IGFBP1

Summary

Gene Symbol: IGFBP1
Description: insulin-like growth factor binding protein 1
Alias: AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, IBP-1, IGF-binding protein 1, IGFBP-1, alpha-pregnancy-associated endometrial globulin, amniotic fluid binding protein, binding protein-25, binding protein-26, binding protein-28, growth hormone independent-binding protein, insulin-like growth factor-binding protein 1, placental protein 12
Species: human

Top Publications

  1. ncbi Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease
    G E Krassas
    Department of Endocrinology and Metabolism, Panagia General Hospital, 55132 Thessaloniki, Greece
    J Clin Endocrinol Metab 88:132-5. 2003
  2. pmc Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:3095-109. 2007
  3. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
  4. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
  5. ncbi Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes
    Pamela J Goodwin
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Breast Cancer Res Treat 74:65-76. 2002
  6. doi Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction
    Maria Koutsaki
    Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion, Crete, Greece
    Growth Horm IGF Res 21:31-6. 2011
  7. ncbi Reduced IGFBP-1 is associated with thickening of the carotid wall in type 2 diabetes
    Eeva S Leinonen
    Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 25:1807-12. 2002
  8. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
  9. ncbi Polymorphisms in IGF-binding protein 1 are associated with impaired renal function in type 2 diabetes
    Richard H Stephens
    Vascular Research Group, Hope Hospital, Salford, UK
    Diabetes 54:3547-53. 2005
  10. doi Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age
    Danielle van der Kaay
    Department of Pediatrics, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:1386-92. 2009

Research Grants

  1. MOLECULAR REGULATION OF IGF BINDING PROTEIN 1
    Terry Unterman; Fiscal Year: 1999
  2. REVERSAL OF DECLINE OF GH SECRETION OF AGING
    Michael Thorner; Fiscal Year: 2002
  3. Obesity and Diabetes Familial Risk in Hispanic Children
    Nancy F Butte; Fiscal Year: 2010
  4. MOLECULAR REGULATION OF IGF BINDING PROTEIN 1
    Terry Unterman; Fiscal Year: 2003
  5. Modulators of liver injury
    JULIE I JU LEU; Fiscal Year: 2007
  6. p53 and pathways of apoptosis
    DONNA GEORGE; Fiscal Year: 2007
  7. Treatment of Breast Cancer with IGFBP1
    Douglas Yee; Fiscal Year: 2006
  8. p53 and pathways of apoptosis
    Donna L George; Fiscal Year: 2010
  9. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
  10. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003

Detail Information

Publications210 found, 100 shown here

  1. ncbi Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease
    G E Krassas
    Department of Endocrinology and Metabolism, Panagia General Hospital, 55132 Thessaloniki, Greece
    J Clin Endocrinol Metab 88:132-5. 2003
    ..The increased IGF levels in retrobulbar tissues previously described, appear to be independent of serum IGFs concentration and probably represent autocrine and/or paracrine activity...
  2. pmc Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:3095-109. 2007
    ..Here we show that p53 transcriptional activation leads to enhanced expression of hepatic IGFBP1 (insulin-like growth factor-binding protein-1)...
  3. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..We comprehensively examined the association between common genetic variation in the IGF1, IGFBP1, and IGFBP3 genes in relation to circulating IGF-I and IGFBP-3 levels and breast cancer risk within the NCI Breast ..
  4. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
    ..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer...
  5. ncbi Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes
    Pamela J Goodwin
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Breast Cancer Res Treat 74:65-76. 2002
    ..The adverse effect of IGFBP-3 on distant recurrence in postmenopausal women with estrogen receptor positive breast cancer should be further investigated...
  6. doi Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction
    Maria Koutsaki
    Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion, Crete, Greece
    Growth Horm IGF Res 21:31-6. 2011
    ..This study aimed to evaluate the expression of hPGH, IGF-I, IGFBP-1 and IGFBP-3 genes in placentas from pregnancies complicated by fetal growth restriction (FGR)...
  7. ncbi Reduced IGFBP-1 is associated with thickening of the carotid wall in type 2 diabetes
    Eeva S Leinonen
    Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Diabetes Care 25:1807-12. 2002
    ..The aim of the present study was to assess the role of the insulin-like growth factor (IGF) system and lipids in predicting the carotid intima-media thickness (IMT) in type 2 diabetes...
  8. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
    ..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis...
  9. ncbi Polymorphisms in IGF-binding protein 1 are associated with impaired renal function in type 2 diabetes
    Richard H Stephens
    Vascular Research Group, Hope Hospital, Salford, UK
    Diabetes 54:3547-53. 2005
    ..We genotyped 13 single nucleotide polymorphisms (SNPs) in IGFBP1 gene in 732 representative type 2 diabetic patients from the Salford Diabetes Register...
  10. doi Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age
    Danielle van der Kaay
    Department of Pediatrics, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:1386-92. 2009
    ..Data on IGFBP-1 levels in short, small for gestational age (SGA) subjects are scarce, and associations with IGFBP1 promoter single nucleotide polymorphisms have not been established.
  11. doi Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 164:715-23. 2011
    ..Controversy remains whether differences in the levels of IGF1 and its binding proteins 1 and 3 (IGFBP1 and IGFBP3) determine health outcomes during ageing...
  12. doi A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Francesca L Crowe
    Nuffield Department of Clinical Medicine, University of Oxford, UK
    Ann Hum Biol 38:194-202. 2011
    ..Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk...
  13. ncbi The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study
    Gail A Laughlin
    Department of Family and Preventive Medicine, University of California San Diego School of Medicine, La Jolla, California 92093 0607
    J Clin Endocrinol Metab 89:114-20. 2004
    ..We conclude that low baseline levels of IGF-I and IGFBP-1 increase the risk of fatal IHD among elderly men and women independent of prevalent IHD and CVD risk factors...
  14. pmc Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence
    J I Jones
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7170
    Proc Natl Acad Sci U S A 90:10553-7. 1993
    ..The effect of IGFBP-1 on migration is independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin...
  15. pmc Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
    F Canzian
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 94:299-307. 2006
    ..We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls...
  16. pmc Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carcinogenesis 30:2042-6. 2009
    ..We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-tagging single nucleotide ..
  17. doi Insulin-like growth factor-binding protein-1 in the prediction and development of type 2 diabetes in middle-aged Swedish men
    M S Lewitt
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, SE 171 76, Sweden
    Diabetologia 51:1135-45. 2008
    ..The aim of this study was to evaluate the predictive role and change in IGFBP-1 concentrations during development of abnormal glucose regulation...
  18. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  19. ncbi Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes
    Paul Smith
    The Breakthrough Toby Robins Breast Cancer Research Centre at The Institute of Cancer Research, Mary Jean Mitchell Green Building, Chester Beatty Laboratories, London, UK
    Clin Cancer Res 13:4061-8. 2007
    ..To analyze epigenetic regulation of two related genes, insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) and IGFBPL1, and its significance as a determinant of clinical phenotypes in human breast cancer...
  20. ncbi Endoplasmic reticulum stress induction of insulin-like growth factor-binding protein-1 involves ATF4
    Alexandre Marchand
    INSERM UMR S 747, Universite Paris Descartes, 45 Rue des Saints Peres, 75270 Paris, France
    J Biol Chem 281:19124-33. 2006
    ..Increased secretion of IGFBP-1 during hepatic ER stress may thus constitute a signal to modulate cell growth and metabolism and induce a systemic adaptive response...
  21. ncbi Insulin-like growth factor 2 (IGF2 ) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetologia 44:2231-6. 2001
    The aim of this study was to investigate the role of insulin-like growth factor 1 (IGF1), IGF2, IGF binding protein 1 (IGFBP1) and IGFBP3 gene variants on the metabolic changes observed in response to a 100-day overfeeding protocol ..
  22. doi Insulin-like growth factor binding protein-1 is a long-term predictor of heart failure in survivors of a first acute myocardial infarction and population controls
    Imre Janszky
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Int J Cardiol 138:50-5. 2010
    ..Only a few studies have investigated the prospective relationship between insulin-like growth factor binding protein-1 (IGFBP-1) and cardiovascular events and the results are conflicting...
  23. ncbi Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA, and Department of Medicine, Lady Davis Research Institute of Jewish General Hospital, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 92:1319-25. 2007
    ..Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults...
  24. doi Effect of the somatostatin analog octreotide acetate on circulating insulin-like growth factor-1 and related peptides in patients with non-metastatic castration-resistant prostate cancer: results of a phase II study
    Terence W Friedlander
    Urologic Oncology Program, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Urol Oncol 30:408-14. 2012
    ..In this study, the efficacy of depot octreotide acetate was prospectively evaluated in patients with CRPC...
  25. ncbi Insulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight
    Daniel K Tisi
    School of Dietetics and Human Nutrition, McGill University, Montreal, Canada
    J Nutr 135:1667-72. 2005
    ..0283 and 0.0404, respectively). These results show that 2nd trimester AF IGF BP1, BP3, and IGF II may emerge as early indicators of fetal growth...
  26. pmc High insulinlike growth factor binding protein 1 level predicts incident congestive heart failure in the elderly
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am Heart J 155:1006-12. 2008
    ..We investigated the association between fasting plasma levels of IGF-I, IGFBP-1, IGFBP-3, and insulin and risk of incident CHF in the prospective Cardiovascular Health Study...
  27. pmc Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor
    J J Kim
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 73:833-9. 2005
    Insulin-like growth factor-binding protein-1 (IGFBP1) is a major secretory product of the decidualized endometrium...
  28. ncbi Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy
    Daniela J Jakubowicz
    Hospital de Clinicas Caracas, and Central University of Venezuela, Caracas 1040, Venezuela
    J Clin Endocrinol Metab 89:833-9. 2004
    ..These decreases are likely to be secondary to hyperinsulinemia and reduced insulin sensitivity...
  29. doi Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease
    Kirstin Worthmann
    Department of Medicine Nephrology, Hannover Medical School, Carl Neuberg Street 1, Hannover, Germany
    Growth Factors 28:129-38. 2010
    ..We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS...
  30. doi IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia 6009, Australia
    Eur J Endocrinol 162:249-57. 2010
    ..The relationship between IGF-binding proteins 3 and 1 (IGFBP3 and IGFBP1) with risk of cardiovascular disease remains unclear...
  31. pmc TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways
    Nicole M Kane
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, Scotland, United Kingdom
    PLoS ONE 5:e12970. 2010
    ..A role for TGFβ1 in decidualization remains to be established and published data concerning effects of TGFβ1 on markers of endometrial decidualization are inconsistent...
  32. doi Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai Urban Rural Epidemiology Study 118)
    Kuppan Gokulakrishnan
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India
    Metabolism 61:43-6. 2012
    ..942; 95% confidence interval, 0.914-0.971; P < .001). Among Asian Indians, lower levels of circulating IGFBP-1 are seen in subjects with IR, T2DM, and MS...
  33. doi Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival
    S Ammoun
    Clinical Neurobiology, Peninsula College for Medicine and Dentistry, Plymouth, UK
    Oncogene 31:1710-22. 2012
    ..Thus, IGFBP-1/integrin β1/Src/FAK pathway has a crucial role in merlin-related tumourigenesis and therefore represents an important therapeutic target in the treatment of merlin-deficient tumours...
  34. doi The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation
    Jing Wang
    Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
    Atherosclerosis 220:102-9. 2012
    ....
  35. pmc Copeptin, IGFBP-1, and cardiovascular prognosis in patients with type 2 diabetes and acute myocardial infarction: a report from the DIGAMI 2 trial
    Linda G Mellbin
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 33:1604-6. 2010
    ..To determine whether C-terminal provasopressin (copeptin) explains the prognostic importance of insulin growth factor binding protein-1 (IGFBP-1) in patients with myocardial infarction and type 2 diabetes...
  36. ncbi Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1
    Ulrika Berg
    Department of Woman and Child Health, Pediatric Endocrinology and Diabetes Unit, Karolinska Institute, Astrid Lindgren Children s Hospital, S 171 76 Stockholm, Sweden
    Biol Chem 388:859-63. 2007
    ..Using the biosensor technique, in vitro binding of m-calpain to IGFBP-3 was demonstrated to be a Ca(2+)-dependent reaction with a rapid on/off rate...
  37. doi Sleeping during the day: effects on the 24-h patterns of IGF-binding protein 1, insulin, glucose, cortisol, and growth hormone
    Javaid ur Rehman
    Section for Psychology, Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Eur J Endocrinol 163:383-90. 2010
    ..We investigated how an acute shift of sleep to the daytime affected IGF-binding protein 1 (IGFBP1), which is a risk factor for diabetes.
  38. ncbi Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells
    T Kalme
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, FIN 00029 HUCH, Finland
    J Steroid Biochem Mol Biol 86:197-200. 2003
    ..We conclude that IGFBP-1 and SHBG are equally sensitive to ambient insulin concentrations in human hepatoma cell cultures, and the production of both proteins is also attenuated by the IGFs...
  39. ncbi Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101
    J I Jones
    Department of Medicine, University of North Carolina, Chapel Hill 27599
    J Biol Chem 268:1125-31. 1993
    ..We conclude that Ser101 represents the major site of phosphorylation containing 63% of the total 32P incorporated and that phosphorylation of Ser101 is important for maintenance of high affinity binding for this growth factor...
  40. doi Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms
    Lorenzo Dolcini
    Department of Biochemistry A Castellani, University of Pavia, Italy
    FEBS J 276:6033-46. 2009
    ....
  41. doi Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression
    M Alberstein
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    J Viral Hepat 19:65-71. 2012
    ....
  42. pmc Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation
    Julia I Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:1251-9. 2003
    ..These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways...
  43. ncbi Administration of human insulin-like growth factor-binding protein-1 increases circulating levels of growth hormone in mice
    Vesna Cingel-Ristic
    Laboratory of Pediatrics, Subdivision of Molecular Endocrinology, Erasmus Medical Center, 3000 DR Rotterdam, Rotterdam, The Netherlands
    Endocrinology 145:4401-7. 2004
    ..In conclusion, GH serum levels increased in response to hIGFBP-1 administration, even in the setting of normal IGF-I levels. This finding suggests a direct involvement of IGFBP-1 in GH secretion...
  44. ncbi The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells
    Donna Seto-Young
    Division of Endocrinology, Beth Israel Medical Center and Albert Einstein College of Medicine, New York, New York 10003, USA
    J Clin Endocrinol Metab 88:3385-91. 2003
    ....
  45. pmc IGF-1 and IGF-binding proteins and bone mass, geometry, and strength: relation to metabolic control in adolescent girls with type 1 diabetes
    Laurie J Moyer-Mileur
    Center for Pediatric Nutrition Research, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA
    J Bone Miner Res 23:1884-91. 2008
    ....
  46. ncbi Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3
    Y Dubaquie
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Biochemistry 38:6386-96. 1999
    ..The fact that the functional binding epitopes on IGF-I are overlapping but distinct for both binding proteins may be exploited to design binding protein-specific IGF variants...
  47. ncbi Insulin-like growth factor-binding protein-1 expression in cultured human bone cells: regulation by insulin and glucocorticoid
    C A Conover
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 137:3295-301. 1996
    ..Insulin acts through insulin receptors on hOB cells. We postulate that IGFBP-1 produced by osteoblasts in vivo can modulate local actions of IGF on bone formation in response to changes in glucocorticoid and insulin concentrations...
  48. ncbi Sequential appearance of relaxin, prolactin and IGFBP-1 during growth and differentiation of the human endometrium
    G D Bryant-Greenwood
    Department of Anatomy and Reproductive Biology, University of Hawaii, Honolulu 96822
    Mol Cell Endocrinol 95:23-9. 1993
    ..In contrast, all three proteins were immunostained in early pregnancy and increased to term gestation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  49. doi Common genetic variation of insulin-like growth factor-binding protein 1 (IGFBP-1), IGFBP-3, and acid labile subunit in relation to serum IGF-I levels and mammographic density
    Cornelia W Taverne
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, PO Box 85500, Utrecht, 3508, GA, The Netherlands
    Breast Cancer Res Treat 123:843-55. 2010
    ..women within the Prospect-EPIC cohort, we examined associations of 14 haplotype tagging SNPs in the ALS, IGFBP1, and IGFBP3 genes with IGF-I circulating levels and mammographic density...
  50. ncbi Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions
    S Rajaram
    Mineral Metabolism Laboratory, Jerry L Pettis Memorial Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocr Rev 18:801-31. 1997
  51. ncbi Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 144:3922-33. 2003
    ..Hence, elevations in circulating and tissue levels of IGFBP-1 may be an important mediator for the muscle catabolism observed in various stress conditions...
  52. ncbi Matrix metalloprotease-3 and -9 proteolyze insulin-like growth factor-binding protein-1
    Hedley A Coppock
    Endocrine Sciences, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK
    Biol Reprod 71:438-43. 2004
    ..These findings suggest cleavage of IGFBP-1 as a novel mechanism in the control of placental development by matrix metalloproteases...
  53. doi Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells
    Yu Ma
    Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China
    Exp Mol Pathol 85:141-5. 2008
    ..Restoration of IGFBP-rP1 function might have potential therapeutic significance in colorectal cancer...
  54. ncbi Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1
    Stephen B Wheatcroft
    Department of Cardiology, Guy s, King s and St Thomas School of Medicine, London, UK
    Diabetes 52:2075-82. 2003
    ..Our data suggest that IGFBP-1 plays an important and potentially beneficial role in regulating metabolic and vascular homeostasis...
  55. ncbi Insulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity, and leptin in healthy, glucose-tolerant young men
    Choon F Liew
    Department of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore
    J Clin Endocrinol Metab 90:1483-8. 2005
    ..The presence of relative insulin resistance and low fasting IGFBP-1 levels in Asian Indians may contribute to their higher risk of developing diabetes and cardiovascular disease...
  56. ncbi Insulin-like growth factor binding protein (IGFBP-1) involvement in intrauterine growth retardation: study on IGFBP-1 overexpressing transgenic mice
    Nadia Ben Lagha
    Laboratoire de Biologie Oro Faciale et Pathologie, Institut National de la Santé et de la Recherche Médicale Unité 714, Institut Biomedical des Cordeliers, 15 21 Rue de l Ecole de Médecine, 75006 Paris, France
    Endocrinology 147:4730-7. 2006
    ..Similar perturbations could be observed in human intrauterine growth retardation suggesting the IGF/IGFBP system is involved in fetal growth, biomineralization, and energetic status in humans...
  57. ncbi Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid
    Alberto Sala
    Department of Biochemistry A Castellani, University of Pavia, Italy
    J Biol Chem 280:29812-9. 2005
    ..Iron (II) decreases the binding of intact IGFBP-1 and the C-terminal domain to IGF-II, suggesting that the metal binding site is close to or part of the surface of interaction of the two molecules...
  58. ncbi Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort
    Iona Cheng
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006
    ..To examine whether inherited differences in the IGFBP1 and IGFBP3 genes influence prostate and breast cancer susceptibility, we conducted two large population-based ..
  59. pmc Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice
    Paul A Crossey
    Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    J Clin Invest 110:411-8. 2002
    ....
  60. ncbi The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors
    Tatjana Degenhardt
    Department of Biochemistry and A I Virtanen Institute, University of Kuopio, FIN 70211 Kuopio, Finland
    J Biol Chem 281:39607-19. 2006
    ..We also show that these additional PPAR binding genes contain a number of candidate PPREs and that their mRNA levels respond quickly to the presence of PPAR ligands, indicating that they are also primary PPAR target genes...
  61. ncbi Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs), -1, -2, -3, in oral cancer
    G Brady
    York Hospital, UK
    Int J Oral Maxillofac Surg 36:259-62. 2007
    ..Reported evidence suggests that cancer (non-oral) is associated with high circulating levels of IGF-1 and low levels of IGFBP-3...
  62. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  63. ncbi Insulin response sequence-dependent and -independent mechanisms mediate effects of insulin on glucocorticoid-stimulated insulin-like growth factor binding protein-1 promoter activity
    Lixia Gan
    Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, USA
    Endocrinology 146:4274-80. 2005
    ....
  64. ncbi Strong suppression of tumor growth by insulin-like growth factor-binding protein-related protein 1/tumor-derived cell adhesion factor/mac25
    Yuichiro Sato
    Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, 641 12 Maioka cho, Totsuka ku, Yokohama 244 0813, Japan
    Cancer Sci 98:1055-63. 2007
    ..Cell surface IGFBP-rP1 may reduce the anchorage-independent growth ability, leading to the marked loss of tumorigenicity...
  65. ncbi Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population
    Iona Cheng
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0794, USA
    J Clin Endocrinol Metab 92:3660-6. 2007
    ..Both circulating levels and genetic variation of IGFs have been associated with cancer risk, yet the relationship between the two is not well understood...
  66. ncbi Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction
    Carole S Watson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Endocrinology 147:1175-86. 2006
    ..5; P < 0.05). Thus, this model of FGR is associated with a larger placenta, but without postnatal catch-up growth. Overall, these data clearly demonstrate that high concentrations of circulating IGFBP-1 are sufficient to cause FGR...
  67. ncbi Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells
    J Julie Kim
    Department of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine and VA Chicago Healthcare System West Side, Chicago, Illinois 60612, USA
    Biol Reprod 68:24-30. 2003
    ..These studies show that FKHR and HOXA10 interact directly and can function cooperatively to stimulate IGFBP-1 promoter activity in endometrial cells and perhaps in other settings...
  68. ncbi Reproductive abnormalities in human IGF binding protein-1 transgenic female mice
    Pascal Froment
    Physiologie de la Reproduction et des Comportements, Unité Mixte de Recherche 6073 Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université F Rabelais de Tours, 37380 Nouzilly, France
    Endocrinology 143:1801-8. 2002
    ..Increased circulating IGFBP-1 concentrations may additionally lead to altered GnRH and LH pulsatility and thereby exacerbate the ovulation defect...
  69. ncbi Bone formation in the context of growth retardation induced by hIGFBP-1 overexpression in transgenic mice
    N Ben Lagha
    Laboratoire de Biologie Orofaciale et Pathologie, INSERM EMI U 0110, Universite Paris 7, IFR 58, Institut Biomedical des Cordeliers, Esc E, 2è ét, 15 21 Rue de l Ecole de Médecine, 75270 Paris, France
    Connect Tissue Res 43:515-9. 2002
    ..These data show the involvement of the IGF/IGFBP system and more particularly IGFBP-1 in the biomineralization process...
  70. ncbi Serum insulin-like growth factor type 1, insulin-like growth factor-binding protein-1, and insulin-like growth factor-binding protein-3 concentrations in patients with thyroid dysfunction
    P Iglesias
    Department of Endocrinology, Hospital General de Segovia, Madrid, Spain
    Thyroid 11:1043-8. 2001
    ..01). The results of the present study show that thyroid status affects GH/IGF axis. Hypothyroidism is associated with significant reductions of IGF-1 and IGFBP-3, and IGFBP-1 is elevated in both hypothyroidism and hyperthyroidism...
  71. ncbi The regional expression of insulin-like growth factor II (IGF-II) and insulin-like growth factor binding protein-1 (IGFBP-1) in the placentae of women with pre-eclampsia
    R J Gratton
    Department of Obstetrics and Gynecology, CIHR Group in Fetal and Neonatal Health and Development, The Child Health Research Institute, The Lawson Health Research Institute, The University of Western Ontario, London, Canada
    Placenta 23:303-10. 2002
    ..The altered IGF-II and IGFBP-1 expression at the fetomaternal interface may be important in the pathophysiology of pre-eclampsia...
  72. ncbi Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7
    E Ehrenborg
    Department of Clinical Genetics, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
    Genomics 12:497-502. 1992
    ..Further characterization of the IGBP1 DNA sequence disclosed a duplication of the intron 3-exon 4 junction within the third intron. In addition, we report RFLPs for ApaLI and TaqI in the IGBP1 locus...
  73. ncbi Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6
    J J Bond
    Cooperative Research Centre for Diagnostic Technologies, Brisbane, Queensland 4001, Australia
    J Endocrinol 165:253-60. 2000
    ..This may increase the tissue availability of serum pro-IGF-II, allowing its insulin-like potential to be realised...
  74. ncbi The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study
    Michael S Boyne
    Tropical Metabolism Research Unit, Tropical Medicine Research Institute, The University of the West Indies, Mona, Kingston 7, Jamaica
    J Clin Endocrinol Metab 88:1687-91. 2003
    ..In conclusion, maternal IGF-I levels, especially during late pregnancy, positively influence birth weight...
  75. ncbi Duplication of 7p12.1-p13, including GRB10 and IGFBP1, in a mother and daughter with features of Silver-Russell syndrome
    C A Joyce
    Wessex Regional Genetics Laboratory, Salisbury Health Care Trust, Wilts, UK
    Hum Genet 105:273-80. 1999
    ..growth-related genes GRB10 (growth factor receptor-bound protein 10), EGFR (epidermal growth factor receptor) and IGFBP1 (insulin-like growth factor binding protein 1), all of which have been suggested as candidate genes for SRS...
  76. ncbi Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency
    R M Popovici
    Department of Gynecology and Obstetrics, Stanford University Medical School, Stanford, California 94305, USA
    J Clin Endocrinol Metab 86:2653-9. 2001
    ..The data support a role for the fetal liver as a source of elevated circulating levels of IGFBP-1 in fetuses with in utero hypoxia and IUGR...
  77. ncbi The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry
    G M Neumann
    Department of Biochemistry, LaTrobe University, Bundoora, Victoria 3083, Australia
    J Biol Chem 274:14587-94. 1999
    ..The N-terminal linkages of IGFBP-6 differ significantly from those of IGFBP-1 (and, by implication, the other IGFBPs), which could contribute to the distinctive IGF binding properties of IGFBP-6...
  78. ncbi Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival
    Tung H Ngo
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    Endocrinology 144:2319-24. 2003
    ..DE results in a decrease in serum IGF-I with increased IGFBP-1 in vivo that is associated with apoptosis and reduced LNCaP and LAPC-4 prostate cancer cell growth in vitro...
  79. ncbi Reproductive abnormalities in human insulin-like growth factor-binding protein-1 transgenic male mice
    Pascal Froment
    Physiologie de la Reproduction et des Comportements, Unité Mixte de Recherche 6073, Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université F Rabelais de Tours, 37380 Nouzilly, France
    Endocrinology 145:2080-91. 2004
    ..Our observations are consistent with the idea that normal spermatogenesis and perhaps also steroidogenesis are dependent on the actions of sufficient concentrations of unbound IGF-I...
  80. ncbi Metabolic, anthropometric, and nutritional factors as predictors of circulating insulin-like growth factor binding protein-1 levels in middle-aged and elderly men
    Katarina Wolk
    Department of Medicine, Karolinska Institutet, SE 17177 Stockholm
    J Clin Endocrinol Metab 89:1879-84. 2004
    ..Our data suggest that metabolic, anthropometric, and nutritional factors are important determinants of IGFBP-1 levels in healthy men...
  81. ncbi Insulin-like growth factor (IGF)-1 and IGF binding protein-1 and -3 in the follicular fluid of infertile patients with endometriosis
    J S L Cunha-Filho
    Obstetrics and Gynecology Department, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil
    Hum Reprod 18:423-8. 2003
    ..The objective of this present paper was to analyse the dosages of insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 and 3 (IGFBP-1 and IGFBP-3) in the follicular fluid environment of infertile patients with endometriosis...
  82. ncbi Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli
    G B Godbole
    National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Street, Parel, Mumbai 400012, India
    Reproduction 134:513-23. 2007
    ..In addition, the mRNA expression of HOXA11 and insulin-like growth factor-binding protein 1 (IGFBP1) was evaluated by real-time PCR in these animals...
  83. ncbi Effects of insulin-like growth factors (IGF) on pancreatic islet function in IGF binding protein-1 transgenic mice
    S T Dheen
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Diabetologia 39:1249-54. 1996
    ..Rather, the data suggest that the hyperglycaemia or local effects of IGFBP-1 over-expression results in a state of enhanced insulin secretion which persists under short-term in vitro culture conditions...
  84. pmc Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium
    Banghyun Lee
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 80:79-85. 2009
    ..Insulin-like growth factor binding protein-1 (Igfbp1) mRNA was decreased in the endometriosis group...
  85. ncbi Body composition and circulating levels of insulin, insulin-like growth factor-binding protein-1 and growth hormone (GH)-binding protein affect the pharmacokinetics of GH in adults independently of age
    Troels Krarup Hansen
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 87:2185-93. 2002
    ....
  86. ncbi Inhibition of matrix metalloproteinases prevents the synthesis of insulin-like growth factor binding protein-1 during decidualization in the baboon
    Zuzana Strakova
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612 7313, USA
    Endocrinology 144:5339-46. 2003
    ..Disruption of actin filaments enhances IGFBP-1 induction. Thus, our data imply that IL-1beta-induced MMPs and particularly MMP-3 may up-regulate IGFBP-1 by disrupting the actin cytoskeleton as a result of ECM degradation...
  87. ncbi C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:750-5. 2006
    ..However, few studies have evaluated whether these factors are also associated with risk of colorectal adenoma, the main precursor lesion to colorectal cancer...
  88. doi dlk1 specifically interacts with insulin-like growth factor binding protein 1 to modulate adipogenesis of 3T3-L1 cells
    Maria Luisa Nueda
    Department of Inorganic and Organic Chemistry and Biochemistry, Medical School, Regional Center for Biomedical Research, University of Castilla La Mancha, Avenida de Almansa 14, 02006 Albacete, Spain
    J Mol Biol 379:428-42. 2008
    ..strong and specific interaction between the protease-target dlk1 region and the non-IGF binding region of IGF binding protein 1 (IGFBP1), a protein that binds to IGFs and modulates their action...
  89. pmc Omeprazole stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation
    Iain A Murray
    Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, 309A Life Sciences Bldg, The Pennsylvania State University, University Park, PA 16802, USA
    J Pharmacol Exp Ther 324:1102-10. 2008
    ..These data demonstrate that activation of hAhR by pharmaceuticals such as omeprazole can alter IGFBP-1 expression and thus may influence IGFBP-1-dependent physiological processes...
  90. ncbi Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors
    Isabelle Foucher
    CNRS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 129:4065-74. 2002
    ..present a liver phenotype illustrated by a 12-fold increase in liver insulin-like growth factor binding protein 1 (IGFBP1) mRNA and a 50% decrease in liver insulin-like growth factor 1 (IGF1) mRNA correlated with a 50% decrease in ..
  91. doi Polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) potentiates IGF-I actions in placenta
    Hiromi Shibuya
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Tokyo, Japan
    J Cell Physiol 226:434-9. 2011
    ..These results suggest that progesterone might facilitate polymerization of decidua-secreted IGFBP-1 and increase IGF-I actions at feto-maternal interface, thereby stimulating trophoblast invasion of maternal uterus...
  92. ncbi Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women
    S Soderberg
    Department of Medicine, Umea University Hospital, Sweden
    Eur J Endocrinol 144:283-90. 2001
    ..We therefore examined the relationship between leptin, IGF-I, IGFBP-1, insulin and proinsulin in men and women with or without obesity in a population study...
  93. doi Serum glucocorticoids and adiponectin associate with insulin resistance in children born small for gestational age
    S Tenhola
    Department of Pediatrics, University of Kuopio and Kuopio University Hospital, PO Box 1777, FI 70211 Kuopio, Finland
    Eur J Endocrinol 162:551-7. 2010
    ..We aimed to investigate whether serum glucocorticoid parameters are related to IR in children born small for gestational age (SGA)...
  94. ncbi A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:850-5. 2005
    ..Although altering IGF-I levels may not be practical, the growing burden of obesity and consequently hyperinsulinemia, which seems increasingly important for colon cancer, may be a target for effective prevention...
  95. ncbi Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
    Leszek Pawelczyk
    Department of Gynecology and Obstetrics, Karol Marcinkowski University of Medical Sciences, ul Polna 33, 60 535 Poznan, Poland
    Eur J Obstet Gynecol Reprod Biol 113:209-13. 2004
    ..and increased levels of free insulin-like growth factor-I (IGF-I), presumably due to a decline in IGF binding protein 1 (IGFBP-1)...
  96. ncbi Systemic and renal growth hormone-IGF1 axis involvement in a mouse model of type 2 diabetes
    Y Segev
    Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Diabetologia 50:1327-34. 2007
    ..We therefore examined the endocrine and renal GH-IGF axis changes in db/db mice, a model of type 2 diabetes mellitus and nephropathy...
  97. doi Insulin-like growth factor binding protein-1 activates integrin-mediated intracellular signaling and migration in oligodendrocytes
    Daniel Chesik
    Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    J Neurochem 113:1319-30. 2010
    ..Our results suggest that up-regulation of IGFBP-1 in oligodendrocytes in MS may serve two functions: (i) regulate IGF-1 actions, (ii) exert IGF-independent effects through its RGD sequence...
  98. pmc Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA
    Am J Pathol 172:916-25. 2008
    ..growth factor (HGF), insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 1 (IGFBP1), metallothionein (MT), and cyclin D1, as well as HNF-4alpha...
  99. pmc Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 385:639-48. 2005
    ..Furthermore, three other insulin-controlled genes, namely IGFBP1 (insulin-like-growth-factor-binding protein-1), IRS2 (insulin receptor substrate 2) and glucokinase, were ..
  100. ncbi Phospholipase D1 as a key enzyme for decidualization in human endometrial stromal cells
    Mee Sup Yoon
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, Korea
    Biol Reprod 76:250-8. 2007
    ..morphology and produced significant amounts of prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). Simultaneously, the activity and expression levels of PLD1 increased...
  101. doi Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation
    Rebecca M Simmons
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Endocrinology 150:4295-305. 2009
    ..in the ovine and bovine uterus; effects of P4 and IFNT on their expression in the ovine uterus; and effects of IGFBP1 on ovine trophectoderm cell proliferation, migration, and attachment...

Research Grants68

  1. MOLECULAR REGULATION OF IGF BINDING PROTEIN 1
    Terry Unterman; Fiscal Year: 1999
    ..The results of these studies should provide insight into specific mechanisms by which glucocorticoids and insulin interact to regulate hepatic gene expression and modulate biological effects of IGFs in disorders of metabolism. ..
  2. REVERSAL OF DECLINE OF GH SECRETION OF AGING
    Michael Thorner; Fiscal Year: 2002
    ..adults with increased visceral fat, administration of metformin, a biguanide, for 4 weeks will lower insulin levels without changing blood glucose, will increase circulating IGFBP1 levels and thus enhance GH secretion in older adults.
  3. Obesity and Diabetes Familial Risk in Hispanic Children
    Nancy F Butte; Fiscal Year: 2010
    ..In this project, we propose to identify variants in genes that influence fasting glucose, insulin, ghrelin and IGFBP1 in Hispanic children...
  4. MOLECULAR REGULATION OF IGF BINDING PROTEIN 1
    Terry Unterman; Fiscal Year: 2003
    ..Hence, IGFBP1 provides an important model for understanding evolutionarily conserved mechanisms mediating effects of insulin-..
  5. Modulators of liver injury
    JULIE I JU LEU; Fiscal Year: 2007
    ..to play a role during liver repair and regeneration is the Insulin-like Growth Factor Binding Protein-1 (IGFBP1)...
  6. p53 and pathways of apoptosis
    DONNA GEORGE; Fiscal Year: 2007
    ..discovery of a functional link between a liver survival factor, insulin-like growth factor binding protein 1 (IGFBP1), and the p53 protein...
  7. Treatment of Breast Cancer with IGFBP1
    Douglas Yee; Fiscal Year: 2006
    ..Our long-term goal is to prove that the IGFs are key targets for the treatment of breast cancer. By optimizing IGF neutralization strategies, we will be prepared to move this anti-IGF strategy into the clinic. ..
  8. p53 and pathways of apoptosis
    Donna L George; Fiscal Year: 2010
    ..discovery of a functional link between a liver survival factor, insulin-like growth factor binding protein 1 (IGFBP1), and the p53 protein...
  9. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..Serum samples will be assayed for insulin, IGF-1, IGFBP1, and IGFBP3 levels for all cohort members at both the time of colonoscopy, as well as at the time of two earlier ..
  10. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..Serum samples will be assayed for insulin, IGF-1, IGFBP1, and IGFBP3 levels for all cohort members at both the time of colonoscopy, as well as at the time of two earlier ..
  11. Gender differences in Bone Loss and Incident Fractures
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..Recently completed assays performed on blood obtained at earlier visits include IGF-1, IGFBP1, IL-6, C-reactive protein, PTH and 25 OH and 1,25 (OH)2 vitamin D...
  12. CENTER FOR DIGESTIVE AND LIVER DISEASES
    Anil Rustgi; Fiscal Year: 2007
    ..culture model of Barrett's esophagus; (3) Hematopoietic contribution to the gut vasculature; and (4) A p53/IGFBP1 regulatory circuit and liver cancer...
  13. Obesity and Diabetes Familial Risk in Hispanic Children
    Nancy Butte; Fiscal Year: 2009
    ..In this project, we propose to identify variants in genes that influence fasting glucose, insulin, ghrelin and IGFBP1 in Hispanic children...
  14. Postprandial glycemic response to 4-week low and high glycemic load diets
    Marian Neuhouser; Fiscal Year: 2007
    ..eight hours of serial blood draws to assess the protracted postprandial response of insulin, glucose, IGFI, IGFII, IGFBP1, IGFBP3, free fatty acids, and triglycerides...
  15. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2003
    ..abstract_text> ..
  16. TARGETING THE IGF SYSTEM IN BREAST CANCER
    Douglas Yee; Fiscal Year: 2002
    ..The IGF system appears to be at least equally important in stimulating breast cancer growth, and demonstrating targetable points in its functional pathway could well have an equally valuable impact on overall breast cancer treatment. ..