Gene Symbol: IGF2BP1
Description: insulin like growth factor 2 mRNA binding protein 1
Alias: CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin-like growth factor 2 mRNA-binding protein 1, IGF-II mRNA-binding protein 1, IGF2 mRNA-binding protein 1, VICKZ family member 1, ZBP-1, coding region determinant-binding protein, insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP, zipcode-binding protein 1
Species: human
Products:     IGF2BP1

Top Publications

  1. Vikesaa J, Hansen T, Jønson L, Borup R, Wewer U, Christiansen J, et al. RNA-binding IMPs promote cell adhesion and invadopodia formation. EMBO J. 2006;25:1456-68 pubmed
    ..Taken together, our results indicate that RNA-binding proteins exert profound effects on cellular adhesion and invasion during development and cancer formation. ..
  2. Kobel M, Weidensdorfer D, Reinke C, Lederer M, Schmitt W, Zeng K, et al. Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma. Oncogene. 2007;26:7584-9 pubmed
    ..ovarian carcinomas, 30 serous borderline tumors of the ovary and five normal ovaries revealed de novo synthesis of IMP1 in 69% of ovarian carcinomas...
  3. Rackham O, Brown C. Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs. EMBO J. 2004;23:3346-55 pubmed
    ..that the fragile X mental retardation protein (FMRP) isoform 18 and the human zipcode-binding protein 1 ortholog IMP1, an RNA transport factor, were present on common mRNAs...
  4. Hansen T, Hammer N, Nielsen J, Madsen M, Dalbaeck C, Wewer U, et al. Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol. 2004;24:4448-64 pubmed
    Insulin-like growth factor II mRNA-binding protein 1 (IMP1) belongs to a family of RNA-binding proteins implicated in mRNA localization, turnover, and translational control...
  5. Nielsen J, Christiansen J, Lykke Andersen J, Johnsen A, Wewer U, Nielsen F. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999;19:1262-70 pubmed
    ..The results imply that cytoplasmic 5' UTR-binding proteins control IGF-II biosynthesis during late mammalian development. ..
  6. Noubissi F, Goswami S, Sanek N, Kawakami K, Minamoto T, MOSER A, et al. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009;69:8572-8 pubmed publisher
    ..The newly described mode of regulation of GLI1 seems to be important to several functions of Wnt, including survival and proliferation of colorectal cancer cells. ..
  7. Yisraeli J. VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. Biol Cell. 2005;97:87-96 pubmed publisher
    ..Such a 'post-transcriptional operon' model, as proposed by Keene and Tenenbaum [(2002) Mol. Cell 9, 1161-1167], can explain the differential, integrated action of multiple RNA-binding proteins on mRNA targets...
  8. Ioannidis P, Kottaridi C, Dimitriadis E, Courtis N, Mahaira L, Talieri M, et al. Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors. Cancer Lett. 2004;209:245-50 pubmed
    ..These findings confirm that CRD-BP expression is restricted in tumors; the frequency of its de novo expression may vary according to tumor type and appears to be an early event in the transformation process. ..
  9. Gu L, Shigemasa K, Ohama K. Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer. Int J Oncol. 2004;24:671-8 pubmed
    ..IMP mRNA expression levels might play an important role in ovarian cancer development and progression, and IMP-1 overexpression is a prognostic marker for patients with ovarian cancer. ..

More Information


  1. Lemm I, Ross J. Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant. Mol Cell Biol. 2002;22:3959-69 pubmed
    ..Additional mapping experiments suggest that the CRD is bipartite, with several upstream translation pause sites and a downstream endonuclease cleavage site. ..
  2. Runge S, Nielsen F, Nielsen J, Lykke Andersen J, Wewer U, Christiansen J. H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem. 2000;275:29562-9 pubmed
    ..The results suggest that IMP participates in H19 RNA localization and provides a link between the IGF-II and H19 genes at post-transcriptional events during mammalian development. ..
  3. Nielsen F, Nielsen J, Kristensen M, Koch G, Christiansen J. Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains. J Cell Sci. 2002;115:2087-97 pubmed
    ..Here we characterise the trafficking of GFP-IMP1 fusion proteins and determine the structural determinants for proper cytoplasmic localization...
  4. Stöhr N, Lederer M, Reinke C, Meyer S, Hatzfeld M, Singer R, et al. ZBP1 regulates mRNA stability during cellular stress. J Cell Biol. 2006;175:527-34 pubmed
    ..We identify that Zipcode-binding protein 1 (ZBP1) regulates the cytoplasmic fate of specific mRNAs in nonstressed cells and is a key regulator of mRNA turnover ..
  5. Ioannidis P, Mahaira L, Papadopoulou A, Teixeira M, Heim S, Andersen J, et al. 8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas. Int J Cancer. 2003;104:54-9 pubmed
    The coding region determinant binding protein (CRD-BP) was isolated by virtue of its high affinity to the c-myc mRNA coding region stability determinant and shown to shield this message from nucleolytic attack, prolonging its half-life...
  6. Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007;8:1052-60 pubmed
    ..Using reporter assays and knockdown experiments, we showed that the putative RNA-binding protein RBM4 is required for microRNA-guided gene regulation. ..
  7. Stöhr N, Köhn M, Lederer M, Glass M, Reinke C, Singer R, et al. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012;26:176-89 pubmed publisher
    In primary neurons, the oncofetal RNA-binding protein IGF2BP1 (IGF2 mRNA-binding protein 1) controls spatially restricted β-actin (ACTB) mRNA translation and modulates growth cone guidance...
  8. Noubissi F, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, et al. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature. 2006;441:898-901 pubmed
  9. Yaniv K, Yisraeli J. The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis. Gene. 2002;287:49-54 pubmed
    ..This paper will review these data and suggest a model for the role of Vg1 RBP and its homologs in embryonic development and carcinogenesis. ..
  10. Pillas D, Hoggart C, Evans D, O Reilly P, Sipilä K, Lähdesmäki R, et al. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet. 2010;6:e1000856 pubmed publisher
    ..The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer...
  11. Liao B, Patel M, Hu Y, Charles S, Herrick D, Brewer G. Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells. J Biol Chem. 2004;279:48716-24 pubmed
    ..Thus, we have identified a dominant function for CRD-BP in cell proliferation of human K562 cells, involving a possible IGF-II-dependent mechanism that appears independent of its ability to serve as a c-myc mRNA masking protein. ..
  12. Doyle G, Betz N, Leeds P, Fleisig A, Prokipcak R, Ross J. The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. Nucleic Acids Res. 1998;26:5036-44 pubmed
    ..Recombinant mouse CRD-BP binds specifically to c- myc CRD RNA in vitro and reacts with antibody against human CRD-BP. Most of the CRD-BP in the cell is cytoplasmic and co-sediments with ribosomal subunits. ..
  13. Zhou Y, Rong L, Lu J, Pan Q, Liang C. Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. J Virol. 2008;82:5683-92 pubmed publisher
    ..In this study, we report a new HIV-1 Gag-binding factor named insulin-like growth factor II mRNA binding protein 1 (IMP1)...
  14. Huttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, et al. Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature. 2005;438:512-5 pubmed
    ..This localization requires the oncofetal protein ZBP1 (Zipcode binding protein 1), which binds to a conserved 54-nucleotide element in the 3'-untranslated region of the beta-actin mRNA ..
  15. Er H, Altındiş M, Aşık G, Demir C. [Molecular epidemiology of beta-lactamases in ceftazidime-resistant Pseudomonas aeruginosa isolates]. Mikrobiyol Bul. 2015;49:156-65 pubmed
  16. Lottrup G, Belling K, Leffers H, Nielsen J, Dalgaard M, Juul A, et al. Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents. Mol Hum Reprod. 2017;23:339-354 pubmed publisher
    ..2 (WISP2), hydroxyprostaglandin dehydrogenase (HPGD) and insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1), whose expression changes were validated at the protein level...
  17. Lin E, Karakasheva T, Lee D, Lee J, Long Q, Bass A, et al. Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries. PLoS Genet. 2017;13:e1006938 pubmed publisher
    ..In addition, we highlighted genes that may be common drivers of adenocarcinomas specifically, such as IGF2BP1, which suggests a possible link between embryonic development and tumor subtype...
  18. Surrey V, Zöller C, Lork A, Moradi M, Balk S, Dombert B, et al. Impaired Local Translation of β-actin mRNA in Ighmbp2-Deficient Motoneurons: Implications for Spinal Muscular Atrophy with respiratory Distress (SMARD1). Neuroscience. 2018;386:24-40 pubmed publisher
    ..protein levels at the growth cone of Ighmbp2-deficient motoneurons which was accompanied by reduced level of IMP1/ZBP1, a known interactor of β-actin mRNA...
  19. Nguyen N, de Oliveira Andrade F, Jin L, Zhang X, Macon M, Cruz M, et al. Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice. Breast Cancer Res. 2017;19:77 pubmed publisher
    ..to cancer treatments (SLC26A3), poor prognosis (ID4, JAM3, TBX2), and impaired anticancer immunity (EGR3, ZBP1)...
  20. Fallini C, Donlin Asp P, Rouanet J, Bassell G, Rossoll W. Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons. J Neurosci. 2016;36:3811-20 pubmed publisher
    ..Importantly, overexpression of two mRNA-binding proteins, HuD and IMP1, restoresGAP43mRNA and protein levels in growth cones and rescues axon outgrowth defects in SMA neurons...
  21. Sáez Freire M, Blanco Gómez A, Castillo Lluva S, Gómez Vecino A, Galvis Jiménez J, Martín Seisdedos C, et al. The biological age linked to oxidative stress modifies breast cancer aggressiveness. Free Radic Biol Med. 2018;120:133-146 pubmed publisher
    ..The levels of expression of Zbp1 located on chromosome 2, a gene related to necroptosis and inflammation, positively correlated with the grade of ..
  22. Glinka M, Herrmann T, Funk N, Havlicek S, Rossoll W, Winkler C, et al. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. Hum Mol Genet. 2010;19:1951-66 pubmed publisher
    ..Several beta-actin mRNA-binding and transport proteins have been identified, including ZBP1, ZBP2 and hnRNP-R...
  23. Matsumura Y, Peirano G, Motyl M, Adams M, Chen L, Kreiswirth B, et al. Global Molecular Epidemiology of IMP-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..This study highlights the importance of surveillance programs using the latest molecular techniques for providing insight into the characteristics and global distribution of Enterobacteriaceae with blaIMP genes. ..
  24. Faccone D, Martino F, Pasteran F, Albornoz E, Biondi E, Vazquez M, et al. Multiple clones of metallo-β-lactamase-producing Acinetobacter ursingii in a children hospital from Argentina. Infect Genet Evol. 2019;67:145-149 pubmed publisher
    ..ursingii in Argentina. The inclusion of A. ursingii species to the Acinetobacter MLST-Pasteur scheme allows deeper molecular characterization and a better understanding about the epidemiology of this germen. ..
  25. Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli S, et al. Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells. Sci Rep. 2018;8:914 pubmed publisher
    ..Damaged mtDNA first enters the cytoplasm, where it binds to Z-DNA binding protein 1 (ZBP1) and triggers inflammation via the TANK-binding kinase 1 /interferon regulatory factor 3 signaling pathway...
  26. Martins A, Bail L, Ito C, da Silva Nogueira K, Dalmolin T, Martins A, et al. Antimicrobial activity of plazomicin against Enterobacteriaceae-producing carbapenemases from 50 Brazilian medical centers. Diagn Microbiol Infect Dis. 2018;90:228-232 pubmed publisher
    ..The MICs of plazomicin against CPE were lower than those of other aminoglycosides. Plazomicin is a promising drug for the treatment of CPE infections. ..
  27. Kim H, Kim H, Lee J, Yoon S, Yong D. Rapid detection of Pseudomonas aeruginosa and Acinetobacter baumannii Harboring bla(VIM-2), bla(IMP-1) and bla(OXA-23) genes by using loop-mediated isothermal amplification methods. Ann Lab Med. 2016;36:15-22 pubmed publisher
    ..Fifty two strains of the 75 CRAB isolates contained bla(OXA-23), but none contained bla(VIM-2) and bla(IMP-1) alleles. Our results demonstrate the usefulness of LAMP for the diagnosis of CRPA and CRAB. ..
  28. Browne J, Leir S, Eggener S, Harris A. Region-specific innate antiviral responses of the human epididymis. Mol Cell Endocrinol. 2018;473:72-78 pubmed publisher
    ..In addition, paired box 2 (PAX2), which was implicated in regulating antiviral response pathways, is required for basal expression of the DNA sensor, Z-DNA binding protein (ZBP1) and type I interferon, in caput but not in cauda cells.
  29. Liew S, Rajasekaram G, Puthucheary S, Chua K. Detection of VIM-2-, IMP-1- and NDM-1-producing multidrug-resistant Pseudomonas aeruginosa in Malaysia. J Glob Antimicrob Resist. 2018;13:271-273 pubmed publisher
    ..aeruginosa isolates. The emergence of imipenemase 1 (IMP-1)- and New Delhi metallo-?-lactamase 1 (NDM-1)-producing P. aeruginosa in Malaysia maybe travel-associated. ..
  30. Kuriakose T, Zheng M, Neale G, Kanneganti T. IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018;200:1489-1495 pubmed publisher
    ..cell death in IRF1-deficient cells during IAV infection correlates with reduced levels of Z-DNA binding protein 1 (ZBP1), a key molecule mediating IAV-induced inflammatory and cell death responses...
  31. Kesavardhana S, Kuriakose T, Guy C, Samir P, Malireddi R, Mishra A, et al. ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. J Exp Med. 2017;214:2217-2229 pubmed publisher
    ..We have recently identified Z-DNA-binding protein 1 (ZBP1) as an innate sensor of influenza A virus (IAV)...
  32. Gaynes J, Otsuna H, Campbell D, Manfredi J, Levine E, Chien C. The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo. PLoS ONE. 2015;10:e0134751 pubmed publisher
    Attractive growth cone turning requires Igf2bp1-dependent local translation of β-actin mRNA in response to external cues in vitro...
  33. Turton J, Wright L, Underwood A, Witney A, Chan Y, Al Shahib A, et al. High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom. J Clin Microbiol. 2015;53:2622-31 pubmed publisher
    ..WGS of widely found international lineages such as ST-111 provides the necessary resolution to inform epidemiological investigations and intervention policies. ..
  34. Kato T, Hayama S, Yamabuki T, Ishikawa N, Miyamoto M, Ito T, et al. Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. Clin Cancer Res. 2007;13:434-42 pubmed
    ..These results suggest that IMP-1 expression is likely to play important roles in lung cancer development and progression, and that IMP-1 is a prognostic biomarker and a promising therapeutic target for lung cancer. ..
  35. Chen B, Xu J, He X, Xu H, Li G, Du H, et al. A Genome-Wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth. PLoS ONE. 2015;10:e0137087 pubmed publisher
    ..01 or P < 0.05) the expression of growth-related genes including CEBPB, FBXO32, GH, GHR, IGF1R, IGF2R, IGF2BP1, IGF2BP3, INSR, PDK1 and PDK4. Moreover, 18 SNPs were identified in FOXO3. G66716193A was significantly (P < 0...
  36. Villa J, Arana D, Viedma E, Perez Montarelo D, Chaves F. Characterization of mobile genetic elements carrying VIM-1 and KPC-2 carbapenemases in Citrobacter freundii isolates in Madrid. Int J Med Microbiol. 2017;307:340-345 pubmed publisher
    ..The dissemination of the blaVIM-1 gene among various clones suggests a successful horizontal transfer of integron carrying elements that play a dominant role in the development of multidrug resistance in Enterobacteriaceae. ..
  37. Srisrattakarn A, Lulitanond A, Wilailuckana C, Charoensri N, Wonglakorn L, Piyapatthanakul S, et al. Modification and evaluation of the Carba NP test by use of paper strip for simple and rapid detection of carbapenemase-producing Enterobacteriaceae. World J Microbiol Biotechnol. 2016;32:117 pubmed publisher
  38. Ito Horiyama T, Ishii Y, Ito A, Sato T, Nakamura R, Fukuhara N, et al. Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases. Antimicrob Agents Chemother. 2016;60:4384-6 pubmed publisher
    ..0050, and 0.024 ?M(-1) s(-1), respectively, which were more than 260-fold lower than that for meropenem. Only slight hydrolysis of S-649266 against KPC-3 was observed. NDM-1 hydrolyzed meropenem 3-fold faster than S-649266 at 200 ?M. ..
  39. Kayama S, Ohge H, Sugai M. Rapid discrimination of blaIMP-1, blaIMP-6, and blaIMP-34 using a multiplex PCR. J Microbiol Methods. 2017;135:8-10 pubmed publisher
    ..We developed an amplification refractory mutation system (ARMS) PCR assay enabling rapid, sequence independent, identification of these variants. ..
  40. Meristoudis C, Trangas T, Lambrianidou A, Papadopoulos V, Dimitriadis E, Courtis N, et al. Systematic analysis of the contribution of c-myc mRNA constituents upon cap and IRES mediated translation. Biol Chem. 2015;396:1301-13 pubmed publisher
    ..by approximately 50%, regardless of the expression levels of the wild type CRD- binding protein (CRD-BP/IMP1)...
  41. Mai Y, Gao G. Expression of IMP1 enhances production of murine leukemia virus vector by facilitating viral genomic RNA packaging. PLoS ONE. 2010;5:e15881 pubmed publisher
    ..Here, we report that expression of the insulin-like growth factor II mRNA binding protein 1 (IMP1) enhanced the production of infectious MLV vector...
  42. Nwokafor C, Sellers R, Singer R. IMP1, an mRNA binding protein that reduces the metastatic potential of breast cancer in a mouse model. Oncotarget. 2016;7:72662-72671 pubmed publisher
    ..carcinoma cells derived from primary mammary tumors have reduced levels of an RNA binding protein IMP1/ZBP1/IGF2BP1, required for β-actin mRNA localization...
  43. Kuriakose T, Kanneganti T. ZBP1: Innate Sensor Regulating Cell Death and Inflammation. Trends Immunol. 2018;39:123-134 pubmed publisher
    Z-DNA-binding protein 1 (ZBP1), initially reported as an interferon (IFN)-inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypic interaction motif ..
  44. Demiray T, Koroglu M, Ozbek A, Altindis M. A rare cause of infection, Raoultella planticola: emerging threat and new reservoir for carbapenem resistance. Infection. 2016;44:713-717 pubmed
    ..infections, which may result from misidentification, are more common than expected , and it is not unlikely that there will be a gradual increase and spread in multidrug-resistant isolates. ..
  45. Kawakami Y, Kubota N, Ekuni N, Suzuki Yamamoto T, Kimoto M, Yamashita H, et al. Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells. Biosci Biotechnol Biochem. 2009;73:1811-7 pubmed
    ..We propose that expression of 8S-LOX and 15S-LOX-2 suppresses CRD-BP/IMP-1 expression, resulting in inhibition of human prostate carcinoma PC-3 cell proliferation. ..
  46. Segawa T, Matsui M, Suzuki M, Tsutsui A, Kuroda M, Shibayama K, et al. Utilizing the Carba NP test as an indicator of expression level of carbapenemase genes in Enterobacteriaceae. J Microbiol Methods. 2017;133:35-39 pubmed publisher
  47. Rensburg G, Mackedenski S, Lee C. Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. PLoS ONE. 2017;12:e0171196 pubmed publisher
    ..The new molecular insights provided in this study have important implications for understanding the oncogenic function of CRD-BP and development of specific inhibitors against CRD-BP-MITF RNA interaction. ..
  48. Abdullah C, Korkaya H, Iizuka S, Courtneidge S. SRC Increases MYC mRNA Expression in Estrogen Receptor-Positive Breast Cancer via mRNA Stabilization and Inhibition of p53 Function. Mol Cell Biol. 2018;38: pubmed publisher
    ..receptor-positive breast cancer cells via SRC-dependent effects on a recently described RNA-binding protein, IMP1 with an N-terminal deletion (ΔN-IMP1)...
  49. Milev M, Brown C, Mouland A. Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1. Retrovirology. 2010;7:41 pubmed publisher
    ..We identified where the virus-host interactions between Gag and Staufen1 and Gag and IMP1 (also known as VICKZ1, IGF2BP1 and ZBP1) occur in cells...
  50. de Vasconcellos J, Tumburu L, Byrnes C, Lee Y, Xu P, Li M, et al. IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts. Proc Natl Acad Sci U S A. 2017;114:E5664-E5672 pubmed publisher
    ..element of the heterochronic let-7 miRNA pathway, the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), for its potential to affect the hemoglobin profiles in human erythroblasts...
  51. Zirkel A, Lederer M, Stöhr N, Pazaitis N, Huttelmaier S. IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic Acids Res. 2013;41:6618-36 pubmed publisher
    The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) controls the migration and invasiveness of primary as well as tumor-derived cells in vitro...
  52. Kessler S, Lederer E, Laggai S, Golob Schwarzl N, Hosseini K, Petzold J, et al. IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer. Oncotarget. 2017;8:89736-89745 pubmed publisher
    ..0% showed strong and 86.0% low staining intensity. 72.4% of the tumor samples were IMP1 positive, but IMP1 showed lower expression in tumor tissue compared to control tissues...
  53. Doyle G, Bourdeau Heller J, Coulthard S, Meisner L, Ross J. Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein. Cancer Res. 2000;60:2756-9 pubmed
    ..4 and 20 copies). Despite their proximity, CRD-BP and HER-2/neu genes can be amplified independently. Amplification of a gene that might up-regulate c-Myc abundance could accelerate breast cancer. ..
  54. Gorselink M, Drost M, Coumans W, van Kranenburg G, Hesselink R, Van der Vusse G. Impaired muscular contractile performance and adenine nucleotide handling in creatine kinase-deficient mice. Am J Physiol Endocrinol Metab. 2001;281:E619-25 pubmed
    ..ATP regeneration via the adenylate kinase pathway is a likely cause of reduced basal adenine nucleotide levels in CK(-/-) mice...
  55. Stoskus M, Eidukaite A, Griskevicius L. Defining the significance of IGF2BP1 overexpression in t(12;21)(p13;q22)-positive leukemia REH cells. Leuk Res. 2016;47:16-21 pubmed publisher
    The IGF2 mRNA binding protein 1 (IGF2BP1) belongs to a family of regulatory RNA-binding proteins and controls stability, transport or translation of its target transcripts...
  56. Stoskus M, Vaitkevičienė G, Eidukaite A, Griskevicius L. ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia. Blood Cells Mol Dis. 2016;57:30-4 pubmed publisher
    The oncofetal RNA-binding protein IGF2BP1 (IGF2 mRNA binding protein 1) is overexpressed in a subset of cancers and promotes cell cycle, migration and aggressive phenotype by regulating post-transcriptionally a number of key mRNAs (e...
  57. Gu W, Katz Z, Wu B, Park H, Li D, Lin S, et al. Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1. J Cell Sci. 2012;125:81-91 pubmed publisher
    ..We have previously reported that silencing of the expression of the zipcode-binding protein IMP1/ZBP1 in breast tumor patients is associated with metastasis...
  58. Weinlich S, Huttelmaier S, Schierhorn A, Behrens S, Ostareck Lederer A, Ostareck D. IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. RNA. 2009;15:1528-42 pubmed publisher
    ..Tob)-aptamer affinity chromatography, we identified the Insulin-like growth factor-II mRNA-binding protein 1 (IGF2BP1) as a factor that interacts with both, the HCV 5'UTR and 3'UTR...
  59. Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, et al. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology. 2014;59:1900-11 pubmed publisher
    ..We focused our subsequent analyses on the Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 1 (IGF2BP1) representing the most strongly up-regulated RBP in HCC in our cohort...
  60. Faye M, Beug S, Graber T, Earl N, Xiang X, Wild B, et al. IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1. Oncogene. 2015;34:1532-41 pubmed publisher
    ..We report here that insulin-like growth factor 2-binding protein 1 (IGF2BP1), an oncofetal protein, is expressed in RMS patient-derived cell lines and in primary tumours where it drives ..
  61. Blake D, Pastor Fernández I, Nolan M, Tomley F. Recombinant anticoccidial vaccines - a cup half full?. Infect Genet Evol. 2017;55:358-365 pubmed publisher
    ..data are now becoming available for antigens such as apical membrane antigen 1 (AMA1) and immune mapped protein 1 (IMP1) and more are anticipated as high-capacity, high-throughput sequencing technologies become increasingly accessible.
  62. Shirvani G, Shockravi A, Amini M, Saemian N. Synthesis of (2-mercaptoacetyl)-L-[2-14 C]tryptophan as a selective metallo-?-lactamase inhibitor via [2-14 C]indole based on chiral pool strategy. J Labelled Comp Radiopharm. 2017;60:130-134 pubmed publisher
    ..The overall synthesis was performed in 10 steps with the overall radiochemical yield 3.6% on the basis of the barium [14 C]carbonate as a starting material...
  63. Patel G, Bag J. IMP1 interacts with poly(A)-binding protein (PABP) and the autoregulatory translational control element of PABP-mRNA through the KH III-IV domain. FEBS J. 2006;273:5678-90 pubmed
    ..ribonucleoprotein complex by the binding of PABP, insulin-like growth factor II mRNA binding protein-1 (IMP1) and the unr gene encoded polypeptide (UNR) to the adenine-rich autoregulatory sequence (ARS) located at the 5' ..
  64. Sorenson E, Khanin R, Bamboat Z, Cavnar M, Kim T, Sadot E, et al. Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation. PLoS ONE. 2017;12:e0176562 pubmed publisher
    ..Five of these recurrently deleted miRs targeted the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) gene product, and a correlating 100-fold upregulation of IGF2BP1 mRNA was seen in tumor specimens...
  65. Gu G, Sederberg M, Drachenberg M, South S. IGF2BP1: a novel IGH translocation partner in B acute lymphoblastic leukemia. Cancer Genet. 2014;207:332-4 pubmed publisher
    ..Chromosomal microarray analysis (CMA) showed the breakpoint at the 5 prime end of the IGF2BP1 gene located at 17q21.32...
  66. Hinchliffe P, González M, Mojica M, Gonzalez J, Castillo V, Saiz C, et al. Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Proc Natl Acad Sci U S A. 2016;113:E3745-54 pubmed publisher
    ..d-BTZ complexes most closely resemble β-lactam binding to B1 MBLs, but feature an unprecedented disruption of the D120-zinc interaction. Cross-class MBL inhibition therefore arises from the unexpected versatility of BTZ binding. ..
  67. Chao J, Patskovsky Y, Patel V, Levy M, Almo S, Singer R. ZBP1 recognition of beta-actin zipcode induces RNA looping. Genes Dev. 2010;24:148-58 pubmed publisher
    ..The spacing between the RNA sequences is consistent with the structure of IMP1 KH34, the human ortholog of ZBP1, that we solved by X-ray crystallography...
  68. Mahapatra L, Andruska N, Mao C, Le J, Shapiro D. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol. 2017;10:818-827 pubmed publisher
    The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP1), binds to and stabilizes c-Myc, ?-TrCP1, and other oncogenic mRNAs, leading to increased expression of the proteins encoded by its ..
  69. Ramos A, Cayô R, Carvalhaes C, Jové T, da Silva G, Sancho F, et al. Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne blaIMP-1 in a Tertiary Hospital. Antimicrob Agents Chemother. 2018;62: pubmed publisher
  70. Noubissi F, Kim T, Kawahara T, Aughenbaugh W, Berg E, Longley B, et al. Role of CRD-BP in the growth of human basal cell carcinoma cells. J Invest Dermatol. 2014;134:1718-1724 pubmed publisher
    ..We also describe the generation and characterization of a human BCC cell line. This cell line was utilized to demonstrate the importance of CRD-BP-dependent regulation of GLI1 expression and activities in the development of BCC. ..
  71. Zhang X, Mofers A, Hydbring P, Olofsson M, Guo J, Linder S, et al. MYC is downregulated by a mitochondrial checkpoint mechanism. Oncotarget. 2017;8:90225-90237 pubmed publisher
    ..Our data demonstrates the existence of a homeostasis mechanism whereby mitochondrial function controls MYC expression...
  72. Yang F, Xue X, Zheng L, Bi J, Zhou Y, Zhi K, et al. Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. FEBS J. 2014;281:802-13 pubmed publisher
    ..assays confirmed that GHET1 physically associates with insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) and enhances the physical interaction between c-Myc mRNA and IGF2BP1, consequently increasing the stability of c-..
  73. Hu L, Li X, Liu Q, Xu J, Ge H, Wang H, et al. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Oncogene. 2017;36:1145-1156 pubmed publisher
    ..Overall, our findings provide a novel drug target that may serve as the rationale for the development of a new therapeutic approach. ..
  74. Zhou Y, Rong L, Zhang J, Aloysius C, Pan Q, Liang C. Insulin-like growth factor II mRNA binding protein 1 modulates Rev-dependent human immunodeficiency virus type 1 RNA expression. Virology. 2009;393:210-20 pubmed publisher
    ..Results of our recent studies show that overexpression of insulin-like growth factor II mRNA binding protein 1 (IMP1) inhibits production of infectious HIV-1 particles through adversely affecting virus maturation...
  75. Yuan P, Meng L, Wang N. SOX12 upregulation is associated with metastasis of hepatocellular carcinoma and increases CDK4 and IGF2BP1 expression. Eur Rev Med Pharmacol Sci. 2017;21:3821-3826 pubmed
    ..HepG2 cells were used as in vitro cell model to assess the effect of SOX12 on CDK4 and IGF2BP1 expression...
  76. Donlin Asp P, Fallini C, Campos J, Chou C, Merritt M, Phan H, et al. The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly. Cell Rep. 2017;18:1660-1673 pubmed publisher
    ..of biochemical and advanced imaging methods to demonstrate that SMN promotes the molecular interaction between IMP1 protein and the 3' UTR zipcode region of β-actin mRNA, leading to assembly of messenger ribonucleoprotein (mRNP) ..
  77. Papagiannitsis C, Medvecky M, Chudějová K, Skálová A, Rotova V, Spanělová P, et al. Molecular Characterization of Carbapenemase-Producing Pseudomonas aeruginosa of Czech Origin and Evidence for Clonal Spread of Extensively Resistant Sequence Type 357 Expressing IMP-7 Metallo-β-Lactamase. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Additionally, the sporadic emergence of P. aeruginosa producing different carbapenemase types, associated with divergent or novel integrons, punctuated the ongoing evolution of these bacteria. ..
  78. Nicastro G, Candel A, Uhl M, Oregioni A, Hollingworth D, Backofen R, et al. Mechanism of β-actin mRNA Recognition by ZBP1. Cell Rep. 2017;18:1187-1199 pubmed publisher
    b>Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development...
  79. Palmer N, Goodarzi M, Langefeld C, Ziegler J, Norris J, Haffner S, et al. Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2008;57:1093-100 pubmed publisher
    ..We observe evidence that diabetes risk for CDKAL1, SLC30A8, IGF2BP2, and LOC387761 is specifically mediated through defects in insulin secretion. The mechanisms of other predisposing genes remain to be elucidated. ..
  80. Elcheva I, Tarapore R, Bhatia N, Spiegelman V. Overexpression of mRNA-binding protein CRD-BP in malignant melanomas. Oncogene. 2008;27:5069-74 pubmed publisher
    ..Knockdown of CRD-BP inhibits NF-kappaB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells. ..
  81. Elcheva I, Goswami S, Noubissi F, Spiegelman V. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell. 2009;35:240-6 pubmed publisher
    ..Here we demonstrate that CRD-BP prevents degradation of betaTrCP1 mRNA by attenuating its miR-183-dependent interaction with Ago2. ..
  82. Craig E, Weber J, Spiegelman V. Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia. J Cell Sci. 2012;125:5950-4 pubmed publisher
    ..This work also describes a previously unknown role for CRD-BP in the regulation of melanoma cell invasion and highlights the importance of the hypoxic microenvironment in determining cell fate. ..
  83. Stutz M, Ojaimi S, Allison C, Preston S, Arandjelovic P, Hildebrand J, et al. Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted. Cell Death Differ. 2018;25:951-965 pubmed publisher
    ..that Mtb infection of macrophages remodeled the intracellular signaling landscape by upregulating MLKL, TNFR1, and ZBP1, whilst downregulating cIAP1, thereby establishing a strong pro-necroptotic milieu...
  84. Rini J, Anbalagan M. IGF2BP1: a novel binding protein of p38 MAPK. Mol Cell Biochem. 2017;435:133-140 pubmed publisher
    ..Based on mass spectrometry data, here we report insulin-like growth factor-II binding protein 1 (IGF2BP1) as a novel interacting partner of p38 MAPK...
  85. Barnes M, van Rensburg G, Li W, Mehmood K, Mackedenski S, Chan C, et al. Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains. J Biol Chem. 2015;290:625-39 pubmed publisher
    ..The novel insights revealed in this study have important implications on the understanding of the oncogenic mechanism of CRD-BP as well as in the future design of inhibitors against CRD-BP function. ..
  86. Hammer N, Hansen T, Byskov A, Rajpert De Meyts E, Grøndahl M, Bredkjaer H, et al. Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. Reproduction. 2005;130:203-12 pubmed
    Insulin-like growth factor-II mRNA-binding proteins 1, 2 and 3 (IMP1, IMP2 and IMP3) belong to a family of RNA-binding proteins implicated in mRNA localization, turnover and translational control...
  87. Ganeff C, Chatel G, Munaut C, Frankenne F, Foidart J, Winkler R. The IGF system in in-vitro human decidualization. Mol Hum Reprod. 2009;15:27-38 pubmed publisher
    ..These results suggest that the IGF signalling pathway could play a crucial role in the functions of decidualized endometrial cells. ..
  88. Fakhraldeen S, Clark R, Roopra A, Chin E, Huang W, Castorino J, et al. Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells. J Biol Chem. 2015;290:13386-400 pubmed publisher
    CRD-BP/IGF2BP1 has been characterized as an "oncofetal" RNA binding protein typically highly expressed in embryonic tissues, suppressed in normal adult tissues, but induced in many tumor types...
  89. Craig E, Spiegelman V. Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents. Pigment Cell Melanoma Res. 2012;25:83-7 pubmed publisher
    We previously reported that malignant melanomas express high levels of the mRNA binding protein coding region determinant binding protein (CRD-BP)...
  90. Nielsen J, Adolph S, Rajpert De Meyts E, Lykke Andersen J, Koch G, Christiansen J, et al. Nuclear transit of human zipcode-binding protein IMP1. Biochem J. 2003;376:383-91 pubmed
    ..In the present study, we show that IMP1 is capable of translocating into nuclei of NIH 3T3 fibroblasts and its immunoreactivity is present in the nuclei of ..
  91. Qu Y, Pan S, Kang M, Dong R, Zhao J. MicroRNA-150 functions as a tumor suppressor in osteosarcoma by targeting IGF2BP1. Tumour Biol. 2016;37:5275-84 pubmed publisher
    ..Mechanistically, IGF2 mRNA-binding protein 1(IGF2BP1) was confirmed to act as a direct target of miR-150, and the IGF2BP1 mRNA expression was inversely correlated ..