Gene Symbol: IFITM3
Description: interferon induced transmembrane protein 3
Alias: 1-8U, DSPA2b, IP15, interferon-induced transmembrane protein 3, dispanin subfamily A member 2b, interferon-inducible protein 1-8U
Species: human
Products:     IFITM3

Top Publications

  1. Lewin A, Reid L, McMahon M, Stark G, Kerr I. Molecular analysis of a human interferon-inducible gene family. Eur J Biochem. 1991;199:417-23 pubmed
    ..They presumably reflect differences in the interaction of the ISREs with the various interferon-inducible and constitutive factors that govern the interferon response. ..
  2. Jia R, Xu F, Qian J, Yao Y, Miao C, Zheng Y, et al. Identification of an endocytic signal essential for the antiviral action of IFITM3. Cell Microbiol. 2014;16:1080-93 pubmed publisher
    ..Localization to these endocytic vesicles is essential for IFITM3 to interfere with the cytosolic entry of pH-dependent viruses...
  3. Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, et al. Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A. 2014;111:769-74 pubmed publisher
    ..Furthermore, patients with the rs12252-C/C IFN-induced transmembrane protein-3 (IFITM3) genotype had more rapid disease progression and were less likely to survive...
  4. Cuddapah S, Cui K, Zhao K. Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates activation of IFITM3 gene by BRGl. FEBS Lett. 2008;582:391-7 pubmed publisher
    ..We show that the BAF complex-mediated induction of IFITM3 is dependent on binding of the transcriptional enhancer factor 1 (TEF-1/TEAD1) to the M-CAT like elements of its ..
  5. Zhang Y, Zhao Y, Li N, Peng Y, Giannoulatou E, Jin R, et al. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun. 2013;4:1418 pubmed publisher
    ..4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent. ..
  6. Tanaka S, Yamaguchi Y, Tsoi B, Lickert H, Tam P. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev Cell. 2005;9:745-56 pubmed
    ..In contrast, Ifitm3, which is expressed in migratory PGCs, is sufficient to confer autonomous PGC-like homing properties to somatic ..
  7. John S, Chin C, Perreira J, Feeley E, Aker A, Savidis G, et al. The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol. 2013;87:7837-52 pubmed publisher
    The interferon-induced transmembrane protein 3 (IFITM3) gene is an interferon-stimulated gene that inhibits the replication of multiple pathogenic viruses in vitro and in vivo...
  8. Mudhasani R, Tran J, Retterer C, Radoshitzky S, Kota K, Altamura L, et al. IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus. J Virol. 2013;87:8451-64 pubmed publisher
    ..Collectively, our data provide new insights into the possible mechanisms by which the IFITM family members restrict distinct viruses. ..
  9. Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
    ..of IFITM-mediated restriction: compared with IAV, the entry processes of MARV and EBOV were less restricted by IFITM3, but more restricted by IFITM1...

More Information


  1. Chan Y, Huang I, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE. 2012;7:e34508 pubmed publisher
    ..We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. ..
  2. Scott R, Siegrist F, Foser S, Certa U. Interferon-alpha induces reversible DNA demethylation of the interferon-induced transmembrane protein-3 core promoter in human melanoma cells. J Interferon Cytokine Res. 2011;31:601-8 pubmed publisher
    The interferon (IFN)-? response gene interferon-induced transmembrane protein 3 (IFITM3) has antiproliferative properties in a number of biological systems...
  3. Jia R, Pan Q, Ding S, Rong L, Liu S, Geng Y, et al. The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization. J Virol. 2012;86:13697-707 pubmed publisher
    ..Significant enrichment of a minor IFITM3 allele was recently reported for patients who were hospitalized for seasonal and 2009 H1N1 pandemic flu...
  4. Li D, Peng Z, Tang H, Wei P, Kong X, Yan D, et al. KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res. 2011;17:3558-68 pubmed publisher
    b>IFITM3, an IFN-inducible gene, is overexpressed in human colorectal cancer...
  5. Mills T, Rautanen A, Elliott K, Parks T, Naranbhai V, Ieven M, et al. IFITM3 and susceptibility to respiratory viral infections in the community. J Infect Dis. 2014;209:1028-31 pubmed publisher
    ..We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with ..
  6. Everitt A, Clare S, Pertel T, John S, Wash R, Smith S, et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012;484:519-23 pubmed publisher
    ..Using a knockout mouse model, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo...
  7. Yount J, Karssemeijer R, Hang H. S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. J Biol Chem. 2012;287:19631-41 pubmed publisher
    The interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cellular restriction factor that inhibits infection by influenza virus and many other pathogenic viruses...
  8. Amini Bavil Olyaee S, Choi Y, Lee J, Shi M, Huang I, Farzan M, et al. The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. Cell Host Microbe. 2013;13:452-64 pubmed publisher
    ..We show that the antiviral effector protein interferon-inducible transmembrane protein 3 (IFITM3) interacts with VAPA and prevents its association with OSBP, thereby disrupting intracellular cholesterol ..
  9. Fan J, Peng Z, Zhou C, Qiu G, Tang H, Sun Y, et al. Gene-expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene-expression analyses: identification and validation of IFITM3 as a biomarker of early colon carcinogenesis. Cancer. 2008;113:266-75 pubmed publisher
    ..were differentially expressed in those 2 types of cells were identified, including a novel candidate tumor marker, IFITM3. Elevated IFITM3 expression in colon cancer cells was first confirmed using quantitative real-time polymerase ..
  10. Seo G, Lee J, Yu J, Yun K, Chae S, Choi S. Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. Exp Mol Med. 2010;42:99-104 pubmed publisher
    ..b>IFITM3 (also known as 1-8U) is a member of the IFITM family, and has been described as a key player in specification of ..
  11. Desai T, Marin M, Chin C, Savidis G, Brass A, Melikyan G. IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. PLoS Pathog. 2014;10:e1004048 pubmed publisher
    ..Here, we examined IAV restriction by IFITM3 protein using direct virus-cell fusion assay and single virus imaging in live cells...
  12. Lu J, Pan Q, Rong L, He W, Liu S, Liang C. The IFITM proteins inhibit HIV-1 infection. J Virol. 2011;85:2126-37 pubmed publisher
    ..candidates thus identified were interferon-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, that potently inhibit HIV-1 replication at least partially through interfering with virus entry...
  13. Jiang D, Weidner J, Qing M, Pan X, Guo H, Xu C, et al. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. J Virol. 2010;84:8332-41 pubmed publisher
    ..Mechanistic analyses revealed that two structurally related cell plasma membrane proteins, IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection...
  14. Chutiwitoonchai N, Hiyoshi M, Hiyoshi Yoshidomi Y, Hashimoto M, Tokunaga K, Suzu S. Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins. Microbes Infect. 2013;15:280-90 pubmed publisher
    ..These characteristics lead to a better understanding of the mechanism by which IFITMs restrict HIV-1 and other viruses...
  15. Anafu A, Bowen C, Chin C, Brass A, Holm G. Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry. J Biol Chem. 2013;288:17261-71 pubmed publisher
    ..One family member, IFITM3, localizes to late endosomes, where reoviruses undergo proteolytic disassembly; therefore, we sought to determine ..
  16. Perreira J, Chin C, Feeley E, Brass A. IFITMs restrict the replication of multiple pathogenic viruses. J Mol Biol. 2013;425:4937-55 pubmed publisher
    ..This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis. ..
  17. El Tanani M, Jin D, Campbell F, Johnston P. Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. Oncogene. 2010;29:752-62 pubmed publisher
    ..Using this approach we isolated interferon-induced transmembrane protein 3 gene (IFITM3) as a potential protein partner...
  18. Weidner J, Jiang D, Pan X, Chang J, Block T, Guo J. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol. 2010;84:12646-57 pubmed publisher
    Tetherin and IFITM3 are recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively...
  19. Li K, Markosyan R, Zheng Y, Golfetto O, Bungart B, Li M, et al. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013;9:e1003124 pubmed publisher
    ..syncytia formation and cell-cell fusion induced by almost all viral fusion proteins examined; IFITM2 and IFITM3 also strongly inhibited their fusion, with efficiency somewhat dependent on cell types...
  20. Suzuki Y, Nakazawa M, Suzuki K, Yamazaki H, Miyagawa Y. Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion. Jpn J Ophthalmol. 2011;55:256-263 pubmed publisher
    ..It is also suggested that the inflammatory reaction may be more activate in CRVO than in DR. ..
  21. Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, et al. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency. J Allergy Clin Immunol. 2015;135:425-40 pubmed publisher
    ..Our results suggest DNA-PK as a novel determinant of asthma and a potential target for the treatment of the disease. ..
  22. Baumgart D, Lowder J, Targan S, Sandborn W, Frankel M. Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease. Am J Gastroenterol. 2009;104:868-76 pubmed publisher
  23. Liu L, Wan X, Zhou P, Zhou X, Zhang W, Hui X, et al. The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis. J Hematol Oncol. 2018;11:27 pubmed publisher
    ..Our current studies uncover critical roles of Baf200 in both normal and malignant hematopoiesis and provide a potential therapeutic target for suppressing the progression of leukemia without interfering with normal hematopoiesis. ..
  24. Lei Q, Li L, Cai J, Huang W, Qin B, Zhang S. ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway. Viral Immunol. 2016;29:105-11 pubmed publisher
    ..The anti-inflammatory properties might be of great importance to clarify the role and mechanism of macrophages in chronic HEV infection and cirrhosis. ..
  25. Correani V, Di Francesco L, Mignogna G, Fabrizi C, Leone S, Giorgi A, et al. Plasma Membrane Protein Profiling in Beta-Amyloid-Treated Microglia Cell Line. Proteomics. 2017;17: pubmed publisher
    ..damaged tissues MAP/microtubule affinity-regulating kinase 3 (MARK3), Interferon-induced transmembrane protein 3 (IFITM3), Annexins A5 and A7 (ANXA5, ANXA7) and Neuropilin-1 (NRP1), all proteins known to be involved in the inflammation ..
  26. Wang J, Alexander J, Wiebe M, Jones C. Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity. Virus Res. 2014;185:72-6 pubmed publisher
    ..Collectively, these studies demonstrated that BoHV-1 infection stimulated inflammasome formation, which we predict is important for clinical symptoms in cattle. ..
  27. Shannon J, Murphy M, Kantheti U, Burnett J, Hahn M, Dorrity T, et al. Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA. Mol Immunol. 2018;99:182-190 pubmed publisher
    ..Our findings suggest that PQBP1 inhibits IFI16/cGAS-induced signaling in response to cytosolic DNA, in contrast to the role of this protein in response to retroviral infection. ..
  28. Ma L, Cao F, Tang R, Zhang J, Zhang S. Identification and characterization of a gamma-interferon-inducible lysosomal thiol reductase homolog from guinea pig (Cavia porcellus) that exhibits thiol reductase activity in vitro. Res Vet Sci. 2017;111:81-84 pubmed publisher
  29. Garcia Minambres A, Eid S, Mangan N, Pade C, Lim S, Matthews A, et al. Interferon epsilon promotes HIV restriction at multiple steps of viral replication. Immunol Cell Biol. 2017;95:478-483 pubmed publisher
    ..the infectivity of progeny virion particles likely by inducing expression of HIV restriction factors, such as IFITM3, which act at that stage of infection...
  30. Johnston A, PIRO A, Clough B, Siew M, Virreira Winter S, Coers J, et al. Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. Cell Microbiol. 2016;18:1056-64 pubmed publisher
    ..This study highlights fundamental differences between human and murine GBPs and underlines the need to study the functions of GBPs at cellular locations away from PVs. ..
  31. Peng W, Luo P, Gui D, Jiang W, Wu H, Zhang J. Enhanced anticancer effect of fabricated gallic acid/CdS on the rGO nanosheets on human glomerular mesangial (IP15) and epithelial proximal (HK2) kidney cell lines - Cytotoxicity investigations. J Photochem Photobiol B. 2018;178:243-248 pubmed publisher
    ..show that excellent properties of as-prepared GA/CdS-rGO has ability to treat the human glomerular mesangial (IP15) cancer cells at 50μg/ml as an IC50 value, without affecting the epithelial proximal (HK-2) normal ..
  32. Yu L, Xu Y, Wang F, Yang C, Liu G, Song X. Functional Roles of Pattern Recognition Receptors That Recognize Virus Nucleic Acids in Human Adipose-Derived Mesenchymal Stem Cells. Biomed Res Int. 2016;2016:9872138 pubmed publisher
    ..All these results indicated that PRRs recognizing virus nucleic acids were expressed and can mediate antivirus responses in hAD-MSCs. ..
  33. Huang J, Lyu J, Liu Z. [Advances in the research of the relationship between interferon-inducible protein-10 and liver injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:185-188 pubmed publisher
    ..In this paper, IP-10 in different types of liver injury in the pathogenesis of research progress were reviewed to provide valuable indicators for clinical diagnosis, treatment strategy and prognosis evaluation of liver injury. ..
  34. Cocho L, Fernández I, Calonge M, Martínez V, González García M, Caballero D, et al. Biomarkers in Ocular Chronic Graft Versus Host Disease: Tear Cytokine- and Chemokine-Based Predictive Model. Invest Ophthalmol Vis Sci. 2016;57:746-58 pubmed publisher
    ..These results add further knowledge to the search for potential biomarkers in this devastating ocular inflammatory disease. ..
  35. Yu J, Li M, Wilkins J, Ding S, Swartz T, Esposito A, et al. IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein. Cell Rep. 2015;13:145-156 pubmed publisher
    ..Here, we provide evidence that IFITM proteins, particularly IFITM2 and IFITM3, specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection...
  36. Abella G, Pena R, Nogareda C, Armengol R, Vidal A, Moradell L, et al. A WUR SNP is associated with European Porcine Reproductive and Respiratory Virus Syndrome resistance and growth performance in pigs. Res Vet Sci. 2016;104:117-22 pubmed publisher
    ..Based on these results, there is a scope for selecting pigs according to their responses to PRRS virus infection with European strains and that WUR SNP may play a role in causing PRRSV resistance. ..
  37. Sasai M, Sakaguchi N, Ma J, Nakamura S, Kawabata T, Bando H, et al. Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense. Nat Immunol. 2017;18:899-910 pubmed publisher
    ..Thus, GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. ..
  38. Bassano I, Ong S, Lawless N, Whitehead T, Fife M, Kellam P. Accurate characterization of the IFITM locus using MiSeq and PacBio sequencing shows genetic variation in Galliformes. BMC Genomics. 2017;18:419 pubmed publisher
    ..Locus resequencing using these capture probes and RNA-seq based expression analysis will allow the further characterization of genetic diversity within Galliformes. ..
  39. Fan F, Xu Z, Zhou Q, Wang D. [Expression profiles and clinical implication of plasma chemokines in patients with Stanford type A aortic dissection]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:318-322 pubmed publisher
    ..05)?IP?10(r(2)?0.00?P>0.05)?Flt?3??(r(2)?0.02?P>0.05)?????C???????????? ??? ??MIP?1??ENA?78?????IL?16???????Stanford A???????????????????C?????????????IP?10?Flt?3?????Stanford A???????????????. ..
  40. Crow M, Cristea I. Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation. Mol Cell Proteomics. 2017;16:S200-S214 pubmed publisher
    ..Altogether, our study demonstrates that IFIX antiviral functions work in part via viral transcriptional suppression and that HSV-1 has acquired mechanisms to block its functions via proteasome-dependent degradation. ..
  41. Diner B, Lum K, Toettcher J, Cristea I. Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection. MBio. 2016;7: pubmed publisher
    ..Our live-cell imaging, mass spectrometry-based proteomics, CRISPR-based cellular assays, and optogenetics underscore the value of integrative approaches to uncover complex cellular responses against pathogens. ..
  42. Lin W, Zhao Z, Ni Z, Zhao Y, Du W, Chen S. IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome. Cell Prolif. 2017;50: pubmed publisher
    ..In this study, we investigated the anti-tumour role of IFI16 in hepatocellular carcinoma (HCC)...
  43. Cheng Y, Liu Y, Wang Y, Niu Q, Gao Q, Fu Q, et al. Chicken DNA virus sensor DDX41 activates IFN-β signaling pathway dependent on STING. Dev Comp Immunol. 2017;76:334-342 pubmed publisher
    ..Therefore, our results suggest that chDDX41 is involved in the dsDNA- and dsDNA virus-mediated chDDX41-chSTING-IFN-β signaling pathway in chicken cells. ..
  44. McMahan Z, Cottrell T, Wigley F, Antiochos B, Zambidis E, Park T, et al. Enrichment of Scleroderma Vascular Disease-Associated Autoantigens in Endothelial Lineage Cells. Arthritis Rheumatol. 2016;68:2540-9 pubmed publisher
    ..High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens. ..
  45. Hwang J, Kwon M, Jung S, Park M, Kim D, Cho W, et al. RNA-Seq transcriptome analysis of the olive flounder (Paralichthys olivaceus) kidney response to vaccination with heat-inactivated viral hemorrhagic septicemia virus. Fish Shellfish Immunol. 2017;62:221-226 pubmed publisher
  46. Cui K, Wang H, Zai S, Feng Y. [Expression of IFITM3 in colorectal carcinoma and its clinical significance]. Zhonghua Zhong Liu Za Zhi. 2015;37:352-5 pubmed
    To investigate the expression of IFITM3 in colorectal carcinoma and its clinical significance...
  47. Nezos A, Gravani F, Tassidou A, Kapsogeorgou E, Voulgarelis M, Koutsilieris M, et al. Type I and II interferon signatures in Sjogren's syndrome pathogenesis: Contributions in distinct clinical phenotypes and Sjogren's related lymphomagenesis. J Autoimmun. 2015;63:47-58 pubmed publisher
    ..Additionally, IFNγ/IFNα mRNA ratio in diagnostic salivary gland biopsies is proposed as a novel histopathological biomarker for the prediction of in situ lymphoma development in the setting of SS. ..
  48. Koyama N, Hakura A, Toritsuka N, Sonoda J, Seki Y, Tohyama O, et al. Wif1 and Ifitm3 gene expression preferentially altered in the colon mucosa of benzo[a]pyrene pre-treated mice following exposure to dextran sulfate sodium. Chem Biol Interact. 2015;240:164-70 pubmed publisher
    ..6-fold increase) and interferon induced membrane protein 3 (Ifitm3; 5.7-fold increase)...
  49. Foster T, Wilson H, Iyer S, Coss K, Doores K, Smith S, et al. Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction. Cell Host Microbe. 2016;20:429-442 pubmed publisher
    ..However, viral sensitivity to IFITMs, particularly IFITM2 and IFITM3, increases over the first 6 months of infection, primarily as a result of neutralizing antibody escape mutations...
  50. Barjesteh N, Shojadoost B, Brisbin J, Emam M, Hodgins D, Nagy Ã, et al. Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens. Vaccine. 2015;33:4843-9 pubmed publisher
    ..Moreover, the expression of several candidate genes, such as type I interferons, PKR, OAS, viperin and IFITM3 was quantified at 3, 8 and 18h post-treatment with TLR ligands...
  51. Stacey M, Clare S, Clement M, Marsden M, Abdul Karim J, Kane L, et al. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. J Clin Invest. 2017;127:1463-1474 pubmed publisher
    The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans...
  52. Bi K, Han K, Liu Q, Zhao D, Huang X, Liu Y, et al. Molecular cloning, characterization, and expression of duck 2'-5'-oligoadenylate synthetase-like gene. Gene. 2017;629:43-51 pubmed publisher
    ..These results provide a solid foundation for performing further studies to determine the mechanism underlying the antiviral effect of duOASL at the cellular level. ..
  53. Saeij J, Frickel E. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Curr Opin Microbiol. 2017;40:72-80 pubmed publisher
    ..Elucidation of murine Toxoplasma defense mechanisms are guiding studies on human cells, while inevitably leading to the discovery of human-specific pathways that often function in a cell type-dependent manner. ..
  54. Zhang L, Adyshev D, Singleton P, Li H, Cepeda J, Huang S, et al. Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. FEBS Lett. 2008;582:1802-8 pubmed publisher
    ..between PBEF and NADH dehydrogenase subunit 1(ND1), ferritin light chain and interferon induced transmembrane 3 (IFITM3) in human pulmonary vascular endothelial cells were identified and validated...
  55. Wang Y, Pan Q, Ding S, Wang Z, Yu J, Finzi A, et al. The V3 Loop of HIV-1 Env Determines Viral Susceptibility to IFITM3 Impairment of Viral Infectivity. J Virol. 2017;91: pubmed publisher
    ..that the infectivity of different HIV-1 primary isolates, including transmitted founder viruses, is diminished by IFITM3 to various levels, with strain AD8-1 exhibiting strong resistance...
  56. Narayana S, Helbig K, McCartney E, Eyre N, Bull R, Eltahla A, et al. The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. J Biol Chem. 2015;290:25946-59 pubmed publisher
    ..as a potent antiviral effector against hepatitis C virus (HCV), whereas the related family members IFITM2 and IFITM3 have been described to have antiviral effects against a broad range of RNA viruses...
  57. Liu D, Hong F, Zhou J, Zhang Y. Lung inflammation caused by long-term exposure to titanium dioxide in mice involving in NF-κB signaling pathway. J Biomed Mater Res A. 2017;105:720-727 pubmed publisher
    ..Therefore, more attention should be placed on the application of TiO2 NPs and their potential long-term effects, especially in human beings. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 720-727, 2017. ..
  58. Shaaban Hanafy A. Impact of hepatitis B vaccination on HBsAg kinetics, interferon-inducible protein 10 level and recurrence of viremia. Cytokine. 2017;99:99-105 pubmed publisher
    ..The vaccine had no significant effect on HOMA-IR nor fibroscan value. HBV vaccine was efficient in enhancing IP-10 level with HBsAg clearance, or reduction to a favorable level. ClinicalTrials.gov Identifier: NCT03193775. ..
  59. Ndika J, Airaksinen L, Suojalehto H, Karisola P, Fyhrquist N, Puustinen A, et al. Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis. J Allergy Clin Immunol. 2017;140:1288-1298 pubmed publisher
    ..Moreover, when compared with patients with SAR, healthy subjects exhibit an antagonistic proteomic response across seasons, which might prove to be a therapeutic target for disease prevention. ..
  60. Man S, Place D, Kuriakose T, Kanneganti T. Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation. J Leukoc Biol. 2017;101:143-150 pubmed publisher
    ..Here, we provide an overview on the emerging relationship between GBPs and activation of the inflammasome in innate immunity to microbial pathogens. ..
  61. Poddar S, Hyde J, Gorman M, Farzan M, Diamond M. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. J Virol. 2016;90:8780-94 pubmed publisher
    ..b>IFITM3 is a small transmembrane ISG that restricts a broad range of viruses, including orthomyxoviruses, flaviviruses, ..
  62. Zhou Q, Hu J, Hu H. Analysis of changes in joint function and peripheral blood mononuclear cells in patients with systemic lupus erythematosus and intervention effects of different drugs. Eur Rev Med Pharmacol Sci. 2017;21:4423-4430 pubmed
  63. Xu H, Sun L, Zheng Y, Yu S, Ou Yang J, Han H, et al. GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis. Biochem Biophys Res Commun. 2018;495:446-453 pubmed publisher
    ..Taken together, these results for the first time suggest that GBP3 contributes to the proliferation of glioma cells via regulating SQSTM1-ERK1/2 pathway, and GBP3 might represent as a new potential therapeutic target against glioma. ..
  64. Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, et al. Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Nature. 2017;551:378-383 pubmed publisher
    ..flexneri lacking ipaH9.8. The mode of IpaH9.8 action highlights the functional importance of GBPs in antibacterial defences. IpaH9.8 and S. flexneri provide a unique system for dissecting GBP-mediated immunity. ..
  65. Desai T, Marin M, Mason C, Melikyan G. pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion. J Biol Chem. 2017;292:7817-7827 pubmed publisher
    ..Collectively, these results highlight the role of cell-extrinsic and cell-intrinsic factors in regulating the efficiency and kinetics of virus entry and fusion with target cells. ..
  66. Yang X, Tan B, Zhou X, Xue J, Zhang X, Wang P, et al. Interferon-Inducible Transmembrane Protein 3 Genetic Variant rs12252 and Influenza Susceptibility and Severity: A Meta-Analysis. PLoS ONE. 2015;10:e0124985 pubmed publisher
    ..Previous studies suggested a close association between the interferon-induced transmembrane protein-3 (IFITM3) genetic variant rs12252 and influenza...
  67. Zhao X, Sehgal M, Hou Z, Cheng J, Shu S, Wu S, et al. Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses. J Virol. 2018;92: pubmed publisher
    ..However, we demonstrated previously that human IFITM2 and IFITM3 are essential host factors facilitating the entry of human coronavirus (HCoV) OC43...
  68. Dzananovic E, Astha -, Chojnowski G, Deo S, Booy E, Padilla Meier P, et al. Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition. PLoS ONE. 2017;12:e0186849 pubmed publisher
    ..Therefore, we propose that instead of simply sequestering PKR, a specific structural conformation of the PKR-VAI complex may be required for inhibition...
  69. Gorman M, Poddar S, Farzan M, Diamond M. The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. J Virol. 2016;90:8212-25 pubmed publisher
    ..As few studies have evaluated the importance of Ifitm3 in vivo in restricting viral pathogenesis, we investigated its significance as an antiviral gene against West Nile ..
  70. Li P, Shi M, Shen W, Zhang Z, Xie D, Zhang X, et al. Coordinated regulation of IFITM1, 2 and 3 genes by an IFN-responsive enhancer through long-range chromatin interactions. Biochim Biophys Acta Gene Regul Mech. 2017;1860:885-893 pubmed publisher
    ..assay and in vivo CRISPR-Cas9 genome editing, we identified an IFN-responsive enhancer located 35kb upstream of IFITM3 gene promoter upregulating the IFN-induced expression of IFITM1, 2 and 3 genes...
  71. Gaio V, Nunes B, Pechirra P, Conde P, Guiomar R, Dias C, et al. Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection: A Case-Control Study. PLoS ONE. 2016;11:e0158181 pubmed publisher
    Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection...
  72. Makvandi Nejad S, Laurenson Schafer H, Wang L, Wellington D, Zhao Y, Jin B, et al. Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection. J Infect Dis. 2017;: pubmed publisher
    Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection...
  73. Vaarala M, Porvari K, Kyllönen A, Vihko P. Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression. Lab Invest. 2000;80:1259-68 pubmed
  74. Pan Y, Yang P, Dong T, Zhang Y, Shi W, Peng X, et al. IFITM3 Rs12252-C Variant Increases Potential Risk for Severe Influenza Virus Infection in Chinese Population. Front Cell Infect Microbiol. 2017;7:294 pubmed publisher
    b>Background: Interferon Inducible Transmembrane 3 (IFITM3) is a key factor in interferon pathway and it involves host's immune response against multiple viruses...
  75. You H, Yuan H, Fu W, Su C, Wang W, Cheng T, et al. Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein. Antiviral Res. 2017;143:69-73 pubmed publisher
    ..For the first time, HSV-1 UL41 was demonstrated to evade the antiviral function of Ch25h via its endonuclease activity. ..
  76. Shimizu Y, Yasuda S, Kimura T, Nishio S, Kono M, Ohmura K, et al. Interferon-inducible Mx1 protein is highly expressed in renal tissues from treatment-naïve lupus nephritis, but not in those under immunosuppressive treatment. Mod Rheumatol. 2018;28:661-669 pubmed publisher
    ..These results suggest that Mx1 is a potential marker for the diagnosis of SLE in the peripheral blood and also for the activity of lupus nephritis in the kidney. ..
  77. Tartour K, Appourchaux R, Gaillard J, Nguyen X, Durand S, Turpin J, et al. IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity. Retrovirology. 2014;11:103 pubmed publisher
    ..These results raise the possibility that IFITMs could similarly affect distinct steps of the life cycle of a number of other viruses. ..
  78. Stankovic N, Hoppmann N, Teodorczyk M, Kim E, Bros M, Giese A, et al. No role of IFITM3 in brain tumor formation in vivo. Oncotarget. 2016;7:86388-86405 pubmed publisher
    ..patient-derived BTPCs revealed a significant upregulation of the interferon-inducible transmembrane protein 3 (IFITM3), suggesting the protein as a factor mediating radio resistance...
  79. Ngo C, Man S. Mechanisms and functions of guanylate-binding proteins and related interferon-inducible GTPases: Roles in intracellular lysis of pathogens. Cell Microbiol. 2017;19: pubmed publisher
    ..We also highlight unresolved questions related to the regulation of GBPs in cell-autonomous immunity to intracellular pathogens...
  80. Lee N, Cao B, Ke C, Lu H, Hu Y, Tam C, et al. IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza. J Infect Dis. 2017;216:97-104 pubmed publisher
    We examined associations between single-nucleotide polymorphisms (SNPs) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese...
  81. Feng B, Zhao L, Wang W, Wang J, Wang H, Duan H, et al. Investigation of antiviral state mediated by interferon-inducible transmembrane protein 1 induced by H9N2 virus and inactivated viral particle in human endothelial cells. Virol J. 2017;14:213 pubmed publisher
    ..Our results showed that inactivated viral particle inoculation increased the expression of IFITM1 at mRNA and protein levels. Moreover, the induction of IFITM1 expression mediated the antiviral state in HUVECs. ..
  82. David S, Correia V, Antunes L, Faria R, Ferrão J, Faustino P, et al. Population genetics of IFITM3 in Portugal and Central Africa reveals a potential modifier of influenza severity. Immunogenetics. 2018;70:169-177 pubmed publisher
    Influenza epidemics are a serious global public health and economic problem. The IFITM3 allele (rs12252-C) was suggested as a population-based genetic risk factor for severe influenza virus infection by A(H1N1)pdm09...
  83. Savidis G, Perreira J, Portmann J, Meraner P, Guo Z, Green S, et al. The IFITMs Inhibit Zika Virus Replication. Cell Rep. 2016;15:2323-30 pubmed publisher
    ..Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle...
  84. Ling S, Zhang C, Wang W, Cai X, Yu L, Wu F, et al. Combined approaches of EPR and NMR illustrate only one transmembrane helix in the human IFITM3. Sci Rep. 2016;6:24029 pubmed publisher
    Interferon-inducible transmembrane protein IFITM3 was known to restrict the entry of a wide spectrum of viruses to the cytosol of the host...
  85. Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, et al. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem. 2013;288:35093-103 pubmed publisher
    ..Interferon-induced transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1) to reduce its antiviral activity, mediated by ..