IGF-IR

Summary

Gene Symbol: IGF-IR
Description: insulin like growth factor 1 receptor
Alias: CD221, IGFIR, IGFR, JTK13, insulin-like growth factor 1 receptor, IGF-I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2
Species: human
Products:     IGF-IR

Top Publications

  1. Tamimi R, Colditz G, Wang Y, Collins L, Hu R, Rosner B, et al. Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat. 2011;128:243-50 pubmed publisher
    ..Further studies to confirm these findings are necessary. ..
  2. Fox E, Miller T, Balko J, Kuba M, Sanchez V, Smith R, et al. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res. 2011;71:6773-84 pubmed publisher
    ..We conclude that therapeutic targeting of both InsR and IGF-IR should be more effective than targeting IGF-IR alone in abrogating resistance to endocrine therapy in breast cancer. ..
  3. Franks S, Campbell C, Barnett E, Siwicky M, Livingstone J, Cory S, et al. Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature. Oncogene. 2012;31:3298-309 pubmed publisher
    ..Therefore, this approach was utilized to classify the mammary tumors that develop in MTB-IGFIR transgenic mice...
  4. Gilam A, Edry L, Mamluk Morag E, Bar Ilan D, Avivi C, Golan D, et al. Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers. Breast Cancer Res Treat. 2013;138:753-60 pubmed publisher
    ..These findings support the hypothesis that a SNP located in igf-1r gene may alter miRNA regulation of IGF-1R, with a putative effect on BRCA1 penetrance and breast cancer risk. ..
  5. Deng H, Lin Y, Badin M, Vasilcanu D, Stromberg T, Jernberg Wiklund H, et al. Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9. Biochem Biophys Res Commun. 2011;404:667-71 pubmed publisher
    ..Over-accumulation of nIGF-1R may contribute to deregulated gene expression and therewith play a pathophysiological role in cancer cells. ..
  6. Medyouf H, Gusscott S, Wang H, Tseng J, Wai C, Nemirovsky O, et al. High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med. 2011;208:1809-22 pubmed publisher
  7. Liu B, Fan Z, Edgerton S, Yang X, Lind S, Thor A. Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle. 2011;10:2959-66 pubmed
    ..This action appears to be independent of mTOR signaling. Our findings provide a rationale to study the effects of metformin on patients with erbB2 positive tumors treated with trastuzumab, with or without resistance. ..
  8. Gest C, Mirshahi P, Li H, Pritchard L, Joimel U, Blot E, et al. Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets. Cancer Lett. 2012;317:207-17 pubmed publisher
    ..Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising. ..
  9. Alvino C, Ong S, McNeil K, Delaine C, Booker G, Wallace J, et al. Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II. PLoS ONE. 2011;6:e27488 pubmed publisher
    ..This study provides novel insight into the mechanism of receptor binding and activation by IGF-II, which may be important for the future development of inhibitors of its action for the treatment of cancer. ..

More Information

Publications80

  1. Doyle S, Donohoe C, Finn S, Howard J, Lithander F, Reynolds J, et al. IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity. Am J Gastroenterol. 2012;107:196-204 pubmed publisher
    ..These results indicate that the IGF-1 axis has a key role in malignant progression of esophageal cancer, and represents a plausible mechanism through which visceral obesity impacts on esophageal adenocarcinoma risk and tumor biology. ..
  2. Durfort T, Tkach M, Meschaninova M, Rivas M, Elizalde P, Venyaminova A, et al. Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model. PLoS ONE. 2012;7:e29213 pubmed publisher
    ..Interestingly, our work also suggests that crosstalk between IGF-I axis and antitumor immune response can mobilize proinflammatory cytokines. ..
  3. Asmane I, Watkin E, Alberti L, Duc A, Marec Berard P, Ray Coquard I, et al. Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. Eur J Cancer. 2012;48:3027-35 pubmed publisher
    ..Nuclear localisation of IGF-1R in tumour cells might be a hallmark of pathway activation. ..
  4. Bäck K, Islam R, Johansson G, Chisalita S, Arnqvist H. Insulin and IGF1 receptors in human cardiac microvascular endothelial cells: metabolic, mitogenic and anti-inflammatory effects. J Endocrinol. 2012;215:89-96 pubmed publisher
    ..TNF-? has a pronounced pro-inflammatory effect in HMVEC-Cs, which is not counteracted by insulin or IGF1. ..
  5. Ucar D, Kurenova E, Garrett T, Cance W, Nyberg C, Cox A, et al. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle. 2012;11:3250-9 pubmed publisher
    ..Our data suggest that the FAK-IGF-1R protein interaction is an important target, and disruption of this interaction with a novel small molecule (INT2-31) has potential anti-neoplastic therapeutic effects in human melanoma. ..
  6. Janku F, Huang H, Angelo L, Kurzrock R. A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal. Oncotarget. 2013;4:463-73 pubmed
    ..Collectively, these experiments suggest that IGF-1R, has kinase-independent biologic functions and provide a rationale for combining anti-IGF-1R antibodies or siRNA and IGF-1R small molecule inhibitors. ..
  7. Farhana L, Dawson M, Murshed F, Das J, Rishi A, Fontana J. Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. PLoS ONE. 2013;8:e61015 pubmed publisher
    ..Together these results implicate key roles for miR-150* and miR-630 and their targeting of IGF-1R to promote apoptosis in pancreatic cancer cells. ..
  8. Litzenburger B, Creighton C, Tsimelzon A, Chan B, Hilsenbeck S, Wang T, et al. High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clin Cancer Res. 2011;17:2314-27 pubmed publisher
    ..These studies provide a clear biological rationale to test anti-IGF-IR/InsR therapy in combination with chemotherapy in patients with TNBC. ..
  9. Yerushalmi R, Gelmon K, Leung S, Gao D, Cheang M, Pollak M, et al. Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes. Breast Cancer Res Treat. 2012;132:131-42 pubmed publisher
    ..Results may have relevance to the development of therapeutics targeting IGF-1R. ..
  10. Di Bartolo B, Schoppet M, Mattar M, Rachner T, Shanahan C, Kavurma M. Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification. Cardiovasc Res. 2011;91:537-45 pubmed publisher
    ..In contrast, high calcium leads to inhibition of IGF1R expression and activity to stimulate VSMC calcification further. ..
  11. Davison Z, de Blacquière G, Westley B, May F. Insulin-like growth factor-dependent proliferation and survival of triple-negative breast cancer cells: implications for therapy. Neoplasia. 2011;13:504-15 pubmed
  12. Vishwamitra D, Shi P, Wilson D, Manshouri R, Vega F, Schlette E, et al. Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma. Haematologica. 2011;96:871-80 pubmed publisher
    ..IGF-IR is up-regulated and frequently activated in mantle cell lymphoma. Our data suggest that IGF-IR could be a molecular target for the treatment of mantle cell lymphoma. ..
  13. Bhargava R, Beriwal S, McManus K, Dabbs D. Insulin-like growth factor receptor-1 (IGF-1R) expression in normal breast, proliferative breast lesions, and breast carcinoma. Appl Immunohistochem Mol Morphol. 2011;19:218-25 pubmed publisher
    ..The consistent presence of IGF-1R in ER+ tumors may explain the lower response rate to neoadjuvant chemotherapy in luminal tumors. ..
  14. Nakagawa M, Uramoto H, Oka S, Chikaishi Y, Iwanami T, Shimokawa H, et al. Clinical significance of IGF1R expression in non-small-cell lung cancer. Clin Lung Cancer. 2012;13:136-42 pubmed publisher
    ..However, in subgroup analysis, a significant correlation was not observed. IGF1R expression predicts postoperative recurrence in patients with AD, but not in those with non-AD of NSCLC. ..
  15. Lerman G, Avivi C, Mardoukh C, Barzilai A, Tessone A, Gradus B, et al. MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R. PLoS ONE. 2011;6:e20916 pubmed publisher
    ..We suggest that miR-99a is one of the regulators of the IGF-1R signaling pathway in keratinocytes. Activation of IGF1 signaling results in elevation of miR-99a which represses the expression of IGF-1R. ..
  16. Kikuchi R, Sonobe M, Kobayashi M, Ishikawa M, Kitamura J, Nakayama E, et al. Expression of IGF1R is associated with tumor differentiation and survival in patients with lung adenocarcinoma. Ann Surg Oncol. 2012;19 Suppl 3:S412-20 pubmed publisher
    ..2% versus 64.6% 5-year survival, P = 0.0084). The present study suggests the level of IGF1R expression to be a useful prognostic marker for patients with dedifferentiated lung adenocarcinoma. ..
  17. Fu P, Ibusuki M, Yamamoto Y, Hayashi M, Murakami K, Zheng S, et al. Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression. Breast Cancer Res Treat. 2011;130:307-17 pubmed publisher
    ..In particular, IGF1R mRNA expression appeared to be a good prognostic marker both in the entire cohort and in the luminal subtype group. These data may serve as background information for IGF1R-targeted therapy. ..
  18. Liang Z, Diepstra A, Xu C, Van Imhoff G, Plattel W, van den Berg A, et al. Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma. PLoS ONE. 2014;9:e87474 pubmed publisher
    ..In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines. ..
  19. Shi Z, Wang X, Qian X, Tao T, Wang L, Chen Q, et al. MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas. RNA. 2013;19:552-60 pubmed publisher
    ..Taken together, our results indicate that miR-181b functions in gliomas to suppress growth by targeting the IGF-1R oncogene and that miR-181b may serve as a novel therapeutic target for gliomas. ..
  20. Xu C, Xie D, Yu S, Yang X, He L, Yang J, et al. β-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma. Cancer Res. 2013;73:3181-9 pubmed publisher
  21. Fleuren E, Versleijen Jonkers Y, Heskamp S, Roeffen M, Bouwman W, Molkenboer Kuenen J, et al. The strength of small: improved targeting of insulin-like growth factor-1 receptor (IGF-1R) with F(ab')?-R1507 fragments in Ewing sarcomas. Eur J Cancer. 2013;49:2851-8 pubmed publisher
    ..This suggests that anti-IGF-1R therapies in ES and other tumours may be improved by using smaller therapeutic compounds, although further in vivo studies addressing this topic are warranted. ..
  22. Fujita M, Ieguchi K, Cedano Prieto D, Fong A, Wilkerson C, Chen J, et al. An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R. J Biol Chem. 2013;288:19593-603 pubmed publisher
    ..Our results are consistent with a model in which ternary complex formation is critical for IGF signaling. ..
  23. Fan G, Lin G, Lucito R, Tonks N. Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. J Biol Chem. 2013;288:24923-34 pubmed publisher
    ..These data reveal an important role for PTP1B as a negative regulator of BRK and IGF-1R? signaling in ovarian cancer cells. ..
  24. Galet C, Gray A, Said J, Castor B, Wan J, Beltran P, et al. Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts. Int J Mol Sci. 2013;14:13782-95 pubmed publisher
    ..In conclusion, whereas ganitumab therapy modestly affected 22Rv1 tumor growth, combining IGF-1R blockade with calorie restriction resulted in a significant decrease in final tumor weight and improved metabolic profile. ..
  25. Vazquez Martin A, Cufí S, Oliveras Ferraros C, Torres Garcia V, Corominas Faja B, Cuyàs E, et al. IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations. Sci Rep. 2013;3:2560 pubmed publisher
  26. Kim J, Kang M, Yoon Y, Kim H, Park J, Song S, et al. Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody. PLoS ONE. 2012;7:e33322 pubmed publisher
    ..The data suggest that the level of N-linked glycosylated IGF1R/IR heterodimeric receptor is highly associated with sensitivity to anti-IGF1R antibody in cancer cells. ..
  27. Sarfstein R, Pasmanik Chor M, Yeheskel A, Edry L, Shomron N, Warman N, et al. Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. J Biol Chem. 2012;287:2766-76 pubmed publisher
    ..The clinical implications of these findings and, in particular, the impact of IGF-IR/IR nuclear localization on targeted therapy require further investigation. ..
  28. Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, et al. Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res. 2011;13:R52 pubmed publisher
    ..Our data provide evidence that the IGF-1/IGF-1R signaling axis may play a causal role in antiestrogen resistance of breast cancer cells, despite continuous suppression of ER transcriptional function by antiestrogens. ..
  29. Kim T, Cho E, Paik S, Kim I. Hypoxia-induced SM22? in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy. FEBS Lett. 2012;586:303-9 pubmed publisher
    ..Moreover, SM22? overexpression enhances tumor cell growth and activates the IGF1R/PI3K/Akt pathway via direct interaction with IGF1R?. Our results suggest SM22? as a novel regulator of hypoxic survival pathway of A549 NSCLC cells. ..
  30. Zhao X, Dou W, He L, Liang S, Tie J, Liu C, et al. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene. 2013;32:1363-72 pubmed publisher
    ..The present study provides insight into the specific biological behavior of miR-7 in EMT and tumor metastasis. Targeting this novel miR-7/IGF1R/Snail axis would be helpful as a therapeutic approach to block GC metastasis. ..
  31. Guo S, Jiang C, Wang G, Li Y, Wang C, Guo X, et al. MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. Oncogene. 2013;32:1910-20 pubmed publisher
    ..Taken together, these results identify downregulation of miR-497 as an important mechanism of upregulation of IGF1-R in CRC cells that contributes to malignancy of CRC. ..
  32. Evdokimova V, Tognon C, Benatar T, Yang W, Krutikov K, Pollak M, et al. IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors. Sci Signal. 2012;5:ra92 pubmed publisher
    ..These results support a model whereby IGFBP7 binds to unoccupied IGF1R and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival. ..
  33. Zhang R, Xu G, Li Y, He L, Chen L, Wang G, et al. The role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma. J Int Med Res. 2013;41:1228-35 pubmed publisher
    ..IGF1 and its receptor may be activated before carcinogenesis, and may promote the growth and malignant transformation of adenomatous polyps. IGF1 and IGF1R may be useful biomarkers for evaluating the stage and risk of carcinogenesis. ..
  34. Bailyes E, Nave B, Soos M, Orr S, Hayward A, Siddle K. Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J. 1997;327 ( Pt 1):209-15 pubmed
    The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian tissues, and are known to be capable of heteromeric assembly as insulin/IGF hybrid receptors, in addition to ..
  35. Abuzzahab M, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, et al. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med. 2003;349:2211-22 pubmed
    ..Mutations in the IGF-IR gene that lead to abnormalities in the function or number of IGF-I receptors may also retard intrauterine and subsequent growth in humans. ..
  36. Laviola L, Perrini S, Belsanti G, Natalicchio A, Montrone C, Leonardini A, et al. Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling. Endocrinology. 2005;146:1498-505 pubmed
    ..The observed abnormalities in IGF-I signaling may contribute to altered fetal growth and development in human IUGR. ..
  37. Lewis D, Yi Q, Travers J, Spandau D. UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell. 2008;19:1346-53 pubmed publisher
    ..These data suggest one mechanism of keratinocyte resistance to UVB-induced carcinogenesis involves the induction of IGF-1R-dependent premature senescence. ..
  38. Lewis D, Spandau D. UVB-induced activation of NF-kappaB is regulated by the IGF-1R and dependent on p38 MAPK. J Invest Dermatol. 2008;128:1022-9 pubmed
    ..In the absence of ligand-activated IGF-1R, UVB irradiation leads to the induction of NF-kappaB p50:p50 homodimers and a p38-dependent increased susceptibility to apoptosis. ..
  39. Wang L, Schulz T, Sherrer E, Dauphin D, Shin S, Nelson A, et al. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood. 2007;110:4111-9 pubmed
    ..These studies identify previously unappreciated RTKs that support hESC proliferation and self-renewal, and provide a rationally designed medium for the growth and maintenance of pluripotent hESCs. ..
  40. Morgillo F, Woo J, Kim E, Hong W, Lee H. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res. 2006;66:10100-11 pubmed
    ..Our data suggest that enhanced synthesis of survivin protein mediated by the IGFR/EGFR heterodimer counteracts the antitumor action of erlotinib, indicating the needs of integration of IGF-IR-..
  41. Bauer T, Somcio R, Fan F, Liu W, Johnson M, Lesslie D, et al. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol Cancer Ther. 2006;5:1676-82 pubmed
    ..Elucidation of the signaling pathways that contribute to tumor progression and metastasis should provide a foundation for the development of targeted therapies for pancreatic carcinoma. ..
  42. Reidy D, Vakiani E, Fakih M, Saif M, Hecht J, Goodman Davis N, et al. Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer. J Clin Oncol. 2010;28:4240-6 pubmed publisher
    ..IMC-A12 alone or in combination with cetuximab was insufficient to warrant additional study in patients with colorectal cancer refractory to EGFR inhibitors. ..
  43. Ahlén J, Wejde J, Brosjo O, von Rosen A, Weng W, Girnita L, et al. Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma. Clin Cancer Res. 2005;11:206-16 pubmed
    ..Further elucidation of the role of IGF-1R and the IGF system in STS may both provide a basis for development of new prognostic tools in STS, as well as shed light on the basic mechanisms of the STS development. ..
  44. Kato H, Faria T, Stannard B, Roberts C, LeRoith D. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J Biol Chem. 1993;268:2655-61 pubmed
    ..Additionally, the effects of alpha IR-3 also require tyrosine kinase activity. ..
  45. Hunter R, Hers I. Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function. J Thromb Haemost. 2009;7:2123-30 pubmed publisher
    ..8). Insulin has minimal effects on platelet function, which can be explained by the relatively low insulin receptor expression levels resulting in the majority of insulin receptor subunits being expressed as insulin/IGF-1 hybrids. ..
  46. McElroy B, Powell J, McCarthy J. The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis. Biochem Biophys Res Commun. 2007;358:1136-41 pubmed
    ..This study suggests that the IGF-IR is a substrate for gamma-secretase and may mediate a function independent of its role as a receptor tyrosine kinase. ..
  47. Garcia J, Ahmadi A, Wonnacott A, Sutcliffe W, Nagga K, Soderkvist P, et al. Association of insulin-like growth factor-1 receptor polymorphism in dementia. Dement Geriatr Cogn Disord. 2006;22:439-44 pubmed
    ..5, CI 95% 0.99-2.2, p = 0.054). Our results suggest that the A allele of IGF-1R may be involved in the pathogenesis of VaD in females. ..
  48. Craparo A, O Neill T, Gustafson T. Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem. 1995;270:15639-43 pubmed
    ..IRS-1) and SHC become rapidly phosphorylated upon tyrosines after insulin-like growth factor I receptor (IGFIR) activation...
  49. Suh Y, Atzmon G, Cho M, Hwang D, Liu B, Leahy D, et al. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A. 2008;105:3438-42 pubmed publisher
    ..centenarians relative to controls that are associated with high serum IGFI levels and reduced activity of the IGFIR as measured in transformed lymphocytes...
  50. La Rocca G, Badin M, Shi B, Xu S, deAngelis T, Sepp Lorenzinoi L, et al. Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway. J Cell Physiol. 2009;220:485-91 pubmed publisher
    ..These and other results, taken together, indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145. ..
  51. Shelton J, Steelman L, White E, McCubrey J. Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle. 2004;3:372-9 pubmed
    ..These results demonstrate that the PI3K/Akt and Raf/MEK/ERK pathways are intimately involved in IGF-1R-mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. ..
  52. Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004;64:236-42 pubmed
    ..Our results open the possibility to use PPP or related compounds with inhibitory effects on IGF-1R as lead compounds in development of anticancer agents. ..
  53. Howard T, Algar E, Glatz J, Reeve A, Smith P. The insulin-like growth factor 1 receptor gene is normally biallelically expressed in human juvenile tissue and tumours. Hum Mol Genet. 1993;2:2089-92 pubmed
    ..The observed biallelic expression of the IGF1R gene in all but one patient strongly suggests that the human gene is not normally imprinted. ..
  54. He W, Craparo A, Zhu Y, O Neill T, Wang L, Pierce J, et al. Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2. J Biol Chem. 1996;271:11641-5 pubmed
    ..Our findings suggest the existence of a previously unidentified phosphotyrosine-dependent binding domain within the central region of IRS-2. ..
  55. Meng Z, Snyder R, Shrestha K, Miller D, Emanuel P, Blume S. Evidence for differential ribonucleoprotein complex assembly in vitro on the 5'-untranslated region of the human IGF-IR transcript. Mol Cell Endocrinol. 2003;200:127-40 pubmed
    ..Our in vitro results indicate that the IGF-IR 5'-UTR may exist in at least three distinct states, and we propose that interconversion between these states might take place in vivo and differentially alter IGF-IR transcript utilization. ..
  56. Douglas R, Naik V, Hwang C, Afifiyan N, Gianoukakis A, Sand D, et al. B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol. 2008;181:5768-74 pubmed
    ..02) in vitro while those from control donors failed to respond. These findings suggest a potentially important role for IGF-1R display by B lymphocytes in patients with GD in supporting their expansion and abnormal Ig production...
  57. Riedemann J, Sohail M, Macaulay V. Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells. Biochem Biophys Res Commun. 2007;355:700-6 pubmed
    ..These results suggest that the EGFR cannot compensate for IGF1R depletion, and are encouraging for the strategy of IGF1R targeting. ..
  58. Denley A, Bonython E, Booker G, Cosgrove L, Forbes B, Ward C, et al. Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR. Mol Endocrinol. 2004;18:2502-12 pubmed
    ..Activation of IGF-1R by the chimeras reflected their binding affinities whereas the phosphorylation of the two IR isoforms was more complex. ..
  59. Shahrabani Gargir L, Pandita T, Werner H. Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1. Endocrinology. 2004;145:5679-87 pubmed
    ..Deregulated expression of the IGF-IR gene after ionizing radiation may be linked to genomic instability and enhanced transforming capacity. ..
  60. Eckstein N, Servan K, Hildebrandt B, Pölitz A, von Jonquieres G, Wolf Kümmeth S, et al. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 2009;69:2996-3003 pubmed publisher
    ..We conclude that targeting the IGF-IR and the PI3K pathways is a promising new strategy to treat cisplatin-resistant ovarian carcinomas. ..
  61. Tsui S, Naik V, Hoa N, Hwang C, Afifiyan N, Sinha Hikim A, et al. Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. J Immunol. 2008;181:4397-405 pubmed
  62. Bäck K, Arnqvist H. Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes. Growth Horm IGF Res. 2009;19:101-11 pubmed publisher
    ..DNA synthesis was increased by insulin and IGF-I at 10nM. In conclusion, both IR and IGF-IR are present in human preadipocytes and adipocytes. Differentiation is characterized by an increased IR/IGF-IR ratio. ..
  63. Lloret M, Lara P, Bordon E, Rey A, Falcón O, Apolinario R, et al. MVP expression is related to IGF1-R in cervical carcinoma patients treated by radiochemotherapy. Gynecol Oncol. 2008;110:304-7 pubmed publisher
    ..007) in patients achieving a complete response. MVP and IGF-1R expression were related in clinical cervical tumours and confer reduced long-term local control in patients who achieved clinical complete response to radiochemotherapy. ..
  64. Mohseni Zadeh S, Binoux M. Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action. Endocrinology. 1997;138:5645-8 pubmed
    ..we used a fibroblast cell line to investigate the possibility of an interaction with the type 1 IGF receptor (IGFR-1)...
  65. Peiro G, Adrover E, Sánchez Tejada L, Lerma E, Planelles M, Sanchez Paya J, et al. Increased insulin-like growth factor-1 receptor mRNA expression predicts poor survival in immunophenotypes of early breast carcinoma. Mod Pathol. 2011;24:201-8 pubmed publisher
    ..Our results highlight the biological and clinical relevance of IGF1R in early breast carcinoma subtypes, and provide knowledge to assist in treatment decision. ..
  66. Morrione A, Valentinis B, Li S, Ooi J, Margolis B, Baserga R. Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res. 1996;56:3165-7 pubmed
    ..Grb10 coprecipitates with the IGF-IR in cell lysates and is probably involved in the regulation of its activity. ..
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