IFITM1

Summary

Gene Symbol: IFITM1
Description: interferon induced transmembrane protein 1
Alias: 9-27, CD225, DSPA2a, IFI17, LEU13, interferon-induced transmembrane protein 1, dispanin subfamily A member 2a, interferon-induced protein 17, interferon-inducible protein 9-27, leu-13 antigen
Species: human
Products:     IFITM1

Top Publications

  1. Yang Y, Lee J, Kim K, Song H, Kim J, Yoon S, et al. The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells. Cancer Lett. 2005;221:191-200 pubmed
    ..Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells. ..
  2. Pan Z, Chen S, Pan X, Wang Z, Han H, Zheng W, et al. Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization. Neoplasma. 2010;57:123-8 pubmed
    ..Our results revealed that ACADVL, CEBPB, IFITM1 and DNAJC9 are involved in cervical carcinogenesis.
  3. Lu J, Pan Q, Rong L, He W, Liu S, Liang C. The IFITM proteins inhibit HIV-1 infection. J Virol. 2011;85:2126-37 pubmed publisher
    ..Among the ISG candidates thus identified were interferon-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, that potently inhibit HIV-1 replication at least partially through interfering with virus ..
  4. Perreira J, Chin C, Feeley E, Brass A. IFITMs restrict the replication of multiple pathogenic viruses. J Mol Biol. 2013;425:4937-55 pubmed publisher
    ..This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis. ..
  5. Ding S, Pan Q, Liu S, Liang C. HIV-1 mutates to evade IFITM1 restriction. Virology. 2014;454-455:11-24 pubmed publisher
    ..In this study, we have utilized HIV-1 as a model and selected IFITM1-resistant viruses after multiple passages of HIV-1 in IFITM1-expressing SupT1 cells...
  6. Kelly J, Gilbert C, Stark G, Kerr I. Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons. Eur J Biochem. 1985;153:367-71 pubmed
    ..There must, therefore, be differences in how the levels of different mRNAs are sustained by alpha-interferons and how alpha- and gamma-interferons regulate the levels of the same mRNAs. ..
  7. Friedman R, Manly S, McMahon M, Kerr I, Stark G. Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell. 1984;38:745-55 pubmed
    ..This rate begins to fall after 4-6 hr, reaching the uninduced level by 8-12 hr. Since the mRNA continues to accumulate after 8-12 hr, posttranscriptional events must also play a role in increasing its level. ..
  8. Hatano H, Kudo Y, Ogawa I, Tsunematsu T, Kikuchi A, Abiko Y, et al. IFN-induced transmembrane protein 1 promotes invasion at early stage of head and neck cancer progression. Clin Cancer Res. 2008;14:6097-105 pubmed publisher
    ..We identified IFN-induced transmembrane protein 1 (IFITM1) as a candidate gene for promoting the invasion of HNSCC by comparing the gene expression profiles between parent ..
  9. Gomes A, Correia D, Grosso A, Lança T, Ferreira C, Lacerda J, et al. Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells. Haematologica. 2010;95:1397-404 pubmed publisher
    ..Within this panel, 3 genes (ULBP1, TFR2 and IFITM1) were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity, whereas the other 7 (CLEC2D, ..

More Information

Publications110 found, 100 shown here

  1. Lee J, Goh S, Song N, Hwang J, Nam S, Choi I, et al. Overexpression of IFITM1 has clinicopathologic effects on gastric cancer and is regulated by an epigenetic mechanism. Am J Pathol. 2012;181:43-52 pubmed publisher
    ..gene expression profiling and found overexpressed levels of human interferon-induced transmembrane protein 1 (IFITM1). We validated the gastric cancer-specific up-regulation of IFITM1 and its association with cancer progression...
  2. Li K, Markosyan R, Zheng Y, Golfetto O, Bungart B, Li M, et al. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013;9:e1003124 pubmed publisher
    ..b>IFITM1 profoundly suppressed syncytia formation and cell-cell fusion induced by almost all viral fusion proteins examined;..
  3. Mudhasani R, Tran J, Retterer C, Radoshitzky S, Kota K, Altamura L, et al. IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus. J Virol. 2013;87:8451-64 pubmed publisher
    ..Collectively, our data provide new insights into the possible mechanisms by which the IFITM family members restrict distinct viruses. ..
  4. Deblandre G, Marinx O, Evans S, Majjaj S, Leo O, Caput D, et al. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J Biol Chem. 1995;270:23860-6 pubmed
  5. Xu Y, Yang G, Hu G. Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation. Acta Biochim Biophys Sin (Shanghai). 2009;41:488-94 pubmed
    Interferon-induced transmembrane protein 1 (IFITM1) is an essential mediator of interferon-g-induced antiproliferation...
  6. Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
    ..We discovered that the interferon-inducible transmembrane proteins IFITM1, 2, and 3 restrict an early step in influenza A viral replication...
  7. Yu F, Ng S, Chow B, Sze J, Lu G, Poon W, et al. Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. J Neurooncol. 2011;103:187-95 pubmed publisher
    Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known...
  8. Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
    Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein...
  9. Chan Y, Huang I, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE. 2012;7:e34508 pubmed publisher
    ..We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. ..
  10. Warren C, Griffin L, Little A, Huang I, Farzan M, Pyeon D. The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus. PLoS ONE. 2014;9:e96579 pubmed publisher
    ..of keratinocytes substantially decreases human papillomavirus 16 (HPV16) infection while robustly inducing IFITM1, 2 and 3 expression...
  11. Weston S, Czieso S, White I, Smith S, Kellam P, Marsh M. A membrane topology model for human interferon inducible transmembrane protein 1. PLoS ONE. 2014;9:e104341 pubmed publisher
    InterFeron Inducible TransMembrane proteins 1-3 (IFITM1, IFITM2 and IFITM3) are a family of proteins capable of inhibiting the cellular entry of numerous human and animal viruses...
  12. Smith S, Busse D, Binter Š, Weston S, Diaz Soria C, Laksono B, et al. Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane. J Virol. 2019;93: pubmed publisher
    ..In contrast, IFITM1 has not been studied in detail...
  13. Li C, Zheng H, Wang Y, Dong W, Liu Y, Zhang L, et al. Antiviral Role of IFITM Proteins in Classical Swine Fever Virus Infection. Viruses. 2019;11: pubmed publisher
    The proteins IFITM1, IFITM2, and IFITM3 are host effectors against a broad range of RNA viruses whose roles in classical swine fever virus (CSFV) infection had not yet been reported...
  14. Gómez Herranz M, Nekulova M, Faktor J, Hernychova L, Kote S, Sinclair E, et al. The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis. Cell Signal. 2019;60:39-56 pubmed publisher
    Interferon-induced transmembrane proteins IFITM1 and IFITM3 (IFITM1/3) play a role in both RNA viral restriction and in human cancer progression...
  15. Zhu X, He Z, Hu Y, Wen W, Lin C, Yu J, et al. MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. PLoS Negl Trop Dis. 2014;8:e3088 pubmed publisher
    ..of miR-30e* upregulated IFN-β and the downstream IFN-stimulated genes (ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication...
  16. Inaba J, Thornton J, Huergo L, Monteiro R, Klassen G, Pedrosa F, et al. Mutational analysis of GlnB residues critical for NifA activation in Azospirillum brasilense. Microbiol Res. 2015;171:65-72 pubmed publisher
    ..Biochemical and computational analyses suggest that residue Leu13, located in the α helix 1 of GlnB, is important to maintain GlnB trimeric structure and function...
  17. Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P. Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. J Gen Virol. 2015;96:170-82 pubmed publisher
    ..We showed that RSV infection enhanced the expression of a series of ISGs, including oligoadenylate synthetase 2, IFITM1 (IFN-induced transmembrane protein 1) and myxovirus resistance 2...
  18. Escher T, Lui A, Geanes E, Walter K, Tawfik O, Hagan C, et al. Interaction between MUC1 and STAT1 drives IFITM1 overexpression in aromatase inhibitor-resistant breast cancer cells and mediates estrogen-induced apoptosis. Mol Cancer Res. 2019;: pubmed publisher
    ..stimulates transcription of interferon-stimulated genes, specifically interferon-induced transmembrane protein 1 (IFITM1)...
  19. Schmaltz Panneau B, Cordova A, Dhorne Pollet S, Hennequet Antier C, Uzbekova S, Martinot E, et al. Early bovine embryos regulate oviduct epithelial cell gene expression during in vitro co-culture. Anim Reprod Sci. 2014;149:103-16 pubmed publisher
    ..Of these 34 genes, IFI6, ISG15, MX1, IFI27, IFI44, RSAD2, IFITM1, EPSTI1, USP18, IFIT5, and STAT1 expression increased to the greatest extent due to the presence of embryos with a ..
  20. Popson S, Ziegler M, Chen X, Holderfield M, Shaaban C, Fong A, et al. Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterioscler Thromb Vasc Biol. 2014;34:1011-9 pubmed publisher
    ..Here, we aimed to define the role of human interferon-induced transmembrane protein 1 (IFITM1) during blood vessel formation...
  21. van der Lans A, Boon M, Haks M, Quinten E, Schaart G, Ottenhoff T, et al. Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects. Physiol Rep. 2015;3: pubmed publisher
    ..01), IFITM1/3 (+11%, P < 0.05), CD274 (+36%, P < 0.05) and STAT 2 (+10%, P < 0.05)...
  22. Jacobs E, Keating S, Abdel Mohsen M, Gibb S, Heitman J, Inglis H, et al. Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression. J Virol. 2017;91: pubmed publisher
    ..The combination of the EC-associated cytokines induced expression of the anti-HIV host restriction factors IFITM1 and IFITM2 and suppressed expression of RNase L and SAMHD1...
  23. Hussein H, Briestenská K, Mistrikova J, Akula S. IFITM1 expression is crucial to gammaherpesvirus infection, in vivo. Sci Rep. 2018;8:14105 pubmed publisher
    ..KSHV infection of B- and endothelial cells to significantly upregulate the expression of interferon induced transmembrane protein 1 (IFITM1) which in turn enhances virus entry. This is an extension of the above study...
  24. Ma Y, Zhang G, Fu X, Xia O, Zhan C, Li L, et al. Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression. Oncol Rep. 2010;23:1569-76 pubmed
    ..key regulator of the activated Wnt/beta-catenin signaling pathway, appears to stimulate interferon-induced gene 1 (IFITM1) products in intestinal tumorigenesis. Both contribute to intestinal tumor formation and tumor progression...
  25. Yu J, Liu S. The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage. Viruses. 2018;10: pubmed publisher
    ..that in U87 glioblastoma cells IFITM proteins inhibit HIV-1 entry in a co-receptor-dependent manner, that is, IFITM1 is more inhibitory on CCR5 tropic HIV-1 whereas IFITM2/3 confers a greater suppression of CXCR4 counterparts...
  26. Yu M, Qi W, Huang Z, Zhang K, Ye J, Liu R, et al. Expression profile and histological distribution of IFITM1 and IFITM3 during H9N2 avian influenza virus infection in BALB/c mice. Med Microbiol Immunol. 2015;204:505-14 pubmed publisher
    ..Here, we investigated the expression patterns and tissue distribution of IFITM1 and IFITM3 in BALB/c mice by infection with H9N2 AIV strains with only a PB2 residue 627 difference...
  27. Smith J, Sadeyen J, Butter C, Kaiser P, Burt D. Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease. J Virol. 2015;89:2469-82 pubmed publisher
    ..Antiviral genes, including IFNA, IFNG, MX1, IFITM1, IFITM3, and IFITM5, were upregulated in response to infection...
  28. Xue W, Wang H, Wang Z, Qiu M, Che J, Deng F, et al. Cloning and characterization of ifitm1 and ifitm3 expression during early zebrafish development. Zygote. 2016;24:149-58 pubmed publisher
    ..In the present study, the full-length cDNAs of zebrafish ifitm1 (744 bp) and ifitm3 (702 bp) were obtained by rapid amplification of cDNA ends (RACE)...
  29. Kidani S, Okuzaki Y, Kaneoka H, Asai S, Murakami S, Murase Y, et al. Expression of interferon-inducible transmembrane proteins in the chicken and possible role in prevention of viral infections. Cytotechnology. 2017;69:477-484 pubmed publisher
    ..The results obtained revealed that IFITM3 was expressed at a higher level than IFITM1, 2 and 5, in both embryonic and adult organs...
  30. Muñoz Moreno R, Cuesta Geijo M, Martínez Romero C, Barrado Gil L, Galindo I, Garcia Sastre A, et al. Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection. PLoS ONE. 2016;11:e0154366 pubmed publisher
    ..Expression of IFITM1, 2 and 3 reduced virus infectivity in Vero cells, with IFITM2 and IFITM3 having an impact on viral entry/uncoating...
  31. He L, Vanlandewijck M, Raschperger E, Andaloussi Mäe M, Jung B, Lebouvier T, et al. Analysis of the brain mural cell transcriptome. Sci Rep. 2016;6:35108 pubmed publisher
    ..expression of two novel markers, vitronectin (Vtn) and interferon-induced transmembrane protein 1 (Ifitm1), using fluorescent in situ hybridization and immunohistochemistry...
  32. Wentink M, van Zelm M, van Dongen J, Warnatz K, van der Burg M. Deficiencies in the CD19 complex. Clin Immunol. 2018;195:82-87 pubmed publisher
    Signaling via the CD19-complex, consisting of CD19, CD81, CD21 and CD225, is critically important for B-cell development, differentiation and maturation. In this complex, each protein has its own distinct function...
  33. Ali R, Al Safi R, Al Waheeb S, John B, Al Ali W, Al Jassar W, et al. Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait. Hum Pathol. 2014;45:2453-62 pubmed publisher
    ..Organization classification system and to assess the diagnostic use of interferon-induced transmembrane protein 1 (IFITM1) immunomarker for ESSs...
  34. Grow E, Flynn R, CHAVEZ S, Bayless N, Wossidlo M, Wesche D, et al. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells. Nature. 2015;522:221-5 pubmed publisher
    ..of one such product, the HERVK accessory protein Rec, in a pluripotent cell line is sufficient to increase IFITM1 levels on the cell surface and inhibit viral infection, suggesting at least one mechanism through which HERVK can ..
  35. Janssen A, Betzel B, Stoopen G, Berends F, Janssen I, Peijnenburg A, et al. The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. BMC Genomics. 2015;16:760 pubmed publisher
    ..g. CXCL9-11, CCL8, CX3CL1, CXCL6), interferon γ-induced genes (e.g. IFITM1, IFIT1, IFIT2, IFIT3) and numerous other immune-related genes (e.g. TLR3, NOS2, and LCN2)...
  36. Wahadat M, Bodewes I, Maria N, van Helden Meeuwsen C, van Dijk Hummelman A, Steenwijk E, et al. Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?. Arthritis Res Ther. 2018;20:4 pubmed publisher
    ..real-time quantitative PCR (RT-PCR) expression values of IFN-I signature genes (IFI44, IFI44L, IFIT1, Ly6e, MxA, IFITM1) in CD14+ monocytes of cSLE patients and healthy controls (HCs)...
  37. Lanz C, Yángüez E, Andenmatten D, Stertz S. Swine interferon-inducible transmembrane proteins potently inhibit influenza A virus replication. J Virol. 2015;89:863-9 pubmed publisher
    ..Given the important role of pigs in the zoonotic cycle of IAV, we cloned swine IFITMs (swIFITMs) and found two IFITM1-like proteins, one homologue of IFITM2, and a homologue of IFITM3...
  38. Raposo R, de Mulder Rougvie M, Paquin Proulx D, Brailey P, Cabido V, Zdinak P, et al. IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis. JCI Insight. 2017;2:e85811 pubmed publisher
    ..we generated latently infected CD4+ T cells and identified interferon-induced transmembrane protein 1 (IFITM1), a transmembrane antiviral factor, as being overexpressed in latently infected cells...
  39. Li K, Jia R, Li M, Zheng Y, Miao C, Yao Y, et al. A sorting signal suppresses IFITM1 restriction of viral entry. J Biol Chem. 2015;290:4248-59 pubmed publisher
    ..Here, we show that differences in the range of viruses restricted by IFITM1 are regulated by a C-terminal non-canonical dibasic sorting signal KRXX that suppresses restriction of some ..
  40. Choi H, Lui A, Ogony J, Jan R, Sims P, Lewis Wambi J. Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death. Breast Cancer Res. 2015;17:6 pubmed publisher
    ..In the present study, we assessed the functional role of IFITM1 and PLSCR1; two well-known interferon response genes in AI resistance...
  41. Rabbani M, Ribaudo M, Guo J, Barik S. Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. J Virol. 2016;90:11145-11156 pubmed
    ..screening a set of ISG proteins we discovered that several other such proteins also inhibited PIV3, including IFITM1, IDO (indoleamine 2,3-dioxygenase), PKR (protein kinase, RNA activated), and viperin (virus inhibitory protein, ..
  42. Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed
    ..hrHPV effectively inhibited IFN?/TNF?-mediated arrest of cell growth at the S-phase by downregulating IFITM1 already at 48?h after hrHPV infection, followed by an impaired increase in the expression of the ..
  43. Wang B, Lam T, Soh M, Ye Z, Chen J, Ren E. Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins. Front Immunol. 2018;9:1193 pubmed publisher
    ..of a large set of interferon-inducible genes, among which the interferon-induced transmembrane family members IFITM1, IFITM2, and IFITM3 were most significantly downregulated by the expression of p53...
  44. Hussein H, Akula S. miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1). Sci Rep. 2017;7:17972 pubmed publisher
    ..show the ability of host cell novel miR-36 to specifically inhibit KSHV-induced expression of interferon induced transmembrane protein 1 (IFITM1) to limit virus infection of cells...
  45. Blyth G, Chan W, Webster R, Magor K. Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses. J Virol. 2016;90:103-16 pubmed publisher
    ..We identify and sequence duck IFITM1, IFITM2, IFITM3, and IFITM5...
  46. Lebosse F, Testoni B, Fresquet J, Facchetti F, Galmozzi E, Fournier M, et al. Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B. J Hepatol. 2017;66:897-909 pubmed publisher
    ..A subset of genes [CXCL10, GBP1, IFITM1, IFNB1, IL10, IL6, ISG15, TLR3, SOCS1, SOCS3] was more repressed in HBeAg(-) respect to HBeAg(+) patients (median ..
  47. Zheng W, Zhao Z, Yi X, Zuo Q, Li H, Guo X, et al. Down-regulation of IFITM1 and its growth inhibitory role in cervical squamous cell carcinoma. Cancer Cell Int. 2017;17:88 pubmed publisher
    Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues...
  48. Fu Y, Zhou Z, Wang H, Gong P, Guo R, Wang J, et al. IFITM1 suppresses expression of human endogenous retroviruses in human embryonic stem cells. FEBS Open Bio. 2017;7:1102-1110 pubmed publisher
    Interferon-induced transmembrane protein 1 (IFITM1), a member of the IFITM protein family, is a component of a multimeric complex involved in the transduction of antiproliferation and cell adhesion signals...
  49. Takahashi S, Doss C, Levy S, Levy R. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol. 1990;145:2207-13 pubmed
    ..These results suggest that TAPA-1 and Leu-13 form a complex on the cell surface and play a role in growth control through a common pathway. ..
  50. Gao F, Liang H, Lu H, Wang J, Xia M, Yuan Z, et al. Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach. Clin Epigenetics. 2015;7:86 pubmed publisher
    ..HCC pairs on the Illumina MiSeq platform confirmed that 7 genes showed either promoter hyper-methylation (SMAD6, IFITM1, LRRC4, CHST4, and TBX15) or hypo-methylation (CCL20 and NQO1) in HCC...
  51. Wentink M, Lambeck A, van Zelm M, Simons E, van Dongen J, Ijspeert H, et al. CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities. Clin Immunol. 2015;161:120-7 pubmed publisher
    Deficiencies in CD19 and CD81 (forming the CD19-complex with CD21 and CD225) cause a severe clinical phenotype. One CD21 deficient patient has been described...
  52. Weston S, Czieso S, White I, Smith S, Wash R, Diaz Soria C, et al. Alphavirus Restriction by IFITM Proteins. Traffic. 2016;17:997-1013 pubmed publisher
    ..The late endosomal IFITM2 is less restrictive and the plasma membrane IFITM1 does not inhibit normal infection by either virus...
  53. Hung K, Harris P, Desai A, Marshall J, Brimble M. Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality. Eur J Med Chem. 2017;136:154-164 pubmed publisher
    ..In this study fourteen A20FMDV2 analogues incorporating non-proteinogenic substitutes of the native Lys16 and Leu13 residues and six A20FMDV2 analogues containing modified N- and C-termini were synthesised to increase the half-..
  54. Smith J, Smith N, Yu L, Paton I, Gutowska M, Forrest H, et al. A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance. BMC Genomics. 2015;16:574 pubmed publisher
    ..In ducks, IFITM1, 2 and 3 are strongly up regulated in response to highly pathogenic avian influenza, where little response is seen ..
  55. Ranjbar S, Haridas V, Jasenosky L, Falvo J, Goldfeld A. A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection. Cell Rep. 2015;13:874-83 pubmed publisher
    ..Simultaneous knockdown of IFITM1, IFITM2, and IFITM3 by RNAi significantly enhances MTb growth in human monocytic and alveolar/epithelial cells, ..
  56. Hornick A, Li N, Oakland M, McCray P, Sinn P. Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors. Hum Gene Ther. 2016;27:354-62 pubmed publisher
    ..GP64- and VSV-G (vesicular stomatitis virus G glycoprotein)-pseudotyped FIV, we show that expression of mouse IFITM1, IFITM2, and IFITM3 restricts gene transfer...
  57. Thyagarajan N, Marshall J, Pickett A, Schumacher C, Yang Y, Christian S, et al. Transcriptomic Analysis of THP-1 Macrophages Exposed to Lipoprotein Hydrolysis Products Generated by Lipoprotein Lipase. Lipids. 2017;52:189-205 pubmed publisher
    ..associated with the cell cycle (PCNA and DKC1 variant 3), stress response (ATF3), type I interferon signaling (IFITM1), and lipid metabolism (CD36 and PLIN2) were significantly affected by LPL hydrolysis products...
  58. Bassano I, Ong S, Lawless N, Whitehead T, Fife M, Kellam P. Accurate characterization of the IFITM locus using MiSeq and PacBio sequencing shows genetic variation in Galliformes. BMC Genomics. 2017;18:419 pubmed publisher
    ..substitution of A63V in the CIL domain of IFITM2 compared to Red Jungle fowl and 13, 13 and 11 differences between IFITM1, 2 and 3 of chickens and turkeys, respectively...
  59. De Vincentis G, Scopinaro F, Varvarigou A, Ussof W, Schillaci O, Archimandritis S, et al. Phase I trial of technetium [Leu13] bombesin as cancer seeking agent: possible scintigraphic guide for surgery?. Tumori. 2002;88:S28-30 pubmed
    ..ABNs in turn are able to bind to mammalian and human receptors in vitro, and it is therefore interesting to study radioisotope-labeled bombesin (BN) and BN-like peptides as cancer seeking agents...
  60. Yu F, Xie D, Ng S, Lum C, Cai M, Cheung W, et al. IFITM1 promotes the metastasis of human colorectal cancer via CAV-1. Cancer Lett. 2015;368:135-143 pubmed publisher
    Interferon-induced transmembrane protein 1 (IFITM1) is one of the interferon-induced transmembrane protein family members...
  61. Gjøen J, Jenum S, Sivakumaran D, Mukherjee A, Macaden R, Kabra S, et al. Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children. Sci Rep. 2017;7:5839 pubmed publisher
    ..36 asymptomatic household controls, and identified a 7- and a 10-transcript signature, both including NOD2, GBP5, IFITM1/3, KIF1B and TNIP1...
  62. Chesarino N, Compton A, McMichael T, Kenney A, Zhang L, Soewarna V, et al. IFITM3 requires an amphipathic helix for antiviral activity. EMBO Rep. 2017;18:1740-1751 pubmed publisher
    ..The homologous amphipathic helix within IFITM1 is also required for the inhibition of infection, indicating that IFITM proteins possess a conserved mechanism of ..
  63. Sanfilippo C, Cambria D, Longo A, Palumbo M, Avola R, Pinzone M, et al. SERPING1 mRNA overexpression in monocytes from HIV+ patients. Inflamm Res. 2017;66:1107-1116 pubmed publisher
    ..Noteworthy, the expression levels of IFITM1-an antiviral molecule belonging to the genes network-correlate positively with SERPING1 expression...
  64. Li D, Yang Z, Liu Z, Zou Q, Yuan Y. DDR2 and IFITM1 Are Prognostic Markers in Gallbladder Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas. Pathol Oncol Res. 2019;25:157-167 pubmed publisher
    This study was conducted to investigate the expressions of DDR2 and IFITM1 and their clinical and pathological significances in the rare type squamous cell/adenosquamous carcinomas (SC/ASC) and ordinary adenocarcinomas (AC) of gallbladder ..
  65. Kita K, Sugaya S, Zhai L, Wu Y, Wano C, Chigira S, et al. Involvement of LEU13 in interferon-induced refractoriness of human RSa cells to cell killing by X rays. Radiat Res. 2003;160:302-8 pubmed
    ..X irradiation when they were treated with IFNA prior to irradiation, showed increased expression levels of LEU13 (IFITM1) mRNA after IFNA treatment alone...
  66. Akyerli C, Beksac M, Holko M, Frevel M, Dalva K, Ozbek U, et al. Expression of IFITM1 in chronic myeloid leukemia patients. Leuk Res. 2005;29:283-6 pubmed
    We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS)...
  67. Ma Y, Wu B, Xia O. [Expression and significance of interferon-inducible transmembrane protein-1 gene in Peutz-Jeghers syndrome]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:541-3 pubmed
    To detect the mRNA and protein expression of interferon-inducible transmembrane protein-1 (IFITM1) in Peutz-Jeghers syndrome (PJS) and investigate the role of IFITM1 in the occurrence, development and carcinogenesis of PJS polyps...
  68. Wilkins C, Woodward J, Lau D, Barnes A, Joyce M, McFarlane N, et al. IFITM1 is a tight junction protein that inhibits hepatitis C virus entry. Hepatology. 2013;57:461-9 pubmed publisher
    ..Interferon-induced transmembrane protein 1 (IFITM1) is an ISG product that suppresses early stage infection by a number of viruses through an unknown mechanism of ..
  69. Siegel B, Sengupta E, Edelson J, Lewis D, Volk D. Elevated viral restriction factor levels in cortical blood vessels in schizophrenia. Biol Psychiatry. 2014;76:160-7 pubmed publisher
  70. Compton A, Bruel T, Porrot F, Mallet A, Sachse M, Euvrard M, et al. IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell Host Microbe. 2014;16:736-47 pubmed publisher
    ..Thus, IFITM proteins act additively in both productively infected cells and uninfected target cells to inhibit HIV-1 spread, potentially conferring these proteins with greater breadth and potency against enveloped viruses. ..
  71. Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, et al. Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment. J Virol. 2015;89:3049-61 pubmed publisher
    ..Therefore, our findings may provide a new platform for dissecting the molecular mechanism of action of IFITMs during the blocking or enhancement of virus infection, which are under intense investigation in this field. ..
  72. Kusano K, Gainer H, Battey J, Fathi Z, Wada E. Receptor-activated currents in mouse fibroblasts expressing transfected bombesin receptor subtype cDNAs. Am J Physiol. 1993;265:C869-76 pubmed
    ..N-acetyl-GRP-(20-26) amide, [Leu13-psi(CH2NH)-Leu14]Bn, and [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P also blocked GRP Rt responses but at higher ..
  73. Fumoto S, Shimokuni T, Tanimoto K, Hiyama K, Otani K, Ohtaki M, et al. Selection of a novel drug-response predictor in esophageal cancer: a novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response. Int J Oncol. 2008;32:413-23 pubmed
    ..b>Interferon induced transmembrane protein 1 (IFITM1) gene alone, being suggested as a key gene of Wnt pathway, was commonly selected in both ..
  74. Kim B, Kim H, Kim J, You Y, Zadeh H, Shin H, et al. IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells. Bone. 2012;51:506-14 pubmed publisher
    ..a highly expressed protein that had a high degree of homology with interferon-induced transmembrane protein 1 (IFITM1) was identified using differentially expressed gene (DEG) screening...
  75. Bhanja Chowdhury J, Shrivastava S, Steele R, Di Bisceglie A, Ray R, Ray R. Hepatitis C virus infection modulates expression of interferon stimulatory gene IFITM1 by upregulating miR-130A. J Virol. 2012;86:10221-5 pubmed publisher
    We have examined the underlying mechanism of hepatitis C virus (HCV)-mediated IFITM1 regulation. IFITM1 is a potential target of miR-130a...
  76. Chutiwitoonchai N, Hiyoshi M, Hiyoshi Yoshidomi Y, Hashimoto M, Tokunaga K, Suzu S. Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins. Microbes Infect. 2013;15:280-90 pubmed publisher
    IFN-inducible IFITM proteins (IFITM1, 2, and 3) inhibit the replication of various viruses including HIV-1 through poorly understood mechanisms. Here, we further analyzed characteristics of these newly identified HIV-1 restriction factors...
  77. Shah V, Aiken C. Gene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent manner. PLoS ONE. 2014;9:e92724 pubmed publisher
    ..Our study provides gene expression data that may be useful for future efforts to identify the putative CypA-dependent HIV-1 restriction factor and in studies of other cell-specific phenotypes. ..
  78. Kim N, Sung H, Choi E, Lyu D, Choi H, Ju W, et al. Aberrant DNA methylation in the IFITM1 promoter enhances the metastatic phenotype in an intraperitoneal xenograft model of human ovarian cancer. Oncol Rep. 2014;31:2139-46 pubmed publisher
    ..regulate the expression of one of the profoundly upregulated genes, interferon-induced transmembrane protein 1 (IFITM1), in the metastatic implants...
  79. Busca A, Djordjevic B, Giassi A, Parra Herran C. IFITM1 Is Superior to CD10 as a Marker of Endometrial Stroma in the Evaluation of Myometrial Invasion by Endometrioid Adenocarcinoma. Am J Clin Pathol. 2016;145:486-96 pubmed publisher
    ..aimed to compare CD10, which has limited value in this scenario, with interferon-induced transmembrane protein 1 (IFITM1), a recently described sensitive and specific marker of endometrial stroma...
  80. Gorman M, Poddar S, Farzan M, Diamond M. The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. J Virol. 2016;90:8212-25 pubmed publisher
    ..Moreover, transcomplementation experiments showed that Ifitm3 inhibited WNV infection independently of Ifitm1, Ifitm2, Ifitm5, and Ifitm6...
  81. Reid L, Brasnett A, Gilbert C, Porter A, Gewert D, Stark G, et al. A single DNA response element can confer inducibility by both alpha- and gamma-interferons. Proc Natl Acad Sci U S A. 1989;86:840-4 pubmed
    ..Since the 6-16 gene does not normally respond to IFN-gamma, the context of the ISRE must determine the specificity of the response. ..
  82. Raychoudhuri A, Shrivastava S, Steele R, Kim H, Ray R, Ray R. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J Virol. 2011;85:12881-9 pubmed publisher
    ..indicated that virus infection suppresses the upregulation of a subset of effector molecules, including ISG56 and IFITM1. Similar results were observed for HCV-infected Huh7 cells...
  83. Ma Z, Guo W, Niu H, Yang F, Wang R, Jiang Y, et al. Transcriptome network analysis reveals potential candidate genes for esophageal squamous cell carcinoma. Asian Pac J Cancer Prev. 2012;13:767-73 pubmed
    ..arose as a hub node in our transcriptome network, along with some transcription factors like CCNB1, TAP1, RARG and IFITM1 proven to be related with ESCC by previous studies...
  84. Tartour K, Appourchaux R, Gaillard J, Nguyen X, Durand S, Turpin J, et al. IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity. Retrovirology. 2014;11:103 pubmed publisher
    ..These results raise the possibility that IFITMs could similarly affect distinct steps of the life cycle of a number of other viruses. ..
  85. Qian J, Le Duff Y, Wang Y, Pan Q, Ding S, Zheng Y, et al. Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins. Virology. 2015;474:10-8 pubmed publisher
    ..These results suggest that IFITM proteins exploit similar mechanisms to inhibit the entry of both pH-independent primate lentiviruses and the pH-dependent influenza A viruses. ..
  86. Narayana S, Helbig K, McCartney E, Eyre N, Bull R, Eltahla A, et al. The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. J Biol Chem. 2015;290:25946-59 pubmed publisher
    ..b>IFITM1 has been identified as a potent antiviral effector against hepatitis C virus (HCV), whereas the related family ..
  87. Yu J, Li M, Wilkins J, Ding S, Swartz T, Esposito A, et al. IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein. Cell Rep. 2015;13:145-156 pubmed publisher
    ..Overall, our study uncovers a mechanism by which IFITM proteins specifically antagonize HIV-1 Env to restrict HIV-1 infection and provides insight into the specialized role of IFITMs in HIV infection. ..
  88. He J, Li J, Feng W, Chen L, Yang K. Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer. Int J Clin Exp Pathol. 2015;8:16007-13 pubmed
    Interferon-induced transmembrane protein 1 (IFITM1) has recently been implicated in tumorigenesis. However, the prognostic value of IFITM1 in colorectal cancer remains unknown...
  89. Ogony J, Choi H, Lui A, Cristofanilli M, Lewis Wambi J. Interferon-induced transmembrane protein 1 (IFITM1) overexpression enhances the aggressive phenotype of SUM149 inflammatory breast cancer cells in a signal transducer and activator of transcription 2 (STAT2)-dependent manner. Breast Cancer Res. 2016;18:25 pubmed publisher
    ..In the present study, we investigated the role of interferon-induced transmembrane protein 1 (IFITM1), a well-known interferon-stimulated gene (ISG), in promoting the aggressiveness of SUM149 IBC cells...
  90. Sari I, Yang Y, Phi L, Kim H, Baek M, Jeong D, et al. Interferon-induced transmembrane protein 1 (IFITM1) is required for the progression of colorectal cancer. Oncotarget. 2016;7:86039-86050 pubmed publisher
    Interferon-induced transmembrane protein 1 (IFITM1) has been shown to be implicated in multiple cancers, yet little is known about biological significance of IFITM1 in colorectal cancer...
  91. Li P, Shi M, Shen W, Zhang Z, Xie D, Zhang X, et al. Coordinated regulation of IFITM1, 2 and 3 genes by an IFN-responsive enhancer through long-range chromatin interactions. Biochim Biophys Acta Gene Regul Mech. 2017;1860:885-893 pubmed publisher
    ..IFN-responsive enhancer located 35kb upstream of IFITM3 gene promoter upregulating the IFN-induced expression of IFITM1, 2 and 3 genes...
  92. Bradbury L, Kansas G, Levy S, Evans R, Tedder T. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol. 1992;149:2841-50 pubmed
    ..Together, these data suggest that TAPA-1 and Leu-13 are broadly expressed members of a signal transduction complex in which lineage-specific proteins, such as CD19 and CD21, provide cell-specific functions. ..