IFNA1

Summary

Gene Symbol: IFNA1
Description: interferon alpha 1
Alias: IFL, IFN, IFN-ALPHA, IFN-alphaD, IFNA13, IFNA@, interferon alpha-1/13, IFN-alpha 1b, IFN-alpha-1/13, interferon alpha 1b, interferon alpha-D, interferon-alpha1, leIF D
Species: human
Products:     IFNA1

Top Publications

  1. Uze G, Di Marco S, Mouchel Vielh E, Monneron D, Bandu M, Horisberger M, et al. Domains of interaction between alpha interferon and its receptor components. J Mol Biol. 1994;243:245-57 pubmed
    ..and alpha2 and alpha8 on mouse cells are partially relieved by the expression of the bovine (Bo) or human (Hu) IFN alpha/beta receptor (IFNAR) component in these cells...
  2. Gurney K, Colantonio A, Blom B, Spits H, Uittenbogaart C. Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection. J Immunol. 2004;173:7269-76 pubmed
    Plasmacytoid dendritic cells (pDC) are the principal producers of IFN-alpha in response to viral infection. Because pDC are present in the thymus, we investigated the consequences of HIV-1-induced IFN-alpha production by thymic pDC...
  3. Asokan R, Hua J, Young K, Gould H, Hannan J, Kraus D, et al. Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus. J Immunol. 2006;177:383-94 pubmed
    ..ligands, C3d/iC3b, EBV-gp350, and CD23, a previous study has identified CR2 as a potential receptor for IFN-alpha...
  4. Martinelli E, Cicala C, Van Ryk D, Goode D, Macleod K, Arthos J, et al. HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2007;104:3396-401 pubmed
  5. Walsh R, Kong S, Yao Y, Jallal B, Kiener P, Pinkus J, et al. Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum. 2007;56:3784-92 pubmed
    ..Although PM and IBM have been modeled as having similar immunologic processes occurring within muscle, there are substantial differences in the expression of IFNalpha/beta-inducible genes in blood in these diseases. ..
  6. Genin P, Vaccaro A, Civas A. The role of differential expression of human interferon--a genes in antiviral immunity. Cytokine Growth Factor Rev. 2009;20:283-95 pubmed publisher
    ..describing how these factors regulate the temporal and quantitative differences in the expression of the multigenic IFN-A family...
  7. Kimura T, Hashimoto I, Nishizawa M, Ito S, Yamada H. Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-? 1 mRNA. Med Mol Morphol. 2010;43:145-57 pubmed publisher
    ..reported the chromosome region maintenance 1 (CRM1)-dependent nuclear export of intron-less human interferon-?1 (IFN-?1) mRNA, which encodes a main effecter of host innate immunity...
  8. Liao A, Salajegheh M, Nazareno R, Kagan J, Jubin R, Greenberg S. Interferon ? is associated with type 1 interferon-inducible gene expression in dermatomyositis. Ann Rheum Dis. 2011;70:831-6 pubmed publisher
    To determine whether type 1 interferon (IFN) proteins in blood are associated with downstream type 1 IFN-inducible gene expression in blood from patients with myositis...
  9. Capuron L, Pagnoni G, Drake D, Woolwine B, Spivey J, Crowe R, et al. Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration. Arch Gen Psychiatry. 2012;69:1044-53 pubmed publisher

More Information

Publications116 found, 100 shown here

  1. Henco K, Brosius J, Fujisawa A, Fujisawa J, Haynes J, Hochstadt J, et al. Structural relationship of human interferon alpha genes and pseudogenes. J Mol Biol. 1985;185:227-60 pubmed
    We have isolated and characterized DNA segments containing IFN-alpha-related sequences from human lambda and cosmid clone banks...
  2. Nagata S, Mantei N, Weissmann C. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature. 1980;287:401-8 pubmed
    The 12 interferon (IFN)-related sequences detected in a human gene bank fall into not less than eight distinct classes, indicating that there are at least eight IFN-related genes...
  3. Nyman T, Tölö H, Parkkinen J, Kalkkinen N. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. Biochem J. 1998;329 ( Pt 2):295-302 pubmed
    The human interferon-alpha (IFN-alpha) family is encoded by 13 different functional genes, and including all cloned sequence variants there are 28 potential IFN-alpha proteins...
  4. Schmidt B, Ashlock B, Foster H, Fujimura S, Levy J. HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration. Virology. 2005;343:256-66 pubmed
    Plasmacytoid dendritic cells (PDC), natural type-1 interferon (IFN) producing cells, could play a role in the innate anti-HIV immune response. Previous reports indicated that PDC IFN production is induced by HIV...
  5. Peng G, Lei K, Jin W, Greenwell Wild T, Wahl S. Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. J Exp Med. 2006;203:41-6 pubmed
    ..We identify interferon (IFN)-alpha as a potent inducer of APOBEC3G to override HIV Vif neutralization of APOBEC3 proteins that pose a threat to ..
  6. Mavragani C, Niewold T, Moutsopoulos N, Pillemer S, Wahl S, Crow M. Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept. Arthritis Rheum. 2007;56:3995-4004 pubmed
    ..etanercept resulted in a dose-dependent increase in the expression of IFNalpha and the IFNalpha-inducible genes IFN-induced protein with tetratricopeptide repeats 1 and BAFF...
  7. Neil S, Zang T, Bieniasz P. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature. 2008;451:425-30 pubmed publisher
    ..Vpu co-localized with CD317 and inhibited these effects. Inhibition of Vpu function and consequent mobilization of tetherin's antiviral activity is a potential therapeutic strategy in HIV/AIDS. ..
  8. Hirankarn N, Tangwattanachuleeporn M, Wongpiyabovorn J, Wongchinsri J, Avihingsanon Y. Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus. Tissue Antigens. 2008;72:588-92 pubmed publisher
    ..05). This is the first report of positive association of IFNA gene in SLE, especially the role of specific subtypes IFNA1 and IFNA5.
  9. Welzel T, Morgan T, Bonkovsky H, Naishadham D, Pfeiffer R, Wright E, et al. Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2009;49:1847-58 pubmed publisher
    Combination treatment with pegylated-interferon-alpha (PEG IFN-alpha) and ribavirin, the current recommended therapy for chronic hepatitis C virus (HCV) infection, results in a sustained virological response (SVR) in only about half of ..
  10. Salloum R, Franek B, Kariuki S, Rhee L, Mikolaitis R, Jolly M, et al. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. Arthritis Rheum. 2010;62:553-61 pubmed publisher
    ..Our findings indicate that IRF7/PHRF1 variants in combination with SLE-associated autoantibodies result in higher serum levels of IFNalpha, providing a biologic relevance for this locus at the protein level in human SLE in vivo. ..
  11. Shrestha S, Wershil B, Sarwark J, Niewold T, Philipp T, Pachman L. Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells. Arthritis Rheum. 2010;62:2813-22 pubmed publisher
    ..Myxovirus resistance protein A (MxA) staining indicated active type I interferon (IFN) signaling; positive staining was scored semiquantitatively and analyzed using the Mann-Whitney U test...
  12. O Brien M, Manches O, Sabado R, Baranda S, Wang Y, Marie I, et al. Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-?-producing and partially matured phenotype. J Clin Invest. 2011;121:1088-101 pubmed publisher
    Plasmacytoid DCs (pDCs) are innate immune cells that are specialized to produce IFN-? and to activate adaptive immune responses...
  13. Khorooshi R, Wlodarczyk A, Asgari N, Owens T. Neuromyelitis optica-like pathology is dependent on type I interferon response. Exp Neurol. 2013;247:744-7 pubmed publisher
    ..Loss of aquaporin-4 and glial fibrillary acidic protein was reduced in type I interferon receptor deficient mice brain. Our findings suggest that type I interferon signaling contributes to neuromyelitis optica pathogenesis. ..
  14. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George S, Ahrorov A, et al. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018;154:1405-1420.e2 pubmed publisher
    ..HT-29 cells were incubated with cell stressors such as DTT, IFN, and adherent-invasive E coli or control agents; cells were analyzed by immunoblots and quantitative polymerase ..
  15. Zhao X, Sun P, Li G, Yi R, Qian Y, Park K. Polyphenols in Kuding tea help prevent HCl/ethanol-induced gastric injury in mice. Food Funct. 2018;9:1713-1725 pubmed publisher
    ..HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-? (TNF-?), interferon-? (IFN-?), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and ..
  16. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..RI caused an increase of IL-1, IL-2, IL-3, IL-5, IL-6, IL-12, IL-13, IL-15, IL-17A, IL-18, G-CSF, CM-CSF, eotaxin, IFN-?, MCP-1, MIP, RANTES, and TNF-?, which were all increased by hemorrhage alone, except IL-9, IL-17A, and MCP-1...
  17. Zhang L, Li Y, Guan C, Tian S, Lv X, Li J, et al. Therapeutic effect of human umbilical cord-derived mesenchymal stem cells on injured rat endometrium during its chronic phase. Stem Cell Res Ther. 2018;9:36 pubmed publisher
    ..Proinflammatory factors interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-2 were significantly downregulated in the rats ..
  18. Krakauer T. Staphylococcal Superantigens: Pyrogenic Toxins Induce Toxic Shock. Toxins (Basel). 2019;11: pubmed publisher
    ..Proinflammatory cytokines, tumor necrosis factor α, interleukin 1 (IL-1), IL-2, interferon γ (IFNγ), and macrophage chemoattractant protein 1 elicit fever, inflammation, multiple organ injury, hypotension, and ..
  19. Qian Y, Zhang J, Fu X, Yi R, Sun P, Zou M, et al. Preventive Effect of Raw Liubao Tea Polyphenols on Mouse Gastric Injuries Induced by HCl/Ethanol via Anti-Oxidative Stress. Molecules. 2018;23: pubmed publisher
    ..decrease the serum levels of IL-6 (interleukin-6), IL-12 (interleukin-12), TNF-α (tumor necrosis factor-α), and IFN-γ (interferon-γ) in mice with gastric injuries...
  20. Bertoletti A, Tan A, Koh S. T-cell therapy for chronic viral hepatitis. Cytotherapy. 2017;19:1317-1324 pubmed publisher
    ..HCV is able to activate in the infected host a classical type I interferon (IFN)-mediated innate response [3], whereas HBV generally escapes innate immune recognition and does not activate type I ..
  21. Kurose T, Hashimoto M, Ozawa J, Kawamata S. Analysis of Gene Expression in Experimental Pressure Ulcers in the Rat with Special Reference to Inflammatory Cytokines. PLoS ONE. 2015;10:e0132622 pubmed publisher
    ..PCR showed the up-regulation of granulocyte-macrophage colony stimulating factor (GM-CSF), interferon γ (IFN-γ), interleukin 1β (IL-1β), interleukin 1 receptor antagonist gene (IL1Ra), interleukin 6 (IL-6), ..
  22. Chaiworapongsa T, Romero R, Gotsch F, Kusanovic J, Mittal P, Kim S, et al. Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma. J Matern Fetal Neonatal Med. 2010;23:167-78 pubmed
    ..concentrations of interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, interferon (IFN)-gamma, granulocyte macrophage colony stimulating factor, and tumor necrosis factor (TNF) were also determined ..
  23. Suo H, Zhao X, Qian Y, Sun P, Zhu K, Li J, et al. Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects. Nutrients. 2016;8:155 pubmed publisher
    ..The cytokine IL-6 (interleukin 6), IL-12 (interleukin 12), TNF-α (tumor necrosis factor-α) and IFN-γ (interferon-γ) serum levels were decreased after the LF-Suo treatment...
  24. Marzocco S, Fazeli G, Di Micco L, Autore G, Adesso S, Dal Piaz F, et al. Supplementation of Short-Chain Fatty Acid, Sodium Propionate, in Patients on Maintenance Hemodialysis: Beneficial Effects on Inflammatory Parameters and Gut-Derived Uremic Toxins, A Pilot Study (PLAN Study). J Clin Med. 2018;7: pubmed publisher
    ..The inflammatory parameters IL-6 and IFN-gamma showed a mild non-significant reduction and the anti-inflammatory cytokine IL-10 increased significantly (+71%..
  25. Papadogiannakis E, Koutinas A. Cutaneous immune mechanisms in canine leishmaniosis due to Leishmania infantum. Vet Immunol Immunopathol. 2015;163:94-102 pubmed publisher
    ..a significant population of cellular immunity in CanL since they outnumber CD4+ cells in the dermis, producing IFN-γ in sub clinically infected dogs and high levels of IL-4 in dogs with clinical leishmaniosis...
  26. Pan Y, Long X, Yi R, Zhao X. Polyphenols in Liubao Tea Can Prevent CCl₄-Induced Hepatic Damage in Mice through Its Antioxidant Capacities. Nutrients. 2018;10: pubmed publisher
    ..levels of interleukin-6 (IL-6), interleukin-12 (IL-12), tumor necrosis factor- α (TNF- α ), and interferon- γ (IFN- γ ) cytokines in mice with liver injury...
  27. Dai S, Zhuo M, Song L, Chen X, Yu Y, Zang G, et al. Lentiviral vector encoding ubiquitinated hepatitis B core antigen induces potent cellular immune responses and therapeutic immunity in HBV transgenic mice. Immunobiology. 2016;221:813-21 pubmed publisher
    ..that immunization with LV-Ub-HBcAg promoted the secretion of cytokines interleukin-2 (IL-2), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), generated remarkably high percentages of IFN-γ-secreting CD8(+) ..
  28. Beckett E, Phipps S, Starkey M, Horvat J, Beagley K, Foster P, et al. TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life. PLoS ONE. 2012;7:e39460 pubmed publisher
    ..Wt mice also had effective production of interferon (IFN)γ in the lymph nodes and lung, and proliferation of lymph node T-cells...
  29. Chong W, van Panhuys N, Chen J, Silver P, Jittayasothorn Y, Mattapallil M, et al. NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis. J Exp Med. 2015;212:1739-52 pubmed publisher
    b>IFN-γ is a pathogenic cytokine involved in inflammation. Paradoxically, its deficiency exacerbates experimental autoimmune encephalomyelitis, uveitis, and arthritis...
  30. Li D, Li H, Fu H, Niu K, Guo Y, Guo C, et al. Aire-Overexpressing Dendritic Cells Induce Peripheral CD4⁺ T Cell Tolerance. Int J Mol Sci. 2015;17: pubmed publisher
    ..Furthermore, following insulin stimulation, Aire cells decreased the number of CD4⁺ IFN-γ⁺ T cells in both STZ-T1D and WT mouse-derived splenocytes and reduced the expression levels of TCR ..
  31. Vavrova K, Vrabcová P, Filipp D, Bartunkova J, Horvath R. Generation of T cell effectors using tumor cell-loaded dendritic cells for adoptive T cell therapy. Med Oncol. 2016;33:136 pubmed
    ..The majority of both CD4+ and CD8+ IFN-? producing cells were CD62L, CCR7 and CD57 negative but CD28 and CD27 positive, indicating an early antigen ..
  32. Park E, Park S, Cho I, Kim B, Schuller Levis G. A Novel Cysteine Sulfinic Acid Decarboxylase Knock-Out Mouse: Immune Function (II). Adv Exp Med Biol. 2017;975 Pt 1:449-460 pubmed publisher
    ..In this study, we have examined innate immunity using macrophage activation with LPS or/and IFN-? and polymorphonuclear leukocytes (PMN) activation with phorbol myristate acetate (PMA)...
  33. Wang X, Che Y, Chen B, Zhang Y, Nakagawa M, Wang X. Evaluation of immune responses induced by a novel human papillomavirus type 16 E7 peptide-based vaccine with Candida skin test reagent as an adjuvant in C57BL/6 mice. Int Immunopharmacol. 2018;56:249-260 pubmed publisher
    ..It is interesting that Candida alone induced a significant polarization of Th1 response an production of IFN-γ, which indicated Candida alone may be used as a potential immunotherapeutic reagent not only for HPV-associated ..
  34. Yan Q, Liu Q, Li M, Li F, Zhu B, Wang J, et al. Molecular cloning, characterization and expression analysis of woodchuck retinoic acid-inducible gene I. J Huazhong Univ Sci Technolog Med Sci. 2016;36:335-343 pubmed publisher
    ..g., interferon-? (IFN-?). Innate immune response to hepatitis B virus (HBV) plays a pivotal role in viral clearance and persistence...
  35. Wang J, Fu X, Zhang D, Yu L, Li N, Lu Z, et al. ChAT-positive neurons participate in subventricular zone neurogenesis after middle cerebral artery occlusion in mice. Behav Brain Res. 2017;316:145-151 pubmed publisher
    ..Neither atropine nor donepezil affected peri-infarct microglial activation or serum concentrations of TNF-?, IFN-?, or TGF-? on day 7 after MCAO...
  36. Akoumianaki T, Chamilos G. DAPK1 Keeps the Peace in Antifungal Inflammation. Cell Host Microbe. 2016;20:695-697 pubmed publisher
    ..In this issue of Cell Host & Microbe, Oikonomou et al. (2016) identify a molecular link between IFN-?/DAPK1 signaling, the proteosomal degradation pathway, and LAP that is critical for dampening Aspergillus-..
  37. Wang J, Feng Y, Wang C, Zheng F, Hassan B, Zhi L, et al. Genome-wide analysis of an avirulent strain that induces protective immunity against challenge with virulent Streptococcus suis serotype 2. BMC Microbiol. 2017;17:67 pubmed publisher
    ..Piglets vaccinated with the avirulent strain, 05HAS68, had increased TNF-? and IFN-? levels in the peripheral blood and were fully protected from challenge infection with the most virulent S...
  38. Kim J, Park M, Nikapitiya C, Kim T, Uddin M, Lee H, et al. FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1. PLoS Pathog. 2017;13:e1006398 pubmed publisher
    ..highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production...
  39. Araz F, Durand C, Gürakar A. New modalities in the treatment of HCV in pre and post - transplantation setting. Turk J Gastroenterol. 2015;26:204-13 pubmed publisher
    ..Interferon (IFN)-based regimens have achieved low Sustained Virological Rates (SVR) in this setting and are associated with a high ..
  40. Narayanan S, Townsend K, Macharia T, Majid A, Nelson A, Redfield R, et al. Favorable adverse event profile of sofosbuvir/ribavirin compared to boceprevir/interferon/ribavirin for treatment of hepatitis C. Hepatol Int. 2014;8:560-6 pubmed publisher
    ..The aim of this study was to evaluate the AEs observed with BOC triple therapy in comparison to IFN-free sofosbuvir/ribavirin (SOF/RBV) therapy in HCV monoinfected, genotype-1 (GT-1) individuals...
  41. Motawi T, El Boghdady N, El Sayed A, Helmy H. Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma. Tumour Biol. 2016;37:1617-25 pubmed publisher
    ..This study was conducted to evaluate the effects of PEGylated interferon-α2a (PEG-IFN-α2a) and 5-fluorouracil (5-FU) on the expression of CSC markers and on specific pathways that contribute to the ..
  42. Bergallo M, Loiacono E, Gambarino S, Vergano L, Tavormina P. Standard and immunoproteasomes expression in paediatric tonsillectomy patients. Minerva Pediatr. 2016;: pubmed
    Pro-inflammatory cytokines including TNF? and IFN-?, play an important role during the recurrent tonsillitis illness and proteasome and immunoproteasome stimulation...
  43. Pranzatelli M, Tate E, Allison T. Case-control, exploratory study of cerebrospinal fluid chemokines/cytokines and lymphocyte subsets in childhood Tourette syndrome with positive streptococcal markers. Cytokine. 2017;96:49-53 pubmed publisher
    ..the frequency of CSF B and T cell subsets or NK cells; the proportion of intracellularly-stained T helper type 1 (IFN-γ) or type 2 (IL-4) cells; the concentrations of B cell chemoattractants CXCL13, CXCL10; the B cell ..
  44. Luo X, Xiong X, Shao Q, Xiang T, Li L, Yin X, et al. The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation. Oncotarget. 2017;8:48875-48888 pubmed publisher
    Interferon (IFN) regulatory factor 8 is encoded by a novel candidate tumor suppressor gene (IRF8), its promotor is frequently methylated in multiple cancers...
  45. Braun J, Ruchel J, Manzoni A, Abdalla F, Casalli E, Castilhos L, et al. Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. Mol Cell Biochem. 2018;444:63-75 pubmed publisher
    ..The IFN-? and IL-4 cytokines were increased in the hyperlipidemic group when compared with control group, and decreased ..
  46. Han S, Melichar H, Coombes J, Chan S, Koshy A, Boothroyd J, et al. Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii. Immunol Cell Biol. 2014;92:872-81 pubmed publisher
    The classic anti-viral cytokine interferon (IFN)-? can be induced during parasitic infection, but relatively little is know about the cell types and signaling pathways involved...
  47. Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, et al. Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps. Allergol Int. 2016;65:96-102 pubmed publisher
    ..of staphylococcal enterotoxin B (SEB), following which the levels of IL-5, IL-10, IL-13, IL-17A and interferon (IFN)-γ in the supernatant were measured...
  48. Theeten H, Matheï C, Peeters K, Ogunjimi B, Goossens H, Ieven M, et al. Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly. Viral Immunol. 2016;29:169-75 pubmed publisher
    ..Here we first aimed to measure influenza-specific cellular immunity using granzyme B (GrzB) and interferon-gamma (IFN-γ)-ELISpot...
  49. Bottero D, Gaillard M, Zurita E, Moreno G, Martinez D, Bartel E, et al. Characterization of the immune response induced by pertussis OMVs-based vaccine. Vaccine. 2016;34:3303-9 pubmed publisher
    ..Stimulation of splenocytes from immunized mice evidenced the presence of IFN-? and IL-17-producing cells, indicated that OMVs induces both Th1 and Th17 response...
  50. Megahed A, Salem N, Fathy A, Barakat T, Alsayed M, Mabood S, et al. Pegylated interferon ?/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection. World J Pediatr. 2017;13:346-352 pubmed publisher
    ..a relative paucity of data in children, especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV)...
  51. Xie Y, Gao J, Wu Y, Tang P, Hide G, Lai D, et al. Recombinant ?-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. Parasit Vectors. 2017;10:83 pubmed publisher
    ..Our results also revealed a statistically significant increase in splenocyte proliferation and related cytokine (IFN-?, IL-6, IL-17A and IL-10) production after repeated stimulation with the corresponding antigens in vitro...
  52. Sarathy V, White M, Li L, Kaiser J, Campbell G, Milligan G, et al. Characterization of a murine model of non-lethal, symptomatic dengue virus infection. Sci Rep. 2018;8:4900 pubmed publisher
    ..partially remedied with characterization of lethal DENV-2 infection in immunocompromised AG129 mice (deficient in IFN-α/β/γ receptors)...
  53. Hu W, Jain A, Gao Y, Dozmorov I, Mandraju R, Wakeland E, et al. Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation. Proc Natl Acad Sci U S A. 2015;112:13994-9 pubmed publisher
    ..TLR4 and TLR3 can both use the Toll-IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-dependent signaling pathway leading to IFN regulatory factor 3 (IRF3) activation and induction of IFN-Î..
  54. Cortés R, Ivorra C, Martínez Hervás S, Pedro T, González Albert V, Artero A, et al. Postprandial Changes in Chemokines Related to Early Atherosclerotic Processes in Familial Hypercholesterolemic Subjects: A Preliminary Study. Arch Med Res. 2016;47:33-9 pubmed publisher
    ..In the fasting state MIP-1β, MIP-1α, IP-10, IFN-γ, MCP-1, and IL-8 were significantly increased in the FH group compared to the healthy controls (p <0.05)...
  55. Lage D, Martins V, Duarte M, Costa L, Tavares G, Ramos F, et al. Cross-protective efficacy of Leishmania infantum LiHyD protein against tegumentary leishmaniasis caused by Leishmania major and Leishmania braziliensis species. Acta Trop. 2016;158:220-230 pubmed publisher
    ..of rLiHyD/saponin vaccine was evaluated, and the results showed that immunized mice produced high levels of IFN-γ, IL-12 and GM-CSF after in vitro stimulation with rLiHyD, as well as by using L. major or L...
  56. Zhang L, Xin Q, Zhu S, Wan W, Wang W, Xiao G. Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus. J Virol. 2016;90:10259-10270 pubmed publisher
    ..of pathogenic arenaviruses can disrupt RLR/MAVS signaling, thus inhibiting production of type I interferon (IFN-I). However, recent studies have shown elevated IFN-I levels in certain arenavirus-infected cells...
  57. Inui M, Sugahara Tobinai A, Fujii H, Itoh Nakadai A, Fukuyama H, Kurosaki T, et al. Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE. Int Immunol. 2016;28:597-604 pubmed publisher
    ..upon activation of memory B cells in vitro B4 expression was found to be induced efficiently by IL-2, while IFN-? effectively induced B4+ PBs/PCs in vitro Utilizing the elevated B4 will support opening a new avenue ..
  58. Hua Y, Jiao Y, Ma Y, Peng X, Fu Y, Zhang X, et al. Enhanced humoral and CD8+ T cell immunity in mice vaccinated by DNA vaccine against human respiratory syncytial virus through targeting the encoded F protein to dendritic cells. Int Immunopharmacol. 2017;46:62-69 pubmed publisher
    ..Compared with pVAX1/scISOF, both the ratio of IgG2a/IgG1, >1, and the enhanced IFN-? cytokine were induced in mice following pVAX1/scDECF immunization, which exhibited a Th1 dominant response in ..
  59. Cytlak U, Resteu A, Bogaert D, Kuehn H, Altmann T, Gennery A, et al. Ikaros family zinc finger 1 regulates dendritic cell development and function in humans. Nat Commun. 2018;9:1239 pubmed publisher
    ..DC and monocytes from patients with IKZF1 deficiency or lenalidomide-treated cultures secrete less IFN-α, TNF and IL-12...
  60. Ma H, Zhang S, Shi D, Mao Y, Cui J. MicroRNA-26a Promotes Regulatory T cells and Suppresses Autoimmune Diabetes in Mice. Inflammation. 2016;39:1-9 pubmed publisher
    ..pre-Mir-26a (LV-26a)-treated mice had significantly longer normoglycemic time and lower frequency of autoreactive IFN-γ-producing CD4(+) cells compared with an empty lentiviral vector (LV-Con)-treated non-obese diabetic (NOD) mice...
  61. Parsons E, Epstein J, Sedegah M, Villasante E, Stewart A. Decrease in circulating CD25(hi)Foxp3(+) regulatory T cells following vaccination with the candidate malaria vaccine RTS,S. Vaccine. 2016;34:4618-4625 pubmed publisher
    ..correlation was observed between the frequency of Plasmodium falciparum circumsporozoite protein (PfCSP)-specific IFN-? and PfCSP-specific IL-10, as well as an inverse correlation between IL-10 induced by Hepatitis B surface antigen, ..
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    ..Type I IFNs suppressed innate immune cell function and parasitic-specific CD4+ T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells...
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    ..CD11b and Ly6G cells in the fibrotic liver, related to an increment of anti-fibrotic cytokines (IL-10, IL-13, IFN-? and HGF) and reduction of pro-inflammatory cytokines (IL-17A and IL-6)...
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    ..of the study was to correlate the effects of host cytokine single nucleotide polymorphisms of TNF-α (-308 A/G) and IFN-γ (+874 A/T) in spontaneous or IFN induced treatment response in the HCV infected thalassemic individuals...
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    ..Accordingly, transcription is initiated from multiple sites within a 100-nucleotide window. An IFN regulatory factor 1 (IRF1)/IRF2 binding site is located in this region and is involved in both basal and IRF1-..
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    b>IFN-? and IL-4 induce Th1 and Th2 responses, respectively, and often display antagonistic actions against each other...
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    ..2DL3+/- 3DL1+/- populations and analysed all possible combinations of interferon (IFN)-?, CCL4 and CD107a functional subsets responding to iCD4 cells...
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