IGH) place the MYC gene either in cis with both the intronic enhancer Emu and the IGH 3' regulatory region (3'RR) or in cis with only the 3'RR. The result is deregulated MYC expression...
  47. doi Comparative analysis of immunoglobulin polymerase chain reaction and flow cytometry in fine needle aspiration biopsy differential diagnosis of non-Hodgkin B-cell lymphoid malignancies
    Alicia Maroto
    Departamento de Anatomía Patológica del Hospital Universitario 12 de Octubre de Madrid, Espana
    Diagn Cytopathol 37:647-53. 2009
    ..The adjunctive values of a single primer pair PCR amplification of IgH genes and of the immunophenotyping by flow cytometry were evaluated comparing their results with the final ..
  48. pmc Immunoglobulin heavy chain exclusion in the shark
    Karolina Malecek
    Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York, United States of America
    PLoS Biol 6:e157. 2008
    ..Sharks have an IgH locus organization consisting of 15-200 independently rearranging miniloci (VH-D1-D2-JH-Cmu), a gene organization ..
  49. ncbi Evolution of the immunoglobulin heavy chain class switch recombination mechanism
    Jayanta Chaudhuri
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Adv Immunol 94:157-214. 2007
    ..b>IgH CSR occurs within and requires large, repetitive sequences, termed S regions, which are parts of germ line ..
  50. doi Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Jpn J Ophthalmol 53:209-14. 2009
    ..To determine whether a diagnosis of intraocular lymphoma (IOL) can be made using a combination of polymerase chain reaction (PCR) analysis to detect gene rearrangement of immunoglobulin and cytokine concentrations in the vitreous fluid...
  51. ncbi Secondary ocular involvement in systemic "memory" B-cell lymphocytic leukemia
    S E Coupland
    Department of Pathology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
    Ophthalmology 108:1289-95. 2001
    ..on the basis of the presence of somatic mutations in the variable region of the immunoglobulin heavy chain gene (IgH)...
  52. ncbi Deletion mapping of the mouse ornithine decarboxylase-related locus Odc-rs8 within Igh-V
    B A Richards-Smith
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263
    Mamm Genome 3:568-74. 1992
    ..In the present study, alleles at Odc-rs8 were shown to cosegregate with those for Igh variable region (Igh-V or VH) genes among 37 inbred mouse strains that had been characterized previously for their ..
  53. ncbi High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes
    Peter Goebel
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:2477-87. 2002
    ..with the MAR-binding proteins cut-like protein x/CCAAT-displacement protein (Cux/CDP), B cell regulator of IgH transcription (Bright), and special AT-rich sequence-binding protein (SATB1) by EMSA...
  54. ncbi Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    L Madisen
    Hutchinson Cancer Center, University of Washington School of Medicine, Seattle 98104
    Genes Dev 8:2212-26. 1994
    ..Translocation events between c-myc and the IgH locus segregate c-myc and the IgH intron enhancer to different reciprocal products in all plasmacytomas and in most ..
  55. ncbi An unbalanced translocation involving chromosome 14 is the probable cause for loss of potentially functional rearranged immunoglobulin heavy chain genes in the Epstein-Barr virus-positive Hodgkin's lymphoma-derived cell line L591
    Martina Vockerodt
    Department of Internal Medicine I, Universitity of Cologne, Cologne, Germany
    Br J Haematol 119:640-6. 2002
    ..As in other cases only one non-productive IgH chain gene rearrangement was amplified from H-RS cells, it was speculated whether, in these cases, the functionally ..
  56. pmc Improvements to B cell clonality analysis using PCR amplification of immunoglobulin light chain genes
    T C Diss
    Histopathology Department, Royal Free and University College Medical School, University Street, London WC1E 6JJ, UK
    Mol Pathol 55:98-101. 2002
    Clonality analysis using polymerase chain reaction (PCR) amplification of the immunoglobulin heavy chain (IgH) gene is an important aid to the diagnosis of B cell lymphoproliferative diseases...
  57. ncbi Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice
    Sung Sup Park
    Laboratory of Genetics, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:1306-15. 2005
    ..We conclude that Myc(His) insertion into Igh predictably induces B-cell and plasma-cell tumors in mice, providing a valuable mouse model for understanding the ..
  58. ncbi Bone marrow trephines containing lymphoid aggregates from patients with rheumatoid and other autoimmune disorders frequently show clonal B-cell infiltrates
    Knut Engels
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt M, Germany
    Hum Pathol 38:1402-11. 2007
    ..5 patients with rheumatoid or other autoimmune disorders, were analyzed by morphology, immunohistochemistry, IGH gene rearrangement (polymerase chain reaction), and DNA sequence analysis in selected cases. In 22 (68...
  59. doi Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis
    Francesco Cavazzini
    Section of Haematology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy
    Br J Haematol 142:529-37. 2008
    ..e. +12, 6q-, 1-2 anomalies), group 3 (unfavourable, i.e. 17p-, 11q-, complex karyotype), or group 4 (14q32/IGH translocation). Endpoints were treatment-free survival (TFS) and overall survival (OS)...
  60. doi Phenotyping studies of clonotypic B lymphocytes from patients with multiple myeloma by flow cytometry
    E Joseph Conway
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Arch Pathol Lab Med 133:1594-9. 2009
    Clonotypic B lymphocytes, monoclonal B lymphocytes sharing identical, rearranged IGH-CDR3 sequences with the patient's myeloma cells, have been detected in the peripheral blood of patients with multiple myeloma...
  61. doi [Chromosome study on chronic lymphocytic leukemia using CpG-oligodeoxynucleotide as immunostimulant agent]
    Yafang Wu
    The First Affiliated Hospital, Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu, 215006 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:86-91. 2010
    ..To investigate whether CpG-oligodeoxynucleotide (CpG-ODN) can improve the detection rate of the karyotypic abnormalities in chronic lymphocytic leukemia (CLL)...
  62. ncbi Discovery of a novel immunoglobulin heavy chain gene chimera from common carp (Cyprinus carpio L.)
    Ram Savan
    Faculty of Agriculture, University of Miyazaki, Gakuen kibanadai Nishi 1 1, Miyazaki, 889 2192, Japan
    Immunogenetics 57:458-63. 2005
    ..Recently, a new IGH isotype specific to teleosts had been identified from zebra fish, rainbow trout, and fugu...
  63. pmc A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma
    Hakim Bouamar
    Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Blood 122:726-33. 2013
    ..However, existing methodologies for the detection of IGH translocations are labor intensive, often require viable cells, and are biased toward known IGH fusions...
  64. ncbi A mature T lymphocyte marker closely linked to Igh-1 that is expressed on the precursor for the suppressor T cell regulating a primary response to SRBC
    F L Owen
    J Immunol 124:1411-7. 1980
    The product of a new genetic locus closely linked to Igh-1 in the mouse has previously been shown to be expressed on T cells by using an in vitro fluorescent antibody assay...
  65. ncbi Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma
    Silvia Montoto
    Hematology Department, Institute of Hematology and Oncology, Postgraduate School of Hematology Farrers Valenti Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Leuk Lymphoma 44:71-6. 2003
    Bcl-2/IgH rearrangement is the molecular hallmark of follicular lymphoma (FL) which is present in 70-90% of the cases at diagnosis. The clinical significance of this feature is controversial...
  66. pmc Changes in replication, nuclear location, and expression of the Igh locus after fusion of a pre-B cell line with a T cell line
    Jie Zhou
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:2317-20. 2005
    We have previously observed that replication and nuclear location of the murine Igh locus are developmentally regulated during B cell differentiation...
  67. doi Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire
    Jasna Medvedovic
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Immunity 39:229-44. 2013
    ..VH-DJH recombination by juxtaposing distal VH genes next to the DJH-rearranged gene segment in the 3' proximal Igh domain...
  68. pmc Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition
    Cheng Peng
    Department of Biological Sciences, Hunter College and The Graduate Center of City University of New York, New York, NY 10065
    J Immunol 191:4399-411. 2013
    ..for allelic exclusion that occurs at the pre-B cell to immature B cell transition and is dependent upon the IgH intronic enhancer, Eμ...
  69. doi Usefulness of IGH/TCR PCR studies in lymphoproliferative disorders with inconclusive clonality by flow cytometry
    Jordi Ribera
    IJC Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autonoma de Barcelona
    Cytometry B Clin Cytom 86:25-31. 2014
    ..We analyzed IGH and TCRγ genes by PCR in 106 samples with inconclusive FCM results...
  70. ncbi Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice
    Paul Szabo
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Immunol 222:78-87. 2003
    ..We have demonstrated both decreased rearrangement of the V to DJ IgH gene segments and low levels of VH germline transcripts in Pro-B cells, the precursors of Pre-B cells, from old ..
  71. ncbi Use of a simple, general targeting vector for replacing the DNA of the heavy chain constant region in mouse hybridoma cells
    Diana Ronai
    Immunology Department, University of Toronto, Toronto, ON, Canada M5S 1A8
    J Immunol Methods 275:191-202. 2003
    ..DNA segments from the JH-S micro region and from the region 3' of Calpha are normally present in the functional IgH gene of all hybridomas, regardless of the heavy chain class which is expressed...
  72. ncbi Rapid diagnosis of clonal immunoglobulin heavy chain gene rearrangements in cutaneous B-cell lymphomas using the LightCycler-Polymerase Chain Reaction with DNA melting curve analysis
    Dongsheng Xu
    Department of Pathology, Albert Einstein College of Medicine Montefiore Medical Center, Bronx, New York 10467, USA
    Am J Dermatopathol 26:385-9. 2004
    We have recently developed a novel Immunoglobulin heavy chain gene rearrangement (IgH-R) assay that combines polymerase chain reaction (PCR) amplification and analysis in the same closed capillary tube using the LightCycler System...
  73. ncbi Allelic polymorphism of murine IgE controlled by the seventh immunoglobulin heavy chain allotype locus
    M S Borges
    Immunogenetics 13:499-507. 1981
    ..raised in BALB/c mice against monoclonal IgE of C57BL/6 origin reacted exclusively with IgE of strains having Igh-1b (IgG2 a) allotype...
  74. ncbi Correlation between presence of clonal rearrangements of immunoglobulin heavy chain genes and B-cell antigen expression in Hodgkin's disease
    A Orazi
    Division of Hematopathology, Indiana University School of Medicine, Indianapolis, USA
    Am J Clin Pathol 104:413-8. 1995
    ..b>IgH gene rearrangement was present in 8 of 15 (53%) NSHD and in 1 of 3 (33%) MCHD...
  75. ncbi Discovery of a new class of immunoglobulin heavy chain from fugu
    Ram Savan
    Laboratory of Marine Biotechnology, Faculty of Agriculture, Miyazaki, Japan
    Eur J Immunol 35:3320-31. 2005
    ..In this study, we report the discovery of a new class of IgH from fugu. This isotype was first identified from the genomic sequence of the fugu IgH locus...
  76. doi Immunoglobulin heavy chain (IGH@) translocations negatively impact treatment-free survival for chronic lymphocytic leukemia patients who have an isolated deletion 13q abnormality
    Alina S Gerrie
    Division of Hematology, University of British Columbia, Vancouver, Canada
    Cancer Genet 205:523-7. 2012
    Immunoglobulin heavy chain translocations (t(IGH@)) are suggested to portend a poor prognosis in chronic lymphocytic leukemia (CLL)...
  77. ncbi PCR detection of residual Bcl-2/IgH-positive cells after high-dose therapy with autologous stem cell transplantation is a prognostic factor for event-free survival in patients with low-grade follicular non-Hodgkin's lymphoma
    B Mahe
    Service d Hematologie, Centre Hospitalier Universitaire Nantes, France
    Bone Marrow Transplant 31:467-73. 2003
    ..PCR amplification of the Bcl-2/IgH rearrangement was performed at diagnosis, on stem cell collections before and after purging and on bone marrow and ..
  78. doi Shaping of human germline IgH repertoires revealed by deep sequencing
    Kevin Larimore
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 189:3221-30. 2012
    ..the benefits of Ig repertoire diversity with the risks of autoreactivity and nonfunctionality of highly variable IgH CDR3s, we collected millions of rearranged germline IgH CDR3 sequences by deep sequencing of DNA from mature human ..
  79. pmc Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase
    Muneer G Hasham
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 189:2374-82. 2012
    Activation-induced cytidine deaminase (AID) initiates DNA double-strand breaks (DSBs) in the IgH gene (Igh) to stimulate isotype class switch recombination (CSR), and widespread breaks in non-Igh (off-target) loci throughout the genome...
  80. doi Cloned IGH VDJ targets as tools for personalized minimal residual disease monitoring in mature lymphoid malignancies; a feasibility study in mantle cell lymphoma by the Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang
    Estelle Gimenez
    INSERM U823, Institut Albert Bonniot, Grenoble, France
    Br J Haematol 158:186-97. 2012
    ..Current EuroMRD consensus IGH real-time quantitative polymerase chain reaction RQ-PCR assays rely on flow cytometric assessment of diagnostic ..
  81. pmc Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus
    Sabrina A Volpi
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 188:2556-66. 2012
    Regulatory elements located within an ∼28-kb region 3' of the Igh gene cluster (3' regulatory region) are required for class switch recombination and for high levels of IgH expression in plasma cells...
  82. ncbi The CBFA2T3/ACSF3 locus is recurrently involved in IGH chromosomal translocation t(14;16)(q32;q24) in pediatric B-cell lymphoma with germinal center phenotype
    Itziar Salaverria
    Institute of Human Genetics, University Hospital Schleswig Holstein Campus Kiel Christian Albrechts University, Kiel, Germany
    Genes Chromosomes Cancer 51:338-43. 2012
    ..In case of a breakpoint in the IGH switch region, oncogene activation can take place on both derivative chromosomes, which means that in principle one ..
  83. doi The immunoglobulin gene loci in the teleost Gasterosteus aculeatus
    Yonghua Bao
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China
    Fish Shellfish Immunol 28:40-8. 2010
    ..The IgH gene locus is arranged in a configuration of (V(n)-D-J-C(zeta)-D(3)-J(4)-C(mu)-C(delta))(3)-V(6)-D-J-C(zeta), which ..
  84. ncbi Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes
    J V Ravetch
    Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, Maryland 20205
    Cell 27:583-91. 1981
    ..A comparison of the structures of these D regions raises the possibility that they are mosaics formed by recombination between D segments...
  85. doi Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma
    Luba Trakhtenbrot
    Division of Hematology and the Sheba Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Genes Chromosomes Cancer 49:17-27. 2010
    ..major attention was drawn to the significance of chromosomal aberrations involving chromosome arm 13q and the IGH region on chromosome band 14q32 as a prognostic indicator in MM...
  86. ncbi A complete map of the human immunoglobulin VH locus
    I M Tomlinson
    MRC Centre for Protein Engineering, Cambridge, United Kingdom
    Ann N Y Acad Sci 764:43-6. 1995
  87. doi Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes
    Christelle Vincent-Fabert
    Unité Mixte de Recherche Centre National de la Recherche Scientifique, Universite de Limoges, 2 rue du Dr Marcland, Limoges Cedex, France
    Blood 116:1895-8. 2010
    ..Finally, plasma cell differentiation strongly boosts IgH transcription. How the multiple IgH transcriptional enhancers tune these changes is unclear...
  88. pmc Frequent T and B cell oligoclones in histologically and immunophenotypically characterized angioimmunoblastic lymphadenopathy
    J L Smith
    Molecular Immunology Group of the Wessex Immunology Service, Department of Pathology, Southampton University Hospitals National Health Service Trust, Southampton, United Kingdom
    Am J Pathol 156:661-9. 2000
    ..first described as a nonneoplastic proliferation associated with immunodeficiency, the heterogeneity of TCR and IgH gene rearrangements suggest that some cases may harbor multiple lymphoid clones...
  89. pmc Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia
    Michael J Brisco
    Department of Hematology and Genetic Pathology, Flinders University and Medical Centre, Adelaide, Australia
    J Mol Diagn 11:194-200. 2009
    ..significantly more markers for the major leukemic clone than did the conventional strategy, and one or more IgH rearrangements that were suitable for monitoring the major clone were detected in 96% of children and 94% of adults...
  90. ncbi Immunoglobulin/Myc recombinations in murine Peyer's patch follicles
    J R Muller
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Genes Chromosomes Cancer 20:1-8. 1997
    ..Here we describe for the first time a PCR-based technique for detecting fusions between Igh mu or Igh alpha and Myc in situ. Igh/Myc recombinations were found in transplanted and primary plasmacytomas...
  91. doi Splenic marginal zone lymphoma: Clinical clustering of immunoglobulin heavy chain repertoires
    Luca Arcaini
    Division of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia Viale C Golgi 19, 27100 Pavia, Italy
    Blood Cells Mol Dis 42:286-91. 2009
    ....
  92. doi JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation coexist, but originate from separate clones
    Junya Kuroda
    Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Acta Haematol 120:177-81. 2008
    ....
  93. doi CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation
    Xiao Tong Hu
    Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Blood 115:2458-61. 2010
    ..polymerase chain reaction, we identified CD44, located on chromosome 11p13, as a novel translocation partner of IGH in 9 of 114 cases of gastric, nongastric extranodal, follicular, and nodal diffuse large B-cell lymphoma (DLBCL)...
  94. doi Identification of IGHCδ-BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B-cell lymphoma/leukemia
    Satoru Kobayashi
    Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Genes Chromosomes Cancer 50:207-16. 2011
    ..Fluorescence in situ hybridization analysis using an IGH/MYC probe detected an IGH-MYC fusion signal on der(14) and IGH signal on del(6)...
  95. ncbi Immunogenetic influence of Igh-1 phenotype on experimental herpes simplex virus type-1 corneal infection
    E M Opremcak
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114
    Invest Ophthalmol Vis Sci 29:749-54. 1988
    Patterns of herpes simplex virus type-1 (HSV-1) infection were studied in BALB/c congenic, Igh-1 disparate murine strains to establish the influence of Igh-1 phenotype on the development of keratopathy, trigeminal ganglionic latency and ..
  96. doi Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody
    Yuniel Fernández-Marrero
    Department of Immunobiology, Center of Molecular Immunology, P O Box 16040, Havana 11600, Cuba
    Mol Immunol 48:1059-67. 2011
    ..Unlike 14F7 mAb, the cytotoxicity of the P3 E(99)→R mutant antibody did not exclusively depend on ganglioside expression on tumor cells...
  97. doi Various patterns of IgH deletion identified by FISH using combined IgH and IgH/CCND1 probes in multiple myeloma and chronic lymphocytic leukemia
    Y Hwang
    Department of Laboratory Medicine, Ewha Womans University School of Medicine, Seoul, Korea
    Int J Lab Hematol 33:299-304. 2011
    ..In this study, the characteristics and frequency of the IgH deletion identified by interphase FISH were investigated in patients with multiple myeloma (MM) and chronic ..
  98. doi Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia
    Elisa Sozzi
    Sezione and Unità di Ematologia, Università di Siena and AOUS, Italy
    Hematol Oncol 29:31-7. 2011
    ..gene (IG) heavy (H) and light chains show heterogeneity of mutational status, but reveal common features of ongoing IGH isotype-switching with multiple IGH isotype expression and preference of IG lambda (IGL) light chain with selective ..
  99. ncbi Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A
    Inka Pawlitzky
    Immunology Program, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 176:6839-51. 2006
    The Igh locus is controlled by cis-acting elements, including Emu and the 3' IgH regulatory region which flank the C region genes within the well-studied 3' part of the locus...
  100. doi Hydrogen peroxide modulates immunoglobulin expression by targeting the 3'Igh regulatory region through an NFκB-dependent mechanism
    Eric J Romer
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio 45435, USA
    Free Radic Res 45:796-809. 2011
    ..b>Igh transcription in B lymphocytes is an essential step in antibody production and is governed through a complex ..
  101. pmc Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor
    Bruce D Wines
    Centre for Immunology, The Burnet Institute, Melbourne 3004, Australia
    J Biol Chem 286:33118-24. 2011
    ....

Research Grants104 found, 100 shown here

  1. Immunoglobulin Constant Region Switch and Hypermutation in the Nurse Shark
    Ellen Hsu; Fiscal Year: 2010
    ..This genetic exchange occurs somatically and between distantly located IgH genes;it resembles the H chain switch recombination that exists in mammals...
  2. Immunoglobulin Constant Region Switch and Hypermutation in the Nurse Shark
    Ellen Hsu; Fiscal Year: 2009
    ..This genetic exchange occurs somatically and between distantly located IgH genes; it resembles the H chain switch recombination that exists in mammals...
  3. Immunoglobulin Constant Region Switch and Hypermutation in the Nurse Shark
    Ellen Hsu; Fiscal Year: 2010
    ..This genetic exchange occurs somatically and between distantly located IgH genes;it resembles the H chain switch recombination that exists in mammals...
  4. Transcriptional Functions and Targets of the MMSET Protein of t(4:14) Myeloma
    Jonathan D Licht; Fiscal Year: 2010
    ..based upon the characterization of consistent chromosomal translocations involving the immunoglobulin heavy chain (IgH). These translocations implicate particular genes in the pathogenesis of myeloma...
  5. EXPRESSION OF IMMUNOGLOBULIN HEAVY CHAIN GENES
    KENNETH MARCU; Fiscal Year: 1992
    ..Finally, we plan to clone Igh switch-recombinase gene(s) from a mammalian expression vector cDNA library by a convenient, selectable rescue ..
  6. Duck Antibody Genes: Unusual Organization and Expression
    Gregory Warr; Fiscal Year: 2003
    ..class-switching, by transcription from I-exon promoters, been conserved in vertebrate evolution? 3) The mammalian IgH locus contains transcriptional enhancers in both the JH to mu intron and 3' of the C-gene cluster...
  7. Duck Antibody Genes: Unusual Organization and Expression
    Gregory Warr; Fiscal Year: 2006
    ..class-switching, by transcription from I-exon promoters, been conserved in vertebrate evolution? 3) The mammalian IgH locus contains transcriptional enhancers in both the JH to mu intron and 3' of the C-gene cluster...
  8. Duck Antibody Genes: Unusual Organization and Expression
    Gregory Warr; Fiscal Year: 2007
    ..class-switching, by transcription from I-exon promoters, been conserved in vertebrate evolution? 3) The mammalian IgH locus contains transcriptional enhancers in both the JH to mu intron and 3' of the C-gene cluster...
  9. TRANSCRIPTION OF IMMUNOGLOBULIN HEAVY CHAIN GENES
    Kathryn Calame; Fiscal Year: 2001
    DESCRIPTION (Adapted from Investigator's abstract): Elucidating IgH transcriptional regulation is critical for understanding how the humoral immune response is controlled...
  10. MAPPING CHROMOSOMES AND GENES IN RELATION TO LEUKEMIA
    Raju Chaganti; Fiscal Year: 2000
    ..b>IGH gene probes will be utilized in Southern blotting and library screening to identify non01G rearranged fragments from ..
  11. Role of CTCF and Cohesin in V(D)J Rearrangement
    Ann J Feeney; Fiscal Year: 2010
    ..The IgH locus contains over 100 functional Vh genes spanning a 2.5 Mb region...
  12. ACTIVATION OF BCL-2 IN HEMATOLOGIC MALIGNANCIES
    LINDA BOXER; Fiscal Year: 2009
    ..We have investigated how the translocated bcl-2 gene is deregulated by the IgH locus and have identified regulatory sites in the bcl-2 promoter and in the 3' IgH enhancers...
  13. ACTIVATION OF BCL-2 IN HEMATOLOGIC MALIGNANCIES
    Linda M Boxer; Fiscal Year: 2010
    ..We have investigated how the translocated bcl-2 gene is deregulated by the IgH locus and have identified regulatory sites in the bcl-2 promoter and in the 3'IgH enhancers...
  14. Role of CTCF and Cohesin in V(D)J Rearrangement
    Ann J Feeney; Fiscal Year: 2010
    ..The IgH locus contains over 100 functional Vh genes spanning a 2.5 Mb region...
  15. Activation of BCL-2 in Hematologic Malgnancies
    LINDA BOXER; Fiscal Year: 2007
    ..We have investigated how the translocated bcl-2 gene is deregulated by the IgH locus and have identified regulatory sites in the bcl-2 promoter and in the 3' IgH enhancers...
  16. ACTIVATION OF BCL-2 IN HEMATOLOGIC MALIGNANCIES
    LINDA BOXER; Fiscal Year: 2006
    ..We postulate that the IgH enhancers maintain the bcl-2 promoter in an open transcriptional conformation through the recruitment of histone ..
  17. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2010
    ..However, translocations do occur between oncogenes and the IgH locus, and this can lead to B cell lymphomas...
  18. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2010
    ..However, translocations do occur between oncogenes and the IgH locus, and this can lead to B cell lymphomas...
  19. Role of the BCR in B Cell Chronic Lymphocytic Leukemia
    Diane F Jelinek; Fiscal Year: 2010
    ..that the use of specific immunoglobulin heavy chain variable region (IGHV) genes in CLL is non-random and the IGH complementarity determining region 3 (CDR3) is remarkably homologous in certain CLL patients...
  20. Role of the BCR in B Cell Chronic Lymphocytic Leukemia
    Diane Jelinek; Fiscal Year: 2009
    ..that the use of specific immunoglobulin heavy chain variable region (IGHV) genes in CLL is non-random and the IGH complementarity determining region 3 (CDR3) is remarkably homologous in certain CLL patients...
  21. MALIGNANT STEM CELL IN MULTIPLE MYELOMA
    Linda Pilarski; Fiscal Year: 2001
    ..the cell types that comprise the malignant B lineage hierarchy of MM, as defined by their expression of clonotypic IgH VDJ transcripts, in blood, bone marrow and in the G-CSF mobilized blood used for transplantation...
  22. Gene Expression in Myeloma Cells
    Laurel A Eckhardt; Fiscal Year: 2010
    ..Further study of the regulatory elements in the IgH locus, therefore, must be an essential component of any effort aimed at treating and/or preventing B-lineage cancers,..
  23. Gene Expression in Myeloma Cells
    LAUREL ECKHARDT; Fiscal Year: 2009
    ..Further study of the regulatory elements in the IgH locus, therefore, must be an essential component of any effort aimed at treating and/or preventing B-lineage cancers,..
  24. Gene Expression in Myeloma Cells
    LAUREL ECKHARDT; Fiscal Year: 2007
    ..Further study of the regulatory elements in the IgH locus, therefore, must be an essential component of any effort aimed at treating and/or preventing B-lineage cancers,..
  25. ASSEMBLY & EXPRESSION OF IG & TCR VARIABLE REGION GENES
    Frederick Alt; Fiscal Year: 2009
    ..Over the past 5 years, we used gene- targeted mutation to "tailor" endogenous TCR(3 and IgH loci in mice to make amenable experimental systems...
  26. ASSEMBLY & EXPRESSION OF IG & TCR VARIABLE REGION GENES
    FREDERICK WAYNE ALT; Fiscal Year: 2010
    ..Over the past 5 years, we used gene- targeted mutation to "tailor" endogenous TCR(3 and IgH loci in mice to make amenable experimental systems...
  27. ASSEMBLY & EXPRESSION OF IG & TCR VARIABLE REGION GENES
    Frederick Alt; Fiscal Year: 2007
    ..Over the past 5 years, we used gene- targeted mutation to "tailor" endogenous TCR(3 and IgH loci in mice to make amenable experimental systems...
  28. Mouse models of age-associated monoclonal gammopathy
    PETER BERGSAGEL; Fiscal Year: 2007
    ..Using interphase FISH, IgH translocations are detected with a similar frequency in the pre-malignant MGUS...
  29. Gene Expression in Myeloma Cells
    LAUREL ECKHARDT; Fiscal Year: 2005
    ..These events include assembly of variable region (VH) coding sequences, activation of the IgH promoter, heavy chain class switch recombination (CSR), somatic hypermutation, and a shift from membrane to secreted ..
  30. Regulation of IgH chain gene expression in B lymphocytes
    Dorothy Yuan; Fiscal Year: 2004
    ..These studies should provide further insight into the longstanding enigma of dual receptor expression on B lymphocytes. ..
  31. Defining Growth Hormone Actions in Bone
    Thomas Clemens; Fiscal Year: 2007
    ..or deficient in the IGF-1 receptor to characterize GHR signaling components and explore the concept of GH/IGH-1 collaboration by comparing the effects of GH on osteoblast proliferation, matrix deposition and differentiated ..
  32. Defining Growth Hormone Actions in Bone
    Thomas Clemens; Fiscal Year: 2005
    ..or deficient in the IGF-1 receptor to characterize GHR signaling components and explore the concept of GH/IGH-1 collaboration by comparing the effects of GH on osteoblast proliferation, matrix deposition and differentiated ..
  33. Somatic hypermutation and class switching in autoimmunity
    Paolo Casali; Fiscal Year: 2010
    ..CSR replaces the expressed IgH constant (CH) region, e.g...
  34. Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLE
    Zhixin Zhang; Fiscal Year: 2009
    ..Our initial analyses of 193 IgH genes derived from SLE plasma cells and naove B cells revealed many features of autoantibodies, such as long CDR3 ..
  35. Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLE
    Zhixin Zhang; Fiscal Year: 2010
    ..Our initial analyses of 193 IgH genes derived from SLE plasma cells and naove B cells revealed many features of autoantibodies, such as long CDR3 ..
  36. Molecular Mechanisms of Class Switch Recombination
    FREDERICK WAYNE ALT; Fiscal Year: 2010
    ..For these studies, we developed targeted mutation assays to replace endogenous IgH class switch (S) regions and exons encoding IgH variable regions with test sequences that will allow us to determine ..
  37. Polysaccharide Antibody Repertoires
    Alexander H Lucas; Fiscal Year: 2010
    ..Our in vitro studies indicate that IgH allelic polymorphisms can dramatically influence PS Ab function...
  38. DNA REPLICATION INITIATION SITES IN MAMMALIAN CELLS
    Carl Schildkraut; Fiscal Year: 2007
    ..In cells in the early stages of development the entire Igh locus replicates early in the S phase, while in the late stages part of the locus replicates later in S phase...