IGFBP-3

Summary

Gene Symbol: IGFBP-3
Description: insulin-like growth factor binding protein 3
Alias: BP-53, IBP3, IBP-3, IGF-binding protein 3, IGFBP-3, acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, insulin-like growth factor-binding protein 3
Species: human

Top Publications

  1. pmc Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury
    Jennifer L Kielczewski
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610 0267, USA
    Am J Pathol 178:1517-28. 2011
  2. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
  3. doi Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-κB signaling
    Jinfeng Han
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298 0662, USA
    Cancer Lett 307:200-10. 2011
  4. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
  5. doi Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility
    Petra Massoner
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Endocr Relat Cancer 16:795-808. 2009
  6. ncbi Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases
    T L Gibson
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Growth Horm IGF Res 9:241-53. 1999
  7. doi IGFBP3 polymorphisms and risk of cancer: a meta-analysis
    Li Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Mol Biol Rep 37:127-40. 2010
  8. ncbi Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
  9. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
  10. pmc Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases
    Yong Chul Lee
    Department of Internal Medicine, School of Medicine, Chonbuk National University, Jeonju 56 182, South Korea
    J Biol Chem 286:17898-909. 2011

Research Grants

  1. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  2. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2007
  3. Insulin and IGF In female colon, breast, uterine cancer
    Howard Strickler; Fiscal Year: 2005
  4. Targeting the IGF-1 System in Retinal Angiogenesis
    Maria Grant; Fiscal Year: 2003
  5. Targeting the IGF-1 System in Retinal Angiogenesis
    Maria Grant; Fiscal Year: 2006
  6. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
  7. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2007
  8. IGF-I LEVELS, IGF-I GENOTYPE, AND PROSTATE CANCER
    Noel Weiss; Fiscal Year: 2002
  9. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
  10. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003

Detail Information

Publications198 found, 100 shown here

  1. pmc Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury
    Jennifer L Kielczewski
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610 0267, USA
    Am J Pathol 178:1517-28. 2011
    ....
  2. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  3. doi Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-κB signaling
    Jinfeng Han
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298 0662, USA
    Cancer Lett 307:200-10. 2011
    ..The use of IGFBP-3 as a cancer therapeutic with this distinctive suppression mechanism may offer alternate means to treat chemotherapy resistant tumors...
  4. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
    ..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer...
  5. doi Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility
    Petra Massoner
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Endocr Relat Cancer 16:795-808. 2009
    ..These newly described mechanisms of IGFBP-3 can be of importance for tumor progression and support a role of IGFBP-3 in therapeutic settings...
  6. ncbi Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases
    T L Gibson
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Growth Horm IGF Res 9:241-53. 1999
    ....
  7. doi IGFBP3 polymorphisms and risk of cancer: a meta-analysis
    Li Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Mol Biol Rep 37:127-40. 2010
    ..Further large study combining both IGFBP3 A-202C and Gly32Ala SNPs on different types of cancer in different populations were needed to validate former results...
  8. ncbi Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
    ..01). The current study provides some support for a role of IGFs in colorectal cancer etiology, particularly in mediating the relationship of common risk factors (physical activity, BMI, and postmenopausal hormone use)...
  9. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
    ..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis...
  10. pmc Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases
    Yong Chul Lee
    Department of Internal Medicine, School of Medicine, Chonbuk National University, Jeonju 56 182, South Korea
    J Biol Chem 286:17898-909. 2011
    ..The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease...
  11. ncbi Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer
    Lizhong Wang
    Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Cancer Res 63:4407-11. 2003
    ..Because of the significant differences in incidence of clinically evident PCa according to racial backgrounds, the conjecture should be further examined in different racial populations...
  12. ncbi Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators
    C Deal
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    J Clin Endocrinol Metab 86:1274-80. 2001
    ..The IGFBP3 promoter region deserves investigation as a locus where polymorphic variation occurs frequently and may influence GH responsiveness, somatic growth, and possibly cancer risk...
  13. ncbi Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo
    Hae Soon Kim
    Department of Pediatrics, Ewha Womans University, Seoul, 120 750 Korea
    Pediatr Res 61:159-64. 2007
    ....
  14. pmc Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
    F Canzian
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 94:299-307. 2006
    ..Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians...
  15. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  16. pmc Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carcinogenesis 30:2042-6. 2009
    ..Of particular interest was the IGFBP3 SNP rs2270628, which was associated with both increased IGF1 plasma levels and higher ovarian cancer risk...
  17. ncbi Differential regulation of IGFBP-3 by the androgen receptor in the lineage-related androgen-dependent LNCaP and androgen-independent C4-2 prostate cancer models
    Satoko Kojima
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 66:971-86. 2006
    ..Despite evidence implicating insulin-like growth factor binding protein-3 (IGFBP-3) as a growth inhibitor of prostate cancer (CaP), little is known about changes in its regulation and function during progression to androgen independence...
  18. ncbi Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA, and Department of Medicine, Lady Davis Research Institute of Jewish General Hospital, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 92:1319-25. 2007
    ..Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults...
  19. doi Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells
    Lujia Gribben
    Hormones and Cancer Division, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Cancer Lett 317:41-8. 2012
    ..This study demonstrates that endogenous IGFBP-3 modulates adhesion-migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease...
  20. doi Circulating insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 levels and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort
    Catherine Schairer
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, 20852 7244, USA
    Horm Cancer 1:100-11. 2010
    ..Further research should emphasize larger studies, including pooled analyses, analyses by cancer subtype, improved exposure assessment, and possible mechanisms...
  21. ncbi Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
    ....
  22. ncbi Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Detect Prev 31:408-16. 2007
    ..We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC...
  23. doi Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk
    Elisabeth Feik
    Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria
    Cancer Causes Control 21:91-7. 2010
    ..The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer...
  24. doi Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population
    Hao Xiang
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Toxicol Environ Health A 72:706-11. 2009
    ..Data suggest that the exon 1 G2133C missense variant of IGFBP3 may be a susceptibility factor for colorectal cancer in Chinese subjects. Larger studies are warranted to validate our findings in a Chinese population...
  25. ncbi Functional cloning of IGFBP-3 from human microvascular endothelial cells reveals its novel role in promoting proliferation of primitive CD34+CD38- hematopoietic cells in vitro
    Li qin Liu
    ViaCell Inc, Worcester, MA 01605, USA
    Oncol Res 13:359-71. 2003
    ....
  26. pmc IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women
    Aimee A D'Aloisio
    Epidemiology Branch, National Institute of Environmental Health Sciences, P O Box 12233, Mail Drop A3 05, Research Triangle Park, NC 27709, USA
    Cancer Epidemiol Biomarkers Prev 18:954-66. 2009
    ..Our study supports that common IGFBP-3 SNPs, especially rs2854746, influence plasma IGFBP-3 levels among African Americans and Caucasians but provides less evidence that IGF-I SNPs affect plasma IGF-I levels...
  27. pmc Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 30:1479-84. 2010
    ..The metabolic and genetic correlates of circulating insulin-like growth factor-1 (IGF-1) and its main circulating carrier, IGF-1-binding-protein-3 (IGFBP-3), are unclear...
  28. ncbi Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action
    S Mohseni-Zadeh
    Institut National de la Sante et de la Recherche Medicale, U 142, Hopital Saint Antoine, Paris, France
    Endocrinology 138:5645-8. 1997
    ..The present results provide the first evidence that IGFBP-3 may inhibit IGF binding to IGFR-1, and hence limit IGF action via a cellular mechanism that is different from the extracellular mechanism of sequestration...
  29. ncbi IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer
    Ali Al-Zahrani
    CR UK Department of Oncology, Cambridge, UK
    Hum Mol Genet 15:1-10. 2006
    ..More specifically and consistent with experimental models, our data suggest that higher IGF1 levels may increase the risk of breast cancer but higher IGFBP3 levels may be protective...
  30. ncbi Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB
    A C Williams
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, Bristol, UK
    Cell Death Differ 14:137-45. 2007
    ..We propose that IGFBP-3 is a non-toxic NF-kappaB inhibitor, which could be used as an adjuvant in the treatment of colon cancer...
  31. ncbi Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China
    Stephanie J London
    Epidemiology Branch and Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 94:749-54. 2002
    ..In a prospective study of men in Shanghai, China, we examined the association between serum levels of IGF-I and IGFBP-3 and the subsequent risk of lung cancer...
  32. ncbi Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:469-76. 2004
    ..Suppression of IGFBP-3 internalization by TfR1 blockade inhibited IGFBP-3-induced apoptosis. Together, these data indicate that the actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways...
  33. ncbi Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells
    Jiang Hong
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:10489-97. 2002
    ..These results indicate that IGF-independent mechanisms are major contributors to IGFBP-3-induced apoptosis in PC-3 cells and may play a wider role in the antiproliferative and antitumorigenic actions of IGFBP-3...
  34. ncbi Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 62:3530-7. 2002
    ....
  35. ncbi Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change
    Irena Kirman
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Surgery 132:186-92. 2002
    ..This study assessed the effect of plasma from patients who underwent major open (OS) or laparoscopic surgery (LS) on in vitro tumor cell growth...
  36. ncbi Evidence implicating a mid-region sequence of IGFBP-3 in its specific IGF-independent actions
    A D Hollowood
    University Department of Surgery, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom
    J Cell Biochem 86:583-9. 2002
    ....
  37. ncbi IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans
    Wenndy Hernandez
    Cancer Biology Program, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
    Carcinogenesis 28:2154-9. 2007
    ..Our study adds clarity and further support to the previous findings, implicating serum IGFBP-3 levels and the IGFBP-3 -202 A/C SNP in prostate carcinogenesis...
  38. ncbi Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, MA 02142, USA
    Hum Genet 122:129-39. 2007
    ....
  39. ncbi Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma
    P L Torng
    Department of Obstetric and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Oncogene 27:2137-47. 2008
    ..Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC...
  40. ncbi IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men
    Joellen M Schildkraut
    Program of Cancer Prevention, Detection and Control Research, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Cancer Epidemiol Biomarkers Prev 14:403-8. 2005
    ..Further research is needed to confirm these findings...
  41. doi Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients
    M Corbo
    Department of Neurology and Lab Neuroscience, Dino Ferrari Center, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Eur J Neurol 17:398-404. 2010
    ..In this context, little information is available on free IGF-1, the bioactive form of IGF-1, in amyotrophic lateral sclerosis (ALS)...
  42. ncbi Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo
    Gayathri R Devi
    Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    Prostate 51:141-52. 2002
    ..Insulin-like growth factor binding protein (IGFBP-3) levels are significantly reduced in malignant prostate epithelial cells. In this study, we evaluated the role of endogenous IGFBP-3 on prostate cancer cell growth and tumorigenesis...
  43. ncbi Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 13:1206-14. 2004
    ..We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway...
  44. ncbi Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma
    P Cohen
    Department of Pediatrics, Stanford University Medical Center, California 94305
    J Clin Endocrinol Metab 75:1046-53. 1992
    ..We speculate that PSA may serve to modulate IGF function within the reproductive system or in prostate cancer by altering IGF-IGFBP-3 interactions...
  45. ncbi cDNA microarray analysis with amplified RNA after isolation of intact cellular RNA from neoplastic and non-neoplastic prostate tissue separated by laser microdissections
    Paul Thelen
    Department of Urology, Georg August Universitat, D 37075 Gottingen, Germany
    Int J Oncol 24:1085-92. 2004
    ..Taken together, we present a novel method for the isolation of intact RNA from laser microdissection-derived prostate cancer tissue useful for downstream applications of real-time RT-PCR and cDNA microarrays...
  46. ncbi Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions
    S Rajaram
    Mineral Metabolism Laboratory, Jerry L Pettis Memorial Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocr Rev 18:801-31. 1997
  47. ncbi Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling
    Alison J Butt
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:1950-6. 2004
    ....
  48. ncbi Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 107:60-4. 2003
    ..Our data do not demonstrate a significant influence of this locus on breast cancer risk, but we cannot exclude a minor influence or an influence confined to subgroups...
  49. doi Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels
    Caroline Diorio
    Breast Cancer Functional Genomics Group and McGill Centre for Bioinformatics, McGill University, Montreal, QC, Canada
    Cancer Epidemiol Biomarkers Prev 17:880-8. 2008
    ....
  50. ncbi Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women
    Zefang Ren
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 13:1290-5. 2004
    ..05). These results indicated that IGFBP3 polymorphisms may be associated with the level of blood IGFBP-3 protein and an increased risk of breast cancer...
  51. ncbi Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Oncogene 23:6569-80. 2004
    ..Thus interference with Sp-1 transactivation by MeCP2 may contribute to the transcriptional defect of IGFBP-3 expression in NSCLC cells with methylated promoter...
  52. ncbi A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density
    Joe H Lai
    Centre for Research in Women s Health, University of Toronto, 8790 Bay Street, Toronto, Ontario, M5G 1N8 Canada
    Cancer Epidemiol Biomarkers Prev 13:573-82. 2004
    ..A high circulating level of insulin-like growth factor-I (IGF-I) and low IGF binding protein 3 (IGFBP-3) level have been associated with increased breast density in premenopausal women...
  53. pmc IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neoplasia 9:1091-8. 2007
    ..Our data suggest complex relationship between global genomic/epigenomic phenomena (such as MSI/CIMP), single molecular events (e.g., IGFBP3 methylation, TP53 mutation, and TGFBR2 mutation), and the related pathways...
  54. doi Serum insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, leptin concentrations and insulin resistance in benign and malignant epithelial ovarian tumors in postmenopausal women
    Ibrahim Serdar Serin
    Department of Obstetrics and Gynecology, Erciyes University Medical Faculty, Kayseri, Turkey
    Gynecol Endocrinol 24:117-21. 2008
    ....
  55. pmc Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome
    Sarah B Vestey
    University of Bristol, Department of Clinical Sciences at South Bristol Surgery, Bristol Royal Infirmary, Bristol, UK
    Breast Cancer Res 7:R119-29. 2005
    ....
  56. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  57. ncbi Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States
    M L Slattery
    University of Utah, Salt Lake City, Utah 84108, USA
    Breast Cancer Res Treat 104:197-209. 2007
    ..An insulin-related pathway to breast cancer has been hypothesized...
  58. ncbi Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study
    Sandra L Deming
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Breast Cancer Res Treat 104:309-19. 2007
    ..9) for the N/A-A/A genotypes (rs6413441). Taken together, these data suggest that polymorphisms in the IGF-1R and IGFBP3 genes may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status...
  59. ncbi Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis
    Frédéric R Santer
    Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria
    Cancer Res 66:3024-33. 2006
    ..Moreover, we show that IGFBP-3, if ectopically expressed in the nucleus, can induce apoptotic cell death. These results suggest that ubiquitin/proteasome-mediated proteolysis of IGFBP-3 may contribute to down-regulation of apoptosis...
  60. ncbi Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers
    Kunitoshi Tomii
    Department of Cancer and Thoracic Surgery, Shikata Laboratory, Advanced Science Research Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Int J Cancer 120:566-73. 2007
    ..079). In summary, our results showed that IGFBP-3 methylation played an important role in the silencing of its expression, suggesting that IGFBP-3 may act as a tumor suppressor gene in several human cancers examined...
  61. ncbi Differential expression of IGF-binding protein-3 in normal and malignant colon and its influence on apoptosis
    P J Jenkins
    Department of Endocrinology, William Harvey Research Institute, Barts and the London Queen Mary s School of Dentistry, John Vane Building, Charterhouse Square, UK
    Endocr Relat Cancer 12:891-901. 2005
    ..These effects are mediated in part by the PI-3K pathway in contrast to the MAP kinase pathway used by IGF-I...
  62. ncbi Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort
    Iona Cheng
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006
    ..Our results suggest that common genetic variation in the IGFBP1 and IGFBP3 genes do not substantially influence prostate and breast cancer susceptibility...
  63. ncbi Genetic, anthropometric, and lifestyle factors associated with IGF-1 and IGFBP-3 levels in Hispanic and non-Hispanic white women
    M L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Cancer Causes Control 16:1147-57. 2005
    ..These differences could be due to the combined effects of genetic and behavioral factors which could account for ethnic differences in the risk of breast cancer and other chronic diseases...
  64. ncbi CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3
    S Y Chun
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0682, USA
    Oncogene 26:4725-9. 2007
    ..These data demonstrate for the first time that (1) CDX2 can function as a transcriptional repressor, and (2) one mechanism by which CDX2 promotes anchorage-independent growth is by transcriptional repression of IGFBP-3...
  65. ncbi Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer
    Kerstin Wagner
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res Treat 92:133-40. 2005
    ..The interaction between the IGF-1 and its receptor is mainly regulated by a binding protein, IGFBP 3. We studied a CA repeat polymorphism 969 bp upstream of the transcription start site in the IGF-1 gene and an A-..
  66. ncbi Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus
    Nisan Bhattacharyya
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:24588-601. 2006
    ..These results indicate that IGFBP-3 can induce apoptosis in an IGF-independent manner without being secreted or concentrated in the nucleus...
  67. ncbi Insulin-like growth factor binding protein 3 in inflammatory bowel disease
    Irena Kirman
    Department of Surgery, Columbia University, New York, New York, USA
    Dig Dis Sci 50:780-4. 2005
    ..The level of intact IGFBP-3 is decreased in IBD patients with moderate to severe disease activity. This decrease may be linked to altered IGFBP-3 production or to increased cleavage by proteases other than MMP-9...
  68. ncbi p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia
    Adda Grimberg
    Division of Pediatric Endocrinology, The Children s Hospital of Philadelphia, Abramson Research Center, Room 802, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 4318, USA
    J Clin Endocrinol Metab 90:3568-74. 2005
    ..Because IGFBP-3 can inhibit growth and induce apoptosis in IGF-dependent and IGF-independent manners, its induction by DNA damage and hypoxia suggest IGFBP-3 plays a role in the physiologic protection against aberrant cell growth...
  69. ncbi Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2-19. 2005
    ..Further large studies, or combined analysis of data from existing studies, are needed to quantify these effects more precisely...
  70. ncbi Gender differences in the insulin-like growth factor axis response to a glucose load
    D E Flanagan
    Department of Endocrinology, Peninsula Medical School, Derriford Hospital, Plymouth, UK
    Acta Physiol (Oxf) 187:371-8. 2006
    ..The aim of our study was to examine the response of the IGFs and their binding proteins to an intravenous load of glucose in a cohort of young men and women with normal glucose tolerance...
  71. ncbi Role of insulin-like growth factor binding protein-3 in breast cancer cell growth
    Lynette J Schedlich
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Microsc Res Tech 59:12-22. 2002
    ..It may also act directly in the nucleus by enhancing the activity of retinoid X receptor-alpha and thereby promote apoptosis. All of the above phenomena will be discussed with particular emphasis on the growth of breast cancer cells...
  72. ncbi The amino-terminal region of insulin-like growth factor binding protein-3, (1-95)IGFBP-3, induces apoptosis of MCF-7 breast carcinoma cells
    Laurence Bernard
    Institut National de la Sante et de la Recherche Medicale, Unité 515, Croissance, Differenciation et Processus Tumoraux, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, Paris, France
    Biochem Biophys Res Commun 293:55-60. 2002
    ..These results provide further evidence that the N-terminal proteolytic fragment of IGFBP-3 has a functional role...
  73. ncbi Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis
    B Liu
    Department of Pediatrics, University of California, Los Angeles, California 90095 1752, USA
    J Biol Chem 275:33607-13. 2000
    ..IGFBP-3 enhanced RXR response element and inhibited RARE signaling. Thus, RXR-alpha-IGFBP-3 interaction leads to modulation of the transcriptional activity of RXR-alpha and is essential for mediating the effects of IGFBP-3 on apoptosis...
  74. ncbi Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma
    Y Gui
    Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
    J Clin Endocrinol Metab 86:2104-10. 2001
    ..These data indicate that FN may have a role in the transportation of IGFBP-3 and IGF-I in the circulation and the sequestration of these proteins in tissues...
  75. ncbi Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:3669-75. 2002
    ..Hypermethylation of the promoter represses the expression of the IGFBP-3 gene. The purpose of this study was to determine whether the methylation status of IGFBP-3 promoter influences the prognosis of non-small cell lung cancer (NSCLC)...
  76. ncbi Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis
    Polyxenie E Spoerri
    Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267, Gainesville, FL 32610 0267, USA
    Invest Ophthalmol Vis Sci 44:365-9. 2003
    ....
  77. ncbi Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma
    Tadashi Hanafusa
    Isotope Center, Okayama University, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Cancer Lett 176:149-58. 2002
    ..As IGFBP-3 functions like a tumor suppressor gene, it may be used as a therapeutic target for HCC...
  78. ncbi Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit
    L J Schedlich
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    J Biol Chem 275:23462-70. 2000
    ..Together these results suggest that the NLSs within the C-terminal domain of IGFBP-3 and IGFBP-5 are required for importin-beta-dependent nuclear uptake and probably also accumulation through mediating binding to nuclear components...
  79. ncbi Induction of the growth inhibitor IGF-binding protein 3 by p53
    L Buckbinder
    Department of Molecular Genetics, Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, New Jersey 08543 4000, USA
    Nature 377:646-9. 1995
    ..Our results indicate that IGF-BP3 may link p53 to potential novel autocrine/paracrine signalling pathways and to processes regulated by or dependent on IGF(s), such as cellular growth, transformation and survival...
  80. ncbi Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women
    H Jernstrom
    Centre for Research in Women s Health, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 10:377-84. 2001
    ..Our results support the view that circulating IGF-I levels and IGFBP-3 levels are complex traits and are influenced by a number of interacting genetic and nongenetic factors...
  81. pmc Advanced glycosylation end products (AGEs), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in patients with type 2 diabetes mellitus
    M E Garay Sevilla
    , Universidad de Guanajuato, 20 de Enero 929, , Mexico
    Diabetes Metab Res Rev 16:106-13. 2000
    ..of complications in diabetes, and the possible roles of insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are not clearly established...
  82. ncbi Continuous s.c. infusion rather than twice-daily injections of IGF-I more effectively increases serum IGF binding protein-3 in female monkeys
    M E Wilson
    Yerkes Primate Research Center, Emory University, 2409 Taylor Lane, Lawrenceville, GA 30043, USA
    Eur J Endocrinol 141:303-12. 1999
    ..However, studies in monkeys indicate that acute or continuous infusion of IGF-I effectively increases serum IGFBP-3...
  83. ncbi Association of insulin-like growth factor I and insulin-like growth factor-binding protein-3 with intelligence quotient among 8- to 9-year-old children in the Avon Longitudinal Study of Parents and Children
    David Gunnell
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Pediatrics 116:e681-6. 2005
    ..We are aware of no studies that investigated the association of IGF-I levels with IQ in population samples of normal children...
  84. ncbi Insulin-like growth factor-binding protein-3 (IGFBP-3) but not insulin-like growth factor-I (IGF-I) remains elevated in euthyroid TSH-suppressed Graves' disease
    W M Wan Nazaimoon
    Division of Endocrinology, Institute for Medical Research, Kuala Lumpur, Malaysia
    Horm Metab Res 30:213-6. 1998
    ..As such patients have been shown to have higher risk for atrial fibrillation, the significance and possible role of IGFBP-3 in these conditions should be further elucidated in future studies...
  85. ncbi The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity
    D R Clemmons
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7170, USA
    J Clin Endocrinol Metab 85:1518-24. 2000
    ..Further studies will be required to determine the long-term safety and efficacy of this combination in patients with insulin resistance and diabetes...
  86. pmc Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Exp Eye Res 85:492-501. 2007
    ..The differential localization and effect(s) on apoptosis suggest that the effects of IGFBP3 are likely tissue compartment and receptor specific and may be regulated by glycosylation...
  87. ncbi The role of IGF binding protein-3 as a parameter of activity in acromegalic patients
    I Halperin
    Department of Endocrinology, Hospital Clinic, Barcelona University, Spain
    Eur J Endocrinol 141:145-8. 1999
    ..We investigated its potential value as a parameter of acromegaly activity or remission in comparison with IGF-I, taking GH suppression below 2 microg/l after glucose load as the normal standard...
  88. ncbi Centralized blood processing for the selenium and vitamin E cancer prevention trial: effects of delayed processing on carotenoids, tocopherols, insulin-like growth factor-I, insulin-like growth factor binding protein 3, steroid hormones, and lymphocyte vi
    Alan R Kristal
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:727-30. 2005
    ..Longer processing delays, however, have small but statistically significant effects on many analytes and substantially decrease lymphocyte viability...
  89. pmc Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro
    JHERI J DUPART
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer 8:99. 2009
    ..To test this hypothesis, we manipulated IGFBP3 levels in two imatinib-responsive GIST cell lines and observed cell viability after drug treatment...
  90. ncbi Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains
    Masayuki Itoh
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neuropathol Exp Neurol 66:117-23. 2007
    ..IGFBP3 overexpression due to lack of MeCP2 may lead to delayed brain maturation...
  91. ncbi Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 response to growth hormone is impaired in HIV-infected children
    Mariangela Rondanelli
    Department of Internal Medicine and Medical Therapy, University of Pavia, 27100 Pavia, Italy
    AIDS Res Hum Retroviruses 18:331-9. 2002
    ..It appears that circadian GH secretion is normal in children with HIV infection, but the response to exogenous GH with regard to IGF-I and IGFBP-3 production is impaired, indicating a degree of GH insensitivity in such children...
  92. ncbi Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice
    T Modric
    Departments of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
    Endocrinology 142:1958-67. 2001
    ..Our data indicate that overexpression of IGFBP-3 is associated with modest intrauterine and postnatal growth retardation despite elevated circulating IGF-I levels...
  93. doi Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents
    J L Y Mong
    Department of Biochemistry, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Obes (Lond) 33:1446-53. 2009
    ..Five single-nucleotide polymorphisms (SNPs) at IGF-binding protein-3 (IGFBP3) were genotyped to find their associations with IGF-1 activity level and common clinical metabolic traits...
  94. pmc The C terminus of p53 family proteins is a cell fate determinant
    Kelly Lynn Harms
    University of Alabama Birmingham, Department of Cell Biology, MCLM 660, 1918 University Blvd, Birmingham, AL 35294, USA
    Mol Cell Biol 25:2014-30. 2005
    ..Taken together, our data suggest a novel mechanism by which p53 family proteins differentially regulate gene expression and provide an insight for designing a combined therapy for cancer treatment...
  95. ncbi Perinatal hypoxia-ischemia decreased neuronal but increased cerebral vascular endothelial IGFBP3 expression
    W H Lee
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202 5119, USA
    Endocrine 11:181-8. 1999
    ..In addition, increased endothelial IGFBP3 may modulate the interaction of IGFs with IGF-I receptors at the site of injury and/or act independently on endothelial cell growth...
  96. doi Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis
    Yanhe Lue
    Division of Endocrinology, Department of Medicine, Los Angeles Biomedical Research Institute and Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 151:350-7. 2010
    ..We have shown previously that IGF binding protein 3 (IGFBP3) gene expression is up-regulated in human testis when germ cell apoptosis is induced by ..
  97. ncbi Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells
    Ho Young Lee
    Unit 432, Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 96:1536-48. 2004
    ..We thus evaluated the therapeutic potential of the combination of IGFBP-3 and SCH66336, a farnesyltransferase inhibitor that blocks Ras activation, in NSCLC cell lines...
  98. doi Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells
    Tetsuya Maekawa
    Department of Biology, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700 8530, Japan
    Zoolog Sci 26:131-8. 2009
    ....
  99. ncbi Increased 24 h mean insulin-like growth factor binding protein-3 proteolytic activity in pubertal type 1 diabetic boys
    I Zachrisson
    Astrid Lindgren Children s Hospital, Karolinska Hospital and Institute, Stockholm, Sweden
    Growth Horm IGF Res 10:324-31. 2000
    ....
  100. ncbi Horse conceptuses secrete insulin-like growth factor-binding protein 3
    A Herrler
    The Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom
    Biol Reprod 62:1804-11. 2000
    ..IGFBP3 in the horse conceptus capsule may enhance or modulate the action of IGFs on the developing conceptus...
  101. ncbi [Developmental expression changes of IGF2 and IGFBP3 genes in adipose tissue of two pig breeds]
    Yu Jiao Guo
    College of Animal Science and Technology, Sichuan Agricultural University, Ya an 625014, China
    Yi Chuan 30:602-6. 2008
    ..The expression decrease of IGF2 may be related to adipocyte hyperplasia...

Research Grants76

  1. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  2. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2007
    ..abstract_text> ..
  3. Insulin and IGF In female colon, breast, uterine cancer
    Howard Strickler; Fiscal Year: 2005
    ....
  4. Targeting the IGF-1 System in Retinal Angiogenesis
    Maria Grant; Fiscal Year: 2003
    ..Targeting the IGF-IR and IGFBP-3 in this manner will provide a tool for understanding the role of the IGF-1 system in retinal vascular growth and may provide novel ways to inhibit retinal angiogenesis. ..
  5. Targeting the IGF-1 System in Retinal Angiogenesis
    Maria Grant; Fiscal Year: 2006
    ..Targeting the IGF-IR and IGFBP-3 in this manner will provide a tool for understanding the role of the IGF-1 system in retinal vascular growth and may provide novel ways to inhibit retinal angiogenesis. ..
  6. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
    ..abstract_text> ..
  7. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2007
    ..abstract_text> ..
  8. IGF-I LEVELS, IGF-I GENOTYPE, AND PROSTATE CANCER
    Noel Weiss; Fiscal Year: 2002
    ..abstract_text> ..
  9. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  10. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..abstract_text> ..
  11. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ....
  12. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..abstract_text> ..
  13. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ....
  14. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..abstract_text> ..
  15. IGF binding protein-3 in beta cell apoptosis
    ROBERT FERRY JR; Fiscal Year: 2005
    ....
  16. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2010
    ..biomarkers of breast cancer risk: mammographic density;plasma insulin-like growth factor 1 (IGF-1), IGF binding protein 3, estrone, estradiol, androstenedione and sex hormone binding globulin...
  17. Green Tea and Reduction of Breast Cancer Risk
    MINDY KURZER; Fiscal Year: 2009
    ..biomarkers of breast cancer risk: mammographic density; plasma insulin-like growth factor 1 (IGF-1), IGF binding protein 3, estrone, estradiol, androstenedione and sex hormone binding globulin...
  18. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2010
    ....
  19. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    DANIELLE ROBERTSON; Fiscal Year: 2009
    ....
  20. Pregnancy Estrogens, Diet, and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2005
    ..associated with increased growth factor levels in nipple aspirate fluid, including EGF, TGFalpha and IGF-1/IGF binding protein 3. These aims will be studied in 200 pregnant women attending the Maternity Clinic at Solna in NAF will be ..
  21. Stem Cells and Perinatal Factors for Breast Cancer Risk
    Chung cheng Hsieh; Fiscal Year: 2005
    ..The study seeks to obtain information on parameters of perinatal cell proliferation relevant to intervening steps between intrauterine hormone exposure and subsequent cancer risk. ..
  22. Muscular Dystrophy Cooperative Research Center
    RICHARD MOXLEY; Fiscal Year: 2007
    ..Projects 1, 2, & 3 interact with the Repository Core and this Core will interact with the other MDCRCs. ..