Gene Symbol: IFIT3
Description: interferon induced protein with tetratricopeptide repeats 3
Alias: CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon-induced protein with tetratricopeptide repeats 3, CIG49, IFI-60K, IFIT-3, IFIT-4, ISG-60, interferon-induced 60 kDa protein, interferon-induced protein with tetratricopeptide repeats 4, retinoic acid-induced gene G protein
Species: human
Products:     IFIT3

Top Publications

  1. Diamond M, Farzan M. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Nat Rev Immunol. 2013;13:46-57 pubmed publisher
    ..This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses...
  2. Yu M, Tong J, Mao M, Kan L, Liu M, Sun Y, et al. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes. Proc Natl Acad Sci U S A. 1997;94:7406-11 pubmed
    ..A synergistic induction of RIG-G expression in NB4 cells by combined treatment with ATRA and IFNs suggests that a collaboration exists between their respective signaling pathways. ..
  3. Xiao S, Li D, Zhu H, Song M, Pan X, Jia P, et al. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc Natl Acad Sci U S A. 2006;103:16448-53 pubmed
  4. Huang X, Yang N, Ou X, Li D, Wang Z, Xie Q, et al. Sequential activation of protein kinase C delta and JNK is required for interferon-alpha-induced expression of IFIT4. Cell Signal. 2008;20:112-9 pubmed
    ..In this study, we investigated the mechanisms of expression regulation of IFIT4 (interferon induced protein with tetratricopeptide repeats 4) by IFN-alpha...
  5. Liu X, Chen W, Wei B, Shan Y, Wang C. IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J Immunol. 2011;187:2559-68 pubmed publisher
    ..In this study, we report that IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) is significantly induced upon RNA virus infection...
  6. de Veer M, Sim H, Whisstock J, Devenish R, Ralph S. IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes. Genomics. 1998;54:267-77 pubmed
    ..a new member of the human IFI54 (HGMW-approved symbol IFIT2) gene family, designated IFI60 (HGMW-approved symbol IFIT4)...
  7. Lou Y, Pan X, Jia P, Li D, Xiao S, Zhang Z, et al. IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1. Cancer Res. 2009;69:3673-80 pubmed publisher
  8. Stawowczyk M, Van Scoy S, Kumar K, Reich N. The interferon stimulated gene 54 promotes apoptosis. J Biol Chem. 2011;286:7257-66 pubmed publisher
    ..Analyses of binding partners of ISG54 revealed association with two homologous proteins, ISG56/IFIT1 and ISG60/IFIT3. In addition, ISG60 binding negatively regulates the apoptotic effects of ISG54...
  9. Schmeisser H, Mejido J, Balinsky C, Morrow A, Clark C, Zhao T, et al. Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. J Virol. 2010;84:10671-80 pubmed publisher
    ..Of the 25 genes, 10 have not been previously linked to AV activity of IFN-?. The most upregulated gene was IFIT3 (for IFN-induced protein with tetratricopeptide repeats 3)...

More Information


  1. Bansode Y, Chattopadhyay D, Saha B. Innate immune response in astrocytes infected with herpes simplex virus 1. Arch Virol. 2019;164:1433-1439 pubmed publisher
    ..receptors 2, 6 and 9, MDA5, and DAI along with an increase in the expression of type I interferons and interferon-stimulated genes such as IFIT1, IFIT3 and RNase L. These genes encode proteins that mediate the antiviral immune response.
  2. Wichit S, Hamel R, Zanzoni A, Diop F, Cribier A, Talignani L, et al. SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts. Int J Mol Sci. 2019;20: pubmed publisher
    ..We show that the expression of the interferon-stimulated proteins MX1, IFIT1, IFIT3 and ISG15, as well as expression of defense response proteins DDX58, STAT1, OAS3, EIF2AK2 and SAMHD1 was ..
  3. Shi P, Su Y, Li R, Liang Z, Dong S, Huang J. PEDV nsp16 negatively regulates innate immunity to promote viral proliferation. Virus Res. 2019;265:57-66 pubmed publisher
    ..In turn, the mRNA levels of IFIT family members (IFIT1, IFIT2, IFIT3) was inhibited in cells overexpressing nsp16. In addition, nsp10 enhanced the inhibitory effect of nsp16 on IFN-β...
  4. Pidugu V, Wu M, Yen A, Pidugu H, Chang K, Liu C, et al. IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling. Oncogene. 2019;38:3232-3247 pubmed publisher
    IFIT1 and IFIT3 are abundant products of interferon-stimulating genes. While the importance of IFIT1 and IFIT3 in the prognosis of cancer has been reported, the molecular basis of IFIT1 and IFIT3 in cancer progression remains unexplored...
  5. Ovstebø R, Olstad O, Brusletto B, Møller A, Aase A, Haug K, et al. Identification of genes particularly sensitive to lipopolysaccharide (LPS) in human monocytes induced by wild-type versus LPS-deficient Neisseria meningitidis strains. Infect Immun. 2008;76:2685-95 pubmed publisher
    ..pathway, and an unknown number of IFN-beta-inducible genes, such as those for CXCL9, CXCL10, CXCL11, IFIT1, IFIT2, IFIT3, and IFIT5, are transcribed...
  6. Imaizumi T, Sassa N, Kawaguchi S, Matsumiya T, Yoshida H, Seya K, et al. Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells. J Neuroimmunol. 2018;324:16-21 pubmed publisher
    ..agonist polyinosinic-polycytidylic acid (poly IC) induces the expression of interferon (IFN)-stimulated gene 60 (ISG60), and this reaction was mediated by IFN-?...
  7. Nushtaeva A, Stepanov G, Semenov D, Juravlev E, Balahonova E, Gerasimov A, et al. Characterization of primary normal and malignant breast cancer cell and their response to chemotherapy and immunostimulatory agents. BMC Cancer. 2018;18:728 pubmed publisher
    ..2 and 3 and aromatase CYP19, as well as expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) mRNA in human breast cells were characterized...
  8. Sanpui P, Zheng X, Loeb J, Bisesi J, Khan I, Afrooz A, et al. Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells. Part Fibre Toxicol. 2014;11:66 pubmed publisher
    ..protein levels of targets involved in inflammation and anti-viral activity (INFβ1, IL-8, RANTES/CCL5, IFIT2, IFIT3, ST3GAL4, ST6GAL1, IL-10), localized sialic acid receptors, and assessed mitochondrial function...
  9. Guan G, Shen Y, Yu Q, Liu H, Zhang B, Guo Y, et al. Down-regulation of IFIT3 protects liver from ischemia-reperfusion injury. Int Immunopharmacol. 2018;60:170-178 pubmed publisher
    ..As one of the Interferon (IFN)-stimulated genes, IFIT3 exerted antitumor activity but its roles in hepatic IRI are still unknown...
  10. Bodewes I, Huijser E, van Helden Meeuwsen C, Tas L, Huizinga R, Dalm V, et al. TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis. J Autoimmun. 2018;91:97-102 pubmed publisher
    ..pSS, SLE, SSc and TLR7-stimulated HCs downregulated the expression of the ISGs MxA, IFI44, IFI44L, IFIT1 and IFIT3. TBK1 inhibition reduced expression of ISGs in PBMCs from IFNpos patients with systemic autoimmune diseases ..
  11. Ternette N, Wright C, Kramer H, Altun M, Kessler B. Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection. Virol J. 2011;8:442 pubmed
    ..Synthesis of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) mRNAs were found to be highly induced upon RSV infection in a time dependent ..
  12. Zou Q, Xu G, Zhuang L, Zhang Z, Yan W, Zhang Y, et al. [Mechanisms regulating p21 gene expression by retinoic acid-induced gene G protein]. Zhonghua Zhong Liu Za Zhi. 2014;36:657-61 pubmed
    ..RIG-G protein may suppress the phosphorylation of c-Jun protein through different signal pathways, thereby increasing the expression of p21 gene, arresting the cell cycle and inhibiting the cell growth in U937 cells. ..
  13. Guo C, Chen L, Mo D, Chen Y, Liu X. DRACO inhibits porcine reproductive and respiratory syndrome virus replication in vitro. Arch Virol. 2015;160:1239-47 pubmed publisher
    ..when viral replication was enhanced by knockdown of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in Marc-145 cells...
  14. Makjaroen J, Somparn P, Hodge K, Poomipak W, Hirankarn N, Pisitkun T. Comprehensive Proteomics Identification of IFN-λ3-regulated Antiviral Proteins in HBV-transfected Cells. Mol Cell Proteomics. 2018;17:2197-2215 pubmed publisher
    ..Our proteomic data suggests that IFN-λ3 regulates an array of cellular processes to control HBV replication. ..
  15. Chen H, Zheng X, Nicholas J, Humes S, Loeb J, Robinson S, et al. Single-walled carbon nanotubes modulate pulmonary immune responses and increase pandemic influenza a virus titers in mice. Virol J. 2017;14:242 pubmed publisher
    ..The expression of tlr3, ifn?1, rantes, ifit2, ifit3, and il8 was induced by IAV alone but several anti-viral targets showed a repressed trend (ifits) with pre-..
  16. Gao J, Fan M, Xiang G, Wang J, Zhang X, Guo W, et al. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Cell Death Dis. 2017;8:e2765 pubmed publisher
    ..HL-60 cells with Dip G was associated with a remarkable upregulation of STAT1 target gene expression, including IFIT3 and CXCL10...
  17. Sanfilippo C, Pinzone M, Cambria D, Longo A, Palumbo M, Di Marco R, et al. OAS Gene Family Expression Is Associated with HIV-Related Neurocognitive Disorders. Mol Neurobiol. 2018;55:1905-1914 pubmed publisher
    ..OAS gene network analysis showed that several genes belonging to the type I IFN pathway, especially CXCL10 and IFIT3, were similarly upregulated in SIVE/HAND...
  18. Janssen A, Betzel B, Stoopen G, Berends F, Janssen I, Peijnenburg A, et al. The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. BMC Genomics. 2015;16:760 pubmed publisher
    ..g. CXCL9-11, CCL8, CX3CL1, CXCL6), interferon γ-induced genes (e.g. IFITM1, IFIT1, IFIT2, IFIT3) and numerous other immune-related genes (e.g. TLR3, NOS2, and LCN2)...
  19. Zhou H, Brekman A, Zuo W, Ou X, Shaykhiev R, Agosto Perez F, et al. POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. J Immunol. 2016;196:3159-67 pubmed publisher
    ..upregulation of POU2AF1 in airway basal cells induced upregulation of host defense genes, including MX1, IFIT3, IFITM, and known POU2AF1 downstream genes HLA-DRA, ID2, ID3, IL6, and BCL6...
  20. Jiang S, Zhang Q, Su Y, Pan L. Network-Based Differential Analysis to Identify Molecular Features of Tumorigenesis for Esophageal Squamous Carcinoma. Molecules. 2018;23: pubmed publisher
    ..In addition, six genes (RBPMS2, PDK4, IGK, SBSN, IFIT3 and HSPB6) were likely to be the biomarkers of tumorigenesis for esophageal squamous carcinoma due to ..
  21. Hare N, Chan B, Chan E, Kaufman K, Britton W, Saunders B. Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. Proteomics. 2015;15:3020-9 pubmed publisher
    ..Prominent among these were the type I interferon inducible proteins, ISG15, IFIT1, IFIT2, and IFIT3. Exposure of uninfected THP-1 cells to TBinf-MPs induced increased gene expression of isg15, ifit1, ifit2, and ..
  22. McDonald J, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, et al. A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease. mSystems. 2016;1: pubmed
    ..frequently expressed following RSV infection with no assigned function in RSV control, including IFI27, IFIT3, IFI44L, GBP1, OAS3, IFI44, and IRF7...
  23. Armas González E, Díaz Martín A, Domínguez Luis M, Arce Franco M, Herrera García A, Hernández Hernández M, et al. Differential Antigen-presenting B Cell Phenotypes from Synovial Microenvironment of Patients with Rheumatoid and Psoriatic Arthritis. J Rheumatol. 2015;42:1825-34 pubmed publisher
    ..Expression of interferon-induced protein with tetratricopeptide repeats 4 (IFIT4) in immune-selected CD20+ cells from patients with RA was assessed by quantitative realtime PCR...
  24. Skovbjerg S, Nordén R, Martner A, Samuelsson E, Hynsjö L, Wold A. Intact Pneumococci Trigger Transcription of Interferon-Related Genes in Human Monocytes, while Fragmented, Autolyzed Bacteria Subvert This Response. Infect Immun. 2017;85: pubmed publisher
    ..These included IFNB1 and a large set of interferon-induced genes, such as IFIT3, RSAD2, CFCL1, and CXCL10 genes, as well as IL12B and CD40 genes...
  25. Zahoor M, Xue G, Sato H, Aida Y. Genome-wide transcriptional profiling reveals that HIV-1 Vpr differentially regulates interferon-stimulated genes in human monocyte-derived dendritic cells. Virus Res. 2015;208:156-63 pubmed publisher
    ..in innate immune responses (interferon-stimulated genes [ISGs]), including MX1, MX2, ISG15, ISG20, IFIT1, IFIT2, IFIT3, IFI27, IFI44L, and TNFSF10, were validated by real-time quantitative PCR; the results were consistent with the ..
  26. Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
    ..Long-term high fat diet significantly altered 55 proteins associated with immune response (e.g. IGTB2, IFIT3, LGALS1) and rennin angiotensin system (e.g. ENPEP, CMA1, CPA3, ANPEP)...
  27. Rabbani M, Ribaudo M, Guo J, Barik S. Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. J Virol. 2016;90:11145-11156 pubmed
    ..We found that IFIT1 significantly inhibited PIV3, whereas IFIT2, IFIT3, and IFIT5 were less effective or not at all...
  28. White C, Kessler P, Dickerman B, Ozato K, Sen G. Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members. J Biol Chem. 2016;291:13535-45 pubmed publisher
    ..Here, we investigated the mechanism for the observed differential induction of the mouse Ifit1, Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory ..
  29. Oguejiofor C, Cheng Z, Abudureyimu A, Anstaett O, Brownlie J, Fouladi Nashta A, et al. Global transcriptomic profiling of bovine endometrial immune response in vitro. II. Effect of bovine viral diarrhea virus on the endometrial response to lipopolysaccharide. Biol Reprod. 2015;93:101 pubmed publisher
    ..Top down-regulated genes were RSAD2, ISG15, BST2, MX2, OAS1, USP18, IFIT3, IFI27, SAMD9, IFIT1, and DDX58, whereas TRIM56, C3, and OLFML1 were most up-regulated...
  30. Petzke M, Iyer R, Love A, Spieler Z, Brooks A, Schwartz I. Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice. BMC Microbiol. 2016;16:29 pubmed publisher
    ..burgdorferi. The mean values for transcripts of Ifnb, Cxcl10, Gbp1, Ifit1, Ifit3, Irf7, Mx1, and Stat2 were found to be significantly increased in B...
  31. Choi Y, Bowman J, Jung J. A Talented Duo: IFIT1 and IFIT3 Patrol Viral RNA Caps. Immunity. 2018;48:474-476 pubmed publisher
    ..Johnson et al. (2018) solved the structure of the IFIT1-IFIT3 complex bound cap 0 RNA and explored their concerted antiviral activity.
  32. Johnson B, Vanblargan L, Xu W, White J, Shan C, Shi P, et al. Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity. 2018;48:487-499.e5 pubmed publisher
    ..structure of cap 0 (m7GpppN) RNA bound to human IFIT1 in complex with the C-terminal domain of human IFIT3. Structural, biochemical, and genetic studies suggest that IFIT3 binding to IFIT1 has dual regulatory functions: ..
  33. Kazezian Z, Li Z, Alini M, Grad S, Pandit A. Injectable hyaluronic acid down-regulates interferon signaling molecules, IGFBP3 and IFIT3 in the bovine intervertebral disc. Acta Biomater. 2017;52:118-129 pubmed publisher
    ..that expression of the anti-proliferative interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and pro-apoptotic insulin-like growth factor-binding protein-3 (IGFBP3), are up-regulated as downstream targets ..
  34. Yang Y, Yang W, Huo W, Huo P, Yang H. Identification of biomarkers for ischemic cardiomyopathy based on microarray data analysis. Cardiol J. 2017;24:305-313 pubmed publisher
    ..The PPI network revealed certain hub nodes such as CXCL10, IRF1, STAT1, IFIT2, and IFIT3. Candidate biomarker genes such as CXCL10, IRF1, STAT1, IFIT2, and IFIT3 may be suitable therapeutic targets for ..
  35. Cheng Z, Chauhan L, Barry A, Abudureyimu A, Oguejiofor C, Chen X, et al. Acute bovine viral diarrhea virus infection inhibits expression of interferon tau-stimulated genes in bovine endometrium. Biol Reprod. 2017;96:1142-1153 pubmed publisher
    ..virus markedly inhibited IFNT-stimulated expression of 15 ISGs tested (ISG15, HERC5, USP18, DDX58, IFIH1, IFIT1, IFIT3, BST2, MX1, MX2, RSAD2, OAS1Y, SAMD9, GBP4, and PLAC8), together with ISG15 secreted protein...
  36. Zhu H, Cong J, Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci U S A. 1997;94:13985-90 pubmed
    ..These RNAs accumulate after infection with virus that has been inactivated by treatment with UV light, indicating that the inducer is present in virions. We conclude that human cytomegalovirus induces interferon-responsive mRNAs. ..
  37. Niess H, Camaj P, Mair R, Renner A, Zhao Y, Jäckel C, et al. Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular "pseudoinflammation" contributing to an aggressive phenotype. Oncotarget. 2015;6:3306-18 pubmed
    ..Gene array data recently identified upregulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in aggressive pancreatic cancer cells...
  38. Lou Y, Pan X, Jia P, Zhang Z, Xu G, Li D, et al. [Role of the interferon-stimulated response elements I/II in expression regulation of the retinoic acid induced gene G]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:255-8 pubmed publisher
    ..Both ISRE I and ISRE II on the RIG-G promoter are the binding sites for the complex of transcription factors. They are required for RIG-G expression, and ISRE I has a preferential role over ISRE II. ..
  39. Lou Y, Zhang Z, Pan X, Xu G, Jia P, Li D, et al. Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene. Exp Cell Res. 2011;317:513-20 pubmed publisher
    ..This work will be of great benefit to us for a better understanding of the mechanisms on RIG-G gene expression regulation. ..
  40. Doehle B, Chang K, Fleming L, McNevin J, Hladik F, McElrath M, et al. Vpu-deficient HIV strains stimulate innate immune signaling responses in target cells. J Virol. 2012;86:8499-506 pubmed publisher
    ..These observations show that HIV-1 can indeed be recognized as a pathogen in infected cells and provide a novel and effective platform for defining the native innate immune programs of target cells of HIV-1 infection. ..
  41. Hsu Y, Shi S, Wu W, Ho L, Lai J. Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells. PLoS ONE. 2013;8:e79518 pubmed publisher
    ..we investigated the effects and mechanisms of action of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in human lung epithelial cells...
  42. Ohnishi J, Ayuzawa S, Nakamura S, Sakamoto S, Hori M, Sasaoka T, et al. Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study. Hum Genomics. 2017;11:21 pubmed publisher
    ..e., MX1, RSAD2, IFIT1, IFIT3, IFI27, IFI44L, and HERC5), and the genes C17orf97 (ligand of arginyltranseferase 1; ATE1), hemoglobin ?A (HBG1), ..
  43. Torres Odio S, Key J, Hoepken H, Canet Pons J, Valek L, Roller B, et al. Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. J Neuroinflammation. 2017;14:154 pubmed publisher
    ..Marked dysregulations of microbial defense factors Ifit3 and Rsad2 were consistently observed upon five analyses: (1) Pink1 -/- primary neurons in the first ..
  44. Zhao Y, Altendorf Hofmann A, Pozios I, Camaj P, Däberitz T, Wang X, et al. Elevated interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a poor prognostic marker in pancreatic ductal adenocarcinoma. J Cancer Res Clin Oncol. 2017;143:1061-1068 pubmed publisher
    Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) gene from IFITs family is one gene among hundreds of IFN-stimulated genes. The potential role of IFIT3 in cancer is scarcely understood...
  45. Hou Z, Zhang J, Han Q, Su C, Qu J, Xu D, et al. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. Sci Rep. 2016;6:26150 pubmed publisher
  46. Lou Y, Pan X, Jia P, Jin J, Tong J. RIG-G inhibits the proliferation of NB4 cells and propels ATRA-induced differentiation of APL cells. Leuk Res. 2016;40:83-9 pubmed publisher
    ..These results indicated that RIG-G level was high in maturated cells and low in blast cells, and suggested that RIG-G might play a role in the differentiation of bone marrow hemocytes in vivo. ..
  47. Jackson V, Ntalla I, Sayers I, Morris R, Whincup P, Casas J, et al. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax. 2016;71:501-9 pubmed publisher
    ..08×10(-6), preplication=0.019) and a rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288, pmeta=8.56×10(-6))...
  48. Pan X, Lou Y, Zhang Z, Xu G, Jia P, Tong J. [Regulation mechanism for rig-g gene expression induced by all-trans retinoic acid]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:31-5 pubmed
    ..The complex of IRF-9 and STAT2 is the primary transcriptional factor for rig-g gene induction. This study will be helpful for better understanding the signal transduction networks of ATRA during the course of APL cell differentiation. ..
  49. Lou Y, Pan X, Jia P, Li D, Zhang Z, Xu G, et al. [A novel molecular mechanism of interferon alpha-regulated expression of retinoic acid-induced gene G]. Zhonghua Zhong Liu Za Zhi. 2010;32:88-92 pubmed
    ..The complex STAT2/IRF-9 is the key factor mediating the expression of RIG-G gene regulated by IFN-alpha. This is a novel signal transduction cascade for IFN which is different from the classical JAK-STAT pathway. ..
  50. Xu G, Zhang Z, Xiao S, Zhuang L, Xia D, Zou Q, et al. Rig-G negatively regulates SCF-E3 ligase activities by disrupting the assembly of COP9 signalosome complex. Biochem Biophys Res Commun. 2013;432:425-30 pubmed publisher
  51. Li D, Sun J, Liu W, Wang X, Bals R, Wu J, et al. Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB. Oncotarget. 2016;7:66032-66050 pubmed publisher
    ..Our findings contribute to a better understanding of the antitumor effect mechanism of Rig-G, as well as offer a novel strategy for lung cancer therapy. ..
  52. Jiang Z, Su C, Zheng C. Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity. J Virol. 2016;90:11056-11061 pubmed
    The interferon-induced protein with tetratricopeptide repeat 3 (IFIT3 or ISG60) is a host-intrinsic antiviral factor that restricts many instances of DNA and RNA virus replication...
  53. Shi D, Bai Q, Zhou S, Liu X, Liu H, Yao X. Molecular dynamics simulation, binding free energy calculation and unbinding pathway analysis on selectivity difference between FKBP51 and FKBP52: insight into the molecular mechanism of isoform selectivity. Proteins. 2017;: pubmed publisher
    ..binding free energy calculation and unbinding pathway analysis to reveal selective mechanism for the inhibitor iFit4 binding with FKBP51 and FKBP52...
  54. Ikeda K, Hayakawa K, Fujishiro M, Kawasaki M, Hirai T, Tsushima H, et al. JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation. BMC Immunol. 2017;18:41 pubmed publisher
    ..We also detected decreased expression of several IFN-signature genes Ifit3 and Isg15 in CD4+ from SLE-prone mice following TOFA and DEXA treatment, and IFIT3 in CD3+ T ..
  55. Imaizumi T, Yoshida H, Hayakari R, Xing F, Wang L, Matsumiya T, et al. Interferon-stimulated gene (ISG) 60, as well as ISG56 and ISG54, positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells. Neurosci Res. 2016;105:35-41 pubmed publisher
    ..In the present study, we demonstrated that poly IC induces the expression of ISG60, also named as IFIT3, in U373MG cells...
  56. Zahoor M, Xue G, Sato H, Murakami T, Takeshima S, Aida Y. HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages. PLoS ONE. 2014;9:e106418 pubmed publisher
    ..and genes involved in the innate immune response, including STAT1, IRF7, MX1, MX2, ISG15, ISG20, IFIT1, IFIT2, IFIT3, IFI27, IFI44L, APOBEC3A, DDX58 (RIG-I), TNFSF10 (TRAIL), and RSAD2 (viperin) were confirmed by real-time ..
  57. Popp F, Popp M, Zhao Y, Betzler C, Kropf S, Garlipp B, et al. Protocol of the PANCALYZE trial: a multicenter, prospective study investigating the tumor biomarkers CXCR4, SMAD4, SOX9 and IFIT3 in patients with resected pancreatic adenocarcinoma to predict the pattern of recurrence of the disease. BMC Cancer. 2017;17:229 pubmed publisher
    ..Biomarker expression of CXCR4, SMAD4, SOX9 and IFIT3 will be prospectively assessed by immunohistochemistry and verified by rt...
  58. Kurihara M, Otsuka K, Matsubara S, Shiraishi A, Satake H, Kimura A. A Testis-Specific Long Non-Coding RNA, lncRNA-Tcam1, Regulates Immune-Related Genes in Mouse Male Germ Cells. Front Endocrinol (Lausanne). 2017;8:299 pubmed publisher
    ..Induction of lncRNA-Tcam1 transcription using the Tet-off system verified that six genes, Trim30a, Ifit3, Tgtp2, Ifi47, Oas1g, and Gbp3, were upregulated in GC-2spd(ts) cells, indicating that lncRNA-Tcam1
  59. Zhu X, He Z, Yuan J, Wen W, Huang X, Hu Y, et al. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cell Microbiol. 2015;17:105-18 pubmed publisher
    ..Conceivably, variations in the basal and inducible levels of IFITMs, as well as in intracellular and extracellular levels of IFITMs, might predict the severity of dengue virus infections among individuals or across species. ..
  60. Ellegård R, Crisci E, Burgener A, Sjöwall C, Birse K, Westmacott G, et al. Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3. J Immunol. 2014;193:4590-601 pubmed publisher
    ..The impact that viral hijacking of the complement system has on iDC function could be an important immune evasion mechanism used by HIV-1 to establish infection in the host. ..
  61. Burchill M, Roby J, Crochet N, Wind Rotolo M, STONE A, Edwards M, et al. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy. PLoS ONE. 2017;12:e0186213 pubmed publisher
    ..Specifically, we see a rapid decline in the expression of genes associated with chronic IFN stimulation (IFIT3, USP18, IFIT1) as well as a rapid decline in genes associated with inflammation (IL1?, CXCL10, CXCL11) in the ..
  62. Ezzati P, Komher K, Severini G, Coombs K. Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells. Front Cell Infect Microbiol. 2015;5:30 pubmed publisher
    ..This study expands our understanding of reovirus-induced host responses. ..
  63. Price A, Tedesco D, Prasad M, Workowski K, Walker C, Suthar M, et al. Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype. Proc Natl Acad Sci U S A. 2016;113:10678-83 pubmed publisher
    ..Interestingly, interferon-stimulated genes (ISGs) encoding proteins such as IFIT1, IFIT2, and IFIT3, as well as signaling proteins such as STAT1, STAT2, and MAVS, were enriched postpartum...
  64. Lou Y, Pan X, Xu G, Zhuang L, Jia P, Tong J. [Role of auto-secreted interferon ? in all-trans retinoic acid-induced expression of RIG-G gene]. Zhonghua Yi Xue Za Zhi. 2012;92:124-7 pubmed
    ..ATRA increases the secretion of IFN-? by up-regulating the protein level of IRF-1. Then the secreted IFN-? may induce the phosphorylation of STAT2 and reinforce the expression of RIG-G. ..
  65. Honegger J, Tedesco D, Kohout J, Prasad M, Price A, Lindquist T, et al. Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery. Proc Natl Acad Sci U S A. 2016;113:10684-9 pubmed publisher
    ..Together, these findings support a model where spontaneous control of HCV such as sometimes follows pregnancy is governed by genetic polymorphisms that affect type III IFN signaling and virus-specific cellular immune responses. ..
  66. Huang X, Shen N, Bao C, Gu Y, Wu L, Chen S. Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells. Arthritis Res Ther. 2008;10:R91 pubmed publisher
    ..Among these IFN-inducible genes, IFN-induced protein with tetratricopeptide repeats 4 (IFIT4) is a novel gene whose function is unknown...